From bfe8909bd84a4b39bf08179359da3c777391f0a4 Mon Sep 17 00:00:00 2001 From: luponzo86 Date: Thu, 29 Aug 2019 10:55:21 -0700 Subject: [PATCH 01/24] docs for rhapsody.__init__ --- docs/README | 26 ++++++++++++++++++++++++++ docs/conf.py | 14 +++++++++++++- rhapsody/predict/core.py | 27 +++++++++++++++++++++++++++ 3 files changed, 66 insertions(+), 1 deletion(-) create mode 100644 docs/README diff --git a/docs/README b/docs/README new file mode 100644 index 0000000..a86b0ac --- /dev/null +++ b/docs/README @@ -0,0 +1,26 @@ +Example of documentation string: + +function(arg, kwarg=None): +""" General description. Please use this syntax rules: + +- :class:`~numpy.ndarray` +- :meth:`setSomething` or :meth:`.setSomething` +- :func:`someFunction` or :func:`.someFunction` +- **None** +You can insert refs too ([ref]_). + +:arg arg: detailed description. + This is how you make a bullet list in an argument's description: + + - if *arg* = **None** (default), blah blah + - if *arg* = ``'something else'``, blah blah +:type arg: str, list, bool, whatever +:arg kwarg: blah blah +:type kwarg: str +:return: something +:rtype: str + +.. [ref] Ponzoni L, Bahar I. Structural dynamics is a determinant of + the functional significance of missense variants. *PNAS* **2018** + 115 (16) 4164-4169. +""" \ No newline at end of file diff --git a/docs/conf.py b/docs/conf.py index cf02736..96626b0 100644 --- a/docs/conf.py +++ b/docs/conf.py @@ -42,7 +42,8 @@ # List of patterns, relative to source directory, that match files and # directories to ignore when looking for source files. # This pattern also affects html_static_path and html_extra_path. -exclude_patterns = ['_build', '_backup', 'Thumbs.db', '.DS_Store', '**tar.gz**'] +exclude_patterns = ['_build', '_backup', 'Thumbs.db', '.DS_Store', + '**tar.gz**'] # The name of the Pygments (syntax highlighting) style to use. pygments_style = 'sphinx' @@ -60,6 +61,17 @@ # autosummary_generate = True +# functions for including __init__ documentation +def skip(app, what, name, obj, would_skip, options): + if name == "__init__": + return False + return would_skip + + +def setup(app): + app.connect("autodoc-skip-member", skip) + + # -- Options for HTML output ------------------------------------------------- # The theme to use for HTML and HTML Help pages. See the documentation for diff --git a/rhapsody/predict/core.py b/rhapsody/predict/core.py index 7d22609..6cabd95 100644 --- a/rhapsody/predict/core.py +++ b/rhapsody/predict/core.py @@ -23,6 +23,33 @@ class Rhapsody: """ def __init__(self, query=None, query_type='SAVs', queryPolyPhen2=True): + """ Initialize a Rhapsody object with a list of SAVs (optional). + + :arg query: Single Amino Acid Variants (SAVs) in Uniprot coordinates. + + - If **None**, the SAV list can be imported at a later moment, by + using ``.importPolyPhen2output()``, ``.queryPolyPhen2()`` or + ``.setSAVs()`` + + - if *query_type* = ``'SAVs'`` (default), *query* should be a + filename, a string or a list/tuple of strings, containing Uniprot + SAV coordinates, with the format ``'P17516 135 G E'``. The string + could also be just a single Uniprot sequence identifier (e.g. + ``'P17516'``), or the coordinate of a specific site in a sequence + (e.g. ``'P17516 135'``), in which case all possible 19 amino acid + substitutions at the specified positions will be analyzed. + - if *query_type* = ``'PolyPhen2'``, *query* should be a filename + containing the output from PolyPhen-2, usually named + :file:`pph2-full.txt` + :type query: str, list + + :arg query_type: ``'SAVs'`` or ``'PolyPhen2'`` + :type query_type: str + + :arg queryPolyPhen2: if ``True``, the PolyPhen-2 online tool will be + queryied with the list of SAVs + :type queryPolyPhen2: bool + """ assert query_type in ('SAVs', 'PolyPhen2') assert isinstance(queryPolyPhen2, bool) From efebacab474ea8e130c4869a7eb54bea056587c9 Mon Sep 17 00:00:00 2001 From: luponzo86 Date: Thu, 29 Aug 2019 17:15:10 -0700 Subject: [PATCH 02/24] upload sequence to PolyPhen2 if discrepancy is found in selected isoform. Test-2 added as well --- rhapsody/features/PolyPhen2.py | 68 +- rhapsody/predict/core.py | 11 +- rhapsody/predict/figures.py | 1 + test/{test-1 => }/.gitignore | 0 test/test-2/data/RAS_customPDB.pdb | 2125 ++++++++++++++ test/test-2/data/UniprotMap-P01112.pkl | Bin 0 -> 1018673 bytes test/test-2/data/pph2-full.txt | 3598 ++++++++++++++++++++++++ test/test-2/test-2.py | 37 + 8 files changed, 5829 insertions(+), 11 deletions(-) rename test/{test-1 => }/.gitignore (100%) create mode 100644 test/test-2/data/RAS_customPDB.pdb create mode 100644 test/test-2/data/UniprotMap-P01112.pkl create mode 100644 test/test-2/data/pph2-full.txt create mode 100644 test/test-2/test-2.py diff --git a/rhapsody/features/PolyPhen2.py b/rhapsody/features/PolyPhen2.py index ed43900..7897059 100644 --- a/rhapsody/features/PolyPhen2.py +++ b/rhapsody/features/PolyPhen2.py @@ -4,7 +4,7 @@ classifiers. """ -from prody import LOGGER +from prody import LOGGER, queryUniprot import numpy as np import requests from requests.adapters import HTTPAdapter @@ -44,7 +44,36 @@ def _requests_retry_session(retries=10, timeout=1, backoff_factor=0.3, return session -def queryPolyPhen2(filename, dump=True, prefix='pph2', **kwargs): +def _check_log_errors(text): + error_strings = [ + 'ERROR: Neither AA1', + 'ERROR: Invalid variation position', + 'WARNING: Swapped input residues AA1' + ] + accs = [] + for line in text.split('\n'): + if any([s in line for s in error_strings]): + acc = line.split(':')[0][1:] + accs.append(acc) + Uniprot_accs = set(accs) + if Uniprot_accs: + LOGGER.warn('Wrong SAV coordinates detected for ' + f'the following Uniprot sequences: {Uniprot_accs}') + return Uniprot_accs + + +def _print_fasta_file(Uniprot_accs, filename='custom_sequences.fasta'): + with open(filename, 'w', 1) as f: + for acc in Uniprot_accs: + f.write(f">{acc}") + record = queryUniprot(acc) + sequence = record['sequence 0'] + f.write(sequence) + return filename + + +def queryPolyPhen2(filename, dump=True, prefix='pph2', + fasta_file=None, fix_isoforms=False, **kwargs): # original PolyPhen-2 curl command (see: # http://genetics.bwh.harvard.edu/pph2/dokuwiki/faq ): # @@ -62,13 +91,19 @@ def queryPolyPhen2(filename, dump=True, prefix='pph2', **kwargs): input_file = open(filename, 'rb') # submit query address = 'http://genetics.bwh.harvard.edu/cgi-bin/ggi/ggi2.cgi' - files = {'_ggi_project': (None, 'PPHWeb2'), - '_ggi_origin': (None, 'query'), - '_ggi_target_pipeline': (None, '1'), - '_ggi_batch_file': ('query.txt', input_file), - 'MODELNAME': (None, kwargs.get('MODELNAME', 'HumDiv')), - 'UCSCDB': (None, kwargs.get('UCSCDB', 'hg19')), - 'SNPFUNC': (None, kwargs.get('SNPFUNC', 'm'))} + files = { + '_ggi_project': (None, 'PPHWeb2'), + '_ggi_origin': (None, 'query'), + '_ggi_target_pipeline': (None, '1'), + '_ggi_batch_file': ('query.txt', input_file), + 'MODELNAME': (None, kwargs.get('MODELNAME', 'HumDiv')), + 'UCSCDB': (None, kwargs.get('UCSCDB', 'hg19')), + 'SNPFUNC': (None, kwargs.get('SNPFUNC', 'm')) + } + if fasta_file is not None: + # upload custom sequences + custom_fasta = open(fasta_file, 'rb') + files['uploaded_sequences_1'] = ('sequences.fa', custom_fasta) response = requests.post(address, files=files) # parse job ID from response page jobID = response.cookies['polyphenweb2'] @@ -106,6 +141,21 @@ def queryPolyPhen2(filename, dump=True, prefix='pph2', **kwargs): with open(prefix + '-' + k + '.txt', 'w', 1) as f: print(r.text, file=f) + # check for conflicts between Uniprot sequences and isoforms used + # by Polyhen-2 (which could be outdated) + Uniprot_accs = _check_log_errors(output['log'].text) + if Uniprot_accs: + if fix_isoforms: + LOGGER.info('PolyPhen-2 may have picked the wrong isoforms. ' + 'Resubmitting query with correct isoforms...') + # resubmit query by manually uploading fasta sequences + fasta_fname = _print_fasta_file(Uniprot_accs) + output = queryPolyPhen2( + filename, dump=dump, prefix=prefix, + fasta_file=fasta_fname, fix_isoforms=False, **kwargs) + else: + LOGGER.error('Please check PolyPhen-2 log file') + return output diff --git a/rhapsody/predict/core.py b/rhapsody/predict/core.py index 6cabd95..dc9b73e 100644 --- a/rhapsody/predict/core.py +++ b/rhapsody/predict/core.py @@ -143,6 +143,8 @@ def _isSaturationMutagenesis(self): generated_SAV_list = Uniprot.seqScanning(query) if SAV_list == generated_SAV_list: self.saturation_mutagenesis = True + else: + raise RuntimeError('Missing SAVs detected.') except Exception as e: LOGGER.warn(f'Not a saturation mutagenesis list: {e}') return self.saturation_mutagenesis @@ -188,6 +190,7 @@ def queryPolyPhen2(self, query, filename='rhapsody-SAVs.txt'): assert self.data is None, 'SAV list already set.' assert self.PolyPhen2output is None, "PolyPhen-2 output " \ "already imported." + fix_isoforms = False if isinstance(query, str) and isfile(query): # 'query' is a filename SAV_file = query @@ -195,12 +198,16 @@ def queryPolyPhen2(self, query, filename='rhapsody-SAVs.txt'): # single Uniprot acc (+ pos), e.g. 'P17516' or 'P17516 135' SAV_list = Uniprot.seqScanning(query) SAV_file = Uniprot.printSAVlist(SAV_list, filename) + # only when submitting a saturation mutagenesis list, try and + # fix possible wrong isoforms used by PolyPhen-2 + fix_isoforms = True else: # 'query' is a list, tuple or single string of SAV coordinates SAV_file = Uniprot.printSAVlist(query, filename) # submit query to PolyPhen-2 try: - PolyPhen2_output = PolyPhen2.queryPolyPhen2(SAV_file) + PolyPhen2_output = PolyPhen2.queryPolyPhen2( + SAV_file, fix_isoforms=fix_isoforms) except Exception as e: err = (f'Unable to get a response from PolyPhen-2: {e} \n' 'Please click "Check Status" on the server homepage \n' @@ -805,7 +812,7 @@ def writePDBs(self, PDBID=None, predictions='best', path_prob=True, assert predictions in ['best', 'main', 'aux', 'PolyPhen-2', 'EVmutation'] if not self._isSaturationMutagenesis(): - LOGGER.warn('This function is available only when performing ', + LOGGER.warn('This function is available only when performing ' 'saturation mutagenesis analysis') return None # select prediction set to be printed on PDB file diff --git a/rhapsody/predict/figures.py b/rhapsody/predict/figures.py index b9ab2e9..fb33093 100644 --- a/rhapsody/predict/figures.py +++ b/rhapsody/predict/figures.py @@ -46,6 +46,7 @@ def print_sat_mutagen_figure(filename, rhapsody_obj, res_interval=None, assert isinstance(filename, str), 'filename must be a string' assert isinstance(rhapsody_obj, Rhapsody), 'not a Rhapsody object' assert rhapsody_obj._isColSet('main score'), 'predictions not found' + assert rhapsody_obj._isSaturationMutagenesis(), 'unable to create figure' if res_interval is not None: assert isinstance(res_interval, tuple) and len(res_interval) == 2, \ 'res_interval must be a tuple of 2 values' diff --git a/test/test-1/.gitignore b/test/.gitignore similarity index 100% rename from test/test-1/.gitignore rename to test/.gitignore diff --git a/test/test-2/data/RAS_customPDB.pdb b/test/test-2/data/RAS_customPDB.pdb new file mode 100644 index 0000000..fea7cb9 --- /dev/null +++ b/test/test-2/data/RAS_customPDB.pdb @@ -0,0 +1,2125 @@ +HEADER SIGNALING PROTEIN 14-DEC-11 3V4F +TITLE H-RAS PEG 400/CACL2, ORDERED OFF +COMPND MOL_ID: 1; +COMPND 2 MOLECULE: GTPASE HRAS; +COMPND 3 CHAIN: A; +COMPND 4 SYNONYM: H-RAS-1, TRANSFORMING PROTEIN P21, C-H-RAS, P21RAS, GTPASE +COMPND 5 HRAS, N-TERMINALLY PROCESSED; +COMPND 6 ENGINEERED: YES +SOURCE MOL_ID: 1; +SOURCE 2 ORGANISM_SCIENTIFIC: RATTUS NORVEGICUS; +SOURCE 3 ORGANISM_COMMON: RAT; +SOURCE 4 ORGANISM_TAXID: 10116; +SOURCE 5 GENE: HRAS, HRAS1; +SOURCE 6 EXPRESSION_SYSTEM: ESCHERICHIA COLI; +SOURCE 7 EXPRESSION_SYSTEM_TAXID: 562; +SOURCE 8 EXPRESSION_SYSTEM_STRAIN: BL21(DE3); +SOURCE 9 EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID; +SOURCE 10 EXPRESSION_SYSTEM_PLASMID: PET21 +KEYWDS GTP-BINDING, NUCLEOTIDE BINDING, SIGNALING PROTEIN +EXPDTA X-RAY DIFFRACTION +AUTHOR G.HOLZAPFEL,C.MATTOS +REVDAT 4 08-NOV-17 3V4F 1 REMARK +REVDAT 3 17-OCT-12 3V4F 1 JRNL +REVDAT 2 15-AUG-12 3V4F 1 TITLE +REVDAT 1 08-AUG-12 3V4F 0 +JRNL AUTH G.HOLZAPFEL,G.BUHRMAN,C.MATTOS +JRNL TITL SHIFT IN THE EQUILIBRIUM BETWEEN ON AND OFF STATES OF THE +JRNL TITL 2 ALLOSTERIC SWITCH IN RAS-GPPNHP AFFECTED BY SMALL MOLECULES +JRNL TITL 3 AND BULK SOLVENT COMPOSITION. +JRNL REF BIOCHEMISTRY V. 51 6114 2012 +JRNL REFN ISSN 0006-2960 +JRNL PMID 22845804 +JRNL DOI 10.1021/BI300509J +REMARK 2 +REMARK 2 RESOLUTION. 1.39 ANGSTROMS. +REMARK 3 +REMARK 3 REFINEMENT. +REMARK 3 PROGRAM : PHENIX 1.7.1_743 +REMARK 3 AUTHORS : PAUL ADAMS,PAVEL AFONINE,VINCENT CHEN,IAN +REMARK 3 : DAVIS,KRESHNA GOPAL,RALF GROSSE-KUNSTLEVE, +REMARK 3 : LI-WEI HUNG,ROBERT IMMORMINO,TOM IOERGER, +REMARK 3 : AIRLIE MCCOY,ERIK MCKEE,NIGEL MORIARTY, +REMARK 3 : REETAL PAI,RANDY READ,JANE RICHARDSON, +REMARK 3 : DAVID RICHARDSON,TOD ROMO,JIM SACCHETTINI, +REMARK 3 : NICHOLAS SAUTER,JACOB SMITH,LAURENT +REMARK 3 : STORONI,TOM TERWILLIGER,PETER ZWART +REMARK 3 +REMARK 3 REFINEMENT TARGET : ML +REMARK 3 +REMARK 3 DATA USED IN REFINEMENT. +REMARK 3 RESOLUTION RANGE HIGH (ANGSTROMS) : 1.39 +REMARK 3 RESOLUTION RANGE LOW (ANGSTROMS) : 33.27 +REMARK 3 MIN(FOBS/SIGMA_FOBS) : 1.340 +REMARK 3 COMPLETENESS FOR RANGE (%) : 99.7 +REMARK 3 NUMBER OF REFLECTIONS : 40649 +REMARK 3 +REMARK 3 FIT TO DATA USED IN REFINEMENT. +REMARK 3 R VALUE (WORKING + TEST SET) : 0.184 +REMARK 3 R VALUE (WORKING SET) : 0.183 +REMARK 3 FREE R VALUE : 0.198 +REMARK 3 FREE R VALUE TEST SET SIZE (%) : 4.920 +REMARK 3 FREE R VALUE TEST SET COUNT : 1999 +REMARK 3 +REMARK 3 FIT TO DATA USED IN REFINEMENT (IN BINS). +REMARK 3 BIN RESOLUTION RANGE COMPL. NWORK NFREE RWORK RFREE +REMARK 3 1 33.2839 - 3.3506 1.00 2902 150 0.1743 0.1895 +REMARK 3 2 3.3506 - 2.6598 1.00 2807 145 0.1769 0.1904 +REMARK 3 3 2.6598 - 2.3237 1.00 2781 144 0.1812 0.1847 +REMARK 3 4 2.3237 - 2.1113 1.00 2769 144 0.1746 0.1839 +REMARK 3 5 2.1113 - 1.9600 1.00 2774 143 0.1732 0.2070 +REMARK 3 6 1.9600 - 1.8444 1.00 2752 142 0.1590 0.1922 +REMARK 3 7 1.8444 - 1.7521 1.00 2777 143 0.1649 0.1867 +REMARK 3 8 1.7521 - 1.6758 1.00 2742 142 0.1735 0.2008 +REMARK 3 9 1.6758 - 1.6113 1.00 2741 142 0.1799 0.1849 +REMARK 3 10 1.6113 - 1.5557 1.00 2749 142 0.1863 0.1870 +REMARK 3 11 1.5557 - 1.5070 1.00 2741 141 0.2084 0.2141 +REMARK 3 12 1.5070 - 1.4640 1.00 2755 142 0.2576 0.2935 +REMARK 3 13 1.4640 - 1.4254 1.00 2726 142 0.3121 0.3256 +REMARK 3 14 1.4254 - 1.3906 0.96 2634 137 0.3826 0.3437 +REMARK 3 +REMARK 3 BULK SOLVENT MODELLING. +REMARK 3 METHOD USED : FLAT BULK SOLVENT MODEL +REMARK 3 SOLVENT RADIUS : 1.11 +REMARK 3 SHRINKAGE RADIUS : 0.90 +REMARK 3 K_SOL : 0.42 +REMARK 3 B_SOL : 55.86 +REMARK 3 +REMARK 3 ERROR ESTIMATES. +REMARK 3 COORDINATE ERROR (MAXIMUM-LIKELIHOOD BASED) : 0.370 +REMARK 3 PHASE ERROR (DEGREES, MAXIMUM-LIKELIHOOD BASED) : 18.260 +REMARK 3 +REMARK 3 B VALUES. +REMARK 3 FROM WILSON PLOT (A**2) : NULL +REMARK 3 MEAN B VALUE (OVERALL, A**2) : 20.84 +REMARK 3 OVERALL ANISOTROPIC B VALUE. +REMARK 3 B11 (A**2) : -1.09460 +REMARK 3 B22 (A**2) : -1.09460 +REMARK 3 B33 (A**2) : 2.18920 +REMARK 3 B12 (A**2) : 0.00000 +REMARK 3 B13 (A**2) : 0.00000 +REMARK 3 B23 (A**2) : 0.00000 +REMARK 3 +REMARK 3 TWINNING INFORMATION. +REMARK 3 FRACTION: NULL +REMARK 3 OPERATOR: NULL +REMARK 3 +REMARK 3 DEVIATIONS FROM IDEAL VALUES. +REMARK 3 RMSD COUNT +REMARK 3 BOND : 0.007 1397 +REMARK 3 ANGLE : 1.169 1901 +REMARK 3 CHIRALITY : 0.068 214 +REMARK 3 PLANARITY : 0.005 244 +REMARK 3 DIHEDRAL : 14.370 530 +REMARK 3 +REMARK 3 TLS DETAILS +REMARK 3 NUMBER OF TLS GROUPS : NULL +REMARK 3 +REMARK 3 NCS DETAILS +REMARK 3 NUMBER OF NCS GROUPS : NULL +REMARK 3 +REMARK 3 OTHER REFINEMENT REMARKS: NULL +REMARK 4 +REMARK 4 3V4F COMPLIES WITH FORMAT V. 3.30, 13-JUL-11 +REMARK 100 +REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY RCSB ON 16-DEC-11. +REMARK 100 THE DEPOSITION ID IS D_1000069581. +REMARK 200 +REMARK 200 EXPERIMENTAL DETAILS +REMARK 200 EXPERIMENT TYPE : X-RAY DIFFRACTION +REMARK 200 DATE OF DATA COLLECTION : 05-DEC-11 +REMARK 200 TEMPERATURE (KELVIN) : 100 +REMARK 200 PH : 7.5 +REMARK 200 NUMBER OF CRYSTALS USED : 1 +REMARK 200 +REMARK 200 SYNCHROTRON (Y/N) : Y +REMARK 200 RADIATION SOURCE : APS +REMARK 200 BEAMLINE : NULL +REMARK 200 X-RAY GENERATOR MODEL : NULL +REMARK 200 MONOCHROMATIC OR LAUE (M/L) : M +REMARK 200 WAVELENGTH OR RANGE (A) : 1.0 +REMARK 200 MONOCHROMATOR : CRYSTAL +REMARK 200 OPTICS : NULL +REMARK 200 +REMARK 200 DETECTOR TYPE : CCD +REMARK 200 DETECTOR MANUFACTURER : MARRESEARCH +REMARK 200 INTENSITY-INTEGRATION SOFTWARE : DENZO +REMARK 200 DATA SCALING SOFTWARE : SCALEPACK +REMARK 200 +REMARK 200 NUMBER OF UNIQUE REFLECTIONS : 40675 +REMARK 200 RESOLUTION RANGE HIGH (A) : 1.390 +REMARK 200 RESOLUTION RANGE LOW (A) : 35.000 +REMARK 200 REJECTION CRITERIA (SIGMA(I)) : NULL +REMARK 200 +REMARK 200 OVERALL. +REMARK 200 COMPLETENESS FOR RANGE (%) : 99.9 +REMARK 200 DATA REDUNDANCY : 10.10 +REMARK 200 R MERGE (I) : 0.06300 +REMARK 200 R SYM (I) : NULL +REMARK 200 FOR THE DATA SET : 14.1000 +REMARK 200 +REMARK 200 IN THE HIGHEST RESOLUTION SHELL. +REMARK 200 HIGHEST RESOLUTION SHELL, RANGE HIGH (A) : 1.39 +REMARK 200 HIGHEST RESOLUTION SHELL, RANGE LOW (A) : 1.41 +REMARK 200 COMPLETENESS FOR SHELL (%) : 98.4 +REMARK 200 DATA REDUNDANCY IN SHELL : 5.00 +REMARK 200 R MERGE FOR SHELL (I) : 0.79600 +REMARK 200 R SYM FOR SHELL (I) : NULL +REMARK 200 FOR SHELL : NULL +REMARK 200 +REMARK 200 DIFFRACTION PROTOCOL: SINGLE WAVELENGTH +REMARK 200 METHOD USED TO DETERMINE THE STRUCTURE: MOLECULAR REPLACEMENT +REMARK 200 SOFTWARE USED: PHASER +REMARK 200 STARTING MODEL: NULL +REMARK 200 +REMARK 200 REMARK: NULL +REMARK 280 +REMARK 280 CRYSTAL +REMARK 280 SOLVENT CONTENT, VS (%): 54.06 +REMARK 280 MATTHEWS COEFFICIENT, VM (ANGSTROMS**3/DA): 2.68 +REMARK 280 +REMARK 280 CRYSTALLIZATION CONDITIONS: 20% PEG 3350 200 MM CACL2, PH 7.5, +REMARK 280 VAPOR DIFFUSION, HANGING DROP, TEMPERATURE 298K +REMARK 290 +REMARK 290 CRYSTALLOGRAPHIC SYMMETRY +REMARK 290 SYMMETRY OPERATORS FOR SPACE GROUP: H 3 2 +REMARK 290 +REMARK 290 SYMOP SYMMETRY +REMARK 290 NNNMMM OPERATOR +REMARK 290 1555 X,Y,Z +REMARK 290 2555 -Y,X-Y,Z +REMARK 290 3555 -X+Y,-X,Z +REMARK 290 4555 Y,X,-Z +REMARK 290 5555 X-Y,-Y,-Z +REMARK 290 6555 -X,-X+Y,-Z +REMARK 290 7555 X+2/3,Y+1/3,Z+1/3 +REMARK 290 8555 -Y+2/3,X-Y+1/3,Z+1/3 +REMARK 290 9555 -X+Y+2/3,-X+1/3,Z+1/3 +REMARK 290 10555 Y+2/3,X+1/3,-Z+1/3 +REMARK 290 11555 X-Y+2/3,-Y+1/3,-Z+1/3 +REMARK 290 12555 -X+2/3,-X+Y+1/3,-Z+1/3 +REMARK 290 13555 X+1/3,Y+2/3,Z+2/3 +REMARK 290 14555 -Y+1/3,X-Y+2/3,Z+2/3 +REMARK 290 15555 -X+Y+1/3,-X+2/3,Z+2/3 +REMARK 290 16555 Y+1/3,X+2/3,-Z+2/3 +REMARK 290 17555 X-Y+1/3,-Y+2/3,-Z+2/3 +REMARK 290 18555 -X+1/3,-X+Y+2/3,-Z+2/3 +REMARK 290 +REMARK 290 WHERE NNN -> OPERATOR NUMBER +REMARK 290 MMM -> TRANSLATION VECTOR +REMARK 290 +REMARK 290 CRYSTALLOGRAPHIC SYMMETRY TRANSFORMATIONS +REMARK 290 THE FOLLOWING TRANSFORMATIONS OPERATE ON THE ATOM/HETATM +REMARK 290 RECORDS IN THIS ENTRY TO PRODUCE CRYSTALLOGRAPHICALLY +REMARK 290 RELATED MOLECULES. +REMARK 290 SMTRY1 1 1.000000 0.000000 0.000000 0.00000 +REMARK 290 SMTRY2 1 0.000000 1.000000 0.000000 0.00000 +REMARK 290 SMTRY3 1 0.000000 0.000000 1.000000 0.00000 +REMARK 290 SMTRY1 2 -0.500000 -0.866025 0.000000 0.00000 +REMARK 290 SMTRY2 2 0.866025 -0.500000 0.000000 0.00000 +REMARK 290 SMTRY3 2 0.000000 0.000000 1.000000 0.00000 +REMARK 290 SMTRY1 3 -0.500000 0.866025 0.000000 0.00000 +REMARK 290 SMTRY2 3 -0.866025 -0.500000 0.000000 0.00000 +REMARK 290 SMTRY3 3 0.000000 0.000000 1.000000 0.00000 +REMARK 290 SMTRY1 4 -0.500000 0.866025 0.000000 0.00000 +REMARK 290 SMTRY2 4 0.866025 0.500000 0.000000 0.00000 +REMARK 290 SMTRY3 4 0.000000 0.000000 -1.000000 0.00000 +REMARK 290 SMTRY1 5 1.000000 0.000000 0.000000 0.00000 +REMARK 290 SMTRY2 5 0.000000 -1.000000 0.000000 0.00000 +REMARK 290 SMTRY3 5 0.000000 0.000000 -1.000000 0.00000 +REMARK 290 SMTRY1 6 -0.500000 -0.866025 0.000000 0.00000 +REMARK 290 SMTRY2 6 -0.866025 0.500000 0.000000 0.00000 +REMARK 290 SMTRY3 6 0.000000 0.000000 -1.000000 0.00000 +REMARK 290 SMTRY1 7 1.000000 0.000000 0.000000 44.26050 +REMARK 290 SMTRY2 7 0.000000 1.000000 0.000000 25.55381 +REMARK 290 SMTRY3 7 0.000000 0.000000 1.000000 44.68667 +REMARK 290 SMTRY1 8 -0.500000 -0.866025 0.000000 44.26050 +REMARK 290 SMTRY2 8 0.866025 -0.500000 0.000000 25.55381 +REMARK 290 SMTRY3 8 0.000000 0.000000 1.000000 44.68667 +REMARK 290 SMTRY1 9 -0.500000 0.866025 0.000000 44.26050 +REMARK 290 SMTRY2 9 -0.866025 -0.500000 0.000000 25.55381 +REMARK 290 SMTRY3 9 0.000000 0.000000 1.000000 44.68667 +REMARK 290 SMTRY1 10 -0.500000 0.866025 0.000000 44.26050 +REMARK 290 SMTRY2 10 0.866025 0.500000 0.000000 25.55381 +REMARK 290 SMTRY3 10 0.000000 0.000000 -1.000000 44.68667 +REMARK 290 SMTRY1 11 1.000000 0.000000 0.000000 44.26050 +REMARK 290 SMTRY2 11 0.000000 -1.000000 0.000000 25.55381 +REMARK 290 SMTRY3 11 0.000000 0.000000 -1.000000 44.68667 +REMARK 290 SMTRY1 12 -0.500000 -0.866025 0.000000 44.26050 +REMARK 290 SMTRY2 12 -0.866025 0.500000 0.000000 25.55381 +REMARK 290 SMTRY3 12 0.000000 0.000000 -1.000000 44.68667 +REMARK 290 SMTRY1 13 1.000000 0.000000 0.000000 0.00000 +REMARK 290 SMTRY2 13 0.000000 1.000000 0.000000 51.10762 +REMARK 290 SMTRY3 13 0.000000 0.000000 1.000000 89.37333 +REMARK 290 SMTRY1 14 -0.500000 -0.866025 0.000000 0.00000 +REMARK 290 SMTRY2 14 0.866025 -0.500000 0.000000 51.10762 +REMARK 290 SMTRY3 14 0.000000 0.000000 1.000000 89.37333 +REMARK 290 SMTRY1 15 -0.500000 0.866025 0.000000 0.00000 +REMARK 290 SMTRY2 15 -0.866025 -0.500000 0.000000 51.10762 +REMARK 290 SMTRY3 15 0.000000 0.000000 1.000000 89.37333 +REMARK 290 SMTRY1 16 -0.500000 0.866025 0.000000 0.00000 +REMARK 290 SMTRY2 16 0.866025 0.500000 0.000000 51.10762 +REMARK 290 SMTRY3 16 0.000000 0.000000 -1.000000 89.37333 +REMARK 290 SMTRY1 17 1.000000 0.000000 0.000000 0.00000 +REMARK 290 SMTRY2 17 0.000000 -1.000000 0.000000 51.10762 +REMARK 290 SMTRY3 17 0.000000 0.000000 -1.000000 89.37333 +REMARK 290 SMTRY1 18 -0.500000 -0.866025 0.000000 0.00000 +REMARK 290 SMTRY2 18 -0.866025 0.500000 0.000000 51.10762 +REMARK 290 SMTRY3 18 0.000000 0.000000 -1.000000 89.37333 +REMARK 290 +REMARK 290 REMARK: NULL +REMARK 300 +REMARK 300 BIOMOLECULE: 1 +REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM +REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN +REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON +REMARK 300 BURIED SURFACE AREA. +REMARK 350 +REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN +REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE +REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS +REMARK 350 GIVEN BELOW. BOTH NON-CRYSTALLOGRAPHIC AND +REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN. +REMARK 350 +REMARK 350 BIOMOLECULE: 1 +REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: HEXAMERIC +REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: HEXAMERIC +REMARK 350 SOFTWARE USED: PISA +REMARK 350 TOTAL BURIED SURFACE AREA: 13800 ANGSTROM**2 +REMARK 350 SURFACE AREA OF THE COMPLEX: 41260 ANGSTROM**2 +REMARK 350 CHANGE IN SOLVENT FREE ENERGY: -199.0 KCAL/MOL +REMARK 350 APPLY THE FOLLOWING TO CHAINS: A +REMARK 350 BIOMT1 1 1.000000 0.000000 0.000000 0.00000 +REMARK 350 BIOMT2 1 0.000000 1.000000 0.000000 0.00000 +REMARK 350 BIOMT3 1 0.000000 0.000000 1.000000 0.00000 +REMARK 350 BIOMT1 2 -0.500000 -0.866025 0.000000 0.00000 +REMARK 350 BIOMT2 2 0.866025 -0.500000 0.000000 153.32287 +REMARK 350 BIOMT3 2 0.000000 0.000000 1.000000 0.00000 +REMARK 350 BIOMT1 3 -0.500000 0.866025 0.000000 -132.78150 +REMARK 350 BIOMT2 3 -0.866025 -0.500000 0.000000 76.66143 +REMARK 350 BIOMT3 3 0.000000 0.000000 1.000000 0.00000 +REMARK 350 BIOMT1 4 -0.500000 0.866025 0.000000 -132.78150 +REMARK 350 BIOMT2 4 0.866025 0.500000 0.000000 76.66143 +REMARK 350 BIOMT3 4 0.000000 0.000000 -1.000000 -134.06000 +REMARK 350 BIOMT1 5 1.000000 0.000000 0.000000 0.00000 +REMARK 350 BIOMT2 5 0.000000 -1.000000 0.000000 153.32287 +REMARK 350 BIOMT3 5 0.000000 0.000000 -1.000000 -134.06000 +REMARK 350 BIOMT1 6 -0.500000 -0.866025 0.000000 0.00000 +REMARK 350 BIOMT2 6 -0.866025 0.500000 0.000000 0.00000 +REMARK 350 BIOMT3 6 0.000000 0.000000 -1.000000 -134.06000 +REMARK 375 +REMARK 375 SPECIAL POSITION +REMARK 375 THE FOLLOWING ATOMS ARE FOUND TO BE WITHIN 0.15 ANGSTROMS +REMARK 375 OF A SYMMETRY RELATED ATOM AND ARE ASSUMED TO BE ON SPECIAL +REMARK 375 POSITIONS. +REMARK 375 +REMARK 375 ATOM RES CSSEQI +REMARK 375 MG MG A 194 LIES ON A SPECIAL POSITION. +REMARK 375 CA CA A 196 LIES ON A SPECIAL POSITION. +REMARK 375 HOH A 370 LIES ON A SPECIAL POSITION. +REMARK 375 HOH A 392 LIES ON A SPECIAL POSITION. +REMARK 375 HOH A 396 LIES ON A SPECIAL POSITION. +REMARK 375 HOH A 407 LIES ON A SPECIAL POSITION. +REMARK 375 HOH A 440 LIES ON A SPECIAL POSITION. +REMARK 375 HOH A1486 LIES ON A SPECIAL POSITION. +REMARK 375 HOH A1497 LIES ON A SPECIAL POSITION. +REMARK 470 +REMARK 470 MISSING ATOM +REMARK 470 THE FOLLOWING RESIDUES HAVE MISSING ATOMS (M=MODEL NUMBER; +REMARK 470 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER; +REMARK 470 I=INSERTION CODE): +REMARK 470 M RES CSSEQI ATOMS +REMARK 470 GLU A 62 CG CD OE1 OE2 +REMARK 470 GLU A 63 CG CD OE1 OE2 +REMARK 470 ARG A 128 CG CD NE CZ NH1 NH2 +REMARK 500 +REMARK 500 GEOMETRY AND STEREOCHEMISTRY +REMARK 500 SUBTOPIC: CLOSE CONTACTS IN SAME ASYMMETRIC UNIT +REMARK 500 +REMARK 500 THE FOLLOWING ATOMS ARE IN CLOSE CONTACT. +REMARK 500 +REMARK 500 ATM1 RES C SSEQI ATM2 RES C SSEQI DISTANCE +REMARK 500 O HOH A 360 O HOH A 1481 2.11 +REMARK 500 O GLY A 138 O HOH A 545 2.16 +REMARK 500 O HOH A 1502 O HOH A 1503 2.18 +REMARK 500 +REMARK 500 REMARK: NULL +REMARK 500 +REMARK 500 GEOMETRY AND STEREOCHEMISTRY +REMARK 500 SUBTOPIC: TORSION ANGLES +REMARK 500 +REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS: +REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER; +REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE). +REMARK 500 +REMARK 500 STANDARD TABLE: +REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2) +REMARK 500 +REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI- +REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400 +REMARK 500 +REMARK 500 M RES CSSEQI PSI PHI +REMARK 500 ILE A 36 -85.06 -89.61 +REMARK 500 LYS A 117 34.47 71.28 +REMARK 500 ARG A 149 -2.87 79.93 +REMARK 500 +REMARK 500 REMARK: NULL +REMARK 620 +REMARK 620 METAL COORDINATION +REMARK 620 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER; +REMARK 620 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE): +REMARK 620 +REMARK 620 COORDINATION ANGLES FOR: M RES CSSEQI METAL +REMARK 620 MG A 192 MG +REMARK 620 N RES CSSEQI ATOM +REMARK 620 1 GNP A 190 O2G +REMARK 620 2 GNP A 190 O2B 95.3 +REMARK 620 3 SER A 17 OG 172.7 91.9 +REMARK 620 4 HOH A 544 O 92.3 90.0 86.4 +REMARK 620 5 THR A 35 OG1 90.8 173.9 82.0 90.0 +REMARK 620 6 HOH A 301 O 92.7 90.4 88.5 174.9 89.0 +REMARK 620 N 1 2 3 4 5 +REMARK 620 +REMARK 620 COORDINATION ANGLES FOR: M RES CSSEQI METAL +REMARK 620 CA A 196 CA +REMARK 620 N RES CSSEQI ATOM +REMARK 620 1 ARG A 102 O +REMARK 620 2 ASP A 105 OD1 95.4 +REMARK 620 3 ASP A 105 OD2 84.7 43.9 +REMARK 620 N 1 2 +REMARK 620 +REMARK 620 COORDINATION ANGLES FOR: M RES CSSEQI METAL +REMARK 620 CA A 191 CA +REMARK 620 N RES CSSEQI ATOM +REMARK 620 1 PHE A 28 O +REMARK 620 2 HOH A 309 O 88.8 +REMARK 620 3 ASP A 30 OD1 84.2 84.4 +REMARK 620 4 HOH A1474 O 162.8 90.4 78.6 +REMARK 620 N 1 2 3 +REMARK 620 +REMARK 620 COORDINATION ANGLES FOR: M RES CSSEQI METAL +REMARK 620 MG A 194 MG +REMARK 620 N RES CSSEQI ATOM +REMARK 620 1 HOH A 364 O +REMARK 620 2 HOH A 342 O 75.6 +REMARK 620 3 HOH A 440 O 69.2 126.4 +REMARK 620 N 1 2 +REMARK 800 +REMARK 800 SITE +REMARK 800 SITE_IDENTIFIER: AC1 +REMARK 800 EVIDENCE_CODE: SOFTWARE +REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE CA A 191 +REMARK 800 +REMARK 800 SITE_IDENTIFIER: AC2 +REMARK 800 EVIDENCE_CODE: SOFTWARE +REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE MG A 192 +REMARK 800 +REMARK 800 SITE_IDENTIFIER: AC3 +REMARK 800 EVIDENCE_CODE: SOFTWARE +REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE MG A 194 +REMARK 800 +REMARK 800 SITE_IDENTIFIER: AC4 +REMARK 800 EVIDENCE_CODE: SOFTWARE +REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE DTU A 201 +REMARK 800 +REMARK 800 SITE_IDENTIFIER: AC5 +REMARK 800 EVIDENCE_CODE: SOFTWARE +REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE CA A 196 +REMARK 800 +REMARK 800 SITE_IDENTIFIER: AC6 +REMARK 800 EVIDENCE_CODE: SOFTWARE +REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE GNP A 190 +DBREF 3V4F A 1 166 UNP P20171 RASH_RAT 1 166 +SEQADV 3V4F GLU A 70 UNP P20171 GLN 70 CONFLICT +SEQRES 1 A 166 MET THR GLU TYR LYS LEU VAL VAL VAL GLY ALA GLY GLY +SEQRES 2 A 166 VAL GLY LYS SER ALA LEU THR ILE GLN LEU ILE GLN ASN +SEQRES 3 A 166 HIS PHE VAL ASP GLU TYR ASP PRO THR ILE GLU ASP SER +SEQRES 4 A 166 TYR ARG LYS GLN VAL VAL ILE ASP GLY GLU THR CYS LEU +SEQRES 5 A 166 LEU ASP ILE LEU ASP THR ALA GLY GLN GLU GLU TYR SER +SEQRES 6 A 166 ALA MET ARG ASP GLU TYR MET ARG THR GLY GLU GLY PHE +SEQRES 7 A 166 LEU CYS VAL PHE ALA ILE ASN ASN THR LYS SER PHE GLU +SEQRES 8 A 166 ASP ILE HIS GLN TYR ARG GLU GLN ILE LYS ARG VAL LYS +SEQRES 9 A 166 ASP SER ASP ASP VAL PRO MET VAL LEU VAL GLY ASN LYS +SEQRES 10 A 166 CYS ASP LEU ALA ALA ARG THR VAL GLU SER ARG GLN ALA +SEQRES 11 A 166 GLN ASP LEU ALA ARG SER TYR GLY ILE PRO TYR ILE GLU +SEQRES 12 A 166 THR SER ALA LYS THR ARG GLN GLY VAL GLU ASP ALA PHE +SEQRES 13 A 166 TYR THR LEU VAL ARG GLU ILE ARG GLN HIS +HET CA A 191 1 +HET MG A 192 1 +HET MG A 194 1 +HET DTU A 201 8 +HET CA A 196 1 +HET GNP A 190 32 +HETNAM CA CALCIUM ION +HETNAM MG MAGNESIUM ION +HETNAM DTU (2R,3S)-1,4-DIMERCAPTOBUTANE-2,3-DIOL +HETNAM GNP PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER +FORMUL 2 CA 2(CA 2+) +FORMUL 3 MG 2(MG 2+) +FORMUL 5 DTU C4 H10 O2 S2 +FORMUL 7 GNP C10 H17 N6 O13 P3 +FORMUL 8 HOH *173(H2 O) +HELIX 1 1 GLY A 15 ASN A 26 1 12 +HELIX 2 2 GLN A 61 SER A 65 5 5 +HELIX 3 3 MET A 67 ARG A 73 1 7 +HELIX 4 4 ASN A 86 ASP A 92 1 7 +HELIX 5 5 ASP A 92 ASP A 105 1 14 +HELIX 6 6 GLU A 126 GLY A 138 1 13 +HELIX 7 7 GLY A 151 ARG A 164 1 14 +SHEET 1 A 6 GLU A 37 ILE A 46 0 +SHEET 2 A 6 GLU A 49 THR A 58 -1 O LEU A 53 N LYS A 42 +SHEET 3 A 6 THR A 2 GLY A 10 1 N LEU A 6 O LEU A 56 +SHEET 4 A 6 GLY A 77 ALA A 83 1 O VAL A 81 N VAL A 9 +SHEET 5 A 6 MET A 111 ASN A 116 1 O ASN A 116 N PHE A 82 +SHEET 6 A 6 TYR A 141 GLU A 143 1 O ILE A 142 N LEU A 113 +LINK MG MG A 192 O2G GNP A 190 1555 1555 2.02 +LINK MG MG A 192 O2B GNP A 190 1555 1555 2.09 +LINK OG SER A 17 MG MG A 192 1555 1555 2.12 +LINK MG MG A 192 O HOH A 544 1555 1555 2.13 +LINK OG1 THR A 35 MG MG A 192 1555 1555 2.14 +LINK MG MG A 192 O HOH A 301 1555 1555 2.14 +LINK O ARG A 102 CA CA A 196 1555 1555 2.27 +LINK O PHE A 28 CA CA A 191 1555 1555 2.34 +LINK MG MG A 194 O HOH A 364 1555 1555 2.41 +LINK CA CA A 191 O HOH A 309 1555 1555 2.44 +LINK OD1 ASP A 30 CA CA A 191 1555 1555 2.45 +LINK CA CA A 191 O HOH A1474 1555 1555 2.52 +LINK MG MG A 194 O HOH A 342 1555 1555 2.59 +LINK OD1 ASP A 105 CA CA A 196 1555 1555 2.68 +LINK MG MG A 194 O HOH A 440 1555 1555 2.88 +LINK OD2 ASP A 105 CA CA A 196 1555 1555 3.12 +SITE 1 AC1 6 PHE A 28 ASP A 30 GLU A 31 ASP A 33 +SITE 2 AC1 6 HOH A 309 HOH A1474 +SITE 1 AC2 5 SER A 17 THR A 35 GNP A 190 HOH A 301 +SITE 2 AC2 5 HOH A 544 +SITE 1 AC3 3 HOH A 342 HOH A 364 HOH A 440 +SITE 1 AC4 5 ARG A 68 ASP A 92 GLN A 95 TYR A 96 +SITE 2 AC4 5 GLN A 99 +SITE 1 AC5 2 ARG A 102 ASP A 105 +SITE 1 AC6 32 GLY A 12 GLY A 13 VAL A 14 GLY A 15 +SITE 2 AC6 32 LYS A 16 SER A 17 ALA A 18 PHE A 28 +SITE 3 AC6 32 VAL A 29 ASP A 30 GLU A 31 TYR A 32 +SITE 4 AC6 32 PRO A 34 THR A 35 GLY A 60 GLN A 61 +SITE 5 AC6 32 ASN A 116 LYS A 117 ASP A 119 LEU A 120 +SITE 6 AC6 32 SER A 145 ALA A 146 LYS A 147 HOH A 175 +SITE 7 AC6 32 MG A 192 HOH A 301 HOH A 304 HOH A 327 +SITE 8 AC6 32 HOH A 334 HOH A 390 HOH A 428 HOH A 544 +CRYST1 88.521 88.521 134.060 90.00 90.00 120.00 H 3 2 18 +ORIGX1 1.000000 0.000000 0.000000 0.00000 +ORIGX2 0.000000 1.000000 0.000000 0.00000 +ORIGX3 0.000000 0.000000 1.000000 0.00000 +SCALE1 0.011297 0.006522 0.000000 0.00000 +SCALE2 0.000000 0.013044 0.000000 0.00000 +SCALE3 0.000000 0.000000 0.007459 0.00000 +ATOM 1 N MET A 1 -37.388 77.012 -78.197 1.00 51.19 N +ATOM 2 CA MET A 1 -35.969 76.676 -78.159 1.00 39.13 C +ATOM 3 C MET A 1 -35.754 75.239 -77.696 1.00 39.35 C +ATOM 4 O MET A 1 -36.236 74.830 -76.637 1.00 40.45 O +ATOM 5 CB MET A 1 -35.207 77.645 -77.255 1.00 40.71 C +ATOM 6 CG MET A 1 -33.741 77.293 -77.090 1.00 33.32 C +ATOM 7 SD MET A 1 -32.812 78.532 -76.178 1.00 43.45 S +ATOM 8 CE MET A 1 -33.616 78.448 -74.580 1.00 41.28 C +ATOM 9 N THR A 2 -35.015 74.479 -78.493 1.00 32.32 N +ATOM 10 CA THR A 2 -34.789 73.072 -78.209 1.00 26.31 C +ATOM 11 C THR A 2 -33.547 72.878 -77.344 1.00 22.58 C +ATOM 12 O THR A 2 -32.528 73.512 -77.568 1.00 27.93 O +ATOM 13 CB THR A 2 -34.618 72.281 -79.517 1.00 27.37 C +ATOM 14 OG1 THR A 2 -35.778 72.475 -80.338 1.00 33.63 O +ATOM 15 CG2 THR A 2 -34.455 70.810 -79.227 1.00 28.00 C +ATOM 16 N GLU A 3 -33.634 71.985 -76.373 1.00 18.79 N +ATOM 17 CA GLU A 3 -32.501 71.686 -75.503 1.00 20.66 C +ATOM 18 C GLU A 3 -31.874 70.343 -75.890 1.00 19.96 C +ATOM 19 O GLU A 3 -32.575 69.344 -76.071 1.00 21.15 O +ATOM 20 CB GLU A 3 -32.965 71.664 -74.041 1.00 21.74 C +ATOM 21 CG GLU A 3 -31.852 71.561 -73.011 1.00 23.83 C +ATOM 22 CD GLU A 3 -31.449 70.133 -72.704 1.00 30.29 C +ATOM 23 OE1 GLU A 3 -30.524 69.944 -71.888 1.00 32.91 O +ATOM 24 OE2 GLU A 3 -32.050 69.192 -73.269 1.00 27.85 O +ATOM 25 N TYR A 4 -30.548 70.325 -76.012 1.00 17.28 N +ATOM 26 CA TYR A 4 -29.797 69.089 -76.255 1.00 16.98 C +ATOM 27 C TYR A 4 -28.840 68.855 -75.094 1.00 16.90 C +ATOM 28 O TYR A 4 -28.022 69.723 -74.796 1.00 18.49 O +ATOM 29 CB TYR A 4 -29.009 69.192 -77.566 1.00 15.72 C +ATOM 30 CG TYR A 4 -29.876 69.321 -78.802 1.00 16.50 C +ATOM 31 CD1 TYR A 4 -30.384 68.199 -79.438 1.00 16.47 C +ATOM 32 CD2 TYR A 4 -30.185 70.566 -79.335 1.00 18.19 C +ATOM 33 CE1 TYR A 4 -31.177 68.312 -80.574 1.00 19.03 C +ATOM 34 CE2 TYR A 4 -30.986 70.686 -80.469 1.00 17.09 C +ATOM 35 CZ TYR A 4 -31.473 69.554 -81.081 1.00 16.77 C +ATOM 36 OH TYR A 4 -32.261 69.663 -82.205 1.00 18.55 O +ATOM 37 N LYS A 5 -28.936 67.698 -74.444 1.00 14.97 N +ATOM 38 CA LYS A 5 -28.041 67.373 -73.339 1.00 14.79 C +ATOM 39 C LYS A 5 -26.916 66.479 -73.855 1.00 13.59 C +ATOM 40 O LYS A 5 -27.138 65.314 -74.217 1.00 14.21 O +ATOM 41 CB LYS A 5 -28.798 66.658 -72.210 1.00 18.12 C +ATOM 42 CG LYS A 5 -30.065 67.342 -71.749 1.00 29.93 C +ATOM 43 CD LYS A 5 -30.739 66.566 -70.625 1.00 36.95 C +ATOM 44 CE LYS A 5 -32.004 67.267 -70.143 1.00 44.16 C +ATOM 45 NZ LYS A 5 -33.027 67.376 -71.223 1.00 47.86 N +ATOM 46 N LEU A 6 -25.706 67.027 -73.891 1.00 13.17 N +ATOM 47 CA LEU A 6 -24.554 66.304 -74.425 1.00 13.55 C +ATOM 48 C LEU A 6 -23.633 65.905 -73.288 1.00 12.69 C +ATOM 49 O LEU A 6 -23.441 66.677 -72.340 1.00 16.11 O +ATOM 50 CB LEU A 6 -23.782 67.183 -75.407 1.00 12.63 C +ATOM 51 CG LEU A 6 -24.623 67.931 -76.449 1.00 14.92 C +ATOM 52 CD1 LEU A 6 -23.723 68.723 -77.400 1.00 15.63 C +ATOM 53 CD2 LEU A 6 -25.498 66.976 -77.232 1.00 17.89 C +ATOM 54 N VAL A 7 -23.044 64.722 -73.372 1.00 10.60 N +ATOM 55 CA VAL A 7 -22.136 64.255 -72.343 1.00 11.94 C +ATOM 56 C VAL A 7 -20.805 63.866 -72.987 1.00 12.06 C +ATOM 57 O VAL A 7 -20.791 63.146 -73.988 1.00 12.06 O +ATOM 58 CB VAL A 7 -22.727 63.036 -71.603 1.00 11.76 C +ATOM 59 CG1 VAL A 7 -21.813 62.617 -70.487 1.00 12.37 C +ATOM 60 CG2 VAL A 7 -24.119 63.369 -71.070 1.00 15.12 C +ATOM 61 N VAL A 8 -19.701 64.329 -72.408 1.00 10.42 N +ATOM 62 CA VAL A 8 -18.361 64.097 -72.960 1.00 9.64 C +ATOM 63 C VAL A 8 -17.663 63.095 -72.058 1.00 10.30 C +ATOM 64 O VAL A 8 -17.503 63.347 -70.868 1.00 11.58 O +ATOM 65 CB VAL A 8 -17.559 65.406 -73.032 1.00 9.33 C +ATOM 66 CG1 VAL A 8 -16.224 65.176 -73.731 1.00 11.97 C +ATOM 67 CG2 VAL A 8 -18.366 66.484 -73.773 1.00 11.63 C +ATOM 68 N VAL A 9 -17.283 61.946 -72.620 1.00 9.95 N +ATOM 69 CA VAL A 9 -16.664 60.868 -71.844 1.00 9.73 C +ATOM 70 C VAL A 9 -15.385 60.385 -72.503 1.00 10.83 C +ATOM 71 O VAL A 9 -15.146 60.646 -73.676 1.00 10.82 O +ATOM 72 CB VAL A 9 -17.603 59.646 -71.660 1.00 10.98 C +ATOM 73 CG1 VAL A 9 -18.927 60.061 -70.984 1.00 12.26 C +ATOM 74 CG2 VAL A 9 -17.866 58.955 -73.002 1.00 14.64 C +ATOM 75 N GLY A 10 -14.567 59.667 -71.744 1.00 10.32 N +ATOM 76 CA GLY A 10 -13.294 59.203 -72.250 1.00 11.22 C +ATOM 77 C GLY A 10 -12.235 59.207 -71.166 1.00 11.01 C +ATOM 78 O GLY A 10 -12.435 59.765 -70.089 1.00 11.87 O +ATOM 79 N ALA A 11 -11.096 58.597 -71.464 1.00 10.83 N +ATOM 80 CA ALA A 11 -10.038 58.414 -70.473 1.00 11.25 C +ATOM 81 C ALA A 11 -9.491 59.724 -69.922 1.00 12.93 C +ATOM 82 O ALA A 11 -9.590 60.781 -70.534 1.00 12.02 O +ATOM 83 CB ALA A 11 -8.911 57.597 -71.077 1.00 12.80 C +ATOM 84 N GLY A 12 -8.842 59.636 -68.772 1.00 12.86 N +ATOM 85 CA GLY A 12 -8.242 60.813 -68.175 1.00 12.96 C +ATOM 86 C GLY A 12 -7.191 61.426 -69.075 1.00 11.95 C +ATOM 87 O GLY A 12 -6.353 60.728 -69.643 1.00 14.93 O +ATOM 88 N GLY A 13 -7.235 62.751 -69.219 1.00 11.92 N +ATOM 89 CA GLY A 13 -6.197 63.460 -69.939 1.00 12.55 C +ATOM 90 C GLY A 13 -6.363 63.580 -71.438 1.00 11.09 C +ATOM 91 O GLY A 13 -5.513 64.171 -72.097 1.00 12.48 O +ATOM 92 N VAL A 14 -7.455 63.052 -71.994 1.00 11.09 N +ATOM 93 CA VAL A 14 -7.586 63.058 -73.462 1.00 12.26 C +ATOM 94 C VAL A 14 -8.008 64.405 -74.039 1.00 9.88 C +ATOM 95 O VAL A 14 -7.881 64.626 -75.240 1.00 10.58 O +ATOM 96 CB VAL A 14 -8.532 61.958 -73.988 1.00 10.23 C +ATOM 97 CG1 VAL A 14 -8.023 60.587 -73.559 1.00 11.83 C +ATOM 98 CG2 VAL A 14 -9.949 62.157 -73.485 1.00 11.22 C +ATOM 99 N GLY A 15 -8.487 65.302 -73.173 1.00 10.42 N +ATOM 100 CA GLY A 15 -8.887 66.634 -73.591 1.00 9.85 C +ATOM 101 C GLY A 15 -10.380 66.927 -73.591 1.00 10.16 C +ATOM 102 O GLY A 15 -10.816 67.847 -74.291 1.00 11.27 O +ATOM 103 N LYS A 16 -11.157 66.178 -72.808 1.00 9.38 N +ATOM 104 CA LYS A 16 -12.602 66.427 -72.695 1.00 9.65 C +ATOM 105 C LYS A 16 -12.899 67.857 -72.247 1.00 8.89 C +ATOM 106 O LYS A 16 -13.728 68.541 -72.836 1.00 9.73 O +ATOM 107 CB LYS A 16 -13.242 65.436 -71.715 1.00 9.42 C +ATOM 108 CG LYS A 16 -13.076 63.987 -72.163 1.00 10.91 C +ATOM 109 CD LYS A 16 -13.739 63.010 -71.200 1.00 12.90 C +ATOM 110 CE LYS A 16 -13.130 63.055 -69.817 1.00 13.04 C +ATOM 111 NZ LYS A 16 -11.686 62.654 -69.800 1.00 11.20 N +ATOM 112 N SER A 17 -12.259 68.288 -71.177 1.00 10.40 N +ATOM 113 CA SER A 17 -12.496 69.631 -70.685 1.00 10.18 C +ATOM 114 C SER A 17 -11.997 70.688 -71.649 1.00 10.33 C +ATOM 115 O SER A 17 -12.683 71.677 -71.886 1.00 11.45 O +ATOM 116 CB SER A 17 -11.815 69.805 -69.333 1.00 12.50 C +ATOM 117 OG SER A 17 -12.397 68.926 -68.381 1.00 11.59 O +ATOM 118 N ALA A 18 -10.812 70.488 -72.204 1.00 9.84 N +ATOM 119 CA ALA A 18 -10.287 71.459 -73.136 1.00 10.27 C +ATOM 120 C ALA A 18 -11.188 71.617 -74.362 1.00 9.85 C +ATOM 121 O ALA A 18 -11.377 72.728 -74.875 1.00 11.11 O +ATOM 122 CB ALA A 18 -8.864 71.081 -73.542 1.00 11.52 C +ATOM 123 N LEU A 19 -11.756 70.515 -74.851 1.00 10.43 N +ATOM 124 CA LEU A 19 -12.676 70.593 -75.973 1.00 9.89 C +ATOM 125 C LEU A 19 -13.920 71.396 -75.620 1.00 10.51 C +ATOM 126 O LEU A 19 -14.365 72.248 -76.377 1.00 11.07 O +ATOM 127 CB LEU A 19 -13.095 69.191 -76.429 1.00 10.74 C +ATOM 128 CG LEU A 19 -12.064 68.454 -77.275 1.00 11.98 C +ATOM 129 CD1 LEU A 19 -12.443 66.978 -77.412 1.00 12.48 C +ATOM 130 CD2 LEU A 19 -11.949 69.126 -78.631 1.00 13.57 C +ATOM 131 N THR A 20 -14.485 71.095 -74.461 1.00 9.84 N +ATOM 132 CA THR A 20 -15.715 71.739 -74.021 1.00 11.57 C +ATOM 133 C THR A 20 -15.482 73.226 -73.779 1.00 11.71 C +ATOM 134 O THR A 20 -16.281 74.061 -74.198 1.00 11.63 O +ATOM 135 CB THR A 20 -16.215 71.079 -72.740 1.00 11.55 C +ATOM 136 OG1 THR A 20 -16.423 69.677 -72.985 1.00 13.53 O +ATOM 137 CG2 THR A 20 -17.536 71.698 -72.303 1.00 15.04 C +ATOM 138 N ILE A 21 -14.366 73.557 -73.141 1.00 10.66 N +ATOM 139 CA ILE A 21 -14.061 74.954 -72.844 1.00 11.73 C +ATOM 140 C ILE A 21 -13.752 75.719 -74.130 1.00 11.91 C +ATOM 141 O ILE A 21 -14.138 76.878 -74.259 1.00 12.57 O +ATOM 142 CB ILE A 21 -12.946 75.039 -71.803 1.00 10.44 C +ATOM 143 CG1 ILE A 21 -13.455 74.508 -70.469 1.00 12.15 C +ATOM 144 CG2 ILE A 21 -12.420 76.479 -71.658 1.00 13.57 C +ATOM 145 CD1 ILE A 21 -12.369 74.157 -69.486 1.00 17.15 C +ATOM 146 N GLN A 22 -13.098 75.089 -75.099 1.00 10.90 N +ATOM 147 CA GLN A 22 -12.851 75.746 -76.370 1.00 12.30 C +ATOM 148 C GLN A 22 -14.192 76.053 -77.046 1.00 12.91 C +ATOM 149 O GLN A 22 -14.431 77.178 -77.516 1.00 14.20 O +ATOM 150 CB GLN A 22 -11.953 74.862 -77.252 1.00 13.23 C +ATOM 151 CG GLN A 22 -11.523 75.474 -78.570 1.00 16.07 C +ATOM 152 CD GLN A 22 -10.726 76.752 -78.413 1.00 14.08 C +ATOM 153 OE1 GLN A 22 -11.287 77.844 -78.522 1.00 17.44 O +ATOM 154 NE2 GLN A 22 -9.425 76.633 -78.203 1.00 14.48 N +ATOM 155 N LEU A 23 -15.101 75.081 -77.068 1.00 12.28 N +ATOM 156 CA LEU A 23 -16.413 75.316 -77.668 1.00 12.96 C +ATOM 157 C LEU A 23 -17.173 76.445 -76.981 1.00 14.02 C +ATOM 158 O LEU A 23 -17.734 77.323 -77.651 1.00 16.22 O +ATOM 159 CB LEU A 23 -17.285 74.057 -77.619 1.00 12.12 C +ATOM 160 CG LEU A 23 -18.664 74.226 -78.269 1.00 15.74 C +ATOM 161 CD1 LEU A 23 -18.566 74.100 -79.789 1.00 18.09 C +ATOM 162 CD2 LEU A 23 -19.642 73.202 -77.701 1.00 15.82 C +ATOM 163 N ILE A 24 -17.235 76.402 -75.657 1.00 13.06 N +ATOM 164 CA ILE A 24 -18.119 77.302 -74.914 1.00 13.51 C +ATOM 165 C ILE A 24 -17.487 78.667 -74.647 1.00 14.44 C +ATOM 166 O ILE A 24 -18.177 79.699 -74.717 1.00 15.20 O +ATOM 167 CB ILE A 24 -18.530 76.679 -73.577 1.00 14.08 C +ATOM 168 CG1 ILE A 24 -19.301 75.367 -73.782 1.00 16.18 C +ATOM 169 CG2 ILE A 24 -19.355 77.671 -72.750 1.00 17.13 C +ATOM 170 CD1 ILE A 24 -20.662 75.543 -74.396 1.00 20.00 C +ATOM 171 N GLN A 25 -16.185 78.674 -74.366 1.00 12.88 N +ATOM 172 CA GLN A 25 -15.495 79.892 -73.933 1.00 13.13 C +ATOM 173 C GLN A 25 -14.402 80.404 -74.871 1.00 14.80 C +ATOM 174 O GLN A 25 -13.802 81.450 -74.617 1.00 17.53 O +ATOM 175 CB GLN A 25 -14.902 79.690 -72.536 1.00 14.88 C +ATOM 176 CG GLN A 25 -15.925 79.252 -71.520 1.00 15.68 C +ATOM 177 CD GLN A 25 -15.351 79.094 -70.131 1.00 17.83 C +ATOM 178 OE1 GLN A 25 -14.134 79.164 -69.927 1.00 19.90 O +ATOM 179 NE2 GLN A 25 -16.231 78.874 -69.156 1.00 19.28 N +ATOM 180 N ASN A 26 -14.113 79.668 -75.938 1.00 14.11 N +ATOM 181 CA ASN A 26 -13.217 80.153 -76.983 1.00 13.57 C +ATOM 182 C ASN A 26 -11.796 80.436 -76.525 1.00 16.07 C +ATOM 183 O ASN A 26 -11.163 81.401 -76.969 1.00 18.05 O +ATOM 184 CB ASN A 26 -13.803 81.394 -77.663 1.00 17.40 C +ATOM 185 CG ASN A 26 -15.168 81.144 -78.244 1.00 21.80 C +ATOM 186 OD1 ASN A 26 -15.290 80.533 -79.304 1.00 27.64 O +ATOM 187 ND2 ASN A 26 -16.209 81.605 -77.555 1.00 25.41 N +ATOM 188 N HIS A 27 -11.281 79.595 -75.639 1.00 14.50 N +ATOM 189 CA HIS A 27 -9.858 79.612 -75.345 1.00 13.15 C +ATOM 190 C HIS A 27 -9.383 78.204 -75.025 1.00 13.66 C +ATOM 191 O HIS A 27 -10.185 77.319 -74.726 1.00 12.78 O +ATOM 192 CB HIS A 27 -9.524 80.565 -74.193 1.00 15.15 C +ATOM 193 CG HIS A 27 -10.190 80.209 -72.906 1.00 15.07 C +ATOM 194 ND1 HIS A 27 -9.557 79.518 -71.898 1.00 16.63 N +ATOM 195 CD2 HIS A 27 -11.446 80.445 -72.467 1.00 16.76 C +ATOM 196 CE1 HIS A 27 -10.394 79.351 -70.890 1.00 15.14 C +ATOM 197 NE2 HIS A 27 -11.547 79.904 -71.211 1.00 19.00 N +ATOM 198 N PHE A 28 -8.071 78.023 -75.068 1.00 12.98 N +ATOM 199 CA PHE A 28 -7.439 76.730 -74.828 1.00 12.70 C +ATOM 200 C PHE A 28 -6.891 76.637 -73.410 1.00 12.29 C +ATOM 201 O PHE A 28 -6.110 77.497 -72.992 1.00 13.56 O +ATOM 202 CB PHE A 28 -6.288 76.514 -75.818 1.00 13.40 C +ATOM 203 CG PHE A 28 -5.528 75.229 -75.588 1.00 13.24 C +ATOM 204 CD1 PHE A 28 -6.183 73.998 -75.610 1.00 12.92 C +ATOM 205 CD2 PHE A 28 -4.160 75.248 -75.365 1.00 13.34 C +ATOM 206 CE1 PHE A 28 -5.478 72.812 -75.398 1.00 14.31 C +ATOM 207 CE2 PHE A 28 -3.452 74.069 -75.159 1.00 14.14 C +ATOM 208 CZ PHE A 28 -4.115 72.851 -75.180 1.00 14.41 C +ATOM 209 N VAL A 29 -7.317 75.622 -72.668 1.00 11.58 N +ATOM 210 CA VAL A 29 -6.779 75.368 -71.339 1.00 12.23 C +ATOM 211 C VAL A 29 -5.531 74.515 -71.482 1.00 12.65 C +ATOM 212 O VAL A 29 -5.594 73.359 -71.918 1.00 13.27 O +ATOM 213 CB VAL A 29 -7.819 74.687 -70.426 1.00 13.30 C +ATOM 214 CG1 VAL A 29 -7.213 74.359 -69.068 1.00 16.13 C +ATOM 215 CG2 VAL A 29 -9.031 75.592 -70.251 1.00 19.84 C +ATOM 216 N ASP A 30 -4.392 75.115 -71.152 1.00 12.22 N +ATOM 217 CA ASP A 30 -3.083 74.475 -71.277 1.00 13.01 C +ATOM 218 C ASP A 30 -2.742 73.572 -70.100 1.00 12.10 C +ATOM 219 O ASP A 30 -2.009 72.590 -70.252 1.00 14.41 O +ATOM 220 CB ASP A 30 -1.982 75.540 -71.354 1.00 15.33 C +ATOM 221 CG ASP A 30 -2.095 76.422 -72.577 1.00 16.69 C +ATOM 222 OD1 ASP A 30 -2.930 77.332 -72.583 1.00 16.97 O +ATOM 223 OD2 ASP A 30 -1.328 76.226 -73.544 1.00 19.16 O +ATOM 224 N GLU A 31 -3.221 73.917 -68.909 1.00 14.18 N +ATOM 225 CA GLU A 31 -2.900 73.140 -67.712 1.00 12.68 C +ATOM 226 C GLU A 31 -3.830 71.940 -67.591 1.00 12.81 C +ATOM 227 O GLU A 31 -4.873 71.897 -68.241 1.00 13.17 O +ATOM 228 CB GLU A 31 -3.009 74.009 -66.455 1.00 13.67 C +ATOM 229 CG GLU A 31 -4.428 74.375 -66.101 1.00 14.92 C +ATOM 230 CD GLU A 31 -4.478 75.634 -65.255 1.00 15.82 C +ATOM 231 OE1 GLU A 31 -4.414 76.724 -65.830 1.00 16.49 O +ATOM 232 OE2 GLU A 31 -4.577 75.527 -64.026 1.00 14.27 O +ATOM 233 N TYR A 32 -3.442 70.970 -66.764 1.00 13.69 N +ATOM 234 CA TYR A 32 -4.261 69.785 -66.538 1.00 12.95 C +ATOM 235 C TYR A 32 -4.783 69.740 -65.101 1.00 15.12 C +ATOM 236 O TYR A 32 -4.047 69.383 -64.166 1.00 18.02 O +ATOM 237 CB TYR A 32 -3.468 68.507 -66.872 1.00 14.96 C +ATOM 238 CG TYR A 32 -4.259 67.215 -66.698 1.00 17.06 C +ATOM 239 CD1 TYR A 32 -5.629 67.236 -66.479 1.00 16.75 C +ATOM 240 CD2 TYR A 32 -3.630 65.975 -66.743 1.00 25.58 C +ATOM 241 CE1 TYR A 32 -6.361 66.068 -66.304 1.00 17.17 C +ATOM 242 CE2 TYR A 32 -4.357 64.798 -66.577 1.00 22.05 C +ATOM 243 CZ TYR A 32 -5.720 64.856 -66.355 1.00 19.88 C +ATOM 244 OH TYR A 32 -6.454 63.697 -66.172 1.00 20.28 O +ATOM 245 N ASP A 33 -6.058 70.091 -64.937 1.00 13.80 N +ATOM 246 CA ASP A 33 -6.782 69.925 -63.675 1.00 13.41 C +ATOM 247 C ASP A 33 -7.847 68.851 -63.854 1.00 13.79 C +ATOM 248 O ASP A 33 -8.820 69.068 -64.554 1.00 14.19 O +ATOM 249 CB ASP A 33 -7.453 71.236 -63.251 1.00 14.54 C +ATOM 250 CG ASP A 33 -6.455 72.290 -62.857 1.00 18.86 C +ATOM 251 OD1 ASP A 33 -5.392 71.937 -62.313 1.00 26.04 O +ATOM 252 OD2 ASP A 33 -6.696 73.467 -63.134 1.00 20.82 O +ATOM 253 N PRO A 34 -7.652 67.681 -63.240 1.00 13.56 N +ATOM 254 CA PRO A 34 -8.648 66.619 -63.436 1.00 14.17 C +ATOM 255 C PRO A 34 -10.052 67.025 -63.000 1.00 14.84 C +ATOM 256 O PRO A 34 -10.241 67.687 -61.975 1.00 16.61 O +ATOM 257 CB PRO A 34 -8.118 65.480 -62.564 1.00 16.17 C +ATOM 258 CG PRO A 34 -6.635 65.704 -62.544 1.00 19.56 C +ATOM 259 CD PRO A 34 -6.444 67.202 -62.549 1.00 16.68 C +ATOM 260 N THR A 35 -11.042 66.616 -63.788 1.00 14.33 N +ATOM 261 CA THR A 35 -12.428 66.978 -63.565 1.00 13.34 C +ATOM 262 C THR A 35 -13.112 65.947 -62.685 1.00 15.00 C +ATOM 263 O THR A 35 -12.819 64.752 -62.770 1.00 16.15 O +ATOM 264 CB THR A 35 -13.172 66.997 -64.904 1.00 12.94 C +ATOM 265 OG1 THR A 35 -12.508 67.909 -65.779 1.00 13.49 O +ATOM 266 CG2 THR A 35 -14.641 67.399 -64.750 1.00 15.31 C +ATOM 267 N ILE A 36 -14.021 66.423 -61.842 1.00 17.01 N +ATOM 268 CA ILE A 36 -14.986 65.538 -61.209 1.00 18.94 C +ATOM 269 C ILE A 36 -16.205 65.464 -62.129 1.00 18.84 C +ATOM 270 O ILE A 36 -16.308 64.564 -62.960 1.00 19.35 O +ATOM 271 CB ILE A 36 -15.404 66.053 -59.821 1.00 22.83 C +ATOM 272 CG1 ILE A 36 -14.178 66.474 -59.014 1.00 33.74 C +ATOM 273 CG2 ILE A 36 -16.196 64.982 -59.090 1.00 22.71 C +ATOM 274 CD1 ILE A 36 -13.560 65.352 -58.233 1.00 37.45 C +ATOM 275 N GLU A 37 -17.115 66.423 -61.993 1.00 17.55 N +ATOM 276 CA GLU A 37 -18.255 66.541 -62.893 1.00 17.08 C +ATOM 277 C GLU A 37 -18.620 68.012 -63.037 1.00 18.29 C +ATOM 278 O GLU A 37 -19.050 68.647 -62.067 1.00 20.74 O +ATOM 279 CB GLU A 37 -19.465 65.756 -62.364 1.00 20.73 C +ATOM 280 CG GLU A 37 -19.214 64.261 -62.142 1.00 24.45 C +ATOM 281 CD GLU A 37 -19.017 63.483 -63.439 1.00 23.89 C +ATOM 282 OE1 GLU A 37 -19.521 63.946 -64.487 1.00 23.38 O +ATOM 283 OE2 GLU A 37 -18.351 62.416 -63.407 1.00 22.66 O +ATOM 284 N ASP A 38 -18.440 68.556 -64.239 1.00 14.83 N +ATOM 285 CA ASP A 38 -18.750 69.961 -64.497 1.00 14.84 C +ATOM 286 C ASP A 38 -19.811 70.085 -65.583 1.00 15.22 C +ATOM 287 O ASP A 38 -19.916 69.231 -66.460 1.00 18.23 O +ATOM 288 CB ASP A 38 -17.501 70.716 -64.954 1.00 16.68 C +ATOM 289 CG ASP A 38 -16.418 70.779 -63.890 1.00 18.37 C +ATOM 290 OD1 ASP A 38 -16.743 70.695 -62.686 1.00 19.61 O +ATOM 291 OD2 ASP A 38 -15.242 70.917 -64.271 1.00 19.74 O +ATOM 292 N SER A 39 -20.604 71.142 -65.536 1.00 14.67 N +ATOM 293 CA SER A 39 -21.599 71.368 -66.574 1.00 15.34 C +ATOM 294 C SER A 39 -21.494 72.770 -67.159 1.00 14.70 C +ATOM 295 O SER A 39 -21.103 73.725 -66.475 1.00 16.25 O +ATOM 296 CB SER A 39 -23.007 71.144 -66.029 1.00 19.56 C +ATOM 297 OG SER A 39 -23.267 72.028 -64.966 1.00 28.28 O +ATOM 298 N TYR A 40 -21.871 72.892 -68.427 1.00 14.20 N +ATOM 299 CA TYR A 40 -21.832 74.143 -69.161 1.00 14.18 C +ATOM 300 C TYR A 40 -23.129 74.277 -69.927 1.00 15.90 C +ATOM 301 O TYR A 40 -23.703 73.279 -70.349 1.00 16.04 O +ATOM 302 CB TYR A 40 -20.667 74.168 -70.150 1.00 16.55 C +ATOM 303 CG TYR A 40 -19.313 74.063 -69.509 1.00 15.81 C +ATOM 304 CD1 TYR A 40 -18.771 72.827 -69.189 1.00 14.84 C +ATOM 305 CD2 TYR A 40 -18.578 75.201 -69.213 1.00 16.62 C +ATOM 306 CE1 TYR A 40 -17.519 72.719 -68.595 1.00 15.48 C +ATOM 307 CE2 TYR A 40 -17.328 75.108 -68.626 1.00 16.05 C +ATOM 308 CZ TYR A 40 -16.807 73.870 -68.315 1.00 17.33 C +ATOM 309 OH TYR A 40 -15.560 73.775 -67.730 1.00 20.43 O +ATOM 310 N ARG A 41 -23.594 75.501 -70.111 1.00 15.58 N +ATOM 311 CA ARG A 41 -24.801 75.742 -70.868 1.00 16.58 C +ATOM 312 C ARG A 41 -24.543 76.892 -71.825 1.00 21.21 C +ATOM 313 O ARG A 41 -23.903 77.883 -71.464 1.00 22.58 O +ATOM 314 CB ARG A 41 -25.956 76.070 -69.918 1.00 22.28 C +ATOM 315 CG ARG A 41 -27.160 76.689 -70.589 1.00 27.88 C +ATOM 316 CD ARG A 41 -28.330 76.802 -69.621 1.00 36.63 C +ATOM 317 NE ARG A 41 -28.998 75.519 -69.429 1.00 36.60 N +ATOM 318 CZ ARG A 41 -30.237 75.386 -68.968 1.00 37.20 C +ATOM 319 NH1 ARG A 41 -30.948 76.462 -68.651 1.00 37.46 N +ATOM 320 NH2 ARG A 41 -30.769 74.179 -68.833 1.00 33.53 N +ATOM 321 N LYS A 42 -25.027 76.771 -73.053 1.00 17.78 N +ATOM 322 CA LYS A 42 -24.869 77.854 -74.011 1.00 20.02 C +ATOM 323 C LYS A 42 -25.968 77.772 -75.050 1.00 18.54 C +ATOM 324 O LYS A 42 -26.319 76.689 -75.507 1.00 16.58 O +ATOM 325 CB LYS A 42 -23.504 77.766 -74.689 1.00 25.15 C +ATOM 326 CG LYS A 42 -23.084 79.007 -75.464 1.00 30.08 C +ATOM 327 CD LYS A 42 -21.739 78.774 -76.145 1.00 33.95 C +ATOM 328 CE LYS A 42 -21.103 80.083 -76.608 1.00 39.77 C +ATOM 329 NZ LYS A 42 -19.825 79.857 -77.351 1.00 37.39 N +ATOM 330 N GLN A 43 -26.517 78.924 -75.403 1.00 19.90 N +ATOM 331 CA GLN A 43 -27.494 79.014 -76.469 1.00 18.41 C +ATOM 332 C GLN A 43 -26.743 79.253 -77.768 1.00 19.64 C +ATOM 333 O GLN A 43 -25.905 80.152 -77.862 1.00 20.98 O +ATOM 334 CB GLN A 43 -28.438 80.172 -76.170 1.00 22.06 C +ATOM 335 CG GLN A 43 -29.589 80.344 -77.144 1.00 29.67 C +ATOM 336 CD GLN A 43 -30.517 81.474 -76.725 1.00 34.18 C +ATOM 337 OE1 GLN A 43 -30.889 81.583 -75.555 1.00 36.51 O +ATOM 338 NE2 GLN A 43 -30.878 82.326 -77.674 1.00 44.79 N +ATOM 339 N VAL A 44 -27.038 78.429 -78.767 1.00 20.72 N +ATOM 340 CA VAL A 44 -26.363 78.509 -80.054 1.00 21.56 C +ATOM 341 C VAL A 44 -27.362 78.229 -81.170 1.00 20.59 C +ATOM 342 O VAL A 44 -28.386 77.587 -80.946 1.00 24.49 O +ATOM 343 CB VAL A 44 -25.225 77.473 -80.145 1.00 20.65 C +ATOM 344 CG1 VAL A 44 -24.181 77.714 -79.059 1.00 30.60 C +ATOM 345 CG2 VAL A 44 -25.783 76.077 -80.020 1.00 25.30 C +ATOM 346 N VAL A 45 -27.071 78.713 -82.368 1.00 18.80 N +ATOM 347 CA VAL A 45 -27.896 78.393 -83.523 1.00 19.45 C +ATOM 348 C VAL A 45 -27.185 77.311 -84.328 1.00 16.14 C +ATOM 349 O VAL A 45 -26.043 77.485 -84.740 1.00 18.70 O +ATOM 350 CB VAL A 45 -28.150 79.629 -84.413 1.00 21.59 C +ATOM 351 CG1 VAL A 45 -29.070 79.262 -85.565 1.00 21.79 C +ATOM 352 CG2 VAL A 45 -28.758 80.761 -83.596 1.00 27.71 C +ATOM 353 N ILE A 46 -27.849 76.177 -84.507 1.00 16.45 N +ATOM 354 CA ILE A 46 -27.251 75.053 -85.217 1.00 15.88 C +ATOM 355 C ILE A 46 -28.186 74.695 -86.351 1.00 17.52 C +ATOM 356 O ILE A 46 -29.321 74.309 -86.126 1.00 17.15 O +ATOM 357 CB ILE A 46 -27.041 73.833 -84.290 1.00 17.46 C +ATOM 358 CG1 ILE A 46 -26.118 74.197 -83.126 1.00 17.12 C +ATOM 359 CG2 ILE A 46 -26.416 72.645 -85.050 1.00 17.36 C +ATOM 360 CD1 ILE A 46 -25.957 73.069 -82.118 1.00 17.70 C +ATOM 361 N ASP A 47 -27.705 74.864 -87.580 1.00 17.82 N +ATOM 362 CA ASP A 47 -28.523 74.614 -88.766 1.00 18.16 C +ATOM 363 C ASP A 47 -29.850 75.363 -88.709 1.00 19.32 C +ATOM 364 O ASP A 47 -30.892 74.815 -89.044 1.00 22.43 O +ATOM 365 CB ASP A 47 -28.745 73.105 -88.963 1.00 19.14 C +ATOM 366 CG ASP A 47 -27.447 72.336 -88.964 1.00 21.29 C +ATOM 367 OD1 ASP A 47 -26.533 72.710 -89.728 1.00 19.19 O +ATOM 368 OD2 ASP A 47 -27.313 71.370 -88.172 1.00 20.05 O +ATOM 369 N GLY A 48 -29.806 76.622 -88.276 1.00 19.74 N +ATOM 370 CA GLY A 48 -30.976 77.481 -88.307 1.00 20.11 C +ATOM 371 C GLY A 48 -31.921 77.327 -87.129 1.00 25.25 C +ATOM 372 O GLY A 48 -32.911 78.048 -87.012 1.00 28.41 O +ATOM 373 N GLU A 49 -31.614 76.379 -86.250 1.00 21.25 N +ATOM 374 CA GLU A 49 -32.420 76.154 -85.058 1.00 22.64 C +ATOM 375 C GLU A 49 -31.747 76.774 -83.836 1.00 19.54 C +ATOM 376 O GLU A 49 -30.584 76.502 -83.549 1.00 18.32 O +ATOM 377 CB GLU A 49 -32.624 74.652 -84.833 1.00 21.26 C +ATOM 378 CG GLU A 49 -33.416 74.324 -83.582 1.00 23.17 C +ATOM 379 CD GLU A 49 -33.642 72.834 -83.397 1.00 28.26 C +ATOM 380 OE1 GLU A 49 -32.649 72.085 -83.274 1.00 26.28 O +ATOM 381 OE2 GLU A 49 -34.814 72.408 -83.370 1.00 38.28 O +ATOM 382 N THR A 50 -32.466 77.637 -83.134 1.00 22.37 N +ATOM 383 CA THR A 50 -31.952 78.168 -81.885 1.00 21.32 C +ATOM 384 C THR A 50 -32.102 77.089 -80.830 1.00 23.62 C +ATOM 385 O THR A 50 -33.179 76.537 -80.641 1.00 25.97 O +ATOM 386 CB THR A 50 -32.696 79.444 -81.454 1.00 28.49 C +ATOM 387 OG1 THR A 50 -32.496 80.460 -82.442 1.00 31.90 O +ATOM 388 CG2 THR A 50 -32.156 79.943 -80.128 1.00 31.39 C +ATOM 389 N CYS A 51 -31.020 76.757 -80.151 1.00 20.86 N +ATOM 390 CA CYS A 51 -31.151 75.747 -79.131 1.00 27.87 C +ATOM 391 C CYS A 51 -30.207 75.955 -77.974 1.00 22.11 C +ATOM 392 O CYS A 51 -29.292 76.781 -78.022 1.00 22.41 O +ATOM 393 CB CYS A 51 -30.947 74.369 -79.728 1.00 26.89 C +ATOM 394 SG CYS A 51 -29.325 74.209 -80.406 1.00 29.86 S +ATOM 395 N LEU A 52 -30.458 75.182 -76.932 1.00 17.15 N +ATOM 396 CA LEU A 52 -29.748 75.305 -75.680 1.00 16.34 C +ATOM 397 C LEU A 52 -28.939 74.042 -75.499 1.00 18.45 C +ATOM 398 O LEU A 52 -29.502 72.960 -75.390 1.00 19.85 O +ATOM 399 CB LEU A 52 -30.770 75.450 -74.549 1.00 20.18 C +ATOM 400 CG LEU A 52 -30.224 75.638 -73.136 1.00 25.39 C +ATOM 401 CD1 LEU A 52 -29.548 77.000 -73.019 1.00 28.85 C +ATOM 402 CD2 LEU A 52 -31.363 75.498 -72.133 1.00 30.02 C +ATOM 403 N LEU A 53 -27.619 74.172 -75.490 1.00 15.59 N +ATOM 404 CA LEU A 53 -26.768 73.021 -75.216 1.00 15.60 C +ATOM 405 C LEU A 53 -26.441 72.934 -73.740 1.00 17.08 C +ATOM 406 O LEU A 53 -25.957 73.903 -73.154 1.00 18.56 O +ATOM 407 CB LEU A 53 -25.462 73.096 -76.008 1.00 18.49 C +ATOM 408 CG LEU A 53 -25.604 73.234 -77.522 1.00 18.19 C +ATOM 409 CD1 LEU A 53 -24.229 73.158 -78.175 1.00 18.63 C +ATOM 410 CD2 LEU A 53 -26.529 72.151 -78.074 1.00 19.64 C +ATOM 411 N ASP A 54 -26.705 71.782 -73.138 1.00 14.85 N +ATOM 412 CA ASP A 54 -26.248 71.511 -71.788 1.00 15.47 C +ATOM 413 C ASP A 54 -25.178 70.455 -71.936 1.00 16.57 C +ATOM 414 O ASP A 54 -25.476 69.336 -72.347 1.00 17.60 O +ATOM 415 CB ASP A 54 -27.382 70.974 -70.910 1.00 19.81 C +ATOM 416 CG ASP A 54 -28.326 72.060 -70.439 1.00 24.30 C +ATOM 417 OD1 ASP A 54 -27.875 72.959 -69.701 1.00 27.26 O +ATOM 418 OD2 ASP A 54 -29.519 72.005 -70.798 1.00 29.88 O +ATOM 419 N ILE A 55 -23.938 70.808 -71.629 1.00 13.35 N +ATOM 420 CA ILE A 55 -22.821 69.894 -71.825 1.00 12.42 C +ATOM 421 C ILE A 55 -22.282 69.446 -70.482 1.00 13.88 C +ATOM 422 O ILE A 55 -21.913 70.271 -69.637 1.00 15.21 O +ATOM 423 CB ILE A 55 -21.701 70.525 -72.680 1.00 13.46 C +ATOM 424 CG1 ILE A 55 -22.286 71.014 -74.010 1.00 17.07 C +ATOM 425 CG2 ILE A 55 -20.548 69.523 -72.882 1.00 16.86 C +ATOM 426 CD1 ILE A 55 -21.294 71.691 -74.895 1.00 18.24 C +ATOM 427 N LEU A 56 -22.243 68.138 -70.277 1.00 13.42 N +ATOM 428 CA ALEU A 56 -21.681 67.567 -69.066 0.54 14.04 C +ATOM 429 CA BLEU A 56 -21.676 67.584 -69.065 0.46 14.05 C +ATOM 430 C LEU A 56 -20.287 67.053 -69.364 1.00 13.12 C +ATOM 431 O LEU A 56 -20.109 66.199 -70.236 1.00 13.60 O +ATOM 432 CB ALEU A 56 -22.552 66.421 -68.545 0.54 15.64 C +ATOM 433 CB BLEU A 56 -22.573 66.480 -68.509 0.46 15.65 C +ATOM 434 CG ALEU A 56 -23.996 66.733 -68.157 0.54 18.36 C +ATOM 435 CG BLEU A 56 -22.104 65.758 -67.247 0.46 16.39 C +ATOM 436 CD1ALEU A 56 -24.614 65.519 -67.470 0.54 23.66 C +ATOM 437 CD1BLEU A 56 -21.687 66.725 -66.150 0.46 22.44 C +ATOM 438 CD2ALEU A 56 -24.057 67.951 -67.258 0.54 22.90 C +ATOM 439 CD2BLEU A 56 -23.220 64.855 -66.766 0.46 24.60 C +ATOM 440 N ASP A 57 -19.315 67.591 -68.648 1.00 14.18 N +ATOM 441 CA ASP A 57 -17.920 67.236 -68.783 1.00 13.94 C +ATOM 442 C ASP A 57 -17.607 66.302 -67.621 1.00 13.99 C +ATOM 443 O ASP A 57 -17.692 66.690 -66.458 1.00 17.12 O +ATOM 444 CB ASP A 57 -17.116 68.534 -68.697 1.00 14.82 C +ATOM 445 CG ASP A 57 -15.643 68.328 -68.837 1.00 15.36 C +ATOM 446 OD1 ASP A 57 -15.233 67.280 -69.371 1.00 17.89 O +ATOM 447 OD2 ASP A 57 -14.896 69.240 -68.418 1.00 17.64 O +ATOM 448 N THR A 58 -17.288 65.056 -67.934 1.00 14.15 N +ATOM 449 CA THR A 58 -17.172 64.033 -66.908 1.00 14.49 C +ATOM 450 C THR A 58 -15.722 63.700 -66.572 1.00 14.46 C +ATOM 451 O THR A 58 -14.794 64.031 -67.310 1.00 14.48 O +ATOM 452 CB THR A 58 -17.878 62.734 -67.341 1.00 14.20 C +ATOM 453 OG1 THR A 58 -17.151 62.137 -68.429 1.00 14.49 O +ATOM 454 CG2 THR A 58 -19.319 63.014 -67.776 1.00 17.19 C +ATOM 455 N ALA A 59 -15.533 63.006 -65.457 1.00 15.05 N +ATOM 456 CA ALA A 59 -14.222 62.548 -65.034 1.00 14.67 C +ATOM 457 C ALA A 59 -13.738 61.381 -65.872 1.00 15.74 C +ATOM 458 O ALA A 59 -14.482 60.430 -66.116 1.00 18.48 O +ATOM 459 CB ALA A 59 -14.277 62.125 -63.563 1.00 18.66 C +ATOM 460 N GLY A 60 -12.486 61.439 -66.300 1.00 14.45 N +ATOM 461 CA GLY A 60 -11.854 60.281 -66.891 1.00 15.30 C +ATOM 462 C GLY A 60 -10.896 59.566 -65.952 1.00 19.57 C +ATOM 463 O GLY A 60 -10.543 58.411 -66.187 1.00 21.19 O +ATOM 464 N GLN A 61 -10.454 60.249 -64.899 1.00 18.27 N +ATOM 465 CA GLN A 61 -9.585 59.601 -63.917 1.00 22.92 C +ATOM 466 C GLN A 61 -10.424 58.697 -63.022 1.00 23.75 C +ATOM 467 O GLN A 61 -11.438 59.123 -62.484 1.00 25.66 O +ATOM 468 CB GLN A 61 -8.817 60.630 -63.075 1.00 22.29 C +ATOM 469 CG GLN A 61 -7.763 61.411 -63.843 1.00 21.78 C +ATOM 470 CD GLN A 61 -6.626 60.542 -64.349 1.00 27.48 C +ATOM 471 OE1 GLN A 61 -6.402 59.428 -63.861 1.00 32.15 O +ATOM 472 NE2 GLN A 61 -5.892 61.053 -65.333 1.00 26.79 N +ATOM 473 N GLU A 62 -10.005 57.440 -62.885 1.00 25.94 N +ATOM 474 CA GLU A 62 -10.752 56.470 -62.090 1.00 29.17 C +ATOM 475 C GLU A 62 -11.021 57.014 -60.689 1.00 30.62 C +ATOM 476 O GLU A 62 -12.117 56.858 -60.147 1.00 32.14 O +ATOM 477 CB GLU A 62 -9.989 55.144 -62.009 1.00 31.33 C +ATOM 478 N GLU A 63 -10.014 57.669 -60.121 1.00 30.85 N +ATOM 479 CA GLU A 63 -10.108 58.249 -58.783 1.00 34.87 C +ATOM 480 C GLU A 63 -11.241 59.264 -58.643 1.00 37.33 C +ATOM 481 O GLU A 63 -11.861 59.374 -57.583 1.00 32.90 O +ATOM 482 CB GLU A 63 -8.782 58.914 -58.407 1.00 33.59 C +ATOM 483 N TYR A 64 -11.506 60.008 -59.713 1.00 32.79 N +ATOM 484 CA TYR A 64 -12.510 61.064 -59.678 1.00 29.28 C +ATOM 485 C TYR A 64 -13.858 60.610 -60.244 1.00 28.76 C +ATOM 486 O TYR A 64 -14.786 61.412 -60.349 1.00 29.10 O +ATOM 487 CB TYR A 64 -12.030 62.288 -60.473 1.00 26.37 C +ATOM 488 CG TYR A 64 -10.793 62.987 -59.937 1.00 33.20 C +ATOM 489 CD1 TYR A 64 -9.536 62.409 -60.046 1.00 37.45 C +ATOM 490 CD2 TYR A 64 -10.882 64.248 -59.361 1.00 37.54 C +ATOM 491 CE1 TYR A 64 -8.408 63.053 -59.568 1.00 37.30 C +ATOM 492 CE2 TYR A 64 -9.759 64.904 -58.880 1.00 38.51 C +ATOM 493 CZ TYR A 64 -8.524 64.299 -58.986 1.00 47.32 C +ATOM 494 OH TYR A 64 -7.402 64.945 -58.511 1.00 54.98 O +ATOM 495 N SER A 65 -13.966 59.333 -60.603 1.00 29.33 N +ATOM 496 CA SER A 65 -15.109 58.859 -61.392 1.00 32.06 C +ATOM 497 C SER A 65 -16.335 58.421 -60.586 1.00 34.05 C +ATOM 498 O SER A 65 -17.269 57.848 -61.148 1.00 30.96 O +ATOM 499 CB SER A 65 -14.682 57.726 -62.332 1.00 33.71 C +ATOM 500 OG SER A 65 -14.313 56.563 -61.604 1.00 38.38 O +ATOM 501 N ALA A 66 -16.337 58.692 -59.285 1.00 33.83 N +ATOM 502 CA ALA A 66 -17.481 58.345 -58.444 1.00 38.39 C +ATOM 503 C ALA A 66 -18.781 58.915 -59.003 1.00 35.62 C +ATOM 504 O ALA A 66 -18.894 60.118 -59.228 1.00 38.81 O +ATOM 505 CB ALA A 66 -17.262 58.832 -57.016 1.00 39.99 C +ATOM 506 N MET A 67 -19.753 58.037 -59.229 1.00 38.11 N +ATOM 507 CA MET A 67 -21.096 58.442 -59.642 1.00 38.00 C +ATOM 508 C MET A 67 -21.177 58.961 -61.073 1.00 28.88 C +ATOM 509 O MET A 67 -22.173 59.580 -61.446 1.00 33.19 O +ATOM 510 CB MET A 67 -21.665 59.508 -58.701 1.00 43.36 C +ATOM 511 CG MET A 67 -21.566 59.177 -57.223 1.00 51.54 C +ATOM 512 SD MET A 67 -22.621 60.262 -56.244 1.00 64.82 S +ATOM 513 CE MET A 67 -22.602 61.752 -57.240 1.00 51.20 C +ATOM 514 N ARG A 68 -20.144 58.720 -61.874 1.00 31.10 N +ATOM 515 CA ARG A 68 -20.186 59.170 -63.258 1.00 27.64 C +ATOM 516 C ARG A 68 -21.409 58.594 -63.962 1.00 28.38 C +ATOM 517 O ARG A 68 -22.056 59.276 -64.753 1.00 26.04 O +ATOM 518 CB ARG A 68 -18.901 58.813 -64.010 1.00 25.76 C +ATOM 519 CG ARG A 68 -18.828 59.434 -65.402 1.00 25.92 C +ATOM 520 CD ARG A 68 -17.497 59.141 -66.083 1.00 23.77 C +ATOM 521 NE ARG A 68 -17.345 57.721 -66.377 1.00 25.93 N +ATOM 522 CZ ARG A 68 -16.223 57.031 -66.204 1.00 23.91 C +ATOM 523 NH1 ARG A 68 -15.127 57.622 -65.745 1.00 23.11 N +ATOM 524 NH2 ARG A 68 -16.197 55.736 -66.493 1.00 29.35 N +ATOM 525 N ASP A 69 -21.749 57.347 -63.652 1.00 29.53 N +ATOM 526 CA ASP A 69 -22.903 56.707 -64.285 1.00 27.23 C +ATOM 527 C ASP A 69 -24.221 57.450 -64.045 1.00 26.10 C +ATOM 528 O ASP A 69 -25.077 57.498 -64.927 1.00 26.79 O +ATOM 529 CB ASP A 69 -23.014 55.229 -63.885 1.00 31.37 C +ATOM 530 CG ASP A 69 -22.889 55.008 -62.386 1.00 44.85 C +ATOM 531 OD1 ASP A 69 -22.156 55.769 -61.716 1.00 43.31 O +ATOM 532 OD2 ASP A 69 -23.520 54.055 -61.878 1.00 51.05 O +ATOM 533 N GLU A 70 -24.383 58.032 -62.860 1.00 26.81 N +ATOM 534 CA GLU A 70 -25.570 58.828 -62.552 1.00 31.06 C +ATOM 535 C GLU A 70 -25.676 60.067 -63.440 1.00 30.80 C +ATOM 536 O GLU A 70 -26.776 60.517 -63.772 1.00 30.22 O +ATOM 537 CB GLU A 70 -25.572 59.243 -61.080 1.00 36.10 C +ATOM 538 CG GLU A 70 -26.184 58.212 -60.152 1.00 40.04 C +ATOM 539 CD GLU A 70 -25.507 56.864 -60.255 1.00 44.34 C +ATOM 540 OE1 GLU A 70 -24.293 56.786 -59.963 1.00 52.09 O +ATOM 541 OE2 GLU A 70 -26.185 55.881 -60.631 1.00 49.04 O +ATOM 542 N TYR A 71 -24.525 60.616 -63.815 1.00 28.71 N +ATOM 543 CA TYR A 71 -24.481 61.751 -64.736 1.00 29.21 C +ATOM 544 C TYR A 71 -24.703 61.323 -66.189 1.00 24.08 C +ATOM 545 O TYR A 71 -25.486 61.938 -66.918 1.00 28.01 O +ATOM 546 CB TYR A 71 -23.152 62.501 -64.586 1.00 27.33 C +ATOM 547 CG TYR A 71 -23.050 63.271 -63.292 1.00 26.90 C +ATOM 548 CD1 TYR A 71 -22.648 62.642 -62.120 1.00 35.29 C +ATOM 549 CD2 TYR A 71 -23.360 64.626 -63.237 1.00 31.54 C +ATOM 550 CE1 TYR A 71 -22.559 63.337 -60.929 1.00 35.13 C +ATOM 551 CE2 TYR A 71 -23.270 65.333 -62.047 1.00 33.89 C +ATOM 552 CZ TYR A 71 -22.871 64.680 -60.898 1.00 35.50 C +ATOM 553 OH TYR A 71 -22.780 65.370 -59.710 1.00 41.79 O +ATOM 554 N MET A 72 -24.013 60.273 -66.615 1.00 25.61 N +ATOM 555 CA MET A 72 -24.157 59.787 -67.982 1.00 20.65 C +ATOM 556 C MET A 72 -25.613 59.410 -68.304 1.00 27.86 C +ATOM 557 O MET A 72 -26.074 59.564 -69.430 1.00 25.22 O +ATOM 558 CB MET A 72 -23.204 58.615 -68.247 1.00 24.53 C +ATOM 559 CG MET A 72 -21.714 58.969 -68.113 1.00 20.38 C +ATOM 560 SD MET A 72 -20.626 57.538 -68.151 1.00 26.92 S +ATOM 561 CE MET A 72 -20.924 56.920 -69.809 1.00 26.89 C +ATOM 562 N ARG A 73 -26.340 58.930 -67.301 1.00 27.58 N +ATOM 563 CA ARG A 73 -27.716 58.476 -67.480 1.00 26.07 C +ATOM 564 C ARG A 73 -28.648 59.542 -68.067 1.00 26.33 C +ATOM 565 O ARG A 73 -29.616 59.226 -68.766 1.00 24.62 O +ATOM 566 CB ARG A 73 -28.257 57.981 -66.135 1.00 28.63 C +ATOM 567 CG ARG A 73 -29.726 57.636 -66.136 1.00 35.05 C +ATOM 568 CD ARG A 73 -30.211 57.277 -64.734 1.00 38.15 C +ATOM 569 NE ARG A 73 -31.630 56.952 -64.762 1.00 37.43 N +ATOM 570 CZ ARG A 73 -32.109 55.787 -65.176 1.00 32.19 C +ATOM 571 NH1 ARG A 73 -31.278 54.841 -65.588 1.00 35.58 N +ATOM 572 NH2 ARG A 73 -33.414 55.571 -65.185 1.00 33.19 N +ATOM 573 N THR A 74 -28.336 60.804 -67.799 1.00 28.75 N +ATOM 574 CA THR A 74 -29.190 61.919 -68.186 1.00 23.81 C +ATOM 575 C THR A 74 -28.979 62.373 -69.646 1.00 24.17 C +ATOM 576 O THR A 74 -29.795 63.105 -70.210 1.00 27.47 O +ATOM 577 CB THR A 74 -28.949 63.130 -67.251 1.00 28.14 C +ATOM 578 OG1 THR A 74 -27.657 63.694 -67.518 1.00 30.01 O +ATOM 579 CG2 THR A 74 -28.994 62.694 -65.790 1.00 27.71 C +ATOM 580 N GLY A 75 -27.897 61.921 -70.258 1.00 21.63 N +ATOM 581 CA GLY A 75 -27.509 62.447 -71.557 1.00 17.75 C +ATOM 582 C GLY A 75 -28.329 61.966 -72.741 1.00 16.95 C +ATOM 583 O GLY A 75 -28.807 60.822 -72.769 1.00 18.41 O +ATOM 584 N GLU A 76 -28.467 62.833 -73.736 1.00 15.28 N +ATOM 585 CA GLU A 76 -29.161 62.502 -74.971 1.00 14.73 C +ATOM 586 C GLU A 76 -28.191 62.073 -76.069 1.00 14.00 C +ATOM 587 O GLU A 76 -28.582 61.367 -76.996 1.00 15.95 O +ATOM 588 CB GLU A 76 -30.003 63.687 -75.426 1.00 14.41 C +ATOM 589 CG GLU A 76 -31.173 63.933 -74.472 1.00 19.67 C +ATOM 590 CD GLU A 76 -31.911 65.244 -74.695 1.00 30.51 C +ATOM 591 OE1 GLU A 76 -31.299 66.239 -75.136 1.00 22.59 O +ATOM 592 OE2 GLU A 76 -33.128 65.284 -74.405 1.00 36.91 O +ATOM 593 N GLY A 77 -26.926 62.480 -75.951 1.00 12.79 N +ATOM 594 CA GLY A 77 -25.907 62.099 -76.925 1.00 13.65 C +ATOM 595 C GLY A 77 -24.558 62.178 -76.253 1.00 11.43 C +ATOM 596 O GLY A 77 -24.393 62.934 -75.301 1.00 11.87 O +ATOM 597 N PHE A 78 -23.611 61.378 -76.729 1.00 10.21 N +ATOM 598 CA PHE A 78 -22.303 61.258 -76.090 1.00 9.46 C +ATOM 599 C PHE A 78 -21.170 61.486 -77.071 1.00 10.05 C +ATOM 600 O PHE A 78 -21.164 60.921 -78.156 1.00 11.26 O +ATOM 601 CB PHE A 78 -22.173 59.864 -75.443 1.00 12.91 C +ATOM 602 CG PHE A 78 -23.183 59.624 -74.360 1.00 13.39 C +ATOM 603 CD1 PHE A 78 -24.505 59.333 -74.671 1.00 15.09 C +ATOM 604 CD2 PHE A 78 -22.828 59.748 -73.035 1.00 13.99 C +ATOM 605 CE1 PHE A 78 -25.459 59.151 -73.668 1.00 15.98 C +ATOM 606 CE2 PHE A 78 -23.782 59.560 -72.016 1.00 16.86 C +ATOM 607 CZ PHE A 78 -25.095 59.268 -72.342 1.00 18.82 C +ATOM 608 N LEU A 79 -20.212 62.321 -76.669 1.00 10.05 N +ATOM 609 CA LEU A 79 -18.932 62.423 -77.374 1.00 10.09 C +ATOM 610 C LEU A 79 -17.997 61.473 -76.685 1.00 11.87 C +ATOM 611 O LEU A 79 -17.718 61.634 -75.496 1.00 14.05 O +ATOM 612 CB LEU A 79 -18.356 63.827 -77.239 1.00 15.01 C +ATOM 613 CG LEU A 79 -18.785 64.954 -78.158 1.00 19.13 C +ATOM 614 CD1 LEU A 79 -17.739 66.073 -78.056 1.00 18.31 C +ATOM 615 CD2 LEU A 79 -18.980 64.505 -79.611 1.00 14.32 C +ATOM 616 N CYS A 80 -17.516 60.472 -77.419 1.00 10.43 N +ATOM 617 CA CYS A 80 -16.586 59.497 -76.871 1.00 11.39 C +ATOM 618 C CYS A 80 -15.203 59.863 -77.348 1.00 9.90 C +ATOM 619 O CYS A 80 -14.894 59.707 -78.529 1.00 10.79 O +ATOM 620 CB CYS A 80 -16.943 58.104 -77.355 1.00 11.56 C +ATOM 621 SG CYS A 80 -18.549 57.551 -76.751 1.00 18.98 S +ATOM 622 N VAL A 81 -14.386 60.377 -76.430 1.00 8.54 N +ATOM 623 CA VAL A 81 -13.133 61.018 -76.798 1.00 8.61 C +ATOM 624 C VAL A 81 -11.935 60.155 -76.437 1.00 9.44 C +ATOM 625 O VAL A 81 -11.843 59.638 -75.324 1.00 10.04 O +ATOM 626 CB VAL A 81 -12.972 62.380 -76.087 1.00 8.37 C +ATOM 627 CG1 VAL A 81 -11.743 63.105 -76.607 1.00 10.35 C +ATOM 628 CG2 VAL A 81 -14.207 63.253 -76.300 1.00 9.96 C +ATOM 629 N PHE A 82 -11.014 60.021 -77.387 1.00 9.28 N +ATOM 630 CA PHE A 82 -9.686 59.466 -77.083 1.00 7.78 C +ATOM 631 C PHE A 82 -8.664 60.459 -77.627 1.00 8.93 C +ATOM 632 O PHE A 82 -9.031 61.407 -78.324 1.00 10.52 O +ATOM 633 CB PHE A 82 -9.486 58.056 -77.685 1.00 9.32 C +ATOM 634 CG PHE A 82 -9.390 58.038 -79.183 1.00 8.64 C +ATOM 635 CD1 PHE A 82 -10.548 58.001 -79.975 1.00 9.27 C +ATOM 636 CD2 PHE A 82 -8.151 58.081 -79.822 1.00 10.31 C +ATOM 637 CE1 PHE A 82 -10.469 58.011 -81.359 1.00 9.55 C +ATOM 638 CE2 PHE A 82 -8.073 58.088 -81.212 1.00 10.67 C +ATOM 639 CZ PHE A 82 -9.245 58.058 -81.982 1.00 9.52 C +ATOM 640 N ALA A 83 -7.386 60.276 -77.302 1.00 9.11 N +ATOM 641 CA ALA A 83 -6.346 61.141 -77.864 1.00 9.96 C +ATOM 642 C ALA A 83 -5.521 60.339 -78.867 1.00 10.39 C +ATOM 643 O ALA A 83 -5.198 59.174 -78.612 1.00 10.75 O +ATOM 644 CB ALA A 83 -5.460 61.717 -76.752 1.00 10.13 C +ATOM 645 N ILE A 84 -5.176 60.954 -79.997 1.00 10.79 N +ATOM 646 CA ILE A 84 -4.514 60.221 -81.084 1.00 10.97 C +ATOM 647 C ILE A 84 -3.072 59.839 -80.740 1.00 12.55 C +ATOM 648 O ILE A 84 -2.482 59.022 -81.451 1.00 13.63 O +ATOM 649 CB ILE A 84 -4.558 60.981 -82.422 1.00 12.88 C +ATOM 650 CG1 ILE A 84 -3.852 62.325 -82.319 1.00 17.60 C +ATOM 651 CG2 ILE A 84 -6.017 61.181 -82.859 1.00 14.33 C +ATOM 652 CD1 ILE A 84 -3.304 62.817 -83.644 1.00 26.05 C +ATOM 653 N ASN A 85 -2.534 60.422 -79.668 1.00 11.17 N +ATOM 654 CA ASN A 85 -1.226 60.039 -79.143 1.00 12.78 C +ATOM 655 C ASN A 85 -1.314 59.174 -77.879 1.00 12.16 C +ATOM 656 O ASN A 85 -0.369 59.125 -77.074 1.00 14.27 O +ATOM 657 CB ASN A 85 -0.400 61.298 -78.874 1.00 14.57 C +ATOM 658 CG ASN A 85 -0.931 62.100 -77.715 1.00 15.00 C +ATOM 659 OD1 ASN A 85 -2.100 61.995 -77.354 1.00 14.32 O +ATOM 660 ND2 ASN A 85 -0.063 62.910 -77.108 1.00 21.37 N +ATOM 661 N ASN A 86 -2.439 58.490 -77.676 1.00 12.05 N +ATOM 662 CA ASN A 86 -2.643 57.689 -76.477 1.00 11.89 C +ATOM 663 C ASN A 86 -3.404 56.442 -76.878 1.00 13.15 C +ATOM 664 O ASN A 86 -4.644 56.408 -76.877 1.00 12.05 O +ATOM 665 CB ASN A 86 -3.394 58.508 -75.406 1.00 12.97 C +ATOM 666 CG ASN A 86 -3.619 57.742 -74.109 1.00 15.53 C +ATOM 667 OD1 ASN A 86 -3.503 56.526 -74.051 1.00 16.36 O +ATOM 668 ND2 ASN A 86 -3.991 58.469 -73.062 1.00 21.87 N +ATOM 669 N THR A 87 -2.651 55.414 -77.264 1.00 12.11 N +ATOM 670 CA THR A 87 -3.246 54.161 -77.708 1.00 11.94 C +ATOM 671 C THR A 87 -4.178 53.554 -76.664 1.00 11.85 C +ATOM 672 O THR A 87 -5.270 53.080 -76.997 1.00 12.59 O +ATOM 673 CB THR A 87 -2.154 53.166 -78.140 1.00 14.41 C +ATOM 674 OG1 THR A 87 -1.645 53.571 -79.413 1.00 18.10 O +ATOM 675 CG2 THR A 87 -2.721 51.771 -78.255 1.00 15.39 C +ATOM 676 N LYS A 88 -3.790 53.588 -75.397 1.00 11.91 N +ATOM 677 CA LYS A 88 -4.643 53.046 -74.361 1.00 12.81 C +ATOM 678 C LYS A 88 -6.020 53.730 -74.326 1.00 12.55 C +ATOM 679 O LYS A 88 -7.029 53.071 -74.102 1.00 13.10 O +ATOM 680 CB LYS A 88 -3.955 53.148 -72.993 1.00 15.94 C +ATOM 681 CG LYS A 88 -4.691 52.466 -71.860 1.00 21.08 C +ATOM 682 CD LYS A 88 -4.957 50.999 -72.153 1.00 27.28 C +ATOM 683 CE LYS A 88 -5.505 50.307 -70.907 1.00 36.77 C +ATOM 684 NZ LYS A 88 -6.572 49.321 -71.235 1.00 41.06 N +ATOM 685 N SER A 89 -6.061 55.049 -74.535 1.00 11.62 N +ATOM 686 CA SER A 89 -7.340 55.775 -74.488 1.00 10.97 C +ATOM 687 C SER A 89 -8.276 55.314 -75.605 1.00 10.66 C +ATOM 688 O SER A 89 -9.498 55.306 -75.445 1.00 11.31 O +ATOM 689 CB SER A 89 -7.148 57.306 -74.530 1.00 10.62 C +ATOM 690 OG SER A 89 -6.702 57.770 -75.786 1.00 10.27 O +ATOM 691 N PHE A 90 -7.702 54.948 -76.746 1.00 10.82 N +ATOM 692 CA PHE A 90 -8.457 54.385 -77.867 1.00 9.94 C +ATOM 693 C PHE A 90 -8.988 52.987 -77.534 1.00 11.65 C +ATOM 694 O PHE A 90 -10.166 52.678 -77.761 1.00 13.43 O +ATOM 695 CB PHE A 90 -7.569 54.377 -79.123 1.00 11.55 C +ATOM 696 CG PHE A 90 -8.221 53.799 -80.345 1.00 10.00 C +ATOM 697 CD1 PHE A 90 -9.236 54.483 -81.014 1.00 12.00 C +ATOM 698 CD2 PHE A 90 -7.800 52.572 -80.845 1.00 12.55 C +ATOM 699 CE1 PHE A 90 -9.820 53.956 -82.144 1.00 14.02 C +ATOM 700 CE2 PHE A 90 -8.384 52.024 -81.979 1.00 14.38 C +ATOM 701 CZ PHE A 90 -9.392 52.723 -82.641 1.00 14.08 C +ATOM 702 N GLU A 91 -8.130 52.161 -76.947 1.00 11.91 N +ATOM 703 CA GLU A 91 -8.540 50.827 -76.539 1.00 13.64 C +ATOM 704 C GLU A 91 -9.631 50.893 -75.460 1.00 16.40 C +ATOM 705 O GLU A 91 -10.456 49.980 -75.354 1.00 21.99 O +ATOM 706 CB GLU A 91 -7.330 50.025 -76.054 1.00 14.68 C +ATOM 707 CG GLU A 91 -6.278 49.869 -77.141 1.00 16.13 C +ATOM 708 CD GLU A 91 -4.984 49.242 -76.659 1.00 16.54 C +ATOM 709 OE1 GLU A 91 -4.720 49.218 -75.442 1.00 17.89 O +ATOM 710 OE2 GLU A 91 -4.211 48.788 -77.533 1.00 14.41 O +ATOM 711 N ASP A 92 -9.637 51.965 -74.675 1.00 13.32 N +ATOM 712 CA ASP A 92 -10.611 52.165 -73.591 1.00 15.18 C +ATOM 713 C ASP A 92 -12.008 52.524 -74.103 1.00 15.75 C +ATOM 714 O ASP A 92 -12.979 52.461 -73.338 1.00 14.55 O +ATOM 715 CB ASP A 92 -10.194 53.330 -72.676 1.00 20.00 C +ATOM 716 CG ASP A 92 -9.007 53.010 -71.767 1.00 23.76 C +ATOM 717 OD1 ASP A 92 -8.708 51.822 -71.512 1.00 25.38 O +ATOM 718 OD2 ASP A 92 -8.373 53.982 -71.272 1.00 24.25 O +ATOM 719 N ILE A 93 -12.107 52.970 -75.352 1.00 11.94 N +ATOM 720 CA ILE A 93 -13.388 53.447 -75.875 1.00 12.89 C +ATOM 721 C ILE A 93 -14.476 52.385 -75.721 1.00 16.47 C +ATOM 722 O ILE A 93 -15.612 52.705 -75.349 1.00 16.14 O +ATOM 723 CB ILE A 93 -13.269 53.898 -77.355 1.00 11.45 C +ATOM 724 CG1 ILE A 93 -12.479 55.212 -77.452 1.00 11.86 C +ATOM 725 CG2 ILE A 93 -14.659 54.039 -78.012 1.00 14.95 C +ATOM 726 CD1 ILE A 93 -13.220 56.481 -76.947 1.00 11.56 C +ATOM 727 N HIS A 94 -14.114 51.134 -76.007 1.00 16.01 N +ATOM 728 CA HIS A 94 -15.030 50.002 -75.899 1.00 19.61 C +ATOM 729 C HIS A 94 -15.746 50.027 -74.554 1.00 17.08 C +ATOM 730 O HIS A 94 -16.968 49.886 -74.480 1.00 20.54 O +ATOM 731 CB HIS A 94 -14.234 48.700 -76.071 1.00 25.76 C +ATOM 732 CG HIS A 94 -15.050 47.451 -75.928 1.00 31.36 C +ATOM 733 ND1 HIS A 94 -14.996 46.652 -74.805 1.00 40.91 N +ATOM 734 CD2 HIS A 94 -15.922 46.852 -76.773 1.00 33.77 C +ATOM 735 CE1 HIS A 94 -15.806 45.620 -74.961 1.00 32.86 C +ATOM 736 NE2 HIS A 94 -16.382 45.718 -76.146 1.00 34.16 N +ATOM 737 N GLN A 95 -14.981 50.227 -73.488 1.00 19.42 N +ATOM 738 CA GLN A 95 -15.551 50.256 -72.149 1.00 20.18 C +ATOM 739 C GLN A 95 -16.473 51.453 -71.892 1.00 16.85 C +ATOM 740 O GLN A 95 -17.480 51.313 -71.203 1.00 19.27 O +ATOM 741 CB GLN A 95 -14.454 50.167 -71.084 1.00 26.19 C +ATOM 742 CG GLN A 95 -13.462 49.033 -71.312 1.00 32.91 C +ATOM 743 CD GLN A 95 -14.127 47.682 -71.482 1.00 40.40 C +ATOM 744 OE1 GLN A 95 -13.643 46.831 -72.234 1.00 48.01 O +ATOM 745 NE2 GLN A 95 -15.237 47.472 -70.780 1.00 43.37 N +ATOM 746 N TYR A 96 -16.151 52.628 -72.445 1.00 16.37 N +ATOM 747 CA TYR A 96 -17.067 53.764 -72.328 1.00 15.17 C +ATOM 748 C TYR A 96 -18.359 53.527 -73.095 1.00 15.31 C +ATOM 749 O TYR A 96 -19.433 53.886 -72.620 1.00 17.11 O +ATOM 750 CB TYR A 96 -16.395 55.098 -72.754 1.00 14.68 C +ATOM 751 CG TYR A 96 -15.350 55.523 -71.765 1.00 14.07 C +ATOM 752 CD1 TYR A 96 -15.693 56.209 -70.598 1.00 16.17 C +ATOM 753 CD2 TYR A 96 -14.020 55.205 -71.973 1.00 16.32 C +ATOM 754 CE1 TYR A 96 -14.720 56.558 -69.677 1.00 16.68 C +ATOM 755 CE2 TYR A 96 -13.060 55.544 -71.068 1.00 18.96 C +ATOM 756 CZ TYR A 96 -13.405 56.219 -69.930 1.00 19.36 C +ATOM 757 OH TYR A 96 -12.408 56.540 -69.033 1.00 25.67 O +ATOM 758 N ARG A 97 -18.264 52.926 -74.274 1.00 15.32 N +ATOM 759 CA ARG A 97 -19.474 52.610 -75.030 1.00 17.91 C +ATOM 760 C ARG A 97 -20.355 51.629 -74.258 1.00 19.74 C +ATOM 761 O ARG A 97 -21.575 51.797 -74.205 1.00 18.87 O +ATOM 762 CB ARG A 97 -19.146 52.053 -76.412 1.00 19.74 C +ATOM 763 CG ARG A 97 -20.399 51.726 -77.219 1.00 26.08 C +ATOM 764 CD ARG A 97 -20.066 51.449 -78.667 1.00 29.77 C +ATOM 765 NE ARG A 97 -21.259 51.269 -79.493 1.00 30.30 N +ATOM 766 CZ ARG A 97 -21.795 50.086 -79.776 1.00 37.01 C +ATOM 767 NH1 ARG A 97 -21.251 48.978 -79.291 1.00 36.00 N +ATOM 768 NH2 ARG A 97 -22.876 50.011 -80.541 1.00 37.50 N +ATOM 769 N GLU A 98 -19.737 50.613 -73.662 1.00 17.89 N +ATOM 770 CA GLU A 98 -20.490 49.656 -72.844 1.00 20.79 C +ATOM 771 C GLU A 98 -21.166 50.349 -71.666 1.00 19.29 C +ATOM 772 O GLU A 98 -22.310 50.031 -71.321 1.00 21.23 O +ATOM 773 CB GLU A 98 -19.580 48.530 -72.347 1.00 23.31 C +ATOM 774 CG GLU A 98 -19.106 47.603 -73.447 1.00 27.83 C +ATOM 775 CD GLU A 98 -20.261 47.016 -74.244 1.00 39.80 C +ATOM 776 OE1 GLU A 98 -20.243 47.114 -75.492 1.00 44.73 O +ATOM 777 OE2 GLU A 98 -21.192 46.461 -73.620 1.00 45.19 O +ATOM 778 N GLN A 99 -20.482 51.297 -71.036 1.00 16.63 N +ATOM 779 CA GLN A 99 -21.093 52.038 -69.942 1.00 18.41 C +ATOM 780 C GLN A 99 -22.274 52.879 -70.423 1.00 19.65 C +ATOM 781 O GLN A 99 -23.315 52.936 -69.770 1.00 18.90 O +ATOM 782 CB GLN A 99 -20.066 52.920 -69.232 1.00 21.51 C +ATOM 783 CG GLN A 99 -20.623 53.626 -68.016 1.00 28.72 C +ATOM 784 CD GLN A 99 -19.561 54.365 -67.236 1.00 32.94 C +ATOM 785 OE1 GLN A 99 -18.693 55.019 -67.818 1.00 32.51 O +ATOM 786 NE2 GLN A 99 -19.616 54.263 -65.910 1.00 33.09 N +ATOM 787 N ILE A 100 -22.124 53.539 -71.566 1.00 16.38 N +ATOM 788 CA ILE A 100 -23.221 54.299 -72.147 1.00 18.18 C +ATOM 789 C ILE A 100 -24.438 53.410 -72.414 1.00 17.59 C +ATOM 790 O ILE A 100 -25.566 53.787 -72.080 1.00 18.89 O +ATOM 791 CB ILE A 100 -22.774 54.998 -73.452 1.00 17.09 C +ATOM 792 CG1 ILE A 100 -21.805 56.133 -73.124 1.00 18.21 C +ATOM 793 CG2 ILE A 100 -23.972 55.546 -74.219 1.00 18.83 C +ATOM 794 CD1 ILE A 100 -20.942 56.548 -74.303 1.00 16.52 C +ATOM 795 N LYS A 101 -24.206 52.249 -73.013 1.00 18.26 N +ATOM 796 CA LYS A 101 -25.299 51.330 -73.328 1.00 21.01 C +ATOM 797 C LYS A 101 -25.987 50.920 -72.039 1.00 23.79 C +ATOM 798 O LYS A 101 -27.215 50.818 -71.977 1.00 22.54 O +ATOM 799 CB LYS A 101 -24.772 50.104 -74.075 1.00 21.60 C +ATOM 800 CG LYS A 101 -24.433 50.389 -75.539 1.00 24.96 C +ATOM 801 CD LYS A 101 -23.623 49.262 -76.168 1.00 32.12 C +ATOM 802 CE LYS A 101 -24.403 47.965 -76.206 1.00 40.80 C +ATOM 803 NZ LYS A 101 -23.577 46.865 -76.781 1.00 44.82 N +ATOM 804 N ARG A 102 -25.184 50.726 -71.002 1.00 20.61 N +ATOM 805 CA AARG A 102 -25.686 50.312 -69.699 0.53 25.51 C +ATOM 806 CA BARG A 102 -25.701 50.311 -69.706 0.47 25.50 C +ATOM 807 C ARG A 102 -26.585 51.384 -69.085 1.00 26.09 C +ATOM 808 O ARG A 102 -27.701 51.100 -68.674 1.00 27.88 O +ATOM 809 CB AARG A 102 -24.507 49.988 -68.777 0.53 28.30 C +ATOM 810 CB BARG A 102 -24.556 49.939 -68.760 0.47 28.28 C +ATOM 811 CG AARG A 102 -24.850 49.188 -67.537 0.53 32.26 C +ATOM 812 CG BARG A 102 -25.001 49.595 -67.350 0.47 32.16 C +ATOM 813 CD AARG A 102 -23.634 48.414 -67.036 0.53 32.84 C +ATOM 814 CD BARG A 102 -23.873 48.965 -66.549 0.47 32.53 C +ATOM 815 NE AARG A 102 -22.449 49.260 -66.899 0.53 33.61 N +ATOM 816 NE BARG A 102 -22.706 49.837 -66.438 0.47 32.48 N +ATOM 817 CZ AARG A 102 -21.307 49.062 -67.551 0.53 27.94 C +ATOM 818 CZ BARG A 102 -22.528 50.727 -65.468 0.47 28.84 C +ATOM 819 NH1AARG A 102 -21.184 48.039 -68.387 0.53 31.16 N +ATOM 820 NH1BARG A 102 -23.446 50.870 -64.522 0.47 33.90 N +ATOM 821 NH2AARG A 102 -20.285 49.883 -67.363 0.53 28.25 N +ATOM 822 NH2BARG A 102 -21.433 51.475 -65.443 0.47 32.29 N +ATOM 823 N VAL A 103 -26.107 52.626 -69.032 1.00 22.10 N +ATOM 824 CA VAL A 103 -26.857 53.694 -68.375 1.00 23.85 C +ATOM 825 C VAL A 103 -28.081 54.183 -69.150 1.00 25.11 C +ATOM 826 O VAL A 103 -29.011 54.740 -68.561 1.00 27.12 O +ATOM 827 CB VAL A 103 -25.951 54.887 -68.017 1.00 27.77 C +ATOM 828 CG1 VAL A 103 -24.736 54.406 -67.241 1.00 29.88 C +ATOM 829 CG2 VAL A 103 -25.519 55.619 -69.272 1.00 27.37 C +ATOM 830 N LYS A 104 -28.098 53.972 -70.461 1.00 20.37 N +ATOM 831 CA LYS A 104 -29.238 54.391 -71.264 1.00 21.20 C +ATOM 832 C LYS A 104 -30.173 53.211 -71.542 1.00 23.90 C +ATOM 833 O LYS A 104 -31.286 53.398 -72.027 1.00 25.19 O +ATOM 834 CB LYS A 104 -28.781 55.026 -72.585 1.00 18.38 C +ATOM 835 CG LYS A 104 -27.931 56.295 -72.432 1.00 19.57 C +ATOM 836 CD LYS A 104 -28.637 57.366 -71.606 1.00 21.43 C +ATOM 837 CE LYS A 104 -29.901 57.850 -72.273 1.00 21.46 C +ATOM 838 NZ LYS A 104 -30.471 59.026 -71.567 1.00 22.84 N +ATOM 839 N ASP A 105 -29.705 52.005 -71.238 1.00 24.35 N +ATOM 840 CA ASP A 105 -30.484 50.790 -71.471 1.00 24.79 C +ATOM 841 C ASP A 105 -30.912 50.713 -72.918 1.00 30.59 C +ATOM 842 O ASP A 105 -32.067 50.413 -73.225 1.00 31.30 O +ATOM 843 CB ASP A 105 -31.709 50.759 -70.566 1.00 28.69 C +ATOM 844 CG ASP A 105 -31.338 50.701 -69.119 1.00 35.28 C +ATOM 845 OD1 ASP A 105 -31.047 49.585 -68.644 1.00 42.19 O +ATOM 846 OD2 ASP A 105 -31.321 51.766 -68.462 1.00 39.42 O +ATOM 847 N SER A 106 -29.965 50.987 -73.804 1.00 23.20 N +ATOM 848 CA SER A 106 -30.221 50.995 -75.229 1.00 26.51 C +ATOM 849 C SER A 106 -28.956 50.657 -75.999 1.00 27.64 C +ATOM 850 O SER A 106 -27.849 51.006 -75.577 1.00 24.69 O +ATOM 851 CB SER A 106 -30.722 52.371 -75.658 1.00 27.52 C +ATOM 852 OG SER A 106 -30.840 52.437 -77.066 1.00 33.33 O +ATOM 853 N ASP A 107 -29.130 49.985 -77.134 1.00 30.30 N +ATOM 854 CA ASP A 107 -28.031 49.687 -78.041 1.00 30.82 C +ATOM 855 C ASP A 107 -27.985 50.733 -79.150 1.00 34.08 C +ATOM 856 O ASP A 107 -27.163 50.647 -80.062 1.00 37.02 O +ATOM 857 CB ASP A 107 -28.212 48.300 -78.658 1.00 38.11 C +ATOM 858 CG ASP A 107 -28.460 47.227 -77.615 1.00 47.48 C +ATOM 859 OD1 ASP A 107 -27.477 46.718 -77.035 1.00 48.97 O +ATOM 860 OD2 ASP A 107 -29.640 46.893 -77.377 1.00 52.49 O +ATOM 861 N ASP A 108 -28.879 51.713 -79.055 1.00 26.77 N +ATOM 862 CA ASP A 108 -29.045 52.741 -80.080 1.00 28.12 C +ATOM 863 C ASP A 108 -28.992 54.134 -79.455 1.00 26.18 C +ATOM 864 O ASP A 108 -30.017 54.801 -79.320 1.00 31.53 O +ATOM 865 CB ASP A 108 -30.388 52.554 -80.794 1.00 37.49 C +ATOM 866 CG ASP A 108 -30.542 53.461 -82.004 1.00 40.00 C +ATOM 867 OD1 ASP A 108 -29.528 53.735 -82.679 1.00 38.22 O +ATOM 868 OD2 ASP A 108 -31.681 53.898 -82.283 1.00 43.30 O +ATOM 869 N VAL A 109 -27.797 54.562 -79.061 1.00 20.57 N +ATOM 870 CA VAL A 109 -27.618 55.860 -78.414 1.00 17.73 C +ATOM 871 C VAL A 109 -26.816 56.782 -79.329 1.00 15.41 C +ATOM 872 O VAL A 109 -25.799 56.367 -79.870 1.00 16.42 O +ATOM 873 CB VAL A 109 -26.847 55.710 -77.094 1.00 16.64 C +ATOM 874 CG1 VAL A 109 -26.722 57.044 -76.383 1.00 17.73 C +ATOM 875 CG2 VAL A 109 -27.539 54.697 -76.195 1.00 20.11 C +ATOM 876 N PRO A 110 -27.266 58.033 -79.503 1.00 11.95 N +ATOM 877 CA PRO A 110 -26.483 58.946 -80.352 1.00 12.38 C +ATOM 878 C PRO A 110 -25.077 59.167 -79.797 1.00 12.68 C +ATOM 879 O PRO A 110 -24.903 59.494 -78.609 1.00 12.03 O +ATOM 880 CB PRO A 110 -27.273 60.253 -80.290 1.00 13.50 C +ATOM 881 CG PRO A 110 -28.692 59.811 -80.029 1.00 15.24 C +ATOM 882 CD PRO A 110 -28.519 58.664 -79.053 1.00 13.89 C +ATOM 883 N MET A 111 -24.080 59.010 -80.666 1.00 11.84 N +ATOM 884 CA MET A 111 -22.678 59.073 -80.249 1.00 12.30 C +ATOM 885 C MET A 111 -21.831 59.538 -81.416 1.00 11.07 C +ATOM 886 O MET A 111 -22.172 59.290 -82.569 1.00 12.50 O +ATOM 887 CB MET A 111 -22.177 57.678 -79.849 1.00 16.68 C +ATOM 888 CG MET A 111 -22.705 57.091 -78.558 1.00 18.18 C +ATOM 889 SD MET A 111 -21.830 55.549 -78.180 1.00 25.84 S +ATOM 890 CE MET A 111 -20.255 55.867 -78.940 1.00 33.11 C +ATOM 891 N VAL A 112 -20.705 60.170 -81.102 1.00 9.25 N +ATOM 892 CA VAL A 112 -19.676 60.501 -82.075 1.00 9.98 C +ATOM 893 C VAL A 112 -18.347 60.081 -81.457 1.00 10.05 C +ATOM 894 O VAL A 112 -18.111 60.340 -80.275 1.00 10.45 O +ATOM 895 CB VAL A 112 -19.669 62.028 -82.370 1.00 9.57 C +ATOM 896 CG1 VAL A 112 -18.481 62.431 -83.233 1.00 11.31 C +ATOM 897 CG2 VAL A 112 -20.984 62.426 -83.061 1.00 10.44 C +ATOM 898 N LEU A 113 -17.489 59.443 -82.251 1.00 9.36 N +ATOM 899 CA LEU A 113 -16.129 59.102 -81.808 1.00 9.02 C +ATOM 900 C LEU A 113 -15.209 60.271 -82.163 1.00 8.77 C +ATOM 901 O LEU A 113 -15.183 60.729 -83.303 1.00 10.06 O +ATOM 902 CB LEU A 113 -15.658 57.833 -82.511 1.00 9.60 C +ATOM 903 CG LEU A 113 -14.273 57.323 -82.083 1.00 10.14 C +ATOM 904 CD1 LEU A 113 -14.334 56.855 -80.645 1.00 12.16 C +ATOM 905 CD2 LEU A 113 -13.795 56.199 -83.031 1.00 12.35 C +ATOM 906 N VAL A 114 -14.457 60.752 -81.172 1.00 8.67 N +ATOM 907 CA VAL A 114 -13.604 61.920 -81.359 1.00 9.08 C +ATOM 908 C VAL A 114 -12.163 61.561 -81.054 1.00 8.37 C +ATOM 909 O VAL A 114 -11.855 61.085 -79.965 1.00 9.46 O +ATOM 910 CB VAL A 114 -14.023 63.064 -80.415 1.00 8.72 C +ATOM 911 CG1 VAL A 114 -13.055 64.252 -80.539 1.00 11.60 C +ATOM 912 CG2 VAL A 114 -15.443 63.505 -80.756 1.00 10.39 C +ATOM 913 N GLY A 115 -11.281 61.798 -82.021 1.00 9.17 N +ATOM 914 CA GLY A 115 -9.840 61.639 -81.832 1.00 9.56 C +ATOM 915 C GLY A 115 -9.227 63.013 -81.631 1.00 9.51 C +ATOM 916 O GLY A 115 -9.072 63.783 -82.585 1.00 10.94 O +ATOM 917 N ASN A 116 -8.888 63.328 -80.384 1.00 9.08 N +ATOM 918 CA ASN A 116 -8.434 64.664 -80.037 1.00 10.09 C +ATOM 919 C ASN A 116 -6.899 64.748 -80.043 1.00 10.56 C +ATOM 920 O ASN A 116 -6.207 63.731 -80.130 1.00 10.76 O +ATOM 921 CB ASN A 116 -9.011 65.066 -78.673 1.00 9.93 C +ATOM 922 CG ASN A 116 -8.763 66.529 -78.334 1.00 9.76 C +ATOM 923 OD1 ASN A 116 -8.973 67.410 -79.165 1.00 11.19 O +ATOM 924 ND2 ASN A 116 -8.303 66.785 -77.117 1.00 10.27 N +ATOM 925 N LYS A 117 -6.400 65.979 -79.959 1.00 11.42 N +ATOM 926 CA LYS A 117 -4.971 66.309 -79.979 1.00 10.46 C +ATOM 927 C LYS A 117 -4.351 66.108 -81.356 1.00 14.83 C +ATOM 928 O LYS A 117 -3.188 65.758 -81.471 1.00 15.26 O +ATOM 929 CB LYS A 117 -4.178 65.573 -78.898 1.00 12.21 C +ATOM 930 CG LYS A 117 -4.803 65.671 -77.518 1.00 11.11 C +ATOM 931 CD LYS A 117 -3.786 65.362 -76.426 1.00 12.36 C +ATOM 932 CE LYS A 117 -4.455 65.352 -75.061 1.00 11.54 C +ATOM 933 NZ LYS A 117 -3.495 65.057 -73.965 1.00 14.14 N +ATOM 934 N CYS A 118 -5.125 66.374 -82.404 1.00 12.96 N +ATOM 935 CA CYS A 118 -4.640 66.125 -83.764 1.00 15.85 C +ATOM 936 C CYS A 118 -3.580 67.129 -84.209 1.00 17.62 C +ATOM 937 O CYS A 118 -3.002 66.984 -85.285 1.00 21.19 O +ATOM 938 CB CYS A 118 -5.805 66.054 -84.767 1.00 17.20 C +ATOM 939 SG CYS A 118 -6.660 67.625 -85.093 1.00 19.52 S +ATOM 940 N ASP A 119 -3.308 68.126 -83.371 1.00 15.05 N +ATOM 941 CA ASP A 119 -2.200 69.056 -83.591 1.00 17.01 C +ATOM 942 C ASP A 119 -0.838 68.457 -83.230 1.00 20.14 C +ATOM 943 O ASP A 119 0.206 69.017 -83.605 1.00 21.12 O +ATOM 944 CB ASP A 119 -2.433 70.325 -82.783 1.00 15.82 C +ATOM 945 CG ASP A 119 -2.542 70.051 -81.293 1.00 17.48 C +ATOM 946 OD1 ASP A 119 -3.618 69.562 -80.850 1.00 14.95 O +ATOM 947 OD2 ASP A 119 -1.557 70.309 -80.567 1.00 17.84 O +ATOM 948 N LEU A 120 -0.844 67.338 -82.504 1.00 17.56 N +ATOM 949 CA LEU A 120 0.392 66.678 -82.056 1.00 18.44 C +ATOM 950 C LEU A 120 0.855 65.626 -83.052 1.00 20.86 C +ATOM 951 O LEU A 120 0.048 65.021 -83.749 1.00 23.33 O +ATOM 952 CB LEU A 120 0.189 66.030 -80.682 1.00 19.73 C +ATOM 953 CG LEU A 120 -0.126 66.979 -79.524 1.00 20.87 C +ATOM 954 CD1 LEU A 120 -0.341 66.208 -78.224 1.00 22.37 C +ATOM 955 CD2 LEU A 120 0.964 68.021 -79.348 1.00 23.95 C +ATOM 956 N ALA A 121 2.165 65.382 -83.103 1.00 23.43 N +ATOM 957 CA ALA A 121 2.711 64.492 -84.128 1.00 25.46 C +ATOM 958 C ALA A 121 3.089 63.086 -83.656 1.00 23.72 C +ATOM 959 O ALA A 121 3.434 62.238 -84.475 1.00 23.14 O +ATOM 960 CB ALA A 121 3.895 65.151 -84.838 1.00 26.56 C +ATOM 961 N ALA A 122 3.011 62.825 -82.353 1.00 22.58 N +ATOM 962 CA ALA A 122 3.297 61.491 -81.833 1.00 23.25 C +ATOM 963 C ALA A 122 2.069 60.605 -81.955 1.00 22.64 C +ATOM 964 O ALA A 122 1.615 59.980 -80.983 1.00 21.44 O +ATOM 965 CB ALA A 122 3.777 61.549 -80.394 1.00 25.58 C +ATOM 966 N ARG A 123 1.534 60.557 -83.167 1.00 18.28 N +ATOM 967 CA ARG A 123 0.324 59.813 -83.420 1.00 18.45 C +ATOM 968 C ARG A 123 0.608 58.325 -83.320 1.00 20.43 C +ATOM 969 O ARG A 123 1.553 57.818 -83.933 1.00 20.54 O +ATOM 970 CB ARG A 123 -0.206 60.157 -84.808 1.00 20.10 C +ATOM 971 CG ARG A 123 -1.443 59.379 -85.184 1.00 20.07 C +ATOM 972 CD ARG A 123 -1.877 59.684 -86.609 1.00 22.34 C +ATOM 973 NE ARG A 123 -2.452 61.015 -86.755 1.00 23.44 N +ATOM 974 CZ ARG A 123 -3.760 61.260 -86.713 1.00 21.43 C +ATOM 975 NH1 ARG A 123 -4.210 62.497 -86.874 1.00 22.61 N +ATOM 976 NH2 ARG A 123 -4.603 60.259 -86.493 1.00 17.00 N +ATOM 977 N THR A 124 -0.188 57.628 -82.521 1.00 14.26 N +ATOM 978 CA THR A 124 -0.136 56.182 -82.458 1.00 14.31 C +ATOM 979 C THR A 124 -1.452 55.533 -82.888 1.00 16.34 C +ATOM 980 O THR A 124 -1.515 54.327 -83.088 1.00 18.42 O +ATOM 981 CB THR A 124 0.273 55.676 -81.060 1.00 14.96 C +ATOM 982 OG1 THR A 124 -0.645 56.192 -80.089 1.00 15.78 O +ATOM 983 CG2 THR A 124 1.721 56.117 -80.710 1.00 15.82 C +ATOM 984 N VAL A 125 -2.494 56.356 -83.038 1.00 15.62 N +ATOM 985 CA VAL A 125 -3.762 55.890 -83.609 1.00 15.91 C +ATOM 986 C VAL A 125 -3.977 56.543 -84.974 1.00 11.30 C +ATOM 987 O VAL A 125 -4.122 57.750 -85.080 1.00 17.30 O +ATOM 988 CB VAL A 125 -4.963 56.216 -82.686 1.00 14.86 C +ATOM 989 CG1 VAL A 125 -6.238 55.579 -83.249 1.00 15.44 C +ATOM 990 CG2 VAL A 125 -4.709 55.728 -81.249 1.00 16.32 C +ATOM 991 N GLU A 126 -3.921 55.727 -86.022 1.00 20.05 N +ATOM 992 CA GLU A 126 -4.073 56.251 -87.374 1.00 19.94 C +ATOM 993 C GLU A 126 -5.553 56.454 -87.677 1.00 15.81 C +ATOM 994 O GLU A 126 -6.403 55.745 -87.145 1.00 18.08 O +ATOM 995 CB GLU A 126 -3.417 55.322 -88.395 1.00 24.12 C +ATOM 996 CG GLU A 126 -1.884 55.247 -88.259 1.00 24.95 C +ATOM 997 CD GLU A 126 -1.182 56.562 -88.593 1.00 32.21 C +ATOM 998 OE1 GLU A 126 -0.175 56.896 -87.930 1.00 31.69 O +ATOM 999 OE2 GLU A 126 -1.628 57.263 -89.527 1.00 43.66 O +ATOM 1000 N SER A 127 -5.836 57.443 -88.508 1.00 20.48 N +ATOM 1001 CA SER A 127 -7.207 57.773 -88.846 1.00 17.68 C +ATOM 1002 C SER A 127 -8.026 56.542 -89.247 1.00 19.24 C +ATOM 1003 O SER A 127 -9.142 56.347 -88.754 1.00 16.43 O +ATOM 1004 CB SER A 127 -7.247 58.811 -89.958 1.00 24.87 C +ATOM 1005 OG SER A 127 -8.582 59.234 -90.166 1.00 20.65 O +ATOM 1006 N ARG A 128 -7.483 55.719 -90.141 1.00 18.05 N +ATOM 1007 CA ARG A 128 -8.220 54.559 -90.635 1.00 19.97 C +ATOM 1008 C ARG A 128 -8.634 53.594 -89.525 1.00 16.75 C +ATOM 1009 O ARG A 128 -9.714 53.008 -89.572 1.00 19.28 O +ATOM 1010 CB ARG A 128 -7.423 53.830 -91.718 1.00 22.74 C +ATOM 1011 N GLN A 129 -7.790 53.440 -88.506 1.00 17.01 N +ATOM 1012 CA AGLN A 129 -8.116 52.551 -87.395 0.50 17.43 C +ATOM 1013 CA BGLN A 129 -8.100 52.562 -87.385 0.50 17.44 C +ATOM 1014 C GLN A 129 -9.329 53.053 -86.617 1.00 15.16 C +ATOM 1015 O GLN A 129 -10.192 52.276 -86.229 1.00 15.97 O +ATOM 1016 CB AGLN A 129 -6.915 52.365 -86.451 0.50 22.56 C +ATOM 1017 CB BGLN A 129 -6.892 52.470 -86.441 0.50 22.49 C +ATOM 1018 CG AGLN A 129 -5.995 51.198 -86.830 0.50 22.85 C +ATOM 1019 CG BGLN A 129 -5.598 52.025 -87.129 0.50 23.66 C +ATOM 1020 CD AGLN A 129 -4.905 50.916 -85.798 0.50 26.09 C +ATOM 1021 CD BGLN A 129 -4.419 51.900 -86.170 0.50 23.68 C +ATOM 1022 OE1AGLN A 129 -4.762 51.633 -84.800 0.50 21.16 O +ATOM 1023 OE1BGLN A 129 -3.892 52.897 -85.673 0.50 19.43 O +ATOM 1024 NE2AGLN A 129 -4.128 49.860 -86.040 0.50 26.73 N +ATOM 1025 NE2BGLN A 129 -3.999 50.667 -85.914 0.50 27.88 N +ATOM 1026 N ALA A 130 -9.384 54.365 -86.403 1.00 14.60 N +ATOM 1027 CA ALA A 130 -10.510 54.963 -85.695 1.00 13.94 C +ATOM 1028 C ALA A 130 -11.779 54.968 -86.548 1.00 13.71 C +ATOM 1029 O ALA A 130 -12.885 54.771 -86.027 1.00 13.27 O +ATOM 1030 CB ALA A 130 -10.150 56.369 -85.263 1.00 14.56 C +ATOM 1031 N GLN A 131 -11.613 55.220 -87.845 1.00 13.58 N +ATOM 1032 CA GLN A 131 -12.745 55.159 -88.769 1.00 13.81 C +ATOM 1033 C GLN A 131 -13.387 53.789 -88.706 1.00 16.06 C +ATOM 1034 O GLN A 131 -14.617 53.671 -88.715 1.00 16.79 O +ATOM 1035 CB GLN A 131 -12.301 55.441 -90.201 1.00 13.12 C +ATOM 1036 CG GLN A 131 -11.767 56.846 -90.470 1.00 14.55 C +ATOM 1037 CD GLN A 131 -11.230 56.969 -91.885 1.00 18.59 C +ATOM 1038 OE1 GLN A 131 -11.715 56.293 -92.801 1.00 18.52 O +ATOM 1039 NE2 GLN A 131 -10.217 57.806 -92.068 1.00 18.11 N +ATOM 1040 N ASP A 132 -12.559 52.747 -88.626 1.00 15.51 N +ATOM 1041 CA ASP A 132 -13.061 51.372 -88.566 1.00 14.97 C +ATOM 1042 C ASP A 132 -13.825 51.094 -87.280 1.00 14.43 C +ATOM 1043 O ASP A 132 -14.856 50.421 -87.285 1.00 16.93 O +ATOM 1044 CB ASP A 132 -11.915 50.357 -88.678 1.00 19.37 C +ATOM 1045 CG ASP A 132 -11.365 50.242 -90.082 1.00 28.25 C +ATOM 1046 OD1 ASP A 132 -12.020 50.735 -91.021 1.00 29.55 O +ATOM 1047 OD2 ASP A 132 -10.272 49.647 -90.238 1.00 29.11 O +ATOM 1048 N LEU A 133 -13.326 51.615 -86.162 1.00 14.35 N +ATOM 1049 CA LEU A 133 -14.030 51.441 -84.906 1.00 13.78 C +ATOM 1050 C LEU A 133 -15.396 52.127 -84.971 1.00 15.44 C +ATOM 1051 O LEU A 133 -16.408 51.540 -84.615 1.00 15.11 O +ATOM 1052 CB LEU A 133 -13.215 52.009 -83.744 1.00 14.63 C +ATOM 1053 CG LEU A 133 -13.887 51.910 -82.379 1.00 15.51 C +ATOM 1054 CD1 LEU A 133 -14.218 50.472 -82.017 1.00 19.49 C +ATOM 1055 CD2 LEU A 133 -12.998 52.550 -81.306 1.00 16.67 C +ATOM 1056 N ALA A 134 -15.402 53.371 -85.433 1.00 13.37 N +ATOM 1057 CA ALA A 134 -16.644 54.118 -85.523 1.00 12.93 C +ATOM 1058 C ALA A 134 -17.628 53.418 -86.462 1.00 15.44 C +ATOM 1059 O ALA A 134 -18.817 53.338 -86.156 1.00 14.32 O +ATOM 1060 CB ALA A 134 -16.366 55.538 -85.975 1.00 12.41 C +ATOM 1061 N ARG A 135 -17.136 52.909 -87.589 1.00 14.99 N +ATOM 1062 CA ARG A 135 -17.994 52.166 -88.512 1.00 15.20 C +ATOM 1063 C ARG A 135 -18.661 50.962 -87.834 1.00 18.59 C +ATOM 1064 O ARG A 135 -19.848 50.686 -88.056 1.00 18.85 O +ATOM 1065 CB ARG A 135 -17.194 51.717 -89.733 1.00 17.98 C +ATOM 1066 CG ARG A 135 -17.981 50.881 -90.724 1.00 19.64 C +ATOM 1067 CD ARG A 135 -17.094 50.505 -91.899 1.00 23.73 C +ATOM 1068 NE ARG A 135 -17.836 49.787 -92.930 1.00 33.90 N +ATOM 1069 CZ ARG A 135 -18.011 48.469 -92.943 1.00 43.36 C +ATOM 1070 NH1 ARG A 135 -17.495 47.718 -91.977 1.00 41.91 N +ATOM 1071 NH2 ARG A 135 -18.702 47.903 -93.923 1.00 40.26 N +ATOM 1072 N SER A 136 -17.914 50.257 -86.991 1.00 17.12 N +ATOM 1073 CA SER A 136 -18.475 49.104 -86.291 1.00 18.31 C +ATOM 1074 C SER A 136 -19.590 49.508 -85.329 1.00 20.82 C +ATOM 1075 O SER A 136 -20.467 48.706 -85.008 1.00 23.80 O +ATOM 1076 CB SER A 136 -17.379 48.324 -85.551 1.00 20.31 C +ATOM 1077 OG SER A 136 -17.059 48.923 -84.303 1.00 24.82 O +ATOM 1078 N TYR A 137 -19.555 50.758 -84.864 1.00 16.47 N +ATOM 1079 CA TYR A 137 -20.565 51.262 -83.935 1.00 16.85 C +ATOM 1080 C TYR A 137 -21.700 51.968 -84.679 1.00 16.79 C +ATOM 1081 O TYR A 137 -22.715 52.334 -84.076 1.00 21.46 O +ATOM 1082 CB TYR A 137 -19.943 52.242 -82.927 1.00 19.74 C +ATOM 1083 CG TYR A 137 -18.941 51.663 -81.944 1.00 18.29 C +ATOM 1084 CD1 TYR A 137 -18.854 50.294 -81.698 1.00 20.96 C +ATOM 1085 CD2 TYR A 137 -18.077 52.505 -81.245 1.00 20.93 C +ATOM 1086 CE1 TYR A 137 -17.927 49.781 -80.792 1.00 22.87 C +ATOM 1087 CE2 TYR A 137 -17.156 52.001 -80.341 1.00 19.31 C +ATOM 1088 CZ TYR A 137 -17.082 50.645 -80.115 1.00 21.57 C +ATOM 1089 OH TYR A 137 -16.158 50.172 -79.209 1.00 24.70 O +ATOM 1090 N GLY A 138 -21.508 52.199 -85.974 1.00 14.94 N +ATOM 1091 CA GLY A 138 -22.476 52.937 -86.768 1.00 17.22 C +ATOM 1092 C GLY A 138 -22.512 54.436 -86.487 1.00 16.46 C +ATOM 1093 O GLY A 138 -23.565 55.063 -86.589 1.00 17.67 O +ATOM 1094 N ILE A 139 -21.351 55.015 -86.170 1.00 13.92 N +ATOM 1095 CA ILE A 139 -21.254 56.425 -85.800 1.00 14.41 C +ATOM 1096 C ILE A 139 -20.124 57.101 -86.566 1.00 14.15 C +ATOM 1097 O ILE A 139 -19.237 56.438 -87.099 1.00 13.26 O +ATOM 1098 CB ILE A 139 -21.030 56.603 -84.276 1.00 12.61 C +ATOM 1099 CG1 ILE A 139 -19.634 56.113 -83.847 1.00 13.79 C +ATOM 1100 CG2 ILE A 139 -22.126 55.886 -83.494 1.00 17.47 C +ATOM 1101 CD1 ILE A 139 -19.410 56.174 -82.329 1.00 15.75 C +ATOM 1102 N PRO A 140 -20.145 58.434 -86.630 1.00 11.91 N +ATOM 1103 CA PRO A 140 -19.065 59.191 -87.272 1.00 12.26 C +ATOM 1104 C PRO A 140 -17.797 59.234 -86.422 1.00 11.67 C +ATOM 1105 O PRO A 140 -17.860 59.169 -85.196 1.00 11.75 O +ATOM 1106 CB PRO A 140 -19.632 60.614 -87.393 1.00 13.84 C +ATOM 1107 CG PRO A 140 -21.084 60.502 -87.043 1.00 16.45 C +ATOM 1108 CD PRO A 140 -21.278 59.286 -86.225 1.00 13.48 C +ATOM 1109 N TYR A 141 -16.665 59.358 -87.107 1.00 10.34 N +ATOM 1110 CA TYR A 141 -15.377 59.653 -86.478 1.00 9.81 C +ATOM 1111 C TYR A 141 -14.925 61.040 -86.907 1.00 10.33 C +ATOM 1112 O TYR A 141 -14.891 61.353 -88.101 1.00 11.52 O +ATOM 1113 CB TYR A 141 -14.320 58.635 -86.909 1.00 10.64 C +ATOM 1114 CG TYR A 141 -12.924 58.988 -86.435 1.00 11.26 C +ATOM 1115 CD1 TYR A 141 -12.656 59.173 -85.078 1.00 10.42 C +ATOM 1116 CD2 TYR A 141 -11.873 59.144 -87.337 1.00 11.74 C +ATOM 1117 CE1 TYR A 141 -11.389 59.483 -84.635 1.00 11.68 C +ATOM 1118 CE2 TYR A 141 -10.584 59.468 -86.888 1.00 12.81 C +ATOM 1119 CZ TYR A 141 -10.366 59.636 -85.539 1.00 12.20 C +ATOM 1120 OH TYR A 141 -9.095 59.918 -85.060 1.00 13.19 O +ATOM 1121 N ILE A 142 -14.556 61.873 -85.942 1.00 9.33 N +ATOM 1122 CA ILE A 142 -14.073 63.212 -86.247 1.00 11.45 C +ATOM 1123 C ILE A 142 -12.803 63.466 -85.449 1.00 10.86 C +ATOM 1124 O ILE A 142 -12.747 63.153 -84.257 1.00 11.42 O +ATOM 1125 CB ILE A 142 -15.136 64.274 -85.882 1.00 11.94 C +ATOM 1126 CG1 ILE A 142 -16.413 64.053 -86.703 1.00 16.09 C +ATOM 1127 CG2 ILE A 142 -14.602 65.684 -86.127 1.00 15.06 C +ATOM 1128 CD1 ILE A 142 -17.600 64.903 -86.272 1.00 18.24 C +ATOM 1129 N GLU A 143 -11.799 64.043 -86.097 1.00 10.55 N +ATOM 1130 CA GLU A 143 -10.597 64.461 -85.365 1.00 11.92 C +ATOM 1131 C GLU A 143 -10.641 65.916 -84.952 1.00 12.80 C +ATOM 1132 O GLU A 143 -11.148 66.771 -85.672 1.00 13.61 O +ATOM 1133 CB GLU A 143 -9.329 64.165 -86.159 1.00 12.42 C +ATOM 1134 CG GLU A 143 -9.057 62.687 -86.206 1.00 14.51 C +ATOM 1135 CD GLU A 143 -7.658 62.329 -86.655 1.00 16.79 C +ATOM 1136 OE1 GLU A 143 -6.890 63.234 -87.067 1.00 18.37 O +ATOM 1137 OE2 GLU A 143 -7.356 61.131 -86.591 1.00 14.67 O +ATOM 1138 N THR A 144 -10.117 66.192 -83.770 1.00 10.27 N +ATOM 1139 CA THR A 144 -10.178 67.529 -83.211 1.00 11.03 C +ATOM 1140 C THR A 144 -8.846 67.933 -82.611 1.00 10.66 C +ATOM 1141 O THR A 144 -8.026 67.094 -82.244 1.00 11.62 O +ATOM 1142 CB THR A 144 -11.241 67.620 -82.088 1.00 11.13 C +ATOM 1143 OG1 THR A 144 -10.895 66.710 -81.038 1.00 11.34 O +ATOM 1144 CG2 THR A 144 -12.621 67.270 -82.619 1.00 12.64 C +ATOM 1145 N SER A 145 -8.681 69.244 -82.480 1.00 11.28 N +ATOM 1146 CA SER A 145 -7.684 69.808 -81.591 1.00 11.32 C +ATOM 1147 C SER A 145 -8.311 70.904 -80.762 1.00 11.69 C +ATOM 1148 O SER A 145 -8.730 71.935 -81.292 1.00 12.91 O +ATOM 1149 CB SER A 145 -6.506 70.392 -82.371 1.00 13.60 C +ATOM 1150 OG SER A 145 -5.680 71.164 -81.504 1.00 13.30 O +ATOM 1151 N ALA A 146 -8.360 70.707 -79.452 1.00 12.45 N +ATOM 1152 CA ALA A 146 -8.798 71.774 -78.573 1.00 12.34 C +ATOM 1153 C ALA A 146 -7.834 72.960 -78.599 1.00 11.59 C +ATOM 1154 O ALA A 146 -8.221 74.075 -78.240 1.00 15.47 O +ATOM 1155 CB ALA A 146 -8.948 71.258 -77.163 1.00 13.35 C +ATOM 1156 N LYS A 147 -6.587 72.719 -79.002 1.00 13.35 N +ATOM 1157 CA LYS A 147 -5.584 73.781 -79.037 1.00 13.91 C +ATOM 1158 C LYS A 147 -5.779 74.729 -80.229 1.00 16.45 C +ATOM 1159 O LYS A 147 -5.754 75.949 -80.061 1.00 19.08 O +ATOM 1160 CB LYS A 147 -4.183 73.184 -79.036 1.00 15.15 C +ATOM 1161 CG LYS A 147 -3.104 74.252 -78.991 1.00 16.56 C +ATOM 1162 CD LYS A 147 -1.756 73.600 -78.833 1.00 22.96 C +ATOM 1163 CE LYS A 147 -0.648 74.645 -78.825 1.00 31.75 C +ATOM 1164 NZ LYS A 147 0.687 74.005 -78.697 1.00 37.60 N +ATOM 1165 N THR A 148 -6.007 74.174 -81.419 1.00 14.46 N +ATOM 1166 CA THR A 148 -6.128 74.999 -82.624 1.00 16.36 C +ATOM 1167 C THR A 148 -7.571 75.271 -83.022 1.00 16.44 C +ATOM 1168 O THR A 148 -7.827 76.080 -83.918 1.00 18.94 O +ATOM 1169 CB THR A 148 -5.457 74.327 -83.827 1.00 16.67 C +ATOM 1170 OG1 THR A 148 -6.222 73.164 -84.194 1.00 15.30 O +ATOM 1171 CG2 THR A 148 -4.022 73.923 -83.501 1.00 17.03 C +ATOM 1172 N ARG A 149 -8.503 74.586 -82.359 1.00 14.87 N +ATOM 1173 CA ARG A 149 -9.940 74.616 -82.663 1.00 13.62 C +ATOM 1174 C ARG A 149 -10.357 73.737 -83.832 1.00 13.73 C +ATOM 1175 O ARG A 149 -11.544 73.630 -84.132 1.00 14.38 O +ATOM 1176 CB ARG A 149 -10.465 76.039 -82.878 1.00 17.21 C +ATOM 1177 CG ARG A 149 -10.519 76.841 -81.623 1.00 20.85 C +ATOM 1178 CD ARG A 149 -11.240 78.173 -81.838 1.00 25.18 C +ATOM 1179 NE ARG A 149 -12.599 78.005 -82.361 1.00 24.79 N +ATOM 1180 CZ ARG A 149 -13.686 77.833 -81.612 1.00 25.46 C +ATOM 1181 NH1 ARG A 149 -13.592 77.777 -80.290 1.00 20.49 N +ATOM 1182 NH2 ARG A 149 -14.869 77.697 -82.187 1.00 25.93 N +ATOM 1183 N GLN A 150 -9.404 73.092 -84.485 1.00 12.89 N +ATOM 1184 CA GLN A 150 -9.749 72.225 -85.596 1.00 13.57 C +ATOM 1185 C GLN A 150 -10.799 71.196 -85.166 1.00 13.25 C +ATOM 1186 O GLN A 150 -10.619 70.502 -84.171 1.00 13.70 O +ATOM 1187 CB GLN A 150 -8.497 71.526 -86.131 1.00 18.23 C +ATOM 1188 CG GLN A 150 -8.777 70.630 -87.311 1.00 23.20 C +ATOM 1189 CD GLN A 150 -7.520 70.262 -88.071 1.00 29.67 C +ATOM 1190 OE1 GLN A 150 -6.438 70.144 -87.492 1.00 33.49 O +ATOM 1191 NE2 GLN A 150 -7.655 70.088 -89.381 1.00 37.58 N +ATOM 1192 N GLY A 151 -11.902 71.133 -85.908 1.00 13.76 N +ATOM 1193 CA GLY A 151 -12.904 70.098 -85.712 1.00 13.58 C +ATOM 1194 C GLY A 151 -13.799 70.250 -84.495 1.00 12.54 C +ATOM 1195 O GLY A 151 -14.730 69.452 -84.328 1.00 12.79 O +ATOM 1196 N VAL A 152 -13.528 71.230 -83.637 1.00 12.02 N +ATOM 1197 CA VAL A 152 -14.240 71.316 -82.365 1.00 11.84 C +ATOM 1198 C VAL A 152 -15.747 71.577 -82.547 1.00 12.30 C +ATOM 1199 O VAL A 152 -16.596 70.831 -82.030 1.00 12.83 O +ATOM 1200 CB VAL A 152 -13.634 72.365 -81.447 1.00 12.84 C +ATOM 1201 CG1 VAL A 152 -14.457 72.462 -80.157 1.00 15.97 C +ATOM 1202 CG2 VAL A 152 -12.184 72.015 -81.146 1.00 12.97 C +ATOM 1203 N GLU A 153 -16.102 72.631 -83.265 1.00 13.22 N +ATOM 1204 CA GLU A 153 -17.518 72.865 -83.547 1.00 13.50 C +ATOM 1205 C GLU A 153 -18.123 71.685 -84.310 1.00 15.10 C +ATOM 1206 O GLU A 153 -19.237 71.238 -84.001 1.00 13.79 O +ATOM 1207 CB GLU A 153 -17.712 74.171 -84.324 1.00 18.42 C +ATOM 1208 CG GLU A 153 -17.459 75.402 -83.494 1.00 23.44 C +ATOM 1209 CD GLU A 153 -17.943 76.673 -84.173 1.00 34.26 C +ATOM 1210 OE1 GLU A 153 -17.348 77.742 -83.922 1.00 38.94 O +ATOM 1211 OE2 GLU A 153 -18.920 76.597 -84.952 1.00 37.46 O +ATOM 1212 N ASP A 154 -17.390 71.156 -85.285 1.00 13.03 N +ATOM 1213 CA AASP A 154 -17.838 70.018 -86.088 0.47 14.51 C +ATOM 1214 CA BASP A 154 -17.894 70.055 -86.083 0.53 14.47 C +ATOM 1215 C ASP A 154 -18.244 68.866 -85.193 1.00 14.33 C +ATOM 1216 O ASP A 154 -19.268 68.222 -85.400 1.00 13.42 O +ATOM 1217 CB AASP A 154 -16.711 69.511 -87.002 0.47 20.09 C +ATOM 1218 CB BASP A 154 -16.868 69.646 -87.143 0.53 19.72 C +ATOM 1219 CG AASP A 154 -16.590 70.294 -88.292 0.47 24.68 C +ATOM 1220 CG BASP A 154 -17.499 68.959 -88.327 0.53 22.05 C +ATOM 1221 OD1AASP A 154 -16.973 71.477 -88.317 0.47 24.32 O +ATOM 1222 OD1BASP A 154 -18.715 68.679 -88.276 0.53 25.33 O +ATOM 1223 OD2AASP A 154 -16.100 69.707 -89.284 0.47 26.92 O +ATOM 1224 OD2BASP A 154 -16.772 68.701 -89.312 0.53 25.98 O +ATOM 1225 N ALA A 155 -17.412 68.574 -84.204 1.00 12.58 N +ATOM 1226 CA ALA A 155 -17.662 67.409 -83.362 1.00 12.13 C +ATOM 1227 C ALA A 155 -18.937 67.569 -82.560 1.00 10.77 C +ATOM 1228 O ALA A 155 -19.780 66.679 -82.532 1.00 11.34 O +ATOM 1229 CB ALA A 155 -16.481 67.154 -82.433 1.00 13.14 C +ATOM 1230 N PHE A 156 -19.069 68.703 -81.891 1.00 9.87 N +ATOM 1231 CA PHE A 156 -20.253 68.935 -81.089 1.00 11.17 C +ATOM 1232 C PHE A 156 -21.514 69.082 -81.946 1.00 11.91 C +ATOM 1233 O PHE A 156 -22.565 68.539 -81.596 1.00 12.48 O +ATOM 1234 CB PHE A 156 -20.072 70.147 -80.175 1.00 12.87 C +ATOM 1235 CG PHE A 156 -19.197 69.885 -78.972 1.00 11.54 C +ATOM 1236 CD1 PHE A 156 -19.719 69.343 -77.808 1.00 12.48 C +ATOM 1237 CD2 PHE A 156 -17.844 70.199 -79.008 1.00 12.82 C +ATOM 1238 CE1 PHE A 156 -18.902 69.127 -76.702 1.00 11.87 C +ATOM 1239 CE2 PHE A 156 -17.030 69.986 -77.909 1.00 11.24 C +ATOM 1240 CZ PHE A 156 -17.562 69.447 -76.757 1.00 11.63 C +ATOM 1241 N TYR A 157 -21.423 69.805 -83.058 1.00 11.73 N +ATOM 1242 CA TYR A 157 -22.616 69.999 -83.887 1.00 13.09 C +ATOM 1243 C TYR A 157 -23.001 68.695 -84.588 1.00 12.45 C +ATOM 1244 O TYR A 157 -24.190 68.417 -84.792 1.00 12.33 O +ATOM 1245 CB TYR A 157 -22.402 71.108 -84.921 1.00 14.58 C +ATOM 1246 CG TYR A 157 -22.293 72.509 -84.357 1.00 16.33 C +ATOM 1247 CD1 TYR A 157 -22.252 72.747 -82.996 1.00 17.65 C +ATOM 1248 CD2 TYR A 157 -22.233 73.600 -85.216 1.00 26.14 C +ATOM 1249 CE1 TYR A 157 -22.148 74.048 -82.496 1.00 25.51 C +ATOM 1250 CE2 TYR A 157 -22.132 74.885 -84.735 1.00 27.99 C +ATOM 1251 CZ TYR A 157 -22.086 75.103 -83.379 1.00 31.14 C +ATOM 1252 OH TYR A 157 -21.989 76.397 -82.917 1.00 37.17 O +ATOM 1253 N THR A 158 -22.021 67.874 -84.955 1.00 11.12 N +ATOM 1254 CA THR A 158 -22.319 66.559 -85.501 1.00 11.43 C +ATOM 1255 C THR A 158 -23.085 65.716 -84.489 1.00 11.71 C +ATOM 1256 O THR A 158 -24.021 64.994 -84.856 1.00 12.24 O +ATOM 1257 CB THR A 158 -21.045 65.834 -85.937 1.00 12.16 C +ATOM 1258 OG1 THR A 158 -20.457 66.561 -87.026 1.00 13.77 O +ATOM 1259 CG2 THR A 158 -21.338 64.417 -86.384 1.00 15.17 C +ATOM 1260 N LEU A 159 -22.711 65.800 -83.217 1.00 10.54 N +ATOM 1261 CA LEU A 159 -23.442 65.061 -82.204 1.00 11.21 C +ATOM 1262 C LEU A 159 -24.902 65.524 -82.141 1.00 11.50 C +ATOM 1263 O LEU A 159 -25.806 64.704 -82.024 1.00 11.87 O +ATOM 1264 CB LEU A 159 -22.746 65.162 -80.851 1.00 10.39 C +ATOM 1265 CG LEU A 159 -23.446 64.401 -79.723 1.00 10.83 C +ATOM 1266 CD1 LEU A 159 -23.620 62.930 -80.038 1.00 12.08 C +ATOM 1267 CD2 LEU A 159 -22.674 64.589 -78.433 1.00 11.81 C +ATOM 1268 N VAL A 160 -25.137 66.824 -82.222 1.00 11.89 N +ATOM 1269 CA VAL A 160 -26.516 67.309 -82.283 1.00 12.08 C +ATOM 1270 C VAL A 160 -27.230 66.749 -83.519 1.00 11.88 C +ATOM 1271 O VAL A 160 -28.381 66.290 -83.425 1.00 12.38 O +ATOM 1272 CB VAL A 160 -26.531 68.834 -82.265 1.00 12.13 C +ATOM 1273 CG1 VAL A 160 -27.927 69.357 -82.605 1.00 13.07 C +ATOM 1274 CG2 VAL A 160 -26.092 69.360 -80.917 1.00 12.76 C +ATOM 1275 N ARG A 161 -26.554 66.729 -84.664 1.00 12.42 N +ATOM 1276 CA ARG A 161 -27.156 66.191 -85.884 1.00 12.74 C +ATOM 1277 C ARG A 161 -27.446 64.678 -85.783 1.00 12.56 C +ATOM 1278 O ARG A 161 -28.368 64.167 -86.424 1.00 15.30 O +ATOM 1279 CB ARG A 161 -26.308 66.538 -87.118 1.00 14.50 C +ATOM 1280 CG ARG A 161 -26.219 68.042 -87.362 1.00 16.17 C +ATOM 1281 CD ARG A 161 -25.282 68.384 -88.500 1.00 19.11 C +ATOM 1282 NE ARG A 161 -25.095 69.828 -88.576 1.00 19.39 N +ATOM 1283 CZ ARG A 161 -23.916 70.441 -88.566 1.00 19.71 C +ATOM 1284 NH1 ARG A 161 -22.790 69.740 -88.525 1.00 20.85 N +ATOM 1285 NH2 ARG A 161 -23.880 71.766 -88.630 1.00 24.45 N +ATOM 1286 N GLU A 162 -26.677 63.962 -84.961 1.00 12.97 N +ATOM 1287 CA GLU A 162 -26.941 62.551 -84.704 1.00 13.12 C +ATOM 1288 C GLU A 162 -28.136 62.372 -83.778 1.00 14.56 C +ATOM 1289 O GLU A 162 -28.970 61.496 -84.011 1.00 15.25 O +ATOM 1290 CB GLU A 162 -25.719 61.878 -84.086 1.00 14.72 C +ATOM 1291 CG GLU A 162 -24.539 61.724 -85.037 1.00 17.97 C +ATOM 1292 CD GLU A 162 -24.813 60.729 -86.166 1.00 18.57 C +ATOM 1293 OE1 GLU A 162 -25.228 59.591 -85.868 1.00 21.61 O +ATOM 1294 OE2 GLU A 162 -24.616 61.087 -87.348 1.00 22.66 O +ATOM 1295 N ILE A 163 -28.221 63.192 -82.737 1.00 11.93 N +ATOM 1296 CA ILE A 163 -29.391 63.148 -81.873 1.00 12.63 C +ATOM 1297 C ILE A 163 -30.662 63.384 -82.711 1.00 13.87 C +ATOM 1298 O ILE A 163 -31.664 62.696 -82.521 1.00 16.54 O +ATOM 1299 CB ILE A 163 -29.297 64.175 -80.735 1.00 12.29 C +ATOM 1300 CG1 ILE A 163 -28.160 63.825 -79.757 1.00 13.38 C +ATOM 1301 CG2 ILE A 163 -30.642 64.306 -80.015 1.00 15.16 C +ATOM 1302 CD1 ILE A 163 -27.818 64.939 -78.789 1.00 15.48 C +ATOM 1303 N ARG A 164 -30.615 64.319 -83.658 1.00 13.35 N +ATOM 1304 CA ARG A 164 -31.783 64.609 -84.509 1.00 13.36 C +ATOM 1305 C ARG A 164 -32.197 63.473 -85.442 1.00 15.23 C +ATOM 1306 O ARG A 164 -33.317 63.467 -85.952 1.00 19.47 O +ATOM 1307 CB ARG A 164 -31.532 65.869 -85.348 1.00 14.52 C +ATOM 1308 CG ARG A 164 -31.393 67.151 -84.542 1.00 11.67 C +ATOM 1309 CD ARG A 164 -30.797 68.229 -85.432 1.00 14.48 C +ATOM 1310 NE ARG A 164 -30.767 69.555 -84.826 1.00 13.12 N +ATOM 1311 CZ ARG A 164 -30.098 70.572 -85.352 1.00 14.55 C +ATOM 1312 NH1 ARG A 164 -29.413 70.393 -86.479 1.00 16.92 N +ATOM 1313 NH2 ARG A 164 -30.105 71.759 -84.750 1.00 16.00 N +ATOM 1314 N GLN A 165 -31.311 62.527 -85.698 1.00 15.57 N +ATOM 1315 CA GLN A 165 -31.649 61.363 -86.501 1.00 17.65 C +ATOM 1316 C GLN A 165 -32.278 60.252 -85.671 1.00 21.17 C +ATOM 1317 O GLN A 165 -32.804 59.288 -86.227 1.00 21.68 O +ATOM 1318 CB GLN A 165 -30.411 60.823 -87.211 1.00 16.74 C +ATOM 1319 CG GLN A 165 -29.894 61.748 -88.292 1.00 16.28 C +ATOM 1320 CD GLN A 165 -28.603 61.259 -88.870 1.00 17.19 C +ATOM 1321 OE1 GLN A 165 -28.567 60.237 -89.563 1.00 23.26 O +ATOM 1322 NE2 GLN A 165 -27.527 61.977 -88.588 1.00 19.66 N +ATOM 1323 N HIS A 166 -32.209 60.387 -84.350 1.00 21.90 N +ATOM 1324 CA HIS A 166 -32.681 59.352 -83.434 1.00 25.37 C +ATOM 1325 C HIS A 166 -34.203 59.346 -83.345 1.00 33.41 C +ATOM 1326 O HIS A 166 -34.810 58.333 -82.993 1.00 44.64 O +ATOM 1327 CB HIS A 166 -32.064 59.563 -82.046 1.00 30.90 C +ATOM 1328 CG HIS A 166 -32.474 58.538 -81.032 1.00 39.35 C +ATOM 1329 ND1 HIS A 166 -31.806 57.344 -80.867 1.00 39.02 N +ATOM 1330 CD2 HIS A 166 -33.481 58.533 -80.125 1.00 42.92 C +ATOM 1331 CE1 HIS A 166 -32.383 56.647 -79.904 1.00 36.38 C +ATOM 1332 NE2 HIS A 166 -33.403 57.344 -79.438 1.00 44.85 N +ATOM 1333 OXT HIS A 166 -34.866 60.349 -83.618 1.00 32.80 O +TER 1334 HIS A 166 +HETATM 1335 CA CA A 191 -4.605 79.050 -72.103 1.00 13.49 CA +HETATM 1336 MG MG A 192 -11.514 67.194 -67.533 1.00 11.66 MG +HETATM 1337 MG MG A 194 0.000 51.108 -85.146 0.33 29.01 MG +HETATM 1338 S1 DTU A 201 -16.195 53.208 -67.086 1.00 57.59 S +HETATM 1339 C1 DTU A 201 -14.391 53.422 -67.326 1.00 40.55 C +HETATM 1340 C2 DTU A 201 -13.875 52.230 -68.107 1.00 34.25 C +HETATM 1341 O2 DTU A 201 -14.562 52.273 -69.348 1.00 41.80 O +HETATM 1342 C3 DTU A 201 -12.373 52.252 -68.386 1.00 37.76 C +HETATM 1343 O3 DTU A 201 -11.631 52.389 -67.169 1.00 49.58 O +HETATM 1344 C4 DTU A 201 -12.006 50.953 -69.118 1.00 38.92 C +HETATM 1345 S4 DTU A 201 -10.235 50.765 -69.525 1.00 65.09 S +HETATM 1346 CA CA A 196 -29.005 50.239 -67.030 0.50 28.86 CA +HETATM 1347 PG GNP A 190 -9.922 64.481 -66.958 1.00 12.72 P +HETATM 1348 O1G GNP A 190 -8.974 64.079 -65.853 1.00 13.89 O +HETATM 1349 O2G GNP A 190 -10.821 65.586 -66.518 1.00 14.01 O +HETATM 1350 O3G GNP A 190 -10.663 63.245 -67.424 1.00 16.08 O +HETATM 1351 N3B GNP A 190 -9.030 65.014 -68.209 1.00 12.28 N +HETATM 1352 PB GNP A 190 -9.543 65.696 -69.605 1.00 11.22 P +HETATM 1353 O1B GNP A 190 -9.907 64.660 -70.603 1.00 10.60 O +HETATM 1354 O2B GNP A 190 -10.615 66.679 -69.348 1.00 11.99 O +HETATM 1355 O3A GNP A 190 -8.310 66.467 -70.185 1.00 10.49 O +HETATM 1356 PA GNP A 190 -7.990 68.026 -70.207 1.00 11.07 P +HETATM 1357 O1A GNP A 190 -8.914 68.704 -71.121 1.00 10.76 O +HETATM 1358 O2A GNP A 190 -7.834 68.486 -68.815 1.00 12.77 O +HETATM 1359 O5' GNP A 190 -6.600 68.095 -70.950 1.00 10.66 O +HETATM 1360 C5' GNP A 190 -5.498 67.357 -70.436 1.00 12.81 C +HETATM 1361 C4' GNP A 190 -4.219 67.990 -70.933 1.00 12.64 C +HETATM 1362 O4' GNP A 190 -4.130 67.807 -72.370 1.00 12.03 O +HETATM 1363 C3' GNP A 190 -4.093 69.496 -70.711 1.00 12.60 C +HETATM 1364 O3' GNP A 190 -2.711 69.805 -70.433 1.00 13.26 O +HETATM 1365 C2' GNP A 190 -4.530 70.105 -72.041 1.00 11.58 C +HETATM 1366 O2' GNP A 190 -3.918 71.342 -72.357 1.00 12.39 O +HETATM 1367 C1' GNP A 190 -4.014 69.055 -73.018 1.00 12.87 C +HETATM 1368 N9 GNP A 190 -4.785 69.015 -74.253 1.00 11.63 N +HETATM 1369 C8 GNP A 190 -6.153 68.823 -74.340 1.00 11.49 C +HETATM 1370 N7 GNP A 190 -6.584 68.872 -75.569 1.00 10.62 N +HETATM 1371 C5 GNP A 190 -5.439 69.097 -76.333 1.00 9.94 C +HETATM 1372 C6 GNP A 190 -5.289 69.218 -77.726 1.00 11.28 C +HETATM 1373 O6 GNP A 190 -6.169 69.143 -78.601 1.00 12.69 O +HETATM 1374 N1 GNP A 190 -3.964 69.440 -78.107 1.00 12.33 N +HETATM 1375 C2 GNP A 190 -2.919 69.529 -77.218 1.00 13.16 C +HETATM 1376 N2 GNP A 190 -1.705 69.750 -77.755 1.00 16.04 N +HETATM 1377 N3 GNP A 190 -3.046 69.399 -75.901 1.00 12.00 N +HETATM 1378 C4 GNP A 190 -4.327 69.180 -75.531 1.00 10.66 C +HETATM 1379 O HOH A 175 -10.812 63.093 -63.916 1.00 17.06 O +HETATM 1380 O HOH A 301 -9.812 68.385 -67.009 1.00 13.99 O +HETATM 1381 O HOH A 302 -15.443 59.918 -68.880 1.00 13.64 O +HETATM 1382 O HOH A 304 -7.357 70.834 -67.481 1.00 13.35 O +HETATM 1383 O HOH A 306 -10.818 57.410 -74.019 1.00 12.33 O +HETATM 1384 O HOH A 307 -9.756 74.643 -73.841 1.00 13.03 O +HETATM 1385 O HOH A 308 -8.139 57.037 -67.442 1.00 24.12 O +HETATM 1386 O HOH A 309 -4.127 79.812 -74.374 1.00 19.99 O +HETATM 1387 O HOH A 310 -14.643 71.394 -66.905 1.00 22.03 O +HETATM 1388 O HOH A 311 -29.694 68.444 -88.458 1.00 13.74 O +HETATM 1389 O HOH A 312 -6.360 80.346 -76.269 1.00 18.46 O +HETATM 1390 O HOH A 313 -2.638 62.381 -74.623 1.00 18.64 O +HETATM 1391 O HOH A 314 -14.098 74.410 -84.610 1.00 17.10 O +HETATM 1392 O HOH A 315 -22.096 67.082 -89.286 1.00 23.08 O +HETATM 1393 O HOH A 316 -29.509 65.680 -88.671 1.00 14.10 O +HETATM 1394 O HOH A 317 -3.722 59.040 -89.801 1.00 27.16 O +HETATM 1395 O HOH A 318 -12.265 73.033 -88.245 1.00 29.04 O +HETATM 1396 O HOH A 320 -24.647 58.422 -83.619 1.00 21.64 O +HETATM 1397 O HOH A 321 -15.002 72.504 -86.499 1.00 19.03 O +HETATM 1398 O HOH A 322 -25.861 81.494 -73.717 1.00 28.22 O +HETATM 1399 O HOH A 323 -6.456 65.695 -88.019 1.00 25.06 O +HETATM 1400 O HOH A 324 -24.995 80.975 -82.557 1.00 34.30 O +HETATM 1401 O HOH A 325 -2.164 48.790 -74.707 1.00 19.09 O +HETATM 1402 O HOH A 326 -14.957 69.344 -61.208 1.00 26.70 O +HETATM 1403 O HOH A 327 -1.096 71.588 -73.125 1.00 23.04 O +HETATM 1404 O HOH A 328 -7.924 74.584 -65.265 1.00 24.86 O +HETATM 1405 O HOH A 329 0.659 71.899 -80.808 1.00 26.89 O +HETATM 1406 O HOH A 330 -17.376 61.634 -61.099 1.00 28.73 O +HETATM 1407 O HOH A 331 -11.501 67.283 -88.262 1.00 22.43 O +HETATM 1408 O HOH A 332 -13.783 68.992 -89.169 1.00 26.89 O +HETATM 1409 O HOH A 333 -1.473 67.173 -74.301 1.00 19.61 O +HETATM 1410 O HOH A 334 0.826 70.227 -76.068 1.00 34.50 O +HETATM 1411 O HOH A 336 -12.104 50.474 -77.801 1.00 22.19 O +HETATM 1412 O HOH A 337 -20.388 72.671 -63.015 1.00 21.03 O +HETATM 1413 O HOH A 338 -2.805 52.466 -82.069 1.00 29.71 O +HETATM 1414 O HOH A 339 -25.265 75.946 -88.291 1.00 27.25 O +HETATM 1415 O HOH A 341 -8.667 69.064 -60.109 1.00 27.57 O +HETATM 1416 O HOH A 342 0.755 53.056 -83.608 1.00 29.12 O +HETATM 1417 O HOH A 343 -33.642 67.669 -74.480 1.00 22.32 O +HETATM 1418 O HOH A 344 -11.028 47.890 -77.133 1.00 24.64 O +HETATM 1419 O HOH A 345 -12.458 56.524 -66.515 1.00 34.22 O +HETATM 1420 O HOH A 346 -16.977 55.745 -89.310 1.00 23.67 O +HETATM 1421 O HOH A 347 -27.442 58.220 -89.893 1.00 22.87 O +HETATM 1422 O HOH A 348 -11.454 70.174 -64.638 1.00 19.50 O +HETATM 1423 O HOH A 349 -0.587 71.145 -65.721 1.00 23.13 O +HETATM 1424 O HOH A 350 -18.869 71.504 -60.999 1.00 21.06 O +HETATM 1425 O HOH A 351 -0.187 64.788 -74.853 1.00 24.93 O +HETATM 1426 O HOH A 352 -13.262 70.569 -62.604 1.00 24.58 O +HETATM 1427 O HOH A 353 -25.231 74.031 -66.084 1.00 27.81 O +HETATM 1428 O HOH A 354 -22.908 75.875 -66.025 1.00 22.27 O +HETATM 1429 O HOH A 355 -6.438 70.348 -59.945 1.00 28.10 O +HETATM 1430 O HOH A 357 -14.221 77.358 -85.179 1.00 27.33 O +HETATM 1431 O HOH A 359 -27.267 78.029 -88.293 1.00 26.25 O +HETATM 1432 O HOH A 360 -20.304 62.907 -89.476 1.00 30.63 O +HETATM 1433 O HOH A 361 -5.042 56.636 -91.879 1.00 28.60 O +HETATM 1434 O HOH A 363 -17.935 49.359 -69.148 1.00 30.96 O +HETATM 1435 O HOH A 364 -1.172 53.036 -86.003 1.00 32.29 O +HETATM 1436 O HOH A 365 -9.659 55.078 -68.749 1.00 30.12 O +HETATM 1437 O HOH A 366 -0.294 60.165 -74.460 1.00 28.20 O +HETATM 1438 O HOH A 368 -23.007 80.221 -71.738 1.00 32.61 O +HETATM 1439 O HOH A 369 -15.507 48.276 -89.119 1.00 29.40 O +HETATM 1440 O HOH A 370 0.000 51.108 -74.882 0.33 20.81 O +HETATM 1441 O HOH A 371 -18.799 48.721 -76.896 1.00 33.14 O +HETATM 1442 O HOH A 372 -31.209 60.605 -77.421 1.00 31.64 O +HETATM 1443 O HOH A 373 -8.502 48.520 -88.072 1.00 36.03 O +HETATM 1444 O HOH A 374 -5.110 56.345 -70.703 1.00 30.54 O +HETATM 1445 O HOH A 375 -9.358 72.449 -66.509 1.00 26.80 O +HETATM 1446 O HOH A 376 -1.885 78.280 -75.333 1.00 31.65 O +HETATM 1447 O HOH A 377 -4.432 61.077 -73.122 1.00 25.79 O +HETATM 1448 O HOH A 379 -0.695 63.876 -86.014 1.00 36.99 O +HETATM 1449 O HOH A 380 -32.926 55.471 -72.696 1.00 38.11 O +HETATM 1450 O HOH A 381 1.872 62.418 -87.305 1.00 34.74 O +HETATM 1451 O HOH A 383 -2.690 65.065 -87.258 1.00 35.68 O +HETATM 1452 O HOH A 384 -29.147 57.436 -88.585 1.00 35.39 O +HETATM 1453 O HOH A 385 -32.964 80.571 -85.119 1.00 35.96 O +HETATM 1454 O HOH A 388 -12.281 78.350 -67.960 1.00 35.40 O +HETATM 1455 O HOH A 389 -10.083 77.602 -67.677 1.00 38.55 O +HETATM 1456 O HOH A 390 -0.677 68.287 -71.759 1.00 28.26 O +HETATM 1457 O HOH A 391 -35.347 77.892 -83.668 1.00 38.01 O +HETATM 1458 O HOH A 392 -24.605 59.597 -89.373 0.50 33.98 O +HETATM 1459 O HOH A 394 -22.208 53.690 -79.986 1.00 36.53 O +HETATM 1460 O HOH A 395 0.255 73.979 -73.703 1.00 33.62 O +HETATM 1461 O HOH A 396 -30.660 53.105 -67.030 0.50 33.86 O +HETATM 1462 O HOH A 397 -23.691 81.214 -78.850 1.00 37.57 O +HETATM 1463 O HOH A 398 -5.729 58.218 -68.607 1.00 30.70 O +HETATM 1464 O HOH A 401 -17.577 47.272 -89.152 1.00 37.96 O +HETATM 1465 O HOH A 405 -20.810 77.061 -80.748 1.00 38.99 O +HETATM 1466 O HOH A 406 -3.513 61.252 -70.527 1.00 33.92 O +HETATM 1467 O HOH A 407 -22.919 62.518 -89.373 0.50 29.69 O +HETATM 1468 O HOH A 408 -11.152 83.994 -75.882 1.00 35.52 O +HETATM 1469 O HOH A 409 -7.616 79.058 -78.700 1.00 31.07 O +HETATM 1470 O HOH A 410 -2.383 71.615 -86.476 1.00 33.49 O +HETATM 1471 O HOH A 412 -12.057 81.081 -67.679 1.00 21.53 O +HETATM 1472 O HOH A 413 -4.874 71.233 -85.585 1.00 23.70 O +HETATM 1473 O HOH A 414 -2.126 70.605 -62.981 1.00 31.27 O +HETATM 1474 O HOH A 415 -4.573 77.945 -78.531 1.00 35.49 O +HETATM 1475 O HOH A 416 -7.780 56.213 -64.649 1.00 34.94 O +HETATM 1476 O HOH A 418 -23.087 47.604 -71.231 1.00 38.18 O +HETATM 1477 O HOH A 421 -28.004 82.797 -80.389 1.00 43.97 O +HETATM 1478 O HOH A 423 -2.091 64.868 -71.100 1.00 37.01 O +HETATM 1479 O HOH A 424 -7.279 57.973 -61.143 1.00 36.75 O +HETATM 1480 O HOH A 427 -0.306 78.680 -70.358 1.00 31.41 O +HETATM 1481 O HOH A 428 -0.271 68.674 -69.310 1.00 39.24 O +HETATM 1482 O HOH A 430 4.288 66.890 -82.332 1.00 27.57 O +HETATM 1483 O HOH A 434 -1.196 55.469 -72.023 1.00 35.06 O +HETATM 1484 O HOH A 436 -2.467 78.123 -77.891 1.00 38.13 O +HETATM 1485 O HOH A 440 0.000 51.108 -88.025 0.33 39.56 O +HETATM 1486 O HOH A 442 -5.682 68.807 -91.238 1.00 36.18 O +HETATM 1487 O HOH A 443 -19.858 69.279 -60.064 1.00 22.57 O +HETATM 1488 O HOH A 452 -3.534 62.976 -62.402 1.00 45.70 O +HETATM 1489 O HOH A 454 -25.634 72.422 -68.294 1.00 24.47 O +HETATM 1490 O HOH A 461 -28.367 47.215 -73.299 1.00 49.17 O +HETATM 1491 O HOH A 462 2.714 63.810 -78.841 1.00 31.73 O +HETATM 1492 O HOH A 463 -6.234 48.104 -73.333 1.00 34.56 O +HETATM 1493 O HOH A 468 -9.650 80.273 -79.507 1.00 35.96 O +HETATM 1494 O HOH A 469 -21.942 69.316 -61.572 1.00 36.96 O +HETATM 1495 O HOH A 474 -25.725 55.999 -84.202 1.00 29.83 O +HETATM 1496 O HOH A 475 -33.169 59.914 -69.182 1.00 39.40 O +HETATM 1497 O HOH A 476 -8.934 49.694 -72.231 1.00 35.04 O +HETATM 1498 O HOH A 485 -20.544 45.998 -86.439 1.00 41.44 O +HETATM 1499 O HOH A 495 -1.159 76.157 -82.236 1.00 41.65 O +HETATM 1500 O HOH A 500 -16.363 83.496 -75.330 1.00 35.53 O +HETATM 1501 O HOH A 503 -0.427 76.459 -68.124 1.00 32.76 O +HETATM 1502 O HOH A 504 -32.362 59.979 -74.483 1.00 38.35 O +HETATM 1503 O HOH A 505 -27.250 58.171 -87.104 1.00 37.33 O +HETATM 1504 O HOH A 507 -34.595 67.620 -82.025 1.00 38.94 O +HETATM 1505 O HOH A 508 -9.544 82.735 -78.044 1.00 34.08 O +HETATM 1506 O HOH A 510 -23.517 48.778 -84.289 1.00 39.66 O +HETATM 1507 O HOH A 519 -14.220 52.534 -92.423 1.00 36.06 O +HETATM 1508 O HOH A 524 -3.822 59.282 -66.377 1.00 40.85 O +HETATM 1509 O HOH A 539 -19.418 73.066 -87.335 1.00 33.74 O +HETATM 1510 O HOH A 542 -18.376 55.198 -63.535 1.00 40.66 O +HETATM 1511 O HOH A 543 4.224 65.819 -79.762 1.00 24.70 O +HETATM 1512 O HOH A 544 -13.282 66.171 -68.119 1.00 13.42 O +HETATM 1513 O HOH A 545 -25.703 55.396 -86.649 1.00 22.23 O +HETATM 1514 O HOH A1471 -18.971 74.352 -64.743 1.00 22.31 O +HETATM 1515 O HOH A1472 -9.083 49.634 -85.692 1.00 28.55 O +HETATM 1516 O HOH A1473 -11.902 69.598 -60.580 1.00 31.17 O +HETATM 1517 O HOH A1474 -2.500 80.158 -71.271 1.00 25.03 O +HETATM 1518 O HOH A1475 -32.737 58.399 -88.810 1.00 25.52 O +HETATM 1519 O HOH A1476 -16.692 78.281 -80.068 1.00 31.99 O +HETATM 1520 O HOH A1477 -34.278 65.881 -79.240 1.00 42.87 O +HETATM 1521 O HOH A1478 2.569 64.501 -88.842 1.00 37.63 O +HETATM 1522 O HOH A1479 -36.449 75.452 -81.663 1.00 39.26 O +HETATM 1523 O HOH A1480 -26.656 62.940 -60.020 1.00 48.85 O +HETATM 1524 O HOH A1481 -20.950 61.708 -91.093 1.00 28.03 O +HETATM 1525 O HOH A1482 -36.387 63.885 -82.447 1.00 38.48 O +HETATM 1526 O HOH A1483 -9.985 75.520 -87.346 1.00 37.31 O +HETATM 1527 O HOH A1484 -28.320 80.565 -71.732 1.00 46.40 O +HETATM 1528 O HOH A1485 -10.354 49.635 -97.688 1.00 51.72 O +HETATM 1529 O HOH A1486 -15.523 75.329 -89.373 0.50 47.08 O +HETATM 1530 O HOH A1487 -18.362 62.585 -57.146 1.00 48.07 O +HETATM 1531 O HOH A1488 -7.580 75.323 -87.616 1.00 41.53 O +HETATM 1532 O HOH A1489 1.791 61.440 -73.240 1.00 41.02 O +HETATM 1533 O HOH A1490 0.133 67.753 -65.081 1.00 42.31 O +HETATM 1534 O HOH A1491 -32.894 54.532 -86.444 1.00 52.43 O +HETATM 1535 O HOH A1492 -6.355 78.411 -84.227 1.00 40.86 O +HETATM 1536 O HOH A1493 2.191 70.389 -83.722 1.00 38.07 O +HETATM 1537 O HOH A1494 1.066 70.828 -68.921 1.00 42.55 O +HETATM 1538 O HOH A1495 -30.001 79.135 -68.323 1.00 45.19 O +HETATM 1539 O HOH A1496 -28.063 44.266 -76.247 1.00 52.44 O +HETATM 1540 O HOH A1497 -26.805 46.427 -67.030 0.50 40.65 O +HETATM 1541 O HOH A1498 0.153 71.149 -85.454 1.00 38.53 O +HETATM 1542 O HOH A1499 -26.644 67.082 -65.230 1.00 42.76 O +HETATM 1543 O HOH A1500 -37.926 69.766 -79.878 1.00 47.17 O +HETATM 1544 O HOH A1501 0.900 73.143 -67.122 1.00 44.78 O +HETATM 1545 O HOH A1502 -31.249 69.957 -67.758 1.00 46.38 O +HETATM 1546 O HOH A1503 -29.285 70.413 -66.934 1.00 38.85 O +HETATM 1547 O HOH A1504 -28.641 56.612 -61.259 1.00 44.87 O +HETATM 1548 O HOH A1505 -1.736 69.583 -87.738 1.00 45.63 O +HETATM 1549 O HOH A1506 -10.234 55.390 -95.425 1.00 36.62 O +HETATM 1550 O HOH A1507 -2.266 77.491 -80.049 1.00 44.35 O +HETATM 1551 O HOH A1508 -24.768 54.454 -81.633 1.00 35.49 O +CONECT 117 1336 +CONECT 201 1335 +CONECT 222 1335 +CONECT 265 1336 +CONECT 808 1346 +CONECT 845 1346 +CONECT 846 1346 +CONECT 1335 201 222 1386 1517 +CONECT 1336 117 265 1349 1354 +CONECT 1336 1380 1512 +CONECT 1337 1416 1435 1485 +CONECT 1338 1339 +CONECT 1339 1338 1340 +CONECT 1340 1339 1341 1342 +CONECT 1341 1340 +CONECT 1342 1340 1343 1344 +CONECT 1343 1342 +CONECT 1344 1342 1345 +CONECT 1345 1344 +CONECT 1346 808 845 846 +CONECT 1347 1348 1349 1350 1351 +CONECT 1348 1347 +CONECT 1349 1336 1347 +CONECT 1350 1347 +CONECT 1351 1347 1352 +CONECT 1352 1351 1353 1354 1355 +CONECT 1353 1352 +CONECT 1354 1336 1352 +CONECT 1355 1352 1356 +CONECT 1356 1355 1357 1358 1359 +CONECT 1357 1356 +CONECT 1358 1356 +CONECT 1359 1356 1360 +CONECT 1360 1359 1361 +CONECT 1361 1360 1362 1363 +CONECT 1362 1361 1367 +CONECT 1363 1361 1364 1365 +CONECT 1364 1363 +CONECT 1365 1363 1366 1367 +CONECT 1366 1365 +CONECT 1367 1362 1365 1368 +CONECT 1368 1367 1369 1378 +CONECT 1369 1368 1370 +CONECT 1370 1369 1371 +CONECT 1371 1370 1372 1378 +CONECT 1372 1371 1373 1374 +CONECT 1373 1372 +CONECT 1374 1372 1375 +CONECT 1375 1374 1376 1377 +CONECT 1376 1375 +CONECT 1377 1375 1378 +CONECT 1378 1368 1371 1377 +CONECT 1380 1336 +CONECT 1386 1335 +CONECT 1416 1337 +CONECT 1435 1337 +CONECT 1485 1337 +CONECT 1512 1336 +CONECT 1517 1335 +MASTER 398 0 6 7 6 0 16 6 1526 1 59 13 +END diff --git a/test/test-2/data/UniprotMap-P01112.pkl b/test/test-2/data/UniprotMap-P01112.pkl new file mode 100644 index 0000000000000000000000000000000000000000..e7334c3d0481c2c821eb1db836fa536a3adc80ff GIT binary patch literal 1018673 zcmbTfbzl|8`u|Ve-Tl<5yZ6@Jd)r%g zcXxN!+xE7<*E0z-Pm=AY_xJsShkZRe&&hjdcSm++XZK&IMcOj6y7H}a)6=qHVE-S643InM$RK3rn;u zI>=j6SknF0h~Xn9)f5+&8kC^4u(V6CQ%QMoRdHdNK?%wV%l0Oy7(I4!bz!+d3Cau0 z_a>+w(O5COu)?4O!wW0+C73j_wzRO4JJ!xjN7kuc*&SYEP1D#t#!jlQX(+5RWho9# zb1|FiJ+M_<_UdR)XS*evP1m+(JF=bK&1^5(x4mRxHF9_LxUfcV?sjLU7uKAzAwRNr zTX*-Yt%eOFWA*pad6_yWLl}(Lp%ybosdUs}W?S=G|1xUAKVOY=9 zjQxq?xKI*)qO@&T2q|kLu{(hBxG+2%K*itYOs2g%E1j9{-0ZA7j>-YYQ56-c-4AaS z7q$*RyiMD{1Ku_&Y-iPO9~X8AYHOw}#xad8;!ul93L}E@k*d7kVUCImwIOh{J||v(#)YQv*PGq0u^H7}m=sh`9;ABb 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pph2_TPR pph2_FDR site region PHAT dScore Score1 Score2 MSAv Nobs Nstruct Nfilt PDB_id PDB_pos PDB_ch ident length NormASA SecStr MapReg dVol dProp B-fact H-bonds AveNHet MinDHet AveNInt MinDInt AveNSit MinDSit Transv CodPos CpG MinDJxn PfamHit IdPmax IdPSNP IdQmin +P01112 1 M A ? P01112 1 M A ? ? probably damaging sequence annotation 2.2 deleterious 0.986 0.0368 0.736 0.0634 MOD_RES NO ? +1.835 -1.229 -3.064 2 184 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NO 3.238 ? 72.49 +P01112 1 M C ? P01112 1 M C ? ? probably damaging sequence annotation 2.2 deleterious 0.999 0.00574 0.136 0.0192 MOD_RES NO ? +3.394 -1.229 -4.623 2 184 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NO 1.149 ? 72.49 +P01112 1 M D ? P01112 1 M D ? ? probably damaging sequence annotation 2.2 deleterious 0.998 0.0112 0.273 0.0274 MOD_RES NO ? +2.718 -1.229 -3.947 2 184 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NO 1.114 ? 72.49 +P01112 1 M E ? P01112 1 M E ? ? probably damaging sequence annotation 2.2 deleterious 0.998 0.0112 0.273 0.0274 MOD_RES NO ? +2.464 -1.229 -3.693 2 184 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NO 1.468 ? 72.49 +P01112 1 M F ? P01112 1 M F ? ? probably damaging sequence annotation 2.2 deleterious 0.986 0.0368 0.736 0.0634 MOD_RES NO ? +2.374 -1.229 -3.603 2 184 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NO 3.969 ? 72.49 +P01112 1 M G ? P01112 1 M G ? ? probably damaging sequence annotation 2.2 deleterious 0.998 0.0112 0.273 0.0274 MOD_RES NO ? +2.382 -1.229 -3.611 2 184 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NO 1.529 ? 72.49 +P01112 1 M H ? P01112 1 M H ? ? probably damaging sequence annotation 2.2 deleterious 0.999 0.00574 0.136 0.0192 MOD_RES NO ? +3.479 -1.229 -4.708 2 184 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NO 0.723 ? 72.49 +P01112 1 M I ? P01112 1 M I G C possibly damaging sequence annotation 2.2 deleterious 0.883 0.0643 0.823 0.0957 MOD_RES NO ? +1.817 -1.229 -3.046 2 184 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 1 2 0 -56 NO 8.342 ? 72.49 +P01112 1 M K ? P01112 1 M K T A probably damaging sequence annotation 2.2 deleterious 0.991 0.0326 0.711 0.0584 MOD_RES NO ? +2.256 -1.229 -3.485 2 184 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 1 1 0 -55 NO 1.805 ? 72.49 +P01112 1 M L ? P01112 1 M L A C benign sequence annotation 2.2 neutral 0.045 0.169 0.942 0.196 MOD_RES NO ? +0.589 -1.229 -1.818 2 184 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 1 0 0 -54 NO 27.220 27.220 72.49 +P01112 1 M N ? P01112 1 M N ? ? probably damaging sequence annotation 2.2 deleterious 0.998 0.0112 0.273 0.0274 MOD_RES NO ? +2.697 -1.229 -3.926 2 184 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NO 1.003 ? 72.49 +P01112 1 M P ? P01112 1 M P ? ? probably damaging sequence annotation 2.2 deleterious 0.998 0.0112 0.273 0.0274 MOD_RES NO ? +2.679 -1.229 -3.908 2 184 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NO 1.037 ? 72.49 +P01112 1 M Q ? P01112 1 M Q ? ? probably damaging sequence annotation 2.2 deleterious 0.998 0.0112 0.273 0.0274 MOD_RES NO ? +2.509 -1.229 -3.738 2 184 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NO 1.185 ? 72.49 +P01112 1 M R ? P01112 1 M R T G probably damaging sequence annotation 2.2 deleterious 0.991 0.0326 0.711 0.0584 MOD_RES NO ? +2.507 -1.229 -3.736 2 184 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 1 1 0 -55 NO 1.773 ? 72.49 +P01112 1 M S ? P01112 1 M S ? ? probably damaging sequence annotation 2.2 deleterious 0.993 0.0301 0.696 0.0553 MOD_RES NO ? +2.185 -1.229 -3.414 2 184 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NO 1.779 ? 72.49 +P01112 1 M T ? P01112 1 M T T C probably damaging sequence annotation 2.2 deleterious 0.991 0.0326 0.711 0.0584 MOD_RES NO ? +2.178 -1.229 -3.407 2 184 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 0 1 2 -55 NO 2.436 ? 72.49 +P01112 1 M V ? P01112 1 M V A G possibly damaging sequence annotation 2.2 deleterious 0.883 0.0643 0.823 0.0957 MOD_RES NO ? +1.611 -1.229 -2.840 2 184 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 0 0 0 -54 NO 6.947 ? 72.49 +P01112 1 M W ? P01112 1 M W ? ? probably damaging sequence annotation 2.2 deleterious 0.999 0.00574 0.136 0.0192 MOD_RES NO ? +3.672 -1.229 -4.901 2 184 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NO 0.537 ? 72.49 +P01112 1 M Y ? P01112 1 M Y ? ? probably damaging sequence annotation 2.2 deleterious 0.993 0.0301 0.696 0.0553 MOD_RES NO ? +2.694 -1.229 -3.923 2 184 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NO 1.619 ? 72.49 +P01112 2 T A ? P01112 2 T A A G benign sequence annotation 2.2 neutral 0.037 0.176 0.945 0.201 MOD_RES NO ? +1.041 -1.534 -2.575 2 189 20 20 6q21 2 D 1.00 171 0.194 E B -28 0.22 -0.26 ? ? ? 3 3.345 ? ? 0 0 0 -57 NO 16.399 16.399 79.89 +P01112 2 T C ? P01112 2 T C ? ? probably damaging sequence annotation 2.2 deleterious 0.998 0.0112 0.273 0.0274 MOD_RES NO ? +3.390 -1.534 -4.924 2 189 20 20 6q21 2 D 1.00 171 0.194 E B -8 0.68 -0.26 ? ? ? 3 3.345 ? ? ? ? ? ? NO 1.456 ? 79.89 +P01112 2 T D ? P01112 2 T D ? ? possibly damaging sequence annotation 2.2 deleterious 0.796 0.0729 0.844 0.105 MOD_RES NO ? +2.068 -1.534 -3.602 2 189 20 20 6q21 2 D 1.00 171 0.194 E B -5 0.53 -0.26 ? ? ? 3 3.345 ? ? ? ? ? ? NO 4.980 ? 79.89 +P01112 2 T E ? P01112 2 T E ? ? benign sequence annotation 2.2 neutral 0.345 0.109 0.9 0.142 MOD_RES NO ? +1.268 -1.534 -2.802 2 189 20 20 6q21 2 D 1.00 171 0.194 E B 22 0.82 -0.26 ? ? ? 3 3.345 ? ? ? ? ? ? NO 16.346 16.346 79.89 +P01112 2 T F ? P01112 2 T F ? ? possibly damaging sequence annotation 2.2 deleterious 0.527 0.0957 0.881 0.128 MOD_RES NO ? +1.546 -1.534 -3.080 2 189 20 20 6q21 2 D 1.00 171 0.194 E B 74 0.8 -0.26 ? ? ? 3 3.345 ? ? ? ? ? ? NO 20.802 20.802 79.89 +P01112 2 T G ? P01112 2 T G ? ? probably damaging sequence annotation 2.2 deleterious 0.97 0.0446 0.769 0.0728 MOD_RES NO ? +1.926 -1.534 -3.460 2 189 20 20 6q21 2 D 1.00 171 0.194 E B -56 0.07 -0.26 ? ? ? 3 3.345 ? ? ? ? ? ? NO 5.353 ? 79.89 +P01112 2 T H ? P01112 2 T H ? ? probably damaging sequence annotation 2.2 deleterious 0.996 0.0222 0.545 0.0439 MOD_RES NO ? +3.144 -1.534 -4.678 2 189 20 20 6q21 2 D 1.00 171 0.194 E B 37 0.05 -0.26 ? ? ? 3 3.345 ? ? ? ? ? ? NO 1.830 ? 79.89 +P01112 2 T I ? P01112 2 T I ? ? possibly damaging sequence annotation 2.2 deleterious 0.948 0.0532 0.793 0.0833 MOD_RES NO ? +2.145 -1.534 -3.679 2 189 20 20 6q21 2 D 1.00 171 0.194 E B 51 0.7 -0.26 ? ? ? 3 3.345 ? ? ? ? ? ? NO 7.855 ? 79.89 +P01112 2 T K ? P01112 2 T K C A probably damaging sequence annotation 2.2 deleterious 0.972 0.0442 0.766 0.0725 MOD_RES NO ? +1.972 -1.534 -3.506 2 189 20 20 6q21 2 D 1.00 171 0.194 E B 52 2.12 -0.26 ? ? ? 3 3.345 ? ? 1 1 1 -58 NO 8.755 ? 79.89 +P01112 2 T L ? P01112 2 T L ? ? benign sequence annotation 2.2 neutral 0.147 0.135 0.922 0.165 MOD_RES NO ? +1.169 -1.534 -2.703 2 189 20 20 6q21 2 D 1.00 171 0.194 E B 51 0.77 -0.26 ? ? ? 3 3.345 ? ? ? ? ? ? NO 25.630 25.630 79.89 +P01112 2 T M ? P01112 2 T M C T probably damaging sequence annotation 2.2 deleterious 0.998 0.0112 0.273 0.0274 MOD_RES NO ? +3.019 -1.534 -4.553 2 189 20 20 6q21 2 D 1.00 171 0.194 E B 47 0.77 -0.26 ? ? ? 3 3.345 ? ? 0 1 1 -58 NO 3.402 ? 79.89 +P01112 2 T N ? P01112 2 T N ? ? benign sequence annotation 2.2 neutral 0.136 0.138 0.924 0.168 MOD_RES NO ? +1.354 -1.534 -2.888 2 189 20 20 6q21 2 D 1.00 171 0.194 E B -2 0.39 -0.26 ? ? ? 3 3.345 ? ? ? ? ? ? NO 18.098 18.098 79.89 +P01112 2 T P ? P01112 2 T P A C benign sequence annotation 2.2 neutral 0.063 0.16 0.937 0.187 MOD_RES NO ? +1.383 -1.534 -2.917 2 189 20 20 6q21 2 D 1.00 171 0.194 E B -4 0.3 -0.26 ? ? ? 3 3.345 ? ? 1 0 0 -57 NO 37.694 37.694 79.89 +P01112 2 T Q ? P01112 2 T Q ? ? possibly damaging sequence annotation 2.2 deleterious 0.708 0.0816 0.859 0.114 MOD_RES NO ? +1.486 -1.534 -3.020 2 189 20 20 6q21 2 D 1.00 171 0.194 E B 28 0.42 -0.26 ? ? ? 3 3.345 ? ? ? ? ? ? NO 10.866 10.866 79.89 +P01112 2 T R ? P01112 2 T R C G possibly damaging sequence annotation 2.2 deleterious 0.681 0.0843 0.862 0.117 MOD_RES NO ? +1.430 -1.534 -2.964 2 189 20 20 6q21 2 D 1.00 171 0.194 E B 57 0.98 -0.26 ? ? ? 3 3.345 ? ? 1 1 1 -58 NO 24.938 24.938 79.89 +P01112 2 T S ? P01112 2 T S A T benign sequence annotation 2.2 neutral 0.037 0.176 0.945 0.201 MOD_RES NO ? +1.160 -1.534 -2.694 2 189 20 20 6q21 2 D 1.00 171 0.194 E B -27 0.05 -0.26 ? ? ? 3 3.345 ? ? 1 0 0 -57 NO 17.571 17.571 79.89 +P01112 2 T V ? P01112 2 T V ? ? possibly damaging sequence annotation 2.2 deleterious 0.605 0.0917 0.873 0.125 MOD_RES NO ? +1.216 -1.534 -2.750 2 189 20 20 6q21 2 D 1.00 171 0.194 E B 24 0.66 -0.26 ? ? ? 3 3.345 ? ? ? ? ? ? NO 11.823 11.823 79.89 +P01112 2 T W ? P01112 2 T W ? ? probably damaging sequence annotation 2.2 deleterious 1 0.00026 0.00018 0.0109 MOD_RES NO ? +3.773 -1.534 -5.307 2 189 20 20 6q21 2 D 1.00 171 0.194 E B 111 0.69 -0.26 ? ? ? 3 3.345 ? ? ? ? ? ? NO 0.966 ? 79.89 +P01112 2 T Y ? P01112 2 T Y ? ? probably damaging sequence annotation 2.2 deleterious 0.98 0.0405 0.753 0.0679 MOD_RES NO ? +2.634 -1.534 -4.168 2 189 20 20 6q21 2 D 1.00 171 0.194 E B 77 0.43 -0.26 ? ? ? 3 3.345 ? ? ? ? ? ? NO 4.825 ? 79.89 +P01112 3 E A ? P01112 3 E A A C possibly damaging alignment ? deleterious 0.771 0.0758 0.85 0.108 NO NO ? +1.820 -1.312 -3.132 2 196 20 20 6q21 3 D 1.00 171 0.433 E B -50 1.04 0.20 ? ? ? 1 4.266 ? ? 1 1 0 -61 NO 5.976 ? 77.78 +P01112 3 E C ? P01112 3 E C ? ? probably damaging alignment ? deleterious 0.999 0.00574 0.136 0.0192 NO NO ? +3.859 -1.312 -5.171 2 196 20 20 6q21 3 D 1.00 171 0.433 E B -30 1.5 0.20 ? ? ? 1 4.266 ? ? ? ? ? ? NO 1.451 ? 77.78 +P01112 3 E D ? P01112 3 E D A C possibly damaging alignment ? deleterious 0.753 0.0774 0.852 0.11 NO NO ? +1.845 -1.312 -3.157 2 196 20 20 6q21 3 D 1.00 171 0.433 E B -27 0.29 0.20 ? ? ? 1 4.266 ? ? 1 2 0 -62 NO 4.497 ? 77.78 +P01112 3 E F ? P01112 3 E F ? ? probably damaging alignment ? deleterious 0.995 0.0277 0.681 0.0521 NO NO ? +2.934 -1.312 -4.246 2 196 20 20 6q21 3 D 1.00 171 0.433 E B 52 1.62 0.20 ? ? ? 1 4.266 ? ? ? ? ? ? NO 2.748 ? 77.78 +P01112 3 E G ? P01112 3 E G A G benign alignment ? neutral 0.271 0.116 0.909 0.148 NO NO ? +1.207 -1.312 -2.519 2 196 20 20 6q21 3 D 1.00 171 0.433 E B -78 0.75 0.20 ? ? ? 1 4.266 ? ? 0 1 0 -61 NO 38.846 38.846 77.78 +P01112 3 E H ? P01112 3 E H ? ? probably damaging alignment ? deleterious 0.997 0.0167 0.409 0.0357 NO NO ? +3.118 -1.312 -4.430 2 196 20 20 6q21 3 D 1.00 171 0.433 E B 15 0.87 0.20 ? ? ? 1 4.266 ? ? ? ? ? ? NO 1.729 ? 77.78 +P01112 3 E I ? P01112 3 E I ? ? possibly damaging alignment ? deleterious 0.931 0.0577 0.805 0.0885 NO NO ? +2.469 -1.312 -3.781 2 196 20 20 6q21 3 D 1.00 171 0.433 E B 29 1.52 0.20 ? ? ? 1 4.266 ? ? ? ? ? ? NO 12.770 ? 77.78 +P01112 3 E K ? P01112 3 E K G A benign alignment ? neutral 0.172 0.13 0.919 0.161 NO NO ? +1.004 -1.312 -2.316 2 196 20 20 6q21 3 D 1.00 171 0.433 E B 30 1.3 0.20 ? ? ? 1 4.266 ? ? 0 0 0 -60 NO 20.084 20.084 77.78 +P01112 3 E L ? P01112 3 E L ? ? possibly damaging alignment ? deleterious 0.931 0.0577 0.805 0.0885 NO NO ? +2.068 -1.312 -3.380 2 196 20 20 6q21 3 D 1.00 171 0.433 E B 29 1.59 0.20 ? ? ? 1 4.266 ? ? ? ? ? ? NO 10.110 ? 77.78 +P01112 3 E M ? P01112 3 E M ? ? benign alignment ? neutral 0.41 0.103 0.894 0.136 NO NO ? +1.775 -1.312 -3.087 2 196 20 20 6q21 3 D 1.00 171 0.433 E B 25 1.59 0.20 ? ? ? 1 4.266 ? ? ? ? ? ? NO 7.113 7.113 77.78 +P01112 3 E N ? P01112 3 E N ? ? benign alignment ? neutral 0.204 0.124 0.915 0.156 NO NO ? +1.374 -1.312 -2.686 2 196 20 20 6q21 3 D 1.00 171 0.433 E B -24 0.43 0.20 ? ? ? 1 4.266 ? ? ? ? ? ? NO 17.093 17.093 77.78 +P01112 3 E P ? P01112 3 E P ? ? possibly damaging alignment ? deleterious 0.891 0.0637 0.821 0.0952 NO NO ? +2.498 -1.312 -3.810 2 196 20 20 6q21 3 D 1.00 171 0.433 E B -26 0.52 0.20 ? ? ? 1 4.266 ? ? ? ? ? ? NO 1.966 ? 77.78 +P01112 3 E Q ? P01112 3 E Q G C probably damaging alignment ? deleterious 0.969 0.045 0.77 0.0734 NO NO ? +2.212 -1.312 -3.524 2 196 20 20 6q21 3 D 1.00 171 0.433 E B 6 0.4 0.20 ? ? ? 1 4.266 ? ? 1 0 0 -60 NO 3.860 ? 77.78 +P01112 3 E R ? P01112 3 E R ? ? probably damaging alignment ? deleterious 0.967 0.046 0.773 0.0746 NO NO ? +2.270 -1.312 -3.582 2 196 20 20 6q21 3 D 1.00 171 0.433 E B 35 0.16 0.20 ? ? ? 1 4.266 ? ? ? ? ? ? NO 7.770 ? 77.78 +P01112 3 E S ? P01112 3 E S ? ? probably damaging alignment ? deleterious 0.969 0.045 0.77 0.0734 NO NO ? +1.958 -1.312 -3.270 2 196 20 20 6q21 3 D 1.00 171 0.433 E B -49 0.77 0.20 ? ? ? 1 4.266 ? ? ? ? ? ? NO 3.940 ? 77.78 +P01112 3 E T ? P01112 3 E T ? ? probably damaging alignment ? deleterious 0.977 0.0424 0.758 0.0704 NO NO ? +2.164 -1.312 -3.476 2 196 20 20 6q21 3 D 1.00 171 0.433 E B -22 0.82 0.20 ? ? ? 1 4.266 ? ? ? ? ? ? NO 3.883 ? 77.78 +P01112 3 E V ? P01112 3 E V A T benign alignment ? neutral 0.064 0.159 0.937 0.187 NO NO ? +1.364 -1.312 -2.676 2 196 20 20 6q21 3 D 1.00 171 0.433 E B 2 1.48 0.20 ? ? ? 1 4.266 ? ? 1 1 0 -61 NO 20.940 20.940 77.78 +P01112 3 E W ? P01112 3 E W ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +4.038 -1.312 -5.350 2 196 20 20 6q21 3 D 1.00 171 0.433 E B 89 1.51 0.20 ? ? ? 1 4.266 ? ? ? ? ? ? NO 0.419 ? 77.78 +P01112 3 E Y ? P01112 3 E Y ? ? probably damaging alignment ? deleterious 0.999 0.00574 0.136 0.0192 NO NO ? +2.905 -1.312 -4.217 2 196 20 20 6q21 3 D 1.00 171 0.433 E B 55 1.25 0.20 ? ? ? 1 4.266 ? ? ? ? ? ? NO 1.652 ? 77.78 +P01112 4 Y A ? P01112 4 Y A ? ? probably damaging structure 1.1.3 deleterious 0.982 0.0393 0.748 0.0664 NO NO ? +1.527 -1.025 -2.552 2 212 20 20 6q21 4 D 1.00 171 0.028 E B -105 0.21 -0.43 ? ? ? ? ? ? ? ? ? ? ? NO 19.771 19.771 68.25 +P01112 4 Y C ? P01112 4 Y C A G probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.857 -1.025 -4.882 2 212 20 20 6q21 4 D 1.00 171 0.028 E B -85 0.25 -0.43 ? ? ? ? ? ? ? 0 1 0 -64 NO 1.463 ? 68.25 +P01112 4 Y D ? P01112 4 Y D T G probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.942 -1.025 -3.967 2 212 20 20 6q21 4 D 1.00 171 0.028 E B -82 0.96 -0.43 ? ? ? ? ? ? ? 1 0 0 -63 NO 1.993 ? 68.25 +P01112 4 Y E ? P01112 4 Y E ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.725 -1.025 -3.750 2 212 20 20 6q21 4 D 1.00 171 0.028 E B -55 1.25 -0.43 ? ? ? ? ? ? ? ? ? ? ? NO 2.748 ? 68.25 +P01112 4 Y F ? P01112 4 Y F A T possibly damaging alignment ? deleterious 0.84 0.0683 0.836 0.0997 NO NO ? +1.062 -1.025 -2.087 2 212 20 20 6q21 4 D 1.00 171 0.028 E B -3 0.37 -0.43 ? ? ? ? ? ? ? 1 1 0 -64 NO 24.065 24.065 68.25 +P01112 4 Y G ? P01112 4 Y G ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.544 -1.025 -3.569 2 212 20 20 6q21 4 D 1.00 171 0.028 E B -133 0.5 -0.43 ? ? ? ? ? ? ? ? ? ? ? NO 5.349 ? 68.25 +P01112 4 Y H ? P01112 4 Y H T C probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.984 -1.025 -4.009 2 212 20 20 6q21 4 D 1.00 171 0.028 E B -40 0.38 -0.43 ? ? ? ? ? ? ? 0 0 0 -63 NO 1.067 ? 68.25 +P01112 4 Y I ? P01112 4 Y I ? ? probably damaging alignment ? deleterious 0.998 0.0112 0.273 0.0274 NO NO ? +2.561 -1.025 -3.586 2 212 20 20 6q21 4 D 1.00 171 0.028 E B -26 0.27 -0.43 ? ? ? ? ? ? ? ? ? ? ? NO 4.010 ? 68.25 +P01112 4 Y K ? P01112 4 Y K ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.742 -1.025 -3.767 2 212 20 20 6q21 4 D 1.00 171 0.028 E B -25 2.55 -0.43 ? ? ? ? ? ? ? ? ? ? ? NO 3.078 ? 68.25 +P01112 4 Y L ? P01112 4 Y L ? ? probably damaging alignment ? deleterious 0.996 0.0222 0.545 0.0439 NO NO ? +2.133 -1.025 -3.158 2 212 20 20 6q21 4 D 1.00 171 0.028 E B -26 0.34 -0.43 ? ? ? ? ? ? ? ? ? ? ? NO 7.130 ? 68.25 +P01112 4 Y M ? P01112 4 Y M ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.480 -1.025 -4.505 2 212 20 20 6q21 4 D 1.00 171 0.028 E B -30 0.34 -0.43 ? ? ? ? ? ? ? ? ? ? ? NO 1.567 ? 68.25 +P01112 4 Y N ? P01112 4 Y N T A probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.982 -1.025 -4.007 2 212 20 20 6q21 4 D 1.00 171 0.028 E B -79 0.82 -0.43 ? ? ? ? ? ? ? 1 0 0 -63 NO 1.793 ? 68.25 +P01112 4 Y P ? P01112 4 Y P ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.135 -1.025 -4.160 2 212 20 20 6q21 4 D 1.00 171 0.028 E B -81 0.73 -0.43 ? ? ? ? ? ? ? ? ? ? ? NO 1.984 ? 68.25 +P01112 4 Y Q ? P01112 4 Y Q ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.015 -1.025 -4.040 2 212 20 20 6q21 4 D 1.00 171 0.028 E B -49 0.85 -0.43 ? ? ? ? ? ? ? ? ? ? ? NO 1.770 ? 68.25 +P01112 4 Y R ? P01112 4 Y R ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.993 -1.025 -4.018 2 212 20 20 6q21 4 D 1.00 171 0.028 E B -20 1.41 -0.43 ? ? ? ? ? ? ? ? ? ? ? NO 2.158 ? 68.25 +P01112 4 Y S ? P01112 4 Y S A C probably damaging alignment ? deleterious 0.999 0.00574 0.136 0.0192 NO NO ? +2.571 -1.025 -3.596 2 212 20 20 6q21 4 D 1.00 171 0.028 E B -104 0.48 -0.43 ? ? ? ? ? ? ? 1 1 0 -64 NO 5.750 ? 68.25 +P01112 4 Y T ? P01112 4 Y T ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.641 -1.025 -3.666 2 212 20 20 6q21 4 D 1.00 171 0.028 E B -77 0.43 -0.43 ? ? ? ? ? ? ? ? ? ? ? NO 3.419 ? 68.25 +P01112 4 Y V ? P01112 4 Y V ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.327 -1.025 -3.352 2 212 20 20 6q21 4 D 1.00 171 0.028 E B -53 0.23 -0.43 ? ? ? ? ? ? ? ? ? ? ? NO 4.661 ? 68.25 +P01112 4 Y W ? P01112 4 Y W ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.349 -1.025 -4.374 2 212 20 20 6q21 4 D 1.00 171 0.028 E B 34 0.26 -0.43 ? ? ? ? ? ? ? ? ? ? ? NO 1.118 ? 68.25 +P01112 5 K A ? P01112 5 K A ? ? probably damaging alignment ? deleterious 0.998 0.0112 0.273 0.0274 NO NO ? +2.182 -0.976 -3.158 2 212 20 20 6q21 5 D 1.00 171 0.467 E B -80 2.34 -0.02 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 3.104 ? 68.25 +P01112 5 K C ? P01112 5 K C ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +4.172 -0.976 -5.148 2 212 20 20 6q21 5 D 1.00 171 0.467 E B -60 2.8 -0.02 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 0.521 ? 68.25 +P01112 5 K D ? P01112 5 K D ? ? probably damaging alignment ? deleterious 0.998 0.0112 0.273 0.0274 NO NO ? +2.528 -0.976 -3.504 2 212 20 20 6q21 5 D 1.00 171 0.467 E B -57 1.59 -0.02 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 4.232 ? 68.25 +P01112 5 K E ? P01112 5 K E A G probably damaging alignment ? deleterious 0.991 0.0326 0.711 0.0584 NO NO ? +2.124 -0.976 -3.100 2 212 20 20 6q21 5 D 1.00 171 0.467 E B -30 1.3 -0.02 ? ? ? ? ? ? ? 0 0 0 -66 PF00071.17 3.562 ? 68.25 +P01112 5 K F ? P01112 5 K F ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.376 -0.976 -4.352 2 212 20 20 6q21 5 D 1.00 171 0.467 E B 22 2.92 -0.02 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.232 ? 68.25 +P01112 5 K G ? P01112 5 K G ? ? probably damaging alignment ? deleterious 0.998 0.0112 0.273 0.0274 NO NO ? +2.389 -0.976 -3.365 2 212 20 20 6q21 5 D 1.00 171 0.467 E B -108 2.05 -0.02 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 3.253 ? 68.25 +P01112 5 K H ? P01112 5 K H ? ? probably damaging alignment ? deleterious 0.999 0.00574 0.136 0.0192 NO NO ? +3.451 -0.976 -4.427 2 212 20 20 6q21 5 D 1.00 171 0.467 E B -15 2.17 -0.02 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.641 ? 68.25 +P01112 5 K I ? P01112 5 K I ? ? probably damaging alignment ? deleterious 0.991 0.0326 0.711 0.0584 NO NO ? +3.095 -0.976 -4.071 2 212 20 20 6q21 5 D 1.00 171 0.467 E B -1 2.82 -0.02 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.644 ? 68.25 +P01112 5 K L ? P01112 5 K L ? ? possibly damaging alignment ? deleterious 0.935 0.057 0.803 0.0878 NO NO ? +2.462 -0.976 -3.438 2 212 20 20 6q21 5 D 1.00 171 0.467 E B -1 2.89 -0.02 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 3.199 ? 68.25 +P01112 5 K M ? P01112 5 K M A T probably damaging alignment ? deleterious 0.999 0.00574 0.136 0.0192 NO NO ? +3.584 -0.976 -4.560 2 212 20 20 6q21 5 D 1.00 171 0.467 E B -5 2.89 -0.02 ? ? ? ? ? ? ? 1 1 0 -67 PF00071.17 1.062 ? 68.25 +P01112 5 K N ? P01112 5 K N G C possibly damaging alignment ? deleterious 0.948 0.0532 0.793 0.0833 NO NO ? +1.629 -0.976 -2.605 2 212 20 20 6q21 5 D 1.00 171 0.467 E B -54 1.73 -0.02 ? ? ? ? ? ? ? 1 2 0 -68 PF00071.17 16.087 16.087 68.25 +P01112 5 K P ? P01112 5 K P ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.789 -0.976 -3.765 2 212 20 20 6q21 5 D 1.00 171 0.467 E B -56 1.82 -0.02 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.267 ? 68.25 +P01112 5 K Q ? P01112 5 K Q A C probably damaging alignment ? deleterious 0.978 0.0417 0.756 0.0695 NO NO ? +2.553 -0.976 -3.529 2 212 20 20 6q21 5 D 1.00 171 0.467 E B -24 1.7 -0.02 ? ? ? ? ? ? ? 1 0 0 -66 PF00071.17 3.287 ? 68.25 +P01112 5 K R ? P01112 5 K R A G benign alignment ? neutral 0.244 0.119 0.912 0.151 NO NO ? +1.292 -0.976 -2.268 2 212 20 20 6q21 5 D 1.00 171 0.467 E B 5 1.14 -0.02 ? ? ? ? ? ? ? 0 1 0 -67 PF00071.17 23.482 23.482 68.25 +P01112 5 K S ? P01112 5 K S ? ? probably damaging alignment ? deleterious 0.998 0.0112 0.273 0.0274 NO NO ? +2.250 -0.976 -3.226 2 212 20 20 6q21 5 D 1.00 171 0.467 E B -79 2.07 -0.02 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 3.580 ? 68.25 +P01112 5 K T ? P01112 5 K T A C probably damaging alignment ? deleterious 0.996 0.0222 0.545 0.0439 NO NO ? +2.482 -0.976 -3.458 2 212 20 20 6q21 5 D 1.00 171 0.467 E B -52 2.12 -0.02 ? ? ? ? ? ? ? 1 1 2 -67 PF00071.17 2.544 ? 68.25 +P01112 5 K V ? P01112 5 K V ? ? probably damaging alignment ? deleterious 0.975 0.0436 0.762 0.072 NO NO ? +2.663 -0.976 -3.639 2 212 20 20 6q21 5 D 1.00 171 0.467 E B -28 2.78 -0.02 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.091 ? 68.25 +P01112 5 K W ? P01112 5 K W ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +4.426 -0.976 -5.402 2 212 20 20 6q21 5 D 1.00 171 0.467 E B 59 2.81 -0.02 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 0.351 ? 68.25 +P01112 5 K Y ? P01112 5 K Y ? ? probably damaging alignment ? deleterious 0.998 0.0112 0.273 0.0274 NO NO ? +3.247 -0.976 -4.223 2 212 20 20 6q21 5 D 1.00 171 0.467 E B 25 2.55 -0.02 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.225 ? 68.25 +P01112 6 L A ? P01112 6 L A ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.111 -1.073 -3.184 2 212 20 20 6q21 6 D 1.00 171 0.007 E B -79 0.55 -0.96 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 3.420 ? 69.84 +P01112 6 L C ? P01112 6 L C ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.690 -1.073 -4.763 2 212 20 20 6q21 6 D 1.00 171 0.007 E B -59 0.09 -0.96 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.101 ? 69.84 +P01112 6 L D ? P01112 6 L D ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.087 -1.073 -4.160 2 212 20 20 6q21 6 D 1.00 171 0.007 E B -56 1.3 -0.96 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.241 ? 69.84 +P01112 6 L E ? P01112 6 L E ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.879 -1.073 -3.952 2 212 20 20 6q21 6 D 1.00 171 0.007 E B -29 1.59 -0.96 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.697 ? 69.84 +P01112 6 L F ? P01112 6 L F ? ? probably damaging alignment ? deleterious 0.979 0.0411 0.755 0.0687 NO NO ? +1.738 -1.073 -2.811 2 212 20 20 6q21 6 D 1.00 171 0.007 E B 23 0.03 -0.96 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 26.921 26.921 69.84 +P01112 6 L G ? P01112 6 L G ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.778 -1.073 -3.851 2 212 20 20 6q21 6 D 1.00 171 0.007 E B -107 0.84 -0.96 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.831 ? 69.84 +P01112 6 L H ? P01112 6 L H ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.870 -1.073 -4.943 2 212 20 20 6q21 6 D 1.00 171 0.007 E B -14 0.72 -0.96 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.194 ? 69.84 +P01112 6 L I ? P01112 6 L I ? ? possibly damaging alignment ? deleterious 0.86 0.0666 0.831 0.098 NO NO ? +1.246 -1.073 -2.319 2 212 20 20 6q21 6 D 1.00 171 0.007 E B 0 0.07 -0.96 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 18.533 18.533 69.84 +P01112 6 L K ? P01112 6 L K ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.728 -1.073 -3.801 2 212 20 20 6q21 6 D 1.00 171 0.007 E B 1 2.89 -0.96 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.270 ? 69.84 +P01112 6 L M ? P01112 6 L M C A probably damaging alignment ? deleterious 0.993 0.0301 0.696 0.0553 NO NO ? +1.624 -1.073 -2.697 2 212 20 20 6q21 6 D 1.00 171 0.007 E B -4 0 -0.96 ? ? ? ? ? ? ? 1 0 0 -69 PF00071.17 10.113 10.113 69.84 +P01112 6 L N ? P01112 6 L N ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.131 -1.073 -4.204 2 212 20 20 6q21 6 D 1.00 171 0.007 E B -53 1.16 -0.96 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.323 ? 69.84 +P01112 6 L P ? P01112 6 L P T C probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.108 -1.073 -4.181 2 212 20 20 6q21 6 D 1.00 171 0.007 E B -55 1.07 -0.96 ? ? ? ? ? ? ? 0 1 2 -70 PF00071.17 1.020 ? 69.84 +P01112 6 L Q ? P01112 6 L Q T A probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.134 -1.073 -4.207 2 212 20 20 6q21 6 D 1.00 171 0.007 E B -23 1.19 -0.96 ? ? ? ? ? ? ? 1 1 0 -70 PF00071.17 1.849 ? 69.84 +P01112 6 L R ? P01112 6 L R T G probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.996 -1.073 -4.069 2 212 20 20 6q21 6 D 1.00 171 0.007 E B 6 1.75 -0.96 ? ? ? ? ? ? ? 1 1 2 -70 PF00071.17 2.006 ? 69.84 +P01112 6 L S ? P01112 6 L S ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.618 -1.073 -3.691 2 212 20 20 6q21 6 D 1.00 171 0.007 E B -78 0.82 -0.96 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.139 ? 69.84 +P01112 6 L T ? P01112 6 L T ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.454 -1.073 -3.527 2 212 20 20 6q21 6 D 1.00 171 0.007 E B -51 0.77 -0.96 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.709 ? 69.84 +P01112 6 L V ? P01112 6 L V C G possibly damaging alignment ? deleterious 0.947 0.0535 0.794 0.0836 NO NO ? +1.351 -1.073 -2.424 2 212 20 20 6q21 6 D 1.00 171 0.007 E B -27 0.11 -0.96 ? ? ? ? ? ? ? 1 0 0 -69 PF00071.17 13.248 13.248 69.84 +P01112 6 L W ? P01112 6 L W ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +4.071 -1.073 -5.144 2 212 20 20 6q21 6 D 1.00 171 0.007 E B 60 0.08 -0.96 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.251 ? 69.84 +P01112 6 L Y ? P01112 6 L Y ? ? probably damaging alignment ? deleterious 0.999 0.00574 0.136 0.0192 NO NO ? +2.866 -1.073 -3.939 2 212 20 20 6q21 6 D 1.00 171 0.007 E B 26 0.34 -0.96 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 6.244 ? 69.84 +P01112 7 V A ? P01112 7 V A T C probably damaging alignment ? deleterious 0.992 0.0314 0.704 0.0568 NO NO ? +0.732 -1.040 -1.772 2 212 20 20 6q21 7 D 1.00 171 0.042 E B -52 0.44 -0.70 ? ? ? ? ? ? ? 0 1 2 -73 PF00071.17 15.939 15.939 55.03 +P01112 7 V C ? P01112 7 V C ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.575 -1.040 -4.615 2 212 20 20 6q21 7 D 1.00 171 0.042 E B -32 0.02 -0.70 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.179 ? 55.03 +P01112 7 V D ? P01112 7 V D ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.857 -1.040 -3.897 2 212 20 20 6q21 7 D 1.00 171 0.042 E B -29 1.19 -0.70 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.607 ? 55.03 +P01112 7 V E ? P01112 7 V E T A probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.603 -1.040 -3.643 2 212 20 20 6q21 7 D 1.00 171 0.042 E B -2 1.48 -0.70 ? ? ? ? ? ? ? 1 1 0 -73 PF00071.17 2.215 ? 55.03 +P01112 7 V F ? P01112 7 V F ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.899 -1.040 -3.939 2 212 20 20 6q21 7 D 1.00 171 0.042 E B 50 0.14 -0.70 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.213 ? 55.03 +P01112 7 V G ? P01112 7 V G T G probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.360 -1.040 -3.400 2 212 20 20 6q21 7 D 1.00 171 0.042 E B -80 0.73 -0.70 ? ? ? ? ? ? ? 1 1 0 -73 PF00071.17 4.312 ? 55.03 +P01112 7 V H ? P01112 7 V H ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.843 -1.040 -4.883 2 212 20 20 6q21 7 D 1.00 171 0.042 E B 13 0.61 -0.70 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 0.821 ? 55.03 +P01112 7 V I ? P01112 7 V I ? ? probably damaging alignment ? deleterious 0.999 0.00574 0.136 0.0192 NO NO ? +1.833 -1.040 -2.873 2 212 20 20 6q21 7 D 1.00 171 0.042 E B 27 0.04 -0.70 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.364 ? 55.03 +P01112 7 V K ? P01112 7 V K ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.620 -1.040 -3.660 2 212 20 20 6q21 7 D 1.00 171 0.042 E B 28 2.78 -0.70 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.481 ? 55.03 +P01112 7 V L ? P01112 7 V L G C probably damaging alignment ? deleterious 0.999 0.00574 0.136 0.0192 NO NO ? +1.786 -1.040 -2.826 2 212 20 20 6q21 7 D 1.00 171 0.042 E B 27 0.11 -0.70 ? ? ? ? ? ? ? 1 0 0 -72 PF00071.17 3.276 ? 55.03 +P01112 7 V M ? P01112 7 V M G A probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.133 -1.040 -4.173 2 212 20 20 6q21 7 D 1.00 171 0.042 E B 23 0.11 -0.70 ? ? ? ? ? ? ? 0 0 0 -72 PF00071.17 0.994 ? 55.03 +P01112 7 V N ? P01112 7 V N ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.061 -1.040 -4.101 2 212 20 20 6q21 7 D 1.00 171 0.042 E B -26 1.05 -0.70 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.445 ? 55.03 +P01112 7 V P ? P01112 7 V P ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.818 -1.040 -3.858 2 212 20 20 6q21 7 D 1.00 171 0.042 E B -28 0.96 -0.70 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.599 ? 55.03 +P01112 7 V Q ? P01112 7 V Q ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.062 -1.040 -4.102 2 212 20 20 6q21 7 D 1.00 171 0.042 E B 4 1.08 -0.70 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.427 ? 55.03 +P01112 7 V R ? P01112 7 V R ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.021 -1.040 -4.061 2 212 20 20 6q21 7 D 1.00 171 0.042 E B 33 1.64 -0.70 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.740 ? 55.03 +P01112 7 V S ? P01112 7 V S ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.387 -1.040 -3.427 2 212 20 20 6q21 7 D 1.00 171 0.042 E B -51 0.71 -0.70 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 4.636 ? 55.03 +P01112 7 V T ? P01112 7 V T ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.199 -1.040 -3.239 2 212 20 20 6q21 7 D 1.00 171 0.042 E B -24 0.66 -0.70 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.757 ? 55.03 +P01112 7 V W ? P01112 7 V W ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +4.325 -1.040 -5.365 2 212 20 20 6q21 7 D 1.00 171 0.042 E B 87 0.03 -0.70 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 0.299 ? 55.03 +P01112 7 V Y ? P01112 7 V Y ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.994 -1.040 -4.034 2 212 20 20 6q21 7 D 1.00 171 0.042 E B 53 0.23 -0.70 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 0.964 ? 55.03 +P01112 8 V A ? P01112 8 V A T C probably damaging alignment ? deleterious 0.998 0.0112 0.273 0.0274 NO NO ? +1.859 -1.142 -3.001 2 212 20 20 6q21 8 D 1.00 171 0.000 E B -52 0.44 -0.88 ? ? ? ? ? ? ? 0 1 2 -76 PF00071.17 4.192 ? 66.67 +P01112 8 V C ? P01112 8 V C ? ? probably damaging alignment ? deleterious 0.962 0.0478 0.779 0.0767 NO NO ? +1.880 -1.142 -3.022 2 212 20 20 6q21 8 D 1.00 171 0.000 E B -32 0.02 -0.88 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 31.453 31.453 66.67 +P01112 8 V D ? P01112 8 V D ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.880 -1.142 -4.022 2 212 20 20 6q21 8 D 1.00 171 0.000 E B -29 1.19 -0.88 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.212 ? 66.67 +P01112 8 V E ? P01112 8 V E T A probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.686 -1.142 -3.828 2 212 20 20 6q21 8 D 1.00 171 0.000 E B -2 1.48 -0.88 ? ? ? ? ? ? ? 1 1 0 -76 PF00071.17 1.251 ? 66.67 +P01112 8 V F ? P01112 8 V F ? ? probably damaging alignment ? deleterious 0.999 0.00574 0.136 0.0192 NO NO ? +2.728 -1.142 -3.870 2 212 20 20 6q21 8 D 1.00 171 0.000 E B 50 0.14 -0.88 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.990 ? 66.67 +P01112 8 V G ? P01112 8 V G T G probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.571 -1.142 -3.713 2 212 20 20 6q21 8 D 1.00 171 0.000 E B -80 0.73 -0.88 ? ? ? ? ? ? ? 1 1 0 -76 PF00071.17 2.029 ? 66.67 +P01112 8 V H ? P01112 8 V H ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.827 -1.142 -4.969 2 212 20 20 6q21 8 D 1.00 171 0.000 E B 13 0.61 -0.88 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 0.705 ? 66.67 +P01112 8 V I ? P01112 8 V I ? ? possibly damaging alignment ? deleterious 0.835 0.0687 0.836 0.1 NO NO ? +1.068 -1.142 -2.210 2 212 20 20 6q21 8 D 1.00 171 0.000 E B 27 0.04 -0.88 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 18.102 18.102 66.67 +P01112 8 V K ? P01112 8 V K ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.647 -1.142 -3.789 2 212 20 20 6q21 8 D 1.00 171 0.000 E B 28 2.78 -0.88 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.674 ? 66.67 +P01112 8 V L ? P01112 8 V L G C benign alignment ? neutral 0.257 0.118 0.91 0.149 NO NO ? +1.133 -1.142 -2.275 2 212 20 20 6q21 8 D 1.00 171 0.000 E B 27 0.11 -0.88 ? ? ? ? ? ? ? 1 0 0 -75 PF00071.17 20.266 20.266 66.67 +P01112 8 V M ? P01112 8 V M G A probably damaging alignment ? deleterious 0.989 0.0346 0.723 0.0608 NO NO ? +1.824 -1.142 -2.966 2 212 20 20 6q21 8 D 1.00 171 0.000 E B 23 0.11 -0.88 ? ? ? ? ? ? ? 0 0 0 -75 PF00071.17 7.456 7.456 66.67 +P01112 8 V N ? P01112 8 V N ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.044 -1.142 -4.186 2 212 20 20 6q21 8 D 1.00 171 0.000 E B -26 1.05 -0.88 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.156 ? 66.67 +P01112 8 V P ? P01112 8 V P ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.886 -1.142 -4.028 2 212 20 20 6q21 8 D 1.00 171 0.000 E B -28 0.96 -0.88 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 0.988 ? 66.67 +P01112 8 V Q ? P01112 8 V Q ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.062 -1.142 -4.204 2 212 20 20 6q21 8 D 1.00 171 0.000 E B 4 1.08 -0.88 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.363 ? 66.67 +P01112 8 V R ? P01112 8 V R ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.032 -1.142 -4.174 2 212 20 20 6q21 8 D 1.00 171 0.000 E B 33 1.64 -0.88 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.479 ? 66.67 +P01112 8 V S ? P01112 8 V S ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.511 -1.142 -3.653 2 212 20 20 6q21 8 D 1.00 171 0.000 E B -51 0.71 -0.88 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.750 ? 66.67 +P01112 8 V T ? P01112 8 V T ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.222 -1.142 -3.364 2 212 20 20 6q21 8 D 1.00 171 0.000 E B -24 0.66 -0.88 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.646 ? 66.67 +P01112 8 V W ? P01112 8 V W ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +4.176 -1.142 -5.318 2 212 20 20 6q21 8 D 1.00 171 0.000 E B 87 0.03 -0.88 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 0.399 ? 66.67 +P01112 8 V Y ? P01112 8 V Y ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.898 -1.142 -4.040 2 212 20 20 6q21 8 D 1.00 171 0.000 E B 53 0.23 -0.88 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.357 ? 66.67 +P01112 9 V A ? P01112 9 V A T C probably damaging alignment ? deleterious 0.999 0.00574 0.136 0.0192 NO NO ? +1.841 -1.158 -2.999 2 212 20 20 6q21 9 D 1.00 171 0.000 E B -52 0.44 -0.63 ? ? ? ? ? ? ? 0 1 2 -79 PF00071.17 3.067 ? 57.14 +P01112 9 V C ? P01112 9 V C ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.544 -1.158 -4.702 2 212 20 20 6q21 9 D 1.00 171 0.000 E B -32 0.02 -0.63 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 0.862 ? 57.14 +P01112 9 V D ? P01112 9 V D ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.825 -1.158 -3.983 2 212 20 20 6q21 9 D 1.00 171 0.000 E B -29 1.19 -0.63 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.062 ? 57.14 +P01112 9 V E ? P01112 9 V E T A probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.591 -1.158 -3.749 2 212 20 20 6q21 9 D 1.00 171 0.000 E B -2 1.48 -0.63 ? ? ? ? ? ? ? 1 1 0 -79 PF00071.17 1.553 ? 57.14 +P01112 9 V F ? P01112 9 V F ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.655 -1.158 -3.813 2 212 20 20 6q21 9 D 1.00 171 0.000 E B 50 0.14 -0.63 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.721 ? 57.14 +P01112 9 V G ? P01112 9 V G T G probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.509 -1.158 -3.667 2 212 20 20 6q21 9 D 1.00 171 0.000 E B -80 0.73 -0.63 ? ? ? ? ? ? ? 1 1 0 -79 PF00071.17 1.676 ? 57.14 +P01112 9 V H ? P01112 9 V H ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.740 -1.158 -4.898 2 212 20 20 6q21 9 D 1.00 171 0.000 E B 13 0.61 -0.63 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 0.875 ? 57.14 +P01112 9 V I ? P01112 9 V I ? ? possibly damaging alignment ? deleterious 0.935 0.057 0.803 0.0878 NO NO ? +1.193 -1.158 -2.351 2 212 20 20 6q21 9 D 1.00 171 0.000 E B 27 0.04 -0.63 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 13.792 13.792 57.14 +P01112 9 V K ? P01112 9 V K ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.535 -1.158 -3.693 2 212 20 20 6q21 9 D 1.00 171 0.000 E B 28 2.78 -0.63 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.078 ? 57.14 +P01112 9 V L ? P01112 9 V L G C probably damaging alignment ? deleterious 0.968 0.0455 0.772 0.074 NO NO ? +1.496 -1.158 -2.654 2 212 20 20 6q21 9 D 1.00 171 0.000 E B 27 0.11 -0.63 ? ? ? ? ? ? ? 1 0 0 -78 PF00071.17 11.272 ? 57.14 +P01112 9 V M ? P01112 9 V M G A probably damaging alignment ? deleterious 0.979 0.0411 0.755 0.0687 NO NO ? +0.860 -1.158 -2.018 2 212 20 20 6q21 9 D 1.00 171 0.000 E B 23 0.11 -0.63 ? ? ? ? ? ? ? 0 0 0 -78 PF00071.17 9.256 9.256 57.14 +P01112 9 V N ? P01112 9 V N ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.958 -1.158 -4.116 2 212 20 20 6q21 9 D 1.00 171 0.000 E B -26 1.05 -0.63 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.211 ? 57.14 +P01112 9 V P ? P01112 9 V P ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.806 -1.158 -3.964 2 212 20 20 6q21 9 D 1.00 171 0.000 E B -28 0.96 -0.63 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 0.933 ? 57.14 +P01112 9 V Q ? P01112 9 V Q ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.892 -1.158 -4.050 2 212 20 20 6q21 9 D 1.00 171 0.000 E B 4 1.08 -0.63 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.692 ? 57.14 +P01112 9 V R ? P01112 9 V R ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.910 -1.158 -4.068 2 212 20 20 6q21 9 D 1.00 171 0.000 E B 33 1.64 -0.63 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.836 ? 57.14 +P01112 9 V S ? P01112 9 V S ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.445 -1.158 -3.603 2 212 20 20 6q21 9 D 1.00 171 0.000 E B -51 0.71 -0.63 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.957 ? 57.14 +P01112 9 V T ? P01112 9 V T ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.185 -1.158 -3.343 2 212 20 20 6q21 9 D 1.00 171 0.000 E B -24 0.66 -0.63 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.308 ? 57.14 +P01112 9 V W ? P01112 9 V W ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +4.074 -1.158 -5.232 2 212 20 20 6q21 9 D 1.00 171 0.000 E B 87 0.03 -0.63 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 0.454 ? 57.14 +P01112 9 V Y ? P01112 9 V Y ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.844 -1.158 -4.002 2 212 20 20 6q21 9 D 1.00 171 0.000 E B 53 0.23 -0.63 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.307 ? 57.14 +P01112 10 G A ? P01112 10 G A G C probably damaging alignment ? deleterious 0.999 0.00574 0.136 0.0192 NO NO ? +1.550 -0.707 -2.257 2 212 20 20 6q21 10 D 1.00 171 0.000 E b 28 0.29 -0.45 ? ? ? ? ? ? ? 1 1 0 -82 PF00071.17 18.851 18.851 65.08 +P01112 10 G C ? P01112 10 G C G T probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +4.302 -0.707 -5.009 2 212 20 20 6q21 10 D 1.00 171 0.000 E b 48 0.75 -0.45 ? ? ? ? ? ? ? 1 0 0 -81 PF00071.17 1.395 ? 65.08 +P01112 10 G D ? P01112 10 G D G A probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.811 -0.707 -3.518 2 212 20 20 6q21 10 D 1.00 171 0.000 E b 51 0.46 -0.45 ? ? ? ? ? ? ? 0 1 0 -82 PF00071.17 1.901 ? 65.08 +P01112 10 G E ? P01112 10 G E ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.955 -0.707 -3.662 2 212 20 20 6q21 10 D 1.00 171 0.000 E b 78 0.75 -0.45 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.620 ? 65.08 +P01112 10 G F ? P01112 10 G F ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.583 -0.707 -4.290 2 212 20 20 6q21 10 D 1.00 171 0.000 E b 130 0.87 -0.45 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.435 ? 65.08 +P01112 10 G H ? P01112 10 G H ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.999 -0.707 -4.706 2 212 20 20 6q21 10 D 1.00 171 0.000 E b 93 0.12 -0.45 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 0.971 ? 65.08 +P01112 10 G I ? P01112 10 G I ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.450 -0.707 -4.157 2 212 20 20 6q21 10 D 1.00 171 0.000 E b 107 0.77 -0.45 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.796 ? 65.08 +P01112 10 G K ? P01112 10 G K ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.972 -0.707 -3.679 2 212 20 20 6q21 10 D 1.00 171 0.000 E b 108 2.05 -0.45 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.935 ? 65.08 +P01112 10 G L ? P01112 10 G L ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.023 -0.707 -3.730 2 212 20 20 6q21 10 D 1.00 171 0.000 E b 107 0.84 -0.45 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 3.875 ? 65.08 +P01112 10 G M ? P01112 10 G M ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +4.186 -0.707 -4.893 2 212 20 20 6q21 10 D 1.00 171 0.000 E b 103 0.84 -0.45 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.176 ? 65.08 +P01112 10 G N ? P01112 10 G N ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.809 -0.707 -3.516 2 212 20 20 6q21 10 D 1.00 171 0.000 E b 54 0.32 -0.45 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.709 ? 65.08 +P01112 10 G P ? P01112 10 G P ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.170 -0.707 -3.877 2 212 20 20 6q21 10 D 1.00 171 0.000 E b 52 0.23 -0.45 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.891 ? 65.08 +P01112 10 G Q ? P01112 10 G Q ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.415 -0.707 -4.122 2 212 20 20 6q21 10 D 1.00 171 0.000 E b 84 0.35 -0.45 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.687 ? 65.08 +P01112 10 G R ? P01112 10 G R G C probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.223 -0.707 -3.930 2 212 20 20 6q21 10 D 1.00 171 0.000 E b 113 0.91 -0.45 ? ? ? ? ? ? ? 1 0 2 -81 PF00071.17 2.058 ? 65.08 +P01112 10 G S ? P01112 10 G S G A probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.451 -0.707 -3.158 2 212 20 20 6q21 10 D 1.00 171 0.000 E b 29 0.02 -0.45 ? ? ? ? ? ? ? 0 0 0 -81 PF00071.17 5.483 ? 65.08 +P01112 10 G T ? P01112 10 G T ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.903 -0.707 -3.610 2 212 20 20 6q21 10 D 1.00 171 0.000 E b 56 0.07 -0.45 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 3.260 ? 65.08 +P01112 10 G V ? P01112 10 G V G T probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.968 -0.707 -3.675 2 212 20 20 6q21 10 D 1.00 171 0.000 E b 80 0.73 -0.45 ? ? ? ? ? ? ? 1 1 0 -82 PF00071.17 4.444 ? 65.08 +P01112 10 G W ? P01112 10 G W ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +4.439 -0.707 -5.146 2 212 20 20 6q21 10 D 1.00 171 0.000 E b 167 0.76 -0.45 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 0.353 ? 65.08 +P01112 10 G Y ? P01112 10 G Y ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.678 -0.707 -4.385 2 212 20 20 6q21 10 D 1.00 171 0.000 E b 133 0.5 -0.45 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.140 ? 65.08 +P01112 11 A C ? P01112 11 A C ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.278 -1.576 -4.854 2 212 20 20 6q21 11 D 1.00 171 0.097 S B 20 0.46 -0.27 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.306 ? 78.84 +P01112 11 A D ? P01112 11 A D C A benign structure 1.1.1 neutral 0.271 0.116 0.909 0.148 NO NO ? +0.998 -1.576 -2.574 2 212 20 20 6q21 11 D 1.00 171 0.097 S B 23 0.75 -0.27 ? ? ? ? ? ? ? 1 1 0 +80 PF00071.17 31.276 31.276 78.84 +P01112 11 A E ? P01112 11 A E ? ? probably damaging alignment ? deleterious 0.986 0.0368 0.736 0.0634 NO NO ? +1.939 -1.576 -3.515 2 212 20 20 6q21 11 D 1.00 171 0.097 S B 50 1.04 -0.27 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 7.227 ? 78.84 +P01112 11 A F ? P01112 11 A F ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.751 -1.576 -4.327 2 212 20 20 6q21 11 D 1.00 171 0.097 S B 102 0.58 -0.27 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.632 ? 78.84 +P01112 11 A G ? P01112 11 A G C G benign alignment ? neutral 0.007 0.246 0.965 0.257 NO NO ? +0.466 -1.576 -2.042 2 212 20 20 6q21 11 D 1.00 171 0.097 S B -28 0.29 -0.27 ? ? ? ? ? ? ? 1 1 0 +80 PF00071.17 36.149 36.149 78.84 +P01112 11 A H ? P01112 11 A H ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.213 -1.576 -4.789 2 212 20 20 6q21 11 D 1.00 171 0.097 S B 65 0.17 -0.27 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.402 ? 78.84 +P01112 11 A I ? P01112 11 A I ? ? probably damaging alignment ? deleterious 0.997 0.0167 0.409 0.0357 NO NO ? +2.339 -1.576 -3.915 2 212 20 20 6q21 11 D 1.00 171 0.097 S B 79 0.48 -0.27 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 3.783 ? 78.84 +P01112 11 A K ? P01112 11 A K ? ? probably damaging alignment ? deleterious 0.997 0.0167 0.409 0.0357 NO NO ? +2.046 -1.576 -3.622 2 212 20 20 6q21 11 D 1.00 171 0.097 S B 80 2.34 -0.27 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 3.595 ? 78.84 +P01112 11 A L ? P01112 11 A L ? ? probably damaging alignment ? deleterious 0.995 0.0277 0.681 0.0521 NO NO ? +1.927 -1.576 -3.503 2 212 20 20 6q21 11 D 1.00 171 0.097 S B 79 0.55 -0.27 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 4.665 ? 78.84 +P01112 11 A M ? P01112 11 A M ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.187 -1.576 -4.763 2 212 20 20 6q21 11 D 1.00 171 0.097 S B 75 0.55 -0.27 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.417 ? 78.84 +P01112 11 A N ? P01112 11 A N ? ? possibly damaging alignment ? deleterious 0.859 0.0667 0.831 0.0981 NO NO ? +2.150 -1.576 -3.726 2 212 20 20 6q21 11 D 1.00 171 0.097 S B 26 0.61 -0.27 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 5.469 ? 78.84 +P01112 11 A P ? P01112 11 A P G C benign alignment ? neutral 0.292 0.114 0.907 0.146 NO NO ? +0.830 -1.576 -2.406 2 212 20 20 6q21 11 D 1.00 171 0.097 S B 24 0.52 -0.27 ? ? ? ? ? ? ? 1 0 1 +81 PF00071.17 32.459 32.459 78.84 +P01112 11 A Q ? P01112 11 A Q ? ? probably damaging alignment ? deleterious 0.999 0.00574 0.136 0.0192 NO NO ? +2.464 -1.576 -4.040 2 212 20 20 6q21 11 D 1.00 171 0.097 S B 56 0.64 -0.27 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.423 ? 78.84 +P01112 11 A R ? P01112 11 A R ? ? probably damaging alignment ? deleterious 0.999 0.00574 0.136 0.0192 NO NO ? +2.369 -1.576 -3.945 2 212 20 20 6q21 11 D 1.00 171 0.097 S B 85 1.2 -0.27 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.499 ? 78.84 +P01112 11 A S ? P01112 11 A S G T benign alignment ? neutral 0.275 0.116 0.908 0.147 NO NO ? +0.877 -1.576 -2.453 2 212 20 20 6q21 11 D 1.00 171 0.097 S B 1 0.27 -0.27 ? ? ? ? ? ? ? 1 0 1 +81 PF00071.17 10.938 10.938 78.84 +P01112 11 A T ? P01112 11 A T G A possibly damaging alignment ? deleterious 0.525 0.0959 0.881 0.128 NO NO ? +0.456 -1.576 -2.032 2 212 20 20 6q21 11 D 1.00 171 0.097 S B 28 0.22 -0.27 ? ? ? ? ? ? ? 0 0 1 +81 PF00071.17 17.565 17.565 78.84 +P01112 11 A V ? P01112 11 A V C T probably damaging alignment ? deleterious 0.982 0.0393 0.748 0.0664 NO NO ? +1.891 -1.576 -3.467 2 212 20 20 6q21 11 D 1.00 171 0.097 S B 52 0.44 -0.27 ? ? ? ? ? ? ? 0 1 0 +80 PF00071.17 5.109 ? 78.84 +P01112 11 A W ? P01112 11 A W ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.859 -1.576 -5.435 2 212 20 20 6q21 11 D 1.00 171 0.097 S B 139 0.47 -0.27 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 0.401 ? 78.84 +P01112 11 A Y ? P01112 11 A Y ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.824 -1.576 -4.400 2 212 20 20 6q21 11 D 1.00 171 0.097 S B 105 0.21 -0.27 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.322 ? 78.84 +P01112 12 G A ? P01112 12 G A G C possibly damaging alignment ? deleterious 0.86 0.0666 0.831 0.098 NO NO ? +1.758 -1.290 -3.048 2 212 20 19 6q21 12 D 1.00 171 0.414 T B 28 0.29 -0.37 ? ? ? ? ? ? ? 1 1 0 +77 PF00071.17 9.018 ? 82.54 +P01112 12 G C ? P01112 12 G C G T possibly damaging alignment ? deleterious 0.525 0.0959 0.881 0.128 NO NO ? +1.133 -1.290 -2.423 2 212 20 19 6q21 12 D 1.00 171 0.414 T B 48 0.75 -0.37 ? ? ? ? ? ? ? 1 0 1 +78 PF00071.17 39.635 39.635 82.54 +P01112 12 G D ? P01112 12 G D G A possibly damaging alignment ? deleterious 0.513 0.0962 0.883 0.129 NO NO ? +1.540 -1.290 -2.830 2 212 20 19 6q21 12 D 1.00 171 0.414 T B 51 0.46 -0.37 ? ? ? ? ? ? ? 0 1 0 +77 PF00071.17 31.696 31.696 82.54 +P01112 12 G E ? P01112 12 G E ? ? probably damaging alignment ? deleterious 0.994 0.0289 0.689 0.0537 NO NO ? +2.414 -1.290 -3.704 2 212 20 19 6q21 12 D 1.00 171 0.414 T B 78 0.75 -0.37 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 7.324 ? 82.54 +P01112 12 G F ? P01112 12 G F ? ? possibly damaging alignment ? deleterious 0.941 0.0556 0.799 0.0862 NO NO ? +1.474 -1.290 -2.764 2 212 20 19 6q21 12 D 1.00 171 0.414 T B 130 0.87 -0.37 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 17.743 17.743 82.54 +P01112 12 G H ? P01112 12 G H ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.479 -1.290 -4.769 2 212 20 19 6q21 12 D 1.00 171 0.414 T B 93 0.12 -0.37 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.895 ? 82.54 +P01112 12 G I ? P01112 12 G I ? ? probably damaging alignment ? deleterious 0.982 0.0393 0.748 0.0664 NO NO ? +2.586 -1.290 -3.876 2 212 20 19 6q21 12 D 1.00 171 0.414 T B 107 0.77 -0.37 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 13.379 ? 82.54 +P01112 12 G K ? P01112 12 G K ? ? probably damaging alignment ? deleterious 0.994 0.0289 0.689 0.0537 NO NO ? +2.426 -1.290 -3.716 2 212 20 19 6q21 12 D 1.00 171 0.414 T B 108 2.05 -0.37 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 9.522 ? 82.54 +P01112 12 G L ? P01112 12 G L ? ? probably damaging alignment ? deleterious 0.994 0.0289 0.689 0.0537 NO NO ? +2.230 -1.290 -3.520 2 212 20 19 6q21 12 D 1.00 171 0.414 T B 107 0.84 -0.37 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 10.592 ? 82.54 +P01112 12 G M ? P01112 12 G M ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.459 -1.290 -4.749 2 212 20 19 6q21 12 D 1.00 171 0.414 T B 103 0.84 -0.37 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.584 ? 82.54 +P01112 12 G N ? P01112 12 G N ? ? probably damaging alignment ? deleterious 0.994 0.0289 0.689 0.0537 NO NO ? +2.434 -1.290 -3.724 2 212 20 19 6q21 12 D 1.00 171 0.414 T B 54 0.32 -0.37 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 5.542 ? 82.54 +P01112 12 G P ? P01112 12 G P ? ? probably damaging alignment ? deleterious 0.999 0.00574 0.136 0.0192 NO NO ? +2.764 -1.290 -4.054 2 212 20 19 6q21 12 D 1.00 171 0.414 T B 52 0.23 -0.37 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.403 ? 82.54 +P01112 12 G Q ? P01112 12 G Q ? ? probably damaging alignment ? deleterious 0.999 0.00574 0.136 0.0192 NO NO ? +2.879 -1.290 -4.169 2 212 20 19 6q21 12 D 1.00 171 0.414 T B 84 0.35 -0.37 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 3.797 ? 82.54 +P01112 12 G R ? P01112 12 G R G C possibly damaging alignment ? deleterious 0.878 0.0649 0.825 0.0963 NO NO ? +1.733 -1.290 -3.023 2 212 20 19 6q21 12 D 1.00 171 0.414 T B 113 0.91 -0.37 ? ? ? ? ? ? ? 1 0 3 +78 PF00071.17 27.123 27.123 82.54 +P01112 12 G S ? P01112 12 G S G A possibly damaging alignment ? deleterious 0.831 0.0691 0.837 0.101 NO NO ? +1.233 -1.290 -2.523 2 212 20 19 6q21 12 D 1.00 171 0.414 T B 29 0.02 -0.37 ? ? ? ? ? ? ? 0 0 1 +78 PF00071.17 18.152 18.152 82.54 +P01112 12 G T ? P01112 12 G T ? ? probably damaging alignment ? deleterious 0.994 0.0289 0.689 0.0537 NO NO ? +2.310 -1.290 -3.600 2 212 20 19 6q21 12 D 1.00 171 0.414 T B 56 0.07 -0.37 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 6.779 ? 82.54 +P01112 12 G V ? P01112 12 G V G T possibly damaging alignment ? deleterious 0.738 0.079 0.854 0.111 NO NO ? +1.572 -1.290 -2.862 2 212 20 19 6q21 12 D 1.00 171 0.414 T B 80 0.73 -0.37 ? ? ? ? ? ? ? 1 1 0 +77 PF00071.17 21.937 21.937 82.54 +P01112 12 G W ? P01112 12 G W ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.928 -1.290 -5.218 2 212 20 19 6q21 12 D 1.00 171 0.414 T B 167 0.76 -0.37 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 0.824 ? 82.54 +P01112 12 G Y ? P01112 12 G Y ? ? probably damaging alignment ? deleterious 0.999 0.00574 0.136 0.0192 NO NO ? +2.899 -1.290 -4.189 2 212 20 19 6q21 12 D 1.00 171 0.414 T B 133 0.5 -0.37 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 4.115 ? 82.54 +P01112 13 G A ? P01112 13 G A G C possibly damaging alignment ? deleterious 0.85 0.0674 0.834 0.0987 NO NO ? +1.780 -1.285 -3.065 2 212 20 20 6q21 13 D 1.00 171 0.701 T l 28 0.29 -1.12 ? ? ? ? ? ? ? 1 1 0 +74 PF00071.17 9.076 ? 83.07 +P01112 13 G C ? P01112 13 G C G T possibly damaging alignment ? deleterious 0.504 0.0966 0.883 0.129 NO NO ? +1.345 -1.285 -2.630 2 212 20 20 6q21 13 D 1.00 171 0.701 T l 48 0.75 -1.12 ? ? ? ? ? ? ? 1 0 1 +75 PF00071.17 24.548 24.548 83.07 +P01112 13 G D ? P01112 13 G D G A benign alignment ? neutral 0.286 0.115 0.907 0.147 NO NO ? +1.269 -1.285 -2.554 2 212 20 20 6q21 13 D 1.00 171 0.701 T l 51 0.46 -1.12 ? ? ? ? ? ? ? 0 1 0 +74 PF00071.17 28.337 28.337 83.07 +P01112 13 G E ? P01112 13 G E ? ? probably damaging alignment ? deleterious 0.993 0.0301 0.696 0.0553 NO NO ? +2.322 -1.285 -3.607 2 212 20 20 6q21 13 D 1.00 171 0.701 T l 78 0.75 -1.12 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 6.548 ? 83.07 +P01112 13 G F ? P01112 13 G F ? ? possibly damaging alignment ? deleterious 0.936 0.0568 0.802 0.0876 NO NO ? +1.747 -1.285 -3.032 2 212 20 20 6q21 13 D 1.00 171 0.701 T l 130 0.87 -1.12 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 18.763 18.763 83.07 +P01112 13 G H ? P01112 13 G H ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.389 -1.285 -4.674 2 212 20 20 6q21 13 D 1.00 171 0.701 T l 93 0.12 -1.12 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.070 ? 83.07 +P01112 13 G I ? P01112 13 G I ? ? probably damaging alignment ? deleterious 0.999 0.00574 0.136 0.0192 NO NO ? +2.752 -1.285 -4.037 2 212 20 20 6q21 13 D 1.00 171 0.701 T l 107 0.77 -1.12 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 3.127 ? 83.07 +P01112 13 G K ? P01112 13 G K ? ? possibly damaging alignment ? deleterious 0.936 0.0568 0.802 0.0876 NO NO ? +1.583 -1.285 -2.868 2 212 20 20 6q21 13 D 1.00 171 0.701 T l 108 2.05 -1.12 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 13.780 13.780 83.07 +P01112 13 G L ? P01112 13 G L ? ? probably damaging alignment ? deleterious 0.993 0.0301 0.696 0.0553 NO NO ? +2.328 -1.285 -3.613 2 212 20 20 6q21 13 D 1.00 171 0.701 T l 107 0.84 -1.12 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 5.559 ? 83.07 +P01112 13 G M ? P01112 13 G M ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.533 -1.285 -4.818 2 212 20 20 6q21 13 D 1.00 171 0.701 T l 103 0.84 -1.12 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.243 ? 83.07 +P01112 13 G N ? P01112 13 G N ? ? probably damaging alignment ? deleterious 0.993 0.0301 0.696 0.0553 NO NO ? +2.375 -1.285 -3.660 2 212 20 20 6q21 13 D 1.00 171 0.701 T l 54 0.32 -1.12 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 4.955 ? 83.07 +P01112 13 G P ? P01112 13 G P ? ? probably damaging alignment ? deleterious 0.996 0.0222 0.545 0.0439 NO NO ? +2.729 -1.285 -4.014 2 212 20 20 6q21 13 D 1.00 171 0.701 T l 52 0.23 -1.12 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.419 ? 83.07 +P01112 13 G Q ? P01112 13 G Q ? ? probably damaging alignment ? deleterious 0.999 0.00574 0.136 0.0192 NO NO ? +2.824 -1.285 -4.109 2 212 20 20 6q21 13 D 1.00 171 0.701 T l 84 0.35 -1.12 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.748 ? 83.07 +P01112 13 G R ? P01112 13 G R G C probably damaging alignment ? deleterious 0.997 0.0167 0.409 0.0357 NO NO ? +2.706 -1.285 -3.991 2 212 20 20 6q21 13 D 1.00 171 0.701 T l 113 0.91 -1.12 ? ? ? ? ? ? ? 1 0 3 +75 PF00071.17 5.331 ? 83.07 +P01112 13 G S ? P01112 13 G S G A possibly damaging alignment ? deleterious 0.819 0.0702 0.839 0.102 NO NO ? +1.045 -1.285 -2.330 2 212 20 20 6q21 13 D 1.00 171 0.701 T l 29 0.02 -1.12 ? ? ? ? ? ? ? 0 0 1 +75 PF00071.17 18.269 18.269 83.07 +P01112 13 G T ? P01112 13 G T ? ? probably damaging alignment ? deleterious 0.993 0.0301 0.696 0.0553 NO NO ? +2.320 -1.285 -3.605 2 212 20 20 6q21 13 D 1.00 171 0.701 T l 56 0.07 -1.12 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 6.823 ? 83.07 +P01112 13 G V ? P01112 13 G V G T probably damaging alignment ? deleterious 0.996 0.0222 0.545 0.0439 NO NO ? +2.429 -1.285 -3.714 2 212 20 20 6q21 13 D 1.00 171 0.701 T l 80 0.73 -1.12 ? ? ? ? ? ? ? 1 1 0 +74 PF00071.17 3.424 ? 83.07 +P01112 13 G W ? P01112 13 G W ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.876 -1.285 -5.161 2 212 20 20 6q21 13 D 1.00 171 0.701 T l 167 0.76 -1.12 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.207 ? 83.07 +P01112 13 G Y ? P01112 13 G Y ? ? possibly damaging alignment ? deleterious 0.936 0.0568 0.802 0.0876 NO NO ? +1.753 -1.285 -3.038 2 212 20 20 6q21 13 D 1.00 171 0.701 T l 133 0.5 -1.12 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 13.939 13.939 83.07 +P01112 14 V A ? P01112 14 V A T C possibly damaging alignment ? deleterious 0.917 0.0597 0.812 0.0907 NO NO ? +1.361 -0.896 -2.257 2 212 20 20 6q21 14 D 1.00 171 0.000 S A -52 0.44 -0.97 ? 1 4.181 ? ? ? ? 0 1 2 +71 PF00071.17 19.924 19.924 68.78 +P01112 14 V C ? P01112 14 V C ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.739 -0.896 -4.635 2 212 20 20 6q21 14 D 1.00 171 0.000 S A -32 0.02 -0.97 ? 1 4.181 ? ? ? ? ? ? ? ? PF00071.17 1.474 ? 68.78 +P01112 14 V D ? P01112 14 V D ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.020 -0.896 -3.916 2 212 20 20 6q21 14 D 1.00 171 0.000 S A -29 1.19 -0.97 ? 1 4.181 ? ? ? ? ? ? ? ? PF00071.17 2.009 ? 68.78 +P01112 14 V E ? P01112 14 V E T A probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.766 -0.896 -3.662 2 212 20 20 6q21 14 D 1.00 171 0.000 S A -2 1.48 -0.97 ? 1 4.181 ? ? ? ? 1 1 0 +71 PF00071.17 2.769 ? 68.78 +P01112 14 V F ? P01112 14 V F ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.995 -0.896 -3.891 2 212 20 20 6q21 14 D 1.00 171 0.000 S A 50 0.14 -0.97 ? 1 4.181 ? ? ? ? ? ? ? ? PF00071.17 1.516 ? 68.78 +P01112 14 V G ? P01112 14 V G T G probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.609 -0.896 -3.505 2 212 20 20 6q21 14 D 1.00 171 0.000 S A -80 0.73 -0.97 ? 1 4.181 ? ? ? ? 1 1 0 +71 PF00071.17 5.390 ? 68.78 +P01112 14 V H ? P01112 14 V H ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +4.007 -0.896 -4.903 2 212 20 20 6q21 14 D 1.00 171 0.000 S A 13 0.61 -0.97 ? 1 4.181 ? ? ? ? ? ? ? ? PF00071.17 1.027 ? 68.78 +P01112 14 V I ? P01112 14 V I ? ? probably damaging alignment ? deleterious 0.999 0.00574 0.136 0.0192 NO NO ? +1.860 -0.896 -2.756 2 212 20 20 6q21 14 D 1.00 171 0.000 S A 27 0.04 -0.97 ? 1 4.181 ? ? ? ? ? ? ? ? PF00071.17 2.955 ? 68.78 +P01112 14 V K ? P01112 14 V K ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.783 -0.896 -3.679 2 212 20 20 6q21 14 D 1.00 171 0.000 S A 28 2.78 -0.97 ? 1 4.181 ? ? ? ? ? ? ? ? PF00071.17 3.102 ? 68.78 +P01112 14 V L ? P01112 14 V L G C probably damaging alignment ? deleterious 0.997 0.0167 0.409 0.0357 NO NO ? +1.855 -0.896 -2.751 2 212 20 20 6q21 14 D 1.00 171 0.000 S A 27 0.11 -0.97 ? 1 4.181 ? ? ? ? 1 0 0 +72 PF00071.17 4.095 ? 68.78 +P01112 14 V M ? P01112 14 V M G A probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.202 -0.896 -4.098 2 212 20 20 6q21 14 D 1.00 171 0.000 S A 23 0.11 -0.97 ? 1 4.181 ? ? ? ? 0 0 0 +72 PF00071.17 1.243 ? 68.78 +P01112 14 V N ? P01112 14 V N ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.224 -0.896 -4.120 2 212 20 20 6q21 14 D 1.00 171 0.000 S A -26 1.05 -0.97 ? 1 4.181 ? ? ? ? ? ? ? ? PF00071.17 1.807 ? 68.78 +P01112 14 V P ? P01112 14 V P ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.981 -0.896 -3.877 2 212 20 20 6q21 14 D 1.00 171 0.000 S A -28 0.96 -0.97 ? 1 4.181 ? ? ? ? ? ? ? ? PF00071.17 1.999 ? 68.78 +P01112 14 V Q ? P01112 14 V Q ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.226 -0.896 -4.122 2 212 20 20 6q21 14 D 1.00 171 0.000 S A 4 1.08 -0.97 ? 1 4.181 ? ? ? ? ? ? ? ? PF00071.17 1.783 ? 68.78 +P01112 14 V R ? P01112 14 V R ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.225 -0.896 -4.121 2 212 20 20 6q21 14 D 1.00 171 0.000 S A 33 1.64 -0.97 ? 1 4.181 ? ? ? ? ? ? ? ? PF00071.17 2.175 ? 68.78 +P01112 14 V S ? P01112 14 V S ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.636 -0.896 -3.532 2 212 20 20 6q21 14 D 1.00 171 0.000 S A -51 0.71 -0.97 ? 1 4.181 ? ? ? ? ? ? ? ? PF00071.17 5.795 ? 68.78 +P01112 14 V T ? P01112 14 V T ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.326 -0.896 -3.222 2 212 20 20 6q21 14 D 1.00 171 0.000 S A -24 0.66 -0.97 ? 1 4.181 ? ? ? ? ? ? ? ? PF00071.17 3.446 ? 68.78 +P01112 14 V W ? P01112 14 V W ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +4.452 -0.896 -5.348 2 212 20 20 6q21 14 D 1.00 171 0.000 S A 87 0.03 -0.97 ? 1 4.181 ? ? ? ? ? ? ? ? PF00071.17 0.373 ? 68.78 +P01112 14 V Y ? P01112 14 V Y ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.090 -0.896 -3.986 2 212 20 20 6q21 14 D 1.00 171 0.000 S A 53 0.23 -0.97 ? 1 4.181 ? ? ? ? ? ? ? ? PF00071.17 1.205 ? 68.78 +P01112 15 G A ? P01112 15 G A G C probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.171 -0.753 -2.924 2 212 20 20 6q21 15 D 1.00 171 0.195 S g 28 0.29 -0.44 ? ? ? ? ? ? ? 1 1 0 +68 PF00071.17 4.279 ? 77.78 +P01112 15 G C ? P01112 15 G C G T probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +4.405 -0.753 -5.158 2 212 20 20 6q21 15 D 1.00 171 0.195 S g 48 0.75 -0.44 ? ? ? ? ? ? ? 1 0 0 +69 PF00071.17 0.549 ? 77.78 +P01112 15 G D ? P01112 15 G D G A probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.609 -0.753 -3.362 2 212 20 20 6q21 15 D 1.00 171 0.195 S g 51 0.46 -0.44 ? ? ? ? ? ? ? 0 1 0 +68 PF00071.17 7.040 ? 77.78 +P01112 15 G E ? P01112 15 G E ? ? probably damaging alignment ? deleterious 0.994 0.0289 0.689 0.0537 NO NO ? +1.583 -0.753 -2.336 2 212 20 20 6q21 15 D 1.00 171 0.195 S g 78 0.75 -0.44 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 23.105 23.105 77.78 +P01112 15 G F ? P01112 15 G F ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.577 -0.753 -4.330 2 212 20 20 6q21 15 D 1.00 171 0.195 S g 130 0.87 -0.44 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.220 ? 77.78 +P01112 15 G H ? P01112 15 G H ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.877 -0.753 -4.630 2 212 20 20 6q21 15 D 1.00 171 0.195 S g 93 0.12 -0.44 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.957 ? 77.78 +P01112 15 G I ? P01112 15 G I ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.480 -0.753 -4.233 2 212 20 20 6q21 15 D 1.00 171 0.195 S g 107 0.77 -0.44 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.746 ? 77.78 +P01112 15 G K ? P01112 15 G K ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.822 -0.753 -3.575 2 212 20 20 6q21 15 D 1.00 171 0.195 S g 108 2.05 -0.44 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 5.918 ? 77.78 +P01112 15 G L ? P01112 15 G L ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.053 -0.753 -3.806 2 212 20 20 6q21 15 D 1.00 171 0.195 S g 107 0.84 -0.44 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.868 ? 77.78 +P01112 15 G M ? P01112 15 G M ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +4.175 -0.753 -4.928 2 212 20 20 6q21 15 D 1.00 171 0.195 S g 103 0.84 -0.44 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 0.973 ? 77.78 +P01112 15 G N ? P01112 15 G N ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.733 -0.753 -3.486 2 212 20 20 6q21 15 D 1.00 171 0.195 S g 54 0.32 -0.44 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 3.164 ? 77.78 +P01112 15 G P ? P01112 15 G P ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.125 -0.753 -3.878 2 212 20 20 6q21 15 D 1.00 171 0.195 S g 52 0.23 -0.44 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.036 ? 77.78 +P01112 15 G Q ? P01112 15 G Q ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.198 -0.753 -3.951 2 212 20 20 6q21 15 D 1.00 171 0.195 S g 84 0.35 -0.44 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 5.067 ? 77.78 +P01112 15 G R ? P01112 15 G R G C probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.130 -0.753 -3.883 2 212 20 20 6q21 15 D 1.00 171 0.195 S g 113 0.91 -0.44 ? ? ? ? ? ? ? 1 0 2 +69 PF00071.17 3.857 ? 77.78 +P01112 15 G S ? P01112 15 G S G A probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.445 -0.753 -3.198 2 212 20 20 6q21 15 D 1.00 171 0.195 S g 29 0.02 -0.44 ? ? ? ? ? ? ? 0 0 0 +69 PF00071.17 4.230 ? 77.78 +P01112 15 G T ? P01112 15 G T ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.891 -0.753 -3.644 2 212 20 20 6q21 15 D 1.00 171 0.195 S g 56 0.07 -0.44 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.935 ? 77.78 +P01112 15 G V ? P01112 15 G V G T probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.999 -0.753 -3.752 2 212 20 20 6q21 15 D 1.00 171 0.195 S g 80 0.73 -0.44 ? ? ? ? ? ? ? 1 1 0 +68 PF00071.17 2.433 ? 77.78 +P01112 15 G W ? P01112 15 G W ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +4.415 -0.753 -5.168 2 212 20 20 6q21 15 D 1.00 171 0.195 S g 167 0.76 -0.44 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 0.379 ? 77.78 +P01112 15 G Y ? P01112 15 G Y ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.632 -0.753 -4.385 2 212 20 20 6q21 15 D 1.00 171 0.195 S g 133 0.5 -0.44 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.247 ? 77.78 +P01112 16 K A ? P01112 16 K A ? ? probably damaging structure 2.2.3 deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.203 -0.912 -3.115 2 225 20 20 6q21 16 D 1.00 171 0.051 H A -80 2.34 -0.66 ? 1 2.349 ? ? ? ? ? ? ? ? PF00071.17 3.930 ? 71.43 +P01112 16 K C ? P01112 16 K C ? ? probably damaging structure 2.2.3 deleterious 1 0.00026 0.00018 0.0109 NO NO ? +4.246 -0.912 -5.158 2 225 20 20 6q21 16 D 1.00 171 0.051 H A -60 2.8 -0.66 ? 1 2.349 ? ? ? ? ? ? ? ? PF00071.17 0.504 ? 71.43 +P01112 16 K D ? P01112 16 K D ? ? probably damaging structure 2.2.3 deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.450 -0.912 -3.362 2 225 20 20 6q21 16 D 1.00 171 0.051 H A -57 1.59 -0.66 ? 1 2.349 ? ? ? ? ? ? ? ? PF00071.17 6.465 ? 71.43 +P01112 16 K E ? P01112 16 K E A G possibly damaging structure 2.2.3 deleterious 0.917 0.0597 0.812 0.0907 NO NO ? +1.236 -0.912 -2.148 2 225 20 20 6q21 16 D 1.00 171 0.051 H A -30 1.3 -0.66 ? 1 2.349 ? ? ? ? 0 0 2 +66 PF00071.17 21.219 21.219 71.43 +P01112 16 K F ? P01112 16 K F ? ? probably damaging structure 2.2.3 deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.418 -0.912 -4.330 2 225 20 20 6q21 16 D 1.00 171 0.051 H A 22 2.92 -0.66 ? 1 2.349 ? ? ? ? ? ? ? ? PF00071.17 1.120 ? 71.43 +P01112 16 K G ? P01112 16 K G ? ? probably damaging structure 2.2.3 deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.484 -0.912 -3.396 2 225 20 20 6q21 16 D 1.00 171 0.051 H A -108 2.05 -0.66 ? 1 2.349 ? ? ? ? ? ? ? ? PF00071.17 2.549 ? 71.43 +P01112 16 K H ? P01112 16 K H ? ? probably damaging structure 2.2.3 deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.541 -0.912 -4.453 2 225 20 20 6q21 16 D 1.00 171 0.051 H A -15 2.17 -0.66 ? 1 2.349 ? ? ? ? ? ? ? ? PF00071.17 1.798 ? 71.43 +P01112 16 K I ? P01112 16 K I ? ? probably damaging structure 2.2.3 deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.136 -0.912 -4.048 2 225 20 20 6q21 16 D 1.00 171 0.051 H A -1 2.82 -0.66 ? 1 2.349 ? ? ? ? ? ? ? ? PF00071.17 1.603 ? 71.43 +P01112 16 K L ? P01112 16 K L ? ? probably damaging structure 2.2.3 deleterious 0.997 0.0167 0.409 0.0357 NO NO ? +2.517 -0.912 -3.429 2 225 20 20 6q21 16 D 1.00 171 0.051 H A -1 2.89 -0.66 ? 1 2.349 ? ? ? ? ? ? ? ? PF00071.17 2.634 ? 71.43 +P01112 16 K M ? P01112 16 K M A T probably damaging structure 2.2.3 deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.639 -0.912 -4.551 2 225 20 20 6q21 16 D 1.00 171 0.051 H A -5 2.89 -0.66 ? 1 2.349 ? ? ? ? 1 1 0 +65 PF00071.17 0.893 ? 71.43 +P01112 16 K N ? P01112 16 K N G C probably damaging structure 2.2.3 deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.574 -0.912 -3.486 2 225 20 20 6q21 16 D 1.00 171 0.051 H A -54 1.73 -0.66 ? 1 2.349 ? ? ? ? 1 2 0 +64 PF00071.17 2.906 ? 71.43 +P01112 16 K P ? P01112 16 K P ? ? probably damaging structure 2.2.3 deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.780 -0.912 -3.692 2 225 20 20 6q21 16 D 1.00 171 0.051 H A -56 1.82 -0.66 ? 1 2.349 ? ? ? ? ? ? ? ? PF00071.17 1.870 ? 71.43 +P01112 16 K Q ? P01112 16 K Q A C probably damaging structure 2.2.3 deleterious 0.998 0.0112 0.273 0.0274 NO NO ? +2.535 -0.912 -3.447 2 225 20 20 6q21 16 D 1.00 171 0.051 H A -24 1.7 -0.66 ? 1 2.349 ? ? ? ? 1 0 0 +66 PF00071.17 4.654 ? 71.43 +P01112 16 K R ? P01112 16 K R A G probably damaging structure 2.2.3 deleterious 0.999 0.00574 0.136 0.0192 NO NO ? +2.219 -0.912 -3.131 2 225 20 20 6q21 16 D 1.00 171 0.051 H A 5 1.14 -0.66 ? 1 2.349 ? ? ? ? 0 1 0 +65 PF00071.17 3.542 ? 71.43 +P01112 16 K S ? P01112 16 K S ? ? probably damaging structure 2.2.3 deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.286 -0.912 -3.198 2 225 20 20 6q21 16 D 1.00 171 0.051 H A -79 2.07 -0.66 ? 1 2.349 ? ? ? ? ? ? ? ? PF00071.17 3.885 ? 71.43 +P01112 16 K T ? P01112 16 K T A C probably damaging structure 2.2.3 deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.547 -0.912 -3.459 2 225 20 20 6q21 16 D 1.00 171 0.051 H A -52 2.12 -0.66 ? 1 2.349 ? ? ? ? 1 1 2 +65 PF00071.17 2.695 ? 71.43 +P01112 16 K V ? P01112 16 K V ? ? probably damaging structure 2.2.3 deleterious 0.999 0.00574 0.136 0.0192 NO NO ? +2.654 -0.912 -3.566 2 225 20 20 6q21 16 D 1.00 171 0.051 H A -28 2.78 -0.66 ? 1 2.349 ? ? ? ? ? ? ? ? PF00071.17 2.234 ? 71.43 +P01112 16 K W ? P01112 16 K W ? ? probably damaging structure 2.2.3 deleterious 1 0.00026 0.00018 0.0109 NO NO ? +4.448 -0.912 -5.360 2 225 20 20 6q21 16 D 1.00 171 0.051 H A 59 2.81 -0.66 ? 1 2.349 ? ? ? ? ? ? ? ? PF00071.17 0.348 ? 71.43 +P01112 16 K Y ? P01112 16 K Y ? ? probably damaging structure 2.2.3 deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.288 -0.912 -4.200 2 225 20 20 6q21 16 D 1.00 171 0.051 H A 25 2.55 -0.66 ? 1 2.349 ? ? ? ? ? ? ? ? PF00071.17 1.145 ? 71.43 +P01112 17 S A ? P01112 17 S A ? ? probably damaging alignment ? deleterious 0.997 0.0167 0.409 0.0357 NO NO ? +1.728 -1.010 -2.738 2 225 20 20 6q21 17 D 1.00 171 0.192 H A -1 0.27 -0.35 ? 1 3.005 ? ? ? ? ? ? ? ? PF00071.17 3.324 ? 45.50 +P01112 17 S C ? P01112 17 S C A T probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.688 -1.010 -4.698 2 225 20 20 6q21 17 D 1.00 171 0.192 H A 19 0.73 -0.35 ? 1 3.005 ? ? ? ? 1 0 0 +63 PF00071.17 0.832 ? 45.50 +P01112 17 S D ? P01112 17 S D ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.344 -1.010 -3.354 2 225 20 20 6q21 17 D 1.00 171 0.192 H A 22 0.48 -0.35 ? 1 3.005 ? ? ? ? ? ? ? ? PF00071.17 1.695 ? 45.50 +P01112 17 S E ? P01112 17 S E ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.315 -1.010 -3.325 2 225 20 20 6q21 17 D 1.00 171 0.192 H A 49 0.77 -0.35 ? 1 3.005 ? ? ? ? ? ? ? ? PF00071.17 1.832 ? 45.50 +P01112 17 S F ? P01112 17 S F ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.117 -1.010 -4.127 2 225 20 20 6q21 17 D 1.00 171 0.192 H A 101 0.85 -0.35 ? 1 3.005 ? ? ? ? ? ? ? ? PF00071.17 1.039 ? 45.50 +P01112 17 S G ? P01112 17 S G A G probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.051 -1.010 -3.061 2 225 20 20 6q21 17 D 1.00 171 0.192 H A -29 0.02 -0.35 ? 1 3.005 ? ? ? ? 0 0 0 +63 PF00071.17 1.954 ? 45.50 +P01112 17 S H ? P01112 17 S H ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.556 -1.010 -4.566 2 225 20 20 6q21 17 D 1.00 171 0.192 H A 64 0.1 -0.35 ? 1 3.005 ? ? ? ? ? ? ? ? PF00071.17 0.665 ? 45.50 +P01112 17 S I ? P01112 17 S I G T probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.776 -1.010 -3.786 2 225 20 20 6q21 17 D 1.00 171 0.192 H A 78 0.75 -0.35 ? 1 3.005 ? ? ? ? 1 1 0 +62 PF00071.17 2.410 ? 45.50 +P01112 17 S K ? P01112 17 S K ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.332 -1.010 -3.342 2 225 20 20 6q21 17 D 1.00 171 0.192 H A 79 2.07 -0.35 ? 1 3.005 ? ? ? ? ? ? ? ? PF00071.17 2.098 ? 45.50 +P01112 17 S L ? P01112 17 S L ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.349 -1.010 -3.359 2 225 20 20 6q21 17 D 1.00 171 0.192 H A 78 0.82 -0.35 ? 1 3.005 ? ? ? ? ? ? ? ? PF00071.17 2.972 ? 45.50 +P01112 17 S M ? P01112 17 S M ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.530 -1.010 -4.540 2 225 20 20 6q21 17 D 1.00 171 0.192 H A 74 0.82 -0.35 ? 1 3.005 ? ? ? ? ? ? ? ? PF00071.17 0.903 ? 45.50 +P01112 17 S N ? P01112 17 S N G A probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.323 -1.010 -3.333 2 225 20 20 6q21 17 D 1.00 171 0.192 H A 25 0.34 -0.35 ? 1 3.005 ? ? ? ? 0 1 0 +62 PF00071.17 1.999 ? 45.50 +P01112 17 S P ? P01112 17 S P ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.705 -1.010 -3.715 2 225 20 20 6q21 17 D 1.00 171 0.192 H A 23 0.25 -0.35 ? 1 3.005 ? ? ? ? ? ? ? ? PF00071.17 1.208 ? 45.50 +P01112 17 S Q ? P01112 17 S Q ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.775 -1.010 -3.785 2 225 20 20 6q21 17 D 1.00 171 0.192 H A 55 0.37 -0.35 ? 1 3.005 ? ? ? ? ? ? ? ? PF00071.17 1.234 ? 45.50 +P01112 17 S R ? P01112 17 S R T A probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.758 -1.010 -3.768 2 225 20 20 6q21 17 D 1.00 171 0.192 H A 84 0.93 -0.35 ? 1 3.005 ? ? ? ? 1 2 0 +61 PF00071.17 1.592 ? 45.50 +P01112 17 S T ? P01112 17 S T G C probably damaging alignment ? deleterious 0.971 0.0444 0.768 0.0727 NO NO ? +0.858 -1.010 -1.868 2 225 20 20 6q21 17 D 1.00 171 0.192 H A 27 0.05 -0.35 ? 1 3.005 ? ? ? ? 1 1 0 +62 PF00071.17 11.190 11.190 45.50 +P01112 17 S V ? P01112 17 S V ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.450 -1.010 -3.460 2 225 20 20 6q21 17 D 1.00 171 0.192 H A 51 0.71 -0.35 ? 1 3.005 ? ? ? ? ? ? ? ? PF00071.17 3.255 ? 45.50 +P01112 17 S W ? P01112 17 S W ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +4.313 -1.010 -5.323 2 225 20 20 6q21 17 D 1.00 171 0.192 H A 138 0.74 -0.35 ? 1 3.005 ? ? ? ? ? ? ? ? PF00071.17 0.255 ? 45.50 +P01112 17 S Y ? P01112 17 S Y ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.213 -1.010 -4.223 2 225 20 20 6q21 17 D 1.00 171 0.192 H A 104 0.48 -0.35 ? 1 3.005 ? ? ? ? ? ? ? ? PF00071.17 0.842 ? 45.50 +P01112 18 A C ? P01112 18 A C ? ? probably damaging alignment ? deleterious 0.994 0.0289 0.689 0.0537 NO NO ? +1.982 -0.904 -2.886 2 225 20 20 6q21 18 D 1.00 171 0.136 H A 20 0.46 -0.48 ? 1 3.377 ? ? ? ? ? ? ? ? PF00071.17 26.083 26.083 71.43 +P01112 18 A D ? P01112 18 A D ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.834 -0.904 -3.738 2 225 20 20 6q21 18 D 1.00 171 0.136 H A 23 0.75 -0.48 ? 1 3.377 ? ? ? ? ? ? ? ? PF00071.17 2.661 ? 71.43 +P01112 18 A E ? P01112 18 A E C A probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.637 -0.904 -3.541 2 225 20 20 6q21 18 D 1.00 171 0.136 H A 50 1.04 -0.48 ? 1 3.377 ? ? ? ? 1 1 1 +59 PF00071.17 2.876 ? 71.43 +P01112 18 A F ? P01112 18 A F ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.212 -0.904 -4.116 2 225 20 20 6q21 18 D 1.00 171 0.136 H A 102 0.58 -0.48 ? 1 3.377 ? ? ? ? ? ? ? ? PF00071.17 1.632 ? 71.43 +P01112 18 A G ? P01112 18 A G C G probably damaging alignment ? deleterious 0.999 0.00574 0.136 0.0192 NO NO ? +2.145 -0.904 -3.049 2 225 20 20 6q21 18 D 1.00 171 0.136 H A -28 0.29 -0.48 ? 1 3.377 ? ? ? ? 1 1 1 +59 PF00071.17 3.068 ? 71.43 +P01112 18 A H ? P01112 18 A H ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.846 -0.904 -4.750 2 225 20 20 6q21 18 D 1.00 171 0.136 H A 65 0.17 -0.48 ? 1 3.377 ? ? ? ? ? ? ? ? PF00071.17 1.044 ? 71.43 +P01112 18 A I ? P01112 18 A I ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.706 -0.904 -3.610 2 225 20 20 6q21 18 D 1.00 171 0.136 H A 79 0.48 -0.48 ? 1 3.377 ? ? ? ? ? ? ? ? PF00071.17 3.783 ? 71.43 +P01112 18 A K ? P01112 18 A K ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.640 -0.904 -3.544 2 225 20 20 6q21 18 D 1.00 171 0.136 H A 80 2.34 -0.48 ? 1 3.377 ? ? ? ? ? ? ? ? PF00071.17 3.294 ? 71.43 +P01112 18 A L ? P01112 18 A L ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.278 -0.904 -3.182 2 225 20 20 6q21 18 D 1.00 171 0.136 H A 79 0.55 -0.48 ? 1 3.377 ? ? ? ? ? ? ? ? PF00071.17 4.665 ? 71.43 +P01112 18 A M ? P01112 18 A M ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.625 -0.904 -4.529 2 225 20 20 6q21 18 D 1.00 171 0.136 H A 75 0.55 -0.48 ? 1 3.377 ? ? ? ? ? ? ? ? PF00071.17 1.417 ? 71.43 +P01112 18 A N ? P01112 18 A N ? ? probably damaging alignment ? deleterious 0.999 0.00574 0.136 0.0192 NO NO ? +3.006 -0.904 -3.910 2 225 20 20 6q21 18 D 1.00 171 0.136 H A 26 0.61 -0.48 ? 1 3.377 ? ? ? ? ? ? ? ? PF00071.17 3.138 ? 71.43 +P01112 18 A P ? P01112 18 A P G C probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.838 -0.904 -3.742 2 225 20 20 6q21 18 D 1.00 171 0.136 H A 24 0.52 -0.48 ? 1 3.377 ? ? ? ? 1 0 0 +60 PF00071.17 1.896 ? 71.43 +P01112 18 A Q ? P01112 18 A Q ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.082 -0.904 -3.986 2 225 20 20 6q21 18 D 1.00 171 0.136 H A 56 0.64 -0.48 ? 1 3.377 ? ? ? ? ? ? ? ? PF00071.17 1.936 ? 71.43 +P01112 18 A R ? P01112 18 A R ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.891 -0.904 -3.795 2 225 20 20 6q21 18 D 1.00 171 0.136 H A 85 1.2 -0.48 ? 1 3.377 ? ? ? ? ? ? ? ? PF00071.17 2.499 ? 71.43 +P01112 18 A S ? P01112 18 A S G T probably damaging alignment ? deleterious 0.991 0.0326 0.711 0.0584 NO NO ? +2.119 -0.904 -3.023 2 225 20 20 6q21 18 D 1.00 171 0.136 H A 1 0.27 -0.48 ? 1 3.377 ? ? ? ? 1 0 0 +60 PF00071.17 6.597 ? 71.43 +P01112 18 A T ? P01112 18 A T G A probably damaging alignment ? deleterious 0.99 0.0338 0.719 0.06 NO NO ? +1.583 -0.904 -2.487 2 225 20 20 6q21 18 D 1.00 171 0.136 H A 28 0.22 -0.48 ? 1 3.377 ? ? ? ? 0 0 0 +60 PF00071.17 17.565 17.565 71.43 +P01112 18 A V ? P01112 18 A V C T probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.245 -0.904 -3.149 2 225 20 20 6q21 18 D 1.00 171 0.136 H A 52 0.44 -0.48 ? 1 3.377 ? ? ? ? 0 1 1 +59 PF00071.17 5.109 ? 71.43 +P01112 18 A W ? P01112 18 A W ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +4.417 -0.904 -5.321 2 225 20 20 6q21 18 D 1.00 171 0.136 H A 139 0.47 -0.48 ? 1 3.377 ? ? ? ? ? ? ? ? PF00071.17 0.401 ? 71.43 +P01112 18 A Y ? P01112 18 A Y ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.308 -0.904 -4.212 2 225 20 20 6q21 18 D 1.00 171 0.136 H A 105 0.21 -0.48 ? 1 3.377 ? ? ? ? ? ? ? ? PF00071.17 1.322 ? 71.43 +P01112 19 L A ? P01112 19 L A ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.365 -0.741 -3.106 2 225 20 20 6q21 19 D 1.00 171 0.000 H A -79 0.55 -0.63 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 ? ? ? +P01112 19 L C ? P01112 19 L C ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.924 -0.741 -4.665 2 225 20 20 6q21 19 D 1.00 171 0.000 H A -59 0.09 -0.63 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 ? ? ? +P01112 19 L D ? P01112 19 L D ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.431 -0.741 -4.172 2 225 20 20 6q21 19 D 1.00 171 0.000 H A -56 1.3 -0.63 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 ? ? ? +P01112 19 L E ? P01112 19 L E ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.177 -0.741 -3.918 2 225 20 20 6q21 19 D 1.00 171 0.000 H A -29 1.59 -0.63 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 ? ? ? +P01112 19 L F ? P01112 19 L F ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.904 -0.741 -3.645 2 225 20 20 6q21 19 D 1.00 171 0.000 H A 23 0.03 -0.63 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 ? ? ? +P01112 19 L G ? P01112 19 L G ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.095 -0.741 -3.836 2 225 20 20 6q21 19 D 1.00 171 0.000 H A -107 0.84 -0.63 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 ? ? ? +P01112 19 L H ? P01112 19 L H ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +4.192 -0.741 -4.933 2 225 20 20 6q21 19 D 1.00 171 0.000 H A -14 0.72 -0.63 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 ? ? ? +P01112 19 L I ? P01112 19 L I ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.173 -0.741 -2.914 2 225 20 20 6q21 19 D 1.00 171 0.000 H A 0 0.07 -0.63 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 ? ? ? +P01112 19 L K ? P01112 19 L K ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.969 -0.741 -3.710 2 225 20 20 6q21 19 D 1.00 171 0.000 H A 1 2.89 -0.63 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 ? ? ? +P01112 19 L M ? P01112 19 L M C A probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.092 -0.741 -3.833 2 225 20 20 6q21 19 D 1.00 171 0.000 H A -4 0 -0.63 ? ? ? ? ? ? ? 1 0 0 +57 PF00071.17 ? ? ? +P01112 19 L N ? P01112 19 L N ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.410 -0.741 -4.151 2 225 20 20 6q21 19 D 1.00 171 0.000 H A -53 1.16 -0.63 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 ? ? ? +P01112 19 L P ? P01112 19 L P T C probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.392 -0.741 -4.133 2 225 20 20 6q21 19 D 1.00 171 0.000 H A -55 1.07 -0.63 ? ? ? ? ? ? ? 0 1 2 +56 PF00071.17 ? ? ? +P01112 19 L Q ? P01112 19 L Q T A probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.412 -0.741 -4.153 2 225 20 20 6q21 19 D 1.00 171 0.000 H A -23 1.19 -0.63 ? ? ? ? ? ? ? 1 1 0 +56 PF00071.17 ? ? ? +P01112 19 L R ? P01112 19 L R T G probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.220 -0.741 -3.961 2 225 20 20 6q21 19 D 1.00 171 0.000 H A 6 1.75 -0.63 ? ? ? ? ? ? ? 1 1 2 +56 PF00071.17 ? ? ? +P01112 19 L S ? P01112 19 L S ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.898 -0.741 -3.639 2 225 20 20 6q21 19 D 1.00 171 0.000 H A -78 0.82 -0.63 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 ? ? ? +P01112 19 L T ? P01112 19 L T ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.709 -0.741 -3.450 2 225 20 20 6q21 19 D 1.00 171 0.000 H A -51 0.77 -0.63 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 ? ? ? +P01112 19 L V ? P01112 19 L V C G probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.141 -0.741 -2.882 2 225 20 20 6q21 19 D 1.00 171 0.000 H A -27 0.11 -0.63 ? ? ? ? ? ? ? 1 0 0 +57 PF00071.17 ? ? ? +P01112 19 L W ? P01112 19 L W ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +4.385 -0.741 -5.126 2 225 20 20 6q21 19 D 1.00 171 0.000 H A 60 0.08 -0.63 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 ? ? ? +P01112 19 L Y ? P01112 19 L Y ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.225 -0.741 -3.966 2 225 20 20 6q21 19 D 1.00 171 0.000 H A 26 0.34 -0.63 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 ? ? ? +P01112 20 T A ? P01112 20 T A A G probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +1.965 -0.978 -2.943 2 225 20 20 6q21 20 D 1.00 171 0.000 H A -28 0.22 -0.28 ? ? ? ? ? ? ? 0 0 0 +54 PF00071.17 3.089 ? 46.03 +P01112 20 T C ? P01112 20 T C ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.720 -0.978 -4.698 2 225 20 20 6q21 20 D 1.00 171 0.000 H A -8 0.68 -0.28 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 0.829 ? 46.03 +P01112 20 T D ? P01112 20 T D ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.643 -0.978 -3.621 2 225 20 20 6q21 20 D 1.00 171 0.000 H A -5 0.53 -0.28 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 0.837 ? 46.03 +P01112 20 T E ? P01112 20 T E ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.597 -0.978 -3.575 2 225 20 20 6q21 20 D 1.00 171 0.000 H A 22 0.82 -0.28 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.035 ? 46.03 +P01112 20 T F ? P01112 20 T F ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.047 -0.978 -4.025 2 225 20 20 6q21 20 D 1.00 171 0.000 H A 74 0.8 -0.28 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.064 ? 46.03 +P01112 20 T G ? P01112 20 T G ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.516 -0.978 -3.494 2 225 20 20 6q21 20 D 1.00 171 0.000 H A -56 0.07 -0.28 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.110 ? 46.03 +P01112 20 T H ? P01112 20 T H ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.813 -0.978 -4.791 2 225 20 20 6q21 20 D 1.00 171 0.000 H A 37 0.05 -0.28 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 0.395 ? 46.03 +P01112 20 T I ? P01112 20 T I C T probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +1.407 -0.978 -2.385 2 225 20 20 6q21 20 D 1.00 171 0.000 H A 51 0.7 -0.28 ? ? ? ? ? ? ? 0 1 0 +53 PF00071.17 12.499 12.499 46.03 +P01112 20 T K ? P01112 20 T K ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.614 -0.978 -3.592 2 225 20 20 6q21 20 D 1.00 171 0.000 H A 52 2.12 -0.28 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.180 ? 46.03 +P01112 20 T L ? P01112 20 T L ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.037 -0.978 -3.015 2 225 20 20 6q21 20 D 1.00 171 0.000 H A 51 0.77 -0.28 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 7.715 ? 46.03 +P01112 20 T M ? P01112 20 T M ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.433 -0.978 -4.411 2 225 20 20 6q21 20 D 1.00 171 0.000 H A 47 0.77 -0.28 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.700 ? 46.03 +P01112 20 T N ? P01112 20 T N C A probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.657 -0.978 -3.635 2 225 20 20 6q21 20 D 1.00 171 0.000 H A -2 0.39 -0.28 ? ? ? ? ? ? ? 1 1 0 +53 PF00071.17 0.732 ? 46.03 +P01112 20 T P ? P01112 20 T P A C probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.812 -0.978 -3.790 2 225 20 20 6q21 20 D 1.00 171 0.000 H A -4 0.3 -0.28 ? ? ? ? ? ? ? 1 0 0 +54 PF00071.17 0.759 ? 46.03 +P01112 20 T Q ? P01112 20 T Q ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.057 -0.978 -4.035 2 225 20 20 6q21 20 D 1.00 171 0.000 H A 28 0.42 -0.28 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 0.711 ? 46.03 +P01112 20 T R ? P01112 20 T R ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.882 -0.978 -3.860 2 225 20 20 6q21 20 D 1.00 171 0.000 H A 57 0.98 -0.28 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 0.964 ? 46.03 +P01112 20 T S ? P01112 20 T S C G probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.145 -0.978 -3.123 2 225 20 20 6q21 20 D 1.00 171 0.000 H A -27 0.05 -0.28 ? ? ? ? ? ? ? 1 1 0 +53 PF00071.17 1.438 ? 46.03 +P01112 20 T V ? P01112 20 T V ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +1.417 -0.978 -2.395 2 225 20 20 6q21 20 D 1.00 171 0.000 H A 24 0.66 -0.28 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 11.966 11.966 46.03 +P01112 20 T W ? P01112 20 T W ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +4.230 -0.978 -5.208 2 225 20 20 6q21 20 D 1.00 171 0.000 H A 111 0.69 -0.28 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 0.245 ? 46.03 +P01112 20 T Y ? P01112 20 T Y ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.185 -0.978 -4.163 2 225 20 20 6q21 20 D 1.00 171 0.000 H A 77 0.43 -0.28 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 0.944 ? 46.03 +P01112 21 I A ? P01112 21 I A ? ? probably damaging alignment ? deleterious 0.985 0.0375 0.74 0.0643 NO NO ? +1.816 -1.332 -3.148 2 225 20 20 6q21 21 D 1.00 171 0.030 H A -79 0.48 -0.12 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 7.110 ? 75.13 +P01112 21 I C ? P01112 21 I C ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.462 -1.332 -4.794 2 225 20 20 6q21 21 D 1.00 171 0.030 H A -59 0.02 -0.12 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.186 ? 75.13 +P01112 21 I D ? P01112 21 I D ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.570 -1.332 -3.902 2 225 20 20 6q21 21 D 1.00 171 0.030 H A -56 1.23 -0.12 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 6.261 ? 75.13 +P01112 21 I E ? P01112 21 I E ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.498 -1.332 -3.830 2 225 20 20 6q21 21 D 1.00 171 0.030 H A -29 1.52 -0.12 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 3.719 ? 75.13 +P01112 21 I F ? P01112 21 I F A T probably damaging alignment ? deleterious 0.997 0.0167 0.409 0.0357 NO NO ? +2.510 -1.332 -3.842 2 225 20 20 6q21 21 D 1.00 171 0.030 H A 23 0.1 -0.12 ? ? ? ? ? ? ? 1 0 0 +51 PF00071.17 2.665 ? 75.13 +P01112 21 I G ? P01112 21 I G ? ? probably damaging alignment ? deleterious 0.996 0.0222 0.545 0.0439 NO NO ? +2.360 -1.332 -3.692 2 225 20 20 6q21 21 D 1.00 171 0.030 H A -107 0.77 -0.12 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 4.812 ? 75.13 +P01112 21 I H ? P01112 21 I H ? ? probably damaging alignment ? deleterious 0.999 0.00574 0.136 0.0192 NO NO ? +3.538 -1.332 -4.870 2 225 20 20 6q21 21 D 1.00 171 0.030 H A -14 0.65 -0.12 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.407 ? 75.13 +P01112 21 I K ? P01112 21 I K ? ? probably damaging alignment ? deleterious 0.998 0.0112 0.273 0.0274 NO NO ? +2.464 -1.332 -3.796 2 225 20 20 6q21 21 D 1.00 171 0.030 H A 1 2.82 -0.12 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 4.107 ? 75.13 +P01112 21 I L ? P01112 21 I L A C benign alignment ? neutral 0.015 0.209 0.956 0.229 NO NO ? +0.986 -1.332 -2.318 2 225 20 20 6q21 21 D 1.00 171 0.030 H A 0 0.07 -0.12 ? ? ? ? ? ? ? 1 0 0 +51 PF00071.17 18.279 18.279 75.13 +P01112 21 I M ? P01112 21 I M C G benign alignment ? neutral 0.287 0.115 0.907 0.147 NO NO ? +1.235 -1.332 -2.567 2 225 20 20 6q21 21 D 1.00 171 0.030 H A -4 0.07 -0.12 ? ? ? ? ? ? ? 1 2 0 +49 PF00071.17 8.227 8.227 75.13 +P01112 21 I N ? P01112 21 I N T A probably damaging structure 1.1.1 deleterious 0.992 0.0314 0.704 0.0568 NO NO ? +1.621 -1.332 -2.953 2 225 20 20 6q21 21 D 1.00 171 0.030 H A -53 1.09 -0.12 ? ? ? ? ? ? ? 1 1 0 +50 PF00071.17 23.796 23.796 75.13 +P01112 21 I P ? P01112 21 I P ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.781 -1.332 -4.113 2 225 20 20 6q21 21 D 1.00 171 0.030 H A -55 1 -0.12 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.895 ? 75.13 +P01112 21 I Q ? P01112 21 I Q ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.863 -1.332 -4.195 2 225 20 20 6q21 21 D 1.00 171 0.030 H A -23 1.12 -0.12 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.576 ? 75.13 +P01112 21 I R ? P01112 21 I R ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.767 -1.332 -4.099 2 225 20 20 6q21 21 D 1.00 171 0.030 H A 6 1.68 -0.12 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 3.330 ? 75.13 +P01112 21 I S ? P01112 21 I S T G possibly damaging alignment ? deleterious 0.945 0.054 0.796 0.0842 NO NO ? +1.476 -1.332 -2.808 2 225 20 20 6q21 21 D 1.00 171 0.030 H A -78 0.75 -0.12 ? ? ? ? ? ? ? 1 1 0 +50 PF00071.17 14.312 14.312 75.13 +P01112 21 I T ? P01112 21 I T T C probably damaging alignment ? deleterious 0.981 0.0399 0.75 0.0672 NO NO ? +2.130 -1.332 -3.462 2 225 20 20 6q21 21 D 1.00 171 0.030 H A -51 0.7 -0.12 ? ? ? ? ? ? ? 0 1 0 +50 PF00071.17 5.345 ? 75.13 +P01112 21 I V ? P01112 21 I V A G benign alignment ? neutral 0.108 0.143 0.928 0.173 NO NO ? +0.735 -1.332 -2.067 2 225 20 20 6q21 21 D 1.00 171 0.030 H A -27 0.04 -0.12 ? ? ? ? ? ? ? 0 0 2 +51 PF00071.17 14.815 14.815 75.13 +P01112 21 I W ? P01112 21 I W ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +4.040 -1.332 -5.372 2 225 20 20 6q21 21 D 1.00 171 0.030 H A 60 0.01 -0.12 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 0.404 ? 75.13 +P01112 21 I Y ? P01112 21 I Y ? ? probably damaging alignment ? deleterious 0.998 0.0112 0.273 0.0274 NO NO ? +2.765 -1.332 -4.097 2 225 20 20 6q21 21 D 1.00 171 0.030 H A 26 0.27 -0.12 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.179 ? 75.13 +P01112 22 Q A ? P01112 22 Q A ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.161 -0.990 -3.151 2 225 20 20 6q21 22 D 1.00 171 0.039 H A -56 0.64 0.23 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 4.279 ? 77.78 +P01112 22 Q C ? P01112 22 Q C ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +4.189 -0.990 -5.179 2 225 20 20 6q21 22 D 1.00 171 0.039 H A -36 1.1 0.23 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 0.549 ? 77.78 +P01112 22 Q D ? P01112 22 Q D ? ? probably damaging alignment ? deleterious 0.998 0.0112 0.273 0.0274 NO NO ? +2.308 -0.990 -3.298 2 225 20 20 6q21 22 D 1.00 171 0.039 H A -33 0.11 0.23 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 7.040 ? 77.78 +P01112 22 Q E ? P01112 22 Q E C G possibly damaging alignment ? deleterious 0.84 0.0683 0.836 0.0997 NO NO ? +1.352 -0.990 -2.342 2 225 20 20 6q21 22 D 1.00 171 0.039 H A -6 0.4 0.23 ? ? ? ? ? ? ? 1 0 2 +48 PF00071.17 23.105 23.105 77.78 +P01112 22 Q F ? P01112 22 Q F ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.375 -0.990 -4.365 2 225 20 20 6q21 22 D 1.00 171 0.039 H A 46 1.22 0.23 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.220 ? 77.78 +P01112 22 Q G ? P01112 22 Q G ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.441 -0.990 -3.431 2 225 20 20 6q21 22 D 1.00 171 0.039 H A -84 0.35 0.23 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.775 ? 77.78 +P01112 22 Q H ? P01112 22 Q H G C probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.313 -0.990 -4.303 2 225 20 20 6q21 22 D 1.00 171 0.039 H A 9 0.47 0.23 ? ? ? ? ? ? ? 1 2 0 +46 PF00071.17 1.957 ? 77.78 +P01112 22 Q I ? P01112 22 Q I ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.093 -0.990 -4.083 2 225 20 20 6q21 22 D 1.00 171 0.039 H A 23 1.12 0.23 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.746 ? 77.78 +P01112 22 Q K ? P01112 22 Q K C A probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.067 -0.990 -3.057 2 225 20 20 6q21 22 D 1.00 171 0.039 H A 24 1.7 0.23 ? ? ? ? ? ? ? 1 0 0 +48 PF00071.17 5.918 ? 77.78 +P01112 22 Q L ? P01112 22 Q L A T probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.460 -0.990 -3.450 2 225 20 20 6q21 22 D 1.00 171 0.039 H A 23 1.19 0.23 ? ? ? ? ? ? ? 1 1 0 +47 PF00071.17 2.868 ? 77.78 +P01112 22 Q M ? P01112 22 Q M ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.391 -0.990 -4.381 2 225 20 20 6q21 22 D 1.00 171 0.039 H A 19 1.19 0.23 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 0.973 ? 77.78 +P01112 22 Q N ? P01112 22 Q N ? ? probably damaging alignment ? deleterious 0.999 0.00574 0.136 0.0192 NO NO ? +2.531 -0.990 -3.521 2 225 20 20 6q21 22 D 1.00 171 0.039 H A -30 0.0299999999999999 0.23 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 3.164 ? 77.78 +P01112 22 Q P ? P01112 22 Q P A C probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.756 -0.990 -3.746 2 225 20 20 6q21 22 D 1.00 171 0.039 H A -32 0.12 0.23 ? ? ? ? ? ? ? 1 1 2 +47 PF00071.17 2.036 ? 77.78 +P01112 22 Q R ? P01112 22 Q R A G probably damaging alignment ? deleterious 0.972 0.0442 0.766 0.0725 NO NO ? +1.610 -0.990 -2.600 2 225 20 20 6q21 22 D 1.00 171 0.039 H A 29 0.56 0.23 ? ? ? ? ? ? ? 0 1 2 +47 PF00071.17 15.291 15.291 77.78 +P01112 22 Q S ? P01112 22 Q S ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.262 -0.990 -3.252 2 225 20 20 6q21 22 D 1.00 171 0.039 H A -55 0.37 0.23 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 4.230 ? 77.78 +P01112 22 Q T ? P01112 22 Q T ? ? probably damaging alignment ? deleterious 0.997 0.0167 0.409 0.0357 NO NO ? +2.504 -0.990 -3.494 2 225 20 20 6q21 22 D 1.00 171 0.039 H A -28 0.42 0.23 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.935 ? 77.78 +P01112 22 Q V ? P01112 22 Q V ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.630 -0.990 -3.620 2 225 20 20 6q21 22 D 1.00 171 0.039 H A -4 1.08 0.23 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.433 ? 77.78 +P01112 22 Q W ? P01112 22 Q W ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +4.218 -0.990 -5.208 2 225 20 20 6q21 22 D 1.00 171 0.039 H A 83 1.11 0.23 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 0.379 ? 77.78 +P01112 22 Q Y ? P01112 22 Q Y ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.058 -0.990 -4.048 2 225 20 20 6q21 22 D 1.00 171 0.039 H A 49 0.85 0.23 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.247 ? 77.78 +P01112 23 L A ? P01112 23 L A ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.069 -1.178 -3.247 2 225 20 20 6q21 23 D 1.00 171 0.000 H A -79 0.55 -0.53 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.355 ? 68.25 +P01112 23 L C ? P01112 23 L C ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.629 -1.178 -4.807 2 225 20 20 6q21 23 D 1.00 171 0.000 H A -59 0.09 -0.53 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 0.740 ? 68.25 +P01112 23 L D ? P01112 23 L D ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.942 -1.178 -4.120 2 225 20 20 6q21 23 D 1.00 171 0.000 H A -56 1.3 -0.53 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.094 ? 68.25 +P01112 23 L E ? P01112 23 L E ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.769 -1.178 -3.947 2 225 20 20 6q21 23 D 1.00 171 0.000 H A -29 1.59 -0.53 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.226 ? 68.25 +P01112 23 L F ? P01112 23 L F ? ? benign alignment ? neutral 0.425 0.103 0.892 0.135 NO NO ? +0.540 -1.178 -1.718 2 225 20 20 6q21 23 D 1.00 171 0.000 H A 23 0.03 -0.53 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 26.309 26.309 68.25 +P01112 23 L G ? P01112 23 L G ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.607 -1.178 -3.785 2 225 20 20 6q21 23 D 1.00 171 0.000 H A -107 0.84 -0.53 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.724 ? 68.25 +P01112 23 L H ? P01112 23 L H ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.485 -1.178 -4.663 2 225 20 20 6q21 23 D 1.00 171 0.000 H A -14 0.72 -0.53 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.095 ? 68.25 +P01112 23 L I ? P01112 23 L I ? ? probably damaging alignment ? deleterious 0.994 0.0289 0.689 0.0537 NO NO ? +1.969 -1.178 -3.147 2 225 20 20 6q21 23 D 1.00 171 0.000 H A 0 0.07 -0.53 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 4.384 ? 68.25 +P01112 23 L K ? P01112 23 L K ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.654 -1.178 -3.832 2 225 20 20 6q21 23 D 1.00 171 0.000 H A 1 2.89 -0.53 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.376 ? 68.25 +P01112 23 L M ? P01112 23 L M C A probably damaging alignment ? deleterious 0.999 0.00574 0.136 0.0192 NO NO ? +2.888 -1.178 -4.066 2 225 20 20 6q21 23 D 1.00 171 0.000 H A -4 0 -0.53 ? ? ? ? ? ? ? 1 0 0 +45 PF00071.17 1.713 ? 68.25 +P01112 23 L N ? P01112 23 L N ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.002 -1.178 -4.180 2 225 20 20 6q21 23 D 1.00 171 0.000 H A -53 1.16 -0.53 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.080 ? 68.25 +P01112 23 L P ? P01112 23 L P T C probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.077 -1.178 -4.255 2 225 20 20 6q21 23 D 1.00 171 0.000 H A -55 1.07 -0.53 ? ? ? ? ? ? ? 0 1 2 +44 PF00071.17 0.756 ? 68.25 +P01112 23 L Q ? P01112 23 L Q T A probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.072 -1.178 -4.250 2 225 20 20 6q21 23 D 1.00 171 0.000 H A -23 1.19 -0.53 ? ? ? ? ? ? ? 1 1 0 +44 PF00071.17 0.930 ? 68.25 +P01112 23 L R ? P01112 23 L R T G probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.905 -1.178 -4.083 2 225 20 20 6q21 23 D 1.00 171 0.000 H A 6 1.75 -0.53 ? ? ? ? ? ? ? 1 1 2 +44 PF00071.17 1.341 ? 68.25 +P01112 23 L S ? P01112 23 L S ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.512 -1.178 -3.690 2 225 20 20 6q21 23 D 1.00 171 0.000 H A -78 0.82 -0.53 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.719 ? 68.25 +P01112 23 L T ? P01112 23 L T ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.413 -1.178 -3.591 2 225 20 20 6q21 23 D 1.00 171 0.000 H A -51 0.77 -0.53 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.673 ? 68.25 +P01112 23 L V ? P01112 23 L V C G probably damaging alignment ? deleterious 0.994 0.0289 0.689 0.0537 NO NO ? +1.924 -1.178 -3.102 2 225 20 20 6q21 23 D 1.00 171 0.000 H A -27 0.11 -0.53 ? ? ? ? ? ? ? 1 0 0 +45 PF00071.17 3.708 ? 68.25 +P01112 23 L W ? P01112 23 L W ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.622 -1.178 -4.800 2 225 20 20 6q21 23 D 1.00 171 0.000 H A 60 0.08 -0.53 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.222 ? 68.25 +P01112 23 L Y ? P01112 23 L Y ? ? probably damaging alignment ? deleterious 0.993 0.0301 0.696 0.0553 NO NO ? +1.498 -1.178 -2.676 2 225 20 20 6q21 23 D 1.00 171 0.000 H A 26 0.34 -0.53 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 14.107 14.107 68.25 +P01112 24 I A ? P01112 24 I A ? ? possibly damaging alignment ? deleterious 0.956 0.0501 0.785 0.0796 NO NO ? +1.750 -1.400 -3.150 2 225 20 20 6q21 24 D 1.00 171 0.226 H a -79 0.48 0.14 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 5.025 ? 68.78 +P01112 24 I C ? P01112 24 I C ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.424 -1.400 -4.824 2 225 20 20 6q21 24 D 1.00 171 0.226 H a -59 0.02 0.14 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.258 ? 68.78 +P01112 24 I D ? P01112 24 I D ? ? probably damaging alignment ? deleterious 0.997 0.0167 0.409 0.0357 NO NO ? +2.481 -1.400 -3.881 2 225 20 20 6q21 24 D 1.00 171 0.226 H a -56 1.23 0.14 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.563 ? 68.78 +P01112 24 I E ? P01112 24 I E ? ? probably damaging alignment ? deleterious 0.991 0.0326 0.711 0.0584 NO NO ? +2.407 -1.400 -3.807 2 225 20 20 6q21 24 D 1.00 171 0.226 H a -29 1.52 0.14 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.770 ? 68.78 +P01112 24 I F ? P01112 24 I F A T possibly damaging alignment ? deleterious 0.689 0.083 0.861 0.116 NO NO ? +1.547 -1.400 -2.947 2 225 20 20 6q21 24 D 1.00 171 0.226 H a 23 0.1 0.14 ? ? ? ? ? ? ? 1 0 0 +42 PF00071.17 17.131 17.131 68.78 +P01112 24 I G ? P01112 24 I G ? ? probably damaging alignment ? deleterious 0.993 0.0301 0.696 0.0553 NO NO ? +2.307 -1.400 -3.707 2 225 20 20 6q21 24 D 1.00 171 0.226 H a -107 0.77 0.14 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 3.013 ? 68.78 +P01112 24 I H ? P01112 24 I H ? ? possibly damaging alignment ? deleterious 0.754 0.0773 0.852 0.109 NO NO ? +1.828 -1.400 -3.228 2 225 20 20 6q21 24 D 1.00 171 0.226 H a -14 0.65 0.14 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 14.611 14.611 68.78 +P01112 24 I K ? P01112 24 I K ? ? possibly damaging alignment ? deleterious 0.816 0.0707 0.84 0.102 NO NO ? +2.431 -1.400 -3.831 2 225 20 20 6q21 24 D 1.00 171 0.226 H a 1 2.82 0.14 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 3.172 ? 68.78 +P01112 24 I L ? P01112 24 I L A C benign alignment ? neutral 0.063 0.16 0.937 0.187 NO NO ? +1.030 -1.400 -2.430 2 225 20 20 6q21 24 D 1.00 171 0.226 H a 0 0.07 0.14 ? ? ? ? ? ? ? 1 0 0 +42 PF00071.17 18.279 18.279 68.78 +P01112 24 I M ? P01112 24 I M C G probably damaging alignment ? deleterious 0.99 0.0338 0.719 0.06 NO NO ? +2.915 -1.400 -4.315 2 225 20 20 6q21 24 D 1.00 171 0.226 H a -4 0.07 0.14 ? ? ? ? ? ? ? 1 2 0 +40 PF00071.17 2.426 ? 68.78 +P01112 24 I N ? P01112 24 I N T A probably damaging alignment ? deleterious 0.991 0.0326 0.711 0.0584 NO NO ? +2.542 -1.400 -3.942 2 225 20 20 6q21 24 D 1.00 171 0.226 H a -53 1.09 0.14 ? ? ? ? ? ? ? 1 1 0 +41 PF00071.17 3.022 ? 68.78 +P01112 24 I P ? P01112 24 I P ? ? probably damaging alignment ? deleterious 0.997 0.0167 0.409 0.0357 NO NO ? +2.693 -1.400 -4.093 2 225 20 20 6q21 24 D 1.00 171 0.226 H a -55 1 0.14 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.826 ? 68.78 +P01112 24 I Q ? P01112 24 I Q ? ? probably damaging alignment ? deleterious 0.998 0.0112 0.273 0.0274 NO NO ? +2.853 -1.400 -4.253 2 225 20 20 6q21 24 D 1.00 171 0.226 H a -23 1.12 0.14 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.865 ? 68.78 +P01112 24 I R ? P01112 24 I R ? ? probably damaging alignment ? deleterious 0.992 0.0314 0.704 0.0568 NO NO ? +2.696 -1.400 -4.096 2 225 20 20 6q21 24 D 1.00 171 0.226 H a 6 1.68 0.14 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.406 ? 68.78 +P01112 24 I S ? P01112 24 I S T G possibly damaging alignment ? deleterious 0.942 0.0552 0.798 0.0857 NO NO ? +1.404 -1.400 -2.804 2 225 20 20 6q21 24 D 1.00 171 0.226 H a -78 0.75 0.14 ? ? ? ? ? ? ? 1 1 0 +41 PF00071.17 9.891 9.891 68.78 +P01112 24 I T ? P01112 24 I T T C benign alignment ? neutral 0.115 0.142 0.927 0.172 NO NO ? +0.627 -1.400 -2.027 2 225 20 20 6q21 24 D 1.00 171 0.226 H a -51 0.7 0.14 ? ? ? ? ? ? ? 0 1 0 +41 PF00071.17 16.915 16.915 68.78 +P01112 24 I V ? P01112 24 I V A G benign alignment ? neutral 0.082 0.153 0.933 0.181 NO NO ? +1.042 -1.400 -2.442 2 225 20 20 6q21 24 D 1.00 171 0.226 H a -27 0.04 0.14 ? ? ? ? ? ? ? 0 0 0 +42 PF00071.17 13.390 13.390 68.78 +P01112 24 I W ? P01112 24 I W ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.904 -1.400 -5.304 2 225 20 20 6q21 24 D 1.00 171 0.226 H a 60 0.01 0.14 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 0.796 ? 68.78 +P01112 24 I Y ? P01112 24 I Y ? ? possibly damaging alignment ? deleterious 0.875 0.0653 0.826 0.0967 NO NO ? +2.586 -1.400 -3.986 2 225 20 20 6q21 24 D 1.00 171 0.226 H a 26 0.27 0.14 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 3.973 ? 68.78 +P01112 25 Q A ? P01112 25 Q A ? ? benign alignment ? neutral 0.359 0.108 0.898 0.141 NO NO ? +1.220 -1.351 -2.571 2 225 20 20 6q21 25 D 1.00 171 0.685 T A -56 0.64 0.79 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 15.633 15.633 73.54 +P01112 25 Q C ? P01112 25 Q C ? ? probably damaging alignment ? deleterious 0.995 0.0277 0.681 0.0521 NO NO ? +3.811 -1.351 -5.162 2 225 20 20 6q21 25 D 1.00 171 0.685 T A -36 1.1 0.79 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.156 ? 73.54 +P01112 25 Q D ? P01112 25 Q D ? ? benign alignment ? neutral 0.038 0.175 0.944 0.201 NO NO ? +1.292 -1.351 -2.643 2 225 20 20 6q21 25 D 1.00 171 0.685 T A -33 0.11 0.79 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 29.177 29.177 73.54 +P01112 25 Q E ? P01112 25 Q E C G benign alignment ? neutral 0.071 0.156 0.935 0.185 NO NO ? +0.937 -1.351 -2.288 2 225 20 20 6q21 25 D 1.00 171 0.685 T A -6 0.4 0.79 ? ? ? ? ? ? ? 1 0 2 +39 PF00071.17 13.674 13.674 73.54 +P01112 25 Q F ? P01112 25 Q F ? ? probably damaging alignment ? deleterious 0.997 0.0167 0.409 0.0357 NO NO ? +3.045 -1.351 -4.396 2 225 20 20 6q21 25 D 1.00 171 0.685 T A 46 1.22 0.79 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.190 ? 73.54 +P01112 25 Q G ? P01112 25 Q G ? ? probably damaging alignment ? deleterious 0.965 0.047 0.776 0.0757 NO NO ? +2.070 -1.351 -3.421 2 225 20 20 6q21 25 D 1.00 171 0.685 T A -84 0.35 0.79 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 4.229 ? 73.54 +P01112 25 Q H ? P01112 25 Q H G C probably damaging alignment ? deleterious 0.995 0.0277 0.681 0.0521 NO NO ? +3.076 -1.351 -4.427 2 225 20 20 6q21 25 D 1.00 171 0.685 T A 9 0.47 0.79 ? ? ? ? ? ? ? 1 2 0 +37 PF00071.17 1.308 ? 73.54 +P01112 25 Q I ? P01112 25 Q I ? ? probably damaging alignment ? deleterious 0.957 0.0496 0.784 0.079 NO NO ? +2.740 -1.351 -4.091 2 225 20 20 6q21 25 D 1.00 171 0.685 T A 23 1.12 0.79 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.318 ? 73.54 +P01112 25 Q K ? P01112 25 Q K C A benign alignment ? neutral 0.068 0.158 0.936 0.186 NO NO ? +0.841 -1.351 -2.192 2 225 20 20 6q21 25 D 1.00 171 0.685 T A 24 1.7 0.79 ? ? ? ? ? ? ? 1 0 0 +39 PF00071.17 13.780 13.780 73.54 +P01112 25 Q L ? P01112 25 Q L A T possibly damaging alignment ? deleterious 0.892 0.0636 0.821 0.095 NO NO ? +2.160 -1.351 -3.511 2 225 20 20 6q21 25 D 1.00 171 0.685 T A 23 1.19 0.79 ? ? ? ? ? ? ? 1 1 0 +38 PF00071.17 3.213 ? 73.54 +P01112 25 Q M ? P01112 25 Q M ? ? probably damaging alignment ? deleterious 0.996 0.0222 0.545 0.0439 NO NO ? +3.173 -1.351 -4.524 2 225 20 20 6q21 25 D 1.00 171 0.685 T A 19 1.19 0.79 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 0.975 ? 73.54 +P01112 25 Q N ? P01112 25 Q N ? ? possibly damaging alignment ? deleterious 0.806 0.072 0.842 0.104 NO NO ? +2.227 -1.351 -3.578 2 225 20 20 6q21 25 D 1.00 171 0.685 T A -30 0.0299999999999999 0.79 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 5.102 ? 73.54 +P01112 25 Q P ? P01112 25 Q P A C possibly damaging alignment ? deleterious 0.927 0.0581 0.807 0.0889 NO NO ? +2.441 -1.351 -3.792 2 225 20 20 6q21 25 D 1.00 171 0.685 T A -32 0.12 0.79 ? ? ? ? ? ? ? 1 1 2 +38 PF00071.17 1.697 ? 73.54 +P01112 25 Q R ? P01112 25 Q R A G benign alignment ? neutral 0.099 0.146 0.93 0.175 NO NO ? +1.366 -1.351 -2.717 2 225 20 20 6q21 25 D 1.00 171 0.685 T A 29 0.56 0.79 ? ? ? ? ? ? ? 0 1 2 +38 PF00071.17 17.475 17.475 73.54 +P01112 25 Q S ? P01112 25 Q S ? ? possibly damaging alignment ? deleterious 0.933 0.0573 0.804 0.0882 NO NO ? +1.928 -1.351 -3.279 2 225 20 20 6q21 25 D 1.00 171 0.685 T A -55 0.37 0.79 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 4.547 ? 73.54 +P01112 25 Q T ? P01112 25 Q T ? ? possibly damaging alignment ? deleterious 0.517 0.0961 0.883 0.129 NO NO ? +2.174 -1.351 -3.525 2 225 20 20 6q21 25 D 1.00 171 0.685 T A -28 0.42 0.79 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.704 ? 73.54 +P01112 25 Q V ? P01112 25 Q V ? ? possibly damaging alignment ? deleterious 0.768 0.0762 0.85 0.108 NO NO ? +2.288 -1.351 -3.639 2 225 20 20 6q21 25 D 1.00 171 0.685 T A -4 1.08 0.79 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 3.685 ? 73.54 +P01112 25 Q W ? P01112 25 Q W ? ? probably damaging alignment ? deleterious 0.999 0.00574 0.136 0.0192 NO NO ? +3.984 -1.351 -5.335 2 225 20 20 6q21 25 D 1.00 171 0.685 T A 83 1.11 0.79 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 0.293 ? 73.54 +P01112 25 Q Y ? P01112 25 Q Y ? ? probably damaging alignment ? deleterious 0.997 0.0167 0.409 0.0357 NO NO ? +2.824 -1.351 -4.175 2 225 20 20 6q21 25 D 1.00 171 0.685 T A 49 0.85 0.79 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 0.945 ? 73.54 +P01112 26 N A ? P01112 26 N A ? ? possibly damaging alignment ? deleterious 0.713 0.0812 0.858 0.114 NO NO ? +1.986 -1.308 -3.294 2 225 20 20 6q21 26 D 1.00 171 0.600 S l -26 0.61 0.49 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 7.515 ? 70.90 +P01112 26 N C ? P01112 26 N C ? ? probably damaging alignment ? deleterious 0.999 0.00574 0.136 0.0192 NO NO ? +3.879 -1.308 -5.187 2 225 20 20 6q21 26 D 1.00 171 0.600 S l -6 1.07 0.49 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.254 ? 70.90 +P01112 26 N D ? P01112 26 N D A G benign alignment ? neutral 0.362 0.108 0.898 0.14 NO NO ? +1.398 -1.308 -2.706 2 225 20 20 6q21 26 D 1.00 171 0.600 S l -3 0.14 0.49 ? ? ? ? ? ? ? 0 0 0 +36 PF00071.17 18.262 18.262 70.90 +P01112 26 N E ? P01112 26 N E ? ? probably damaging alignment ? deleterious 0.962 0.0478 0.779 0.0767 NO NO ? +2.012 -1.308 -3.320 2 225 20 20 6q21 26 D 1.00 171 0.600 S l 24 0.43 0.49 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 6.667 ? 70.90 +P01112 26 N F ? P01112 26 N F ? ? probably damaging alignment ? deleterious 0.999 0.00574 0.136 0.0192 NO NO ? +3.070 -1.308 -4.378 2 225 20 20 6q21 26 D 1.00 171 0.600 S l 76 1.19 0.49 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.168 ? 70.90 +P01112 26 N G ? P01112 26 N G ? ? benign alignment ? neutral 0.378 0.107 0.897 0.139 NO NO ? +1.079 -1.308 -2.387 2 225 20 20 6q21 26 D 1.00 171 0.600 S l -54 0.32 0.49 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 36.149 36.149 70.90 +P01112 26 N H ? P01112 26 N H A C possibly damaging alignment ? deleterious 0.684 0.0838 0.862 0.116 NO NO ? +1.843 -1.308 -3.151 2 225 20 20 6q21 26 D 1.00 171 0.600 S l 39 0.44 0.49 ? ? ? ? ? ? ? 1 0 0 +36 PF00071.17 20.043 20.043 70.90 +P01112 26 N I ? P01112 26 N I A T probably damaging alignment ? deleterious 0.964 0.0472 0.777 0.0761 NO NO ? +2.711 -1.308 -4.019 2 225 20 20 6q21 26 D 1.00 171 0.600 S l 53 1.09 0.49 ? ? ? ? ? ? ? 1 1 0 +35 PF00071.17 10.077 ? 70.90 +P01112 26 N K ? P01112 26 N K C G possibly damaging alignment ? deleterious 0.876 0.0651 0.826 0.0966 NO NO ? +1.465 -1.308 -2.773 2 225 20 20 6q21 26 D 1.00 171 0.600 S l 54 1.73 0.49 ? ? ? ? ? ? ? 1 2 0 +34 PF00071.17 18.178 18.178 70.90 +P01112 26 N L ? P01112 26 N L ? ? probably damaging alignment ? deleterious 0.973 0.044 0.765 0.0723 NO NO ? +2.329 -1.308 -3.637 2 225 20 20 6q21 26 D 1.00 171 0.600 S l 53 1.16 0.49 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 7.978 ? 70.90 +P01112 26 N M ? P01112 26 N M ? ? probably damaging alignment ? deleterious 0.998 0.0112 0.273 0.0274 NO NO ? +3.443 -1.308 -4.751 2 225 20 20 6q21 26 D 1.00 171 0.600 S l 49 1.16 0.49 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.946 ? 70.90 +P01112 26 N P ? P01112 26 N P ? ? probably damaging alignment ? deleterious 0.969 0.045 0.77 0.0734 NO NO ? +2.664 -1.308 -3.972 2 225 20 20 6q21 26 D 1.00 171 0.600 S l -2 0.09 0.49 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.003 ? 70.90 +P01112 26 N Q ? P01112 26 N Q ? ? possibly damaging alignment ? deleterious 0.591 0.0926 0.874 0.125 NO NO ? +1.231 -1.308 -2.539 2 225 20 20 6q21 26 D 1.00 171 0.600 S l 30 0.0299999999999999 0.49 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 13.809 13.809 70.90 +P01112 26 N R ? P01112 26 N R ? ? probably damaging alignment ? deleterious 0.99 0.0338 0.719 0.06 NO NO ? +2.375 -1.308 -3.683 2 225 20 20 6q21 26 D 1.00 171 0.600 S l 59 0.59 0.49 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 7.033 ? 70.90 +P01112 26 N S ? P01112 26 N S A G benign alignment ? neutral 0.192 0.127 0.917 0.158 NO NO ? +1.371 -1.308 -2.679 2 225 20 20 6q21 26 D 1.00 171 0.600 S l -25 0.34 0.49 ? ? ? ? ? ? ? 0 1 0 +35 PF00071.17 15.127 15.127 70.90 +P01112 26 N T ? P01112 26 N T A C possibly damaging alignment ? deleterious 0.9 0.0627 0.818 0.0941 NO NO ? +2.150 -1.308 -3.458 2 225 20 20 6q21 26 D 1.00 171 0.600 S l 2 0.39 0.49 ? ? ? ? ? ? ? 1 1 0 +35 PF00071.17 5.649 ? 70.90 +P01112 26 N V ? P01112 26 N V ? ? benign alignment ? neutral 0.227 0.121 0.913 0.152 NO NO ? +1.645 -1.308 -2.953 2 225 20 20 6q21 26 D 1.00 171 0.600 S l 26 1.05 0.49 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 16.524 16.524 70.90 +P01112 26 N W ? P01112 26 N W ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +4.222 -1.308 -5.530 2 225 20 20 6q21 26 D 1.00 171 0.600 S l 113 1.08 0.49 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 0.428 ? 70.90 +P01112 26 N Y ? P01112 26 N Y A T probably damaging alignment ? deleterious 0.998 0.0112 0.273 0.0274 NO NO ? +2.922 -1.308 -4.230 2 225 20 20 6q21 26 D 1.00 171 0.600 S l 79 0.82 0.49 ? ? ? ? ? ? ? 1 0 0 +36 PF00071.17 3.286 ? 70.90 +P01112 27 H A ? P01112 27 H A ? ? possibly damaging alignment ? deleterious 0.875 0.0653 0.826 0.0967 NO NO ? +1.798 -1.550 -3.348 2 225 20 20 6q21 27 D 1.00 171 0.553 S B -65 0.17 0.27 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 4.012 ? 79.89 +P01112 27 H C ? P01112 27 H C ? ? benign alignment ? neutral 0.078 0.154 0.933 0.183 NO NO ? +1.457 -1.550 -3.007 2 225 20 20 6q21 27 D 1.00 171 0.553 S B -45 0.63 0.27 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 24.037 24.037 79.89 +P01112 27 H D ? P01112 27 H D C G possibly damaging alignment ? deleterious 0.848 0.0674 0.834 0.0988 NO NO ? +2.168 -1.550 -3.718 2 225 20 20 6q21 27 D 1.00 171 0.553 S B -42 0.58 0.27 ? ? ? ? ? ? ? 1 0 2 +33 PF00071.17 3.659 ? 79.89 +P01112 27 H E ? P01112 27 H E ? ? possibly damaging alignment ? deleterious 0.836 0.0687 0.836 0.1 NO NO ? +1.899 -1.550 -3.449 2 225 20 20 6q21 27 D 1.00 171 0.553 S B -15 0.87 0.27 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 7.378 ? 79.89 +P01112 27 H F ? P01112 27 H F ? ? possibly damaging alignment ? deleterious 0.872 0.0655 0.827 0.0969 NO NO ? +2.507 -1.550 -4.057 2 225 20 20 6q21 27 D 1.00 171 0.553 S B 37 0.75 0.27 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 5.420 ? 79.89 +P01112 27 H G ? P01112 27 H G ? ? probably damaging alignment ? deleterious 0.961 0.048 0.78 0.077 NO NO ? +2.031 -1.550 -3.581 2 225 20 20 6q21 27 D 1.00 171 0.553 S B -93 0.12 0.27 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.853 ? 79.89 +P01112 27 H I ? P01112 27 H I ? ? benign alignment ? neutral 0.324 0.111 0.903 0.143 NO NO ? +1.517 -1.550 -3.067 2 225 20 20 6q21 27 D 1.00 171 0.553 S B 14 0.65 0.27 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 14.941 14.941 79.89 +P01112 27 H K ? P01112 27 H K ? ? benign alignment ? neutral 0.165 0.131 0.92 0.162 NO NO ? +1.285 -1.550 -2.835 2 225 20 20 6q21 27 D 1.00 171 0.553 S B 15 2.17 0.27 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 14.953 14.953 79.89 +P01112 27 H L ? P01112 27 H L A T benign alignment ? neutral 0.034 0.178 0.946 0.203 NO NO ? +1.269 -1.550 -2.819 2 225 20 20 6q21 27 D 1.00 171 0.553 S B 14 0.72 0.27 ? ? ? ? ? ? ? 1 1 0 +32 PF00071.17 30.002 30.002 79.89 +P01112 27 H M ? P01112 27 H M ? ? probably damaging alignment ? deleterious 0.974 0.0438 0.763 0.0722 NO NO ? +3.091 -1.550 -4.641 2 225 20 20 6q21 27 D 1.00 171 0.553 S B 10 0.72 0.27 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 3.982 ? 79.89 +P01112 27 H N ? P01112 27 H N C A benign alignment ? neutral 0.101 0.145 0.929 0.174 NO NO ? +1.342 -1.550 -2.892 2 225 20 20 6q21 27 D 1.00 171 0.553 S B -39 0.44 0.27 ? ? ? ? ? ? ? 1 0 0 +33 PF00071.17 13.909 13.909 79.89 +P01112 27 H P ? P01112 27 H P A C possibly damaging alignment ? deleterious 0.919 0.0594 0.811 0.0903 NO NO ? +2.523 -1.550 -4.073 2 225 20 20 6q21 27 D 1.00 171 0.553 S B -41 0.35 0.27 ? ? ? ? ? ? ? 1 1 0 +32 PF00071.17 1.765 ? 79.89 +P01112 27 H Q ? P01112 27 H Q T G benign alignment ? neutral 0.135 0.138 0.924 0.168 NO NO ? +1.037 -1.550 -2.587 2 225 20 20 6q21 27 D 1.00 171 0.553 S B -9 0.47 0.27 ? ? ? ? ? ? ? 1 2 0 +31 PF00071.17 15.281 15.281 79.89 +P01112 27 H R ? P01112 27 H R A G benign alignment ? neutral 0.061 0.161 0.938 0.188 NO NO ? +0.967 -1.550 -2.517 2 225 20 20 6q21 27 D 1.00 171 0.553 S B 20 1.03 0.27 ? ? ? ? ? ? ? 0 1 2 +32 PF00071.17 18.021 18.021 79.89 +P01112 27 H S ? P01112 27 H S ? ? probably damaging alignment ? deleterious 0.961 0.048 0.78 0.077 NO NO ? +1.980 -1.550 -3.530 2 225 20 20 6q21 27 D 1.00 171 0.553 S B -64 0.1 0.27 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 3.947 ? 79.89 +P01112 27 H T ? P01112 27 H T ? ? possibly damaging alignment ? deleterious 0.88 0.0647 0.824 0.0961 NO NO ? +2.137 -1.550 -3.687 2 225 20 20 6q21 27 D 1.00 171 0.553 S B -37 0.05 0.27 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.877 ? 79.89 +P01112 27 H V ? P01112 27 H V ? ? possibly damaging alignment ? deleterious 0.836 0.0687 0.836 0.1 NO NO ? +2.073 -1.550 -3.623 2 225 20 20 6q21 27 D 1.00 171 0.553 S B -13 0.61 0.27 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 9.700 ? 79.89 +P01112 27 H W ? P01112 27 H W ? ? probably damaging alignment ? deleterious 0.999 0.00574 0.136 0.0192 NO NO ? +3.716 -1.550 -5.266 2 225 20 20 6q21 27 D 1.00 171 0.553 S B 74 0.64 0.27 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.135 ? 79.89 +P01112 27 H Y ? P01112 27 H Y C T possibly damaging alignment ? deleterious 0.595 0.0919 0.874 0.125 NO NO ? +1.420 -1.550 -2.970 2 225 20 20 6q21 27 D 1.00 171 0.553 S B 40 0.38 0.27 ? ? ? ? ? ? ? 0 0 0 +33 PF00071.17 13.099 13.099 79.89 +P01112 28 F A ? P01112 28 F A ? ? probably damaging alignment ? deleterious 0.999 0.00574 0.136 0.0192 NO NO ? +2.385 -0.940 -3.325 2 226 20 20 6q21 28 D 1.00 171 0.432 . b -102 0.58 0.40 ? 1 3.820 ? ? ? ? ? ? ? ? PF00071.17 4.431 ? 68.78 +P01112 28 F C ? P01112 28 F C T G probably damaging alignment ? deleterious 0.971 0.0444 0.768 0.0727 NO NO ? +2.081 -0.940 -3.021 2 226 20 20 6q21 28 D 1.00 171 0.432 . b -82 0.12 0.40 ? 1 3.820 ? ? ? ? 1 1 0 +29 PF00071.17 33.243 33.243 68.78 +P01112 28 F D ? P01112 28 F D ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.052 -0.940 -3.992 2 226 20 20 6q21 28 D 1.00 171 0.432 . b -79 1.33 0.40 ? 1 3.820 ? ? ? ? ? ? ? ? PF00071.17 1.112 ? 68.78 +P01112 28 F E ? P01112 28 F E ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.018 -0.940 -3.958 2 226 20 20 6q21 28 D 1.00 171 0.432 . b -52 1.62 0.40 ? 1 3.820 ? ? ? ? ? ? ? ? PF00071.17 1.370 ? 68.78 +P01112 28 F G ? P01112 28 F G ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.716 -0.940 -3.656 2 226 20 20 6q21 28 D 1.00 171 0.432 . b -130 0.87 0.40 ? 1 3.820 ? ? ? ? ? ? ? ? PF00071.17 2.144 ? 68.78 +P01112 28 F H ? P01112 28 F H ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.534 -0.940 -4.474 2 226 20 20 6q21 28 D 1.00 171 0.432 . b -37 0.75 0.40 ? 1 3.820 ? ? ? ? ? ? ? ? PF00071.17 2.394 ? 68.78 +P01112 28 F I ? P01112 28 F I T A probably damaging alignment ? deleterious 0.997 0.0167 0.409 0.0357 NO NO ? +2.506 -0.940 -3.446 2 226 20 20 6q21 28 D 1.00 171 0.432 . b -23 0.1 0.40 ? 1 3.820 ? ? ? ? 1 0 0 +30 PF00071.17 3.053 ? 68.78 +P01112 28 F K ? P01112 28 F K ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.017 -0.940 -3.957 2 226 20 20 6q21 28 D 1.00 171 0.432 . b -22 2.92 0.40 ? 1 3.820 ? ? ? ? ? ? ? ? PF00071.17 1.572 ? 68.78 +P01112 28 F L ? P01112 28 F L T C probably damaging alignment ? deleterious 0.997 0.0167 0.409 0.0357 NO NO ? +2.079 -0.940 -3.019 2 226 20 20 6q21 28 D 1.00 171 0.432 . b -23 0.03 0.40 ? 1 3.820 ? ? ? ? 0 0 0 +30 PF00071.17 4.370 ? 68.78 +P01112 28 F M ? P01112 28 F M ? ? probably damaging alignment ? deleterious 0.999 0.00574 0.136 0.0192 NO NO ? +3.426 -0.940 -4.366 2 226 20 20 6q21 28 D 1.00 171 0.432 . b -27 0.03 0.40 ? 1 3.820 ? ? ? ? ? ? ? ? PF00071.17 1.051 ? 68.78 +P01112 28 F N ? P01112 28 F N ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.233 -0.940 -4.173 2 226 20 20 6q21 28 D 1.00 171 0.432 . b -76 1.19 0.40 ? 1 3.820 ? ? ? ? ? ? ? ? PF00071.17 1.222 ? 68.78 +P01112 28 F P ? P01112 28 F P ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.417 -0.940 -4.357 2 226 20 20 6q21 28 D 1.00 171 0.432 . b -78 1.1 0.40 ? 1 3.820 ? ? ? ? ? ? ? ? PF00071.17 1.006 ? 68.78 +P01112 28 F Q ? P01112 28 F Q ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.432 -0.940 -4.372 2 226 20 20 6q21 28 D 1.00 171 0.432 . b -46 1.22 0.40 ? 1 3.820 ? ? ? ? ? ? ? ? PF00071.17 1.063 ? 68.78 +P01112 28 F R ? P01112 28 F R ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.268 -0.940 -4.208 2 226 20 20 6q21 28 D 1.00 171 0.432 . b -17 1.78 0.40 ? 1 3.820 ? ? ? ? ? ? ? ? PF00071.17 1.458 ? 68.78 +P01112 28 F S ? P01112 28 F S T C probably damaging alignment ? deleterious 0.999 0.00574 0.136 0.0192 NO NO ? +2.721 -0.940 -3.661 2 226 20 20 6q21 28 D 1.00 171 0.432 . b -101 0.85 0.40 ? 1 3.820 ? ? ? ? 0 1 0 +29 PF00071.17 2.907 ? 68.78 +P01112 28 F T ? P01112 28 F T ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.757 -0.940 -3.697 2 226 20 20 6q21 28 D 1.00 171 0.432 . b -74 0.8 0.40 ? 1 3.820 ? ? ? ? ? ? ? ? PF00071.17 2.592 ? 68.78 +P01112 28 F V ? P01112 28 F V T G probably damaging alignment ? deleterious 0.996 0.0222 0.545 0.0439 NO NO ? +2.437 -0.940 -3.377 2 226 20 20 6q21 28 D 1.00 171 0.432 . b -50 0.14 0.40 ? 1 3.820 ? ? ? ? 1 0 0 +30 PF00071.17 3.791 ? 68.78 +P01112 28 F W ? P01112 28 F W ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.578 -0.940 -4.518 2 226 20 20 6q21 28 D 1.00 171 0.432 . b 37 0.11 0.40 ? 1 3.820 ? ? ? ? ? ? ? ? PF00071.17 1.396 ? 68.78 +P01112 28 F Y ? P01112 28 F Y T A possibly damaging alignment ? deleterious 0.884 0.0642 0.823 0.0956 NO NO ? +1.559 -0.940 -2.499 2 226 20 20 6q21 28 D 1.00 171 0.432 . b 3 0.37 0.40 ? 1 3.820 ? ? ? ? 1 1 0 +29 PF00071.17 16.122 16.122 68.78 +P01112 29 V A ? P01112 29 V A T C probably damaging alignment ? deleterious 0.981 0.0399 0.75 0.0672 NO NO ? +1.853 -1.240 -3.093 2 226 20 20 6q21 29 D 1.00 171 0.333 . B -52 0.44 0.49 ? ? ? ? ? ? ? 0 1 2 +26 PF00071.17 3.328 ? 70.90 +P01112 29 V C ? P01112 29 V C ? ? probably damaging alignment ? deleterious 0.999 0.00574 0.136 0.0192 NO NO ? +3.548 -1.240 -4.788 2 226 20 20 6q21 29 D 1.00 171 0.333 . B -32 0.02 0.49 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.144 ? 70.90 +P01112 29 V D ? P01112 29 V D ? ? possibly damaging alignment ? deleterious 0.656 0.0869 0.865 0.12 NO NO ? +1.651 -1.240 -2.891 2 226 20 20 6q21 29 D 1.00 171 0.333 . B -29 1.19 0.49 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 24.349 24.349 70.90 +P01112 29 V E ? P01112 29 V E T A possibly damaging alignment ? deleterious 0.91 0.0609 0.814 0.092 NO NO ? +2.510 -1.240 -3.750 2 226 20 20 6q21 29 D 1.00 171 0.333 . B -2 1.48 0.49 ? ? ? ? ? ? ? 1 1 0 +26 PF00071.17 5.626 ? 70.90 +P01112 29 V F ? P01112 29 V F ? ? probably damaging alignment ? deleterious 0.992 0.0314 0.704 0.0568 NO NO ? +2.652 -1.240 -3.892 2 226 20 20 6q21 29 D 1.00 171 0.333 . B 50 0.14 0.49 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 3.215 ? 70.90 +P01112 29 V G ? P01112 29 V G T G probably damaging alignment ? deleterious 0.994 0.0289 0.689 0.0537 NO NO ? +2.494 -1.240 -3.734 2 226 20 20 6q21 29 D 1.00 171 0.333 . B -80 0.73 0.49 ? ? ? ? ? ? ? 1 1 0 +26 PF00071.17 2.887 ? 70.90 +P01112 29 V H ? P01112 29 V H ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.730 -1.240 -4.970 2 226 20 20 6q21 29 D 1.00 171 0.333 . B 13 0.61 0.49 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.092 ? 70.90 +P01112 29 V I ? P01112 29 V I ? ? benign alignment ? neutral 0.009 0.233 0.961 0.247 NO NO ? +0.647 -1.240 -1.887 2 226 20 20 6q21 29 D 1.00 171 0.333 . B 27 0.04 0.49 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 19.251 19.251 70.90 +P01112 29 V K ? P01112 29 V K ? ? probably damaging alignment ? deleterious 0.983 0.0387 0.745 0.0657 NO NO ? +2.575 -1.240 -3.815 2 226 20 20 6q21 29 D 1.00 171 0.333 . B 28 2.78 0.49 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.799 ? 70.90 +P01112 29 V L ? P01112 29 V L G C benign alignment ? neutral 0.016 0.207 0.955 0.227 NO NO ? +0.939 -1.240 -2.179 2 226 20 20 6q21 29 D 1.00 171 0.333 . B 27 0.11 0.49 ? ? ? ? ? ? ? 1 0 0 +27 PF00071.17 22.054 22.054 70.90 +P01112 29 V M ? P01112 29 V M G A possibly damaging alignment ? deleterious 0.906 0.0617 0.816 0.093 NO NO ? +1.818 -1.240 -3.058 2 226 20 20 6q21 29 D 1.00 171 0.333 . B 23 0.11 0.49 ? ? ? ? ? ? ? 0 0 0 +27 PF00071.17 7.284 7.284 70.90 +P01112 29 V N ? P01112 29 V N ? ? probably damaging alignment ? deleterious 0.97 0.0446 0.769 0.0728 NO NO ? +2.888 -1.240 -4.128 2 226 20 20 6q21 29 D 1.00 171 0.333 . B -26 1.05 0.49 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 4.258 ? 70.90 +P01112 29 V P ? P01112 29 V P ? ? probably damaging alignment ? deleterious 0.995 0.0277 0.681 0.0521 NO NO ? +2.814 -1.240 -4.054 2 226 20 20 6q21 29 D 1.00 171 0.333 . B -28 0.96 0.49 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.416 ? 70.90 +P01112 29 V Q ? P01112 29 V Q ? ? probably damaging alignment ? deleterious 0.997 0.0167 0.409 0.0357 NO NO ? +2.971 -1.240 -4.211 2 226 20 20 6q21 29 D 1.00 171 0.333 . B 4 1.08 0.49 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.886 ? 70.90 +P01112 29 V R ? P01112 29 V R ? ? probably damaging alignment ? deleterious 0.999 0.00574 0.136 0.0192 NO NO ? +2.957 -1.240 -4.197 2 226 20 20 6q21 29 D 1.00 171 0.333 . B 33 1.64 0.49 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.816 ? 70.90 +P01112 29 V S ? P01112 29 V S ? ? probably damaging alignment ? deleterious 0.985 0.0375 0.74 0.0643 NO NO ? +2.436 -1.240 -3.676 2 226 20 20 6q21 29 D 1.00 171 0.333 . B -51 0.71 0.49 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 3.209 ? 70.90 +P01112 29 V T ? P01112 29 V T ? ? probably damaging alignment ? deleterious 0.965 0.047 0.776 0.0757 NO NO ? +2.183 -1.240 -3.423 2 226 20 20 6q21 29 D 1.00 171 0.333 . B -24 0.66 0.49 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.814 ? 70.90 +P01112 29 V W ? P01112 29 V W ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +4.153 -1.240 -5.393 2 226 20 20 6q21 29 D 1.00 171 0.333 . B 87 0.03 0.49 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 0.435 ? 70.90 +P01112 29 V Y ? P01112 29 V Y ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.848 -1.240 -4.088 2 226 20 20 6q21 29 D 1.00 171 0.333 . B 53 0.23 0.49 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.443 ? 70.90 +P01112 30 D A ? P01112 30 D A A C benign alignment ? neutral 0.041 0.172 0.943 0.199 NO NO ? +0.932 -1.567 -2.499 2 226 20 20 6q21 30 D 1.00 171 0.598 . a -23 0.75 1.34 ? 1 2.654 ? ? ? ? 1 1 0 +23 PF00071.17 18.851 18.851 78.84 +P01112 30 D C ? P01112 30 D C ? ? probably damaging structure 2.2.3 deleterious 0.977 0.0424 0.758 0.0704 NO NO ? +3.539 -1.567 -5.106 2 226 20 20 6q21 30 D 1.00 171 0.598 . a -3 1.21 1.34 ? 1 2.654 ? ? ? ? ? ? ? ? PF00071.17 1.395 ? 78.84 +P01112 30 D E ? P01112 30 D E C G benign alignment ? neutral 0.001 0.852 0.994 0.514 NO NO ? +0.486 -1.567 -2.053 2 226 20 20 6q21 30 D 1.00 171 0.598 . a 27 0.29 1.34 ? 1 2.654 ? ? ? ? 1 2 1 +22 PF00071.17 23.419 23.419 78.84 +P01112 30 D F ? P01112 30 D F ? ? probably damaging structure 2.2.3 deleterious 0.994 0.0289 0.689 0.0537 NO NO ? +2.797 -1.567 -4.364 2 226 20 20 6q21 30 D 1.00 171 0.598 . a 79 1.33 1.34 ? 1 2.654 ? ? ? ? ? ? ? ? PF00071.17 2.524 ? 78.84 +P01112 30 D G ? P01112 30 D G A G possibly damaging structure 2.2.3 deleterious 0.638 0.0888 0.867 0.122 NO NO ? +1.862 -1.567 -3.429 2 226 20 20 6q21 30 D 1.00 171 0.598 . a -51 0.46 1.34 ? 1 2.654 ? ? ? ? 0 1 0 +23 PF00071.17 5.100 ? 78.84 +P01112 30 D H ? P01112 30 D H G C benign structure 2.2.3 neutral 0.242 0.12 0.912 0.151 NO NO ? +1.697 -1.567 -3.264 2 226 20 20 6q21 30 D 1.00 171 0.598 . a 42 0.58 1.34 ? 1 2.654 ? ? ? ? 1 0 0 +24 PF00071.17 14.611 14.611 78.84 +P01112 30 D I ? P01112 30 D I ? ? possibly damaging structure 2.2.3 deleterious 0.92 0.0592 0.81 0.0901 NO NO ? +2.356 -1.567 -3.923 2 226 20 20 6q21 30 D 1.00 171 0.598 . a 56 1.23 1.34 ? 1 2.654 ? ? ? ? ? ? ? ? PF00071.17 11.728 ? 78.84 +P01112 30 D K ? P01112 30 D K ? ? possibly damaging structure 2.2.3 deleterious 0.92 0.0592 0.81 0.0901 NO NO ? +1.960 -1.567 -3.527 2 226 20 20 6q21 30 D 1.00 171 0.598 . a 57 1.59 1.34 ? 1 2.654 ? ? ? ? ? ? ? ? PF00071.17 7.126 ? 78.84 +P01112 30 D L ? P01112 30 D L ? ? possibly damaging structure 2.2.3 deleterious 0.92 0.0592 0.81 0.0901 NO NO ? +2.035 -1.567 -3.602 2 226 20 20 6q21 30 D 1.00 171 0.598 . a 56 1.3 1.34 ? 1 2.654 ? ? ? ? ? ? ? ? PF00071.17 9.285 ? 78.84 +P01112 30 D M ? P01112 30 D M ? ? probably damaging structure 2.2.3 deleterious 0.985 0.0375 0.74 0.0643 NO NO ? +3.239 -1.567 -4.806 2 226 20 20 6q21 30 D 1.00 171 0.598 . a 52 1.3 1.34 ? 1 2.654 ? ? ? ? ? ? ? ? PF00071.17 2.265 ? 78.84 +P01112 30 D N ? P01112 30 D N G A possibly damaging structure 2.2.3 deleterious 0.684 0.0838 0.862 0.116 NO NO ? +2.048 -1.567 -3.615 2 226 20 20 6q21 30 D 1.00 171 0.598 . a 3 0.14 1.34 ? 1 2.654 ? ? ? ? 0 0 0 +24 PF00071.17 3.522 ? 78.84 +P01112 30 D P ? P01112 30 D P ? ? benign structure 2.2.3 neutral 0.005 0.26 0.968 0.267 NO NO ? +1.382 -1.567 -2.949 2 226 20 20 6q21 30 D 1.00 171 0.598 . a 1 0.23 1.34 ? 1 2.654 ? ? ? ? ? ? ? ? PF00071.17 24.606 24.606 78.84 +P01112 30 D Q ? P01112 30 D Q ? ? benign structure 2.2.3 neutral 0.298 0.114 0.906 0.145 NO NO ? +1.446 -1.567 -3.013 2 226 20 20 6q21 30 D 1.00 171 0.598 . a 33 0.11 1.34 ? 1 2.654 ? ? ? ? ? ? ? ? PF00071.17 16.866 16.866 78.84 +P01112 30 D R ? P01112 30 D R ? ? possibly damaging structure 2.2.3 deleterious 0.92 0.0592 0.81 0.0901 NO NO ? +2.333 -1.567 -3.900 2 226 20 20 6q21 30 D 1.00 171 0.598 . a 62 0.45 1.34 ? 1 2.654 ? ? ? ? ? ? ? ? PF00071.17 5.720 ? 78.84 +P01112 30 D S ? P01112 30 D S ? ? possibly damaging structure 2.2.3 neutral 0.479 0.0986 0.886 0.131 NO NO ? +1.756 -1.567 -3.323 2 226 20 20 6q21 30 D 1.00 171 0.598 . a -22 0.48 1.34 ? 1 2.654 ? ? ? ? ? ? ? ? PF00071.17 5.962 ? 78.84 +P01112 30 D T ? P01112 30 D T ? ? benign alignment ? neutral 0.011 0.222 0.959 0.239 NO NO ? +0.556 -1.567 -2.123 2 226 20 20 6q21 30 D 1.00 171 0.598 . a 5 0.53 1.34 ? 1 2.654 ? ? ? ? ? ? ? ? PF00071.17 15.874 15.874 78.84 +P01112 30 D V ? P01112 30 D V A T benign structure 2.2.3 neutral 0.014 0.212 0.956 0.231 NO NO ? +1.328 -1.567 -2.895 2 226 20 20 6q21 30 D 1.00 171 0.598 . a 29 1.19 1.34 ? 1 2.654 ? ? ? ? 1 1 0 +23 PF00071.17 19.231 19.231 78.84 +P01112 30 D W ? P01112 30 D W ? ? probably damaging structure 2.2.3 deleterious 0.998 0.0112 0.273 0.0274 NO NO ? +3.945 -1.567 -5.512 2 226 20 20 6q21 30 D 1.00 171 0.598 . a 116 1.22 1.34 ? 1 2.654 ? ? ? ? ? ? ? ? PF00071.17 0.523 ? 78.84 +P01112 30 D Y ? P01112 30 D Y G T probably damaging structure 2.2.3 deleterious 0.993 0.0301 0.696 0.0553 NO NO ? +2.747 -1.567 -4.314 2 226 20 20 6q21 30 D 1.00 171 0.598 . a 82 0.96 1.34 ? 1 2.654 ? ? ? ? 1 0 0 +24 PF00071.17 2.395 ? 78.84 +P01112 31 E A ? P01112 31 E A A C benign alignment ? neutral 0.347 0.109 0.9 0.141 NO NO ? +1.428 -1.093 -2.521 2 226 20 18 6q21 31 D 1.00 171 0.818 T a -50 1.04 1.70 ? 1 5.099 ? ? ? ? 1 1 0 +20 PF00071.17 23.755 23.755 82.01 +P01112 31 E C ? P01112 31 E C ? ? probably damaging alignment ? deleterious 0.998 0.0112 0.273 0.0274 NO NO ? +4.098 -1.093 -5.191 2 226 20 18 6q21 31 D 1.00 171 0.818 T a -30 1.5 1.70 ? 1 5.099 ? ? ? ? ? ? ? ? PF00071.17 1.757 ? 82.01 +P01112 31 E D ? P01112 31 E D A C benign alignment ? neutral 0.027 0.186 0.948 0.21 NO NO ? +1.155 -1.093 -2.248 2 226 20 18 6q21 31 D 1.00 171 0.818 T a -27 0.29 1.70 ? 1 5.099 ? ? ? ? 1 2 0 +19 PF00071.17 24.769 24.769 82.01 +P01112 31 E F ? P01112 31 E F ? ? probably damaging alignment ? deleterious 0.998 0.0112 0.273 0.0274 NO NO ? +3.235 -1.093 -4.328 2 226 20 18 6q21 31 D 1.00 171 0.818 T a 52 1.62 1.70 ? 1 5.099 ? ? ? ? ? ? ? ? PF00071.17 2.823 ? 82.01 +P01112 31 E G ? P01112 31 E G A G probably damaging alignment ? deleterious 0.987 0.036 0.731 0.0626 NO NO ? +2.307 -1.093 -3.400 2 226 20 18 6q21 31 D 1.00 171 0.818 T a -78 0.75 1.70 ? 1 5.099 ? ? ? ? 0 1 0 +20 PF00071.17 6.427 ? 82.01 +P01112 31 E H ? P01112 31 E H ? ? probably damaging alignment ? deleterious 0.999 0.00574 0.136 0.0192 NO NO ? +3.336 -1.093 -4.429 2 226 20 18 6q21 31 D 1.00 171 0.818 T a 15 0.87 1.70 ? 1 5.099 ? ? ? ? ? ? ? ? PF00071.17 1.345 ? 82.01 +P01112 31 E I ? P01112 31 E I ? ? probably damaging alignment ? deleterious 0.99 0.0338 0.719 0.06 NO NO ? +2.772 -1.093 -3.865 2 226 20 18 6q21 31 D 1.00 171 0.818 T a 29 1.52 1.70 ? 1 5.099 ? ? ? ? ? ? ? ? PF00071.17 13.118 ? 82.01 +P01112 31 E K ? P01112 31 E K G A probably damaging alignment ? deleterious 0.998 0.0112 0.273 0.0274 NO NO ? +2.135 -1.093 -3.228 2 226 20 18 6q21 31 D 1.00 171 0.818 T a 30 1.3 1.70 ? 1 5.099 ? ? ? ? 0 0 1 +21 PF00071.17 3.970 ? 82.01 +P01112 31 E L ? P01112 31 E L ? ? probably damaging alignment ? deleterious 0.964 0.0472 0.777 0.0761 NO NO ? +2.442 -1.093 -3.535 2 226 20 18 6q21 31 D 1.00 171 0.818 T a 29 1.59 1.70 ? 1 5.099 ? ? ? ? ? ? ? ? PF00071.17 10.385 ? 82.01 +P01112 31 E M ? P01112 31 E M ? ? probably damaging alignment ? deleterious 0.986 0.0368 0.736 0.0634 NO NO ? +3.599 -1.093 -4.692 2 226 20 18 6q21 31 D 1.00 171 0.818 T a 25 1.59 1.70 ? 1 5.099 ? ? ? ? ? ? ? ? PF00071.17 2.534 ? 82.01 +P01112 31 E N ? P01112 31 E N ? ? probably damaging alignment ? deleterious 0.961 0.048 0.78 0.077 NO NO ? +2.495 -1.093 -3.588 2 226 20 18 6q21 31 D 1.00 171 0.818 T a -24 0.43 1.70 ? 1 5.099 ? ? ? ? ? ? ? ? PF00071.17 4.331 ? 82.01 +P01112 31 E P ? P01112 31 E P ? ? possibly damaging alignment ? deleterious 0.941 0.0556 0.799 0.0862 NO NO ? +2.679 -1.093 -3.772 2 226 20 18 6q21 31 D 1.00 171 0.818 T a -26 0.52 1.70 ? 1 5.099 ? ? ? ? ? ? ? ? PF00071.17 2.383 ? 82.01 +P01112 31 E Q ? P01112 31 E Q G C probably damaging alignment ? deleterious 0.957 0.0496 0.784 0.079 NO NO ? +1.627 -1.093 -2.720 2 226 20 18 6q21 31 D 1.00 171 0.818 T a 6 0.4 1.70 ? 1 5.099 ? ? ? ? 1 0 1 +21 PF00071.17 9.395 9.395 82.01 +P01112 31 E R ? P01112 31 E R ? ? probably damaging alignment ? deleterious 0.991 0.0326 0.711 0.0584 NO NO ? +2.574 -1.093 -3.667 2 226 20 18 6q21 31 D 1.00 171 0.818 T a 35 0.16 1.70 ? 1 5.099 ? ? ? ? ? ? ? ? PF00071.17 3.186 ? 82.01 +P01112 31 E S ? P01112 31 E S ? ? probably damaging alignment ? deleterious 0.968 0.0455 0.772 0.074 NO NO ? +2.177 -1.093 -3.270 2 226 20 18 6q21 31 D 1.00 171 0.818 T a -49 0.77 1.70 ? 1 5.099 ? ? ? ? ? ? ? ? PF00071.17 6.909 ? 82.01 +P01112 31 E T ? P01112 31 E T ? ? probably damaging alignment ? deleterious 0.988 0.0353 0.727 0.0617 NO NO ? +2.389 -1.093 -3.482 2 226 20 18 6q21 31 D 1.00 171 0.818 T a -22 0.82 1.70 ? 1 5.099 ? ? ? ? ? ? ? ? PF00071.17 4.109 ? 82.01 +P01112 31 E V ? P01112 31 E V A T benign alignment ? neutral 0.246 0.119 0.911 0.15 NO NO ? +1.638 -1.093 -2.731 2 226 20 18 6q21 31 D 1.00 171 0.818 T a 2 1.48 1.70 ? 1 5.099 ? ? ? ? 1 1 0 +20 PF00071.17 21.510 21.510 82.01 +P01112 31 E W ? P01112 31 E W ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +4.334 -1.093 -5.427 2 226 20 18 6q21 31 D 1.00 171 0.818 T a 89 1.51 1.70 ? 1 5.099 ? ? ? ? ? ? ? ? PF00071.17 0.445 ? 82.01 +P01112 31 E Y ? P01112 31 E Y ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.154 -1.093 -4.247 2 226 20 18 6q21 31 D 1.00 171 0.818 T a 55 1.25 1.70 ? 1 5.099 ? ? ? ? ? ? ? ? PF00071.17 1.697 ? 82.01 +P01112 32 Y A ? P01112 32 Y A ? ? probably damaging alignment ? deleterious 0.999 0.00574 0.136 0.0192 NO NO ? +2.376 -0.973 -3.349 2 227 20 20 6q21 32 D 1.00 171 0.293 T A -105 0.21 1.46 ? 1 4.963 ? ? ? ? ? ? ? ? PF00071.17 4.226 ? 78.31 +P01112 32 Y C ? P01112 32 Y C A G probably damaging alignment ? deleterious 0.974 0.0438 0.763 0.0722 NO NO ? +2.108 -0.973 -3.081 2 227 20 20 6q21 32 D 1.00 171 0.293 T A -85 0.25 1.46 ? 1 4.963 ? ? ? ? 0 1 0 +17 PF00071.17 31.708 31.708 78.31 +P01112 32 Y D ? P01112 32 Y D T G probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.992 -0.973 -3.965 2 227 20 20 6q21 32 D 1.00 171 0.293 T A -82 0.96 1.46 ? 1 4.963 ? ? ? ? 1 0 0 +18 PF00071.17 2.599 ? 78.31 +P01112 32 Y E ? P01112 32 Y E ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.784 -0.973 -3.757 2 227 20 20 6q21 32 D 1.00 171 0.293 T A -55 1.25 1.46 ? 1 4.963 ? ? ? ? ? ? ? ? PF00071.17 3.724 ? 78.31 +P01112 32 Y F ? P01112 32 Y F A T possibly damaging alignment ? deleterious 0.56 0.0942 0.877 0.127 NO NO ? +1.560 -0.973 -2.533 2 227 20 20 6q21 32 D 1.00 171 0.293 T A -3 0.37 1.46 ? 1 4.963 ? ? ? ? 1 1 0 +17 PF00071.17 30.184 30.184 78.31 +P01112 32 Y G ? P01112 32 Y G ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.682 -0.973 -3.655 2 227 20 20 6q21 32 D 1.00 171 0.293 T A -133 0.5 1.46 ? 1 4.963 ? ? ? ? ? ? ? ? PF00071.17 2.611 ? 78.31 +P01112 32 Y H ? P01112 32 Y H T C possibly damaging alignment ? deleterious 0.918 0.0596 0.811 0.0905 NO NO ? +1.904 -0.973 -2.877 2 227 20 20 6q21 32 D 1.00 171 0.293 T A -40 0.38 1.46 ? 1 4.963 ? ? ? ? 0 0 0 +18 PF00071.17 25.288 25.288 78.31 +P01112 32 Y I ? P01112 32 Y I ? ? probably damaging alignment ? deleterious 0.96 0.0483 0.781 0.0774 NO NO ? +2.690 -0.973 -3.663 2 227 20 20 6q21 32 D 1.00 171 0.293 T A -26 0.27 1.46 ? 1 4.963 ? ? ? ? ? ? ? ? PF00071.17 5.030 ? 78.31 +P01112 32 Y K ? P01112 32 Y K ? ? probably damaging alignment ? deleterious 0.998 0.0112 0.273 0.0274 NO NO ? +2.815 -0.973 -3.788 2 227 20 20 6q21 32 D 1.00 171 0.293 T A -25 2.55 1.46 ? 1 4.963 ? ? ? ? ? ? ? ? PF00071.17 3.235 ? 78.31 +P01112 32 Y L ? P01112 32 Y L ? ? probably damaging alignment ? deleterious 0.96 0.0483 0.781 0.0774 NO NO ? +2.262 -0.973 -3.235 2 227 20 20 6q21 32 D 1.00 171 0.293 T A -26 0.34 1.46 ? 1 4.963 ? ? ? ? ? ? ? ? PF00071.17 8.943 ? 78.31 +P01112 32 Y M ? P01112 32 Y M ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.596 -0.973 -4.569 2 227 20 20 6q21 32 D 1.00 171 0.293 T A -30 0.34 1.46 ? 1 4.963 ? ? ? ? ? ? ? ? PF00071.17 1.965 ? 78.31 +P01112 32 Y N ? P01112 32 Y N T A probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.972 -0.973 -3.945 2 227 20 20 6q21 32 D 1.00 171 0.293 T A -79 0.82 1.46 ? 1 4.963 ? ? ? ? 1 0 0 +18 PF00071.17 3.897 ? 78.31 +P01112 32 Y P ? P01112 32 Y P ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.220 -0.973 -4.193 2 227 20 20 6q21 32 D 1.00 171 0.293 T A -81 0.73 1.46 ? 1 4.963 ? ? ? ? ? ? ? ? PF00071.17 1.302 ? 78.31 +P01112 32 Y Q ? P01112 32 Y Q ? ? probably damaging alignment ? deleterious 0.999 0.00574 0.136 0.0192 NO NO ? +3.060 -0.973 -4.033 2 227 20 20 6q21 32 D 1.00 171 0.293 T A -49 0.85 1.46 ? 1 4.963 ? ? ? ? ? ? ? ? PF00071.17 2.858 ? 78.31 +P01112 32 Y R ? P01112 32 Y R ? ? probably damaging alignment ? deleterious 0.999 0.00574 0.136 0.0192 NO NO ? +3.039 -0.973 -4.012 2 227 20 20 6q21 32 D 1.00 171 0.293 T A -20 1.41 1.46 ? 1 4.963 ? ? ? ? ? ? ? ? PF00071.17 3.381 ? 78.31 +P01112 32 Y S ? P01112 32 Y S A C probably damaging alignment ? deleterious 0.999 0.00574 0.136 0.0192 NO NO ? +2.689 -0.973 -3.662 2 227 20 20 6q21 32 D 1.00 171 0.293 T A -104 0.48 1.46 ? 1 4.963 ? ? ? ? 1 1 0 +17 PF00071.17 3.012 ? 78.31 +P01112 32 Y T ? P01112 32 Y T ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.745 -0.973 -3.718 2 227 20 20 6q21 32 D 1.00 171 0.293 T A -77 0.43 1.46 ? 1 4.963 ? ? ? ? ? ? ? ? PF00071.17 2.473 ? 78.31 +P01112 32 Y V ? P01112 32 Y V ? ? probably damaging alignment ? deleterious 0.999 0.00574 0.136 0.0192 NO NO ? +2.455 -0.973 -3.428 2 227 20 20 6q21 32 D 1.00 171 0.293 T A -53 0.23 1.46 ? 1 4.963 ? ? ? ? ? ? ? ? PF00071.17 4.255 ? 78.31 +P01112 32 Y W ? P01112 32 Y W ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.441 -0.973 -4.414 2 227 20 20 6q21 32 D 1.00 171 0.293 T A 34 0.26 1.46 ? 1 4.963 ? ? ? ? ? ? ? ? PF00071.17 1.402 ? 78.31 +P01112 33 D A ? P01112 33 D A A C probably damaging alignment ? deleterious 0.995 0.0277 0.681 0.0521 NO NO ? +2.342 -0.970 -3.312 2 227 20 20 6q21 33 D 1.00 171 0.549 . . -23 0.75 2.11 ? 1 3.166 ? ? ? ? 1 1 0 +14 PF00071.17 4.431 ? 68.78 +P01112 33 D C ? P01112 33 D C ? ? possibly damaging alignment ? deleterious 0.762 0.0768 0.851 0.109 NO NO ? +2.194 -0.970 -3.164 2 227 20 20 6q21 33 D 1.00 171 0.549 . . -3 1.21 2.11 ? 1 3.166 ? ? ? ? ? ? ? ? PF00071.17 33.243 33.243 68.78 +P01112 33 D E ? P01112 33 D E C G possibly damaging alignment ? deleterious 0.535 0.0951 0.881 0.128 NO NO ? +1.507 -0.970 -2.477 2 227 20 20 6q21 33 D 1.00 171 0.549 . . 27 0.29 2.11 ? 1 3.166 ? ? ? ? 1 2 0 +13 PF00071.17 14.460 14.460 68.78 +P01112 33 D F ? P01112 33 D F ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.414 -0.970 -4.384 2 227 20 20 6q21 33 D 1.00 171 0.549 . . 79 1.33 2.11 ? 1 3.166 ? ? ? ? ? ? ? ? PF00071.17 1.432 ? 68.78 +P01112 33 D G ? P01112 33 D G A G possibly damaging alignment ? deleterious 0.633 0.0891 0.867 0.122 NO NO ? +1.549 -0.970 -2.519 2 227 20 20 6q21 33 D 1.00 171 0.549 . . -51 0.46 2.11 ? 1 3.166 ? ? ? ? 0 1 0 +14 PF00071.17 22.930 22.930 68.78 +P01112 33 D H ? P01112 33 D H G C probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.577 -0.970 -4.547 2 227 20 20 6q21 33 D 1.00 171 0.549 . . 42 0.58 2.11 ? 1 3.166 ? ? ? ? 1 0 1 +15 PF00071.17 1.390 ? 68.78 +P01112 33 D I ? P01112 33 D I ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.124 -0.970 -4.094 2 227 20 20 6q21 33 D 1.00 171 0.549 . . 56 1.23 2.11 ? 1 3.166 ? ? ? ? ? ? ? ? PF00071.17 3.053 ? 68.78 +P01112 33 D K ? P01112 33 D K ? ? probably damaging alignment ? deleterious 0.999 0.00574 0.136 0.0192 NO NO ? +2.579 -0.970 -3.549 2 227 20 20 6q21 33 D 1.00 171 0.549 . . 57 1.59 2.11 ? 1 3.166 ? ? ? ? ? ? ? ? PF00071.17 3.704 ? 68.78 +P01112 33 D L ? P01112 33 D L ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.842 -0.970 -3.812 2 227 20 20 6q21 33 D 1.00 171 0.549 . . 56 1.3 2.11 ? 1 3.166 ? ? ? ? ? ? ? ? PF00071.17 4.370 ? 68.78 +P01112 33 D M ? P01112 33 D M ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.992 -0.970 -4.962 2 227 20 20 6q21 33 D 1.00 171 0.549 . . 52 1.3 2.11 ? 1 3.166 ? ? ? ? ? ? ? ? PF00071.17 1.051 ? 68.78 +P01112 33 D N ? P01112 33 D N G A probably damaging alignment ? deleterious 0.962 0.0478 0.779 0.0767 NO NO ? +1.696 -0.970 -2.666 2 227 20 20 6q21 33 D 1.00 171 0.549 . . 3 0.14 2.11 ? 1 3.166 ? ? ? ? 0 0 1 +15 PF00071.17 13.741 13.741 68.78 +P01112 33 D P ? P01112 33 D P ? ? probably damaging alignment ? deleterious 0.998 0.0112 0.273 0.0274 NO NO ? +2.857 -0.970 -3.827 2 227 20 20 6q21 33 D 1.00 171 0.549 . . 1 0.23 2.11 ? 1 3.166 ? ? ? ? ? ? ? ? PF00071.17 1.274 ? 68.78 +P01112 33 D Q ? P01112 33 D Q ? ? probably damaging alignment ? deleterious 0.999 0.00574 0.136 0.0192 NO NO ? +2.838 -0.970 -3.808 2 227 20 20 6q21 33 D 1.00 171 0.549 . . 33 0.11 2.11 ? 1 3.166 ? ? ? ? ? ? ? ? PF00071.17 3.171 ? 68.78 +P01112 33 D R ? P01112 33 D R ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.005 -0.970 -3.975 2 227 20 20 6q21 33 D 1.00 171 0.549 . . 62 0.45 2.11 ? 1 3.166 ? ? ? ? ? ? ? ? PF00071.17 2.414 ? 68.78 +P01112 33 D S ? P01112 33 D S ? ? probably damaging alignment ? deleterious 0.996 0.0222 0.545 0.0439 NO NO ? +2.298 -0.970 -3.268 2 227 20 20 6q21 33 D 1.00 171 0.549 . . -22 0.48 2.11 ? 1 3.166 ? ? ? ? ? ? ? ? PF00071.17 3.058 ? 68.78 +P01112 33 D T ? P01112 33 D T ? ? probably damaging alignment ? deleterious 0.996 0.0222 0.545 0.0439 NO NO ? +2.559 -0.970 -3.529 2 227 20 20 6q21 33 D 1.00 171 0.549 . . 5 0.53 2.11 ? 1 3.166 ? ? ? ? ? ? ? ? PF00071.17 2.592 ? 68.78 +P01112 33 D V ? P01112 33 D V A T probably damaging alignment ? deleterious 0.998 0.0112 0.273 0.0274 NO NO ? +2.834 -0.970 -3.804 2 227 20 20 6q21 33 D 1.00 171 0.549 . . 29 1.19 2.11 ? 1 3.166 ? ? ? ? 1 1 0 +14 PF00071.17 3.791 ? 68.78 +P01112 33 D W ? P01112 33 D W ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +4.587 -0.970 -5.557 2 227 20 20 6q21 33 D 1.00 171 0.549 . . 116 1.22 2.11 ? 1 3.166 ? ? ? ? ? ? ? ? PF00071.17 0.403 ? 68.78 +P01112 33 D Y ? P01112 33 D Y G T probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.472 -0.970 -4.442 2 227 20 20 6q21 33 D 1.00 171 0.549 . . 82 0.96 2.11 ? 1 3.166 ? ? ? ? 1 0 1 +15 PF00071.17 0.964 ? 68.78 +P01112 34 P A ? P01112 34 P A C G probably damaging alignment ? deleterious 0.999 0.00574 0.136 0.0192 NO NO ? +2.353 -0.776 -3.129 2 227 20 20 6q21 34 D 1.00 171 0.481 T b -24 0.52 1.77 ? 1 3.107 ? ? ? ? 1 0 2 +12 PF00071.17 1.915 ? 42.86 +P01112 34 P C ? P01112 34 P C ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +4.307 -0.776 -5.083 2 227 20 20 6q21 34 D 1.00 171 0.481 T b -4 0.98 1.77 ? 1 3.107 ? ? ? ? ? ? ? ? PF00071.17 0.680 ? 42.86 +P01112 34 P D ? P01112 34 P D ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.795 -0.776 -3.571 2 227 20 20 6q21 34 D 1.00 171 0.481 T b -1 0.23 1.77 ? 1 3.107 ? ? ? ? ? ? ? ? PF00071.17 0.659 ? 42.86 +P01112 34 P E ? P01112 34 P E ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.753 -0.776 -3.529 2 227 20 20 6q21 34 D 1.00 171 0.481 T b 26 0.52 1.77 ? 1 3.107 ? ? ? ? ? ? ? ? PF00071.17 0.868 ? 42.86 +P01112 34 P F ? P01112 34 P F ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.655 -0.776 -4.431 2 227 20 20 6q21 34 D 1.00 171 0.481 T b 78 1.1 1.77 ? 1 3.107 ? ? ? ? ? ? ? ? PF00071.17 2.346 ? 42.86 +P01112 34 P G ? P01112 34 P G ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.671 -0.776 -3.447 2 227 20 20 6q21 34 D 1.00 171 0.481 T b -52 0.23 1.77 ? 1 3.107 ? ? ? ? ? ? ? ? PF00071.17 0.904 ? 42.86 +P01112 34 P H ? P01112 34 P H C A probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.976 -0.776 -4.752 2 227 20 20 6q21 34 D 1.00 171 0.481 T b 41 0.35 1.77 ? 1 3.107 ? ? ? ? 1 1 0 +11 PF00071.17 0.428 ? 42.86 +P01112 34 P I ? P01112 34 P I ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.095 -0.776 -3.871 2 227 20 20 6q21 34 D 1.00 171 0.481 T b 55 1 1.77 ? 1 3.107 ? ? ? ? ? ? ? ? PF00071.17 4.932 ? 42.86 +P01112 34 P K ? P01112 34 P K ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.753 -0.776 -3.529 2 227 20 20 6q21 34 D 1.00 171 0.481 T b 56 1.82 1.77 ? 1 3.107 ? ? ? ? ? ? ? ? PF00071.17 1.067 ? 42.86 +P01112 34 P L ? P01112 34 P L C T probably damaging alignment ? deleterious 0.999 0.00574 0.136 0.0192 NO NO ? +1.840 -0.776 -2.616 2 227 20 20 6q21 34 D 1.00 171 0.481 T b 55 1.07 1.77 ? 1 3.107 ? ? ? ? 0 1 0 +11 PF00071.17 16.094 16.094 42.86 +P01112 34 P M ? P01112 34 P M ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.843 -0.776 -4.619 2 227 20 20 6q21 34 D 1.00 171 0.481 T b 51 1.07 1.77 ? 1 3.107 ? ? ? ? ? ? ? ? PF00071.17 2.136 ? 42.86 +P01112 34 P N ? P01112 34 P N ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.194 -0.776 -3.970 2 227 20 20 6q21 34 D 1.00 171 0.481 T b 2 0.09 1.77 ? 1 3.107 ? ? ? ? ? ? ? ? PF00071.17 0.593 ? 42.86 +P01112 34 P Q ? P01112 34 P Q ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.195 -0.776 -3.971 2 227 20 20 6q21 34 D 1.00 171 0.481 T b 32 0.12 1.77 ? 1 3.107 ? ? ? ? ? ? ? ? PF00071.17 0.701 ? 42.86 +P01112 34 P R ? P01112 34 P R C G probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.209 -0.776 -3.985 2 227 20 20 6q21 34 D 1.00 171 0.481 T b 61 0.68 1.77 ? 1 3.107 ? ? ? ? 1 1 2 +11 PF00071.17 1.048 ? 42.86 +P01112 34 P S ? P01112 34 P S C T probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.682 -0.776 -3.458 2 227 20 20 6q21 34 D 1.00 171 0.481 T b -23 0.25 1.77 ? 1 3.107 ? ? ? ? 0 0 0 +12 PF00071.17 1.052 ? 42.86 +P01112 34 P T ? P01112 34 P T C A probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.697 -0.776 -3.473 2 227 20 20 6q21 34 D 1.00 171 0.481 T b 4 0.3 1.77 ? 1 3.107 ? ? ? ? 1 0 0 +12 PF00071.17 1.440 ? 42.86 +P01112 34 P V ? P01112 34 P V ? ? probably damaging alignment ? deleterious 0.999 0.00574 0.136 0.0192 NO NO ? +2.711 -0.776 -3.487 2 227 20 20 6q21 34 D 1.00 171 0.481 T b 28 0.96 1.77 ? 1 3.107 ? ? ? ? ? ? ? ? PF00071.17 4.107 ? 42.86 +P01112 34 P W ? P01112 34 P W ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +4.767 -0.776 -5.543 2 227 20 20 6q21 34 D 1.00 171 0.481 T b 115 0.99 1.77 ? 1 3.107 ? ? ? ? ? ? ? ? PF00071.17 0.317 ? 42.86 +P01112 34 P Y ? P01112 34 P Y ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.607 -0.776 -4.383 2 227 20 20 6q21 34 D 1.00 171 0.481 T b 81 0.73 1.77 ? 1 3.107 ? ? ? ? ? ? ? ? PF00071.17 0.957 ? 42.86 +P01112 35 T A ? P01112 35 T A A G possibly damaging alignment ? deleterious 0.856 0.067 0.832 0.0984 NO NO ? +2.051 -0.930 -2.981 2 228 20 20 6q21 35 D 1.00 171 0.633 T l -28 0.22 1.53 ? ? ? ? ? ? ? 0 0 2 +9 PF00071.17 4.401 ? 82.01 +P01112 35 T C ? P01112 35 T C ? ? probably damaging alignment ? deleterious 0.999 0.00574 0.136 0.0192 NO NO ? +3.790 -0.930 -4.720 2 228 20 20 6q21 35 D 1.00 171 0.633 T l -8 0.68 1.53 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.238 ? 82.01 +P01112 35 T D ? P01112 35 T D ? ? probably damaging alignment ? deleterious 0.993 0.0301 0.696 0.0553 NO NO ? +2.705 -0.930 -3.635 2 228 20 20 6q21 35 D 1.00 171 0.633 T l -5 0.53 1.53 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.524 ? 82.01 +P01112 35 T E ? P01112 35 T E ? ? probably damaging alignment ? deleterious 0.994 0.0289 0.689 0.0537 NO NO ? +2.661 -0.930 -3.591 2 228 20 20 6q21 35 D 1.00 171 0.633 T l 22 0.82 1.53 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.229 ? 82.01 +P01112 35 T F ? P01112 35 T F ? ? probably damaging alignment ? deleterious 0.999 0.00574 0.136 0.0192 NO NO ? +3.103 -0.930 -4.033 2 228 20 20 6q21 35 D 1.00 171 0.633 T l 74 0.8 1.53 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 3.906 ? 82.01 +P01112 35 T G ? P01112 35 T G ? ? probably damaging alignment ? deleterious 0.998 0.0112 0.273 0.0274 NO NO ? +2.579 -0.930 -3.509 2 228 20 20 6q21 35 D 1.00 171 0.633 T l -56 0.07 1.53 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.405 ? 82.01 +P01112 35 T H ? P01112 35 T H ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.860 -0.930 -4.790 2 228 20 20 6q21 35 D 1.00 171 0.633 T l 37 0.05 1.53 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.256 ? 82.01 +P01112 35 T I ? P01112 35 T I C T possibly damaging alignment ? deleterious 0.808 0.0715 0.841 0.103 NO NO ? +1.538 -0.930 -2.468 2 228 20 20 6q21 35 D 1.00 171 0.633 T l 51 0.7 1.53 ? ? ? ? ? ? ? 0 1 0 +8 PF00071.17 18.677 18.677 82.01 +P01112 35 T K ? P01112 35 T K ? ? probably damaging alignment ? deleterious 0.991 0.0326 0.711 0.0584 NO NO ? +2.659 -0.930 -3.589 2 228 20 20 6q21 35 D 1.00 171 0.633 T l 52 2.12 1.53 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.982 ? 82.01 +P01112 35 T L ? P01112 35 T L ? ? possibly damaging alignment ? deleterious 0.951 0.0522 0.79 0.0823 NO NO ? +2.095 -0.930 -3.025 2 228 20 20 6q21 35 D 1.00 171 0.633 T l 51 0.77 1.53 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 16.177 ? 82.01 +P01112 35 T M ? P01112 35 T M ? ? probably damaging alignment ? deleterious 0.983 0.0387 0.745 0.0657 NO NO ? +2.122 -0.930 -3.052 2 228 20 20 6q21 35 D 1.00 171 0.633 T l 47 0.77 1.53 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 13.283 13.283 82.01 +P01112 35 T N ? P01112 35 T N C A probably damaging alignment ? deleterious 0.974 0.0438 0.763 0.0722 NO NO ? +2.702 -0.930 -3.632 2 228 20 20 6q21 35 D 1.00 171 0.633 T l -2 0.39 1.53 ? ? ? ? ? ? ? 1 1 0 +8 PF00071.17 1.737 ? 82.01 +P01112 35 T P ? P01112 35 T P A C probably damaging alignment ? deleterious 0.998 0.0112 0.273 0.0274 NO NO ? +2.875 -0.930 -3.805 2 228 20 20 6q21 35 D 1.00 171 0.633 T l -4 0.3 1.53 ? ? ? ? ? ? ? 1 0 0 +9 PF00071.17 1.340 ? 82.01 +P01112 35 T Q ? P01112 35 T Q ? ? probably damaging alignment ? deleterious 0.998 0.0112 0.273 0.0274 NO NO ? +3.078 -0.930 -4.008 2 228 20 20 6q21 35 D 1.00 171 0.633 T l 28 0.42 1.53 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.428 ? 82.01 +P01112 35 T R ? P01112 35 T R ? ? probably damaging alignment ? deleterious 0.999 0.00574 0.136 0.0192 NO NO ? +2.910 -0.930 -3.840 2 228 20 20 6q21 35 D 1.00 171 0.633 T l 57 0.98 1.53 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.636 ? 82.01 +P01112 35 T S ? P01112 35 T S A T possibly damaging alignment ? deleterious 0.856 0.067 0.832 0.0984 NO NO ? +2.190 -0.930 -3.120 2 228 20 20 6q21 35 D 1.00 171 0.633 T l -27 0.05 1.53 ? ? ? ? ? ? ? 1 0 0 +9 PF00071.17 2.809 ? 82.01 +P01112 35 T V ? P01112 35 T V ? ? probably damaging alignment ? deleterious 0.976 0.043 0.76 0.0712 NO NO ? +2.093 -0.930 -3.023 2 228 20 20 6q21 35 D 1.00 171 0.633 T l 24 0.66 1.53 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 12.125 ? 82.01 +P01112 35 T W ? P01112 35 T W ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +4.255 -0.930 -5.185 2 228 20 20 6q21 35 D 1.00 171 0.633 T l 111 0.69 1.53 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 0.652 ? 82.01 +P01112 35 T Y ? P01112 35 T Y ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.262 -0.930 -4.192 2 228 20 20 6q21 35 D 1.00 171 0.633 T l 77 0.43 1.53 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.875 ? 82.01 +P01112 36 I A ? P01112 36 I A ? ? probably damaging alignment ? deleterious 0.975 0.0436 0.762 0.072 NO NO ? +1.936 -1.185 -3.121 2 230 20 20 6q21 36 D 1.00 171 0.639 . B -79 0.48 1.67 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 5.218 ? 71.43 +P01112 36 I C ? P01112 36 I C ? ? possibly damaging alignment ? deleterious 0.755 0.0772 0.852 0.109 NO NO ? +1.905 -1.185 -3.090 2 230 20 20 6q21 36 D 1.00 171 0.639 . B -59 0.02 1.67 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 20.968 20.968 71.43 +P01112 36 I D ? P01112 36 I D ? ? probably damaging alignment ? deleterious 0.997 0.0167 0.409 0.0357 NO NO ? +2.801 -1.185 -3.986 2 230 20 20 6q21 36 D 1.00 171 0.639 . B -56 1.23 1.67 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.661 ? 71.43 +P01112 36 I E ? P01112 36 I E ? ? probably damaging alignment ? deleterious 0.995 0.0277 0.681 0.0521 NO NO ? +2.746 -1.185 -3.931 2 230 20 20 6q21 36 D 1.00 171 0.639 . B -29 1.52 1.67 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.876 ? 71.43 +P01112 36 I F ? P01112 36 I F ? ? probably damaging alignment ? deleterious 0.968 0.0455 0.772 0.074 NO NO ? +2.632 -1.185 -3.817 2 230 20 20 6q21 36 D 1.00 171 0.639 . B 23 0.1 1.67 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 3.563 ? 71.43 +P01112 36 I G ? P01112 36 I G ? ? probably damaging alignment ? deleterious 0.987 0.036 0.731 0.0626 NO NO ? +2.632 -1.185 -3.817 2 230 20 20 6q21 36 D 1.00 171 0.639 . B -107 0.77 1.67 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 3.068 ? 71.43 +P01112 36 I H ? P01112 36 I H ? ? probably damaging alignment ? deleterious 0.999 0.00574 0.136 0.0192 NO NO ? +3.801 -1.185 -4.986 2 230 20 20 6q21 36 D 1.00 171 0.639 . B -14 0.65 1.67 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.044 ? 71.43 +P01112 36 I K ? P01112 36 I K T A possibly damaging alignment ? deleterious 0.629 0.0892 0.868 0.122 NO NO ? +2.722 -1.185 -3.907 2 230 20 20 6q21 36 D 1.00 171 0.639 . B 1 2.82 1.67 ? ? ? ? ? ? ? 1 1 0 +5 PF00071.17 3.294 ? 71.43 +P01112 36 I L ? P01112 36 I L A T benign alignment ? neutral 0.003 0.556 0.981 0.39 NO NO ? +0.937 -1.185 -2.122 2 230 20 20 6q21 36 D 1.00 171 0.639 . B 0 0.07 1.67 ? ? ? ? ? ? ? 1 0 0 +6 PF00071.17 24.438 24.438 71.43 +P01112 36 I M ? P01112 36 I M A G probably damaging alignment ? deleterious 0.963 0.0475 0.778 0.0764 NO NO ? +2.997 -1.185 -4.182 2 230 20 20 6q21 36 D 1.00 171 0.639 . B -4 0.07 1.67 ? ? ? ? ? ? ? 0 2 0 +4 PF00071.17 3.243 ? 71.43 +P01112 36 I N ? P01112 36 I N ? ? probably damaging alignment ? deleterious 0.997 0.0167 0.409 0.0357 NO NO ? +2.941 -1.185 -4.126 2 230 20 20 6q21 36 D 1.00 171 0.639 . B -53 1.09 1.67 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 3.138 ? 71.43 +P01112 36 I P ? P01112 36 I P ? ? probably damaging alignment ? deleterious 0.998 0.0112 0.273 0.0274 NO NO ? +2.947 -1.185 -4.132 2 230 20 20 6q21 36 D 1.00 171 0.639 . B -55 1 1.67 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.896 ? 71.43 +P01112 36 I Q ? P01112 36 I Q ? ? probably damaging alignment ? deleterious 0.996 0.0222 0.545 0.0439 NO NO ? +3.164 -1.185 -4.349 2 230 20 20 6q21 36 D 1.00 171 0.639 . B -23 1.12 1.67 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.936 ? 71.43 +P01112 36 I R ? P01112 36 I R T G probably damaging alignment ? deleterious 0.994 0.0289 0.689 0.0537 NO NO ? +2.991 -1.185 -4.176 2 230 20 20 6q21 36 D 1.00 171 0.639 . B 6 1.68 1.67 ? ? ? ? ? ? ? 1 1 0 +5 PF00071.17 2.499 ? 71.43 +P01112 36 I S ? P01112 36 I S ? ? probably damaging alignment ? deleterious 0.975 0.0436 0.762 0.072 NO NO ? +2.411 -1.185 -3.596 2 230 20 20 6q21 36 D 1.00 171 0.639 . B -78 0.75 1.67 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 6.597 ? 71.43 +P01112 36 I T ? P01112 36 I T T C benign alignment ? neutral 0.26 0.118 0.91 0.149 NO NO ? +1.266 -1.185 -2.451 2 230 20 20 6q21 36 D 1.00 171 0.639 . B -51 0.7 1.67 ? ? ? ? ? ? ? 0 1 0 +5 PF00071.17 17.565 17.565 71.43 +P01112 36 I V ? P01112 36 I V A G benign alignment ? neutral 0.116 0.142 0.927 0.172 NO NO ? +1.100 -1.185 -2.285 2 230 20 20 6q21 36 D 1.00 171 0.639 . B -27 0.04 1.67 ? ? ? ? ? ? ? 0 0 0 +6 PF00071.17 11.823 11.823 71.43 +P01112 36 I W ? P01112 36 I W ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +4.171 -1.185 -5.356 2 230 20 20 6q21 36 D 1.00 171 0.639 . B 60 0.01 1.67 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 0.482 ? 71.43 +P01112 36 I Y ? P01112 36 I Y ? ? probably damaging alignment ? deleterious 0.988 0.0353 0.727 0.0617 NO NO ? +2.902 -1.185 -4.087 2 230 20 20 6q21 36 D 1.00 171 0.639 . B 26 0.27 1.67 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.454 ? 71.43 +P01112 37 E A ? P01112 37 E A A C probably damaging alignment ? deleterious 0.976 0.043 0.76 0.0712 NO NO ? +2.076 -1.112 -3.188 2 233 20 20 6q21 37 D 1.00 171 0.374 . B -50 1.04 1.26 ? ? ? ? ? ? ? 1 1 2 +2 PF00071.17 4.636 ? 82.54 +P01112 37 E C ? P01112 37 E C ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +4.216 -1.112 -5.328 2 233 20 20 6q21 37 D 1.00 171 0.374 . B -30 1.5 1.26 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 0.745 ? 82.54 +P01112 37 E D ? P01112 37 E D G C possibly damaging alignment ? deleterious 0.913 0.0604 0.813 0.0915 NO NO ? +1.983 -1.112 -3.095 2 233 20 20 6q21 37 D 1.00 171 0.374 . B -27 0.29 1.26 ? ? ? ? ? ? ? 1 2 2 +1 PF00071.17 3.971 ? 82.54 +P01112 37 E F ? P01112 37 E F ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.290 -1.112 -4.402 2 233 20 20 6q21 37 D 1.00 171 0.374 . B 52 1.62 1.26 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.307 ? 82.54 +P01112 37 E G ? P01112 37 E G A G probably damaging alignment ? deleterious 0.996 0.0222 0.545 0.0439 NO NO ? +2.356 -1.112 -3.468 2 233 20 20 6q21 37 D 1.00 171 0.374 . B -78 0.75 1.26 ? ? ? ? ? ? ? 0 1 0 +2 PF00071.17 3.297 ? 82.54 +P01112 37 E H ? P01112 37 E H ? ? probably damaging alignment ? deleterious 0.999 0.00574 0.136 0.0192 NO NO ? +3.252 -1.112 -4.364 2 233 20 20 6q21 37 D 1.00 171 0.374 . B 15 0.87 1.26 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.527 ? 82.54 +P01112 37 E I ? P01112 37 E I ? ? probably damaging alignment ? deleterious 0.999 0.00574 0.136 0.0192 NO NO ? +3.008 -1.112 -4.120 2 233 20 20 6q21 37 D 1.00 171 0.374 . B 29 1.52 1.26 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.147 ? 82.54 +P01112 37 E K ? P01112 37 E K G A benign alignment ? neutral 0.415 0.103 0.893 0.135 NO NO ? +1.197 -1.112 -2.309 2 233 20 20 6q21 37 D 1.00 171 0.374 . B 30 1.3 1.26 ? ? ? ? ? ? ? 0 0 0 +3 PF00071.17 19.791 19.791 82.54 +P01112 37 E L ? P01112 37 E L ? ? probably damaging alignment ? deleterious 0.989 0.0346 0.723 0.0608 NO NO ? +2.487 -1.112 -3.599 2 233 20 20 6q21 37 D 1.00 171 0.374 . B 29 1.59 1.26 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 3.897 ? 82.54 +P01112 37 E M ? P01112 37 E M ? ? probably damaging alignment ? deleterious 0.992 0.0314 0.704 0.0568 NO NO ? +3.554 -1.112 -4.666 2 233 20 20 6q21 37 D 1.00 171 0.374 . B 25 1.59 1.26 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.783 ? 82.54 +P01112 37 E N ? P01112 37 E N ? ? probably damaging alignment ? deleterious 0.977 0.0424 0.758 0.0704 NO NO ? +2.446 -1.112 -3.558 2 233 20 20 6q21 37 D 1.00 171 0.374 . B -24 0.43 1.26 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 3.687 ? 82.54 +P01112 37 E P ? P01112 37 E P ? ? probably damaging alignment ? deleterious 0.966 0.0465 0.775 0.0751 NO NO ? +2.668 -1.112 -3.780 2 233 20 20 6q21 37 D 1.00 171 0.374 . B -26 0.52 1.26 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.040 ? 82.54 +P01112 37 E Q ? P01112 37 E Q G C possibly damaging alignment ? deleterious 0.685 0.0836 0.861 0.116 NO NO ? +1.020 -1.112 -2.132 2 233 20 20 6q21 37 D 1.00 171 0.374 . B 6 0.4 1.26 ? ? ? ? ? ? ? 1 0 0 +3 PF00071.17 17.658 17.658 82.54 +P01112 37 E R ? P01112 37 E R ? ? possibly damaging alignment ? deleterious 0.695 0.0828 0.86 0.115 NO NO ? +1.603 -1.112 -2.715 2 233 20 20 6q21 37 D 1.00 171 0.374 . B 35 0.16 1.26 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 20.206 20.206 82.54 +P01112 37 E S ? P01112 37 E S ? ? probably damaging alignment ? deleterious 0.982 0.0393 0.748 0.0664 NO NO ? +2.174 -1.112 -3.286 2 233 20 20 6q21 37 D 1.00 171 0.374 . B -49 0.77 1.26 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 4.561 ? 82.54 +P01112 37 E T ? P01112 37 E T ? ? probably damaging alignment ? deleterious 0.993 0.0301 0.696 0.0553 NO NO ? +2.419 -1.112 -3.531 2 233 20 20 6q21 37 D 1.00 171 0.374 . B -22 0.82 1.26 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 3.324 ? 82.54 +P01112 37 E V ? P01112 37 E V A T probably damaging alignment ? deleterious 0.98 0.0405 0.753 0.0679 NO NO ? +2.542 -1.112 -3.654 2 233 20 20 6q21 37 D 1.00 171 0.374 . B 2 1.48 1.26 ? ? ? ? ? ? ? 1 1 0 +2 PF00071.17 2.809 ? 82.54 +P01112 37 E W ? P01112 37 E W ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +4.272 -1.112 -5.384 2 233 20 20 6q21 37 D 1.00 171 0.374 . B 89 1.51 1.26 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 0.548 ? 82.54 +P01112 37 E Y ? P01112 37 E Y ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.112 -1.112 -4.224 2 233 20 20 6q21 37 D 1.00 171 0.374 . B 55 1.25 1.26 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.628 ? 82.54 +P01112 38 D A ? P01112 38 D A A C probably damaging alignment ? deleterious 0.99 0.0338 0.719 0.06 NO NO ? +2.259 -1.058 -3.317 2 235 20 20 6q21 38 D 1.00 171 0.421 . B -23 0.75 1.40 ? ? ? ? ? ? ? 1 1 0 -2 PF00071.17 5.520 ? 70.37 +P01112 38 D C ? P01112 38 D C ? ? probably damaging alignment ? deleterious 0.999 0.00574 0.136 0.0192 NO NO ? +4.130 -1.058 -5.188 2 235 20 20 6q21 38 D 1.00 171 0.421 . B -3 1.21 1.40 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 0.730 ? 70.37 +P01112 38 D E ? P01112 38 D E T G probably damaging alignment ? deleterious 0.979 0.0411 0.755 0.0687 NO NO ? +1.983 -1.058 -3.041 2 235 20 20 6q21 38 D 1.00 171 0.421 . B 27 0.29 1.40 ? ? ? ? ? ? ? 1 2 0 -3 PF00071.17 2.514 ? 70.37 +P01112 38 D F ? P01112 38 D F ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.335 -1.058 -4.393 2 235 20 20 6q21 38 D 1.00 171 0.421 . B 79 1.33 1.40 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.137 ? 70.37 +P01112 38 D G ? P01112 38 D G A G benign alignment ? neutral 0.416 0.103 0.893 0.135 NO NO ? +1.181 -1.058 -2.239 2 235 20 20 6q21 38 D 1.00 171 0.421 . B -51 0.46 1.40 ? ? ? ? ? ? ? 0 1 0 -2 PF00071.17 35.879 35.879 70.37 +P01112 38 D H ? P01112 38 D H G C probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.413 -1.058 -4.471 2 235 20 20 6q21 38 D 1.00 171 0.421 . B 42 0.58 1.40 ? ? ? ? ? ? ? 1 0 0 -1 PF00071.17 1.627 ? 70.37 +P01112 38 D I ? P01112 38 D I ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.078 -1.058 -4.136 2 235 20 20 6q21 38 D 1.00 171 0.421 . B 56 1.23 1.40 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.314 ? 70.37 +P01112 38 D K ? P01112 38 D K ? ? probably damaging alignment ? deleterious 0.998 0.0112 0.273 0.0274 NO NO ? +2.409 -1.058 -3.467 2 235 20 20 6q21 38 D 1.00 171 0.421 . B 57 1.59 1.40 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 5.432 ? 70.37 +P01112 38 D L ? P01112 38 D L ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.767 -1.058 -3.825 2 235 20 20 6q21 38 D 1.00 171 0.421 . B 56 1.3 1.40 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.108 ? 70.37 +P01112 38 D M ? P01112 38 D M ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.889 -1.058 -4.947 2 235 20 20 6q21 38 D 1.00 171 0.421 . B 52 1.3 1.40 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 0.700 ? 70.37 +P01112 38 D N ? P01112 38 D N G A possibly damaging alignment ? deleterious 0.653 0.0873 0.866 0.12 NO NO ? +1.145 -1.058 -2.203 2 235 20 20 6q21 38 D 1.00 171 0.421 . B 3 0.14 1.40 ? ? ? ? ? ? ? 0 0 0 -1 PF00071.17 16.087 16.087 70.37 +P01112 38 D P ? P01112 38 D P ? ? probably damaging alignment ? deleterious 0.998 0.0112 0.273 0.0274 NO NO ? +2.774 -1.058 -3.832 2 235 20 20 6q21 38 D 1.00 171 0.421 . B 1 0.23 1.40 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.295 ? 70.37 +P01112 38 D Q ? P01112 38 D Q ? ? probably damaging alignment ? deleterious 0.999 0.00574 0.136 0.0192 NO NO ? +2.741 -1.058 -3.799 2 235 20 20 6q21 38 D 1.00 171 0.421 . B 33 0.11 1.40 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.166 ? 70.37 +P01112 38 D R ? P01112 38 D R ? ? probably damaging alignment ? deleterious 0.98 0.0405 0.753 0.0679 NO NO ? +1.812 -1.058 -2.870 2 235 20 20 6q21 38 D 1.00 171 0.421 . B 62 0.45 1.40 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 15.473 15.473 70.37 +P01112 38 D S ? P01112 38 D S ? ? probably damaging alignment ? deleterious 0.996 0.0222 0.545 0.0439 NO NO ? +2.179 -1.058 -3.237 2 235 20 20 6q21 38 D 1.00 171 0.421 . B -22 0.48 1.40 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 3.639 ? 70.37 +P01112 38 D T ? P01112 38 D T ? ? probably damaging alignment ? deleterious 0.996 0.0222 0.545 0.0439 NO NO ? +2.448 -1.058 -3.506 2 235 20 20 6q21 38 D 1.00 171 0.421 . B 5 0.53 1.40 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.544 ? 70.37 +P01112 38 D V ? P01112 38 D V A T probably damaging alignment ? deleterious 0.999 0.00574 0.136 0.0192 NO NO ? +2.796 -1.058 -3.854 2 235 20 20 6q21 38 D 1.00 171 0.421 . B 29 1.19 1.40 ? ? ? ? ? ? ? 1 1 0 -2 PF00071.17 1.729 ? 70.37 +P01112 38 D W ? P01112 38 D W ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +4.504 -1.058 -5.562 2 235 20 20 6q21 38 D 1.00 171 0.421 . B 116 1.22 1.40 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 0.387 ? 70.37 +P01112 38 D Y ? P01112 38 D Y G T probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.370 -1.058 -4.428 2 235 20 20 6q21 38 D 1.00 171 0.421 . B 82 0.96 1.40 ? ? ? ? ? ? ? 1 0 0 -1 PF00071.17 0.807 ? 70.37 +P01112 39 S A ? P01112 39 S A T G benign alignment ? neutral 0.298 0.114 0.906 0.145 NO NO ? +1.702 -1.219 -2.921 2 233 20 20 6q21 39 D 1.00 171 0.536 E B -1 0.27 0.69 ? ? ? ? ? ? ? 1 0 0 -4 PF00071.17 5.520 ? 70.37 +P01112 39 S C ? P01112 39 S C C G probably damaging alignment ? deleterious 0.999 0.00574 0.136 0.0192 NO NO ? +3.603 -1.219 -4.822 2 233 20 20 6q21 39 D 1.00 171 0.536 E B 19 0.73 0.69 ? ? ? ? ? ? ? 1 1 0 -5 PF00071.17 0.832 ? 70.37 +P01112 39 S D ? P01112 39 S D ? ? probably damaging alignment ? deleterious 0.991 0.0326 0.711 0.0584 NO NO ? +2.349 -1.219 -3.568 2 233 20 20 6q21 39 D 1.00 171 0.536 E B 22 0.48 0.69 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.394 ? 70.37 +P01112 39 S E ? P01112 39 S E ? ? probably damaging alignment ? deleterious 0.993 0.0301 0.696 0.0553 NO NO ? +2.326 -1.219 -3.545 2 233 20 20 6q21 39 D 1.00 171 0.536 E B 49 0.77 0.69 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.839 ? 70.37 +P01112 39 S F ? P01112 39 S F C T benign alignment ? neutral 0.416 0.103 0.893 0.135 NO NO ? +1.231 -1.219 -2.450 2 233 20 20 6q21 39 D 1.00 171 0.536 E B 101 0.85 0.69 ? ? ? ? ? ? ? 0 1 0 -5 PF00071.17 19.579 19.579 70.37 +P01112 39 S G ? P01112 39 S G ? ? benign alignment ? neutral 0.319 0.112 0.903 0.143 NO NO ? +1.323 -1.219 -2.542 2 233 20 20 6q21 39 D 1.00 171 0.536 E B -29 0.02 0.69 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 35.879 35.879 70.37 +P01112 39 S H ? P01112 39 S H ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.449 -1.219 -4.668 2 233 20 20 6q21 39 D 1.00 171 0.536 E B 64 0.1 0.69 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 0.909 ? 70.37 +P01112 39 S I ? P01112 39 S I ? ? probably damaging alignment ? deleterious 0.966 0.0465 0.775 0.0751 NO NO ? +1.641 -1.219 -2.860 2 233 20 20 6q21 39 D 1.00 171 0.536 E B 78 0.75 0.69 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 11.062 11.062 70.37 +P01112 39 S K ? P01112 39 S K ? ? probably damaging alignment ? deleterious 0.998 0.0112 0.273 0.0274 NO NO ? +2.331 -1.219 -3.550 2 233 20 20 6q21 39 D 1.00 171 0.536 E B 79 2.07 0.69 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.410 ? 70.37 +P01112 39 S L ? P01112 39 S L ? ? possibly damaging alignment ? deleterious 0.907 0.0615 0.815 0.0927 NO NO ? +1.411 -1.219 -2.630 2 233 20 20 6q21 39 D 1.00 171 0.536 E B 78 0.82 0.69 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 16.094 16.094 70.37 +P01112 39 S M ? P01112 39 S M ? ? probably damaging alignment ? deleterious 0.999 0.00574 0.136 0.0192 NO NO ? +3.274 -1.219 -4.493 2 233 20 20 6q21 39 D 1.00 171 0.536 E B 74 0.82 0.69 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.136 ? 70.37 +P01112 39 S N ? P01112 39 S N ? ? possibly damaging alignment ? deleterious 0.862 0.0664 0.83 0.0979 NO NO ? +2.356 -1.219 -3.575 2 233 20 20 6q21 39 D 1.00 171 0.536 E B 25 0.34 0.69 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.714 ? 70.37 +P01112 39 S P ? P01112 39 S P T C probably damaging alignment ? deleterious 0.996 0.0222 0.545 0.0439 NO NO ? +2.712 -1.219 -3.931 2 233 20 20 6q21 39 D 1.00 171 0.536 E B 23 0.25 0.69 ? ? ? ? ? ? ? 0 0 0 -4 PF00071.17 1.295 ? 70.37 +P01112 39 S Q ? P01112 39 S Q ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.774 -1.219 -3.993 2 233 20 20 6q21 39 D 1.00 171 0.536 E B 55 0.37 0.69 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.299 ? 70.37 +P01112 39 S R ? P01112 39 S R ? ? probably damaging alignment ? deleterious 0.998 0.0112 0.273 0.0274 NO NO ? +2.731 -1.219 -3.950 2 233 20 20 6q21 39 D 1.00 171 0.536 E B 84 0.93 0.69 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.634 ? 70.37 +P01112 39 S T ? P01112 39 S T T A benign alignment ? neutral 0.402 0.105 0.895 0.137 NO NO ? +1.409 -1.219 -2.628 2 233 20 20 6q21 39 D 1.00 171 0.536 E B 27 0.05 0.69 ? ? ? ? ? ? ? 1 0 0 -4 PF00071.17 11.190 11.190 70.37 +P01112 39 S V ? P01112 39 S V ? ? probably damaging alignment ? deleterious 0.974 0.0438 0.763 0.0722 NO NO ? +2.187 -1.219 -3.406 2 233 20 20 6q21 39 D 1.00 171 0.536 E B 51 0.71 0.69 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 7.182 ? 70.37 +P01112 39 S W ? P01112 39 S W ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.995 -1.219 -5.214 2 233 20 20 6q21 39 D 1.00 171 0.536 E B 138 0.74 0.69 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 0.910 ? 70.37 +P01112 39 S Y ? P01112 39 S Y C A probably damaging alignment ? deleterious 0.996 0.0222 0.545 0.0439 NO NO ? +2.791 -1.219 -4.010 2 233 20 20 6q21 39 D 1.00 171 0.536 E B 104 0.48 0.69 ? ? ? ? ? ? ? 1 1 0 -5 PF00071.17 4.541 ? 70.37 +P01112 40 Y A ? P01112 40 Y A ? ? probably damaging alignment ? deleterious 0.999 0.00574 0.136 0.0192 NO NO ? +2.234 -1.129 -3.363 2 235 20 20 6q21 40 D 1.00 171 0.204 E B -105 0.21 0.20 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 3.396 ? 77.78 +P01112 40 Y C ? P01112 40 Y C A G probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.871 -1.129 -5.000 2 235 20 20 6q21 40 D 1.00 171 0.204 E B -85 0.25 0.20 ? ? ? ? ? ? ? 0 1 0 -8 PF00071.17 1.091 ? 77.78 +P01112 40 Y D ? P01112 40 Y D T G probably damaging alignment ? deleterious 0.996 0.0222 0.545 0.0439 NO NO ? +2.685 -1.129 -3.814 2 235 20 20 6q21 40 D 1.00 171 0.204 E B -82 0.96 0.20 ? ? ? ? ? ? ? 1 0 2 -7 PF00071.17 6.481 ? 77.78 +P01112 40 Y E ? P01112 40 Y E ? ? probably damaging alignment ? deleterious 0.999 0.00574 0.136 0.0192 NO NO ? +2.501 -1.129 -3.630 2 235 20 20 6q21 40 D 1.00 171 0.204 E B -55 1.25 0.20 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 3.850 ? 77.78 +P01112 40 Y F ? P01112 40 Y F A T probably damaging alignment ? deleterious 0.985 0.0375 0.74 0.0643 NO NO ? +2.186 -1.129 -3.315 2 235 20 20 6q21 40 D 1.00 171 0.204 E B -3 0.37 0.20 ? ? ? ? ? ? ? 1 1 0 -8 PF00071.17 3.766 ? 77.78 +P01112 40 Y G ? P01112 40 Y G ? ? probably damaging alignment ? deleterious 0.997 0.0167 0.409 0.0357 NO NO ? +2.422 -1.129 -3.551 2 235 20 20 6q21 40 D 1.00 171 0.204 E B -133 0.5 0.20 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 4.981 ? 77.78 +P01112 40 Y H ? P01112 40 Y H T C possibly damaging alignment ? deleterious 0.65 0.0878 0.866 0.121 NO NO ? +1.771 -1.129 -2.900 2 235 20 20 6q21 40 D 1.00 171 0.204 E B -40 0.38 0.20 ? ? ? ? ? ? ? 0 0 0 -7 PF00071.17 24.913 24.913 77.78 +P01112 40 Y I ? P01112 40 Y I ? ? possibly damaging alignment ? deleterious 0.933 0.0573 0.804 0.0882 NO NO ? +2.557 -1.129 -3.686 2 235 20 20 6q21 40 D 1.00 171 0.204 E B -26 0.27 0.20 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 7.916 ? 77.78 +P01112 40 Y K ? P01112 40 Y K ? ? probably damaging alignment ? deleterious 0.977 0.0424 0.758 0.0704 NO NO ? +2.464 -1.129 -3.593 2 235 20 20 6q21 40 D 1.00 171 0.204 E B -25 2.55 0.20 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 4.921 ? 77.78 +P01112 40 Y L ? P01112 40 Y L ? ? benign alignment ? neutral 0.241 0.12 0.912 0.151 NO NO ? +1.469 -1.129 -2.598 2 235 20 20 6q21 40 D 1.00 171 0.204 E B -26 0.34 0.20 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 25.829 25.829 77.78 +P01112 40 Y M ? P01112 40 Y M ? ? probably damaging alignment ? deleterious 0.999 0.00574 0.136 0.0192 NO NO ? +3.415 -1.129 -4.544 2 235 20 20 6q21 40 D 1.00 171 0.204 E B -30 0.34 0.20 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 3.428 ? 77.78 +P01112 40 Y N ? P01112 40 Y N T A possibly damaging alignment ? deleterious 0.861 0.0665 0.83 0.0979 NO NO ? +1.404 -1.129 -2.533 2 235 20 20 6q21 40 D 1.00 171 0.204 E B -79 0.82 0.20 ? ? ? ? ? ? ? 1 0 0 -7 PF00071.17 24.634 24.634 77.78 +P01112 40 Y P ? P01112 40 Y P ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.007 -1.129 -4.136 2 235 20 20 6q21 40 D 1.00 171 0.204 E B -81 0.73 0.20 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.499 ? 77.78 +P01112 40 Y Q ? P01112 40 Y Q ? ? probably damaging alignment ? deleterious 0.999 0.00574 0.136 0.0192 NO NO ? +2.793 -1.129 -3.922 2 235 20 20 6q21 40 D 1.00 171 0.204 E B -49 0.85 0.20 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.816 ? 77.78 +P01112 40 Y R ? P01112 40 Y R ? ? possibly damaging alignment ? deleterious 0.936 0.0568 0.802 0.0876 NO NO ? +1.733 -1.129 -2.862 2 235 20 20 6q21 40 D 1.00 171 0.204 E B -20 1.41 0.20 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 14.016 14.016 77.78 +P01112 40 Y S ? P01112 40 Y S A C probably damaging alignment ? deleterious 0.996 0.0222 0.545 0.0439 NO NO ? +2.435 -1.129 -3.564 2 235 20 20 6q21 40 D 1.00 171 0.204 E B -104 0.48 0.20 ? ? ? ? ? ? ? 1 1 0 -8 PF00071.17 5.482 ? 77.78 +P01112 40 Y T ? P01112 40 Y T ? ? probably damaging alignment ? deleterious 0.999 0.00574 0.136 0.0192 NO NO ? +2.513 -1.129 -3.642 2 235 20 20 6q21 40 D 1.00 171 0.204 E B -77 0.43 0.20 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 3.895 ? 77.78 +P01112 40 Y V ? P01112 40 Y V ? ? probably damaging alignment ? deleterious 0.997 0.0167 0.409 0.0357 NO NO ? +2.334 -1.129 -3.463 2 235 20 20 6q21 40 D 1.00 171 0.204 E B -53 0.23 0.20 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 6.592 ? 77.78 +P01112 40 Y W ? P01112 40 Y W ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.446 -1.129 -4.575 2 235 20 20 6q21 40 D 1.00 171 0.204 E B 34 0.26 0.20 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 0.509 ? 77.78 +P01112 41 R A ? P01112 41 R A ? ? possibly damaging alignment ? deleterious 0.874 0.0654 0.827 0.0968 NO NO ? +1.731 -1.428 -3.159 2 234 20 20 6q21 41 D 1.00 171 0.321 E B -85 1.2 0.95 ? ? ? 2 3.327 ? ? ? ? ? ? PF00071.17 5.025 ? 77.78 +P01112 41 R C ? P01112 41 R C ? ? possibly damaging alignment ? deleterious 0.661 0.0864 0.864 0.119 NO NO ? +1.838 -1.428 -3.266 2 234 20 20 6q21 41 D 1.00 171 0.321 E B -65 1.66 0.95 ? ? ? 2 3.327 ? ? ? ? ? ? PF00071.17 21.991 21.991 77.78 +P01112 41 R D ? P01112 41 R D ? ? probably damaging alignment ? deleterious 0.98 0.0405 0.753 0.0679 NO NO ? +2.298 -1.428 -3.726 2 234 20 20 6q21 41 D 1.00 171 0.321 E B -62 0.45 0.95 ? ? ? 2 3.327 ? ? ? ? ? ? PF00071.17 3.742 ? 77.78 +P01112 41 R E ? P01112 41 R E ? ? possibly damaging alignment ? deleterious 0.879 0.0648 0.825 0.0962 NO NO ? +2.010 -1.428 -3.438 2 234 20 20 6q21 41 D 1.00 171 0.321 E B -35 0.16 0.95 ? ? ? 2 3.327 ? ? ? ? ? ? PF00071.17 8.033 ? 77.78 +P01112 41 R F ? P01112 41 R F ? ? probably damaging alignment ? deleterious 0.986 0.0368 0.736 0.0634 NO NO ? +2.863 -1.428 -4.291 2 234 20 20 6q21 41 D 1.00 171 0.321 E B 17 1.78 0.95 ? ? ? 2 3.327 ? ? ? ? ? ? PF00071.17 2.800 ? 77.78 +P01112 41 R G ? P01112 41 R G C G probably damaging alignment ? deleterious 0.989 0.0346 0.723 0.0608 NO NO ? +2.067 -1.428 -3.495 2 234 20 20 6q21 41 D 1.00 171 0.321 E B -113 0.91 0.95 ? ? ? 2 3.327 ? ? 1 0 3 -10 PF00071.17 3.106 ? 77.78 +P01112 41 R H ? P01112 41 R H ? ? possibly damaging alignment ? neutral 0.497 0.0968 0.884 0.129 NO NO ? +1.422 -1.428 -2.850 2 234 20 20 6q21 41 D 1.00 171 0.321 E B -20 1.03 0.95 ? ? ? 2 3.327 ? ? ? ? ? ? PF00071.17 17.608 17.608 77.78 +P01112 41 R I ? P01112 41 R I ? ? possibly damaging alignment ? neutral 0.497 0.0968 0.884 0.129 NO NO ? +1.598 -1.428 -3.026 2 234 20 20 6q21 41 D 1.00 171 0.321 E B -6 1.68 0.95 ? ? ? 2 3.327 ? ? ? ? ? ? PF00071.17 16.953 16.953 77.78 +P01112 41 R K ? P01112 41 R K ? ? benign alignment ? neutral 0.452 0.0998 0.889 0.132 NO NO ? +1.813 -1.428 -3.241 2 234 20 20 6q21 41 D 1.00 171 0.321 E B -5 1.14 0.95 ? ? ? 2 3.327 ? ? ? ? ? ? PF00071.17 7.031 ? 77.78 +P01112 41 R L ? P01112 41 R L G T possibly damaging alignment ? deleterious 0.951 0.0522 0.79 0.0823 NO NO ? +1.988 -1.428 -3.416 2 234 20 20 6q21 41 D 1.00 171 0.321 E B -6 1.75 0.95 ? ? ? 2 3.327 ? ? 1 1 1 -11 PF00071.17 10.463 ? 77.78 +P01112 41 R M ? P01112 41 R M ? ? probably damaging alignment ? deleterious 0.994 0.0289 0.689 0.0537 NO NO ? +3.187 -1.428 -4.615 2 234 20 20 6q21 41 D 1.00 171 0.321 E B -10 1.75 0.95 ? ? ? 2 3.327 ? ? ? ? ? ? PF00071.17 2.306 ? 77.78 +P01112 41 R N ? P01112 41 R N ? ? probably damaging alignment ? deleterious 0.98 0.0405 0.753 0.0679 NO NO ? +2.214 -1.428 -3.642 2 234 20 20 6q21 41 D 1.00 171 0.321 E B -59 0.59 0.95 ? ? ? 2 3.327 ? ? ? ? ? ? PF00071.17 3.474 ? 77.78 +P01112 41 R P ? P01112 41 R P G C possibly damaging alignment ? deleterious 0.516 0.0961 0.883 0.129 NO NO ? +1.505 -1.428 -2.933 2 234 20 20 6q21 41 D 1.00 171 0.321 E B -61 0.68 0.95 ? ? ? 2 3.327 ? ? 1 1 3 -11 PF00071.17 20.156 20.156 77.78 +P01112 41 R Q ? P01112 41 R Q G A possibly damaging alignment ? deleterious 0.882 0.0644 0.824 0.0959 NO NO ? +1.521 -1.428 -2.949 2 234 20 20 6q21 41 D 1.00 171 0.321 E B -29 0.56 0.95 ? ? ? 2 3.327 ? ? 0 1 1 -11 PF00071.17 16.639 16.639 77.78 +P01112 41 R S ? P01112 41 R S ? ? possibly damaging alignment ? deleterious 0.741 0.0787 0.853 0.111 NO NO ? +1.129 -1.428 -2.557 2 234 20 20 6q21 41 D 1.00 171 0.321 E B -84 0.93 0.95 ? ? ? 2 3.327 ? ? ? ? ? ? PF00071.17 9.891 9.891 77.78 +P01112 41 R T ? P01112 41 R T ? ? possibly damaging alignment ? neutral 0.495 0.097 0.884 0.129 NO NO ? +1.126 -1.428 -2.554 2 234 20 20 6q21 41 D 1.00 171 0.321 E B -57 0.98 0.95 ? ? ? 2 3.327 ? ? ? ? ? ? PF00071.17 16.915 16.915 77.78 +P01112 41 R V ? P01112 41 R V ? ? possibly damaging alignment ? deleterious 0.879 0.0648 0.825 0.0962 NO NO ? +2.165 -1.428 -3.593 2 234 20 20 6q21 41 D 1.00 171 0.321 E B -33 1.64 0.95 ? ? ? 2 3.327 ? ? ? ? ? ? PF00071.17 11.006 ? 77.78 +P01112 41 R W ? P01112 41 R W C T probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.983 -1.428 -5.411 2 234 20 20 6q21 41 D 1.00 171 0.321 E B 54 1.67 0.95 ? ? ? 2 3.327 ? ? 0 0 1 -10 PF00071.17 0.516 ? 77.78 +P01112 41 R Y ? P01112 41 R Y ? ? possibly damaging alignment ? deleterious 0.951 0.0522 0.79 0.0823 NO NO ? +2.740 -1.428 -4.168 2 234 20 20 6q21 41 D 1.00 171 0.321 E B 20 1.41 0.95 ? ? ? 2 3.327 ? ? ? ? ? ? PF00071.17 2.887 ? 77.78 +P01112 42 K A ? P01112 42 K A ? ? probably damaging alignment ? deleterious 0.999 0.00574 0.136 0.0192 NO NO ? +2.050 -1.118 -3.168 2 235 20 20 6q21 42 D 1.00 171 0.239 E b -80 2.34 -0.07 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 3.863 ? 70.37 +P01112 42 K C ? P01112 42 K C ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +4.036 -1.118 -5.154 2 235 20 20 6q21 42 D 1.00 171 0.239 E b -60 2.8 -0.07 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 0.909 ? 70.37 +P01112 42 K D ? P01112 42 K D ? ? probably damaging alignment ? deleterious 0.999 0.00574 0.136 0.0192 NO NO ? +2.470 -1.118 -3.588 2 235 20 20 6q21 42 D 1.00 171 0.239 E b -57 1.59 -0.07 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 3.309 ? 70.37 +P01112 42 K E ? P01112 42 K E A G probably damaging alignment ? deleterious 0.988 0.0353 0.727 0.0617 NO NO ? +2.020 -1.118 -3.138 2 235 20 20 6q21 42 D 1.00 171 0.239 E b -30 1.3 -0.07 ? ? ? ? ? ? ? 0 0 0 -13 PF00071.17 7.104 ? 70.37 +P01112 42 K F ? P01112 42 K F ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.264 -1.118 -4.382 2 235 20 20 6q21 42 D 1.00 171 0.239 E b 22 2.92 -0.07 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.270 ? 70.37 +P01112 42 K G ? P01112 42 K G ? ? probably damaging alignment ? deleterious 0.999 0.00574 0.136 0.0192 NO NO ? +2.350 -1.118 -3.468 2 235 20 20 6q21 42 D 1.00 171 0.239 E b -108 2.05 -0.07 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.747 ? 70.37 +P01112 42 K H ? P01112 42 K H ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.386 -1.118 -4.504 2 235 20 20 6q21 42 D 1.00 171 0.239 E b -15 2.17 -0.07 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.106 ? 70.37 +P01112 42 K I ? P01112 42 K I ? ? probably damaging alignment ? deleterious 0.988 0.0353 0.727 0.0617 NO NO ? +2.959 -1.118 -4.077 2 235 20 20 6q21 42 D 1.00 171 0.239 E b -1 2.82 -0.07 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.634 ? 70.37 +P01112 42 K L ? P01112 42 K L ? ? probably damaging alignment ? deleterious 0.957 0.0496 0.784 0.079 NO NO ? +2.330 -1.118 -3.448 2 235 20 20 6q21 42 D 1.00 171 0.239 E b -1 2.89 -0.07 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 3.299 ? 70.37 +P01112 42 K M ? P01112 42 K M A T probably damaging alignment ? deleterious 0.999 0.00574 0.136 0.0192 NO NO ? +3.443 -1.118 -4.561 2 235 20 20 6q21 42 D 1.00 171 0.239 E b -5 2.89 -0.07 ? ? ? ? ? ? ? 1 1 0 -14 PF00071.17 1.486 ? 70.37 +P01112 42 K N ? P01112 42 K N G C probably damaging alignment ? deleterious 0.998 0.0112 0.273 0.0274 NO NO ? +2.440 -1.118 -3.558 2 235 20 20 6q21 42 D 1.00 171 0.239 E b -54 1.73 -0.07 ? ? ? ? ? ? ? 1 2 0 -15 PF00071.17 3.073 ? 70.37 +P01112 42 K P ? P01112 42 K P ? ? probably damaging alignment ? deleterious 0.999 0.00574 0.136 0.0192 NO NO ? +2.687 -1.118 -3.805 2 235 20 20 6q21 42 D 1.00 171 0.239 E b -56 1.82 -0.07 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.700 ? 70.37 +P01112 42 K Q ? P01112 42 K Q A C possibly damaging alignment ? deleterious 0.772 0.0757 0.849 0.108 NO NO ? +1.419 -1.118 -2.537 2 235 20 20 6q21 42 D 1.00 171 0.239 E b -24 1.7 -0.07 ? ? ? ? ? ? ? 1 0 0 -13 PF00071.17 14.715 14.715 70.37 +P01112 42 K R ? P01112 42 K R A G benign alignment ? neutral 0.179 0.129 0.918 0.16 NO NO ? +0.952 -1.118 -2.070 2 235 20 20 6q21 42 D 1.00 171 0.239 E b 5 1.14 -0.07 ? ? ? ? ? ? ? 0 1 0 -14 PF00071.17 24.210 24.210 70.37 +P01112 42 K S ? P01112 42 K S ? ? probably damaging alignment ? deleterious 0.997 0.0167 0.409 0.0357 NO NO ? +2.172 -1.118 -3.290 2 235 20 20 6q21 42 D 1.00 171 0.239 E b -79 2.07 -0.07 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 4.594 ? 70.37 +P01112 42 K T ? P01112 42 K T A C probably damaging alignment ? deleterious 0.961 0.048 0.78 0.077 NO NO ? +1.587 -1.118 -2.705 2 235 20 20 6q21 42 D 1.00 171 0.239 E b -52 2.12 -0.07 ? ? ? ? ? ? ? 1 1 2 -14 PF00071.17 12.231 12.231 70.37 +P01112 42 K V ? P01112 42 K V ? ? probably damaging alignment ? deleterious 0.967 0.046 0.773 0.0746 NO NO ? +2.515 -1.118 -3.633 2 235 20 20 6q21 42 D 1.00 171 0.239 E b -28 2.78 -0.07 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 3.558 ? 70.37 +P01112 42 K W ? P01112 42 K W ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +4.266 -1.118 -5.384 2 235 20 20 6q21 42 D 1.00 171 0.239 E b 59 2.81 -0.07 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 0.457 ? 70.37 +P01112 42 K Y ? P01112 42 K Y ? ? probably damaging alignment ? deleterious 0.999 0.00574 0.136 0.0192 NO NO ? +3.125 -1.118 -4.243 2 235 20 20 6q21 42 D 1.00 171 0.239 E b 25 2.55 -0.07 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.357 ? 70.37 +P01112 43 Q A ? P01112 43 Q A ? ? probably damaging alignment ? deleterious 0.997 0.0167 0.409 0.0357 NO NO ? +1.959 -1.301 -3.260 2 235 20 20 6q21 43 D 1.00 171 0.354 E B -56 0.64 -0.67 ? ? ? 6 2.922 ? ? ? ? ? ? PF00071.17 5.520 ? 70.37 +P01112 43 Q C ? P01112 43 Q C ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.922 -1.301 -5.223 2 235 20 20 6q21 43 D 1.00 171 0.354 E B -36 1.1 -0.67 ? ? ? 6 2.922 ? ? ? ? ? ? PF00071.17 0.730 ? 70.37 +P01112 43 Q D ? P01112 43 Q D ? ? possibly damaging alignment ? deleterious 0.8 0.0724 0.843 0.104 NO NO ? +1.154 -1.301 -2.455 2 235 20 20 6q21 43 D 1.00 171 0.354 E B -33 0.11 -0.67 ? ? ? 6 2.922 ? ? ? ? ? ? PF00071.17 17.842 17.842 70.37 +P01112 43 Q E ? P01112 43 Q E C G probably damaging alignment ? deleterious 0.983 0.0387 0.745 0.0657 NO NO ? +1.754 -1.301 -3.055 2 235 20 20 6q21 43 D 1.00 171 0.354 E B -6 0.4 -0.67 ? ? ? 6 2.922 ? ? 1 0 0 -16 PF00071.17 4.123 ? 70.37 +P01112 43 Q F ? P01112 43 Q F ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.050 -1.301 -4.351 2 235 20 20 6q21 43 D 1.00 171 0.354 E B 46 1.22 -0.67 ? ? ? 6 2.922 ? ? ? ? ? ? PF00071.17 1.996 ? 70.37 +P01112 43 Q G ? P01112 43 Q G ? ? possibly damaging alignment ? deleterious 0.756 0.0771 0.852 0.109 NO NO ? +1.330 -1.301 -2.631 2 235 20 20 6q21 43 D 1.00 171 0.354 E B -84 0.35 -0.67 ? ? ? 6 2.922 ? ? ? ? ? ? PF00071.17 35.879 35.879 70.37 +P01112 43 Q H ? P01112 43 Q H G C possibly damaging alignment ? neutral 0.482 0.0983 0.886 0.131 NO NO ? +1.237 -1.301 -2.538 2 235 20 20 6q21 43 D 1.00 171 0.354 E B 9 0.47 -0.67 ? ? ? 6 2.922 ? ? 1 2 2 -18 PF00071.17 22.853 22.853 70.37 +P01112 43 Q I ? P01112 43 Q I ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.859 -1.301 -4.160 2 235 20 20 6q21 43 D 1.00 171 0.354 E B 23 1.12 -0.67 ? ? ? 6 2.922 ? ? ? ? ? ? PF00071.17 1.430 ? 70.37 +P01112 43 Q K ? P01112 43 Q K C A probably damaging alignment ? deleterious 0.99 0.0338 0.719 0.06 NO NO ? +1.969 -1.301 -3.270 2 235 20 20 6q21 43 D 1.00 171 0.354 E B 24 1.7 -0.67 ? ? ? 6 2.922 ? ? 1 0 0 -16 PF00071.17 7.093 ? 70.37 +P01112 43 Q L ? P01112 43 Q L A T probably damaging alignment ? deleterious 0.995 0.0277 0.681 0.0521 NO NO ? +2.305 -1.301 -3.606 2 235 20 20 6q21 43 D 1.00 171 0.354 E B 23 1.19 -0.67 ? ? ? 6 2.922 ? ? 1 1 0 -17 PF00071.17 2.753 ? 70.37 +P01112 43 Q M ? P01112 43 Q M ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.283 -1.301 -4.584 2 235 20 20 6q21 43 D 1.00 171 0.354 E B 19 1.19 -0.67 ? ? ? 6 2.922 ? ? ? ? ? ? PF00071.17 0.942 ? 70.37 +P01112 43 Q N ? P01112 43 Q N ? ? probably damaging alignment ? deleterious 0.966 0.0465 0.775 0.0751 NO NO ? +1.449 -1.301 -2.750 2 235 20 20 6q21 43 D 1.00 171 0.354 E B -30 0.0299999999999999 -0.67 ? ? ? 6 2.922 ? ? ? ? ? ? PF00071.17 13.071 13.071 70.37 +P01112 43 Q P ? P01112 43 Q P A C probably damaging alignment ? deleterious 0.999 0.00574 0.136 0.0192 NO NO ? +2.563 -1.301 -3.864 2 235 20 20 6q21 43 D 1.00 171 0.354 E B -32 0.12 -0.67 ? ? ? 6 2.922 ? ? 1 1 2 -17 PF00071.17 1.295 ? 70.37 +P01112 43 Q R ? P01112 43 Q R A G possibly damaging alignment ? deleterious 0.597 0.0919 0.874 0.125 NO NO ? +1.486 -1.301 -2.787 2 235 20 20 6q21 43 D 1.00 171 0.354 E B 29 0.56 -0.67 ? ? ? 6 2.922 ? ? 0 1 2 -17 PF00071.17 20.206 20.206 70.37 +P01112 43 Q S ? P01112 43 Q S ? ? probably damaging alignment ? deleterious 0.998 0.0112 0.273 0.0274 NO NO ? +2.020 -1.301 -3.321 2 235 20 20 6q21 43 D 1.00 171 0.354 E B -55 0.37 -0.67 ? ? ? 6 2.922 ? ? ? ? ? ? PF00071.17 3.639 ? 70.37 +P01112 43 Q T ? P01112 43 Q T ? ? probably damaging alignment ? deleterious 0.981 0.0399 0.75 0.0672 NO NO ? +2.281 -1.301 -3.582 2 235 20 20 6q21 43 D 1.00 171 0.354 E B -28 0.42 -0.67 ? ? ? 6 2.922 ? ? ? ? ? ? PF00071.17 2.075 ? 70.37 +P01112 43 Q V ? P01112 43 Q V ? ? probably damaging alignment ? deleterious 0.994 0.0289 0.689 0.0537 NO NO ? +2.460 -1.301 -3.761 2 235 20 20 6q21 43 D 1.00 171 0.354 E B -4 1.08 -0.67 ? ? ? 6 2.922 ? ? ? ? ? ? PF00071.17 1.799 ? 70.37 +P01112 43 Q W ? P01112 43 Q W ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +4.013 -1.301 -5.314 2 235 20 20 6q21 43 D 1.00 171 0.354 E B 83 1.11 -0.67 ? ? ? 6 2.922 ? ? ? ? ? ? PF00071.17 0.387 ? 70.37 +P01112 43 Q Y ? P01112 43 Q Y ? ? probably damaging alignment ? deleterious 0.997 0.0167 0.409 0.0357 NO NO ? +2.730 -1.301 -4.031 2 235 20 20 6q21 43 D 1.00 171 0.354 E B 49 0.85 -0.67 ? ? ? 6 2.922 ? ? ? ? ? ? PF00071.17 3.746 ? 70.37 +P01112 44 V A ? P01112 44 V A T C benign alignment ? neutral 0.165 0.131 0.92 0.162 NO NO ? +0.841 -1.546 -2.387 2 235 20 20 6q21 44 D 1.00 171 0.208 E B -52 0.44 -0.84 ? ? ? ? ? ? ? 0 1 2 -20 PF00071.17 22.529 22.529 77.78 +P01112 44 V C ? P01112 44 V C ? ? benign alignment ? neutral 0.375 0.107 0.897 0.139 NO NO ? +1.123 -1.546 -2.669 2 235 20 20 6q21 44 D 1.00 171 0.208 E B -32 0.02 -0.84 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 27.617 27.617 77.78 +P01112 44 V D ? P01112 44 V D ? ? possibly damaging alignment ? deleterious 0.781 0.0747 0.848 0.107 NO NO ? +1.414 -1.546 -2.960 2 235 20 20 6q21 44 D 1.00 171 0.208 E B -29 1.19 -0.84 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 27.917 27.917 77.78 +P01112 44 V E ? P01112 44 V E T A possibly damaging alignment ? deleterious 0.95 0.0527 0.791 0.0828 NO NO ? +2.201 -1.546 -3.747 2 235 20 20 6q21 44 D 1.00 171 0.208 E B -2 1.48 -0.84 ? ? ? ? ? ? ? 1 1 0 -20 PF00071.17 6.451 ? 77.78 +P01112 44 V F ? P01112 44 V F ? ? probably damaging alignment ? deleterious 0.996 0.0222 0.545 0.0439 NO NO ? +2.524 -1.546 -4.070 2 235 20 20 6q21 44 D 1.00 171 0.208 E B 50 0.14 -0.84 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 3.503 ? 77.78 +P01112 44 V G ? P01112 44 V G T G probably damaging alignment ? deleterious 0.994 0.0289 0.689 0.0537 NO NO ? +2.070 -1.546 -3.616 2 235 20 20 6q21 44 D 1.00 171 0.208 E B -80 0.73 -0.84 ? ? ? ? ? ? ? 1 1 0 -20 PF00071.17 6.095 ? 77.78 +P01112 44 V H ? P01112 44 V H ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.414 -1.546 -4.960 2 235 20 20 6q21 44 D 1.00 171 0.208 E B 13 0.61 -0.84 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.252 ? 77.78 +P01112 44 V I ? P01112 44 V I ? ? benign alignment ? neutral 0.285 0.115 0.907 0.147 NO NO ? +1.149 -1.546 -2.695 2 235 20 20 6q21 44 D 1.00 171 0.208 E B 27 0.04 -0.84 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 15.372 15.372 77.78 +P01112 44 V K ? P01112 44 V K ? ? probably damaging alignment ? deleterious 0.991 0.0326 0.711 0.0584 NO NO ? +2.242 -1.546 -3.788 2 235 20 20 6q21 44 D 1.00 171 0.208 E B 28 2.78 -0.84 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 3.507 ? 77.78 +P01112 44 V L ? P01112 44 V L G C benign alignment ? neutral 0.231 0.121 0.912 0.152 NO NO ? +0.999 -1.546 -2.545 2 235 20 20 6q21 44 D 1.00 171 0.208 E B 27 0.11 -0.84 ? ? ? ? ? ? ? 1 0 0 -19 PF00071.17 18.676 18.676 77.78 +P01112 44 V M ? P01112 44 V M G A possibly damaging alignment ? deleterious 0.948 0.0532 0.793 0.0833 NO NO ? +1.668 -1.546 -3.214 2 235 20 20 6q21 44 D 1.00 171 0.208 E B 23 0.11 -0.84 ? ? ? ? ? ? ? 0 0 0 -19 PF00071.17 11.912 11.912 77.78 +P01112 44 V N ? P01112 44 V N ? ? possibly damaging alignment ? deleterious 0.891 0.0637 0.821 0.0952 NO NO ? +2.476 -1.546 -4.022 2 235 20 20 6q21 44 D 1.00 171 0.208 E B -26 1.05 -0.84 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 4.882 ? 77.78 +P01112 44 V P ? P01112 44 V P ? ? probably damaging alignment ? deleterious 0.971 0.0444 0.768 0.0727 NO NO ? +2.466 -1.546 -4.012 2 235 20 20 6q21 44 D 1.00 171 0.208 E B -28 0.96 -0.84 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.260 ? 77.78 +P01112 44 V Q ? P01112 44 V Q ? ? probably damaging alignment ? deleterious 0.994 0.0289 0.689 0.0537 NO NO ? +2.649 -1.546 -4.195 2 235 20 20 6q21 44 D 1.00 171 0.208 E B 4 1.08 -0.84 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.178 ? 77.78 +P01112 44 V R ? P01112 44 V R ? ? probably damaging alignment ? deleterious 0.998 0.0112 0.273 0.0274 NO NO ? +2.578 -1.546 -4.124 2 235 20 20 6q21 44 D 1.00 171 0.208 E B 33 1.64 -0.84 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.460 ? 77.78 +P01112 44 V S ? P01112 44 V S ? ? probably damaging alignment ? deleterious 0.984 0.0381 0.743 0.065 NO NO ? +1.933 -1.546 -3.479 2 235 20 20 6q21 44 D 1.00 171 0.208 E B -51 0.71 -0.84 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 6.553 ? 77.78 +P01112 44 V T ? P01112 44 V T ? ? benign alignment ? neutral 0.362 0.108 0.898 0.14 NO NO ? +0.516 -1.546 -2.062 2 235 20 20 6q21 44 D 1.00 171 0.208 E B -24 0.66 -0.84 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 13.271 13.271 77.78 +P01112 44 V W ? P01112 44 V W ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.835 -1.546 -5.381 2 235 20 20 6q21 44 D 1.00 171 0.208 E B 87 0.03 -0.84 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 0.585 ? 77.78 +P01112 44 V Y ? P01112 44 V Y ? ? probably damaging alignment ? deleterious 0.998 0.0112 0.273 0.0274 NO NO ? +2.669 -1.546 -4.215 2 235 20 20 6q21 44 D 1.00 171 0.208 E B 53 0.23 -0.84 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.682 ? 77.78 +P01112 45 V A ? P01112 45 V A T C benign alignment ? neutral 0.223 0.122 0.913 0.153 NO NO ? +1.110 -1.631 -2.741 2 235 20 20 6q21 45 D 1.00 171 0.492 E B -52 0.44 -0.75 ? ? ? 3 4.026 ? ? 0 1 0 -23 PF00071.17 19.004 19.004 76.19 +P01112 45 V C ? P01112 45 V C ? ? probably damaging alignment ? deleterious 0.998 0.0112 0.273 0.0274 NO NO ? +3.371 -1.631 -5.002 2 235 20 20 6q21 45 D 1.00 171 0.492 E B -32 0.02 -0.75 ? ? ? 3 4.026 ? ? ? ? ? ? PF00071.17 1.406 ? 76.19 +P01112 45 V D ? P01112 45 V D T A possibly damaging alignment ? deleterious 0.946 0.0537 0.795 0.0839 NO NO ? +2.189 -1.631 -3.820 2 235 20 20 6q21 45 D 1.00 171 0.492 E B -29 1.19 -0.75 ? ? ? 3 4.026 ? ? 1 1 0 -23 PF00071.17 6.349 ? 76.19 +P01112 45 V E ? P01112 45 V E ? ? benign alignment ? neutral 0.268 0.117 0.909 0.148 NO NO ? +1.389 -1.631 -3.020 2 235 20 20 6q21 45 D 1.00 171 0.492 E B -2 1.48 -0.75 ? ? ? 3 4.026 ? ? ? ? ? ? PF00071.17 14.774 14.774 76.19 +P01112 45 V F ? P01112 45 V F G T probably damaging alignment ? deleterious 0.963 0.0475 0.778 0.0764 NO NO ? +2.571 -1.631 -4.202 2 235 20 20 6q21 45 D 1.00 171 0.492 E B 50 0.14 -0.75 ? ? ? 3 4.026 ? ? 1 0 0 -22 PF00071.17 3.911 ? 76.19 +P01112 45 V G ? P01112 45 V G T G benign alignment ? neutral 0.182 0.128 0.918 0.159 NO NO ? +1.305 -1.631 -2.936 2 235 20 20 6q21 45 D 1.00 171 0.492 E B -80 0.73 -0.75 ? ? ? 3 4.026 ? ? 1 1 0 -23 PF00071.17 29.944 29.944 76.19 +P01112 45 V H ? P01112 45 V H ? ? probably damaging alignment ? deleterious 0.995 0.0277 0.681 0.0521 NO NO ? +3.218 -1.631 -4.849 2 235 20 20 6q21 45 D 1.00 171 0.492 E B 13 0.61 -0.75 ? ? ? 3 4.026 ? ? ? ? ? ? PF00071.17 2.441 ? 76.19 +P01112 45 V I ? P01112 45 V I G A benign alignment ? neutral 0.019 0.2 0.953 0.222 NO NO ? +0.942 -1.631 -2.573 2 235 20 20 6q21 45 D 1.00 171 0.492 E B 27 0.04 -0.75 ? ? ? 3 4.026 ? ? 0 0 0 -22 PF00071.17 15.372 15.372 76.19 +P01112 45 V K ? P01112 45 V K ? ? benign alignment ? neutral 0.444 0.1 0.89 0.133 NO NO ? +1.386 -1.631 -3.017 2 235 20 20 6q21 45 D 1.00 171 0.492 E B 28 2.78 -0.75 ? ? ? 3 4.026 ? ? ? ? ? ? PF00071.17 15.246 15.246 76.19 +P01112 45 V L ? P01112 45 V L G C benign alignment ? neutral 0.01 0.226 0.96 0.242 NO NO ? +1.103 -1.631 -2.734 2 235 20 20 6q21 45 D 1.00 171 0.492 E B 27 0.11 -0.75 ? ? ? 3 4.026 ? ? 1 0 0 -22 PF00071.17 26.823 26.823 76.19 +P01112 45 V M ? P01112 45 V M ? ? possibly damaging alignment ? deleterious 0.78 0.0747 0.848 0.107 NO NO ? +1.498 -1.631 -3.129 2 235 20 20 6q21 45 D 1.00 171 0.492 E B 23 0.11 -0.75 ? ? ? 3 4.026 ? ? ? ? ? ? PF00071.17 7.199 7.199 76.19 +P01112 45 V N ? P01112 45 V N ? ? benign alignment ? neutral 0.011 0.222 0.959 0.239 NO NO ? +1.276 -1.631 -2.907 2 235 20 20 6q21 45 D 1.00 171 0.492 E B -26 1.05 -0.75 ? ? ? 3 4.026 ? ? ? ? ? ? PF00071.17 24.131 24.131 76.19 +P01112 45 V P ? P01112 45 V P ? ? possibly damaging alignment ? deleterious 0.83 0.0692 0.837 0.101 NO NO ? +2.443 -1.631 -4.074 2 235 20 20 6q21 45 D 1.00 171 0.492 E B -28 0.96 -0.75 ? ? ? 3 4.026 ? ? ? ? ? ? PF00071.17 1.907 ? 76.19 +P01112 45 V Q ? P01112 45 V Q ? ? benign alignment ? neutral 0.405 0.105 0.894 0.137 NO NO ? +1.358 -1.631 -2.989 2 235 20 20 6q21 45 D 1.00 171 0.492 E B 4 1.08 -0.75 ? ? ? 3 4.026 ? ? ? ? ? ? PF00071.17 12.225 12.225 76.19 +P01112 45 V R ? P01112 45 V R ? ? possibly damaging alignment ? deleterious 0.63 0.0891 0.868 0.122 NO NO ? +1.559 -1.631 -3.190 2 235 20 20 6q21 45 D 1.00 171 0.492 E B 33 1.64 -0.75 ? ? ? 3 4.026 ? ? ? ? ? ? PF00071.17 14.198 14.198 76.19 +P01112 45 V S ? P01112 45 V S ? ? benign alignment ? neutral 0.275 0.116 0.908 0.147 NO NO ? +1.135 -1.631 -2.766 2 235 20 20 6q21 45 D 1.00 171 0.492 E B -51 0.71 -0.75 ? ? ? 3 4.026 ? ? ? ? ? ? PF00071.17 14.196 14.196 76.19 +P01112 45 V T ? P01112 45 V T ? ? benign alignment ? neutral 0.063 0.16 0.937 0.187 NO NO ? +0.938 -1.631 -2.569 2 235 20 20 6q21 45 D 1.00 171 0.492 E B -24 0.66 -0.75 ? ? ? 3 4.026 ? ? ? ? ? ? PF00071.17 16.394 16.394 76.19 +P01112 45 V W ? P01112 45 V W ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.865 -1.631 -5.496 2 235 20 20 6q21 45 D 1.00 171 0.492 E B 87 0.03 -0.75 ? ? ? 3 4.026 ? ? ? ? ? ? PF00071.17 0.529 ? 76.19 +P01112 45 V Y ? P01112 45 V Y ? ? probably damaging alignment ? deleterious 0.995 0.0277 0.681 0.0521 NO NO ? +2.660 -1.631 -4.291 2 235 20 20 6q21 45 D 1.00 171 0.492 E B 53 0.23 -0.75 ? ? ? 3 4.026 ? ? ? ? ? ? PF00071.17 1.596 ? 76.19 +P01112 46 I A ? P01112 46 I A ? ? probably damaging alignment ? deleterious 0.978 0.0417 0.756 0.0695 NO NO ? +1.150 -1.377 -2.527 2 235 20 20 6q21 46 D 1.00 171 0.023 E B -79 0.48 -0.77 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 12.567 12.567 70.37 +P01112 46 I C ? P01112 46 I C ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.392 -1.377 -4.769 2 235 20 20 6q21 46 D 1.00 171 0.023 E B -59 0.02 -0.77 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.165 ? 70.37 +P01112 46 I D ? P01112 46 I D ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.607 -1.377 -3.984 2 235 20 20 6q21 46 D 1.00 171 0.023 E B -56 1.23 -0.77 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.259 ? 70.37 +P01112 46 I E ? P01112 46 I E ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.471 -1.377 -3.848 2 235 20 20 6q21 46 D 1.00 171 0.023 E B -29 1.52 -0.77 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.596 ? 70.37 +P01112 46 I F ? P01112 46 I F A T probably damaging alignment ? deleterious 0.998 0.0112 0.273 0.0274 NO NO ? +2.506 -1.377 -3.883 2 235 20 20 6q21 46 D 1.00 171 0.023 E B 23 0.1 -0.77 ? ? ? ? ? ? ? 1 0 0 -25 PF00071.17 3.276 ? 70.37 +P01112 46 I G ? P01112 46 I G ? ? probably damaging alignment ? deleterious 0.999 0.00574 0.136 0.0192 NO NO ? +2.336 -1.377 -3.713 2 235 20 20 6q21 46 D 1.00 171 0.023 E B -107 0.77 -0.77 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 3.400 ? 70.37 +P01112 46 I H ? P01112 46 I H ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.598 -1.377 -4.975 2 235 20 20 6q21 46 D 1.00 171 0.023 E B -14 0.65 -0.77 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.053 ? 70.37 +P01112 46 I K ? P01112 46 I K ? ? probably damaging alignment ? deleterious 0.999 0.00574 0.136 0.0192 NO NO ? +2.469 -1.377 -3.846 2 235 20 20 6q21 46 D 1.00 171 0.023 E B 1 2.82 -0.77 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.880 ? 70.37 +P01112 46 I L ? P01112 46 I L A C benign alignment ? neutral 0.052 0.165 0.94 0.192 NO NO ? +1.365 -1.377 -2.742 2 235 20 20 6q21 46 D 1.00 171 0.023 E B 0 0.07 -0.77 ? ? ? ? ? ? ? 1 0 0 -25 PF00071.17 13.568 ? 70.37 +P01112 46 I M ? P01112 46 I M T G possibly damaging alignment ? deleterious 0.611 0.0911 0.872 0.124 NO NO ? +1.697 -1.377 -3.074 2 235 20 20 6q21 46 D 1.00 171 0.023 E B -4 0.07 -0.77 ? ? ? ? ? ? ? 1 2 0 -27 PF00071.17 11.141 11.141 70.37 +P01112 46 I N ? P01112 46 I N T A probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.816 -1.377 -4.193 2 235 20 20 6q21 46 D 1.00 171 0.023 E B -53 1.09 -0.77 ? ? ? ? ? ? ? 1 1 0 -26 PF00071.17 1.571 ? 70.37 +P01112 46 I P ? P01112 46 I P ? ? probably damaging structure 1.1.1 deleterious 0.996 0.0222 0.545 0.0439 NO NO ? +1.514 -1.377 -2.891 2 235 20 20 6q21 46 D 1.00 171 0.023 E B -55 1 -0.77 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 34.815 34.815 70.37 +P01112 46 I Q ? P01112 46 I Q ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.887 -1.377 -4.264 2 235 20 20 6q21 46 D 1.00 171 0.023 E B -23 1.12 -0.77 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.037 ? 70.37 +P01112 46 I R ? P01112 46 I R ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.808 -1.377 -4.185 2 235 20 20 6q21 46 D 1.00 171 0.023 E B 6 1.68 -0.77 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.210 ? 70.37 +P01112 46 I S ? P01112 46 I S T G probably damaging alignment ? deleterious 0.998 0.0112 0.273 0.0274 NO NO ? +2.255 -1.377 -3.632 2 235 20 20 6q21 46 D 1.00 171 0.023 E B -78 0.75 -0.77 ? ? ? ? ? ? ? 1 1 0 -26 PF00071.17 3.655 ? 70.37 +P01112 46 I T ? P01112 46 I T T C probably damaging alignment ? deleterious 0.994 0.0289 0.689 0.0537 NO NO ? +2.076 -1.377 -3.453 2 235 20 20 6q21 46 D 1.00 171 0.023 E B -51 0.7 -0.77 ? ? ? ? ? ? ? 0 1 0 -26 PF00071.17 3.117 ? 70.37 +P01112 46 I V ? P01112 46 I V A G benign alignment ? neutral 0.034 0.178 0.946 0.203 NO NO ? +0.220 -1.377 -1.597 2 235 20 20 6q21 46 D 1.00 171 0.023 E B -27 0.04 -0.77 ? ? ? ? ? ? ? 0 0 2 -25 PF00071.17 16.809 16.809 70.37 +P01112 46 I W ? P01112 46 I W ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +4.043 -1.377 -5.420 2 235 20 20 6q21 46 D 1.00 171 0.023 E B 60 0.01 -0.77 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 0.547 ? 70.37 +P01112 46 I Y ? P01112 46 I Y ? ? probably damaging alignment ? deleterious 0.995 0.0277 0.681 0.0521 NO NO ? +2.727 -1.377 -4.104 2 235 20 20 6q21 46 D 1.00 171 0.023 E B 26 0.27 -0.77 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.573 ? 70.37 +P01112 47 D A ? P01112 47 D A A C possibly damaging alignment ? deleterious 0.879 0.0648 0.825 0.0962 NO NO ? +1.536 -1.062 -2.598 2 235 20 20 6q21 47 D 1.00 171 0.537 T L -23 0.75 -0.27 ? ? ? 2 4.048 ? ? 1 1 0 -29 PF00071.17 20.384 20.384 77.78 +P01112 47 D C ? P01112 47 D C ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +4.031 -1.062 -5.093 2 235 20 20 6q21 47 D 1.00 171 0.537 T L -3 1.21 -0.27 ? ? ? 2 4.048 ? ? ? ? ? ? PF00071.17 1.508 ? 77.78 +P01112 47 D E ? P01112 47 D E T G probably damaging alignment ? deleterious 0.986 0.0368 0.736 0.0634 NO NO ? +2.003 -1.062 -3.065 2 235 20 20 6q21 47 D 1.00 171 0.537 T L 27 0.29 -0.27 ? ? ? 2 4.048 ? ? 1 2 0 -30 PF00071.17 3.850 ? 77.78 +P01112 47 D F ? P01112 47 D F ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.105 -1.062 -4.167 2 235 20 20 6q21 47 D 1.00 171 0.537 T L 79 1.33 -0.27 ? ? ? 2 4.048 ? ? ? ? ? ? PF00071.17 7.712 ? 77.78 +P01112 47 D G ? P01112 47 D G A G possibly damaging alignment ? deleterious 0.84 0.0683 0.836 0.0997 NO NO ? +1.410 -1.062 -2.472 2 235 20 20 6q21 47 D 1.00 171 0.537 T L -51 0.46 -0.27 ? ? ? 2 4.048 ? ? 0 1 0 -29 PF00071.17 36.418 36.418 77.78 +P01112 47 D H ? P01112 47 D H G C probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.385 -1.062 -4.447 2 235 20 20 6q21 47 D 1.00 171 0.537 T L 42 0.58 -0.27 ? ? ? 2 4.048 ? ? 1 0 0 -28 PF00071.17 2.768 ? 77.78 +P01112 47 D I ? P01112 47 D I ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.976 -1.062 -4.038 2 235 20 20 6q21 47 D 1.00 171 0.537 T L 56 1.23 -0.27 ? ? ? 2 4.048 ? ? ? ? ? ? PF00071.17 3.023 ? 77.78 +P01112 47 D K ? P01112 47 D K ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.497 -1.062 -3.559 2 235 20 20 6q21 47 D 1.00 171 0.537 T L 57 1.59 -0.27 ? ? ? 2 4.048 ? ? ? ? ? ? PF00071.17 4.251 ? 77.78 +P01112 47 D L ? P01112 47 D L ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.675 -1.062 -3.737 2 235 20 20 6q21 47 D 1.00 171 0.537 T L 56 1.3 -0.27 ? ? ? 2 4.048 ? ? ? ? ? ? PF00071.17 4.190 ? 77.78 +P01112 47 D M ? P01112 47 D M ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.852 -1.062 -4.914 2 235 20 20 6q21 47 D 1.00 171 0.537 T L 52 1.3 -0.27 ? ? ? 2 4.048 ? ? ? ? ? ? PF00071.17 1.272 ? 77.78 +P01112 47 D N ? P01112 47 D N G A possibly damaging alignment ? deleterious 0.571 0.0938 0.876 0.127 NO NO ? +1.352 -1.062 -2.414 2 235 20 20 6q21 47 D 1.00 171 0.537 T L 3 0.14 -0.27 ? ? ? 2 4.048 ? ? 0 0 0 -28 PF00071.17 24.634 24.634 77.78 +P01112 47 D P ? P01112 47 D P ? ? probably damaging alignment ? deleterious 0.998 0.0112 0.273 0.0274 NO NO ? +2.766 -1.062 -3.828 2 235 20 20 6q21 47 D 1.00 171 0.537 T L 1 0.23 -0.27 ? ? ? 2 4.048 ? ? ? ? ? ? PF00071.17 2.045 ? 77.78 +P01112 47 D Q ? P01112 47 D Q ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.777 -1.062 -3.839 2 235 20 20 6q21 47 D 1.00 171 0.537 T L 33 0.11 -0.27 ? ? ? 2 4.048 ? ? ? ? ? ? PF00071.17 2.666 ? 77.78 +P01112 47 D R ? P01112 47 D R ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.886 -1.062 -3.948 2 235 20 20 6q21 47 D 1.00 171 0.537 T L 62 0.45 -0.27 ? ? ? 2 4.048 ? ? ? ? ? ? PF00071.17 3.447 ? 77.78 +P01112 47 D S ? P01112 47 D S ? ? probably damaging alignment ? deleterious 0.998 0.0112 0.273 0.0274 NO NO ? +2.178 -1.062 -3.240 2 235 20 20 6q21 47 D 1.00 171 0.537 T L -22 0.48 -0.27 ? ? ? 2 4.048 ? ? ? ? ? ? PF00071.17 5.928 ? 77.78 +P01112 47 D T ? P01112 47 D T ? ? probably damaging alignment ? deleterious 0.997 0.0167 0.409 0.0357 NO NO ? +2.442 -1.062 -3.504 2 235 20 20 6q21 47 D 1.00 171 0.537 T L 5 0.53 -0.27 ? ? ? 2 4.048 ? ? ? ? ? ? PF00071.17 3.895 ? 77.78 +P01112 47 D V ? P01112 47 D V A T probably damaging alignment ? deleterious 0.995 0.0277 0.681 0.0521 NO NO ? +2.675 -1.062 -3.737 2 235 20 20 6q21 47 D 1.00 171 0.537 T L 29 1.19 -0.27 ? ? ? 2 4.048 ? ? 1 1 0 -29 PF00071.17 4.805 ? 77.78 +P01112 47 D W ? P01112 47 D W ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +4.324 -1.062 -5.386 2 235 20 20 6q21 47 D 1.00 171 0.537 T L 116 1.22 -0.27 ? ? ? 2 4.048 ? ? ? ? ? ? PF00071.17 1.615 ? 77.78 +P01112 47 D Y ? P01112 47 D Y G T probably damaging alignment ? deleterious 0.997 0.0167 0.409 0.0357 NO NO ? +1.905 -1.062 -2.967 2 235 20 20 6q21 47 D 1.00 171 0.537 T L 82 0.96 -0.27 ? ? ? 2 4.048 ? ? 1 0 0 -28 PF00071.17 18.641 18.641 77.78 +P01112 48 G A ? P01112 48 G A G C probably damaging alignment ? deleterious 0.993 0.0301 0.696 0.0553 NO NO ? +1.903 -1.261 -3.164 2 235 20 20 6q21 48 D 1.00 171 0.184 T l 28 0.29 0.31 ? ? ? 3 3.205 ? ? 1 1 2 -32 PF00071.17 4.291 ? 70.90 +P01112 48 G C ? P01112 48 G C ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.994 -1.261 -5.255 2 235 20 20 6q21 48 D 1.00 171 0.184 T l 48 0.75 0.31 ? ? ? 3 3.205 ? ? ? ? ? ? PF00071.17 1.074 ? 70.90 +P01112 48 G D ? P01112 48 G D ? ? benign alignment ? neutral 0.451 0.0999 0.889 0.132 NO NO ? +0.905 -1.261 -2.166 2 235 20 20 6q21 48 D 1.00 171 0.184 T l 51 0.46 0.31 ? ? ? 3 3.205 ? ? ? ? ? ? PF00071.17 28.127 28.127 70.90 +P01112 48 G E ? P01112 48 G E G A possibly damaging alignment ? deleterious 0.623 0.0897 0.87 0.123 NO NO ? +0.791 -1.261 -2.052 2 235 20 20 6q21 48 D 1.00 171 0.184 T l 78 0.75 0.31 ? ? ? 3 3.205 ? ? 0 1 0 -32 PF00071.17 19.804 19.804 70.90 +P01112 48 G F ? P01112 48 G F ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.180 -1.261 -4.441 2 235 20 20 6q21 48 D 1.00 171 0.184 T l 130 0.87 0.31 ? ? ? 3 3.205 ? ? ? ? ? ? PF00071.17 1.341 ? 70.90 +P01112 48 G H ? P01112 48 G H ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.375 -1.261 -4.636 2 235 20 20 6q21 48 D 1.00 171 0.184 T l 93 0.12 0.31 ? ? ? 3 3.205 ? ? ? ? ? ? PF00071.17 1.678 ? 70.90 +P01112 48 G I ? P01112 48 G I ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.967 -1.261 -4.228 2 235 20 20 6q21 48 D 1.00 171 0.184 T l 107 0.77 0.31 ? ? ? 3 3.205 ? ? ? ? ? ? PF00071.17 3.111 ? 70.90 +P01112 48 G K ? P01112 48 G K ? ? possibly damaging alignment ? deleterious 0.956 0.0501 0.785 0.0796 NO NO ? +1.331 -1.261 -2.592 2 235 20 20 6q21 48 D 1.00 171 0.184 T l 108 2.05 0.31 ? ? ? 3 3.205 ? ? ? ? ? ? PF00071.17 14.074 14.074 70.90 +P01112 48 G L ? P01112 48 G L ? ? probably damaging alignment ? deleterious 0.999 0.00574 0.136 0.0192 NO NO ? +2.548 -1.261 -3.809 2 235 20 20 6q21 48 D 1.00 171 0.184 T l 107 0.84 0.31 ? ? ? 3 3.205 ? ? ? ? ? ? PF00071.17 3.836 ? 70.90 +P01112 48 G M ? P01112 48 G M ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.691 -1.261 -4.952 2 235 20 20 6q21 48 D 1.00 171 0.184 T l 103 0.84 0.31 ? ? ? 3 3.205 ? ? ? ? ? ? PF00071.17 1.165 ? 70.90 +P01112 48 G N ? P01112 48 G N ? ? probably damaging alignment ? deleterious 0.993 0.0301 0.696 0.0553 NO NO ? +1.561 -1.261 -2.822 2 235 20 20 6q21 48 D 1.00 171 0.184 T l 54 0.32 0.31 ? ? ? 3 3.205 ? ? ? ? ? ? PF00071.17 13.071 13.071 70.90 +P01112 48 G P ? P01112 48 G P ? ? probably damaging alignment ? deleterious 0.999 0.00574 0.136 0.0192 NO NO ? +2.663 -1.261 -3.924 2 235 20 20 6q21 48 D 1.00 171 0.184 T l 52 0.23 0.31 ? ? ? 3 3.205 ? ? ? ? ? ? PF00071.17 1.745 ? 70.90 +P01112 48 G Q ? P01112 48 G Q ? ? probably damaging alignment ? deleterious 0.999 0.00574 0.136 0.0192 NO NO ? +2.615 -1.261 -3.876 2 235 20 20 6q21 48 D 1.00 171 0.184 T l 84 0.35 0.31 ? ? ? 3 3.205 ? ? ? ? ? ? PF00071.17 4.344 ? 70.90 +P01112 48 G R ? P01112 48 G R G A probably damaging alignment ? deleterious 0.998 0.0112 0.273 0.0274 NO NO ? +2.577 -1.261 -3.838 2 235 20 20 6q21 48 D 1.00 171 0.184 T l 113 0.91 0.31 ? ? ? 3 3.205 ? ? 0 0 0 -31 PF00071.17 5.445 ? 70.90 +P01112 48 G S ? P01112 48 G S ? ? probably damaging alignment ? deleterious 0.989 0.0346 0.723 0.0608 NO NO ? +2.033 -1.261 -3.294 2 235 20 20 6q21 48 D 1.00 171 0.184 T l 29 0.02 0.31 ? ? ? 3 3.205 ? ? ? ? ? ? PF00071.17 5.424 ? 70.90 +P01112 48 G T ? P01112 48 G T ? ? probably damaging alignment ? deleterious 0.981 0.0399 0.75 0.0672 NO NO ? +1.598 -1.261 -2.859 2 235 20 20 6q21 48 D 1.00 171 0.184 T l 56 0.07 0.31 ? ? ? 3 3.205 ? ? ? ? ? ? PF00071.17 14.442 14.442 70.90 +P01112 48 G V ? P01112 48 G V G T probably damaging alignment ? deleterious 0.999 0.00574 0.136 0.0192 NO NO ? +2.533 -1.261 -3.794 2 235 20 20 6q21 48 D 1.00 171 0.184 T l 80 0.73 0.31 ? ? ? 3 3.205 ? ? 1 1 0 -32 PF00071.17 4.201 ? 70.90 +P01112 48 G W ? P01112 48 G W G T probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +4.147 -1.261 -5.408 2 235 20 20 6q21 48 D 1.00 171 0.184 T l 167 0.76 0.31 ? ? ? 3 3.205 ? ? 1 0 0 -31 PF00071.17 0.330 ? 70.90 +P01112 48 G Y ? P01112 48 G Y ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.192 -1.261 -4.453 2 235 20 20 6q21 48 D 1.00 171 0.184 T l 133 0.5 0.31 ? ? ? 3 3.205 ? ? ? ? ? ? PF00071.17 1.087 ? 70.90 +P01112 49 E A ? P01112 49 E A A C possibly damaging structure 1.1.1 deleterious 0.542 0.0949 0.88 0.128 NO NO ? +1.277 -1.367 -2.644 2 235 20 20 6q21 49 D 1.00 171 0.112 E B -50 1.04 0.24 ? ? ? 4 4.203 ? ? 1 1 2 -35 PF00071.17 18.085 18.085 71.96 +P01112 49 E C ? P01112 49 E C ? ? probably damaging alignment ? deleterious 0.999 0.00574 0.136 0.0192 NO NO ? +3.841 -1.367 -5.208 2 235 20 20 6q21 49 D 1.00 171 0.112 E B -30 1.5 0.24 ? ? ? 4 4.203 ? ? ? ? ? ? PF00071.17 1.338 ? 71.96 +P01112 49 E D ? P01112 49 E D G C benign alignment ? neutral 0.015 0.209 0.956 0.229 NO NO ? +0.893 -1.367 -2.260 2 235 20 20 6q21 49 D 1.00 171 0.112 E B -27 0.29 0.24 ? ? ? 4 4.203 ? ? 1 2 0 -36 PF00071.17 28.547 28.547 71.96 +P01112 49 E F ? P01112 49 E F ? ? probably damaging alignment ? deleterious 0.999 0.00574 0.136 0.0192 NO NO ? +2.990 -1.367 -4.357 2 235 20 20 6q21 49 D 1.00 171 0.112 E B 52 1.62 0.24 ? ? ? 4 4.203 ? ? ? ? ? ? PF00071.17 2.176 ? 71.96 +P01112 49 E G ? P01112 49 E G A G probably damaging alignment ? deleterious 0.99 0.0338 0.719 0.06 NO NO ? +2.036 -1.367 -3.403 2 235 20 20 6q21 49 D 1.00 171 0.112 E B -78 0.75 0.24 ? ? ? 4 4.203 ? ? 0 1 0 -35 PF00071.17 4.893 ? 71.96 +P01112 49 E H ? P01112 49 E H ? ? possibly damaging alignment ? deleterious 0.541 0.0949 0.88 0.128 NO NO ? +1.808 -1.367 -3.175 2 235 20 20 6q21 49 D 1.00 171 0.112 E B 15 0.87 0.24 ? ? ? 4 4.203 ? ? ? ? ? ? PF00071.17 24.913 24.913 71.96 +P01112 49 E I ? P01112 49 E I ? ? probably damaging alignment ? deleterious 0.971 0.0444 0.768 0.0727 NO NO ? +2.599 -1.367 -3.966 2 235 20 20 6q21 49 D 1.00 171 0.112 E B 29 1.52 0.24 ? ? ? 4 4.203 ? ? ? ? ? ? PF00071.17 8.079 ? 71.96 +P01112 49 E K ? P01112 49 E K G A possibly damaging structure 1.1.1 neutral 0.489 0.0979 0.885 0.13 NO NO ? +0.965 -1.367 -2.332 2 235 20 20 6q21 49 D 1.00 171 0.112 E B 30 1.3 0.24 ? ? ? 4 4.203 ? ? 0 0 0 -34 PF00071.17 15.246 15.246 71.96 +P01112 49 E L ? P01112 49 E L ? ? probably damaging alignment ? deleterious 0.971 0.0444 0.768 0.0727 NO NO ? +2.240 -1.367 -3.607 2 235 20 20 6q21 49 D 1.00 171 0.112 E B 29 1.59 0.24 ? ? ? 4 4.203 ? ? ? ? ? ? PF00071.17 6.396 ? 71.96 +P01112 49 E M ? P01112 49 E M ? ? probably damaging alignment ? deleterious 0.996 0.0222 0.545 0.0439 NO NO ? +3.407 -1.367 -4.774 2 235 20 20 6q21 49 D 1.00 171 0.112 E B 25 1.59 0.24 ? ? ? 4 4.203 ? ? ? ? ? ? PF00071.17 1.560 ? 71.96 +P01112 49 E N ? P01112 49 E N ? ? possibly damaging alignment ? deleterious 0.605 0.0917 0.873 0.125 NO NO ? +1.465 -1.367 -2.832 2 235 20 20 6q21 49 D 1.00 171 0.112 E B -24 0.43 0.24 ? ? ? 4 4.203 ? ? ? ? ? ? PF00071.17 13.574 13.574 71.96 +P01112 49 E P ? P01112 49 E P ? ? possibly damaging alignment ? deleterious 0.953 0.0514 0.788 0.0812 NO NO ? +2.489 -1.367 -3.856 2 235 20 20 6q21 49 D 1.00 171 0.112 E B -26 0.52 0.24 ? ? ? 4 4.203 ? ? ? ? ? ? PF00071.17 1.814 ? 71.96 +P01112 49 E Q ? P01112 49 E Q G C probably damaging alignment ? deleterious 0.987 0.036 0.731 0.0626 NO NO ? +2.251 -1.367 -3.618 2 235 20 20 6q21 49 D 1.00 171 0.112 E B 6 0.4 0.24 ? ? ? 4 4.203 ? ? 1 0 0 -34 PF00071.17 2.930 ? 71.96 +P01112 49 E R ? P01112 49 E R ? ? probably damaging alignment ? deleterious 0.986 0.0368 0.736 0.0634 NO NO ? +2.309 -1.367 -3.676 2 235 20 20 6q21 49 D 1.00 171 0.112 E B 35 0.16 0.24 ? ? ? 4 4.203 ? ? ? ? ? ? PF00071.17 5.898 ? 71.96 +P01112 49 E S ? P01112 49 E S ? ? possibly damaging structure 1.1.1 deleterious 0.82 0.07 0.839 0.102 NO NO ? +1.352 -1.367 -2.719 2 235 20 20 6q21 49 D 1.00 171 0.112 E B -49 0.77 0.24 ? ? ? 4 4.203 ? ? ? ? ? ? PF00071.17 9.774 9.774 71.96 +P01112 49 E T ? P01112 49 E T ? ? probably damaging alignment ? deleterious 0.991 0.0326 0.711 0.0584 NO NO ? +2.149 -1.367 -3.516 2 235 20 20 6q21 49 D 1.00 171 0.112 E B -22 0.82 0.24 ? ? ? 4 4.203 ? ? ? ? ? ? PF00071.17 3.650 ? 71.96 +P01112 49 E V ? P01112 49 E V A T possibly damaging alignment ? deleterious 0.837 0.0686 0.836 0.1 NO NO ? +1.519 -1.367 -2.886 2 235 20 20 6q21 49 D 1.00 171 0.112 E B 2 1.48 0.24 ? ? ? 4 4.203 ? ? 1 1 0 -35 PF00071.17 13.248 13.248 71.96 +P01112 49 E W ? P01112 49 E W ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +4.140 -1.367 -5.507 2 235 20 20 6q21 49 D 1.00 171 0.112 E B 89 1.51 0.24 ? ? ? 4 4.203 ? ? ? ? ? ? PF00071.17 0.407 ? 71.96 +P01112 49 E Y ? P01112 49 E Y ? ? probably damaging alignment ? deleterious 0.999 0.00574 0.136 0.0192 NO NO ? +2.880 -1.367 -4.247 2 235 20 20 6q21 49 D 1.00 171 0.112 E B 55 1.25 0.24 ? ? ? 4 4.203 ? ? ? ? ? ? PF00071.17 4.084 ? 71.96 +P01112 50 T A ? P01112 50 T A A G benign alignment ? neutral 0.157 0.133 0.921 0.163 NO NO ? +1.033 -1.604 -2.637 2 235 20 20 6q21 50 D 1.00 171 0.014 E B -28 0.22 -0.35 ? ? ? 5 3.862 ? ? 0 0 0 -37 PF00071.17 18.698 18.698 73.54 +P01112 50 T C ? P01112 50 T C ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.393 -1.604 -4.997 2 235 20 20 6q21 50 D 1.00 171 0.014 E B -8 0.68 -0.35 ? ? ? 5 3.862 ? ? ? ? ? ? PF00071.17 1.383 ? 73.54 +P01112 50 T D ? P01112 50 T D ? ? possibly damaging alignment ? deleterious 0.88 0.0647 0.824 0.0961 NO NO ? +2.007 -1.604 -3.611 2 235 20 20 6q21 50 D 1.00 171 0.014 E B -5 0.53 -0.35 ? ? ? 5 3.862 ? ? ? ? ? ? PF00071.17 4.885 ? 73.54 +P01112 50 T E ? P01112 50 T E ? ? probably damaging alignment ? deleterious 0.968 0.0455 0.772 0.074 NO NO ? +1.227 -1.604 -2.831 2 235 20 20 6q21 50 D 1.00 171 0.014 E B 22 0.82 -0.35 ? ? ? 5 3.862 ? ? ? ? ? ? PF00071.17 16.032 16.032 73.54 +P01112 50 T F ? P01112 50 T F ? ? probably damaging alignment ? deleterious 0.999 0.00574 0.136 0.0192 NO NO ? +2.707 -1.604 -4.311 2 235 20 20 6q21 50 D 1.00 171 0.014 E B 74 0.8 -0.35 ? ? ? 5 3.862 ? ? ? ? ? ? PF00071.17 3.298 ? 73.54 +P01112 50 T G ? P01112 50 T G ? ? probably damaging alignment ? deleterious 0.984 0.0381 0.743 0.065 NO NO ? +1.915 -1.604 -3.519 2 235 20 20 6q21 50 D 1.00 171 0.014 E B -56 0.07 -0.35 ? ? ? 5 3.862 ? ? ? ? ? ? PF00071.17 5.058 ? 73.54 +P01112 50 T H ? P01112 50 T H ? ? probably damaging alignment ? deleterious 0.996 0.0222 0.545 0.0439 NO NO ? +3.113 -1.604 -4.717 2 235 20 20 6q21 50 D 1.00 171 0.014 E B 37 0.05 -0.35 ? ? ? 5 3.862 ? ? ? ? ? ? PF00071.17 1.409 ? 73.54 +P01112 50 T I ? P01112 50 T I ? ? possibly damaging alignment ? neutral 0.454 0.0996 0.889 0.132 NO NO ? +1.147 -1.604 -2.751 2 235 20 20 6q21 50 D 1.00 171 0.014 E B 51 0.7 -0.35 ? ? ? 5 3.862 ? ? ? ? ? ? PF00071.17 19.970 19.970 73.54 +P01112 50 T K ? P01112 50 T K C A probably damaging structure 1.1.1 deleterious 1 0.00026 0.00018 0.0109 NO NO ? +1.918 -1.604 -3.522 2 235 20 20 6q21 50 D 1.00 171 0.014 E B 52 2.12 -0.35 ? ? ? 5 3.862 ? ? 1 1 1 -38 PF00071.17 5.240 ? 73.54 +P01112 50 T L ? P01112 50 T L ? ? probably damaging alignment ? deleterious 0.991 0.0326 0.711 0.0584 NO NO ? +1.738 -1.604 -3.342 2 235 20 20 6q21 50 D 1.00 171 0.014 E B 51 0.77 -0.35 ? ? ? 5 3.862 ? ? ? ? ? ? PF00071.17 12.326 ? 73.54 +P01112 50 T M ? P01112 50 T M C T probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.009 -1.604 -4.613 2 235 20 20 6q21 50 D 1.00 171 0.014 E B 47 0.77 -0.35 ? ? ? 5 3.862 ? ? 0 1 1 -38 PF00071.17 2.716 ? 73.54 +P01112 50 T N ? P01112 50 T N ? ? possibly damaging alignment ? neutral 0.463 0.0994 0.888 0.132 NO NO ? +1.352 -1.604 -2.956 2 235 20 20 6q21 50 D 1.00 171 0.014 E B -2 0.39 -0.35 ? ? ? 5 3.862 ? ? ? ? ? ? PF00071.17 13.071 13.071 73.54 +P01112 50 T P ? P01112 50 T P A C benign alignment ? neutral 0.01 0.226 0.96 0.242 NO NO ? +0.534 -1.604 -2.138 2 235 20 20 6q21 50 D 1.00 171 0.014 E B -4 0.3 -0.35 ? ? ? 5 3.862 ? ? 1 0 0 -37 PF00071.17 34.815 34.815 73.54 +P01112 50 T Q ? P01112 50 T Q ? ? possibly damaging alignment ? deleterious 0.653 0.0873 0.866 0.12 NO NO ? +1.000 -1.604 -2.604 2 235 20 20 6q21 50 D 1.00 171 0.014 E B 28 0.42 -0.35 ? ? ? 5 3.862 ? ? ? ? ? ? PF00071.17 9.848 9.848 73.54 +P01112 50 T R ? P01112 50 T R C G probably damaging alignment ? deleterious 0.998 0.0112 0.273 0.0274 NO NO ? +1.408 -1.604 -3.012 2 235 20 20 6q21 50 D 1.00 171 0.014 E B 57 0.98 -0.35 ? ? ? 5 3.862 ? ? 1 1 1 -38 PF00071.17 14.927 14.927 73.54 +P01112 50 T S ? P01112 50 T S A T benign alignment ? neutral 0.339 0.11 0.901 0.142 NO NO ? +1.727 -1.604 -3.331 2 235 20 20 6q21 50 D 1.00 171 0.014 E B -27 0.05 -0.35 ? ? ? 5 3.862 ? ? 1 0 0 -37 PF00071.17 5.438 ? 73.54 +P01112 50 T V ? P01112 50 T V ? ? possibly damaging alignment ? deleterious 0.718 0.0806 0.857 0.113 NO NO ? +1.161 -1.604 -2.765 2 235 20 20 6q21 50 D 1.00 171 0.014 E B 24 0.66 -0.35 ? ? ? 5 3.862 ? ? ? ? ? ? PF00071.17 13.675 13.675 73.54 +P01112 50 T W ? P01112 50 T W ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.838 -1.604 -5.442 2 235 20 20 6q21 50 D 1.00 171 0.014 E B 111 0.69 -0.35 ? ? ? 5 3.862 ? ? ? ? ? ? PF00071.17 0.392 ? 73.54 +P01112 50 T Y ? P01112 50 T Y ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.713 -1.604 -4.317 2 235 20 20 6q21 50 D 1.00 171 0.014 E B 77 0.43 -0.35 ? ? ? 5 3.862 ? ? ? ? ? ? PF00071.17 1.497 ? 73.54 +P01112 51 C A ? P01112 51 C A ? ? probably damaging alignment ? deleterious 0.999 0.00574 0.136 0.0192 NO NO ? +1.841 -1.221 -3.062 2 234 20 20 6q21 51 D 1.00 171 0.000 E B -20 0.46 -0.61 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 3.530 ? 68.78 +P01112 51 C D ? P01112 51 C D ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.778 -1.221 -3.999 2 234 20 20 6q21 51 D 1.00 171 0.000 E B 3 1.21 -0.61 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.114 ? 68.78 +P01112 51 C E ? P01112 51 C E ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.721 -1.221 -3.942 2 234 20 20 6q21 51 D 1.00 171 0.000 E B 30 1.5 -0.61 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 3.589 ? 68.78 +P01112 51 C F ? P01112 51 C F G T probably damaging alignment ? deleterious 0.999 0.00574 0.136 0.0192 NO NO ? +2.618 -1.221 -3.839 2 234 20 20 6q21 51 D 1.00 171 0.000 E B 82 0.12 -0.61 ? ? ? ? ? ? ? 1 1 0 -41 PF00071.17 6.670 ? 68.78 +P01112 51 C G ? P01112 51 C G T G probably damaging alignment ? deleterious 0.999 0.00574 0.136 0.0192 NO NO ? +2.443 -1.221 -3.664 2 234 20 20 6q21 51 D 1.00 171 0.000 E B -48 0.75 -0.61 ? ? ? ? ? ? ? 1 0 0 -40 PF00071.17 2.295 ? 68.78 +P01112 51 C H ? P01112 51 C H ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.376 -1.221 -4.597 2 234 20 20 6q21 51 D 1.00 171 0.000 E B 45 0.63 -0.61 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.394 ? 68.78 +P01112 51 C I ? P01112 51 C I ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.380 -1.221 -3.601 2 234 20 20 6q21 51 D 1.00 171 0.000 E B 59 0.02 -0.61 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 8.340 ? 68.78 +P01112 51 C K ? P01112 51 C K ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.523 -1.221 -3.744 2 234 20 20 6q21 51 D 1.00 171 0.000 E B 60 2.8 -0.61 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 8.308 ? 68.78 +P01112 51 C L ? P01112 51 C L ? ? probably damaging alignment ? deleterious 0.999 0.00574 0.136 0.0192 NO NO ? +2.001 -1.221 -3.222 2 234 20 20 6q21 51 D 1.00 171 0.000 E B 59 0.09 -0.61 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 6.603 ? 68.78 +P01112 51 C M ? P01112 51 C M ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.325 -1.221 -4.546 2 234 20 20 6q21 51 D 1.00 171 0.000 E B 55 0.09 -0.61 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.611 ? 68.78 +P01112 51 C N ? P01112 51 C N ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.861 -1.221 -4.082 2 234 20 20 6q21 51 D 1.00 171 0.000 E B 6 1.07 -0.61 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.637 ? 68.78 +P01112 51 C P ? P01112 51 C P ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.945 -1.221 -4.166 2 234 20 20 6q21 51 D 1.00 171 0.000 E B 4 0.98 -0.61 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.276 ? 68.78 +P01112 51 C Q ? P01112 51 C Q ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.974 -1.221 -4.195 2 234 20 20 6q21 51 D 1.00 171 0.000 E B 36 1.1 -0.61 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 3.313 ? 68.78 +P01112 51 C R ? P01112 51 C R T C probably damaging structure 1.1.1 deleterious 0.999 0.00574 0.136 0.0192 NO NO ? +1.444 -1.221 -2.665 2 234 20 20 6q21 51 D 1.00 171 0.000 E B 65 1.66 -0.61 ? ? ? ? ? ? ? 0 0 2 -40 PF00071.17 23.664 23.664 68.78 +P01112 51 C S ? P01112 51 C S T A probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.331 -1.221 -3.552 2 234 20 20 6q21 51 D 1.00 171 0.000 E B -19 0.73 -0.61 ? ? ? ? ? ? ? 1 0 0 -40 PF00071.17 3.020 ? 68.78 +P01112 51 C T ? P01112 51 C T ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.330 -1.221 -3.551 2 234 20 20 6q21 51 D 1.00 171 0.000 E B 8 0.68 -0.61 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.536 ? 68.78 +P01112 51 C V ? P01112 51 C V ? ? probably damaging alignment ? deleterious 0.993 0.0301 0.696 0.0553 NO NO ? +1.468 -1.221 -2.689 2 234 20 20 6q21 51 D 1.00 171 0.000 E B 32 0.02 -0.61 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 13.675 13.675 68.78 +P01112 51 C W ? P01112 51 C W C G probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.766 -1.221 -4.987 2 234 20 20 6q21 51 D 1.00 171 0.000 E B 119 0.01 -0.61 ? ? ? ? ? ? ? 1 2 0 -42 PF00071.17 1.396 ? 68.78 +P01112 51 C Y ? P01112 51 C Y G A probably damaging structure 1.1.2 deleterious 0.998 0.0112 0.273 0.0274 NO NO ? +0.988 -1.221 -2.209 2 234 20 20 6q21 51 D 1.00 171 0.000 E B 85 0.25 -0.61 ? ? ? ? ? ? ? 0 1 0 -41 PF00071.17 16.122 16.122 68.78 +P01112 52 L A ? P01112 52 L A ? ? probably damaging alignment ? deleterious 0.984 0.0381 0.743 0.065 NO NO ? +1.738 -1.458 -3.196 2 234 20 20 6q21 52 D 1.00 171 0.117 E B -79 0.55 -0.75 ? ? ? 1 3.412 ? ? ? ? ? ? PF00071.17 5.258 ? 76.19 +P01112 52 L C ? P01112 52 L C ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.439 -1.458 -4.897 2 234 20 20 6q21 52 D 1.00 171 0.117 E B -59 0.09 -0.75 ? ? ? 1 3.412 ? ? ? ? ? ? PF00071.17 1.412 ? 76.19 +P01112 52 L D ? P01112 52 L D ? ? probably damaging alignment ? deleterious 0.999 0.00574 0.136 0.0192 NO NO ? +2.446 -1.458 -3.904 2 234 20 20 6q21 52 D 1.00 171 0.117 E B -56 1.3 -0.75 ? ? ? 1 3.412 ? ? ? ? ? ? PF00071.17 2.444 ? 76.19 +P01112 52 L E ? P01112 52 L E ? ? probably damaging alignment ? deleterious 0.994 0.0289 0.689 0.0537 NO NO ? +2.191 -1.458 -3.649 2 234 20 20 6q21 52 D 1.00 171 0.117 E B -29 1.59 -0.75 ? ? ? 1 3.412 ? ? ? ? ? ? PF00071.17 5.246 ? 76.19 +P01112 52 L F ? P01112 52 L F ? ? benign alignment ? neutral 0.443 0.1 0.89 0.133 NO NO ? +1.240 -1.458 -2.698 2 234 20 20 6q21 52 D 1.00 171 0.117 E B 23 0.03 -0.75 ? ? ? 1 3.412 ? ? ? ? ? ? PF00071.17 26.309 26.309 76.19 +P01112 52 L G ? P01112 52 L G ? ? probably damaging alignment ? deleterious 0.998 0.0112 0.273 0.0274 NO NO ? +2.246 -1.458 -3.704 2 234 20 20 6q21 52 D 1.00 171 0.117 E B -107 0.84 -0.75 ? ? ? 1 3.412 ? ? ? ? ? ? PF00071.17 2.765 ? 76.19 +P01112 52 L H ? P01112 52 L H ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.343 -1.458 -4.801 2 234 20 20 6q21 52 D 1.00 171 0.117 E B -14 0.72 -0.75 ? ? ? 1 3.412 ? ? ? ? ? ? PF00071.17 1.555 ? 76.19 +P01112 52 L I ? P01112 52 L I ? ? benign alignment ? neutral 0.201 0.125 0.916 0.156 NO NO ? +1.257 -1.458 -2.715 2 234 20 20 6q21 52 D 1.00 171 0.117 E B 0 0.07 -0.75 ? ? ? 1 3.412 ? ? ? ? ? ? PF00071.17 16.953 16.953 76.19 +P01112 52 L K ? P01112 52 L K ? ? possibly damaging alignment ? deleterious 0.861 0.0665 0.83 0.0979 NO NO ? +2.191 -1.458 -3.649 2 234 20 20 6q21 52 D 1.00 171 0.117 E B 1 2.89 -0.75 ? ? ? 1 3.412 ? ? ? ? ? ? PF00071.17 4.591 ? 76.19 +P01112 52 L M ? P01112 52 L M C A possibly damaging alignment ? deleterious 0.844 0.0677 0.835 0.099 NO NO ? +1.378 -1.458 -2.836 2 234 20 20 6q21 52 D 1.00 171 0.117 E B -4 0 -0.75 ? ? ? 1 3.412 ? ? 1 0 0 -43 PF00071.17 12.341 12.341 76.19 +P01112 52 L N ? P01112 52 L N ? ? probably damaging alignment ? deleterious 0.999 0.00574 0.136 0.0192 NO NO ? +2.559 -1.458 -4.017 2 234 20 20 6q21 52 D 1.00 171 0.117 E B -53 1.16 -0.75 ? ? ? 1 3.412 ? ? ? ? ? ? PF00071.17 2.269 ? 76.19 +P01112 52 L P ? P01112 52 L P T C possibly damaging alignment ? deleterious 0.785 0.0744 0.847 0.106 NO NO ? +1.503 -1.458 -2.961 2 234 20 20 6q21 52 D 1.00 171 0.117 E B -55 1.07 -0.75 ? ? ? 1 3.412 ? ? 0 1 2 -44 PF00071.17 24.606 24.606 76.19 +P01112 52 L Q ? P01112 52 L Q T A possibly damaging structure 1.1.1 deleterious 0.772 0.0757 0.849 0.108 NO NO ? +0.921 -1.458 -2.379 2 234 20 20 6q21 52 D 1.00 171 0.117 E B -23 1.19 -0.75 ? ? ? 1 3.412 ? ? 1 1 0 -44 PF00071.17 10.866 10.866 76.19 +P01112 52 L R ? P01112 52 L R T G probably damaging alignment ? deleterious 0.992 0.0314 0.704 0.0568 NO NO ? +2.485 -1.458 -3.943 2 234 20 20 6q21 52 D 1.00 171 0.117 E B 6 1.75 -0.75 ? ? ? 1 3.412 ? ? 1 1 2 -44 PF00071.17 3.686 ? 76.19 +P01112 52 L S ? P01112 52 L S ? ? probably damaging structure 1.1.1 deleterious 0.984 0.0381 0.743 0.065 NO NO ? +1.385 -1.458 -2.843 2 234 20 20 6q21 52 D 1.00 171 0.117 E B -78 0.82 -0.75 ? ? ? 1 3.412 ? ? ? ? ? ? PF00071.17 9.076 9.076 76.19 +P01112 52 L T ? P01112 52 L T ? ? probably damaging alignment ? deleterious 0.992 0.0314 0.704 0.0568 NO NO ? +2.082 -1.458 -3.540 2 234 20 20 6q21 52 D 1.00 171 0.117 E B -51 0.77 -0.75 ? ? ? 1 3.412 ? ? ? ? ? ? PF00071.17 3.777 ? 76.19 +P01112 52 L V ? P01112 52 L V C G benign alignment ? neutral 0.055 0.163 0.94 0.191 NO NO ? +1.157 -1.458 -2.615 2 234 20 20 6q21 52 D 1.00 171 0.117 E B -27 0.11 -0.75 ? ? ? 1 3.412 ? ? 1 0 2 -43 PF00071.17 20.370 20.370 76.19 +P01112 52 L W ? P01112 52 L W ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.737 -1.458 -5.195 2 234 20 20 6q21 52 D 1.00 171 0.117 E B 60 0.08 -0.75 ? ? ? 1 3.412 ? ? ? ? ? ? PF00071.17 1.222 ? 76.19 +P01112 52 L Y ? P01112 52 L Y ? ? possibly damaging alignment ? deleterious 0.908 0.0613 0.815 0.0925 NO NO ? +2.530 -1.458 -3.988 2 234 20 20 6q21 52 D 1.00 171 0.117 E B 26 0.34 -0.75 ? ? ? 1 3.412 ? ? ? ? ? ? PF00071.17 6.102 ? 76.19 +P01112 53 L A ? P01112 53 L A ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.313 -0.872 -3.185 2 235 20 20 6q21 53 D 1.00 171 0.000 E B -79 0.55 -0.95 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 3.179 ? 71.43 +P01112 53 L C ? P01112 53 L C ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.857 -0.872 -4.729 2 235 20 20 6q21 53 D 1.00 171 0.000 E B -59 0.09 -0.95 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.093 ? 71.43 +P01112 53 L D ? P01112 53 L D ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.322 -0.872 -4.194 2 235 20 20 6q21 53 D 1.00 171 0.000 E B -56 1.3 -0.95 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.231 ? 71.43 +P01112 53 L E ? P01112 53 L E ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.091 -0.872 -3.963 2 235 20 20 6q21 53 D 1.00 171 0.000 E B -29 1.59 -0.95 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.452 ? 71.43 +P01112 53 L F ? P01112 53 L F G C probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.795 -0.872 -3.667 2 235 20 20 6q21 53 D 1.00 171 0.000 E B 23 0.03 -0.95 ? ? ? ? ? ? ? 1 2 2 -48 PF00071.17 4.655 ? 71.43 +P01112 53 L G ? P01112 53 L G ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.958 -0.872 -3.830 2 235 20 20 6q21 53 D 1.00 171 0.000 E B -107 0.84 -0.95 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.233 ? 71.43 +P01112 53 L H ? P01112 53 L H ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +4.083 -0.872 -4.955 2 235 20 20 6q21 53 D 1.00 171 0.000 E B -14 0.72 -0.95 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 0.831 ? 71.43 +P01112 53 L I ? P01112 53 L I ? ? probably damaging alignment ? deleterious 0.975 0.0436 0.762 0.072 NO NO ? +1.584 -0.872 -2.456 2 235 20 20 6q21 53 D 1.00 171 0.000 E B 0 0.07 -0.95 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 18.389 18.389 71.43 +P01112 53 L K ? P01112 53 L K ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.921 -0.872 -3.793 2 235 20 20 6q21 53 D 1.00 171 0.000 E B 1 2.89 -0.95 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.561 ? 71.43 +P01112 53 L M ? P01112 53 L M T A probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.072 -0.872 -3.944 2 235 20 20 6q21 53 D 1.00 171 0.000 E B -4 0 -0.95 ? ? ? ? ? ? ? 1 0 0 -46 PF00071.17 2.501 ? 71.43 +P01112 53 L N ? P01112 53 L N ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.343 -0.872 -4.215 2 235 20 20 6q21 53 D 1.00 171 0.000 E B -53 1.16 -0.95 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 0.992 ? 71.43 +P01112 53 L P ? P01112 53 L P ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.324 -0.872 -4.196 2 235 20 20 6q21 53 D 1.00 171 0.000 E B -55 1.07 -0.95 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.004 ? 71.43 +P01112 53 L Q ? P01112 53 L Q ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.344 -0.872 -4.216 2 235 20 20 6q21 53 D 1.00 171 0.000 E B -23 1.19 -0.95 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.246 ? 71.43 +P01112 53 L R ? P01112 53 L R ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.172 -0.872 -4.044 2 235 20 20 6q21 53 D 1.00 171 0.000 E B 6 1.75 -0.95 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.457 ? 71.43 +P01112 53 L S ? P01112 53 L S T C probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.830 -0.872 -3.702 2 235 20 20 6q21 53 D 1.00 171 0.000 E B -78 0.82 -0.95 ? ? ? ? ? ? ? 0 1 2 -47 PF00071.17 1.718 ? 71.43 +P01112 53 L T ? P01112 53 L T ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.641 -0.872 -3.513 2 235 20 20 6q21 53 D 1.00 171 0.000 E B -51 0.77 -0.95 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.688 ? 71.43 +P01112 53 L V ? P01112 53 L V T G probably damaging alignment ? deleterious 0.997 0.0167 0.409 0.0357 NO NO ? +2.057 -0.872 -2.929 2 235 20 20 6q21 53 D 1.00 171 0.000 E B -27 0.11 -0.95 ? ? ? ? ? ? ? 1 0 0 -46 PF00071.17 11.939 ? 71.43 +P01112 53 L W ? P01112 53 L W T G probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.141 -0.872 -3.013 2 235 20 20 6q21 53 D 1.00 171 0.000 E B 60 0.08 -0.95 ? ? ? ? ? ? ? 1 1 0 -47 PF00071.17 35.467 35.467 71.43 +P01112 53 L Y ? P01112 53 L Y ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.054 -0.872 -3.926 2 235 20 20 6q21 53 D 1.00 171 0.000 E B 26 0.34 -0.95 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 4.865 ? 71.43 +P01112 54 D A ? P01112 54 D A A C possibly damaging alignment ? deleterious 0.73 0.0795 0.855 0.112 NO NO ? +1.513 -1.167 -2.680 2 236 20 20 6q21 54 D 1.00 171 0.232 E B -23 0.75 -0.33 ? ? ? ? ? ? ? 1 1 0 -50 PF00071.17 20.690 20.690 71.43 +P01112 54 D C ? P01112 54 D C ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.987 -1.167 -5.154 2 236 20 20 6q21 54 D 1.00 171 0.232 E B -3 1.21 -0.33 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.531 ? 71.43 +P01112 54 D E ? P01112 54 D E C G possibly damaging alignment ? deleterious 0.566 0.0939 0.877 0.127 NO NO ? +1.377 -1.167 -2.544 2 236 20 20 6q21 54 D 1.00 171 0.232 E B 27 0.29 -0.33 ? ? ? ? ? ? ? 1 2 0 -51 PF00071.17 16.346 16.346 71.43 +P01112 54 D F ? P01112 54 D F ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.032 -1.167 -4.199 2 236 20 20 6q21 54 D 1.00 171 0.232 E B 79 1.33 -0.33 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 5.975 ? 71.43 +P01112 54 D G ? P01112 54 D G A G probably damaging alignment ? deleterious 0.988 0.0353 0.727 0.0617 NO NO ? +2.126 -1.167 -3.293 2 236 20 20 6q21 54 D 1.00 171 0.232 E B -51 0.46 -0.33 ? ? ? ? ? ? ? 0 1 0 -50 PF00071.17 5.597 ? 71.43 +P01112 54 D H ? P01112 54 D H G C probably damaging alignment ? deleterious 0.982 0.0393 0.748 0.0664 NO NO ? +1.930 -1.167 -3.097 2 236 20 20 6q21 54 D 1.00 171 0.232 E B 42 0.58 -0.33 ? ? ? ? ? ? ? 1 0 0 -49 PF00071.17 15.173 15.173 71.43 +P01112 54 D I ? P01112 54 D I ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.903 -1.167 -4.070 2 236 20 20 6q21 54 D 1.00 171 0.232 E B 56 1.23 -0.33 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 3.068 ? 71.43 +P01112 54 D K ? P01112 54 D K ? ? probably damaging alignment ? deleterious 0.998 0.0112 0.273 0.0274 NO NO ? +2.313 -1.167 -3.480 2 236 20 20 6q21 54 D 1.00 171 0.232 E B 57 1.59 -0.33 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 5.432 ? 71.43 +P01112 54 D L ? P01112 54 D L ? ? probably damaging alignment ? deleterious 0.999 0.00574 0.136 0.0192 NO NO ? +2.565 -1.167 -3.732 2 236 20 20 6q21 54 D 1.00 171 0.232 E B 56 1.3 -0.33 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 4.253 ? 71.43 +P01112 54 D M ? P01112 54 D M ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.732 -1.167 -4.899 2 236 20 20 6q21 54 D 1.00 171 0.232 E B 52 1.3 -0.33 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.291 ? 71.43 +P01112 54 D N ? P01112 54 D N G A benign alignment ? neutral 0.332 0.111 0.902 0.143 NO NO ? +1.330 -1.167 -2.497 2 236 20 20 6q21 54 D 1.00 171 0.232 E B 3 0.14 -0.33 ? ? ? ? ? ? ? 0 0 0 -49 PF00071.17 21.450 21.450 71.43 +P01112 54 D P ? P01112 54 D P ? ? probably damaging alignment ? deleterious 0.978 0.0417 0.756 0.0695 NO NO ? +2.701 -1.167 -3.868 2 236 20 20 6q21 54 D 1.00 171 0.232 E B 1 0.23 -0.33 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.076 ? 71.43 +P01112 54 D Q ? P01112 54 D Q ? ? probably damaging alignment ? deleterious 0.998 0.0112 0.273 0.0274 NO NO ? +2.614 -1.167 -3.781 2 236 20 20 6q21 54 D 1.00 171 0.232 E B 33 0.11 -0.33 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 3.585 ? 71.43 +P01112 54 D R ? P01112 54 D R ? ? probably damaging alignment ? deleterious 0.982 0.0393 0.748 0.0664 NO NO ? +1.766 -1.167 -2.933 2 236 20 20 6q21 54 D 1.00 171 0.232 E B 62 0.45 -0.33 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 15.473 15.473 71.43 +P01112 54 D S ? P01112 54 D S ? ? probably damaging alignment ? deleterious 0.994 0.0289 0.689 0.0537 NO NO ? +2.139 -1.167 -3.306 2 236 20 20 6q21 54 D 1.00 171 0.232 E B -22 0.48 -0.33 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 6.018 ? 71.43 +P01112 54 D T ? P01112 54 D T ? ? probably damaging alignment ? deleterious 0.993 0.0301 0.696 0.0553 NO NO ? +2.374 -1.167 -3.541 2 236 20 20 6q21 54 D 1.00 171 0.232 E B 5 0.53 -0.33 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 3.578 ? 71.43 +P01112 54 D V ? P01112 54 D V A T probably damaging alignment ? deleterious 0.987 0.036 0.731 0.0626 NO NO ? +2.605 -1.167 -3.772 2 236 20 20 6q21 54 D 1.00 171 0.232 E B 29 1.19 -0.33 ? ? ? ? ? ? ? 1 1 0 -50 PF00071.17 4.878 ? 71.43 +P01112 54 D W ? P01112 54 D W ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +4.260 -1.167 -5.427 2 236 20 20 6q21 54 D 1.00 171 0.232 E B 116 1.22 -0.33 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.251 ? 71.43 +P01112 54 D Y ? P01112 54 D Y G T probably damaging alignment ? deleterious 0.993 0.0301 0.696 0.0553 NO NO ? +1.857 -1.167 -3.024 2 236 20 20 6q21 54 D 1.00 171 0.232 E B 82 0.96 -0.33 ? ? ? ? ? ? ? 1 0 0 -49 PF00071.17 14.442 14.442 71.43 +P01112 55 I A ? P01112 55 I A ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.225 -0.904 -3.129 2 236 20 20 6q21 55 D 1.00 171 0.000 E B -79 0.48 -0.42 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 3.026 ? 67.72 +P01112 55 I C ? P01112 55 I C ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.785 -0.904 -4.689 2 236 20 20 6q21 55 D 1.00 171 0.000 E B -59 0.02 -0.42 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.074 ? 67.72 +P01112 55 I D ? P01112 55 I D ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.087 -0.904 -3.991 2 236 20 20 6q21 55 D 1.00 171 0.000 E B -56 1.23 -0.42 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.041 ? 67.72 +P01112 55 I E ? P01112 55 I E ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.037 -0.904 -3.941 2 236 20 20 6q21 55 D 1.00 171 0.000 E B -29 1.52 -0.42 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.372 ? 67.72 +P01112 55 I F ? P01112 55 I F A T probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.765 -0.904 -3.669 2 236 20 20 6q21 55 D 1.00 171 0.000 E B 23 0.1 -0.42 ? ? ? ? ? ? ? 1 0 0 -52 PF00071.17 3.708 ? 67.72 +P01112 55 I G ? P01112 55 I G ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.956 -0.904 -3.860 2 236 20 20 6q21 55 D 1.00 171 0.000 E B -107 0.77 -0.42 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.429 ? 67.72 +P01112 55 I H ? P01112 55 I H ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +4.053 -0.904 -4.957 2 236 20 20 6q21 55 D 1.00 171 0.000 E B -14 0.65 -0.42 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 0.676 ? 67.72 +P01112 55 I K ? P01112 55 I K ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.029 -0.904 -3.933 2 236 20 20 6q21 55 D 1.00 171 0.000 E B 1 2.82 -0.42 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.687 ? 67.72 +P01112 55 I L ? P01112 55 I L A C possibly damaging alignment ? deleterious 0.52 0.096 0.882 0.129 NO NO ? +1.196 -0.904 -2.100 2 236 20 20 6q21 55 D 1.00 171 0.000 E B 0 0.07 -0.42 ? ? ? ? ? ? ? 1 0 0 -52 PF00071.17 25.432 25.432 67.72 +P01112 55 I M ? P01112 55 I M C G probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.152 -0.904 -4.056 2 236 20 20 6q21 55 D 1.00 171 0.000 E B -4 0.07 -0.42 ? ? ? ? ? ? ? 1 2 0 -54 PF00071.17 3.375 ? 67.72 +P01112 55 I N ? P01112 55 I N T A probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.270 -0.904 -4.174 2 236 20 20 6q21 55 D 1.00 171 0.000 E B -53 1.09 -0.42 ? ? ? ? ? ? ? 1 1 0 -53 PF00071.17 0.937 ? 67.72 +P01112 55 I P ? P01112 55 I P ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.252 -0.904 -4.156 2 236 20 20 6q21 55 D 1.00 171 0.000 E B -55 1 -0.42 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 0.969 ? 67.72 +P01112 55 I Q ? P01112 55 I Q ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.472 -0.904 -4.376 2 236 20 20 6q21 55 D 1.00 171 0.000 E B -23 1.12 -0.42 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.108 ? 67.72 +P01112 55 I R ? P01112 55 I R ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.280 -0.904 -4.184 2 236 20 20 6q21 55 D 1.00 171 0.000 E B 6 1.68 -0.42 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.657 ? 67.72 +P01112 55 I S ? P01112 55 I S T G probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.758 -0.904 -3.662 2 236 20 20 6q21 55 D 1.00 171 0.000 E B -78 0.75 -0.42 ? ? ? ? ? ? ? 1 1 0 -53 PF00071.17 1.662 ? 67.72 +P01112 55 I T ? P01112 55 I T T C probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.569 -0.904 -3.473 2 236 20 20 6q21 55 D 1.00 171 0.000 E B -51 0.7 -0.42 ? ? ? ? ? ? ? 0 1 0 -53 PF00071.17 2.276 ? 67.72 +P01112 55 I V ? P01112 55 I V A G probably damaging alignment ? deleterious 0.977 0.0424 0.758 0.0704 NO NO ? +1.588 -0.904 -2.492 2 236 20 20 6q21 55 D 1.00 171 0.000 E B -27 0.04 -0.42 ? ? ? ? ? ? ? 0 0 2 -52 PF00071.17 6.490 ? 67.72 +P01112 55 I W ? P01112 55 I W ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +4.445 -0.904 -5.349 2 236 20 20 6q21 55 D 1.00 171 0.000 E B 60 0.01 -0.42 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 0.501 ? 67.72 +P01112 55 I Y ? P01112 55 I Y ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.085 -0.904 -3.989 2 236 20 20 6q21 55 D 1.00 171 0.000 E B 26 0.27 -0.42 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.513 ? 67.72 +P01112 56 L A ? P01112 56 L A ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.023 -1.103 -3.126 2 236 20 20 6q21 56 D 1.00 171 0.234 E B -79 0.55 -0.08 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 3.530 ? 53.97 +P01112 56 L C ? P01112 56 L C ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.637 -1.103 -4.740 2 236 20 20 6q21 56 D 1.00 171 0.234 E B -59 0.09 -0.08 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 0.948 ? 53.97 +P01112 56 L D ? P01112 56 L D ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.032 -1.103 -4.135 2 236 20 20 6q21 56 D 1.00 171 0.234 E B -56 1.3 -0.08 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.000 ? 53.97 +P01112 56 L E ? P01112 56 L E ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.778 -1.103 -3.881 2 236 20 20 6q21 56 D 1.00 171 0.234 E B -29 1.59 -0.08 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.455 ? 53.97 +P01112 56 L F ? P01112 56 L F ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.560 -1.103 -3.663 2 236 20 20 6q21 56 D 1.00 171 0.234 E B 23 0.03 -0.08 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 7.087 ? 53.97 +P01112 56 L G ? P01112 56 L G ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.696 -1.103 -3.799 2 236 20 20 6q21 56 D 1.00 171 0.234 E B -107 0.84 -0.08 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.395 ? 53.97 +P01112 56 L H ? P01112 56 L H ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.703 -1.103 -4.806 2 236 20 20 6q21 56 D 1.00 171 0.234 E B -14 0.72 -0.08 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.543 ? 53.97 +P01112 56 L I ? P01112 56 L I ? ? probably damaging alignment ? deleterious 0.997 0.0167 0.409 0.0357 NO NO ? +1.873 -1.103 -2.976 2 236 20 20 6q21 56 D 1.00 171 0.234 E B 0 0.07 -0.08 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 8.340 ? 53.97 +P01112 56 L K ? P01112 56 L K ? ? probably damaging alignment ? deleterious 0.999 0.00574 0.136 0.0192 NO NO ? +2.642 -1.103 -3.745 2 236 20 20 6q21 56 D 1.00 171 0.234 E B 1 2.89 -0.08 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.670 ? 53.97 +P01112 56 L M ? P01112 56 L M C A probably damaging alignment ? deleterious 0.996 0.0222 0.545 0.0439 NO NO ? +1.822 -1.103 -2.925 2 236 20 20 6q21 56 D 1.00 171 0.234 E B -4 0 -0.08 ? ? ? ? ? ? ? 1 0 0 -55 PF00071.17 7.284 7.284 53.97 +P01112 56 L N ? P01112 56 L N ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.062 -1.103 -4.165 2 236 20 20 6q21 56 D 1.00 171 0.234 E B -53 1.16 -0.08 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.171 ? 53.97 +P01112 56 L P ? P01112 56 L P T C probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.013 -1.103 -4.116 2 236 20 20 6q21 56 D 1.00 171 0.234 E B -55 1.07 -0.08 ? ? ? ? ? ? ? 0 1 2 -56 PF00071.17 0.867 ? 53.97 +P01112 56 L Q ? P01112 56 L Q T A probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.038 -1.103 -4.141 2 236 20 20 6q21 56 D 1.00 171 0.234 E B -23 1.19 -0.08 ? ? ? ? ? ? ? 1 1 0 -56 PF00071.17 1.332 ? 53.97 +P01112 56 L R ? P01112 56 L R T G probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.937 -1.103 -4.040 2 236 20 20 6q21 56 D 1.00 171 0.234 E B 6 1.75 -0.08 ? ? ? ? ? ? ? 1 1 2 -56 PF00071.17 1.549 ? 53.97 +P01112 56 L S ? P01112 56 L S ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.571 -1.103 -3.674 2 236 20 20 6q21 56 D 1.00 171 0.234 E B -78 0.82 -0.08 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.722 ? 53.97 +P01112 56 L T ? P01112 56 L T ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.367 -1.103 -3.470 2 236 20 20 6q21 56 D 1.00 171 0.234 E B -51 0.77 -0.08 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.536 ? 53.97 +P01112 56 L V ? P01112 56 L V C G possibly damaging alignment ? deleterious 0.848 0.0674 0.834 0.0988 NO NO ? +0.825 -1.103 -1.928 2 236 20 20 6q21 56 D 1.00 171 0.234 E B -27 0.11 -0.08 ? ? ? ? ? ? ? 1 0 2 -55 PF00071.17 13.675 13.675 53.97 +P01112 56 L W ? P01112 56 L W ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.980 -1.103 -5.083 2 236 20 20 6q21 56 D 1.00 171 0.234 E B 60 0.08 -0.08 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.484 ? 53.97 +P01112 56 L Y ? P01112 56 L Y ? ? probably damaging alignment ? deleterious 0.98 0.0405 0.753 0.0679 NO NO ? +1.727 -1.103 -2.830 2 236 20 20 6q21 56 D 1.00 171 0.234 E B 26 0.34 -0.08 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 17.129 17.129 53.97 +P01112 57 D A ? P01112 57 D A A C probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.309 -0.981 -3.290 2 237 20 20 6q21 57 D 1.00 171 0.000 E B -23 0.75 -0.36 ? 1 4.961 ? ? ? ? 1 1 0 -59 PF00071.17 5.520 ? 71.43 +P01112 57 D C ? P01112 57 D C ? ? probably damaging alignment ? deleterious 0.997 0.0167 0.409 0.0357 NO NO ? +2.175 -0.981 -3.156 2 237 20 20 6q21 57 D 1.00 171 0.000 E B -3 1.21 -0.36 ? 1 4.961 ? ? ? ? ? ? ? ? PF00071.17 31.453 31.453 71.43 +P01112 57 D E ? P01112 57 D E T G probably damaging alignment ? deleterious 0.996 0.0222 0.545 0.0439 NO NO ? +2.091 -0.981 -3.072 2 237 20 20 6q21 57 D 1.00 171 0.000 E B 27 0.29 -0.36 ? 1 4.961 ? ? ? ? 1 2 0 -60 PF00071.17 3.366 ? 71.43 +P01112 57 D F ? P01112 57 D F ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.320 -0.981 -4.301 2 237 20 20 6q21 57 D 1.00 171 0.000 E B 79 1.33 -0.36 ? 1 4.961 ? ? ? ? ? ? ? ? PF00071.17 2.524 ? 71.43 +P01112 57 D G ? P01112 57 D G A G probably damaging alignment ? deleterious 0.995 0.0277 0.681 0.0521 NO NO ? +1.562 -0.981 -2.543 2 237 20 20 6q21 57 D 1.00 171 0.000 E B -51 0.46 -0.36 ? 1 4.961 ? ? ? ? 0 1 0 -59 PF00071.17 35.879 35.879 71.43 +P01112 57 D H ? P01112 57 D H G C probably damaging alignment ? deleterious 0.996 0.0222 0.545 0.0439 NO NO ? +2.102 -0.981 -3.083 2 237 20 20 6q21 57 D 1.00 171 0.000 E B 42 0.58 -0.36 ? 1 4.961 ? ? ? ? 1 0 0 -58 PF00071.17 22.853 22.853 71.43 +P01112 57 D I ? P01112 57 D I ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.918 -0.981 -3.899 2 237 20 20 6q21 57 D 1.00 171 0.000 E B 56 1.23 -0.36 ? 1 4.961 ? ? ? ? ? ? ? ? PF00071.17 11.728 ? 71.43 +P01112 57 D K ? P01112 57 D K ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.649 -0.981 -3.630 2 237 20 20 6q21 57 D 1.00 171 0.000 E B 57 1.59 -0.36 ? 1 4.961 ? ? ? ? ? ? ? ? PF00071.17 2.924 ? 71.43 +P01112 57 D L ? P01112 57 D L ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.711 -0.981 -3.692 2 237 20 20 6q21 57 D 1.00 171 0.000 E B 56 1.3 -0.36 ? 1 4.961 ? ? ? ? ? ? ? ? PF00071.17 9.285 ? 71.43 +P01112 57 D M ? P01112 57 D M ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.898 -0.981 -4.879 2 237 20 20 6q21 57 D 1.00 171 0.000 E B 52 1.3 -0.36 ? 1 4.961 ? ? ? ? ? ? ? ? PF00071.17 2.265 ? 71.43 +P01112 57 D N ? P01112 57 D N G A probably damaging alignment ? deleterious 0.999 0.00574 0.136 0.0192 NO NO ? +2.467 -0.981 -3.448 2 237 20 20 6q21 57 D 1.00 171 0.000 E B 3 0.14 -0.36 ? 1 4.961 ? ? ? ? 0 0 0 -58 PF00071.17 3.522 ? 71.43 +P01112 57 D P ? P01112 57 D P ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.863 -0.981 -3.844 2 237 20 20 6q21 57 D 1.00 171 0.000 E B 1 0.23 -0.36 ? 1 4.961 ? ? ? ? ? ? ? ? PF00071.17 1.295 ? 71.43 +P01112 57 D Q ? P01112 57 D Q ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.904 -0.981 -3.885 2 237 20 20 6q21 57 D 1.00 171 0.000 E B 33 0.11 -0.36 ? 1 4.961 ? ? ? ? ? ? ? ? PF00071.17 2.583 ? 71.43 +P01112 57 D R ? P01112 57 D R ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.051 -0.981 -4.032 2 237 20 20 6q21 57 D 1.00 171 0.000 E B 62 0.45 -0.36 ? 1 4.961 ? ? ? ? ? ? ? ? PF00071.17 3.055 ? 71.43 +P01112 57 D S ? P01112 57 D S ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.352 -0.981 -3.333 2 237 20 20 6q21 57 D 1.00 171 0.000 E B -22 0.48 -0.36 ? 1 4.961 ? ? ? ? ? ? ? ? PF00071.17 3.639 ? 71.43 +P01112 57 D T ? P01112 57 D T ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.564 -0.981 -3.545 2 237 20 20 6q21 57 D 1.00 171 0.000 E B 5 0.53 -0.36 ? 1 4.961 ? ? ? ? ? ? ? ? PF00071.17 3.566 ? 71.43 +P01112 57 D V ? P01112 57 D V A T probably damaging structure 1.1.1 deleterious 0.998 0.0112 0.273 0.0274 NO NO ? +1.849 -0.981 -2.830 2 237 20 20 6q21 57 D 1.00 171 0.000 E B 29 1.19 -0.36 ? 1 4.961 ? ? ? ? 1 1 0 -59 PF00071.17 19.231 19.231 71.43 +P01112 57 D W ? P01112 57 D W ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +4.537 -0.981 -5.518 2 237 20 20 6q21 57 D 1.00 171 0.000 E B 116 1.22 -0.36 ? 1 4.961 ? ? ? ? ? ? ? ? PF00071.17 0.387 ? 71.43 +P01112 57 D Y ? P01112 57 D Y G T probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.315 -0.981 -4.296 2 237 20 20 6q21 57 D 1.00 171 0.000 E B 82 0.96 -0.36 ? 1 4.961 ? ? ? ? 1 0 0 -58 PF00071.17 3.746 ? 71.43 +P01112 58 T A ? P01112 58 T A A G probably damaging alignment ? deleterious 0.997 0.0167 0.409 0.0357 NO NO ? +1.936 -0.975 -2.911 2 237 20 20 6q21 58 D 1.00 171 0.007 . B -28 0.22 -0.53 ? ? ? ? ? ? ? 0 0 0 -61 PF00071.17 7.399 ? 70.37 +P01112 58 T C ? P01112 58 T C ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.758 -0.975 -4.733 2 237 20 20 6q21 58 D 1.00 171 0.007 . B -8 0.68 -0.53 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.235 ? 70.37 +P01112 58 T D ? P01112 58 T D ? ? probably damaging alignment ? deleterious 0.999 0.00574 0.136 0.0192 NO NO ? +2.518 -0.975 -3.493 2 237 20 20 6q21 58 D 1.00 171 0.007 . B -5 0.53 -0.53 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 3.318 ? 70.37 +P01112 58 T E ? P01112 58 T E ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.466 -0.975 -3.441 2 237 20 20 6q21 58 D 1.00 171 0.007 . B 22 0.82 -0.53 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 3.669 ? 70.37 +P01112 58 T F ? P01112 58 T F ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.128 -0.975 -4.103 2 237 20 20 6q21 58 D 1.00 171 0.007 . B 74 0.8 -0.53 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.176 ? 70.37 +P01112 58 T G ? P01112 58 T G ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.364 -0.975 -3.339 2 237 20 20 6q21 58 D 1.00 171 0.007 . B -56 0.07 -0.53 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 4.537 ? 70.37 +P01112 58 T H ? P01112 58 T H ? ? probably damaging alignment ? deleterious 0.974 0.0438 0.763 0.0722 NO NO ? +1.984 -0.975 -2.959 2 237 20 20 6q21 58 D 1.00 171 0.007 . B 37 0.05 -0.53 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 24.913 24.913 70.37 +P01112 58 T I ? P01112 58 T I C T probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.712 -0.975 -3.687 2 237 20 20 6q21 58 D 1.00 171 0.007 . B 51 0.7 -0.53 ? ? ? ? ? ? ? 0 1 0 -62 PF00071.17 2.038 ? 70.37 +P01112 58 T K ? P01112 58 T K ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.506 -0.975 -3.481 2 237 20 20 6q21 58 D 1.00 171 0.007 . B 52 2.12 -0.53 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 3.670 ? 70.37 +P01112 58 T L ? P01112 58 T L ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.285 -0.975 -3.260 2 237 20 20 6q21 58 D 1.00 171 0.007 . B 51 0.77 -0.53 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.873 ? 70.37 +P01112 58 T M ? P01112 58 T M ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.585 -0.975 -4.560 2 237 20 20 6q21 58 D 1.00 171 0.007 . B 47 0.77 -0.53 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.027 ? 70.37 +P01112 58 T N ? P01112 58 T N C A probably damaging alignment ? deleterious 0.999 0.00574 0.136 0.0192 NO NO ? +2.474 -0.975 -3.449 2 237 20 20 6q21 58 D 1.00 171 0.007 . B -2 0.39 -0.53 ? ? ? ? ? ? ? 1 1 0 -62 PF00071.17 3.839 ? 70.37 +P01112 58 T P ? P01112 58 T P A C probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.760 -0.975 -3.735 2 237 20 20 6q21 58 D 1.00 171 0.007 . B -4 0.3 -0.53 ? ? ? ? ? ? ? 1 0 0 -61 PF00071.17 1.972 ? 70.37 +P01112 58 T Q ? P01112 58 T Q ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.925 -0.975 -3.900 2 237 20 20 6q21 58 D 1.00 171 0.007 . B 28 0.42 -0.53 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.816 ? 70.37 +P01112 58 T R ? P01112 58 T R ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.769 -0.975 -3.744 2 237 20 20 6q21 58 D 1.00 171 0.007 . B 57 0.98 -0.53 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 3.331 ? 70.37 +P01112 58 T S ? P01112 58 T S C G possibly damaging alignment ? deleterious 0.859 0.0667 0.831 0.0981 NO NO ? +1.244 -0.975 -2.219 2 237 20 20 6q21 58 D 1.00 171 0.007 . B -27 0.05 -0.53 ? ? ? ? ? ? ? 1 1 0 -62 PF00071.17 14.894 14.894 70.37 +P01112 58 T V ? P01112 58 T V ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.270 -0.975 -3.245 2 237 20 20 6q21 58 D 1.00 171 0.007 . B 24 0.66 -0.53 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.791 ? 70.37 +P01112 58 T W ? P01112 58 T W ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +4.213 -0.975 -5.188 2 237 20 20 6q21 58 D 1.00 171 0.007 . B 111 0.69 -0.53 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 0.407 ? 70.37 +P01112 58 T Y ? P01112 58 T Y ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.115 -0.975 -4.090 2 237 20 20 6q21 58 D 1.00 171 0.007 . B 77 0.43 -0.53 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 4.084 ? 70.37 +P01112 59 A C ? P01112 59 A C ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.478 -1.232 -4.710 2 237 20 20 6q21 59 D 1.00 171 0.126 . B 20 0.46 0.63 ? 1 5.158 ? ? ? ? ? ? ? ? PF00071.17 1.509 ? 82.54 +P01112 59 A D ? P01112 59 A D C A probably damaging alignment ? deleterious 0.986 0.0368 0.736 0.0634 NO NO ? +2.461 -1.232 -3.693 2 237 20 20 6q21 59 D 1.00 171 0.126 . B 23 0.75 0.63 ? 1 5.158 ? ? ? ? 1 1 0 -65 PF00071.17 3.499 ? 82.54 +P01112 59 A E ? P01112 59 A E ? ? probably damaging alignment ? deleterious 0.992 0.0314 0.704 0.0568 NO NO ? +2.317 -1.232 -3.549 2 237 20 20 6q21 59 D 1.00 171 0.126 . B 50 1.04 0.63 ? 1 5.158 ? ? ? ? ? ? ? ? PF00071.17 3.687 ? 82.54 +P01112 59 A F ? P01112 59 A F ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.004 -1.232 -4.236 2 237 20 20 6q21 59 D 1.00 171 0.126 . B 102 0.58 0.63 ? 1 5.158 ? ? ? ? ? ? ? ? PF00071.17 1.885 ? 82.54 +P01112 59 A G ? P01112 59 A G C G benign alignment ? neutral 0.031 0.181 0.947 0.205 NO NO ? +1.060 -1.232 -2.292 2 237 20 20 6q21 59 D 1.00 171 0.126 . B -28 0.29 0.63 ? 1 5.158 ? ? ? ? 1 1 0 -65 PF00071.17 36.418 36.418 82.54 +P01112 59 A H ? P01112 59 A H ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.516 -1.232 -4.748 2 237 20 20 6q21 59 D 1.00 171 0.126 . B 65 0.17 0.63 ? 1 5.158 ? ? ? ? ? ? ? ? PF00071.17 1.379 ? 82.54 +P01112 59 A I ? P01112 59 A I ? ? probably damaging alignment ? deleterious 0.997 0.0167 0.409 0.0357 NO NO ? +2.565 -1.232 -3.797 2 237 20 20 6q21 59 D 1.00 171 0.126 . B 79 0.48 0.63 ? 1 5.158 ? ? ? ? ? ? ? ? PF00071.17 4.372 ? 82.54 +P01112 59 A K ? P01112 59 A K ? ? probably damaging alignment ? deleterious 0.994 0.0289 0.689 0.0537 NO NO ? +2.286 -1.232 -3.518 2 237 20 20 6q21 59 D 1.00 171 0.126 . B 80 2.34 0.63 ? 1 5.158 ? ? ? ? ? ? ? ? PF00071.17 5.176 ? 82.54 +P01112 59 A L ? P01112 59 A L ? ? probably damaging alignment ? deleterious 0.994 0.0289 0.689 0.0537 NO NO ? +2.126 -1.232 -3.358 2 237 20 20 6q21 59 D 1.00 171 0.126 . B 79 0.55 0.63 ? 1 5.158 ? ? ? ? ? ? ? ? PF00071.17 5.391 ? 82.54 +P01112 59 A M ? P01112 59 A M ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.420 -1.232 -4.652 2 237 20 20 6q21 59 D 1.00 171 0.126 . B 75 0.55 0.63 ? 1 5.158 ? ? ? ? ? ? ? ? PF00071.17 1.637 ? 82.54 +P01112 59 A N ? P01112 59 A N ? ? possibly damaging alignment ? deleterious 0.914 0.0603 0.813 0.0913 NO NO ? +2.515 -1.232 -3.747 2 237 20 20 6q21 59 D 1.00 171 0.126 . B 26 0.61 0.63 ? 1 5.158 ? ? ? ? ? ? ? ? PF00071.17 3.927 ? 82.54 +P01112 59 A P ? P01112 59 A P G C probably damaging alignment ? deleterious 0.997 0.0167 0.409 0.0357 NO NO ? +2.592 -1.232 -3.824 2 237 20 20 6q21 59 D 1.00 171 0.126 . B 24 0.52 0.63 ? 1 5.158 ? ? ? ? 1 0 1 -64 PF00071.17 2.191 ? 82.54 +P01112 59 A Q ? P01112 59 A Q ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.755 -1.232 -3.987 2 237 20 20 6q21 59 D 1.00 171 0.126 . B 56 0.64 0.63 ? 1 5.158 ? ? ? ? ? ? ? ? PF00071.17 2.363 ? 82.54 +P01112 59 A R ? P01112 59 A R ? ? possibly damaging alignment ? deleterious 0.944 0.0544 0.797 0.0847 NO NO ? +1.677 -1.232 -2.909 2 237 20 20 6q21 59 D 1.00 171 0.126 . B 85 1.2 0.63 ? 1 5.158 ? ? ? ? ? ? ? ? PF00071.17 14.745 14.745 82.54 +P01112 59 A S ? P01112 59 A S G T benign alignment ? neutral 0.207 0.124 0.915 0.155 NO NO ? +1.145 -1.232 -2.377 2 237 20 20 6q21 59 D 1.00 171 0.126 . B 1 0.27 0.63 ? 1 5.158 ? ? ? ? 1 0 1 -64 PF00071.17 15.709 15.709 82.54 +P01112 59 A T ? P01112 59 A T G A benign alignment ? neutral 0.344 0.11 0.9 0.142 NO NO ? +0.722 -1.232 -1.954 2 237 20 20 6q21 59 D 1.00 171 0.126 . B 28 0.22 0.63 ? 1 5.158 ? ? ? ? 0 0 1 -64 PF00071.17 20.298 20.298 82.54 +P01112 59 A V ? P01112 59 A V C T probably damaging alignment ? deleterious 0.98 0.0405 0.753 0.0679 NO NO ? +2.113 -1.232 -3.345 2 237 20 20 6q21 59 D 1.00 171 0.126 . B 52 0.44 0.63 ? 1 5.158 ? ? ? ? 0 1 0 -65 PF00071.17 5.904 ? 82.54 +P01112 59 A W ? P01112 59 A W ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +4.144 -1.232 -5.376 2 237 20 20 6q21 59 D 1.00 171 0.126 . B 139 0.47 0.63 ? 1 5.158 ? ? ? ? ? ? ? ? PF00071.17 0.463 ? 82.54 +P01112 59 A Y ? P01112 59 A Y ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.085 -1.232 -4.317 2 237 20 20 6q21 59 D 1.00 171 0.126 . B 105 0.21 0.63 ? 1 5.158 ? ? ? ? ? ? ? ? PF00071.17 1.527 ? 82.54 +P01112 60 G A ? P01112 60 G A G C probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.154 -0.749 -2.903 2 237 20 20 6q21 60 D 1.00 171 0.046 . B 28 0.29 1.73 ? ? ? ? ? ? ? 1 1 0 -68 PF00071.17 4.914 ? 44.97 +P01112 60 G C ? P01112 60 G C G T probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.293 -0.749 -3.042 2 237 20 20 6q21 60 D 1.00 171 0.046 . B 48 0.75 1.73 ? ? ? ? ? ? ? 1 0 1 -67 PF00071.17 21.736 21.736 44.97 +P01112 60 G D ? P01112 60 G D G A probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.803 -0.749 -3.552 2 237 20 20 6q21 60 D 1.00 171 0.046 . B 51 0.46 1.73 ? ? ? ? ? ? ? 0 1 0 -68 PF00071.17 2.203 ? 44.97 +P01112 60 G E ? P01112 60 G E ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.970 -0.749 -3.719 2 237 20 20 6q21 60 D 1.00 171 0.046 . B 78 0.75 1.73 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.321 ? 44.97 +P01112 60 G F ? P01112 60 G F ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.571 -0.749 -4.320 2 237 20 20 6q21 60 D 1.00 171 0.046 . B 130 0.87 1.73 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 0.938 ? 44.97 +P01112 60 G H ? P01112 60 G H ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.999 -0.749 -4.748 2 237 20 20 6q21 60 D 1.00 171 0.046 . B 93 0.12 1.73 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 0.869 ? 44.97 +P01112 60 G I ? P01112 60 G I ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.428 -0.749 -4.177 2 237 20 20 6q21 60 D 1.00 171 0.046 . B 107 0.77 1.73 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.996 ? 44.97 +P01112 60 G K ? P01112 60 G K ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.973 -0.749 -3.722 2 237 20 20 6q21 60 D 1.00 171 0.046 . B 108 2.05 1.73 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.437 ? 44.97 +P01112 60 G L ? P01112 60 G L ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.001 -0.749 -3.750 2 237 20 20 6q21 60 D 1.00 171 0.046 . B 107 0.84 1.73 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.857 ? 44.97 +P01112 60 G M ? P01112 60 G M ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +4.155 -0.749 -4.904 2 237 20 20 6q21 60 D 1.00 171 0.046 . B 103 0.84 1.73 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 0.687 ? 44.97 +P01112 60 G N ? P01112 60 G N ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.794 -0.749 -3.543 2 237 20 20 6q21 60 D 1.00 171 0.046 . B 54 0.32 1.73 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.473 ? 44.97 +P01112 60 G P ? P01112 60 G P ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.199 -0.749 -3.948 2 237 20 20 6q21 60 D 1.00 171 0.046 . B 52 0.23 1.73 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.309 ? 44.97 +P01112 60 G Q ? P01112 60 G Q ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.415 -0.749 -4.164 2 237 20 20 6q21 60 D 1.00 171 0.046 . B 84 0.35 1.73 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.488 ? 44.97 +P01112 60 G R ? P01112 60 G R G C probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.252 -0.749 -4.001 2 237 20 20 6q21 60 D 1.00 171 0.046 . B 113 0.91 1.73 ? ? ? ? ? ? ? 1 0 3 -67 PF00071.17 1.781 ? 44.97 +P01112 60 G S ? P01112 60 G S G A probably damaging alignment ? deleterious 0.999 0.00574 0.136 0.0192 NO NO ? +1.798 -0.749 -2.547 2 237 20 20 6q21 60 D 1.00 171 0.046 . B 29 0.02 1.73 ? ? ? ? ? ? ? 0 0 1 -67 PF00071.17 9.891 9.891 44.97 +P01112 60 G T ? P01112 60 G T ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.865 -0.749 -3.614 2 237 20 20 6q21 60 D 1.00 171 0.046 . B 56 0.07 1.73 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 3.694 ? 44.97 +P01112 60 G V ? P01112 60 G V G T probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.005 -0.749 -3.754 2 237 20 20 6q21 60 D 1.00 171 0.046 . B 80 0.73 1.73 ? ? ? ? ? ? ? 1 1 0 -68 PF00071.17 2.479 ? 44.97 +P01112 60 G W ? P01112 60 G W ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +4.440 -0.749 -5.189 2 237 20 20 6q21 60 D 1.00 171 0.046 . B 167 0.76 1.73 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 0.264 ? 44.97 +P01112 60 G Y ? P01112 60 G Y ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.666 -0.749 -4.415 2 237 20 20 6q21 60 D 1.00 171 0.046 . B 133 0.5 1.73 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 0.809 ? 44.97 +P01112 61 Q A ? P01112 61 Q A ? ? possibly damaging alignment ? deleterious 0.54 0.095 0.88 0.128 NO NO ? +1.673 -1.542 -3.215 2 237 20 20 6q21 61 D 1.00 171 0.409 S a -56 0.64 1.76 ? 1 3.843 ? ? ? ? ? ? ? ? PF00071.17 5.434 ? 85.19 +P01112 61 Q C ? P01112 61 Q C ? ? probably damaging alignment ? deleterious 0.983 0.0387 0.745 0.0657 NO NO ? +3.579 -1.542 -5.121 2 237 20 20 6q21 61 D 1.00 171 0.409 S a -36 1.1 1.76 ? 1 3.843 ? ? ? ? ? ? ? ? PF00071.17 0.929 ? 85.19 +P01112 61 Q D ? P01112 61 Q D ? ? possibly damaging alignment ? deleterious 0.711 0.0814 0.858 0.114 NO NO ? +1.990 -1.542 -3.532 2 237 20 20 6q21 61 D 1.00 171 0.409 S a -33 0.11 1.76 ? 1 3.843 ? ? ? ? ? ? ? ? PF00071.17 3.748 ? 85.19 +P01112 61 Q E ? P01112 61 Q E C G benign alignment ? neutral 0.268 0.117 0.909 0.148 NO NO ? +1.705 -1.542 -3.247 2 237 20 20 6q21 61 D 1.00 171 0.409 S a -6 0.4 1.76 ? 1 3.843 ? ? ? ? 1 0 2 -70 PF00071.17 5.902 ? 85.19 +P01112 61 Q F ? P01112 61 Q F ? ? possibly damaging alignment ? deleterious 0.945 0.054 0.796 0.0842 NO NO ? +2.792 -1.542 -4.334 2 237 20 20 6q21 61 D 1.00 171 0.409 S a 46 1.22 1.76 ? 1 3.843 ? ? ? ? ? ? ? ? PF00071.17 2.634 ? 85.19 +P01112 61 Q G ? P01112 61 Q G ? ? possibly damaging alignment ? deleterious 0.891 0.0637 0.821 0.0952 NO NO ? +1.937 -1.542 -3.479 2 237 20 20 6q21 61 D 1.00 171 0.409 S a -84 0.35 1.76 ? 1 3.843 ? ? ? ? ? ? ? ? PF00071.17 3.627 ? 85.19 +P01112 61 Q H ? P01112 61 Q H G C benign alignment ? neutral 0.028 0.185 0.948 0.209 NO NO ? +1.691 -1.542 -3.233 2 237 20 20 6q21 61 D 1.00 171 0.409 S a 9 0.47 1.76 ? 1 3.843 ? ? ? ? 1 2 2 -72 PF00071.17 30.158 30.158 85.19 +P01112 61 Q I ? P01112 61 Q I ? ? benign alignment ? neutral 0.062 0.16 0.937 0.188 NO NO ? +1.286 -1.542 -2.828 2 237 20 20 6q21 61 D 1.00 171 0.409 S a 23 1.12 1.76 ? 1 3.843 ? ? ? ? ? ? ? ? PF00071.17 13.361 13.361 85.19 +P01112 61 Q K rs28933406 P01112 61 Q K C A benign alignment ? neutral 0.012 0.219 0.958 0.236 NO NO ? +1.216 -1.542 -2.758 2 237 20 20 6q21 61 D 1.00 171 0.409 S a 24 1.7 1.76 ? 1 3.843 ? ? ? ? 1 0 0 -70 PF00071.17 23.016 23.016 85.19 +P01112 61 Q L ? P01112 61 Q L A T possibly damaging alignment ? deleterious 0.552 0.0945 0.878 0.127 NO NO ? +1.893 -1.542 -3.435 2 237 20 20 6q21 61 D 1.00 171 0.409 S a 23 1.19 1.76 ? 1 3.843 ? ? ? ? 1 1 0 -71 PF00071.17 8.247 ? 85.19 +P01112 61 Q M ? P01112 61 Q M ? ? probably damaging alignment ? deleterious 0.962 0.0478 0.779 0.0767 NO NO ? +3.019 -1.542 -4.561 2 237 20 20 6q21 61 D 1.00 171 0.409 S a 19 1.19 1.76 ? 1 3.843 ? ? ? ? ? ? ? ? PF00071.17 1.817 ? 85.19 +P01112 61 Q N ? P01112 61 Q N ? ? benign alignment ? neutral 0.048 0.167 0.941 0.194 NO NO ? +1.117 -1.542 -2.659 2 237 20 20 6q21 61 D 1.00 171 0.409 S a -30 0.0299999999999999 1.76 ? 1 3.843 ? ? ? ? ? ? ? ? PF00071.17 14.244 14.244 85.19 +P01112 61 Q P ? P01112 61 Q P A C benign alignment ? neutral 0.021 0.196 0.951 0.219 NO NO ? +1.427 -1.542 -2.969 2 237 20 20 6q21 61 D 1.00 171 0.409 S a -32 0.12 1.76 ? 1 3.843 ? ? ? ? 1 1 2 -71 PF00071.17 34.815 34.815 85.19 +P01112 61 Q R ? P01112 61 Q R A G benign alignment ? neutral 0.008 0.239 0.963 0.252 NO NO ? +1.367 -1.542 -2.909 2 237 20 20 6q21 61 D 1.00 171 0.409 S a 29 0.56 1.76 ? 1 3.843 ? ? ? ? 0 1 2 -71 PF00071.17 24.574 24.574 85.19 +P01112 61 Q S ? P01112 61 Q S ? ? benign alignment ? neutral 0.326 0.111 0.902 0.143 NO NO ? +1.023 -1.542 -2.565 2 237 20 20 6q21 61 D 1.00 171 0.409 S a -55 0.37 1.76 ? 1 3.843 ? ? ? ? ? ? ? ? PF00071.17 10.938 10.938 85.19 +P01112 61 Q T ? P01112 61 Q T ? ? benign alignment ? neutral 0.008 0.239 0.963 0.252 NO NO ? +0.888 -1.542 -2.430 2 237 20 20 6q21 61 D 1.00 171 0.409 S a -28 0.42 1.76 ? 1 3.843 ? ? ? ? ? ? ? ? PF00071.17 12.491 12.491 85.19 +P01112 61 Q V ? P01112 61 Q V ? ? benign alignment ? neutral 0.329 0.111 0.902 0.143 NO NO ? +1.987 -1.542 -3.529 2 237 20 20 6q21 61 D 1.00 171 0.409 S a -4 1.08 1.76 ? 1 3.843 ? ? ? ? ? ? ? ? PF00071.17 8.674 ? 85.19 +P01112 61 Q W ? P01112 61 Q W ? ? probably damaging alignment ? deleterious 0.996 0.0222 0.545 0.0439 NO NO ? +3.856 -1.542 -5.398 2 237 20 20 6q21 61 D 1.00 171 0.409 S a 83 1.11 1.76 ? 1 3.843 ? ? ? ? ? ? ? ? PF00071.17 0.493 ? 85.19 +P01112 61 Q Y ? P01112 61 Q Y ? ? possibly damaging alignment ? deleterious 0.696 0.0827 0.86 0.115 NO NO ? +2.628 -1.542 -4.170 2 237 20 20 6q21 61 D 1.00 171 0.409 S a 49 0.85 1.76 ? 1 3.843 ? ? ? ? ? ? ? ? PF00071.17 4.944 ? 85.19 +P01112 62 E A ? P01112 62 E A A C possibly damaging alignment ? neutral 0.46 0.0994 0.888 0.132 NO NO ? +1.411 -1.124 -2.535 2 235 20 20 6q21 62 D 1.00 171 0.872 S b -50 1.04 2.28 ? ? ? ? ? ? ? 1 1 2 -74 PF00071.17 14.100 14.100 70.37 +P01112 62 E C ? P01112 62 E C ? ? probably damaging alignment ? deleterious 0.998 0.0112 0.273 0.0274 NO NO ? +4.122 -1.124 -5.246 2 235 20 20 6q21 62 D 1.00 171 0.872 S b -30 1.5 2.28 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.043 ? 70.37 +P01112 62 E D ? P01112 62 E D G C benign alignment ? neutral 0.01 0.226 0.96 0.242 NO NO ? +1.149 -1.124 -2.273 2 235 20 20 6q21 62 D 1.00 171 0.872 S b -27 0.29 2.28 ? ? ? ? ? ? ? 1 2 2 -75 PF00071.17 22.670 22.670 70.37 +P01112 62 E F ? P01112 62 E F ? ? probably damaging alignment ? deleterious 0.999 0.00574 0.136 0.0192 NO NO ? +3.258 -1.124 -4.382 2 235 20 20 6q21 62 D 1.00 171 0.872 S b 52 1.62 2.28 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.137 ? 70.37 +P01112 62 E G ? P01112 62 E G A G benign alignment ? neutral 0.215 0.123 0.915 0.154 NO NO ? +1.194 -1.124 -2.318 2 235 20 20 6q21 62 D 1.00 171 0.872 S b -78 0.75 2.28 ? ? ? ? ? ? ? 0 1 0 -74 PF00071.17 35.879 35.879 70.37 +P01112 62 E H ? P01112 62 E H ? ? probably damaging alignment ? deleterious 0.999 0.00574 0.136 0.0192 NO NO ? +3.333 -1.124 -4.457 2 235 20 20 6q21 62 D 1.00 171 0.872 S b 15 0.87 2.28 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.340 ? 70.37 +P01112 62 E I ? P01112 62 E I ? ? probably damaging alignment ? deleterious 0.993 0.0301 0.696 0.0553 NO NO ? +2.976 -1.124 -4.100 2 235 20 20 6q21 62 D 1.00 171 0.872 S b 29 1.52 2.28 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.091 ? 70.37 +P01112 62 E K ? P01112 62 E K G A possibly damaging alignment ? deleterious 0.612 0.091 0.872 0.124 NO NO ? +1.470 -1.124 -2.594 2 235 20 20 6q21 62 D 1.00 171 0.872 S b 30 1.3 2.28 ? ? ? ? ? ? ? 0 0 0 -73 PF00071.17 18.178 18.178 70.37 +P01112 62 E L ? P01112 62 E L ? ? possibly damaging alignment ? deleterious 0.952 0.0518 0.789 0.0817 NO NO ? +2.552 -1.124 -3.676 2 235 20 20 6q21 62 D 1.00 171 0.872 S b 29 1.59 2.28 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.898 ? 70.37 +P01112 62 E M ? P01112 62 E M ? ? probably damaging alignment ? deleterious 0.988 0.0353 0.727 0.0617 NO NO ? +3.698 -1.124 -4.822 2 235 20 20 6q21 62 D 1.00 171 0.872 S b 25 1.59 2.28 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.025 ? 70.37 +P01112 62 E N ? P01112 62 E N ? ? possibly damaging alignment ? deleterious 0.903 0.0622 0.817 0.0936 NO NO ? +2.432 -1.124 -3.556 2 235 20 20 6q21 62 D 1.00 171 0.872 S b -24 0.43 2.28 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 3.964 ? 70.37 +P01112 62 E P ? P01112 62 E P ? ? possibly damaging alignment ? deleterious 0.857 0.0669 0.831 0.0983 NO NO ? +2.664 -1.124 -3.788 2 235 20 20 6q21 62 D 1.00 171 0.872 S b -26 0.52 2.28 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.779 ? 70.37 +P01112 62 E Q ? P01112 62 E Q G C probably damaging alignment ? deleterious 0.958 0.0492 0.783 0.0785 NO NO ? +2.392 -1.124 -3.516 2 235 20 20 6q21 62 D 1.00 171 0.872 S b 6 0.4 2.28 ? ? ? ? ? ? ? 1 0 0 -73 PF00071.17 3.494 ? 70.37 +P01112 62 E R ? P01112 62 E R ? ? possibly damaging alignment ? deleterious 0.955 0.0505 0.786 0.0801 NO NO ? +2.527 -1.124 -3.651 2 235 20 20 6q21 62 D 1.00 171 0.872 S b 35 0.16 2.28 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 7.033 ? 70.37 +P01112 62 E S ? P01112 62 E S ? ? probably damaging alignment ? deleterious 0.958 0.0492 0.783 0.0785 NO NO ? +2.127 -1.124 -3.251 2 235 20 20 6q21 62 D 1.00 171 0.872 S b -49 0.77 2.28 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 4.101 ? 70.37 +P01112 62 E T ? P01112 62 E T ? ? probably damaging alignment ? deleterious 0.969 0.045 0.77 0.0734 NO NO ? +2.411 -1.124 -3.535 2 235 20 20 6q21 62 D 1.00 171 0.872 S b -22 0.82 2.28 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.647 ? 70.37 +P01112 62 E V ? P01112 62 E V A T possibly damaging alignment ? deleterious 0.914 0.0603 0.813 0.0913 NO NO ? +2.517 -1.124 -3.641 2 235 20 20 6q21 62 D 1.00 171 0.872 S b 2 1.48 2.28 ? ? ? ? ? ? ? 1 1 0 -74 PF00071.17 3.324 ? 70.37 +P01112 62 E W ? P01112 62 E W ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +4.302 -1.124 -5.426 2 235 20 20 6q21 62 D 1.00 171 0.872 S b 89 1.51 2.28 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 0.387 ? 70.37 +P01112 62 E Y ? P01112 62 E Y ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.197 -1.124 -4.321 2 235 20 20 6q21 62 D 1.00 171 0.872 S b 55 1.25 2.28 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.127 ? 70.37 +P01112 63 E A ? P01112 63 E A A C possibly damaging alignment ? deleterious 0.641 0.0886 0.866 0.122 NO NO ? +1.086 -1.285 -2.371 2 237 20 20 6q21 63 D 1.00 171 0.332 . b -50 1.04 2.02 ? ? ? ? ? ? ? 1 1 2 -77 PF00071.17 13.334 13.334 70.37 +P01112 63 E C ? P01112 63 E C ? ? probably damaging alignment ? deleterious 0.999 0.00574 0.136 0.0192 NO NO ? +3.891 -1.285 -5.176 2 237 20 20 6q21 63 D 1.00 171 0.332 . b -30 1.5 2.02 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 0.986 ? 70.37 +P01112 63 E D ? P01112 63 E D G C benign alignment ? neutral 0.008 0.239 0.963 0.252 NO NO ? +0.747 -1.285 -2.032 2 237 20 20 6q21 63 D 1.00 171 0.332 . b -27 0.29 2.02 ? ? ? ? ? ? ? 1 2 0 -78 PF00071.17 25.608 25.608 70.37 +P01112 63 E F ? P01112 63 E F ? ? probably damaging alignment ? deleterious 0.998 0.0112 0.273 0.0274 NO NO ? +3.046 -1.285 -4.331 2 237 20 20 6q21 63 D 1.00 171 0.332 . b 52 1.62 2.02 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.969 ? 70.37 +P01112 63 E G ? P01112 63 E G A G benign alignment ? neutral 0.173 0.13 0.919 0.161 NO NO ? +0.890 -1.285 -2.175 2 237 20 20 6q21 63 D 1.00 171 0.332 . b -78 0.75 2.02 ? ? ? ? ? ? ? 0 1 0 -77 PF00071.17 35.879 35.879 70.37 +P01112 63 E H ? P01112 63 E H ? ? probably damaging alignment ? deleterious 0.999 0.00574 0.136 0.0192 NO NO ? +3.252 -1.285 -4.537 2 237 20 20 6q21 63 D 1.00 171 0.332 . b 15 0.87 2.02 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.148 ? 70.37 +P01112 63 E I ? P01112 63 E I ? ? possibly damaging alignment ? deleterious 0.833 0.0689 0.837 0.1 NO NO ? +1.710 -1.285 -2.995 2 237 20 20 6q21 63 D 1.00 171 0.332 . b 29 1.52 2.02 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 11.924 11.924 70.37 +P01112 63 E K ? P01112 63 E K G A probably damaging alignment ? deleterious 0.983 0.0387 0.745 0.0657 NO NO ? +2.096 -1.285 -3.381 2 237 20 20 6q21 63 D 1.00 171 0.332 . b 30 1.3 2.02 ? ? ? ? ? ? ? 0 0 0 -76 PF00071.17 2.943 ? 70.37 +P01112 63 E L ? P01112 63 E L ? ? possibly damaging alignment ? deleterious 0.946 0.0537 0.795 0.0839 NO NO ? +2.294 -1.285 -3.579 2 237 20 20 6q21 63 D 1.00 171 0.332 . b 29 1.59 2.02 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 7.360 ? 70.37 +P01112 63 E M ? P01112 63 E M ? ? probably damaging alignment ? deleterious 0.98 0.0405 0.753 0.0679 NO NO ? +3.520 -1.285 -4.805 2 237 20 20 6q21 63 D 1.00 171 0.332 . b 25 1.59 2.02 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.622 ? 70.37 +P01112 63 E N ? P01112 63 E N ? ? possibly damaging alignment ? deleterious 0.942 0.0552 0.798 0.0857 NO NO ? +2.323 -1.285 -3.608 2 237 20 20 6q21 63 D 1.00 171 0.332 . b -24 0.43 2.02 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 4.478 ? 70.37 +P01112 63 E P ? P01112 63 E P ? ? probably damaging alignment ? deleterious 0.97 0.0446 0.769 0.0728 NO NO ? +2.557 -1.285 -3.842 2 237 20 20 6q21 63 D 1.00 171 0.332 . b -26 0.52 2.02 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.489 ? 70.37 +P01112 63 E Q ? P01112 63 E Q G C probably damaging alignment ? deleterious 0.988 0.0353 0.727 0.0617 NO NO ? +2.358 -1.285 -3.643 2 237 20 20 6q21 63 D 1.00 171 0.332 . b 6 0.4 2.02 ? ? ? ? ? ? ? 1 0 0 -76 PF00071.17 1.984 ? 70.37 +P01112 63 E R ? P01112 63 E R ? ? probably damaging alignment ? deleterious 0.993 0.0301 0.696 0.0553 NO NO ? +2.519 -1.285 -3.804 2 237 20 20 6q21 63 D 1.00 171 0.332 . b 35 0.16 2.02 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.910 ? 70.37 +P01112 63 E S ? P01112 63 E S ? ? probably damaging alignment ? deleterious 0.976 0.043 0.76 0.0712 NO NO ? +2.005 -1.285 -3.290 2 237 20 20 6q21 63 D 1.00 171 0.332 . b -49 0.77 2.02 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 3.878 ? 70.37 +P01112 63 E T ? P01112 63 E T ? ? probably damaging alignment ? deleterious 0.991 0.0326 0.711 0.0584 NO NO ? +2.269 -1.285 -3.554 2 237 20 20 6q21 63 D 1.00 171 0.332 . b -22 0.82 2.02 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.306 ? 70.37 +P01112 63 E V ? P01112 63 E V A T possibly damaging alignment ? deleterious 0.904 0.0621 0.816 0.0934 NO NO ? +2.239 -1.285 -3.524 2 237 20 20 6q21 63 D 1.00 171 0.332 . b 2 1.48 2.02 ? ? ? ? ? ? ? 1 1 0 -77 PF00071.17 7.742 ? 70.37 +P01112 63 E W ? P01112 63 E W ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +4.168 -1.285 -5.453 2 237 20 20 6q21 63 D 1.00 171 0.332 . b 89 1.51 2.02 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 0.387 ? 70.37 +P01112 63 E Y ? P01112 63 E Y ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.056 -1.285 -4.341 2 237 20 20 6q21 63 D 1.00 171 0.332 . b 55 1.25 2.02 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 0.894 ? 70.37 +P01112 64 Y A ? P01112 64 Y A ? ? probably damaging alignment ? deleterious 0.998 0.0112 0.273 0.0274 NO NO ? +2.199 -1.116 -3.315 2 237 20 20 6q21 64 D 1.00 171 0.282 S b -105 0.21 2.40 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 4.891 ? 71.43 +P01112 64 Y C ? P01112 64 Y C A G probably damaging alignment ? deleterious 0.974 0.0438 0.763 0.0722 NO NO ? +1.981 -1.116 -3.097 2 237 20 20 6q21 64 D 1.00 171 0.282 S b -85 0.25 2.40 ? ? ? ? ? ? ? 0 1 0 -80 PF00071.17 34.521 34.521 71.43 +P01112 64 Y D ? P01112 64 Y D T G probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.903 -1.116 -4.019 2 237 20 20 6q21 64 D 1.00 171 0.282 S b -82 0.96 2.40 ? ? ? ? ? ? ? 1 0 0 -79 PF00071.17 1.270 ? 71.43 +P01112 64 Y E ? P01112 64 Y E ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.722 -1.116 -3.838 2 237 20 20 6q21 64 D 1.00 171 0.282 S b -55 1.25 2.40 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.639 ? 71.43 +P01112 64 Y F ? P01112 64 Y F A T benign alignment ? neutral 0.186 0.128 0.917 0.159 NO NO ? +0.911 -1.116 -2.027 2 237 20 20 6q21 64 D 1.00 171 0.282 S b -3 0.37 2.40 ? ? ? ? ? ? ? 1 1 0 -80 PF00071.17 21.822 21.822 71.43 +P01112 64 Y G ? P01112 64 Y G ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.568 -1.116 -3.684 2 237 20 20 6q21 64 D 1.00 171 0.282 S b -133 0.5 2.40 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.226 ? 71.43 +P01112 64 Y H ? P01112 64 Y H T C probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.000 -1.116 -4.116 2 237 20 20 6q21 64 D 1.00 171 0.282 S b -40 0.38 2.40 ? ? ? ? ? ? ? 0 0 0 -79 PF00071.17 0.968 ? 71.43 +P01112 64 Y I ? P01112 64 Y I ? ? probably damaging alignment ? deleterious 0.96 0.0483 0.781 0.0774 NO NO ? +2.388 -1.116 -3.504 2 237 20 20 6q21 64 D 1.00 171 0.282 S b -26 0.27 2.40 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 11.554 ? 71.43 +P01112 64 Y K ? P01112 64 Y K ? ? probably damaging alignment ? deleterious 0.997 0.0167 0.409 0.0357 NO NO ? +2.725 -1.116 -3.841 2 237 20 20 6q21 64 D 1.00 171 0.282 S b -25 2.55 2.40 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.868 ? 71.43 +P01112 64 Y L ? P01112 64 Y L ? ? probably damaging alignment ? deleterious 0.96 0.0483 0.781 0.0774 NO NO ? +2.025 -1.116 -3.141 2 237 20 20 6q21 64 D 1.00 171 0.282 S b -26 0.34 2.40 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 9.147 ? 71.43 +P01112 64 Y M ? P01112 64 Y M ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.371 -1.116 -4.487 2 237 20 20 6q21 64 D 1.00 171 0.282 S b -30 0.34 2.40 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.232 ? 71.43 +P01112 64 Y N ? P01112 64 Y N T A probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.959 -1.116 -4.075 2 237 20 20 6q21 64 D 1.00 171 0.282 S b -79 0.82 2.40 ? ? ? ? ? ? ? 1 0 0 -79 PF00071.17 1.269 ? 71.43 +P01112 64 Y P ? P01112 64 Y P ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.110 -1.116 -4.226 2 237 20 20 6q21 64 D 1.00 171 0.282 S b -81 0.73 2.40 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.202 ? 71.43 +P01112 64 Y Q ? P01112 64 Y Q ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.011 -1.116 -4.127 2 237 20 20 6q21 64 D 1.00 171 0.282 S b -49 0.85 2.40 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.125 ? 71.43 +P01112 64 Y R ? P01112 64 Y R ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.994 -1.116 -4.110 2 237 20 20 6q21 64 D 1.00 171 0.282 S b -20 1.41 2.40 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.526 ? 71.43 +P01112 64 Y S ? P01112 64 Y S A C probably damaging alignment ? deleterious 0.999 0.00574 0.136 0.0192 NO NO ? +2.575 -1.116 -3.691 2 237 20 20 6q21 64 D 1.00 171 0.282 S b -104 0.48 2.40 ? ? ? ? ? ? ? 1 1 0 -80 PF00071.17 3.018 ? 71.43 +P01112 64 Y T ? P01112 64 Y T ? ? probably damaging alignment ? deleterious 0.999 0.00574 0.136 0.0192 NO NO ? +2.566 -1.116 -3.682 2 237 20 20 6q21 64 D 1.00 171 0.282 S b -77 0.43 2.40 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 3.513 ? 71.43 +P01112 64 Y V ? P01112 64 Y V ? ? probably damaging alignment ? deleterious 0.984 0.0381 0.743 0.065 NO NO ? +1.533 -1.116 -2.649 2 237 20 20 6q21 64 D 1.00 171 0.282 S b -53 0.23 2.40 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 18.946 18.946 71.43 +P01112 64 Y W ? P01112 64 Y W ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.338 -1.116 -4.454 2 237 20 20 6q21 64 D 1.00 171 0.282 S b 34 0.26 2.40 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.014 ? 71.43 +P01112 65 S A ? P01112 65 S A ? ? benign alignment ? neutral 0.009 0.233 0.961 0.247 NO NO ? +1.039 -1.480 -2.519 2 235 20 20 6q21 65 D 1.00 171 0.960 S l -1 0.27 2.11 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 17.012 17.012 70.37 +P01112 65 S C ? P01112 65 S C A T benign alignment ? neutral 0.051 0.165 0.941 0.192 NO NO ? +1.429 -1.480 -2.909 2 235 20 20 6q21 65 D 1.00 171 0.960 S l 19 0.73 2.11 ? ? ? ? ? ? ? 1 0 0 -82 PF00071.17 23.781 23.781 70.37 +P01112 65 S D ? P01112 65 S D ? ? possibly damaging alignment ? deleterious 0.861 0.0665 0.83 0.0979 NO NO ? +2.140 -1.480 -3.620 2 235 20 20 6q21 65 D 1.00 171 0.960 S l 22 0.48 2.11 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 3.385 ? 70.37 +P01112 65 S E ? P01112 65 S E ? ? possibly damaging alignment ? deleterious 0.812 0.071 0.841 0.103 NO NO ? +1.996 -1.480 -3.476 2 235 20 20 6q21 65 D 1.00 171 0.960 S l 49 0.77 2.11 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 7.268 ? 70.37 +P01112 65 S F ? P01112 65 S F ? ? possibly damaging alignment ? deleterious 0.531 0.0953 0.881 0.128 NO NO ? +1.527 -1.480 -3.007 2 235 20 20 6q21 65 D 1.00 171 0.960 S l 101 0.85 2.11 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 16.927 16.927 70.37 +P01112 65 S G ? P01112 65 S G A G possibly damaging alignment ? deleterious 0.812 0.071 0.841 0.103 NO NO ? +1.851 -1.480 -3.331 2 235 20 20 6q21 65 D 1.00 171 0.960 S l -29 0.02 2.11 ? ? ? ? ? ? ? 0 0 2 -82 PF00071.17 4.602 ? 70.37 +P01112 65 S H ? P01112 65 S H ? ? probably damaging alignment ? deleterious 0.994 0.0289 0.689 0.0537 NO NO ? +3.060 -1.480 -4.540 2 235 20 20 6q21 65 D 1.00 171 0.960 S l 64 0.1 2.11 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.394 ? 70.37 +P01112 65 S I ? P01112 65 S I G T possibly damaging alignment ? deleterious 0.946 0.0537 0.795 0.0839 NO NO ? +2.372 -1.480 -3.852 2 235 20 20 6q21 65 D 1.00 171 0.960 S l 78 0.75 2.11 ? ? ? ? ? ? ? 1 1 0 -83 PF00071.17 3.447 ? 70.37 +P01112 65 S K ? P01112 65 S K ? ? benign alignment ? neutral 0.319 0.112 0.903 0.143 NO NO ? +1.325 -1.480 -2.805 2 235 20 20 6q21 65 D 1.00 171 0.960 S l 79 2.07 2.11 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 15.246 15.246 70.37 +P01112 65 S L ? P01112 65 S L ? ? possibly damaging alignment ? deleterious 0.92 0.0592 0.81 0.0901 NO NO ? +1.916 -1.480 -3.396 2 235 20 20 6q21 65 D 1.00 171 0.960 S l 78 0.82 2.11 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 5.015 ? 70.37 +P01112 65 S M ? P01112 65 S M ? ? probably damaging alignment ? deleterious 0.998 0.0112 0.273 0.0274 NO NO ? +3.122 -1.480 -4.602 2 235 20 20 6q21 65 D 1.00 171 0.960 S l 74 0.82 2.11 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.520 ? 70.37 +P01112 65 S N ? P01112 65 S N G A benign alignment ? neutral 0.353 0.109 0.899 0.141 NO NO ? +2.174 -1.480 -3.654 2 235 20 20 6q21 65 D 1.00 171 0.960 S l 25 0.34 2.11 ? ? ? ? ? ? ? 0 1 0 -83 PF00071.17 3.144 ? 70.37 +P01112 65 S P ? P01112 65 S P ? ? possibly damaging alignment ? deleterious 0.926 0.0582 0.807 0.089 NO NO ? +2.453 -1.480 -3.933 2 235 20 20 6q21 65 D 1.00 171 0.960 S l 23 0.25 2.11 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.739 ? 70.37 +P01112 65 S Q ? P01112 65 S Q ? ? benign alignment ? neutral 0.319 0.112 0.903 0.143 NO NO ? +1.275 -1.480 -2.755 2 235 20 20 6q21 65 D 1.00 171 0.960 S l 55 0.37 2.11 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 15.054 15.054 70.37 +P01112 65 S R ? P01112 65 S R C A probably damaging alignment ? deleterious 0.957 0.0496 0.784 0.079 NO NO ? +2.358 -1.480 -3.838 2 235 20 20 6q21 65 D 1.00 171 0.960 S l 84 0.93 2.11 ? ? ? ? ? ? ? 1 2 1 -84 PF00071.17 5.898 ? 70.37 +P01112 65 S T ? P01112 65 S T G C benign alignment ? neutral 0.011 0.222 0.959 0.239 NO NO ? +1.029 -1.480 -2.509 2 235 20 20 6q21 65 D 1.00 171 0.960 S l 27 0.05 2.11 ? ? ? ? ? ? ? 1 1 0 -83 PF00071.17 16.004 16.004 70.37 +P01112 65 S V ? P01112 65 S V ? ? possibly damaging alignment ? deleterious 0.812 0.071 0.841 0.103 NO NO ? +2.061 -1.480 -3.541 2 235 20 20 6q21 65 D 1.00 171 0.960 S l 51 0.71 2.11 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 4.655 ? 70.37 +P01112 65 S W ? P01112 65 S W ? ? probably damaging alignment ? deleterious 0.998 0.0112 0.273 0.0274 NO NO ? +3.650 -1.480 -5.130 2 235 20 20 6q21 65 D 1.00 171 0.960 S l 138 0.74 2.11 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.396 ? 70.37 +P01112 65 S Y ? P01112 65 S Y ? ? benign alignment ? neutral 0.319 0.112 0.903 0.143 NO NO ? +1.045 -1.480 -2.525 2 235 20 20 6q21 65 D 1.00 171 0.960 S l 104 0.48 2.11 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 16.122 16.122 70.37 +P01112 66 A C ? P01112 66 A C ? ? benign alignment ? neutral 0.437 0.101 0.891 0.134 NO NO ? +1.903 -1.365 -3.268 2 238 20 20 6q21 66 D 1.00 171 0.456 S b 20 0.46 1.60 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 21.736 21.736 77.78 +P01112 66 A D ? P01112 66 A D C A possibly damaging alignment ? deleterious 0.936 0.0568 0.802 0.0876 NO NO ? +2.444 -1.365 -3.809 2 238 20 20 6q21 66 D 1.00 171 0.456 S b 23 0.75 1.60 ? ? ? ? ? ? ? 1 1 0 -86 PF00071.17 3.214 ? 77.78 +P01112 66 A E ? P01112 66 A E ? ? probably damaging alignment ? deleterious 0.964 0.0472 0.777 0.0761 NO NO ? +2.282 -1.365 -3.647 2 238 20 20 6q21 66 D 1.00 171 0.456 S b 50 1.04 1.60 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 3.672 ? 77.78 +P01112 66 A F ? P01112 66 A F ? ? probably damaging alignment ? deleterious 0.993 0.0301 0.696 0.0553 NO NO ? +2.770 -1.365 -4.135 2 238 20 20 6q21 66 D 1.00 171 0.456 S b 102 0.58 1.60 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 5.906 ? 77.78 +P01112 66 A G ? P01112 66 A G C G possibly damaging alignment ? deleterious 0.586 0.093 0.875 0.126 NO NO ? +1.952 -1.365 -3.317 2 238 20 20 6q21 66 D 1.00 171 0.456 S b -28 0.29 1.60 ? ? ? ? ? ? ? 1 1 0 -86 PF00071.17 4.396 ? 77.78 +P01112 66 A H ? P01112 66 A H ? ? probably damaging alignment ? deleterious 0.998 0.0112 0.273 0.0274 NO NO ? +3.385 -1.365 -4.750 2 238 20 20 6q21 66 D 1.00 171 0.456 S b 65 0.17 1.60 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.120 ? 77.78 +P01112 66 A I ? P01112 66 A I ? ? possibly damaging alignment ? deleterious 0.911 0.0607 0.814 0.0918 NO NO ? +1.584 -1.365 -2.949 2 238 20 20 6q21 66 D 1.00 171 0.456 S b 79 0.48 1.60 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 13.217 13.217 77.78 +P01112 66 A K ? P01112 66 A K ? ? probably damaging alignment ? deleterious 0.973 0.044 0.765 0.0723 NO NO ? +2.250 -1.365 -3.615 2 238 20 20 6q21 66 D 1.00 171 0.456 S b 80 2.34 1.60 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 8.499 ? 77.78 +P01112 66 A L ? P01112 66 A L ? ? probably damaging alignment ? deleterious 0.973 0.044 0.765 0.0723 NO NO ? +1.934 -1.365 -3.299 2 238 20 20 6q21 66 D 1.00 171 0.456 S b 79 0.55 1.60 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 10.110 ? 77.78 +P01112 66 A M ? P01112 66 A M ? ? probably damaging alignment ? deleterious 0.998 0.0112 0.273 0.0274 NO NO ? +3.250 -1.365 -4.615 2 238 20 20 6q21 66 D 1.00 171 0.456 S b 75 0.55 1.60 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.466 ? 77.78 +P01112 66 A N ? P01112 66 A N ? ? possibly damaging alignment ? deleterious 0.693 0.0828 0.86 0.115 NO NO ? +2.575 -1.365 -3.940 2 238 20 20 6q21 66 D 1.00 171 0.456 S b 26 0.61 1.60 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 3.607 ? 77.78 +P01112 66 A P ? P01112 66 A P G C benign alignment ? neutral 0.149 0.134 0.922 0.165 NO NO ? +1.111 -1.365 -2.476 2 238 20 20 6q21 66 D 1.00 171 0.456 S b 24 0.52 1.60 ? ? ? ? ? ? ? 1 0 1 -85 PF00071.17 24.344 24.344 77.78 +P01112 66 A Q ? P01112 66 A Q ? ? probably damaging alignment ? deleterious 0.986 0.0368 0.736 0.0634 NO NO ? +2.703 -1.365 -4.068 2 238 20 20 6q21 66 D 1.00 171 0.456 S b 56 0.64 1.60 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 3.389 ? 77.78 +P01112 66 A R ? P01112 66 A R ? ? possibly damaging alignment ? neutral 0.453 0.0997 0.889 0.132 NO NO ? +1.679 -1.365 -3.044 2 238 20 20 6q21 66 D 1.00 171 0.456 S b 85 1.2 1.60 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 24.210 24.210 77.78 +P01112 66 A S ? P01112 66 A S G T benign alignment ? neutral 0.052 0.165 0.94 0.192 NO NO ? +1.007 -1.365 -2.372 2 238 20 20 6q21 66 D 1.00 171 0.456 S b 1 0.27 1.60 ? ? ? ? ? ? ? 1 0 1 -85 PF00071.17 14.429 14.429 77.78 +P01112 66 A T ? P01112 66 A T G A possibly damaging alignment ? deleterious 0.884 0.0642 0.823 0.0956 NO NO ? +1.409 -1.365 -2.774 2 238 20 20 6q21 66 D 1.00 171 0.456 S b 28 0.22 1.60 ? ? ? ? ? ? ? 0 0 1 -85 PF00071.17 12.491 12.491 77.78 +P01112 66 A V ? P01112 66 A V C T benign alignment ? neutral 0.189 0.127 0.917 0.158 NO NO ? +1.377 -1.365 -2.742 2 238 20 20 6q21 66 D 1.00 171 0.456 S b 52 0.44 1.60 ? ? ? ? ? ? ? 0 1 0 -86 PF00071.17 20.940 20.940 77.78 +P01112 66 A W ? P01112 66 A W ? ? probably damaging alignment ? deleterious 0.999 0.00574 0.136 0.0192 NO NO ? +4.014 -1.365 -5.379 2 238 20 20 6q21 66 D 1.00 171 0.456 S b 139 0.47 1.60 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.236 ? 77.78 +P01112 66 A Y ? P01112 66 A Y ? ? possibly damaging alignment ? deleterious 0.78 0.0747 0.848 0.107 NO NO ? +1.762 -1.365 -3.127 2 238 20 20 6q21 66 D 1.00 171 0.456 S b 105 0.21 1.60 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 14.275 14.275 77.78 +P01112 67 M A ? P01112 67 M A ? ? possibly damaging alignment ? deleterious 0.689 0.083 0.861 0.116 NO NO ? +1.674 -1.520 -3.194 2 238 20 20 6q21 67 D 1.00 171 0.790 S a -75 0.55 2.09 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 4.964 ? 71.43 +P01112 67 M C ? P01112 67 M C ? ? probably damaging alignment ? deleterious 0.997 0.0167 0.409 0.0357 NO NO ? +3.281 -1.520 -4.801 2 238 20 20 6q21 67 D 1.00 171 0.790 S a -55 0.09 2.09 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.333 ? 71.43 +P01112 67 M D ? P01112 67 M D ? ? possibly damaging alignment ? deleterious 0.904 0.0621 0.816 0.0934 NO NO ? +2.504 -1.520 -4.024 2 238 20 20 6q21 67 D 1.00 171 0.790 S a -52 1.3 2.09 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.561 ? 71.43 +P01112 67 M E ? P01112 67 M E ? ? possibly damaging alignment ? deleterious 0.653 0.0873 0.866 0.12 NO NO ? +2.265 -1.520 -3.785 2 238 20 20 6q21 67 D 1.00 171 0.790 S a -25 1.59 2.09 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 3.669 ? 71.43 +P01112 67 M F ? P01112 67 M F ? ? benign alignment ? neutral 0.42 0.103 0.892 0.135 NO NO ? +2.265 -1.520 -3.785 2 238 20 20 6q21 67 D 1.00 171 0.790 S a 27 0.03 2.09 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 3.215 ? 71.43 +P01112 67 M G ? P01112 67 M G ? ? probably damaging alignment ? deleterious 0.969 0.045 0.77 0.0734 NO NO ? +2.219 -1.520 -3.739 2 238 20 20 6q21 67 D 1.00 171 0.790 S a -103 0.84 2.09 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.572 ? 71.43 +P01112 67 M H ? P01112 67 M H ? ? benign alignment ? neutral 0.03 0.182 0.947 0.206 NO NO ? +1.289 -1.520 -2.809 2 238 20 20 6q21 67 D 1.00 171 0.790 S a -10 0.72 2.09 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 24.913 24.913 71.43 +P01112 67 M I ? P01112 67 M I G C benign alignment ? neutral 0.113 0.142 0.927 0.172 NO NO ? +1.078 -1.520 -2.598 2 238 20 20 6q21 67 D 1.00 171 0.790 S a 4 0.07 2.09 ? ? ? ? ? ? ? 1 2 0 -90 PF00071.17 11.728 11.206 71.43 +P01112 67 M K ? P01112 67 M K T A possibly damaging alignment ? deleterious 0.684 0.0838 0.862 0.116 NO NO ? +2.159 -1.520 -3.679 2 238 20 20 6q21 67 D 1.00 171 0.790 S a 5 2.89 2.09 ? ? ? ? ? ? ? 1 1 0 -89 PF00071.17 3.188 ? 71.43 +P01112 67 M L ? P01112 67 M L A C benign alignment ? neutral 0.001 0.852 0.994 0.514 NO NO ? +0.245 -1.520 -1.765 2 238 20 20 6q21 67 D 1.00 171 0.790 S a 4 0 2.09 ? ? ? ? ? ? ? 1 0 0 -88 PF00071.17 22.054 22.054 71.43 +P01112 67 M N ? P01112 67 M N ? ? possibly damaging alignment ? deleterious 0.823 0.0698 0.839 0.101 NO NO ? +2.477 -1.520 -3.997 2 238 20 20 6q21 67 D 1.00 171 0.790 S a -49 1.16 2.09 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 3.839 ? 71.43 +P01112 67 M P ? P01112 67 M P ? ? probably damaging alignment ? deleterious 0.966 0.0465 0.775 0.0751 NO NO ? +2.545 -1.520 -4.065 2 238 20 20 6q21 67 D 1.00 171 0.790 S a -51 1.07 2.09 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.282 ? 71.43 +P01112 67 M Q ? P01112 67 M Q ? ? possibly damaging alignment ? deleterious 0.866 0.0661 0.829 0.0975 NO NO ? +2.451 -1.520 -3.971 2 238 20 20 6q21 67 D 1.00 171 0.790 S a -19 1.19 2.09 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.816 ? 71.43 +P01112 67 M R ? P01112 67 M R T G possibly damaging alignment ? deleterious 0.823 0.0698 0.839 0.101 NO NO ? +2.399 -1.520 -3.919 2 238 20 20 6q21 67 D 1.00 171 0.790 S a 10 1.75 2.09 ? ? ? ? ? ? ? 1 1 0 -89 PF00071.17 3.331 ? 71.43 +P01112 67 M S ? P01112 67 M S ? ? possibly damaging alignment ? deleterious 0.939 0.0562 0.8 0.0869 NO NO ? +2.075 -1.520 -3.595 2 238 20 20 6q21 67 D 1.00 171 0.790 S a -74 0.82 2.09 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.967 ? 71.43 +P01112 67 M T ? P01112 67 M T T C possibly damaging alignment ? deleterious 0.779 0.0748 0.848 0.107 NO NO ? +2.018 -1.520 -3.538 2 238 20 20 6q21 67 D 1.00 171 0.790 S a -47 0.77 2.09 ? ? ? ? ? ? ? 0 1 2 -89 PF00071.17 3.566 ? 71.43 +P01112 67 M V ? P01112 67 M V A G benign alignment ? neutral 0.01 0.226 0.96 0.242 NO NO ? +0.780 -1.520 -2.300 2 238 20 20 6q21 67 D 1.00 171 0.790 S a -23 0.11 2.09 ? ? ? ? ? ? ? 0 0 2 -88 PF00071.17 19.231 19.231 71.43 +P01112 67 M W ? P01112 67 M W ? ? probably damaging alignment ? deleterious 0.998 0.0112 0.273 0.0274 NO NO ? +3.621 -1.520 -5.141 2 238 20 20 6q21 67 D 1.00 171 0.790 S a 64 0.08 2.09 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 0.435 ? 71.43 +P01112 67 M Y ? P01112 67 M Y ? ? possibly damaging alignment ? deleterious 0.896 0.063 0.82 0.0944 NO NO ? +2.438 -1.520 -3.958 2 238 20 20 6q21 67 D 1.00 171 0.790 S a 30 0.34 2.09 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 4.084 ? 71.43 +P01112 68 R A ? P01112 68 R A ? ? probably damaging structure 1.1.1 deleterious 0.996 0.0222 0.545 0.0439 NO NO ? +1.502 -0.959 -2.461 2 238 20 20 6q21 68 D 1.00 171 0.013 H A -85 1.2 1.42 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 20.384 20.384 70.37 +P01112 68 R C ? P01112 68 R C ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +4.116 -0.959 -5.075 2 238 20 20 6q21 68 D 1.00 171 0.013 H A -65 1.66 1.42 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.508 ? 70.37 +P01112 68 R D ? P01112 68 R D ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.757 -0.959 -3.716 2 238 20 20 6q21 68 D 1.00 171 0.013 H A -62 0.45 1.42 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.342 ? 70.37 +P01112 68 R E ? P01112 68 R E ? ? probably damaging alignment ? deleterious 0.999 0.00574 0.136 0.0192 NO NO ? +2.296 -0.959 -3.255 2 238 20 20 6q21 68 D 1.00 171 0.013 H A -35 0.16 1.42 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 5.028 ? 70.37 +P01112 68 R F ? P01112 68 R F ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.383 -0.959 -4.342 2 238 20 20 6q21 68 D 1.00 171 0.013 H A 17 1.78 1.42 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.551 ? 70.37 +P01112 68 R G ? P01112 68 R G C G probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.421 -0.959 -3.380 2 238 20 20 6q21 68 D 1.00 171 0.013 H A -113 0.91 1.42 ? ? ? ? ? ? ? 1 0 1 +89 PF00071.17 5.514 ? 70.37 +P01112 68 R H ? P01112 68 R H ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.378 -0.959 -4.337 2 238 20 20 6q21 68 D 1.00 171 0.013 H A -20 1.03 1.42 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.490 ? 70.37 +P01112 68 R I ? P01112 68 R I ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.074 -0.959 -4.033 2 238 20 20 6q21 68 D 1.00 171 0.013 H A -6 1.68 1.42 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 3.023 ? 70.37 +P01112 68 R K ? P01112 68 R K ? ? probably damaging structure 1.1.1 deleterious 1 0.00026 0.00018 0.0109 NO NO ? +1.961 -0.959 -2.920 2 238 20 20 6q21 68 D 1.00 171 0.013 H A -5 1.14 1.42 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 4.400 ? 70.37 +P01112 68 R L ? P01112 68 R L G T probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.449 -0.959 -3.408 2 238 20 20 6q21 68 D 1.00 171 0.013 H A -6 1.75 1.42 ? ? ? ? ? ? ? 1 1 1 +88 PF00071.17 4.190 ? 70.37 +P01112 68 R M ? P01112 68 R M ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.571 -0.959 -4.530 2 238 20 20 6q21 68 D 1.00 171 0.013 H A -10 1.75 1.42 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.272 ? 70.37 +P01112 68 R N ? P01112 68 R N ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.596 -0.959 -3.555 2 238 20 20 6q21 68 D 1.00 171 0.013 H A -59 0.59 1.42 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.175 ? 70.37 +P01112 68 R P ? P01112 68 R P G C probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.948 -0.959 -3.907 2 238 20 20 6q21 68 D 1.00 171 0.013 H A -61 0.68 1.42 ? ? ? ? ? ? ? 1 1 3 +88 PF00071.17 2.045 ? 70.37 +P01112 68 R Q ? P01112 68 R Q G A probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +1.746 -0.959 -2.705 2 238 20 20 6q21 68 D 1.00 171 0.013 H A -29 0.56 1.42 ? ? ? ? ? ? ? 0 1 1 +88 PF00071.17 10.414 10.414 70.37 +P01112 68 R S ? P01112 68 R S ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.427 -0.959 -3.386 2 238 20 20 6q21 68 D 1.00 171 0.013 H A -84 0.93 1.42 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 5.928 ? 70.37 +P01112 68 R T ? P01112 68 R T ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.513 -0.959 -3.472 2 238 20 20 6q21 68 D 1.00 171 0.013 H A -57 0.98 1.42 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 3.525 ? 70.37 +P01112 68 R V ? P01112 68 R V ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.762 -0.959 -3.721 2 238 20 20 6q21 68 D 1.00 171 0.013 H A -33 1.64 1.42 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 4.805 ? 70.37 +P01112 68 R W ? P01112 68 R W C T probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +4.414 -0.959 -5.373 2 238 20 20 6q21 68 D 1.00 171 0.013 H A 54 1.67 1.42 ? ? ? ? ? ? ? 0 0 1 +89 PF00071.17 0.382 ? 70.37 +P01112 68 R Y ? P01112 68 R Y ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.254 -0.959 -4.213 2 238 20 20 6q21 68 D 1.00 171 0.013 H A 20 1.41 1.42 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.233 ? 70.37 +P01112 69 D A ? P01112 69 D A A C possibly damaging alignment ? deleterious 0.919 0.0594 0.811 0.0903 NO NO ? +2.186 -1.156 -3.342 2 238 20 20 6q21 69 D 1.00 171 0.415 H A -23 0.75 1.11 ? ? ? ? ? ? ? 1 1 0 +85 PF00071.17 5.520 ? 82.01 +P01112 69 D C ? P01112 69 D C ? ? probably damaging alignment ? deleterious 0.995 0.0277 0.681 0.0521 NO NO ? +4.088 -1.156 -5.244 2 238 20 20 6q21 69 D 1.00 171 0.415 H A -3 1.21 1.11 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 0.805 ? 82.01 +P01112 69 D E ? P01112 69 D E C G benign alignment ? neutral 0.012 0.219 0.958 0.236 NO NO ? +1.167 -1.156 -2.323 2 238 20 20 6q21 69 D 1.00 171 0.415 H A 27 0.29 1.11 ? ? ? ? ? ? ? 1 2 0 +84 PF00071.17 19.333 19.333 82.01 +P01112 69 D F ? P01112 69 D F ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.272 -1.156 -4.428 2 238 20 20 6q21 69 D 1.00 171 0.415 H A 79 1.33 1.11 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.378 ? 82.01 +P01112 69 D G ? P01112 69 D G A G benign alignment ? neutral 0.158 0.132 0.92 0.163 NO NO ? +1.413 -1.156 -2.569 2 238 20 20 6q21 69 D 1.00 171 0.415 H A -51 0.46 1.11 ? ? ? ? ? ? ? 0 1 0 +85 PF00071.17 35.879 35.879 82.01 +P01112 69 D H ? P01112 69 D H G C probably damaging alignment ? deleterious 0.991 0.0326 0.711 0.0584 NO NO ? +3.331 -1.156 -4.487 2 238 20 20 6q21 69 D 1.00 171 0.415 H A 42 0.58 1.11 ? ? ? ? ? ? ? 1 0 0 +86 PF00071.17 2.627 ? 82.01 +P01112 69 D I ? P01112 69 D I ? ? probably damaging alignment ? deleterious 0.999 0.00574 0.136 0.0192 NO NO ? +3.004 -1.156 -4.160 2 238 20 20 6q21 69 D 1.00 171 0.415 H A 56 1.23 1.11 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.827 ? 82.01 +P01112 69 D K ? P01112 69 D K ? ? possibly damaging alignment ? deleterious 0.841 0.0682 0.836 0.0995 NO NO ? +1.574 -1.156 -2.730 2 238 20 20 6q21 69 D 1.00 171 0.415 H A 57 1.59 1.11 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 18.178 18.178 82.01 +P01112 69 D L ? P01112 69 D L ? ? probably damaging alignment ? deleterious 0.991 0.0326 0.711 0.0584 NO NO ? +2.656 -1.156 -3.812 2 238 20 20 6q21 69 D 1.00 171 0.415 H A 56 1.3 1.11 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.779 ? 82.01 +P01112 69 D M ? P01112 69 D M ? ? probably damaging alignment ? deleterious 0.999 0.00574 0.136 0.0192 NO NO ? +3.754 -1.156 -4.910 2 238 20 20 6q21 69 D 1.00 171 0.415 H A 52 1.3 1.11 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.074 ? 82.01 +P01112 69 D N ? P01112 69 D N G A benign alignment ? neutral 0.046 0.169 0.942 0.195 NO NO ? +1.142 -1.156 -2.298 2 238 20 20 6q21 69 D 1.00 171 0.415 H A 3 0.14 1.11 ? ? ? ? ? ? ? 0 0 0 +86 PF00071.17 25.975 25.975 82.01 +P01112 69 D P ? P01112 69 D P ? ? possibly damaging alignment ? deleterious 0.811 0.071 0.841 0.103 NO NO ? +2.678 -1.156 -3.834 2 238 20 20 6q21 69 D 1.00 171 0.415 H A 1 0.23 1.11 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.779 ? 82.01 +P01112 69 D Q ? P01112 69 D Q ? ? possibly damaging alignment ? deleterious 0.851 0.0673 0.833 0.0987 NO NO ? +1.737 -1.156 -2.893 2 238 20 20 6q21 69 D 1.00 171 0.415 H A 33 0.11 1.11 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 10.640 10.640 82.01 +P01112 69 D R ? P01112 69 D R ? ? probably damaging alignment ? deleterious 0.982 0.0393 0.748 0.0664 NO NO ? +2.644 -1.156 -3.800 2 238 20 20 6q21 69 D 1.00 171 0.415 H A 62 0.45 1.11 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 7.033 ? 82.01 +P01112 69 D S ? P01112 69 D S ? ? possibly damaging alignment ? deleterious 0.937 0.0566 0.801 0.0874 NO NO ? +2.106 -1.156 -3.262 2 238 20 20 6q21 69 D 1.00 171 0.415 H A -22 0.48 1.11 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 5.780 ? 82.01 +P01112 69 D T ? P01112 69 D T ? ? possibly damaging alignment ? deleterious 0.93 0.0578 0.805 0.0887 NO NO ? +2.380 -1.156 -3.536 2 238 20 20 6q21 69 D 1.00 171 0.415 H A 5 0.53 1.11 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 4.107 ? 82.01 +P01112 69 D V ? P01112 69 D V A T probably damaging alignment ? deleterious 0.966 0.0465 0.775 0.0751 NO NO ? +2.674 -1.156 -3.830 2 238 20 20 6q21 69 D 1.00 171 0.415 H A 29 1.19 1.11 ? ? ? ? ? ? ? 1 1 0 +85 PF00071.17 2.207 ? 82.01 +P01112 69 D W ? P01112 69 D W ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +4.411 -1.156 -5.567 2 238 20 20 6q21 69 D 1.00 171 0.415 H A 116 1.22 1.11 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 0.387 ? 82.01 +P01112 69 D Y ? P01112 69 D Y G T probably damaging alignment ? deleterious 0.999 0.00574 0.136 0.0192 NO NO ? +3.255 -1.156 -4.411 2 238 20 20 6q21 69 D 1.00 171 0.415 H A 82 0.96 1.11 ? ? ? ? ? ? ? 1 0 0 +86 PF00071.17 1.287 ? 82.01 +P01112 70 Q A ? P01112 70 Q A ? ? probably damaging alignment ? deleterious 0.96 0.0483 0.781 0.0774 NO NO ? +1.842 -1.407 -3.249 2 239 20 20 6q21 70 D 1.00 171 0.536 H A -56 0.64 1.36 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 5.549 ? 70.37 +P01112 70 Q C ? P01112 70 Q C ? ? probably damaging alignment ? deleterious 0.997 0.0167 0.409 0.0357 NO NO ? +3.806 -1.407 -5.213 2 239 20 20 6q21 70 D 1.00 171 0.536 H A -36 1.1 1.36 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 0.926 ? 70.37 +P01112 70 Q D ? P01112 70 Q D ? ? benign alignment ? neutral 0.228 0.121 0.913 0.152 NO NO ? +1.363 -1.407 -2.770 2 239 20 20 6q21 70 D 1.00 171 0.536 H A -33 0.11 1.36 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 17.002 17.002 70.37 +P01112 70 Q E ? P01112 70 Q E C G benign alignment ? neutral 0.235 0.121 0.912 0.152 NO NO ? +1.023 -1.407 -2.430 2 239 20 20 6q21 70 D 1.00 171 0.536 H A -6 0.4 1.36 ? ? ? ? ? ? ? 1 0 2 +83 PF00071.17 14.774 14.774 70.37 +P01112 70 Q F ? P01112 70 Q F ? ? probably damaging alignment ? deleterious 0.995 0.0277 0.681 0.0521 NO NO ? +2.954 -1.407 -4.361 2 239 20 20 6q21 70 D 1.00 171 0.536 H A 46 1.22 1.36 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.462 ? 70.37 +P01112 70 Q G ? P01112 70 Q G ? ? probably damaging alignment ? deleterious 0.98 0.0405 0.753 0.0679 NO NO ? +2.099 -1.407 -3.506 2 239 20 20 6q21 70 D 1.00 171 0.536 H A -84 0.35 1.36 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 3.403 ? 70.37 +P01112 70 Q H ? P01112 70 Q H G C benign alignment ? neutral 0.143 0.136 0.923 0.166 NO NO ? +1.484 -1.407 -2.891 2 239 20 20 6q21 70 D 1.00 171 0.536 H A 9 0.47 1.36 ? ? ? ? ? ? ? 1 2 0 +81 PF00071.17 22.104 22.104 70.37 +P01112 70 Q I ? P01112 70 Q I ? ? possibly damaging alignment ? deleterious 0.906 0.0617 0.816 0.093 NO NO ? +2.648 -1.407 -4.055 2 239 20 20 6q21 70 D 1.00 171 0.536 H A 23 1.12 1.36 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 5.176 ? 70.37 +P01112 70 Q K ? P01112 70 Q K C A possibly damaging alignment ? neutral 0.461 0.0994 0.888 0.132 NO NO ? +1.299 -1.407 -2.706 2 239 20 20 6q21 70 D 1.00 171 0.536 H A 24 1.7 1.36 ? ? ? ? ? ? ? 1 0 0 +83 PF00071.17 12.754 12.754 70.37 +P01112 70 Q L ? P01112 70 Q L A T benign alignment ? neutral 0.417 0.103 0.893 0.135 NO NO ? +1.439 -1.407 -2.846 2 239 20 20 6q21 70 D 1.00 171 0.536 H A 23 1.19 1.36 ? ? ? ? ? ? ? 1 1 0 +82 PF00071.17 16.888 16.888 70.37 +P01112 70 Q M ? P01112 70 Q M ? ? probably damaging alignment ? deleterious 0.993 0.0301 0.696 0.0553 NO NO ? +3.148 -1.407 -4.555 2 239 20 20 6q21 70 D 1.00 171 0.536 H A 19 1.19 1.36 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.241 ? 70.37 +P01112 70 Q N ? P01112 70 Q N ? ? possibly damaging alignment ? deleterious 0.936 0.0568 0.802 0.0876 NO NO ? +2.214 -1.407 -3.621 2 239 20 20 6q21 70 D 1.00 171 0.536 H A -30 0.0299999999999999 1.36 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 3.406 ? 70.37 +P01112 70 Q P ? P01112 70 Q P A C benign alignment ? neutral 0.112 0.142 0.927 0.172 NO NO ? +1.530 -1.407 -2.937 2 239 20 20 6q21 70 D 1.00 171 0.536 H A -32 0.12 1.36 ? ? ? ? ? ? ? 1 1 2 +82 PF00071.17 34.815 34.815 70.37 +P01112 70 Q R ? P01112 70 Q R A G benign alignment ? neutral 0.319 0.112 0.903 0.143 NO NO ? +1.461 -1.407 -2.868 2 239 20 20 6q21 70 D 1.00 171 0.536 H A 29 0.56 1.36 ? ? ? ? ? ? ? 0 1 2 +82 PF00071.17 15.655 15.655 70.37 +P01112 70 Q S ? P01112 70 Q S ? ? possibly damaging alignment ? deleterious 0.741 0.0787 0.853 0.111 NO NO ? +1.368 -1.407 -2.775 2 239 20 20 6q21 70 D 1.00 171 0.536 H A -55 0.37 1.36 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 11.171 11.171 70.37 +P01112 70 Q T ? P01112 70 Q T ? ? possibly damaging alignment ? deleterious 0.652 0.0875 0.866 0.12 NO NO ? +2.173 -1.407 -3.580 2 239 20 20 6q21 70 D 1.00 171 0.536 H A -28 0.42 1.36 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 4.172 ? 70.37 +P01112 70 Q V ? P01112 70 Q V ? ? possibly damaging alignment ? deleterious 0.853 0.0672 0.832 0.0986 NO NO ? +2.281 -1.407 -3.688 2 239 20 20 6q21 70 D 1.00 171 0.536 H A -4 1.08 1.36 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 4.310 ? 70.37 +P01112 70 Q W ? P01112 70 Q W ? ? probably damaging alignment ? deleterious 0.999 0.00574 0.136 0.0192 NO NO ? +3.967 -1.407 -5.374 2 239 20 20 6q21 70 D 1.00 171 0.536 H A 83 1.11 1.36 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 0.361 ? 70.37 +P01112 70 Q Y ? P01112 70 Q Y ? ? probably damaging alignment ? deleterious 0.964 0.0472 0.777 0.0761 NO NO ? +2.716 -1.407 -4.123 2 239 20 20 6q21 70 D 1.00 171 0.536 H A 49 0.85 1.36 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 3.624 ? 70.37 +P01112 71 Y A ? P01112 71 Y A ? ? possibly damaging structure 1.1.3 deleterious 0.836 0.0687 0.836 0.1 NO NO ? +1.015 -1.483 -2.498 2 239 20 20 6q21 71 D 1.00 171 0.072 H A -105 0.21 1.12 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 12.567 12.567 70.37 +P01112 71 Y C ? P01112 71 Y C A G possibly damaging alignment ? deleterious 0.724 0.0798 0.857 0.112 NO NO ? +1.838 -1.483 -3.321 2 239 20 20 6q21 71 D 1.00 171 0.072 H A -85 0.25 1.12 ? ? ? ? ? ? ? 0 1 0 +79 PF00071.17 31.708 31.708 70.37 +P01112 71 Y D ? P01112 71 Y D T G probably damaging alignment ? deleterious 0.985 0.0375 0.74 0.0643 NO NO ? +2.341 -1.483 -3.824 2 239 20 20 6q21 71 D 1.00 171 0.072 H A -82 0.96 1.12 ? ? ? ? ? ? ? 1 0 0 +80 PF00071.17 3.748 ? 70.37 +P01112 71 Y E ? P01112 71 Y E ? ? probably damaging alignment ? deleterious 0.989 0.0346 0.723 0.0608 NO NO ? +2.232 -1.483 -3.715 2 239 20 20 6q21 71 D 1.00 171 0.072 H A -55 1.25 1.12 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 3.393 ? 70.37 +P01112 71 Y F ? P01112 71 Y F A T benign alignment ? neutral 0.035 0.177 0.945 0.202 NO NO ? +1.173 -1.483 -2.656 2 239 20 20 6q21 71 D 1.00 171 0.072 H A -3 0.37 1.12 ? ? ? ? ? ? ? 1 1 0 +79 PF00071.17 19.171 19.171 70.37 +P01112 71 Y G ? P01112 71 Y G ? ? probably damaging alignment ? deleterious 0.989 0.0346 0.723 0.0608 NO NO ? +2.019 -1.483 -3.502 2 239 20 20 6q21 71 D 1.00 171 0.072 H A -133 0.5 1.12 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 3.403 ? 70.37 +P01112 71 Y H ? P01112 71 Y H T C benign alignment ? neutral 0.183 0.128 0.918 0.159 NO NO ? +1.687 -1.483 -3.170 2 239 20 20 6q21 71 D 1.00 171 0.072 H A -40 0.38 1.12 ? ? ? ? ? ? ? 0 0 0 +80 PF00071.17 23.040 23.040 70.37 +P01112 71 Y I ? P01112 71 Y I ? ? possibly damaging alignment ? deleterious 0.626 0.0893 0.869 0.122 NO NO ? +2.232 -1.483 -3.715 2 239 20 20 6q21 71 D 1.00 171 0.072 H A -26 0.27 1.12 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 11.554 ? 70.37 +P01112 71 Y K ? P01112 71 Y K ? ? possibly damaging alignment ? deleterious 0.913 0.0604 0.813 0.0915 NO NO ? +2.257 -1.483 -3.740 2 239 20 20 6q21 71 D 1.00 171 0.072 H A -25 2.55 1.12 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.948 ? 70.37 +P01112 71 Y L ? P01112 71 Y L ? ? possibly damaging alignment ? deleterious 0.626 0.0893 0.869 0.122 NO NO ? +1.856 -1.483 -3.339 2 239 20 20 6q21 71 D 1.00 171 0.072 H A -26 0.34 1.12 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 9.147 ? 70.37 +P01112 71 Y M ? P01112 71 Y M ? ? probably damaging alignment ? deleterious 0.995 0.0277 0.681 0.0521 NO NO ? +3.157 -1.483 -4.640 2 239 20 20 6q21 71 D 1.00 171 0.072 H A -30 0.34 1.12 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.232 ? 70.37 +P01112 71 Y N ? P01112 71 Y N T A possibly damaging structure 1.1.1 deleterious 0.569 0.0938 0.877 0.127 NO NO ? +1.256 -1.483 -2.739 2 239 20 20 6q21 71 D 1.00 171 0.072 H A -79 0.82 1.12 ? ? ? ? ? ? ? 1 0 0 +80 PF00071.17 14.244 14.244 70.37 +P01112 71 Y P ? P01112 71 Y P ? ? probably damaging alignment ? deleterious 0.998 0.0112 0.273 0.0274 NO NO ? +2.641 -1.483 -4.124 2 239 20 20 6q21 71 D 1.00 171 0.072 H A -81 0.73 1.12 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.479 ? 70.37 +P01112 71 Y Q ? P01112 71 Y Q ? ? probably damaging alignment ? deleterious 0.981 0.0399 0.75 0.0672 NO NO ? +2.599 -1.483 -4.082 2 239 20 20 6q21 71 D 1.00 171 0.072 H A -49 0.85 1.12 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.604 ? 70.37 +P01112 71 Y R ? P01112 71 Y R ? ? probably damaging alignment ? deleterious 0.973 0.044 0.765 0.0723 NO NO ? +2.534 -1.483 -4.017 2 239 20 20 6q21 71 D 1.00 171 0.072 H A -20 1.41 1.12 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 3.080 ? 70.37 +P01112 71 Y S ? P01112 71 Y S A C possibly damaging structure 1.1.3 deleterious 0.626 0.0893 0.869 0.122 NO NO ? +0.973 -1.483 -2.456 2 239 20 20 6q21 71 D 1.00 171 0.072 H A -104 0.48 1.12 ? ? ? ? ? ? ? 1 1 0 +79 PF00071.17 11.171 11.171 70.37 +P01112 71 Y T ? P01112 71 Y T ? ? possibly damaging structure 1.1.3 deleterious 0.925 0.0583 0.808 0.089 NO NO ? +1.379 -1.483 -2.862 2 239 20 20 6q21 71 D 1.00 171 0.072 H A -77 0.43 1.12 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 11.060 11.060 70.37 +P01112 71 Y V ? P01112 71 Y V ? ? possibly damaging alignment ? deleterious 0.636 0.089 0.867 0.122 NO NO ? +1.361 -1.483 -2.844 2 239 20 20 6q21 71 D 1.00 171 0.072 H A -53 0.23 1.12 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 18.946 18.946 70.37 +P01112 71 Y W ? P01112 71 Y W ? ? probably damaging alignment ? deleterious 0.999 0.00574 0.136 0.0192 NO NO ? +3.339 -1.483 -4.822 2 239 20 20 6q21 71 D 1.00 171 0.072 H A 34 0.26 1.12 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 0.891 ? 70.37 +P01112 72 M A ? P01112 72 M A ? ? probably damaging alignment ? deleterious 0.994 0.0289 0.689 0.0537 NO NO ? +1.850 -1.351 -3.201 2 240 20 20 6q21 72 D 1.00 171 0.006 H A -75 0.55 0.72 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 3.052 ? 70.37 +P01112 72 M C ? P01112 72 M C ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.440 -1.351 -4.791 2 240 20 20 6q21 72 D 1.00 171 0.006 H A -55 0.09 0.72 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.032 ? 70.37 +P01112 72 M D ? P01112 72 M D ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.676 -1.351 -4.027 2 240 20 20 6q21 72 D 1.00 171 0.006 H A -52 1.3 0.72 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.561 ? 70.37 +P01112 72 M E ? P01112 72 M E ? ? probably damaging alignment ? deleterious 0.998 0.0112 0.273 0.0274 NO NO ? +2.459 -1.351 -3.810 2 240 20 20 6q21 72 D 1.00 171 0.006 H A -25 1.59 0.72 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 3.669 ? 70.37 +P01112 72 M F ? P01112 72 M F ? ? possibly damaging alignment ? deleterious 0.878 0.0649 0.825 0.0963 NO NO ? +2.423 -1.351 -3.774 2 240 20 20 6q21 72 D 1.00 171 0.006 H A 27 0.03 0.72 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 3.563 ? 70.37 +P01112 72 M G ? P01112 72 M G ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.401 -1.351 -3.752 2 240 20 20 6q21 72 D 1.00 171 0.006 H A -103 0.84 0.72 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.572 ? 70.37 +P01112 72 M H ? P01112 72 M H ? ? benign alignment ? neutral 0.422 0.103 0.892 0.135 NO NO ? +1.815 -1.351 -3.166 2 240 20 20 6q21 72 D 1.00 171 0.006 H A -10 0.72 0.72 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 24.913 24.913 70.37 +P01112 72 M I ? P01112 72 M I G C benign alignment ? neutral 0.16 0.132 0.92 0.163 NO NO ? +0.761 -1.351 -2.112 2 240 20 20 6q21 72 D 1.00 171 0.006 H A 4 0.07 0.72 ? ? ? ? ? ? ? 1 2 0 +75 PF00071.17 13.792 13.792 70.37 +P01112 72 M K ? P01112 72 M K T A probably damaging alignment ? deleterious 0.998 0.0112 0.273 0.0274 NO NO ? +2.341 -1.351 -3.692 2 240 20 20 6q21 72 D 1.00 171 0.006 H A 5 2.89 0.72 ? ? ? ? ? ? ? 1 1 0 +76 PF00071.17 3.188 ? 70.37 +P01112 72 M L ? P01112 72 M L A C benign alignment ? neutral 0.042 0.172 0.943 0.198 NO NO ? +0.773 -1.351 -2.124 2 240 20 20 6q21 72 D 1.00 171 0.006 H A 4 0 0.72 ? ? ? ? ? ? ? 1 0 0 +77 PF00071.17 24.438 24.438 70.37 +P01112 72 M N ? P01112 72 M N ? ? probably damaging alignment ? deleterious 0.999 0.00574 0.136 0.0192 NO NO ? +2.677 -1.351 -4.028 2 240 20 20 6q21 72 D 1.00 171 0.006 H A -49 1.16 0.72 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 3.839 ? 70.37 +P01112 72 M P ? P01112 72 M P ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.716 -1.351 -4.067 2 240 20 20 6q21 72 D 1.00 171 0.006 H A -51 1.07 0.72 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.282 ? 70.37 +P01112 72 M Q ? P01112 72 M Q ? ? probably damaging alignment ? deleterious 0.999 0.00574 0.136 0.0192 NO NO ? +2.619 -1.351 -3.970 2 240 20 20 6q21 72 D 1.00 171 0.006 H A -19 1.19 0.72 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.816 ? 70.37 +P01112 72 M R ? P01112 72 M R T G probably damaging alignment ? deleterious 0.999 0.00574 0.136 0.0192 NO NO ? +2.585 -1.351 -3.936 2 240 20 20 6q21 72 D 1.00 171 0.006 H A 10 1.75 0.72 ? ? ? ? ? ? ? 1 1 0 +76 PF00071.17 3.331 ? 70.37 +P01112 72 M S ? P01112 72 M S ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.238 -1.351 -3.589 2 240 20 20 6q21 72 D 1.00 171 0.006 H A -74 0.82 0.72 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.967 ? 70.37 +P01112 72 M T ? P01112 72 M T T C probably damaging alignment ? deleterious 0.986 0.0368 0.736 0.0634 NO NO ? +2.194 -1.351 -3.545 2 240 20 20 6q21 72 D 1.00 171 0.006 H A -47 0.77 0.72 ? ? ? ? ? ? ? 0 1 2 +76 PF00071.17 2.192 ? 70.37 +P01112 72 M V ? P01112 72 M V A G possibly damaging alignment ? deleterious 0.739 0.0789 0.854 0.111 NO NO ? +1.092 -1.351 -2.443 2 240 20 20 6q21 72 D 1.00 171 0.006 H A -23 0.11 0.72 ? ? ? ? ? ? ? 0 0 2 +77 PF00071.17 11.823 11.823 70.37 +P01112 72 M W ? P01112 72 M W ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.786 -1.351 -5.137 2 240 20 20 6q21 72 D 1.00 171 0.006 H A 64 0.08 0.72 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 0.482 ? 70.37 +P01112 72 M Y ? P01112 72 M Y ? ? probably damaging alignment ? deleterious 0.988 0.0353 0.727 0.0617 NO NO ? +2.646 -1.351 -3.997 2 240 20 20 6q21 72 D 1.00 171 0.006 H A 30 0.34 0.72 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 4.084 ? 70.37 +P01112 73 R A ? P01112 73 R A ? ? benign alignment ? neutral 0.116 0.142 0.927 0.172 NO NO ? +1.264 -1.363 -2.627 2 240 20 20 6q21 73 D 1.00 171 0.641 H A -85 1.2 0.89 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 20.384 20.384 70.37 +P01112 73 R C ? P01112 73 R C C T possibly damaging alignment ? deleterious 0.825 0.0696 0.838 0.101 NO NO ? +1.930 -1.363 -3.293 2 240 20 20 6q21 73 D 1.00 171 0.641 H A -65 1.66 0.89 ? ? ? ? ? ? ? 0 0 1 +74 PF00071.17 21.736 21.736 70.37 +P01112 73 R D ? P01112 73 R D ? ? probably damaging alignment ? deleterious 0.982 0.0393 0.748 0.0664 NO NO ? +2.466 -1.363 -3.829 2 240 20 20 6q21 73 D 1.00 171 0.641 H A -62 0.45 0.89 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.436 ? 70.37 +P01112 73 R E ? P01112 73 R E ? ? possibly damaging alignment ? deleterious 0.892 0.0636 0.821 0.095 NO NO ? +2.134 -1.363 -3.497 2 240 20 20 6q21 73 D 1.00 171 0.641 H A -35 0.16 0.89 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.932 ? 70.37 +P01112 73 R F ? P01112 73 R F ? ? probably damaging alignment ? deleterious 0.988 0.0353 0.727 0.0617 NO NO ? +2.870 -1.363 -4.233 2 240 20 20 6q21 73 D 1.00 171 0.641 H A 17 1.78 0.89 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.491 ? 70.37 +P01112 73 R G ? P01112 73 R G C G probably damaging alignment ? deleterious 0.964 0.0472 0.777 0.0761 NO NO ? +2.143 -1.363 -3.506 2 240 20 20 6q21 73 D 1.00 171 0.641 H A -113 0.91 0.89 ? ? ? ? ? ? ? 1 0 1 +74 PF00071.17 5.514 ? 70.37 +P01112 73 R H ? P01112 73 R H G A possibly damaging alignment ? deleterious 0.705 0.0819 0.859 0.114 NO NO ? +1.524 -1.363 -2.887 2 240 20 20 6q21 73 D 1.00 171 0.641 H A -20 1.03 0.89 ? ? ? ? ? ? ? 0 1 1 +73 PF00071.17 17.421 17.421 70.37 +P01112 73 R I ? P01112 73 R I ? ? possibly damaging alignment ? deleterious 0.621 0.09 0.87 0.123 NO NO ? +1.638 -1.363 -3.001 2 240 20 20 6q21 73 D 1.00 171 0.641 H A -6 1.68 0.89 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 12.212 12.212 70.37 +P01112 73 R K ? P01112 73 R K ? ? benign alignment ? neutral 0.163 0.132 0.92 0.162 NO NO ? +1.310 -1.363 -2.673 2 240 20 20 6q21 73 D 1.00 171 0.641 H A -5 1.14 0.89 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 11.435 11.435 70.37 +P01112 73 R L ? P01112 73 R L G T benign alignment ? neutral 0.308 0.113 0.904 0.144 NO NO ? +1.165 -1.363 -2.528 2 240 20 20 6q21 73 D 1.00 171 0.641 H A -6 1.75 0.89 ? ? ? ? ? ? ? 1 1 1 +73 PF00071.17 17.087 17.087 70.37 +P01112 73 R M ? P01112 73 R M ? ? probably damaging alignment ? deleterious 0.989 0.0346 0.723 0.0608 NO NO ? +3.184 -1.363 -4.547 2 240 20 20 6q21 73 D 1.00 171 0.641 H A -10 1.75 0.89 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.268 ? 70.37 +P01112 73 R N ? P01112 73 R N ? ? probably damaging alignment ? deleterious 0.965 0.047 0.776 0.0757 NO NO ? +2.337 -1.363 -3.700 2 240 20 20 6q21 73 D 1.00 171 0.641 H A -59 0.59 0.89 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.735 ? 70.37 +P01112 73 R P ? P01112 73 R P G C probably damaging alignment ? deleterious 0.991 0.0326 0.711 0.0584 NO NO ? +2.673 -1.363 -4.036 2 240 20 20 6q21 73 D 1.00 171 0.641 H A -61 0.68 0.89 ? ? ? ? ? ? ? 1 1 1 +73 PF00071.17 2.045 ? 70.37 +P01112 73 R Q ? P01112 73 R Q ? ? probably damaging alignment ? deleterious 0.976 0.043 0.76 0.0712 NO NO ? +2.449 -1.363 -3.812 2 240 20 20 6q21 73 D 1.00 171 0.641 H A -29 0.56 0.89 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.198 ? 70.37 +P01112 73 R S ? P01112 73 R S C A possibly damaging alignment ? deleterious 0.757 0.0771 0.852 0.109 NO NO ? +1.236 -1.363 -2.599 2 240 20 20 6q21 73 D 1.00 171 0.641 H A -84 0.93 0.89 ? ? ? ? ? ? ? 1 0 1 +74 PF00071.17 10.938 10.938 70.37 +P01112 73 R T ? P01112 73 R T ? ? probably damaging alignment ? deleterious 0.965 0.047 0.776 0.0757 NO NO ? +2.178 -1.363 -3.541 2 240 20 20 6q21 73 D 1.00 171 0.641 H A -57 0.98 0.89 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 4.085 ? 70.37 +P01112 73 R V ? P01112 73 R V ? ? possibly damaging alignment ? deleterious 0.806 0.072 0.842 0.104 NO NO ? +2.192 -1.363 -3.555 2 240 20 20 6q21 73 D 1.00 171 0.641 H A -33 1.64 0.89 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 7.928 ? 70.37 +P01112 73 R W ? P01112 73 R W ? ? probably damaging alignment ? deleterious 0.999 0.00574 0.136 0.0192 NO NO ? +4.067 -1.363 -5.430 2 240 20 20 6q21 73 D 1.00 171 0.641 H A 54 1.67 0.89 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 0.382 ? 70.37 +P01112 73 R Y ? P01112 73 R Y ? ? probably damaging alignment ? deleterious 0.976 0.043 0.76 0.0712 NO NO ? +2.807 -1.363 -4.170 2 240 20 20 6q21 73 D 1.00 171 0.641 H A 20 1.41 0.89 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.856 ? 70.37 +P01112 74 T A ? P01112 74 T A A G benign alignment ? neutral 0.103 0.144 0.929 0.174 NO NO ? +1.770 -1.363 -3.133 2 240 20 20 6q21 74 D 1.00 171 0.705 H A -28 0.22 0.62 ? ? ? ? ? ? ? 0 0 2 +71 PF00071.17 6.417 ? 70.37 +P01112 74 T C ? P01112 74 T C ? ? probably damaging alignment ? deleterious 0.996 0.0222 0.545 0.0439 NO NO ? +3.540 -1.363 -4.903 2 240 20 20 6q21 74 D 1.00 171 0.705 H A -8 0.68 0.62 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.071 ? 70.37 +P01112 74 T D ? P01112 74 T D ? ? possibly damaging alignment ? deleterious 0.768 0.0762 0.85 0.108 NO NO ? +2.249 -1.363 -3.612 2 240 20 20 6q21 74 D 1.00 171 0.705 H A -5 0.53 0.62 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 3.703 ? 70.37 +P01112 74 T E ? P01112 74 T E ? ? possibly damaging alignment ? deleterious 0.917 0.0597 0.812 0.0907 NO NO ? +2.181 -1.363 -3.544 2 240 20 20 6q21 74 D 1.00 171 0.705 H A 22 0.82 0.62 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 3.669 ? 70.37 +P01112 74 T F ? P01112 74 T F ? ? probably damaging alignment ? deleterious 0.976 0.043 0.76 0.0712 NO NO ? +2.689 -1.363 -4.052 2 240 20 20 6q21 74 D 1.00 171 0.705 H A 74 0.8 0.62 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 3.310 ? 70.37 +P01112 74 T G ? P01112 74 T G ? ? probably damaging alignment ? deleterious 0.965 0.047 0.776 0.0757 NO NO ? +2.009 -1.363 -3.372 2 240 20 20 6q21 74 D 1.00 171 0.705 H A -56 0.07 0.62 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 3.935 ? 70.37 +P01112 74 T H ? P01112 74 T H ? ? benign alignment ? neutral 0.15 0.134 0.921 0.165 NO NO ? +1.761 -1.363 -3.124 2 240 20 20 6q21 74 D 1.00 171 0.705 H A 37 0.05 0.62 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 24.913 24.913 70.37 +P01112 74 T I ? P01112 74 T I C T probably damaging alignment ? deleterious 0.959 0.0488 0.782 0.0779 NO NO ? +2.523 -1.363 -3.886 2 240 20 20 6q21 74 D 1.00 171 0.705 H A 51 0.7 0.62 ? ? ? ? ? ? ? 0 1 0 +70 PF00071.17 1.768 ? 70.37 +P01112 74 T K ? P01112 74 T K ? ? possibly damaging alignment ? deleterious 0.885 0.0641 0.823 0.0954 NO NO ? +2.166 -1.363 -3.529 2 240 20 20 6q21 74 D 1.00 171 0.705 H A 52 2.12 0.62 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 6.007 ? 70.37 +P01112 74 T L ? P01112 74 T L ? ? possibly damaging alignment ? deleterious 0.939 0.0562 0.8 0.0869 NO NO ? +2.047 -1.363 -3.410 2 240 20 20 6q21 74 D 1.00 171 0.705 H A 51 0.77 0.62 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.854 ? 70.37 +P01112 74 T M ? P01112 74 T M ? ? probably damaging alignment ? deleterious 0.997 0.0167 0.409 0.0357 NO NO ? +3.283 -1.363 -4.646 2 240 20 20 6q21 74 D 1.00 171 0.705 H A 47 0.77 0.62 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.027 ? 70.37 +P01112 74 T N ? P01112 74 T N C A benign alignment ? neutral 0.048 0.167 0.941 0.194 NO NO ? +1.175 -1.363 -2.538 2 240 20 20 6q21 74 D 1.00 171 0.705 H A -2 0.39 0.62 ? ? ? ? ? ? ? 1 1 0 +70 PF00071.17 14.077 14.077 70.37 +P01112 74 T P ? P01112 74 T P A C possibly damaging alignment ? deleterious 0.835 0.0687 0.836 0.1 NO NO ? +2.570 -1.363 -3.933 2 240 20 20 6q21 74 D 1.00 171 0.705 H A -4 0.3 0.62 ? ? ? ? ? ? ? 1 0 0 +71 PF00071.17 1.710 ? 70.37 +P01112 74 T Q ? P01112 74 T Q ? ? possibly damaging alignment ? deleterious 0.878 0.0649 0.825 0.0963 NO NO ? +2.591 -1.363 -3.954 2 240 20 20 6q21 74 D 1.00 171 0.705 H A 28 0.42 0.62 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.816 ? 70.37 +P01112 74 T R ? P01112 74 T R ? ? possibly damaging alignment ? deleterious 0.669 0.0853 0.863 0.118 NO NO ? +1.538 -1.363 -2.901 2 240 20 20 6q21 74 D 1.00 171 0.705 H A 57 0.98 0.62 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 17.111 17.111 70.37 +P01112 74 T S ? P01112 74 T S C G benign alignment ? neutral 0.045 0.169 0.942 0.196 NO NO ? +1.065 -1.363 -2.428 2 240 20 20 6q21 74 D 1.00 171 0.705 H A -27 0.05 0.62 ? ? ? ? ? ? ? 1 1 0 +70 PF00071.17 12.916 12.916 70.37 +P01112 74 T V ? P01112 74 T V ? ? probably damaging alignment ? deleterious 0.957 0.0496 0.784 0.079 NO NO ? +2.134 -1.363 -3.497 2 240 20 20 6q21 74 D 1.00 171 0.705 H A 24 0.66 0.62 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.421 ? 70.37 +P01112 74 T W ? P01112 74 T W ? ? benign alignment ? neutral 0.078 0.154 0.933 0.183 NO NO ? +0.985 -1.363 -2.348 2 240 20 20 6q21 74 D 1.00 171 0.705 H A 111 0.69 0.62 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 25.221 25.221 70.37 +P01112 74 T Y ? P01112 74 T Y ? ? probably damaging alignment ? deleterious 0.976 0.043 0.76 0.0712 NO NO ? +2.616 -1.363 -3.979 2 240 20 20 6q21 74 D 1.00 171 0.705 H A 77 0.43 0.62 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 4.084 ? 70.37 +P01112 75 G A ? P01112 75 G A G C probably damaging alignment ? deleterious 0.995 0.0277 0.681 0.0521 NO NO ? +1.372 -0.844 -2.216 2 240 20 20 6q21 75 D 1.00 171 0.046 . B 28 0.29 0.16 ? ? ? ? ? ? ? 1 1 2 +67 PF00071.17 14.713 14.713 50.79 +P01112 75 G C ? P01112 75 G C ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +4.156 -0.844 -5.000 2 240 20 20 6q21 75 D 1.00 171 0.046 . B 48 0.75 0.16 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.088 ? 50.79 +P01112 75 G D ? P01112 75 G D ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.761 -0.844 -3.605 2 240 20 20 6q21 75 D 1.00 171 0.046 . B 51 0.46 0.16 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.022 ? 50.79 +P01112 75 G E ? P01112 75 G E G A probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.865 -0.844 -3.709 2 240 20 20 6q21 75 D 1.00 171 0.046 . B 78 0.75 0.16 ? ? ? ? ? ? ? 0 1 0 +67 PF00071.17 2.130 ? 50.79 +P01112 75 G F ? P01112 75 G F ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.429 -0.844 -4.273 2 240 20 20 6q21 75 D 1.00 171 0.046 . B 130 0.87 0.16 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.230 ? 50.79 +P01112 75 G H ? P01112 75 G H ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.934 -0.844 -4.778 2 240 20 20 6q21 75 D 1.00 171 0.046 . B 93 0.12 0.16 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 0.797 ? 50.79 +P01112 75 G I ? P01112 75 G I ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.109 -0.844 -2.953 2 240 20 20 6q21 75 D 1.00 171 0.046 . B 107 0.77 0.16 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 13.505 13.505 50.79 +P01112 75 G K ? P01112 75 G K ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.882 -0.844 -3.726 2 240 20 20 6q21 75 D 1.00 171 0.046 . B 108 2.05 0.16 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.290 ? 50.79 +P01112 75 G L ? P01112 75 G L ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.735 -0.844 -3.579 2 240 20 20 6q21 75 D 1.00 171 0.046 . B 107 0.84 0.16 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 8.335 ? 50.79 +P01112 75 G M ? P01112 75 G M ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.979 -0.844 -4.823 2 240 20 20 6q21 75 D 1.00 171 0.046 . B 103 0.84 0.16 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.837 ? 50.79 +P01112 75 G N ? P01112 75 G N ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.772 -0.844 -3.616 2 240 20 20 6q21 75 D 1.00 171 0.046 . B 54 0.32 0.16 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.269 ? 50.79 +P01112 75 G P ? P01112 75 G P ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.104 -0.844 -3.948 2 240 20 20 6q21 75 D 1.00 171 0.046 . B 52 0.23 0.16 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.476 ? 50.79 +P01112 75 G Q ? P01112 75 G Q ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.324 -0.844 -4.168 2 240 20 20 6q21 75 D 1.00 171 0.046 . B 84 0.35 0.16 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.365 ? 50.79 +P01112 75 G R ? P01112 75 G R G A probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.157 -0.844 -4.001 2 240 20 20 6q21 75 D 1.00 171 0.046 . B 113 0.91 0.16 ? ? ? ? ? ? ? 0 0 1 +68 PF00071.17 1.634 ? 50.79 +P01112 75 G S ? P01112 75 G S ? ? probably damaging alignment ? deleterious 0.999 0.00574 0.136 0.0192 NO NO ? +1.753 -0.844 -2.597 2 240 20 20 6q21 75 D 1.00 171 0.046 . B 29 0.02 0.16 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 9.076 9.076 50.79 +P01112 75 G T ? P01112 75 G T ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.751 -0.844 -3.595 2 240 20 20 6q21 75 D 1.00 171 0.046 . B 56 0.07 0.16 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 3.390 ? 50.79 +P01112 75 G V ? P01112 75 G V G T probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.699 -0.844 -3.543 2 240 20 20 6q21 75 D 1.00 171 0.046 . B 80 0.73 0.16 ? ? ? ? ? ? ? 1 1 0 +67 PF00071.17 8.768 ? 50.79 +P01112 75 G W ? P01112 75 G W G T probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +4.414 -0.844 -5.258 2 240 20 20 6q21 75 D 1.00 171 0.046 . B 167 0.76 0.16 ? ? ? ? ? ? ? 1 0 1 +68 PF00071.17 0.276 ? 50.79 +P01112 75 G Y ? P01112 75 G Y ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.554 -0.844 -4.398 2 240 20 20 6q21 75 D 1.00 171 0.046 . B 133 0.5 0.16 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.012 ? 50.79 +P01112 76 E A ? P01112 76 E A A C possibly damaging alignment ? deleterious 0.811 0.071 0.841 0.103 NO NO ? +1.723 -1.495 -3.218 2 240 20 20 6q21 76 D 1.00 171 0.219 S A -50 1.04 -0.42 ? ? ? ? ? ? ? 1 1 2 +64 PF00071.17 5.025 ? 82.01 +P01112 76 E C ? P01112 76 E C ? ? probably damaging alignment ? deleterious 0.999 0.00574 0.136 0.0192 NO NO ? +3.752 -1.495 -5.247 2 240 20 20 6q21 76 D 1.00 171 0.219 S A -30 1.5 -0.42 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.258 ? 82.01 +P01112 76 E D ? P01112 76 E D G C benign alignment ? neutral 0.018 0.202 0.953 0.223 NO NO ? +1.006 -1.495 -2.501 2 240 20 20 6q21 76 D 1.00 171 0.219 S A -27 0.29 -0.42 ? ? ? ? ? ? ? 1 2 2 +63 PF00071.17 21.830 21.830 82.01 +P01112 76 E F ? P01112 76 E F ? ? probably damaging alignment ? deleterious 0.998 0.0112 0.273 0.0274 NO NO ? +2.899 -1.495 -4.394 2 240 20 20 6q21 76 D 1.00 171 0.219 S A 52 1.62 -0.42 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.343 ? 82.01 +P01112 76 E G ? P01112 76 E G A G benign alignment ? neutral 0.321 0.112 0.903 0.143 NO NO ? +1.255 -1.495 -2.750 2 240 20 20 6q21 76 D 1.00 171 0.219 S A -78 0.75 -0.42 ? ? ? ? ? ? ? 0 1 0 +64 PF00071.17 25.358 25.358 82.01 +P01112 76 E H ? P01112 76 E H ? ? probably damaging alignment ? deleterious 0.998 0.0112 0.273 0.0274 NO NO ? +3.034 -1.495 -4.529 2 240 20 20 6q21 76 D 1.00 171 0.219 S A 15 0.87 -0.42 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.511 ? 82.01 +P01112 76 E I ? P01112 76 E I ? ? possibly damaging alignment ? deleterious 0.945 0.054 0.796 0.0842 NO NO ? +2.586 -1.495 -4.081 2 240 20 20 6q21 76 D 1.00 171 0.219 S A 29 1.52 -0.42 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 4.939 ? 82.01 +P01112 76 E K ? P01112 76 E K G A possibly damaging alignment ? deleterious 0.53 0.0954 0.881 0.128 NO NO ? +1.024 -1.495 -2.519 2 240 20 20 6q21 76 D 1.00 171 0.219 S A 30 1.3 -0.42 ? ? ? ? ? ? ? 0 0 0 +65 PF00071.17 18.178 18.178 82.01 +P01112 76 E L ? P01112 76 E L ? ? possibly damaging alignment ? deleterious 0.945 0.054 0.796 0.0842 NO NO ? +2.075 -1.495 -3.570 2 240 20 20 6q21 76 D 1.00 171 0.219 S A 29 1.59 -0.42 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 9.706 ? 82.01 +P01112 76 E M ? P01112 76 E M ? ? possibly damaging alignment ? deleterious 0.756 0.0771 0.852 0.109 NO NO ? +1.845 -1.495 -3.340 2 240 20 20 6q21 76 D 1.00 171 0.219 S A 25 1.59 -0.42 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 7.970 7.970 82.01 +P01112 76 E N ? P01112 76 E N ? ? possibly damaging alignment ? deleterious 0.941 0.0556 0.799 0.0862 NO NO ? +2.121 -1.495 -3.616 2 240 20 20 6q21 76 D 1.00 171 0.219 S A -24 0.43 -0.42 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 3.817 ? 82.01 +P01112 76 E P ? P01112 76 E P ? ? possibly damaging alignment ? deleterious 0.912 0.0606 0.814 0.0916 NO NO ? +2.384 -1.495 -3.879 2 240 20 20 6q21 76 D 1.00 171 0.219 S A -26 0.52 -0.42 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.027 ? 82.01 +P01112 76 E Q ? P01112 76 E Q G C benign alignment ? neutral 0.26 0.118 0.91 0.149 NO NO ? +0.855 -1.495 -2.350 2 240 20 20 6q21 76 D 1.00 171 0.219 S A 6 0.4 -0.42 ? ? ? ? ? ? ? 1 0 0 +65 PF00071.17 17.545 17.545 82.01 +P01112 76 E R ? P01112 76 E R ? ? benign alignment ? neutral 0.259 0.118 0.91 0.149 NO NO ? +1.192 -1.495 -2.687 2 240 20 20 6q21 76 D 1.00 171 0.219 S A 35 0.16 -0.42 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 24.210 24.210 82.01 +P01112 76 E S ? P01112 76 E S ? ? possibly damaging alignment ? deleterious 0.701 0.0822 0.859 0.115 NO NO ? +1.269 -1.495 -2.764 2 240 20 20 6q21 76 D 1.00 171 0.219 S A -49 0.77 -0.42 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 9.774 9.774 82.01 +P01112 76 E T ? P01112 76 E T ? ? possibly damaging alignment ? deleterious 0.527 0.0957 0.881 0.128 NO NO ? +1.360 -1.495 -2.855 2 240 20 20 6q21 76 D 1.00 171 0.219 S A -22 0.82 -0.42 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 16.915 16.915 82.01 +P01112 76 E V ? P01112 76 E V A T possibly damaging alignment ? deleterious 0.903 0.0622 0.817 0.0936 NO NO ? +2.176 -1.495 -3.671 2 240 20 20 6q21 76 D 1.00 171 0.219 S A 2 1.48 -0.42 ? ? ? ? ? ? ? 1 1 0 +64 PF00071.17 4.920 ? 82.01 +P01112 76 E W ? P01112 76 E W ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.933 -1.495 -5.428 2 240 20 20 6q21 76 D 1.00 171 0.219 S A 89 1.51 -0.42 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 0.544 ? 82.01 +P01112 76 E Y ? P01112 76 E Y ? ? probably damaging alignment ? deleterious 0.999 0.00574 0.136 0.0192 NO NO ? +2.829 -1.495 -4.324 2 240 20 20 6q21 76 D 1.00 171 0.219 S A 55 1.25 -0.42 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.618 ? 82.01 +P01112 77 G A ? P01112 77 G A G C probably damaging alignment ? deleterious 0.984 0.0381 0.743 0.065 NO NO ? +1.617 -0.816 -2.433 2 239 20 20 6q21 77 D 1.00 171 0.000 E B 28 0.29 -0.83 ? ? ? ? ? ? ? 1 1 0 +61 PF00071.17 22.836 22.836 78.84 +P01112 77 G C ? P01112 77 G C G T probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +4.248 -0.816 -5.064 2 239 20 20 6q21 77 D 1.00 171 0.000 E B 48 0.75 -0.83 ? ? ? ? ? ? ? 1 0 0 +62 PF00071.17 1.689 ? 78.84 +P01112 77 G D ? P01112 77 G D G A probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.839 -0.816 -3.655 2 239 20 20 6q21 77 D 1.00 171 0.000 E B 51 0.46 -0.83 ? ? ? ? ? ? ? 0 1 0 +61 PF00071.17 2.302 ? 78.84 +P01112 77 G E ? P01112 77 G E ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.938 -0.816 -3.754 2 239 20 20 6q21 77 D 1.00 171 0.000 E B 78 0.75 -0.83 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 3.174 ? 78.84 +P01112 77 G F ? P01112 77 G F ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.244 -0.816 -4.060 2 239 20 20 6q21 77 D 1.00 171 0.000 E B 130 0.87 -0.83 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 9.380 ? 78.84 +P01112 77 G H ? P01112 77 G H ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.841 -0.816 -4.657 2 239 20 20 6q21 77 D 1.00 171 0.000 E B 93 0.12 -0.83 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 3.366 ? 78.84 +P01112 77 G I ? P01112 77 G I ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.344 -0.816 -4.160 2 239 20 20 6q21 77 D 1.00 171 0.000 E B 107 0.77 -0.83 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 3.387 ? 78.84 +P01112 77 G K ? P01112 77 G K ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.955 -0.816 -3.771 2 239 20 20 6q21 77 D 1.00 171 0.000 E B 108 2.05 -0.83 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 3.555 ? 78.84 +P01112 77 G L ? P01112 77 G L ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.895 -0.816 -3.711 2 239 20 20 6q21 77 D 1.00 171 0.000 E B 107 0.84 -0.83 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 4.889 ? 78.84 +P01112 77 G M ? P01112 77 G M ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +4.073 -0.816 -4.889 2 239 20 20 6q21 77 D 1.00 171 0.000 E B 103 0.84 -0.83 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.425 ? 78.84 +P01112 77 G N ? P01112 77 G N ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.842 -0.816 -3.658 2 239 20 20 6q21 77 D 1.00 171 0.000 E B 54 0.32 -0.83 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.071 ? 78.84 +P01112 77 G P ? P01112 77 G P ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.183 -0.816 -3.999 2 239 20 20 6q21 77 D 1.00 171 0.000 E B 52 0.23 -0.83 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.291 ? 78.84 +P01112 77 G Q ? P01112 77 G Q ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.360 -0.816 -4.176 2 239 20 20 6q21 77 D 1.00 171 0.000 E B 84 0.35 -0.83 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.044 ? 78.84 +P01112 77 G R ? P01112 77 G R G C probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.206 -0.816 -4.022 2 239 20 20 6q21 77 D 1.00 171 0.000 E B 113 0.91 -0.83 ? ? ? ? ? ? ? 1 0 2 +62 PF00071.17 2.493 ? 78.84 +P01112 77 G S ? P01112 77 G S G A probably damaging alignment ? deleterious 0.999 0.00574 0.136 0.0192 NO NO ? +2.489 -0.816 -3.305 2 239 20 20 6q21 77 D 1.00 171 0.000 E B 29 0.02 -0.83 ? ? ? ? ? ? ? 0 0 0 +62 PF00071.17 6.642 ? 78.84 +P01112 77 G T ? P01112 77 G T ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.877 -0.816 -3.693 2 239 20 20 6q21 77 D 1.00 171 0.000 E B 56 0.07 -0.83 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 3.949 ? 78.84 +P01112 77 G V ? P01112 77 G V G T probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.910 -0.816 -3.726 2 239 20 20 6q21 77 D 1.00 171 0.000 E B 80 0.73 -0.83 ? ? ? ? ? ? ? 1 1 0 +61 PF00071.17 5.383 ? 78.84 +P01112 77 G W ? P01112 77 G W ? ? probably damaging alignment ? deleterious 0.998 0.0112 0.273 0.0274 NO NO ? +2.243 -0.816 -3.059 2 239 20 20 6q21 77 D 1.00 171 0.000 E B 167 0.76 -0.83 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 24.696 24.696 78.84 +P01112 77 G Y ? P01112 77 G Y ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.100 -0.816 -2.916 2 239 20 20 6q21 77 D 1.00 171 0.000 E B 133 0.5 -0.83 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 22.671 22.671 78.84 +P01112 78 F A ? P01112 78 F A ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.355 -0.977 -3.332 2 240 20 20 6q21 78 D 1.00 171 0.000 E B -102 0.58 -1.26 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 3.782 ? 84.66 +P01112 78 F C ? P01112 78 F C T G probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.953 -0.977 -4.930 2 240 20 20 6q21 78 D 1.00 171 0.000 E B -82 0.12 -1.26 ? ? ? ? ? ? ? 1 1 0 +58 PF00071.17 1.342 ? 84.66 +P01112 78 F D ? P01112 78 F D ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.002 -0.977 -3.979 2 240 20 20 6q21 78 D 1.00 171 0.000 E B -79 1.33 -1.26 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.091 ? 84.66 +P01112 78 F E ? P01112 78 F E ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.876 -0.977 -3.853 2 240 20 20 6q21 78 D 1.00 171 0.000 E B -52 1.62 -1.26 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 3.534 ? 84.66 +P01112 78 F G ? P01112 78 F G ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.694 -0.977 -3.671 2 240 20 20 6q21 78 D 1.00 171 0.000 E B -130 0.87 -1.26 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.172 ? 84.66 +P01112 78 F H ? P01112 78 F H ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.610 -0.977 -4.587 2 240 20 20 6q21 78 D 1.00 171 0.000 E B -37 0.75 -1.26 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.015 ? 84.66 +P01112 78 F I ? P01112 78 F I T A probably damaging alignment ? deleterious 0.999 0.00574 0.136 0.0192 NO NO ? +2.410 -0.977 -3.387 2 240 20 20 6q21 78 D 1.00 171 0.000 E B -23 0.1 -1.26 ? ? ? ? ? ? ? 1 0 0 +59 PF00071.17 9.742 ? 84.66 +P01112 78 F K ? P01112 78 F K ? ? probably damaging structure 1.1.1 deleterious 0.999 0.00574 0.136 0.0192 NO NO ? +1.824 -0.977 -2.801 2 240 20 20 6q21 78 D 1.00 171 0.000 E B -22 2.92 -1.26 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 13.780 13.780 84.66 +P01112 78 F L ? P01112 78 F L T C possibly damaging alignment ? deleterious 0.922 0.0588 0.809 0.0896 NO NO ? +1.245 -0.977 -2.222 2 240 20 20 6q21 78 D 1.00 171 0.000 E B -23 0.03 -1.26 ? ? ? ? ? ? ? 0 0 0 +59 PF00071.17 31.790 31.790 84.66 +P01112 78 F M ? P01112 78 F M ? ? probably damaging alignment ? deleterious 0.987 0.036 0.731 0.0626 NO NO ? +3.306 -0.977 -4.283 2 240 20 20 6q21 78 D 1.00 171 0.000 E B -27 0.03 -1.26 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 4.219 ? 84.66 +P01112 78 F N ? P01112 78 F N ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.148 -0.977 -4.125 2 240 20 20 6q21 78 D 1.00 171 0.000 E B -76 1.19 -1.26 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.087 ? 84.66 +P01112 78 F P ? P01112 78 F P ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.325 -0.977 -4.302 2 240 20 20 6q21 78 D 1.00 171 0.000 E B -78 1.1 -1.26 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.349 ? 84.66 +P01112 78 F Q ? P01112 78 F Q ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.306 -0.977 -4.283 2 240 20 20 6q21 78 D 1.00 171 0.000 E B -46 1.22 -1.26 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.648 ? 84.66 +P01112 78 F R ? P01112 78 F R ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.069 -0.977 -4.046 2 240 20 20 6q21 78 D 1.00 171 0.000 E B -17 1.78 -1.26 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 5.331 ? 84.66 +P01112 78 F S ? P01112 78 F S T C probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.668 -0.977 -3.645 2 240 20 20 6q21 78 D 1.00 171 0.000 E B -101 0.85 -1.26 ? ? ? ? ? ? ? 0 1 0 +58 PF00071.17 2.653 ? 84.66 +P01112 78 F T ? P01112 78 F T ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.699 -0.977 -3.676 2 240 20 20 6q21 78 D 1.00 171 0.000 E B -74 0.8 -1.26 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.845 ? 84.66 +P01112 78 F V ? P01112 78 F V T G probably damaging alignment ? deleterious 0.999 0.00574 0.136 0.0192 NO NO ? +2.354 -0.977 -3.331 2 240 20 20 6q21 78 D 1.00 171 0.000 E B -50 0.14 -1.26 ? ? ? ? ? ? ? 1 0 2 +59 PF00071.17 8.113 ? 84.66 +P01112 78 F W ? P01112 78 F W ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.653 -0.977 -4.630 2 240 20 20 6q21 78 D 1.00 171 0.000 E B 37 0.11 -1.26 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 0.627 ? 84.66 +P01112 78 F Y ? P01112 78 F Y T A probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.291 -0.977 -3.268 2 240 20 20 6q21 78 D 1.00 171 0.000 E B 3 0.37 -1.26 ? ? ? ? ? ? ? 1 1 0 +58 PF00071.17 1.891 ? 84.66 +P01112 79 L A ? P01112 79 L A ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.221 -0.929 -3.150 2 240 20 20 6q21 79 D 1.00 171 0.000 E B -79 0.55 -0.81 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 4.413 ? 70.37 +P01112 79 L C ? P01112 79 L C ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.832 -0.929 -4.761 2 240 20 20 6q21 79 D 1.00 171 0.000 E B -59 0.09 -0.81 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.185 ? 70.37 +P01112 79 L D ? P01112 79 L D ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.191 -0.929 -4.120 2 240 20 20 6q21 79 D 1.00 171 0.000 E B -56 1.3 -0.81 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.259 ? 70.37 +P01112 79 L E ? P01112 79 L E ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.987 -0.929 -3.916 2 240 20 20 6q21 79 D 1.00 171 0.000 E B -29 1.59 -0.81 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.596 ? 70.37 +P01112 79 L F ? P01112 79 L F ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.850 -0.929 -3.779 2 240 20 20 6q21 79 D 1.00 171 0.000 E B 23 0.03 -0.81 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.243 ? 70.37 +P01112 79 L G ? P01112 79 L G ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.905 -0.929 -3.834 2 240 20 20 6q21 79 D 1.00 171 0.000 E B -107 0.84 -0.81 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.491 ? 70.37 +P01112 79 L H ? P01112 79 L H ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +4.048 -0.929 -4.977 2 240 20 20 6q21 79 D 1.00 171 0.000 E B -14 0.72 -0.81 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 0.872 ? 70.37 +P01112 79 L I ? P01112 79 L I ? ? probably damaging alignment ? deleterious 0.975 0.0436 0.762 0.072 NO NO ? +1.547 -0.929 -2.476 2 240 20 20 6q21 79 D 1.00 171 0.000 E B 0 0.07 -0.81 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 13.361 13.361 70.37 +P01112 79 L K ? P01112 79 L K ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.842 -0.929 -3.771 2 240 20 20 6q21 79 D 1.00 171 0.000 E B 1 2.89 -0.81 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.880 ? 70.37 +P01112 79 L M ? P01112 79 L M C A probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.056 -0.929 -3.985 2 240 20 20 6q21 79 D 1.00 171 0.000 E B -4 0 -0.81 ? ? ? ? ? ? ? 1 0 0 +56 PF00071.17 2.013 ? 70.37 +P01112 79 L N ? P01112 79 L N ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.266 -0.929 -4.195 2 240 20 20 6q21 79 D 1.00 171 0.000 E B -53 1.16 -0.81 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.571 ? 70.37 +P01112 79 L P ? P01112 79 L P T C probably damaging structure 1.1.1 deleterious 1 0.00026 0.00018 0.0109 NO NO ? +1.908 -0.929 -2.837 2 240 20 20 6q21 79 D 1.00 171 0.000 E B -55 1.07 -0.81 ? ? ? ? ? ? ? 0 1 2 +55 PF00071.17 34.815 34.815 70.37 +P01112 79 L Q ? P01112 79 L Q T A probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.284 -0.929 -4.213 2 240 20 20 6q21 79 D 1.00 171 0.000 E B -23 1.19 -0.81 ? ? ? ? ? ? ? 1 1 0 +55 PF00071.17 1.546 ? 70.37 +P01112 79 L R ? P01112 79 L R T G probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.131 -0.929 -4.060 2 240 20 20 6q21 79 D 1.00 171 0.000 E B 6 1.75 -0.81 ? ? ? ? ? ? ? 1 1 2 +55 PF00071.17 1.749 ? 70.37 +P01112 79 L S ? P01112 79 L S ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.754 -0.929 -3.683 2 240 20 20 6q21 79 D 1.00 171 0.000 E B -78 0.82 -0.81 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 3.043 ? 70.37 +P01112 79 L T ? P01112 79 L T ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.564 -0.929 -3.493 2 240 20 20 6q21 79 D 1.00 171 0.000 E B -51 0.77 -0.81 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 3.170 ? 70.37 +P01112 79 L V ? P01112 79 L V C G probably damaging alignment ? deleterious 0.974 0.0438 0.763 0.0722 NO NO ? +1.483 -0.929 -2.412 2 240 20 20 6q21 79 D 1.00 171 0.000 E B -27 0.11 -0.81 ? ? ? ? ? ? ? 1 0 2 +56 PF00071.17 17.094 17.094 70.37 +P01112 79 L W ? P01112 79 L W ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +4.328 -0.929 -5.257 2 240 20 20 6q21 79 D 1.00 171 0.000 E B 60 0.08 -0.81 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 0.310 ? 70.37 +P01112 79 L Y ? P01112 79 L Y ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.132 -0.929 -4.061 2 240 20 20 6q21 79 D 1.00 171 0.000 E B 26 0.34 -0.81 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.349 ? 70.37 +P01112 80 C A ? P01112 80 C A ? ? probably damaging alignment ? deleterious 0.959 0.0488 0.782 0.0779 NO NO ? +1.489 -1.667 -3.156 2 238 20 20 6q21 80 D 1.00 171 0.010 E B -20 0.46 -0.75 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 3.475 ? 77.78 +P01112 80 C D ? P01112 80 C D ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.469 -1.667 -4.136 2 238 20 20 6q21 80 D 1.00 171 0.010 E B 3 1.21 -0.75 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.195 ? 77.78 +P01112 80 C E ? P01112 80 C E ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.420 -1.667 -4.087 2 238 20 20 6q21 80 D 1.00 171 0.010 E B 30 1.5 -0.75 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.725 ? 77.78 +P01112 80 C F ? P01112 80 C F G T possibly damaging structure 1.1.2 deleterious 0.73 0.0795 0.855 0.112 NO NO ? +1.054 -1.667 -2.721 2 238 20 20 6q21 80 D 1.00 171 0.010 E B 82 0.12 -0.75 ? ? ? ? ? ? ? 1 1 0 +52 PF00071.17 19.579 19.579 77.78 +P01112 80 C G ? P01112 80 C G T G probably damaging alignment ? deleterious 0.989 0.0346 0.723 0.0608 NO NO ? +2.160 -1.667 -3.827 2 238 20 20 6q21 80 D 1.00 171 0.010 E B -48 0.75 -0.75 ? ? ? ? ? ? ? 1 0 0 +53 PF00071.17 1.862 ? 77.78 +P01112 80 C H ? P01112 80 C H ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.327 -1.667 -4.994 2 238 20 20 6q21 80 D 1.00 171 0.010 E B 45 0.63 -0.75 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 0.972 ? 77.78 +P01112 80 C I ? P01112 80 C I ? ? possibly damaging alignment ? deleterious 0.529 0.0955 0.881 0.128 NO NO ? +0.695 -1.667 -2.362 2 238 20 20 6q21 80 D 1.00 171 0.010 E B 59 0.02 -0.75 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 13.792 13.792 77.78 +P01112 80 C K ? P01112 80 C K ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.276 -1.667 -3.943 2 238 20 20 6q21 80 D 1.00 171 0.010 E B 60 2.8 -0.75 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.309 ? 77.78 +P01112 80 C L ? P01112 80 C L ? ? benign alignment ? neutral 0.221 0.122 0.914 0.153 NO NO ? +0.049 -1.667 -1.716 2 238 20 20 6q21 80 D 1.00 171 0.010 E B 59 0.09 -0.75 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 29.207 29.207 77.78 +P01112 80 C M ? P01112 80 C M ? ? probably damaging alignment ? deleterious 0.978 0.0417 0.756 0.0695 NO NO ? +1.214 -1.667 -2.881 2 238 20 20 6q21 80 D 1.00 171 0.010 E B 55 0.09 -0.75 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 10.284 10.284 77.78 +P01112 80 C N ? P01112 80 C N ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.595 -1.667 -4.262 2 238 20 20 6q21 80 D 1.00 171 0.010 E B 6 1.07 -0.75 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.345 ? 77.78 +P01112 80 C P ? P01112 80 C P ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.580 -1.667 -4.247 2 238 20 20 6q21 80 D 1.00 171 0.010 E B 4 0.98 -0.75 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.112 ? 77.78 +P01112 80 C Q ? P01112 80 C Q ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.686 -1.667 -4.353 2 238 20 20 6q21 80 D 1.00 171 0.010 E B 36 1.1 -0.75 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.880 ? 77.78 +P01112 80 C R ? P01112 80 C R T C probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.541 -1.667 -4.208 2 238 20 20 6q21 80 D 1.00 171 0.010 E B 65 1.66 -0.75 ? ? ? ? ? ? ? 0 0 2 +53 PF00071.17 2.040 ? 77.78 +P01112 80 C S ? P01112 80 C S G C probably damaging alignment ? deleterious 0.992 0.0314 0.704 0.0568 NO NO ? +1.998 -1.667 -3.665 2 238 20 20 6q21 80 D 1.00 171 0.010 E B -19 0.73 -0.75 ? ? ? ? ? ? ? 1 1 0 +52 PF00071.17 2.175 ? 77.78 +P01112 80 C T ? P01112 80 C T ? ? probably damaging alignment ? deleterious 0.994 0.0289 0.689 0.0537 NO NO ? +1.920 -1.667 -3.587 2 238 20 20 6q21 80 D 1.00 171 0.010 E B 8 0.68 -0.75 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.614 ? 77.78 +P01112 80 C V ? P01112 80 C V ? ? possibly damaging alignment ? deleterious 0.739 0.0789 0.854 0.111 NO NO ? +0.935 -1.667 -2.602 2 238 20 20 6q21 80 D 1.00 171 0.010 E B 32 0.02 -0.75 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 11.823 11.823 77.78 +P01112 80 C W ? P01112 80 C W T G probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.520 -1.667 -5.187 2 238 20 20 6q21 80 D 1.00 171 0.010 E B 119 0.01 -0.75 ? ? ? ? ? ? ? 1 2 0 +51 PF00071.17 0.910 ? 77.78 +P01112 80 C Y ? P01112 80 C Y G A probably damaging alignment ? deleterious 0.991 0.0326 0.711 0.0584 NO NO ? +2.371 -1.667 -4.038 2 238 20 20 6q21 80 D 1.00 171 0.010 E B 85 0.25 -0.75 ? ? ? ? ? ? ? 0 1 0 +52 PF00071.17 4.541 ? 77.78 +P01112 81 V A ? P01112 81 V A T C possibly damaging alignment ? deleterious 0.546 0.0947 0.879 0.127 NO NO ? +1.134 -1.127 -2.261 2 238 20 20 6q21 81 D 1.00 171 0.000 E B -52 0.44 -0.85 ? ? ? ? ? ? ? 0 1 2 +49 PF00071.17 23.602 23.602 81.48 +P01112 81 V C ? P01112 81 V C ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.619 -1.127 -4.746 2 238 20 20 6q21 81 D 1.00 171 0.000 E B -32 0.02 -0.85 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.746 ? 81.48 +P01112 81 V D ? P01112 81 V D ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.853 -1.127 -3.980 2 238 20 20 6q21 81 D 1.00 171 0.000 E B -29 1.19 -0.85 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.380 ? 81.48 +P01112 81 V E ? P01112 81 V E T A probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.598 -1.127 -3.725 2 238 20 20 6q21 81 D 1.00 171 0.000 E B -2 1.48 -0.85 ? ? ? ? ? ? ? 1 1 0 +49 PF00071.17 3.672 ? 81.48 +P01112 81 V F ? P01112 81 V F ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.827 -1.127 -3.954 2 238 20 20 6q21 81 D 1.00 171 0.000 E B 50 0.14 -0.85 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.800 ? 81.48 +P01112 81 V G ? P01112 81 V G T G probably damaging alignment ? deleterious 0.998 0.0112 0.273 0.0274 NO NO ? +2.462 -1.127 -3.589 2 238 20 20 6q21 81 D 1.00 171 0.000 E B -80 0.73 -0.85 ? ? ? ? ? ? ? 1 1 0 +49 PF00071.17 6.385 ? 81.48 +P01112 81 V H ? P01112 81 V H ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.770 -1.127 -4.897 2 238 20 20 6q21 81 D 1.00 171 0.000 E B 13 0.61 -0.85 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.692 ? 81.48 +P01112 81 V I ? P01112 81 V I ? ? possibly damaging alignment ? deleterious 0.731 0.0795 0.855 0.112 NO NO ? +1.162 -1.127 -2.289 2 238 20 20 6q21 81 D 1.00 171 0.000 E B 27 0.04 -0.85 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 16.953 16.953 81.48 +P01112 81 V K ? P01112 81 V K ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.534 -1.127 -3.661 2 238 20 20 6q21 81 D 1.00 171 0.000 E B 28 2.78 -0.85 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 8.499 ? 81.48 +P01112 81 V L ? P01112 81 V L G C possibly damaging alignment ? deleterious 0.849 0.0674 0.834 0.0988 NO NO ? +1.698 -1.127 -2.825 2 238 20 20 6q21 81 D 1.00 171 0.000 E B 27 0.11 -0.85 ? ? ? ? ? ? ? 1 0 0 +50 PF00071.17 11.167 ? 81.48 +P01112 81 V M ? P01112 81 V M G A probably damaging alignment ? deleterious 0.994 0.0289 0.689 0.0537 NO NO ? +1.916 -1.127 -3.043 2 238 20 20 6q21 81 D 1.00 171 0.000 E B 23 0.11 -0.85 ? ? ? ? ? ? ? 0 0 0 +50 PF00071.17 9.170 9.170 81.48 +P01112 81 V N ? P01112 81 V N ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.988 -1.127 -4.115 2 238 20 20 6q21 81 D 1.00 171 0.000 E B -26 1.05 -0.85 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.698 ? 81.48 +P01112 81 V P ? P01112 81 V P ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.857 -1.127 -3.984 2 238 20 20 6q21 81 D 1.00 171 0.000 E B -28 0.96 -0.85 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.368 ? 81.48 +P01112 81 V Q ? P01112 81 V Q ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.989 -1.127 -4.116 2 238 20 20 6q21 81 D 1.00 171 0.000 E B 4 1.08 -0.85 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 3.389 ? 81.48 +P01112 81 V R ? P01112 81 V R ? ? probably damaging structure 1.1.1 deleterious 0.995 0.0277 0.681 0.0521 NO NO ? +1.827 -1.127 -2.954 2 238 20 20 6q21 81 D 1.00 171 0.000 E B 33 1.64 -0.85 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 24.210 24.210 81.48 +P01112 81 V S ? P01112 81 V S ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.452 -1.127 -3.579 2 238 20 20 6q21 81 D 1.00 171 0.000 E B -51 0.71 -0.85 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 6.865 ? 81.48 +P01112 81 V T ? P01112 81 V T ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.236 -1.127 -3.363 2 238 20 20 6q21 81 D 1.00 171 0.000 E B -24 0.66 -0.85 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 4.082 ? 81.48 +P01112 81 V W ? P01112 81 V W ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +4.262 -1.127 -5.389 2 238 20 20 6q21 81 D 1.00 171 0.000 E B 87 0.03 -0.85 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 0.450 ? 81.48 +P01112 81 V Y ? P01112 81 V Y ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.960 -1.127 -4.087 2 238 20 20 6q21 81 D 1.00 171 0.000 E B 53 0.23 -0.85 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.427 ? 81.48 +P01112 82 F A ? P01112 82 F A ? ? probably damaging structure 1.1.3 deleterious 0.994 0.0289 0.689 0.0537 NO NO ? +1.781 -1.496 -3.277 2 238 20 20 6q21 82 D 1.00 171 0.000 E B -102 0.58 -1.28 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 7.110 ? 70.90 +P01112 82 F C ? P01112 82 F C T G probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.420 -1.496 -4.916 2 238 20 20 6q21 82 D 1.00 171 0.000 E B -82 0.12 -1.28 ? ? ? ? ? ? ? 1 1 0 +46 PF00071.17 1.313 ? 70.90 +P01112 82 F D ? P01112 82 F D ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.440 -1.496 -3.936 2 238 20 20 6q21 82 D 1.00 171 0.000 E B -79 1.33 -1.28 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 3.188 ? 70.90 +P01112 82 F E ? P01112 82 F E ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.301 -1.496 -3.797 2 238 20 20 6q21 82 D 1.00 171 0.000 E B -52 1.62 -1.28 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 3.359 ? 70.90 +P01112 82 F G ? P01112 82 F G ? ? probably damaging alignment ? deleterious 0.998 0.0112 0.273 0.0274 NO NO ? +2.105 -1.496 -3.601 2 238 20 20 6q21 82 D 1.00 171 0.000 E B -130 0.87 -1.28 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 4.360 ? 70.90 +P01112 82 F H ? P01112 82 F H ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.738 -1.496 -4.234 2 238 20 20 6q21 82 D 1.00 171 0.000 E B -37 0.75 -1.28 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 3.341 ? 70.90 +P01112 82 F I ? P01112 82 F I T A probably damaging alignment ? deleterious 0.994 0.0289 0.689 0.0537 NO NO ? +1.969 -1.496 -3.465 2 238 20 20 6q21 82 D 1.00 171 0.000 E B -23 0.1 -1.28 ? ? ? ? ? ? ? 1 0 0 +47 PF00071.17 11.554 ? 70.90 +P01112 82 F K ? P01112 82 F K ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.318 -1.496 -3.814 2 238 20 20 6q21 82 D 1.00 171 0.000 E B -22 2.92 -1.28 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 3.527 ? 70.90 +P01112 82 F L ? P01112 82 F L T C probably damaging alignment ? deleterious 0.98 0.0405 0.753 0.0679 NO NO ? +1.605 -1.496 -3.101 2 238 20 20 6q21 82 D 1.00 171 0.000 E B -23 0.03 -1.28 ? ? ? ? ? ? ? 0 0 0 +47 PF00071.17 9.147 ? 70.90 +P01112 82 F M ? P01112 82 F M ? ? possibly damaging alignment ? deleterious 0.953 0.0514 0.788 0.0812 NO NO ? +2.937 -1.496 -4.433 2 238 20 20 6q21 82 D 1.00 171 0.000 E B -27 0.03 -1.28 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.232 ? 70.90 +P01112 82 F N ? P01112 82 F N ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.517 -1.496 -4.013 2 238 20 20 6q21 82 D 1.00 171 0.000 E B -76 1.19 -1.28 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 3.578 ? 70.90 +P01112 82 F P ? P01112 82 F P ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.719 -1.496 -4.215 2 238 20 20 6q21 82 D 1.00 171 0.000 E B -78 1.1 -1.28 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.895 ? 70.90 +P01112 82 F Q ? P01112 82 F Q ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.657 -1.496 -4.153 2 238 20 20 6q21 82 D 1.00 171 0.000 E B -46 1.22 -1.28 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.153 ? 70.90 +P01112 82 F R ? P01112 82 F R ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.615 -1.496 -4.111 2 238 20 20 6q21 82 D 1.00 171 0.000 E B -17 1.78 -1.28 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.577 ? 70.90 +P01112 82 F S ? P01112 82 F S T C possibly damaging structure 1.1.3 deleterious 0.866 0.0661 0.829 0.0975 NO NO ? +1.272 -1.496 -2.768 2 238 20 20 6q21 82 D 1.00 171 0.000 E B -101 0.85 -1.28 ? ? ? ? ? ? ? 0 1 0 +46 PF00071.17 14.312 14.312 70.90 +P01112 82 F T ? P01112 82 F T ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.125 -1.496 -3.621 2 238 20 20 6q21 82 D 1.00 171 0.000 E B -74 0.8 -1.28 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 5.345 ? 70.90 +P01112 82 F V ? P01112 82 F V T G possibly damaging alignment ? deleterious 0.833 0.0689 0.837 0.1 NO NO ? +1.149 -1.496 -2.645 2 238 20 20 6q21 82 D 1.00 171 0.000 E B -50 0.14 -1.28 ? ? ? ? ? ? ? 1 0 0 +47 PF00071.17 18.946 18.946 70.90 +P01112 82 F W ? P01112 82 F W ? ? probably damaging alignment ? deleterious 0.999 0.00574 0.136 0.0192 NO NO ? +3.015 -1.496 -4.511 2 238 20 20 6q21 82 D 1.00 171 0.000 E B 37 0.11 -1.28 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.949 ? 70.90 +P01112 82 F Y ? P01112 82 F Y T A benign alignment ? neutral 0.185 0.128 0.917 0.159 NO NO ? -0.015 -1.496 -1.481 2 238 20 20 6q21 82 D 1.00 171 0.000 E B 3 0.37 -1.28 ? ? ? ? ? ? ? 1 1 0 +46 PF00071.17 22.503 22.503 70.90 +P01112 83 A C ? P01112 83 A C ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.511 -1.236 -4.747 2 238 20 20 6q21 83 D 1.00 171 0.029 E B 20 0.46 -0.86 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.196 ? 70.37 +P01112 83 A D ? P01112 83 A D C A possibly damaging alignment ? deleterious 0.747 0.0781 0.853 0.11 NO NO ? +1.079 -1.236 -2.315 2 238 20 20 6q21 83 D 1.00 171 0.029 E B 23 0.75 -0.86 ? ? ? ? ? ? ? 1 1 0 +43 PF00071.17 22.670 22.670 70.37 +P01112 83 A E ? P01112 83 A E ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.157 -1.236 -3.393 2 238 20 20 6q21 83 D 1.00 171 0.029 E B 50 1.04 -0.86 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 5.238 ? 70.37 +P01112 83 A F ? P01112 83 A F ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.022 -1.236 -4.258 2 238 20 20 6q21 83 D 1.00 171 0.029 E B 102 0.58 -0.86 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.369 ? 70.37 +P01112 83 A G ? P01112 83 A G C G benign alignment ? neutral 0.224 0.121 0.913 0.153 NO NO ? +1.240 -1.236 -2.476 2 238 20 20 6q21 83 D 1.00 171 0.029 E B -28 0.29 -0.86 ? ? ? ? ? ? ? 1 1 0 +43 PF00071.17 22.391 22.391 70.37 +P01112 83 A H ? P01112 83 A H ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.453 -1.236 -4.689 2 238 20 20 6q21 83 D 1.00 171 0.029 E B 65 0.17 -0.86 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.692 ? 70.37 +P01112 83 A I ? P01112 83 A I ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.627 -1.236 -3.863 2 238 20 20 6q21 83 D 1.00 171 0.029 E B 79 0.48 -0.86 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.975 ? 70.37 +P01112 83 A K ? P01112 83 A K ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.249 -1.236 -3.485 2 238 20 20 6q21 83 D 1.00 171 0.029 E B 80 2.34 -0.86 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 8.499 ? 70.37 +P01112 83 A L ? P01112 83 A L ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.208 -1.236 -3.444 2 238 20 20 6q21 83 D 1.00 171 0.029 E B 79 0.55 -0.86 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 3.299 ? 70.37 +P01112 83 A M ? P01112 83 A M ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.457 -1.236 -4.693 2 238 20 20 6q21 83 D 1.00 171 0.029 E B 75 0.55 -0.86 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.095 ? 70.37 +P01112 83 A N ? P01112 83 A N ? ? probably damaging alignment ? deleterious 0.99 0.0338 0.719 0.06 NO NO ? +2.437 -1.236 -3.673 2 238 20 20 6q21 83 D 1.00 171 0.029 E B 26 0.61 -0.86 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 3.964 ? 70.37 +P01112 83 A P ? P01112 83 A P G C probably damaging alignment ? deleterious 0.999 0.00574 0.136 0.0192 NO NO ? +2.580 -1.236 -3.816 2 238 20 20 6q21 83 D 1.00 171 0.029 E B 24 0.52 -0.86 ? ? ? ? ? ? ? 1 0 0 +44 PF00071.17 1.910 ? 70.37 +P01112 83 A Q ? P01112 83 A Q ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.685 -1.236 -3.921 2 238 20 20 6q21 83 D 1.00 171 0.029 E B 56 0.64 -0.86 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 3.389 ? 70.37 +P01112 83 A R ? P01112 83 A R ? ? probably damaging structure 1.1.1 deleterious 0.999 0.00574 0.136 0.0192 NO NO ? +1.682 -1.236 -2.918 2 238 20 20 6q21 83 D 1.00 171 0.029 E B 85 1.2 -0.86 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 24.210 24.210 70.37 +P01112 83 A S ? P01112 83 A S G T benign alignment ? neutral 0.15 0.134 0.921 0.165 NO NO ? +0.705 -1.236 -1.941 2 238 20 20 6q21 83 D 1.00 171 0.029 E B 1 0.27 -0.86 ? ? ? ? ? ? ? 1 0 0 +44 PF00071.17 14.429 14.429 70.37 +P01112 83 A T ? P01112 83 A T G A probably damaging alignment ? deleterious 0.995 0.0277 0.681 0.0521 NO NO ? +2.106 -1.236 -3.342 2 238 20 20 6q21 83 D 1.00 171 0.029 E B 28 0.22 -0.86 ? ? ? ? ? ? ? 0 0 0 +44 PF00071.17 5.389 ? 70.37 +P01112 83 A V ? P01112 83 A V C T probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.222 -1.236 -3.458 2 238 20 20 6q21 83 D 1.00 171 0.029 E B 52 0.44 -0.86 ? ? ? ? ? ? ? 0 1 0 +43 PF00071.17 2.704 ? 70.37 +P01112 83 A W ? P01112 83 A W ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +4.230 -1.236 -5.466 2 238 20 20 6q21 83 D 1.00 171 0.029 E B 139 0.47 -0.86 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 0.362 ? 70.37 +P01112 83 A Y ? P01112 83 A Y ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.103 -1.236 -4.339 2 238 20 20 6q21 83 D 1.00 171 0.029 E B 105 0.21 -0.86 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.263 ? 70.37 +P01112 84 I A ? P01112 84 I A ? ? possibly damaging alignment ? deleterious 0.938 0.0564 0.801 0.0871 NO NO ? +1.514 -1.650 -3.164 2 238 20 20 6q21 84 D 1.00 171 0.000 T A -79 0.48 -0.82 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 5.479 ? 79.89 +P01112 84 I C ? P01112 84 I C ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.179 -1.650 -4.829 2 238 20 20 6q21 84 D 1.00 171 0.000 T A -59 0.02 -0.82 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.471 ? 79.89 +P01112 84 I D ? P01112 84 I D ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.371 -1.650 -4.021 2 238 20 20 6q21 84 D 1.00 171 0.000 T A -56 1.23 -0.82 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.561 ? 79.89 +P01112 84 I E ? P01112 84 I E ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.216 -1.650 -3.866 2 238 20 20 6q21 84 D 1.00 171 0.000 T A -29 1.52 -0.82 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 3.669 ? 79.89 +P01112 84 I F ? P01112 84 I F A T benign alignment ? neutral 0.131 0.139 0.925 0.169 NO NO ? +1.301 -1.650 -2.951 2 238 20 20 6q21 84 D 1.00 171 0.000 T A 23 0.1 -0.82 ? ? ? ? ? ? ? 1 0 0 +41 PF00071.17 26.513 26.513 79.89 +P01112 84 I G ? P01112 84 I G ? ? probably damaging alignment ? deleterious 0.995 0.0277 0.681 0.0521 NO NO ? +2.142 -1.650 -3.792 2 238 20 20 6q21 84 D 1.00 171 0.000 T A -107 0.77 -0.82 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.572 ? 79.89 +P01112 84 I H ? P01112 84 I H ? ? possibly damaging alignment ? deleterious 0.94 0.056 0.799 0.0867 NO NO ? +1.604 -1.650 -3.254 2 238 20 20 6q21 84 D 1.00 171 0.000 T A -14 0.65 -0.82 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 24.913 24.913 79.89 +P01112 84 I K ? P01112 84 I K ? ? probably damaging alignment ? deleterious 0.99 0.0338 0.719 0.06 NO NO ? +2.217 -1.650 -3.867 2 238 20 20 6q21 84 D 1.00 171 0.000 T A 1 2.82 -0.82 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 3.188 ? 79.89 +P01112 84 I L ? P01112 84 I L A C benign alignment ? neutral 0.002 0.704 0.987 0.452 NO NO ? +0.591 -1.650 -2.241 2 238 20 20 6q21 84 D 1.00 171 0.000 T A 0 0.07 -0.82 ? ? ? ? ? ? ? 1 0 0 +41 PF00071.17 30.002 30.002 79.89 +P01112 84 I M ? P01112 84 I M C G possibly damaging alignment ? deleterious 0.578 0.0935 0.875 0.126 NO NO ? +1.488 -1.650 -3.138 2 238 20 20 6q21 84 D 1.00 171 0.000 T A -4 0.07 -0.82 ? ? ? ? ? ? ? 1 2 0 +39 PF00071.17 12.941 12.941 79.89 +P01112 84 I N ? P01112 84 I N T A probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.469 -1.650 -4.119 2 238 20 20 6q21 84 D 1.00 171 0.000 T A -53 1.09 -0.82 ? ? ? ? ? ? ? 1 1 0 +40 PF00071.17 3.839 ? 79.89 +P01112 84 I P ? P01112 84 I P ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.481 -1.650 -4.131 2 238 20 20 6q21 84 D 1.00 171 0.000 T A -55 1 -0.82 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.346 ? 79.89 +P01112 84 I Q ? P01112 84 I Q ? ? probably damaging alignment ? deleterious 0.999 0.00574 0.136 0.0192 NO NO ? +2.618 -1.650 -4.268 2 238 20 20 6q21 84 D 1.00 171 0.000 T A -23 1.12 -0.82 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.816 ? 79.89 +P01112 84 I R ? P01112 84 I R ? ? probably damaging alignment ? deleterious 0.999 0.00574 0.136 0.0192 NO NO ? +2.515 -1.650 -4.165 2 238 20 20 6q21 84 D 1.00 171 0.000 T A 6 1.68 -0.82 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 3.331 ? 79.89 +P01112 84 I S ? P01112 84 I S T G probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.025 -1.650 -3.675 2 238 20 20 6q21 84 D 1.00 171 0.000 T A -78 0.75 -0.82 ? ? ? ? ? ? ? 1 1 0 +40 PF00071.17 4.056 ? 79.89 +P01112 84 I T ? P01112 84 I T T C probably damaging alignment ? deleterious 0.978 0.0417 0.756 0.0695 NO NO ? +1.130 -1.650 -2.780 2 238 20 20 6q21 84 D 1.00 171 0.000 T A -51 0.7 -0.82 ? ? ? ? ? ? ? 0 1 0 +40 PF00071.17 10.799 10.799 79.89 +P01112 84 I V ? P01112 84 I V A G benign alignment ? neutral 0 1 1 0.575 NO NO ? -0.074 -1.650 -1.576 2 238 20 20 6q21 84 D 1.00 171 0.000 T A -27 0.04 -0.82 ? ? ? ? ? ? ? 0 0 2 +41 PF00071.17 21.225 21.225 79.89 +P01112 84 I W ? P01112 84 I W ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.655 -1.650 -5.305 2 238 20 20 6q21 84 D 1.00 171 0.000 T A 60 0.01 -0.82 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.232 ? 79.89 +P01112 84 I Y ? P01112 84 I Y ? ? probably damaging alignment ? deleterious 0.987 0.036 0.731 0.0626 NO NO ? +2.309 -1.650 -3.959 2 238 20 20 6q21 84 D 1.00 171 0.000 T A 26 0.27 -0.82 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 6.149 ? 79.89 +P01112 85 N A ? P01112 85 N A ? ? benign alignment ? neutral 0.256 0.118 0.911 0.15 NO NO ? +1.586 -1.662 -3.248 2 238 20 20 6q21 85 D 1.00 171 0.381 T a -26 0.61 -0.75 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 5.180 ? 75.66 +P01112 85 N C ? P01112 85 N C ? ? benign alignment ? neutral 0.229 0.121 0.912 0.152 NO NO ? +1.706 -1.662 -3.368 2 238 20 20 6q21 85 D 1.00 171 0.381 T a -6 1.07 -0.75 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 21.480 21.480 75.66 +P01112 85 N D ? P01112 85 N D A G benign alignment ? neutral 0.011 0.222 0.959 0.239 NO NO ? +0.764 -1.662 -2.426 2 238 20 20 6q21 85 D 1.00 171 0.381 T a -3 0.14 -0.75 ? ? ? ? ? ? ? 0 0 2 +38 PF00071.17 30.016 30.016 75.66 +P01112 85 N E ? P01112 85 N E ? ? possibly damaging alignment ? deleterious 0.78 0.0747 0.848 0.107 NO NO ? +1.817 -1.662 -3.479 2 238 20 20 6q21 85 D 1.00 171 0.381 T a 24 0.43 -0.75 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 7.268 ? 75.66 +P01112 85 N F ? P01112 85 N F ? ? probably damaging alignment ? deleterious 0.979 0.0411 0.755 0.0687 NO NO ? +2.537 -1.662 -4.199 2 238 20 20 6q21 85 D 1.00 171 0.381 T a 76 1.19 -0.75 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 9.033 ? 75.66 +P01112 85 N G ? P01112 85 N G ? ? benign alignment ? neutral 0.228 0.121 0.913 0.152 NO NO ? +1.050 -1.662 -2.712 2 238 20 20 6q21 85 D 1.00 171 0.381 T a -54 0.32 -0.75 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 25.898 25.898 75.66 +P01112 85 N H ? P01112 85 N H A C probably damaging alignment ? deleterious 0.99 0.0338 0.719 0.06 NO NO ? +2.859 -1.662 -4.521 2 238 20 20 6q21 85 D 1.00 171 0.381 T a 39 0.44 -0.75 ? ? ? ? ? ? ? 1 0 0 +38 PF00071.17 3.242 ? 75.66 +P01112 85 N I ? P01112 85 N I A T benign alignment ? neutral 0.347 0.109 0.9 0.141 NO NO ? +1.138 -1.662 -2.800 2 238 20 20 6q21 85 D 1.00 171 0.381 T a 53 1.09 -0.75 ? ? ? ? ? ? ? 1 1 0 +37 PF00071.17 17.671 17.671 75.66 +P01112 85 N K ? P01112 85 N K C G probably damaging alignment ? deleterious 0.972 0.0442 0.766 0.0725 NO NO ? +1.943 -1.662 -3.605 2 238 20 20 6q21 85 D 1.00 171 0.381 T a 54 1.73 -0.75 ? ? ? ? ? ? ? 1 2 0 +36 PF00071.17 6.361 ? 75.66 +P01112 85 N L ? P01112 85 N L ? ? possibly damaging alignment ? deleterious 0.832 0.069 0.837 0.101 NO NO ? +1.787 -1.662 -3.449 2 238 20 20 6q21 85 D 1.00 171 0.381 T a 53 1.16 -0.75 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 10.907 ? 75.66 +P01112 85 N M ? P01112 85 N M ? ? probably damaging alignment ? deleterious 0.996 0.0222 0.545 0.0439 NO NO ? +3.046 -1.662 -4.708 2 238 20 20 6q21 85 D 1.00 171 0.381 T a 49 1.16 -0.75 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.403 ? 75.66 +P01112 85 N P ? P01112 85 N P ? ? possibly damaging alignment ? deleterious 0.938 0.0564 0.801 0.0871 NO NO ? +2.357 -1.662 -4.019 2 238 20 20 6q21 85 D 1.00 171 0.381 T a -2 0.09 -0.75 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.882 ? 75.66 +P01112 85 N Q ? P01112 85 N Q ? ? possibly damaging alignment ? deleterious 0.63 0.0891 0.868 0.122 NO NO ? +1.447 -1.662 -3.109 2 238 20 20 6q21 85 D 1.00 171 0.381 T a 30 0.0299999999999999 -0.75 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 15.054 15.054 75.66 +P01112 85 N R ? P01112 85 N R ? ? probably damaging alignment ? deleterious 0.979 0.0411 0.755 0.0687 NO NO ? +2.244 -1.662 -3.906 2 238 20 20 6q21 85 D 1.00 171 0.381 T a 59 0.59 -0.75 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 5.106 ? 75.66 +P01112 85 N S ? P01112 85 N S A G benign alignment ? neutral 0.128 0.14 0.925 0.17 NO NO ? +0.904 -1.662 -2.566 2 238 20 20 6q21 85 D 1.00 171 0.381 T a -25 0.34 -0.75 ? ? ? ? ? ? ? 0 1 0 +37 PF00071.17 9.658 9.658 75.66 +P01112 85 N T ? P01112 85 N T A C benign alignment ? neutral 0.032 0.18 0.946 0.205 NO NO ? +0.625 -1.662 -2.287 2 238 20 20 6q21 85 D 1.00 171 0.381 T a 2 0.39 -0.75 ? ? ? ? ? ? ? 1 1 0 +37 PF00071.17 17.435 17.435 75.66 +P01112 85 N V ? P01112 85 N V ? ? benign alignment ? neutral 0.056 0.163 0.939 0.19 NO NO ? +1.209 -1.662 -2.871 2 238 20 20 6q21 85 D 1.00 171 0.381 T a 26 1.05 -0.75 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 15.812 15.812 75.66 +P01112 85 N W ? P01112 85 N W ? ? probably damaging alignment ? deleterious 0.999 0.00574 0.136 0.0192 NO NO ? +3.758 -1.662 -5.420 2 238 20 20 6q21 85 D 1.00 171 0.381 T a 113 1.08 -0.75 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.891 ? 75.66 +P01112 85 N Y ? P01112 85 N Y A T benign alignment ? neutral 0.445 0.1 0.889 0.133 NO NO ? +1.507 -1.662 -3.169 2 238 20 20 6q21 85 D 1.00 171 0.381 T a 79 0.82 -0.75 ? ? ? ? ? ? ? 1 0 0 +38 PF00071.17 21.832 21.832 75.66 +P01112 86 N A ? P01112 86 N A ? ? benign alignment ? neutral 0.087 0.15 0.932 0.179 NO NO ? +1.378 -1.852 -3.230 2 237 20 20 6q21 86 D 1.00 171 0.375 . b -26 0.61 -0.26 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 8.613 ? 78.84 +P01112 86 N C ? P01112 86 N C ? ? benign alignment ? neutral 0.033 0.179 0.946 0.204 NO NO ? +1.116 -1.852 -2.968 2 237 20 20 6q21 86 D 1.00 171 0.375 . b -6 1.07 -0.26 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 23.781 23.781 78.84 +P01112 86 N D ? P01112 86 N D A G benign alignment ? neutral 0 1 1 0.575 NO NO ? +0.009 -1.852 -1.861 2 237 20 20 6q21 86 D 1.00 171 0.375 . b -3 0.14 -0.26 ? ? ? ? ? ? ? 0 0 2 +35 PF00071.17 21.830 21.830 78.84 +P01112 86 N E ? P01112 86 N E ? ? benign alignment ? neutral 0.006 0.253 0.967 0.262 NO NO ? +0.475 -1.852 -2.327 2 237 20 20 6q21 86 D 1.00 171 0.375 . b 24 0.43 -0.26 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 22.790 22.790 78.84 +P01112 86 N F ? P01112 86 N F ? ? possibly damaging alignment ? deleterious 0.928 0.058 0.806 0.0888 NO NO ? +2.395 -1.852 -4.247 2 237 20 20 6q21 86 D 1.00 171 0.375 . b 76 1.19 -0.26 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 7.087 ? 78.84 +P01112 86 N G ? P01112 86 N G ? ? possibly damaging alignment ? deleterious 0.711 0.0814 0.858 0.114 NO NO ? +1.433 -1.852 -3.285 2 237 20 20 6q21 86 D 1.00 171 0.375 . b -54 0.32 -0.26 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 5.282 ? 78.84 +P01112 86 N H ? P01112 86 N H A C possibly damaging alignment ? deleterious 0.936 0.0568 0.802 0.0876 NO NO ? +2.580 -1.852 -4.432 2 237 20 20 6q21 86 D 1.00 171 0.375 . b 39 0.44 -0.26 ? ? ? ? ? ? ? 1 0 0 +35 PF00071.17 2.543 ? 78.84 +P01112 86 N I ? P01112 86 N I A T possibly damaging alignment ? deleterious 0.936 0.0568 0.802 0.0876 NO NO ? +2.205 -1.852 -4.057 2 237 20 20 6q21 86 D 1.00 171 0.375 . b 53 1.09 -0.26 ? ? ? ? ? ? ? 1 1 0 +34 PF00071.17 2.373 ? 78.84 +P01112 86 N K ? P01112 86 N K C G possibly damaging alignment ? deleterious 0.734 0.0794 0.854 0.112 NO NO ? +1.621 -1.852 -3.473 2 237 20 20 6q21 86 D 1.00 171 0.375 . b 54 1.73 -0.26 ? ? ? ? ? ? ? 1 2 0 +33 PF00071.17 6.361 ? 78.84 +P01112 86 N L ? P01112 86 N L ? ? possibly damaging alignment ? deleterious 0.732 0.0795 0.855 0.112 NO NO ? +1.806 -1.852 -3.658 2 237 20 20 6q21 86 D 1.00 171 0.375 . b 53 1.16 -0.26 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 3.694 ? 78.84 +P01112 86 N M ? P01112 86 N M ? ? probably damaging alignment ? deleterious 0.996 0.0222 0.545 0.0439 NO NO ? +2.954 -1.852 -4.806 2 237 20 20 6q21 86 D 1.00 171 0.375 . b 49 1.16 -0.26 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.520 ? 78.84 +P01112 86 N P ? P01112 86 N P ? ? possibly damaging alignment ? deleterious 0.807 0.0718 0.841 0.104 NO NO ? +2.086 -1.852 -3.938 2 237 20 20 6q21 86 D 1.00 171 0.375 . b -2 0.09 -0.26 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.295 ? 78.84 +P01112 86 N Q ? P01112 86 N Q ? ? benign alignment ? neutral 0.163 0.132 0.92 0.162 NO NO ? +1.135 -1.852 -2.987 2 237 20 20 6q21 86 D 1.00 171 0.375 . b 30 0.0299999999999999 -0.26 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 15.054 15.054 78.84 +P01112 86 N R ? P01112 86 N R ? ? possibly damaging alignment ? deleterious 0.928 0.058 0.806 0.0888 NO NO ? +1.991 -1.852 -3.843 2 237 20 20 6q21 86 D 1.00 171 0.375 . b 59 0.59 -0.26 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 5.106 ? 78.84 +P01112 86 N S ? P01112 86 N S A G benign alignment ? neutral 0.003 0.556 0.981 0.39 NO NO ? +0.209 -1.852 -2.061 2 237 20 20 6q21 86 D 1.00 171 0.375 . b -25 0.34 -0.26 ? ? ? ? ? ? ? 0 1 0 +34 PF00071.17 17.338 17.338 78.84 +P01112 86 N T ? P01112 86 N T A C benign alignment ? neutral 0.255 0.118 0.911 0.15 NO NO ? +1.595 -1.852 -3.447 2 237 20 20 6q21 86 D 1.00 171 0.375 . b 2 0.39 -0.26 ? ? ? ? ? ? ? 1 1 0 +34 PF00071.17 6.475 ? 78.84 +P01112 86 N V ? P01112 86 N V ? ? benign alignment ? neutral 0.445 0.1 0.889 0.133 NO NO ? +1.909 -1.852 -3.761 2 237 20 20 6q21 86 D 1.00 171 0.375 . b 26 1.05 -0.26 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 3.249 ? 78.84 +P01112 86 N W ? P01112 86 N W ? ? probably damaging alignment ? deleterious 0.998 0.0112 0.273 0.0274 NO NO ? +3.578 -1.852 -5.430 2 237 20 20 6q21 86 D 1.00 171 0.375 . b 113 1.08 -0.26 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.484 ? 78.84 +P01112 86 N Y ? P01112 86 N Y A T benign alignment ? neutral 0.281 0.116 0.908 0.147 NO NO ? +1.271 -1.852 -3.123 2 237 20 20 6q21 86 D 1.00 171 0.375 . b 79 0.82 -0.26 ? ? ? ? ? ? ? 1 0 0 +35 PF00071.17 17.129 17.129 78.84 +P01112 87 T A ? P01112 87 T A A G benign alignment ? neutral 0 1 1 0.575 NO NO ? -0.131 -2.558 -2.427 2 238 20 20 6q21 87 D 1.00 171 0.396 H A -28 0.22 -0.69 ? ? ? ? ? ? ? 0 0 2 +32 PF00071.17 22.989 22.989 86.24 +P01112 87 T C ? P01112 87 T C ? ? possibly damaging alignment ? deleterious 0.805 0.0722 0.842 0.104 NO NO ? +2.549 -2.558 -5.107 2 238 20 20 6q21 87 D 1.00 171 0.396 H A -8 0.68 -0.69 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.701 ? 86.24 +P01112 87 T D ? P01112 87 T D ? ? benign alignment ? neutral 0.001 0.852 0.994 0.514 NO NO ? +0.601 -2.558 -3.159 2 238 20 20 6q21 87 D 1.00 171 0.396 H A -5 0.53 -0.69 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 31.276 31.276 86.24 +P01112 87 T E ? P01112 87 T E ? ? benign alignment ? neutral 0.021 0.196 0.951 0.219 NO NO ? +0.516 -2.558 -3.074 2 238 20 20 6q21 87 D 1.00 171 0.396 H A 22 0.82 -0.69 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 13.046 13.046 86.24 +P01112 87 T F ? P01112 87 T F ? ? benign alignment ? neutral 0.027 0.186 0.948 0.21 NO NO ? +0.539 -2.558 -3.097 2 238 20 20 6q21 87 D 1.00 171 0.396 H A 74 0.8 -0.69 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 18.967 18.967 86.24 +P01112 87 T G ? P01112 87 T G ? ? benign alignment ? neutral 0.004 0.408 0.975 0.328 NO NO ? +0.445 -2.558 -3.003 2 238 20 20 6q21 87 D 1.00 171 0.396 H A -56 0.07 -0.69 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 38.846 38.846 86.24 +P01112 87 T H ? P01112 87 T H ? ? benign alignment ? neutral 0.006 0.253 0.967 0.262 NO NO ? +0.990 -2.558 -3.548 2 238 20 20 6q21 87 D 1.00 171 0.396 H A 37 0.05 -0.69 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 24.913 24.913 86.24 +P01112 87 T I ? P01112 87 T I C T benign alignment ? neutral 0.001 0.852 0.994 0.514 NO NO ? +0.258 -2.558 -2.816 2 238 20 20 6q21 87 D 1.00 171 0.396 H A 51 0.7 -0.69 ? ? ? ? ? ? ? 0 1 0 +31 PF00071.17 22.556 22.556 86.24 +P01112 87 T K ? P01112 87 T K ? ? benign alignment ? neutral 0.004 0.408 0.975 0.328 NO NO ? +0.300 -2.558 -2.858 2 238 20 20 6q21 87 D 1.00 171 0.396 H A 52 2.12 -0.69 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 16.273 16.273 86.24 +P01112 87 T L ? P01112 87 T L ? ? benign alignment ? neutral 0 1 1 0.575 NO NO ? -0.075 -2.558 -2.483 2 238 20 20 6q21 87 D 1.00 171 0.396 H A 51 0.77 -0.69 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 28.412 28.412 86.24 +P01112 87 T M ? P01112 87 T M ? ? benign alignment ? neutral 0.138 0.137 0.923 0.167 NO NO ? +1.000 -2.558 -3.558 2 238 20 20 6q21 87 D 1.00 171 0.396 H A 47 0.77 -0.69 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 11.827 11.827 86.24 +P01112 87 T N ? P01112 87 T N C A benign alignment ? neutral 0.025 0.189 0.949 0.213 NO NO ? +1.347 -2.558 -3.905 2 238 20 20 6q21 87 D 1.00 171 0.396 H A -2 0.39 -0.69 ? ? ? ? ? ? ? 1 1 0 +31 PF00071.17 5.469 ? 86.24 +P01112 87 T P ? P01112 87 T P A C benign alignment ? neutral 0 1 1 0.575 NO NO ? +0.454 -2.558 -3.012 2 238 20 20 6q21 87 D 1.00 171 0.396 H A -4 0.3 -0.69 ? ? ? ? ? ? ? 1 0 0 +32 PF00071.17 22.512 22.512 86.24 +P01112 87 T Q ? P01112 87 T Q ? ? benign alignment ? neutral 0.011 0.222 0.959 0.239 NO NO ? +0.744 -2.558 -3.302 2 238 20 20 6q21 87 D 1.00 171 0.396 H A 28 0.42 -0.69 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 13.809 13.809 86.24 +P01112 87 T R ? P01112 87 T R ? ? benign alignment ? neutral 0.001 0.852 0.994 0.514 NO NO ? -0.205 -2.558 -2.353 2 238 20 20 6q21 87 D 1.00 171 0.396 H A 57 0.98 -0.69 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 24.392 24.392 86.24 +P01112 87 T S ? P01112 87 T S C G benign alignment ? neutral 0 1 1 0.575 NO NO ? -0.012 -2.558 -2.546 2 238 20 20 6q21 87 D 1.00 171 0.396 H A -27 0.05 -0.69 ? ? ? ? ? ? ? 1 1 0 +31 PF00071.17 18.967 18.967 86.24 +P01112 87 T V ? P01112 87 T V ? ? benign alignment ? neutral 0.017 0.205 0.954 0.225 NO NO ? +0.968 -2.558 -3.526 2 238 20 20 6q21 87 D 1.00 171 0.396 H A 24 0.66 -0.69 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 14.644 ? 86.24 +P01112 87 T W ? P01112 87 T W ? ? probably damaging alignment ? deleterious 0.982 0.0393 0.748 0.0664 NO NO ? +2.855 -2.558 -5.413 2 238 20 20 6q21 87 D 1.00 171 0.396 H A 111 0.69 -0.69 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.949 ? 86.24 +P01112 87 T Y ? P01112 87 T Y ? ? benign alignment ? neutral 0.015 0.209 0.956 0.229 NO NO ? +0.794 -2.558 -3.352 2 238 20 20 6q21 87 D 1.00 171 0.396 H A 77 0.43 -0.69 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 22.503 22.503 86.24 +P01112 88 K A ? P01112 88 K A ? ? benign alignment ? neutral 0.163 0.132 0.92 0.162 NO NO ? +0.832 -1.782 -2.614 2 238 20 20 6q21 88 D 1.00 171 0.584 H A -80 2.34 -0.13 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 14.560 14.560 75.66 +P01112 88 K C ? P01112 88 K C ? ? probably damaging alignment ? deleterious 0.998 0.0112 0.273 0.0274 NO NO ? +3.403 -1.782 -5.185 2 238 20 20 6q21 88 D 1.00 171 0.584 H A -60 2.8 -0.13 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.215 ? 75.66 +P01112 88 K D ? P01112 88 K D ? ? possibly damaging alignment ? deleterious 0.917 0.0597 0.812 0.0907 NO NO ? +1.879 -1.782 -3.661 2 238 20 20 6q21 88 D 1.00 171 0.584 H A -57 1.59 -0.13 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 6.465 ? 75.66 +P01112 88 K E ? P01112 88 K E A G benign alignment ? neutral 0.01 0.226 0.96 0.242 NO NO ? +0.905 -1.782 -2.687 2 238 20 20 6q21 88 D 1.00 171 0.584 H A -30 1.3 -0.13 ? ? ? ? ? ? ? 0 0 2 +29 PF00071.17 21.219 21.219 75.66 +P01112 88 K F ? P01112 88 K F ? ? possibly damaging alignment ? deleterious 0.815 0.0708 0.84 0.102 NO NO ? +2.500 -1.782 -4.282 2 238 20 20 6q21 88 D 1.00 171 0.584 H A 22 2.92 -0.13 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 5.906 ? 75.66 +P01112 88 K G ? P01112 88 K G ? ? possibly damaging alignment ? deleterious 0.863 0.0664 0.83 0.0978 NO NO ? +1.742 -1.782 -3.524 2 238 20 20 6q21 88 D 1.00 171 0.584 H A -108 2.05 -0.13 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 4.467 ? 75.66 +P01112 88 K H ? P01112 88 K H ? ? benign alignment ? neutral 0.157 0.133 0.921 0.163 NO NO ? +1.083 -1.782 -2.865 2 238 20 20 6q21 88 D 1.00 171 0.584 H A -15 2.17 -0.13 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 16.297 16.297 75.66 +P01112 88 K I ? P01112 88 K I ? ? benign alignment ? neutral 0.245 0.119 0.912 0.151 NO NO ? +2.259 -1.782 -4.041 2 238 20 20 6q21 88 D 1.00 171 0.584 H A -1 2.82 -0.13 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 6.776 ? 75.66 +P01112 88 K L ? P01112 88 K L ? ? benign alignment ? neutral 0.085 0.151 0.932 0.18 NO NO ? +1.795 -1.782 -3.577 2 238 20 20 6q21 88 D 1.00 171 0.584 H A -1 2.89 -0.13 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 5.365 ? 75.66 +P01112 88 K M ? P01112 88 K M A T probably damaging alignment ? deleterious 0.979 0.0411 0.755 0.0687 NO NO ? +2.956 -1.782 -4.738 2 238 20 20 6q21 88 D 1.00 171 0.584 H A -5 2.89 -0.13 ? ? ? ? ? ? ? 1 1 0 +28 PF00071.17 1.520 ? 75.66 +P01112 88 K N ? P01112 88 K N G C benign alignment ? neutral 0.252 0.118 0.911 0.15 NO NO ? +1.264 -1.782 -3.046 2 238 20 20 6q21 88 D 1.00 171 0.584 H A -54 1.73 -0.13 ? ? ? ? ? ? ? 1 2 0 +27 PF00071.17 15.585 15.585 75.66 +P01112 88 K P ? P01112 88 K P ? ? benign alignment ? neutral 0.095 0.147 0.93 0.176 NO NO ? +1.089 -1.782 -2.871 2 238 20 20 6q21 88 D 1.00 171 0.584 H A -56 1.82 -0.13 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 35.076 35.076 75.66 +P01112 88 K Q ? P01112 88 K Q A C benign alignment ? neutral 0.018 0.202 0.953 0.223 NO NO ? +0.931 -1.782 -2.713 2 238 20 20 6q21 88 D 1.00 171 0.584 H A -24 1.7 -0.13 ? ? ? ? ? ? ? 1 0 0 +29 PF00071.17 15.054 15.054 75.66 +P01112 88 K R ? P01112 88 K R A G benign alignment ? neutral 0.006 0.253 0.967 0.262 NO NO ? +0.856 -1.782 -2.638 2 238 20 20 6q21 88 D 1.00 171 0.584 H A 5 1.14 -0.13 ? ? ? ? ? ? ? 0 1 0 +28 PF00071.17 26.031 26.031 75.66 +P01112 88 K S ? P01112 88 K S ? ? benign alignment ? neutral 0.163 0.132 0.92 0.162 NO NO ? +0.777 -1.782 -2.559 2 238 20 20 6q21 88 D 1.00 171 0.584 H A -79 2.07 -0.13 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 14.661 14.661 75.66 +P01112 88 K T ? P01112 88 K T A C benign alignment ? neutral 0.092 0.148 0.931 0.177 NO NO ? +1.194 -1.782 -2.976 2 238 20 20 6q21 88 D 1.00 171 0.584 H A -52 2.12 -0.13 ? ? ? ? ? ? ? 1 1 2 +28 PF00071.17 14.052 14.052 75.66 +P01112 88 K V ? P01112 88 K V ? ? benign alignment ? neutral 0.048 0.167 0.941 0.194 NO NO ? +1.267 -1.782 -3.049 2 238 20 20 6q21 88 D 1.00 171 0.584 H A -28 2.78 -0.13 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 11.111 11.111 75.66 +P01112 88 K W ? P01112 88 K W ? ? probably damaging alignment ? deleterious 0.999 0.00574 0.136 0.0192 NO NO ? +3.635 -1.782 -5.417 2 238 20 20 6q21 88 D 1.00 171 0.584 H A 59 2.81 -0.13 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.236 ? 75.66 +P01112 88 K Y ? P01112 88 K Y ? ? benign alignment ? neutral 0.02 0.198 0.952 0.22 NO NO ? +1.203 -1.782 -2.985 2 238 20 20 6q21 88 D 1.00 171 0.584 H A 25 2.55 -0.13 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 14.275 14.275 75.66 +P01112 89 S A ? P01112 89 S A T G possibly damaging alignment ? deleterious 0.704 0.082 0.859 0.115 NO NO ? +1.199 -1.186 -2.385 2 238 20 20 6q21 89 D 1.00 171 0.000 H A -1 0.27 -0.86 ? ? ? ? ? ? ? 1 0 0 +26 PF00071.17 20.690 20.690 71.43 +P01112 89 S C ? P01112 89 S C C G probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.604 -1.186 -4.790 2 238 20 20 6q21 89 D 1.00 171 0.000 H A 19 0.73 -0.86 ? ? ? ? ? ? ? 1 1 0 +25 PF00071.17 1.531 ? 71.43 +P01112 89 S D ? P01112 89 S D ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.269 -1.186 -3.455 2 238 20 20 6q21 89 D 1.00 171 0.000 H A 22 0.48 -0.86 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 4.502 ? 71.43 +P01112 89 S E ? P01112 89 S E ? ? probably damaging alignment ? deleterious 0.999 0.00574 0.136 0.0192 NO NO ? +1.504 -1.186 -2.690 2 238 20 20 6q21 89 D 1.00 171 0.000 H A 49 0.77 -0.86 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 14.774 14.774 71.43 +P01112 89 S F ? P01112 89 S F C T probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.926 -1.186 -4.112 2 238 20 20 6q21 89 D 1.00 171 0.000 H A 101 0.85 -0.86 ? ? ? ? ? ? ? 0 1 0 +25 PF00071.17 4.276 ? 71.43 +P01112 89 S G ? P01112 89 S G ? ? probably damaging alignment ? deleterious 0.999 0.00574 0.136 0.0192 NO NO ? +1.983 -1.186 -3.169 2 238 20 20 6q21 89 D 1.00 171 0.000 H A -29 0.02 -0.86 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 5.597 ? 71.43 +P01112 89 S H ? P01112 89 S H ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.451 -1.186 -4.637 2 238 20 20 6q21 89 D 1.00 171 0.000 H A 64 0.1 -0.86 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.252 ? 71.43 +P01112 89 S I ? P01112 89 S I ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.558 -1.186 -3.744 2 238 20 20 6q21 89 D 1.00 171 0.000 H A 78 0.75 -0.86 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 11.554 ? 71.43 +P01112 89 S K ? P01112 89 S K ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.251 -1.186 -3.437 2 238 20 20 6q21 89 D 1.00 171 0.000 H A 79 2.07 -0.86 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 3.784 ? 71.43 +P01112 89 S L ? P01112 89 S L ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.191 -1.186 -3.377 2 238 20 20 6q21 89 D 1.00 171 0.000 H A 78 0.82 -0.86 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 9.147 ? 71.43 +P01112 89 S M ? P01112 89 S M ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.385 -1.186 -4.571 2 238 20 20 6q21 89 D 1.00 171 0.000 H A 74 0.82 -0.86 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.232 ? 71.43 +P01112 89 S N ? P01112 89 S N ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.342 -1.186 -3.528 2 238 20 20 6q21 89 D 1.00 171 0.000 H A 25 0.34 -0.86 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.418 ? 71.43 +P01112 89 S P ? P01112 89 S P T C probably damaging alignment ? deleterious 0.999 0.00574 0.136 0.0192 NO NO ? +2.641 -1.186 -3.827 2 238 20 20 6q21 89 D 1.00 171 0.000 H A 23 0.25 -0.86 ? ? ? ? ? ? ? 0 0 0 +26 PF00071.17 2.076 ? 71.43 +P01112 89 S Q ? P01112 89 S Q ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.658 -1.186 -3.844 2 238 20 20 6q21 89 D 1.00 171 0.000 H A 55 0.37 -0.86 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 3.240 ? 71.43 +P01112 89 S R ? P01112 89 S R ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.677 -1.186 -3.863 2 238 20 20 6q21 89 D 1.00 171 0.000 H A 84 0.93 -0.86 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.466 ? 71.43 +P01112 89 S T ? P01112 89 S T T A possibly damaging alignment ? deleterious 0.597 0.0919 0.874 0.125 NO NO ? +1.177 -1.186 -2.363 2 238 20 20 6q21 89 D 1.00 171 0.000 H A 27 0.05 -0.86 ? ? ? ? ? ? ? 1 0 0 +26 PF00071.17 13.532 13.532 71.43 +P01112 89 S V ? P01112 89 S V ? ? probably damaging alignment ? deleterious 0.998 0.0112 0.273 0.0274 NO NO ? +1.558 -1.186 -2.744 2 238 20 20 6q21 89 D 1.00 171 0.000 H A 51 0.71 -0.86 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 18.946 18.946 71.43 +P01112 89 S W ? P01112 89 S W ? ? probably damaging structure 1.1.2 deleterious 0.992 0.0314 0.704 0.0568 NO NO ? +1.983 -1.186 -3.169 2 238 20 20 6q21 89 D 1.00 171 0.000 H A 138 0.74 -0.86 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 32.577 32.577 71.43 +P01112 89 S Y ? P01112 89 S Y C A probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.974 -1.186 -4.160 2 238 20 20 6q21 89 D 1.00 171 0.000 H A 104 0.48 -0.86 ? ? ? ? ? ? ? 1 1 0 +25 PF00071.17 4.468 ? 71.43 +P01112 90 F A ? P01112 90 F A ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.261 -1.054 -3.315 2 238 20 20 6q21 90 D 1.00 171 0.107 H A -102 0.58 -0.93 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 7.052 ? 73.54 +P01112 90 F C ? P01112 90 F C T G probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.872 -1.054 -4.926 2 238 20 20 6q21 90 D 1.00 171 0.107 H A -82 0.12 -0.93 ? ? ? ? ? ? ? 1 1 0 +22 PF00071.17 1.177 ? 73.54 +P01112 90 F D ? P01112 90 F D ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.926 -1.054 -3.980 2 238 20 20 6q21 90 D 1.00 171 0.107 H A -79 1.33 -0.93 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 3.162 ? 73.54 +P01112 90 F E ? P01112 90 F E ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.848 -1.054 -3.902 2 238 20 20 6q21 90 D 1.00 171 0.107 H A -52 1.62 -0.93 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 3.332 ? 73.54 +P01112 90 F G ? P01112 90 F G ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.591 -1.054 -3.645 2 238 20 20 6q21 90 D 1.00 171 0.107 H A -130 0.87 -0.93 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 4.325 ? 73.54 +P01112 90 F H ? P01112 90 F H ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.445 -1.054 -4.499 2 238 20 20 6q21 90 D 1.00 171 0.107 H A -37 0.75 -0.93 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 3.466 ? 73.54 +P01112 90 F I ? P01112 90 F I T A probably damaging alignment ? deleterious 0.999 0.00574 0.136 0.0192 NO NO ? +2.378 -1.054 -3.432 2 238 20 20 6q21 90 D 1.00 171 0.107 H A -23 0.1 -0.93 ? ? ? ? ? ? ? 1 0 0 +23 PF00071.17 8.098 ? 73.54 +P01112 90 F K ? P01112 90 F K ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.839 -1.054 -3.893 2 238 20 20 6q21 90 D 1.00 171 0.107 H A -22 2.92 -0.93 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 3.498 ? 73.54 +P01112 90 F L ? P01112 90 F L T C possibly damaging alignment ? deleterious 0.939 0.0562 0.8 0.0869 NO NO ? +1.239 -1.054 -2.293 2 238 20 20 6q21 90 D 1.00 171 0.107 H A -23 0.03 -0.93 ? ? ? ? ? ? ? 0 0 0 +23 PF00071.17 26.425 26.425 73.54 +P01112 90 F M ? P01112 90 F M ? ? probably damaging alignment ? deleterious 0.999 0.00574 0.136 0.0192 NO NO ? +3.286 -1.054 -4.340 2 238 20 20 6q21 90 D 1.00 171 0.107 H A -27 0.03 -0.93 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 3.507 ? 73.54 +P01112 90 F N ? P01112 90 F N ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.047 -1.054 -4.101 2 238 20 20 6q21 90 D 1.00 171 0.107 H A -76 1.19 -0.93 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 3.549 ? 73.54 +P01112 90 F P ? P01112 90 F P ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.262 -1.054 -4.316 2 238 20 20 6q21 90 D 1.00 171 0.107 H A -78 1.1 -0.93 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.879 ? 73.54 +P01112 90 F Q ? P01112 90 F Q ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.250 -1.054 -4.304 2 238 20 20 6q21 90 D 1.00 171 0.107 H A -46 1.22 -0.93 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.135 ? 73.54 +P01112 90 F R ? P01112 90 F R ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.118 -1.054 -4.172 2 238 20 20 6q21 90 D 1.00 171 0.107 H A -17 1.78 -0.93 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.556 ? 73.54 +P01112 90 F S ? P01112 90 F S T C probably damaging alignment ? deleterious 0.997 0.0167 0.409 0.0357 NO NO ? +1.752 -1.054 -2.806 2 238 20 20 6q21 90 D 1.00 171 0.107 H A -101 0.85 -0.93 ? ? ? ? ? ? ? 0 1 0 +22 PF00071.17 14.196 14.196 73.54 +P01112 90 F T ? P01112 90 F T ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.605 -1.054 -3.659 2 238 20 20 6q21 90 D 1.00 171 0.107 H A -74 0.8 -0.93 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 5.302 ? 73.54 +P01112 90 F V ? P01112 90 F V T G probably damaging alignment ? deleterious 0.999 0.00574 0.136 0.0192 NO NO ? +2.312 -1.054 -3.366 2 238 20 20 6q21 90 D 1.00 171 0.107 H A -50 0.14 -0.93 ? ? ? ? ? ? ? 1 0 0 +23 PF00071.17 6.744 ? 73.54 +P01112 90 F W ? P01112 90 F W ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.557 -1.054 -4.611 2 238 20 20 6q21 90 D 1.00 171 0.107 H A 37 0.11 -0.93 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.022 ? 73.54 +P01112 90 F Y ? P01112 90 F Y T A possibly damaging alignment ? deleterious 0.872 0.0655 0.827 0.0969 NO NO ? +1.340 -1.054 -2.394 2 238 20 20 6q21 90 D 1.00 171 0.107 H A 3 0.37 -0.93 ? ? ? ? ? ? ? 1 1 0 +22 PF00071.17 23.343 23.343 73.54 +P01112 91 E A ? P01112 91 E A A C benign alignment ? neutral 0.007 0.246 0.965 0.257 NO NO ? +0.821 -1.498 -2.319 2 238 20 20 6q21 91 D 1.00 171 0.583 H A -50 1.04 -0.27 ? ? ? ? ? ? ? 1 1 2 +19 PF00071.17 24.981 24.981 86.24 +P01112 91 E C ? P01112 91 E C ? ? probably damaging alignment ? deleterious 0.97 0.0446 0.769 0.0728 NO NO ? +3.690 -1.498 -5.188 2 238 20 20 6q21 91 D 1.00 171 0.583 H A -30 1.5 -0.27 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.848 ? 86.24 +P01112 91 E D ? P01112 91 E D G C benign alignment ? neutral 0 1 1 0.575 NO NO ? +0.696 -1.498 -2.194 2 238 20 20 6q21 91 D 1.00 171 0.583 H A -27 0.29 -0.27 ? ? ? ? ? ? ? 1 2 2 +18 PF00071.17 29.177 29.177 86.24 +P01112 91 E F ? P01112 91 E F ? ? probably damaging alignment ? deleterious 0.984 0.0381 0.743 0.065 NO NO ? +2.902 -1.498 -4.400 2 238 20 20 6q21 91 D 1.00 171 0.583 H A 52 1.62 -0.27 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.524 ? 86.24 +P01112 91 E G ? P01112 91 E G A G benign alignment ? neutral 0.048 0.167 0.941 0.194 NO NO ? +1.234 -1.498 -2.732 2 238 20 20 6q21 91 D 1.00 171 0.583 H A -78 0.75 -0.27 ? ? ? ? ? ? ? 0 1 0 +19 PF00071.17 33.451 33.451 86.24 +P01112 91 E H ? P01112 91 E H ? ? probably damaging alignment ? deleterious 0.977 0.0424 0.758 0.0704 NO NO ? +3.079 -1.498 -4.577 2 238 20 20 6q21 91 D 1.00 171 0.583 H A 15 0.87 -0.27 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.911 ? 86.24 +P01112 91 E I ? P01112 91 E I ? ? possibly damaging alignment ? deleterious 0.65 0.0878 0.866 0.121 NO NO ? +2.433 -1.498 -3.931 2 238 20 20 6q21 91 D 1.00 171 0.583 H A 29 1.52 -0.27 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 11.728 ? 86.24 +P01112 91 E K ? P01112 91 E K G A benign alignment ? neutral 0.108 0.143 0.928 0.173 NO NO ? +1.051 -1.498 -2.549 2 238 20 20 6q21 91 D 1.00 171 0.583 H A 30 1.3 -0.27 ? ? ? ? ? ? ? 0 0 0 +20 PF00071.17 14.953 14.953 86.24 +P01112 91 E L ? P01112 91 E L ? ? possibly damaging alignment ? deleterious 0.65 0.0878 0.866 0.121 NO NO ? +2.079 -1.498 -3.577 2 238 20 20 6q21 91 D 1.00 171 0.583 H A 29 1.59 -0.27 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 9.285 ? 86.24 +P01112 91 E M ? P01112 91 E M ? ? possibly damaging alignment ? deleterious 0.835 0.0687 0.836 0.1 NO NO ? +3.245 -1.498 -4.743 2 238 20 20 6q21 91 D 1.00 171 0.583 H A 25 1.59 -0.27 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.265 ? 86.24 +P01112 91 E N ? P01112 91 E N ? ? possibly damaging alignment ? neutral 0.463 0.0994 0.888 0.132 NO NO ? +2.182 -1.498 -3.680 2 238 20 20 6q21 91 D 1.00 171 0.583 H A -24 0.43 -0.27 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 5.102 ? 86.24 +P01112 91 E P ? P01112 91 E P ? ? possibly damaging alignment ? deleterious 0.528 0.0956 0.881 0.128 NO NO ? +2.381 -1.498 -3.879 2 238 20 20 6q21 91 D 1.00 171 0.583 H A -26 0.52 -0.27 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.506 ? 86.24 +P01112 91 E Q ? P01112 91 E Q G C benign alignment ? neutral 0.08 0.154 0.933 0.182 NO NO ? +1.213 -1.498 -2.711 2 238 20 20 6q21 91 D 1.00 171 0.583 H A 6 0.4 -0.27 ? ? ? ? ? ? ? 1 0 0 +20 PF00071.17 13.357 13.357 86.24 +P01112 91 E R ? P01112 91 E R ? ? benign alignment ? neutral 0.083 0.152 0.933 0.181 NO NO ? +1.455 -1.498 -2.953 2 238 20 20 6q21 91 D 1.00 171 0.583 H A 35 0.16 -0.27 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 24.210 24.210 86.24 +P01112 91 E S ? P01112 91 E S ? ? possibly damaging alignment ? deleterious 0.681 0.0843 0.862 0.117 NO NO ? +1.860 -1.498 -3.358 2 238 20 20 6q21 91 D 1.00 171 0.583 H A -49 0.77 -0.27 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 7.266 ? 86.24 +P01112 91 E T ? P01112 91 E T ? ? possibly damaging alignment ? deleterious 0.855 0.0671 0.832 0.0986 NO NO ? +2.068 -1.498 -3.566 2 238 20 20 6q21 91 D 1.00 171 0.583 H A -22 0.82 -0.27 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 4.321 ? 86.24 +P01112 91 E V ? P01112 91 E V A T benign alignment ? neutral 0.009 0.233 0.961 0.247 NO NO ? +1.180 -1.498 -2.678 2 238 20 20 6q21 91 D 1.00 171 0.583 H A 2 1.48 -0.27 ? ? ? ? ? ? ? 1 1 0 +19 PF00071.17 19.231 19.231 86.24 +P01112 91 E W ? P01112 91 E W ? ? probably damaging alignment ? deleterious 0.998 0.0112 0.273 0.0274 NO NO ? +4.000 -1.498 -5.498 2 238 20 20 6q21 91 D 1.00 171 0.583 H A 89 1.51 -0.27 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 0.468 ? 86.24 +P01112 91 E Y ? P01112 91 E Y ? ? probably damaging alignment ? deleterious 0.998 0.0112 0.273 0.0274 NO NO ? +2.845 -1.498 -4.343 2 238 20 20 6q21 91 D 1.00 171 0.583 H A 55 1.25 -0.27 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.517 ? 86.24 +P01112 92 D A ? P01112 92 D A A C benign alignment ? neutral 0.01 0.226 0.96 0.242 NO NO ? +0.702 -1.798 -2.500 2 237 20 20 6q21 92 D 1.00 171 0.152 H A -23 0.75 0.14 ? ? ? ? ? ? ? 1 1 0 +16 PF00071.17 23.142 23.142 79.89 +P01112 92 D C ? P01112 92 D C ? ? probably damaging alignment ? deleterious 0.971 0.0444 0.768 0.0727 NO NO ? +3.386 -1.798 -5.184 2 237 20 20 6q21 92 D 1.00 171 0.152 H A -3 1.21 0.14 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.712 ? 79.89 +P01112 92 D E ? P01112 92 D E C G benign alignment ? neutral 0 1 1 0.575 NO NO ? +0.245 -1.798 -2.043 2 237 20 20 6q21 92 D 1.00 171 0.152 H A 27 0.29 0.14 ? ? ? ? ? ? ? 1 2 0 +15 PF00071.17 22.476 22.476 79.89 +P01112 92 D F ? P01112 92 D F ? ? probably damaging alignment ? deleterious 0.991 0.0326 0.711 0.0584 NO NO ? +2.584 -1.798 -4.382 2 237 20 20 6q21 92 D 1.00 171 0.152 H A 79 1.33 0.14 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.299 ? 79.89 +P01112 92 D G ? P01112 92 D G A G benign alignment ? neutral 0.007 0.246 0.965 0.257 NO NO ? +0.644 -1.798 -2.442 2 237 20 20 6q21 92 D 1.00 171 0.152 H A -51 0.46 0.14 ? ? ? ? ? ? ? 0 1 0 +16 PF00071.17 35.879 35.879 79.89 +P01112 92 D H ? P01112 92 D H G C benign alignment ? neutral 0.429 0.102 0.892 0.135 NO NO ? +1.415 -1.798 -3.213 2 237 20 20 6q21 92 D 1.00 171 0.152 H A 42 0.58 0.14 ? ? ? ? ? ? ? 1 0 0 +17 PF00071.17 17.233 17.233 79.89 +P01112 92 D I ? P01112 92 D I ? ? probably damaging alignment ? deleterious 0.965 0.047 0.776 0.0757 NO NO ? +2.205 -1.798 -4.003 2 237 20 20 6q21 92 D 1.00 171 0.152 H A 56 1.23 0.14 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 10.685 ? 79.89 +P01112 92 D K ? P01112 92 D K ? ? possibly damaging alignment ? deleterious 0.583 0.0933 0.875 0.126 NO NO ? +0.792 -1.798 -2.590 2 237 20 20 6q21 92 D 1.00 171 0.152 H A 57 1.59 0.14 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 12.314 12.314 79.89 +P01112 92 D L ? P01112 92 D L ? ? probably damaging alignment ? deleterious 0.965 0.047 0.776 0.0757 NO NO ? +1.874 -1.798 -3.672 2 237 20 20 6q21 92 D 1.00 171 0.152 H A 56 1.3 0.14 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 8.460 ? 79.89 +P01112 92 D M ? P01112 92 D M ? ? probably damaging alignment ? deleterious 0.994 0.0289 0.689 0.0537 NO NO ? +3.050 -1.798 -4.848 2 237 20 20 6q21 92 D 1.00 171 0.152 H A 52 1.3 0.14 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.064 ? 79.89 +P01112 92 D N ? P01112 92 D N G A benign alignment ? neutral 0.002 0.704 0.987 0.452 NO NO ? +0.313 -1.798 -2.111 2 237 20 20 6q21 92 D 1.00 171 0.152 H A 3 0.14 0.14 ? ? ? ? ? ? ? 0 0 0 +17 PF00071.17 24.299 24.299 79.89 +P01112 92 D P ? P01112 92 D P ? ? possibly damaging alignment ? deleterious 0.685 0.0836 0.861 0.116 NO NO ? +2.115 -1.798 -3.913 2 237 20 20 6q21 92 D 1.00 171 0.152 H A 1 0.23 0.14 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.322 ? 79.89 +P01112 92 D Q ? P01112 92 D Q ? ? possibly damaging alignment ? deleterious 0.91 0.0609 0.814 0.092 NO NO ? +1.999 -1.798 -3.797 2 237 20 20 6q21 92 D 1.00 171 0.152 H A 33 0.11 0.14 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 4.930 ? 79.89 +P01112 92 D R ? P01112 92 D R ? ? probably damaging alignment ? deleterious 0.965 0.047 0.776 0.0757 NO NO ? +1.988 -1.798 -3.786 2 237 20 20 6q21 92 D 1.00 171 0.152 H A 62 0.45 0.14 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 4.764 ? 79.89 +P01112 92 D S ? P01112 92 D S ? ? possibly damaging alignment ? deleterious 0.684 0.0838 0.862 0.116 NO NO ? +1.504 -1.798 -3.302 2 237 20 20 6q21 92 D 1.00 171 0.152 H A -22 0.48 0.14 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 6.731 ? 79.89 +P01112 92 D T ? P01112 92 D T ? ? possibly damaging alignment ? deleterious 0.658 0.0867 0.865 0.12 NO NO ? +1.747 -1.798 -3.545 2 237 20 20 6q21 92 D 1.00 171 0.152 H A 5 0.53 0.14 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 4.003 ? 79.89 +P01112 92 D V ? P01112 92 D V A T benign alignment ? neutral 0.127 0.14 0.925 0.17 NO NO ? +1.141 -1.798 -2.939 2 237 20 20 6q21 92 D 1.00 171 0.152 H A 29 1.19 0.14 ? ? ? ? ? ? ? 1 1 0 +16 PF00071.17 17.521 17.521 79.89 +P01112 92 D W ? P01112 92 D W ? ? probably damaging alignment ? deleterious 0.999 0.00574 0.136 0.0192 NO NO ? +3.752 -1.798 -5.550 2 237 20 20 6q21 92 D 1.00 171 0.152 H A 116 1.22 0.14 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 0.434 ? 79.89 +P01112 92 D Y ? P01112 92 D Y G T probably damaging alignment ? deleterious 0.976 0.043 0.76 0.0712 NO NO ? +2.508 -1.798 -4.306 2 237 20 20 6q21 92 D 1.00 171 0.152 H A 82 0.96 0.14 ? ? ? ? ? ? ? 1 0 0 +17 PF00071.17 2.825 ? 79.89 +P01112 93 I A ? P01112 93 I A ? ? possibly damaging alignment ? deleterious 0.948 0.0532 0.793 0.0833 NO NO ? +1.594 -1.549 -3.143 2 237 20 20 6q21 93 D 1.00 171 0.023 H A -79 0.48 -0.42 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 5.810 ? 83.60 +P01112 93 I C ? P01112 93 I C ? ? possibly damaging alignment ? deleterious 0.594 0.0921 0.874 0.125 NO NO ? +1.682 -1.549 -3.231 2 237 20 20 6q21 93 D 1.00 171 0.023 H A -59 0.02 -0.42 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 21.480 21.480 83.60 +P01112 93 I D ? P01112 93 I D ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.472 -1.549 -4.021 2 237 20 20 6q21 93 D 1.00 171 0.023 H A -56 1.23 -0.42 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.561 ? 83.60 +P01112 93 I E ? P01112 93 I E ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.335 -1.549 -3.884 2 237 20 20 6q21 93 D 1.00 171 0.023 H A -29 1.52 -0.42 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 3.669 ? 83.60 +P01112 93 I F ? P01112 93 I F A T probably damaging alignment ? deleterious 0.99 0.0338 0.719 0.06 NO NO ? +2.358 -1.549 -3.907 2 237 20 20 6q21 93 D 1.00 171 0.023 H A 23 0.1 -0.42 ? ? ? ? ? ? ? 1 0 0 +14 PF00071.17 3.402 ? 83.60 +P01112 93 I G ? P01112 93 I G ? ? probably damaging alignment ? deleterious 0.996 0.0222 0.545 0.0439 NO NO ? +2.250 -1.549 -3.799 2 237 20 20 6q21 93 D 1.00 171 0.023 H A -107 0.77 -0.42 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.572 ? 83.60 +P01112 93 I H ? P01112 93 I H ? ? benign alignment ? neutral 0.378 0.107 0.897 0.139 NO NO ? +1.724 -1.549 -3.273 2 237 20 20 6q21 93 D 1.00 171 0.023 H A -14 0.65 -0.42 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 24.913 24.913 83.60 +P01112 93 I K ? P01112 93 I K ? ? probably damaging alignment ? deleterious 0.991 0.0326 0.711 0.0584 NO NO ? +2.332 -1.549 -3.881 2 237 20 20 6q21 93 D 1.00 171 0.023 H A 1 2.82 -0.42 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 3.188 ? 83.60 +P01112 93 I L ? P01112 93 I L A C benign alignment ? neutral 0.001 0.852 0.994 0.514 NO NO ? +0.856 -1.549 -2.405 2 237 20 20 6q21 93 D 1.00 171 0.023 H A 0 0.07 -0.42 ? ? ? ? ? ? ? 1 0 0 +14 PF00071.17 22.054 22.054 83.60 +P01112 93 I M ? P01112 93 I M C G benign alignment ? neutral 0.21 0.123 0.915 0.154 NO NO ? +1.606 -1.549 -3.155 2 237 20 20 6q21 93 D 1.00 171 0.023 H A -4 0.07 -0.42 ? ? ? ? ? ? ? 1 2 0 +12 PF00071.17 11.569 11.569 83.60 +P01112 93 I N ? P01112 93 I N T A probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.577 -1.549 -4.126 2 237 20 20 6q21 93 D 1.00 171 0.023 H A -53 1.09 -0.42 ? ? ? ? ? ? ? 1 1 0 +13 PF00071.17 3.839 ? 83.60 +P01112 93 I P ? P01112 93 I P ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.578 -1.549 -4.127 2 237 20 20 6q21 93 D 1.00 171 0.023 H A -55 1 -0.42 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.427 ? 83.60 +P01112 93 I Q ? P01112 93 I Q ? ? probably damaging alignment ? deleterious 0.999 0.00574 0.136 0.0192 NO NO ? +2.734 -1.549 -4.283 2 237 20 20 6q21 93 D 1.00 171 0.023 H A -23 1.12 -0.42 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.816 ? 83.60 +P01112 93 I R ? P01112 93 I R ? ? probably damaging alignment ? deleterious 0.999 0.00574 0.136 0.0192 NO NO ? +2.630 -1.549 -4.179 2 237 20 20 6q21 93 D 1.00 171 0.023 H A 6 1.68 -0.42 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 3.331 ? 83.60 +P01112 93 I S ? P01112 93 I S T G probably damaging alignment ? deleterious 0.99 0.0338 0.719 0.06 NO NO ? +2.118 -1.549 -3.667 2 237 20 20 6q21 93 D 1.00 171 0.023 H A -78 0.75 -0.42 ? ? ? ? ? ? ? 1 1 0 +13 PF00071.17 3.812 ? 83.60 +P01112 93 I T ? P01112 93 I T T C possibly damaging alignment ? deleterious 0.63 0.0891 0.868 0.122 NO NO ? +1.235 -1.549 -2.784 2 237 20 20 6q21 93 D 1.00 171 0.023 H A -51 0.7 -0.42 ? ? ? ? ? ? ? 0 1 0 +13 PF00071.17 10.149 10.149 83.60 +P01112 93 I V ? P01112 93 I V A G benign alignment ? neutral 0.001 0.852 0.994 0.514 NO NO ? +0.032 -1.549 -1.581 2 237 20 20 6q21 93 D 1.00 171 0.023 H A -27 0.04 -0.42 ? ? ? ? ? ? ? 0 0 2 +14 PF00071.17 22.507 22.507 83.60 +P01112 93 I W ? P01112 93 I W ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.838 -1.549 -5.387 2 237 20 20 6q21 93 D 1.00 171 0.023 H A 60 0.01 -0.42 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 0.568 ? 83.60 +P01112 93 I Y ? P01112 93 I Y ? ? possibly damaging alignment ? deleterious 0.856 0.067 0.832 0.0984 NO NO ? +2.513 -1.549 -4.062 2 237 20 20 6q21 93 D 1.00 171 0.023 H A 26 0.27 -0.42 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 4.084 ? 83.60 +P01112 94 H A ? P01112 94 H A ? ? benign alignment ? neutral 0 1 1 0.575 NO NO ? -0.028 -2.503 -2.475 2 237 20 20 6q21 94 D 1.00 171 0.635 H A -65 0.17 0.10 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 22.836 22.836 86.24 +P01112 94 H C ? P01112 94 H C ? ? benign alignment ? neutral 0.369 0.108 0.898 0.14 NO NO ? +2.630 -2.503 -5.133 2 237 20 20 6q21 94 D 1.00 171 0.635 H A -45 0.63 0.10 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.689 ? 86.24 +P01112 94 H D ? P01112 94 H D C G benign alignment ? neutral 0 1 1 0.575 NO NO ? +0.235 -2.503 -2.738 2 237 20 20 6q21 94 D 1.00 171 0.635 H A -42 0.58 0.10 ? ? ? ? ? ? ? 1 0 2 +11 PF00071.17 28.967 28.967 86.24 +P01112 94 H E ? P01112 94 H E ? ? benign alignment ? neutral 0 1 1 0.575 NO NO ? +0.450 -2.503 -2.953 2 237 20 20 6q21 94 D 1.00 171 0.635 H A -15 0.87 0.10 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 21.376 21.376 86.24 +P01112 94 H F ? P01112 94 H F ? ? benign alignment ? neutral 0.071 0.156 0.935 0.185 NO NO ? +1.783 -2.503 -4.286 2 237 20 20 6q21 94 D 1.00 171 0.635 H A 37 0.75 0.10 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 10.214 ? 86.24 +P01112 94 H G ? P01112 94 H G ? ? benign alignment ? neutral 0 1 1 0.575 NO NO ? +0.112 -2.503 -2.615 2 237 20 20 6q21 94 D 1.00 171 0.635 H A -93 0.12 0.10 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 39.656 39.656 86.24 +P01112 94 H I ? P01112 94 H I ? ? benign alignment ? neutral 0.001 0.852 0.994 0.514 NO NO ? +0.741 -2.503 -3.244 2 237 20 20 6q21 94 D 1.00 171 0.635 H A 14 0.65 0.10 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 19.395 19.395 86.24 +P01112 94 H K ? P01112 94 H K ? ? benign alignment ? neutral 0.022 0.195 0.951 0.217 NO NO ? +1.138 -2.503 -3.641 2 237 20 20 6q21 94 D 1.00 171 0.635 H A 15 2.17 0.10 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 5.475 ? 86.24 +P01112 94 H L ? P01112 94 H L A T benign alignment ? neutral 0.017 0.205 0.954 0.225 NO NO ? +1.138 -2.503 -3.641 2 237 20 20 6q21 94 D 1.00 171 0.635 H A 14 0.72 0.10 ? ? ? ? ? ? ? 1 1 0 +10 PF00071.17 11.971 ? 86.24 +P01112 94 H M ? P01112 94 H M ? ? benign alignment ? neutral 0.276 0.116 0.908 0.147 NO NO ? +2.360 -2.503 -4.863 2 237 20 20 6q21 94 D 1.00 171 0.635 H A 10 0.72 0.10 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.638 ? 86.24 +P01112 94 H N ? P01112 94 H N C A benign alignment ? neutral 0 1 1 0.575 NO NO ? -0.556 -2.503 -1.947 2 237 20 20 6q21 94 D 1.00 171 0.635 H A -39 0.44 0.10 ? ? ? ? ? ? ? 1 0 0 +11 PF00071.17 27.315 27.315 86.24 +P01112 94 H P ? P01112 94 H P A C benign alignment ? neutral 0 1 1 0.575 NO NO ? +0.188 -2.503 -2.691 2 237 20 20 6q21 94 D 1.00 171 0.635 H A -41 0.35 0.10 ? ? ? ? ? ? ? 1 1 0 +10 PF00071.17 34.815 34.815 86.24 +P01112 94 H Q ? P01112 94 H Q C G benign alignment ? neutral 0.041 0.172 0.943 0.199 NO NO ? +1.512 -2.503 -4.015 2 237 20 20 6q21 94 D 1.00 171 0.635 H A -9 0.47 0.10 ? ? ? ? ? ? ? 1 2 0 +9 PF00071.17 4.688 ? 86.24 +P01112 94 H R ? P01112 94 H R A G benign alignment ? neutral 0.076 0.155 0.934 0.183 NO NO ? +1.431 -2.503 -3.934 2 237 20 20 6q21 94 D 1.00 171 0.635 H A 20 1.03 0.10 ? ? ? ? ? ? ? 0 1 2 +10 PF00071.17 3.822 ? 86.24 +P01112 94 H S ? P01112 94 H S ? ? benign alignment ? neutral 0.001 0.852 0.994 0.514 NO NO ? -0.240 -2.503 -2.263 2 237 20 20 6q21 94 D 1.00 171 0.635 H A -64 0.1 0.10 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 17.571 17.571 86.24 +P01112 94 H T ? P01112 94 H T ? ? benign alignment ? neutral 0 1 1 0.575 NO NO ? +0.081 -2.503 -2.584 2 237 20 20 6q21 94 D 1.00 171 0.635 H A -37 0.05 0.10 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 18.606 18.606 86.24 +P01112 94 H V ? P01112 94 H V ? ? benign alignment ? neutral 0.023 0.193 0.95 0.216 NO NO ? +1.185 -2.503 -3.688 2 237 20 20 6q21 94 D 1.00 171 0.635 H A -13 0.61 0.10 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 12.592 ? 86.24 +P01112 94 H W ? P01112 94 H W ? ? possibly damaging alignment ? deleterious 0.916 0.0599 0.812 0.0909 NO NO ? +2.992 -2.503 -5.495 2 237 20 20 6q21 94 D 1.00 171 0.635 H A 74 0.64 0.10 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.138 ? 86.24 +P01112 94 H Y ? P01112 94 H Y C T benign alignment ? neutral 0.001 0.852 0.994 0.514 NO NO ? +0.765 -2.503 -3.268 2 237 20 20 6q21 94 D 1.00 171 0.635 H A 40 0.38 0.10 ? ? ? ? ? ? ? 0 0 0 +11 PF00071.17 24.687 24.687 86.24 +P01112 95 Q A ? P01112 95 Q A ? ? benign alignment ? neutral 0 1 1 0.575 NO NO ? -0.324 -2.917 -2.593 2 237 20 20 6q21 95 D 1.00 171 0.436 H A -56 0.64 -0.06 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 24.368 24.368 86.24 +P01112 95 Q C ? P01112 95 Q C ? ? possibly damaging alignment ? neutral 0.464 0.0994 0.888 0.132 NO NO ? +2.211 -2.917 -5.128 2 237 20 20 6q21 95 D 1.00 171 0.436 H A -36 1.1 -0.06 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.803 ? 86.24 +P01112 95 Q D ? P01112 95 Q D ? ? benign alignment ? neutral 0 1 1 0.575 NO NO ? +0.245 -2.917 -3.162 2 237 20 20 6q21 95 D 1.00 171 0.436 H A -33 0.11 -0.06 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 21.830 21.830 86.24 +P01112 95 Q E ? P01112 95 Q E C G benign alignment ? neutral 0 1 1 0.575 NO NO ? -0.020 -2.917 -2.897 2 237 20 20 6q21 95 D 1.00 171 0.436 H A -6 0.4 -0.06 ? ? ? ? ? ? ? 1 0 2 +8 PF00071.17 15.089 15.089 86.24 +P01112 95 Q F ? P01112 95 Q F ? ? benign alignment ? neutral 0 1 1 0.575 NO NO ? +0.009 -2.917 -2.926 2 237 20 20 6q21 95 D 1.00 171 0.436 H A 46 1.22 -0.06 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 25.085 25.085 86.24 +P01112 95 Q G ? P01112 95 Q G ? ? benign alignment ? neutral 0.035 0.177 0.945 0.202 NO NO ? +0.727 -2.917 -3.644 2 237 20 20 6q21 95 D 1.00 171 0.436 H A -84 0.35 -0.06 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 6.592 ? 86.24 +P01112 95 Q H ? P01112 95 Q H G C benign alignment ? neutral 0 1 1 0.575 NO NO ? +0.135 -2.917 -3.052 2 237 20 20 6q21 95 D 1.00 171 0.436 H A 9 0.47 -0.06 ? ? ? ? ? ? ? 1 2 0 +6 PF00071.17 30.346 30.346 86.24 +P01112 95 Q I ? P01112 95 Q I ? ? benign alignment ? neutral 0 1 1 0.575 NO NO ? -0.106 -2.917 -2.811 2 237 20 20 6q21 95 D 1.00 171 0.436 H A 23 1.12 -0.06 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 19.970 19.970 86.24 +P01112 95 Q K ? P01112 95 Q K C A benign alignment ? neutral 0 1 1 0.575 NO NO ? +0.004 -2.917 -2.921 2 237 20 20 6q21 95 D 1.00 171 0.436 H A 24 1.7 -0.06 ? ? ? ? ? ? ? 1 0 0 +8 PF00071.17 19.791 19.791 86.24 +P01112 95 Q L ? P01112 95 Q L A T benign alignment ? neutral 0 1 1 0.575 NO NO ? -0.287 -2.917 -2.630 2 237 20 20 6q21 95 D 1.00 171 0.436 H A 23 1.19 -0.06 ? ? ? ? ? ? ? 1 1 0 +7 PF00071.17 32.386 32.386 86.24 +P01112 95 Q M ? P01112 95 Q M ? ? benign alignment ? neutral 0.006 0.253 0.967 0.262 NO NO ? +0.668 -2.917 -3.585 2 237 20 20 6q21 95 D 1.00 171 0.436 H A 19 1.19 -0.06 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 12.941 12.941 86.24 +P01112 95 Q N ? P01112 95 Q N ? ? benign alignment ? neutral 0 1 1 0.575 NO NO ? +0.096 -2.917 -3.013 2 237 20 20 6q21 95 D 1.00 171 0.436 H A -30 0.0299999999999999 -0.06 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 24.466 24.466 86.24 +P01112 95 Q P ? P01112 95 Q P A C benign alignment ? neutral 0 1 1 0.575 NO NO ? +0.134 -2.917 -3.051 2 237 20 20 6q21 95 D 1.00 171 0.436 H A -32 0.12 -0.06 ? ? ? ? ? ? ? 1 1 2 +7 PF00071.17 35.076 35.076 86.24 +P01112 95 Q R ? P01112 95 Q R A G benign alignment ? neutral 0.001 0.852 0.994 0.514 NO NO ? +0.368 -2.917 -3.285 2 237 20 20 6q21 95 D 1.00 171 0.436 H A 29 0.56 -0.06 ? ? ? ? ? ? ? 0 1 2 +7 PF00071.17 18.567 18.567 86.24 +P01112 95 Q S ? P01112 95 Q S ? ? benign alignment ? neutral 0.001 0.852 0.994 0.514 NO NO ? -0.332 -2.917 -2.585 2 237 20 20 6q21 95 D 1.00 171 0.436 H A -55 0.37 -0.06 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 16.756 16.756 86.24 +P01112 95 Q T ? P01112 95 Q T ? ? benign alignment ? neutral 0 1 1 0.575 NO NO ? -0.187 -2.917 -2.730 2 237 20 20 6q21 95 D 1.00 171 0.436 H A -28 0.42 -0.06 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 19.127 19.127 86.24 +P01112 95 Q V ? P01112 95 Q V ? ? benign alignment ? neutral 0 1 1 0.575 NO NO ? -0.356 -2.917 -2.561 2 237 20 20 6q21 95 D 1.00 171 0.436 H A -4 1.08 -0.06 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 15.384 15.384 86.24 +P01112 95 Q W ? P01112 95 Q W ? ? possibly damaging alignment ? deleterious 0.811 0.071 0.841 0.103 NO NO ? +2.511 -2.917 -5.428 2 237 20 20 6q21 95 D 1.00 171 0.436 H A 83 1.11 -0.06 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.255 ? 86.24 +P01112 95 Q Y ? P01112 95 Q Y ? ? benign alignment ? neutral 0.001 0.852 0.994 0.514 NO NO ? +0.435 -2.917 -3.352 2 237 20 20 6q21 95 D 1.00 171 0.436 H A 49 0.85 -0.06 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 26.030 26.030 86.24 +P01112 96 Y A ? P01112 96 Y A ? ? probably damaging structure 1.1.3 deleterious 0.966 0.0465 0.775 0.0751 NO NO ? +1.680 -1.636 -3.316 2 238 20 20 6q21 96 D 1.00 171 0.006 H A -105 0.21 -0.64 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 4.891 ? 70.90 +P01112 96 Y C ? P01112 96 Y C A G probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.278 -1.636 -4.914 2 238 20 20 6q21 96 D 1.00 171 0.006 H A -85 0.25 -0.64 ? ? ? ? ? ? ? 0 1 0 +4 PF00071.17 1.313 ? 70.90 +P01112 96 Y D ? P01112 96 Y D T G probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.460 -1.636 -4.096 2 238 20 20 6q21 96 D 1.00 171 0.006 H A -82 0.96 -0.64 ? ? ? ? ? ? ? 1 0 0 +5 PF00071.17 1.270 ? 70.90 +P01112 96 Y E ? P01112 96 Y E ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.283 -1.636 -3.919 2 238 20 20 6q21 96 D 1.00 171 0.006 H A -55 1.25 -0.64 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.639 ? 70.90 +P01112 96 Y F ? P01112 96 Y F A T benign alignment ? neutral 0.017 0.205 0.954 0.225 NO NO ? +0.145 -1.636 -1.781 2 238 20 20 6q21 96 D 1.00 171 0.006 H A -3 0.37 -0.64 ? ? ? ? ? ? ? 1 1 0 +4 PF00071.17 27.329 27.329 70.90 +P01112 96 Y G ? P01112 96 Y G ? ? probably damaging alignment ? deleterious 0.998 0.0112 0.273 0.0274 NO NO ? +2.139 -1.636 -3.775 2 238 20 20 6q21 96 D 1.00 171 0.006 H A -133 0.5 -0.64 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.791 ? 70.90 +P01112 96 Y H ? P01112 96 Y H T C probably damaging alignment ? deleterious 0.999 0.00574 0.136 0.0192 NO NO ? +2.786 -1.636 -4.422 2 238 20 20 6q21 96 D 1.00 171 0.006 H A -40 0.38 -0.64 ? ? ? ? ? ? ? 0 0 0 +5 PF00071.17 1.212 ? 70.90 +P01112 96 Y I ? P01112 96 Y I ? ? benign alignment ? neutral 0.285 0.115 0.907 0.147 NO NO ? +1.064 -1.636 -2.700 2 238 20 20 6q21 96 D 1.00 171 0.006 H A -26 0.27 -0.64 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 13.505 13.505 70.90 +P01112 96 Y K ? P01112 96 Y K ? ? probably damaging alignment ? deleterious 0.999 0.00574 0.136 0.0192 NO NO ? +2.262 -1.636 -3.898 2 238 20 20 6q21 96 D 1.00 171 0.006 H A -25 2.55 -0.64 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.868 ? 70.90 +P01112 96 Y L ? P01112 96 Y L ? ? benign alignment ? neutral 0.017 0.205 0.954 0.225 NO NO ? +0.403 -1.636 -2.039 2 238 20 20 6q21 96 D 1.00 171 0.006 H A -26 0.34 -0.64 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 20.266 20.266 70.90 +P01112 96 Y M ? P01112 96 Y M ? ? probably damaging alignment ? deleterious 0.993 0.0301 0.696 0.0553 NO NO ? +2.685 -1.636 -4.321 2 238 20 20 6q21 96 D 1.00 171 0.006 H A -30 0.34 -0.64 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.690 ? 70.90 +P01112 96 Y N ? P01112 96 Y N T A probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.547 -1.636 -4.183 2 238 20 20 6q21 96 D 1.00 171 0.006 H A -79 0.82 -0.64 ? ? ? ? ? ? ? 1 0 0 +5 PF00071.17 1.159 ? 70.90 +P01112 96 Y P ? P01112 96 Y P ? ? probably damaging alignment ? deleterious 0.999 0.00574 0.136 0.0192 NO NO ? +2.635 -1.636 -4.271 2 238 20 20 6q21 96 D 1.00 171 0.006 H A -81 0.73 -0.64 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.202 ? 70.90 +P01112 96 Y Q ? P01112 96 Y Q ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.616 -1.636 -4.252 2 238 20 20 6q21 96 D 1.00 171 0.006 H A -49 0.85 -0.64 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.125 ? 70.90 +P01112 96 Y R ? P01112 96 Y R ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.543 -1.636 -4.179 2 238 20 20 6q21 96 D 1.00 171 0.006 H A -20 1.41 -0.64 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.526 ? 70.90 +P01112 96 Y S ? P01112 96 Y S A C probably damaging alignment ? deleterious 0.997 0.0167 0.409 0.0357 NO NO ? +2.117 -1.636 -3.753 2 238 20 20 6q21 96 D 1.00 171 0.006 H A -104 0.48 -0.64 ? ? ? ? ? ? ? 1 1 0 +4 PF00071.17 2.276 ? 70.90 +P01112 96 Y T ? P01112 96 Y T ? ? probably damaging alignment ? deleterious 0.995 0.0277 0.681 0.0521 NO NO ? +2.024 -1.636 -3.660 2 238 20 20 6q21 96 D 1.00 171 0.006 H A -77 0.43 -0.64 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 3.513 ? 70.90 +P01112 96 Y V ? P01112 96 Y V ? ? possibly damaging alignment ? deleterious 0.66 0.0865 0.864 0.119 NO NO ? +0.629 -1.636 -2.265 2 238 20 20 6q21 96 D 1.00 171 0.006 H A -53 0.23 -0.64 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 18.946 18.946 70.90 +P01112 96 Y W ? P01112 96 Y W ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.055 -1.636 -4.691 2 238 20 20 6q21 96 D 1.00 171 0.006 H A 34 0.26 -0.64 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.270 ? 70.90 +P01112 97 R A ? P01112 97 R A ? ? probably damaging alignment ? deleterious 0.972 0.0442 0.766 0.0725 NO NO ? +1.667 -1.655 -3.322 2 238 20 20 6q21 97 D 1.00 171 0.085 H A -85 1.2 -0.28 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 4.110 ? 71.43 +P01112 97 R C ? P01112 97 R C ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.451 -1.655 -5.106 2 238 20 20 6q21 97 D 1.00 171 0.085 H A -65 1.66 -0.28 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 0.918 ? 71.43 +P01112 97 R D ? P01112 97 R D ? ? probably damaging alignment ? deleterious 0.992 0.0314 0.704 0.0568 NO NO ? +2.272 -1.655 -3.927 2 238 20 20 6q21 97 D 1.00 171 0.085 H A -62 0.45 -0.28 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 3.385 ? 71.43 +P01112 97 R E ? P01112 97 R E ? ? possibly damaging alignment ? deleterious 0.949 0.0529 0.792 0.0831 NO NO ? +1.890 -1.655 -3.545 2 238 20 20 6q21 97 D 1.00 171 0.085 H A -35 0.16 -0.28 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 7.268 ? 71.43 +P01112 97 R F ? P01112 97 R F ? ? possibly damaging structure 1.1.1 neutral 0.497 0.0968 0.884 0.129 NO NO ? +1.375 -1.655 -3.030 2 238 20 20 6q21 97 D 1.00 171 0.085 H A 17 1.78 -0.28 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 17.131 17.131 71.43 +P01112 97 R G ? P01112 97 R G A G probably damaging alignment ? deleterious 0.989 0.0346 0.723 0.0608 NO NO ? +1.955 -1.655 -3.610 2 238 20 20 6q21 97 D 1.00 171 0.085 H A -113 0.91 -0.28 ? ? ? ? ? ? ? 0 0 2 +2 PF00071.17 3.119 ? 71.43 +P01112 97 R H ? P01112 97 R H ? ? benign alignment ? neutral 0.369 0.108 0.898 0.14 NO NO ? +1.561 -1.655 -3.216 2 238 20 20 6q21 97 D 1.00 171 0.085 H A -20 1.03 -0.28 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 19.107 19.107 71.43 +P01112 97 R I ? P01112 97 R I ? ? probably damaging alignment ? deleterious 0.962 0.0478 0.779 0.0767 NO NO ? +2.103 -1.655 -3.758 2 238 20 20 6q21 97 D 1.00 171 0.085 H A -6 1.68 -0.28 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 8.079 ? 71.43 +P01112 97 R K ? P01112 97 R K G A benign structure 1.1.1 neutral 0.022 0.195 0.951 0.217 NO NO ? +0.889 -1.655 -2.544 2 238 20 20 6q21 97 D 1.00 171 0.085 H A -5 1.14 -0.28 ? ? ? ? ? ? ? 0 1 0 +1 PF00071.17 19.791 19.791 71.43 +P01112 97 R L ? P01112 97 R L ? ? benign structure 1.1.1 neutral 0.311 0.112 0.904 0.144 NO NO ? +0.882 -1.655 -2.537 2 238 20 20 6q21 97 D 1.00 171 0.085 H A -6 1.75 -0.28 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 18.676 18.676 71.43 +P01112 97 R M ? P01112 97 R M G T probably damaging alignment ? deleterious 0.997 0.0167 0.409 0.0357 NO NO ? +2.856 -1.655 -4.511 2 238 20 20 6q21 97 D 1.00 171 0.085 H A -10 1.75 -0.28 ? ? ? ? ? ? ? 1 1 0 +1 PF00071.17 2.479 ? 71.43 +P01112 97 R N ? P01112 97 R N ? ? probably damaging alignment ? deleterious 0.992 0.0314 0.704 0.0568 NO NO ? +2.206 -1.655 -3.861 2 238 20 20 6q21 97 D 1.00 171 0.085 H A -59 0.59 -0.28 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 3.144 ? 71.43 +P01112 97 R P ? P01112 97 R P ? ? probably damaging alignment ? deleterious 0.996 0.0222 0.545 0.0439 NO NO ? +2.470 -1.655 -4.125 2 238 20 20 6q21 97 D 1.00 171 0.085 H A -61 0.68 -0.28 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.937 ? 71.43 +P01112 97 R Q ? P01112 97 R Q ? ? possibly damaging alignment ? deleterious 0.647 0.088 0.866 0.121 NO NO ? +1.365 -1.655 -3.020 2 238 20 20 6q21 97 D 1.00 171 0.085 H A -29 0.56 -0.28 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 15.054 15.054 71.43 +P01112 97 R S ? P01112 97 R S G C probably damaging alignment ? deleterious 0.989 0.0346 0.723 0.0608 NO NO ? +1.985 -1.655 -3.640 2 238 20 20 6q21 97 D 1.00 171 0.085 H A -84 0.93 -0.28 ? ? ? ? ? ? ? 1 2 0 +0 PF00071.17 3.889 ? 71.43 +P01112 97 R T ? P01112 97 R T G C probably damaging alignment ? deleterious 0.989 0.0346 0.723 0.0608 NO NO ? +1.986 -1.655 -3.641 2 238 20 20 6q21 97 D 1.00 171 0.085 H A -57 0.98 -0.28 ? ? ? ? ? ? ? 1 1 2 +1 PF00071.17 2.882 ? 71.43 +P01112 97 R V ? P01112 97 R V ? ? possibly damaging structure 1.1.1 deleterious 0.685 0.0836 0.861 0.116 NO NO ? +1.006 -1.655 -2.661 2 238 20 20 6q21 97 D 1.00 171 0.085 H A -33 1.64 -0.28 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 13.248 13.248 71.43 +P01112 97 R W ? P01112 97 R W A T benign structure 1.1.1 neutral 0.222 0.122 0.914 0.153 NO NO ? +0.827 -1.655 -2.482 2 238 20 20 6q21 97 D 1.00 171 0.085 H A 54 1.67 -0.28 ? ? ? ? ? ? ? 1 0 0 +2 PF00071.17 25.221 25.221 71.43 +P01112 97 R Y ? P01112 97 R Y ? ? possibly damaging structure 1.1.1 neutral 0.497 0.0968 0.884 0.129 NO NO ? +1.331 -1.655 -2.986 2 238 20 20 6q21 97 D 1.00 171 0.085 H A 20 1.41 -0.28 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 17.465 17.465 71.43 +P01112 98 E A ? P01112 98 E A A C benign alignment ? neutral 0.047 0.168 0.942 0.195 NO NO ? +1.208 -1.496 -2.704 2 238 20 20 6q21 98 D 1.00 171 0.406 H A -50 1.04 0.23 ? ? ? ? ? ? ? 1 1 2 -3 PF00071.17 20.843 20.843 78.84 +P01112 98 E C ? P01112 98 E C ? ? probably damaging alignment ? deleterious 0.997 0.0167 0.409 0.0357 NO NO ? +3.764 -1.496 -5.260 2 238 20 20 6q21 98 D 1.00 171 0.406 H A -30 1.5 0.23 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.542 ? 78.84 +P01112 98 E D ? P01112 98 E D G C benign alignment ? neutral 0.001 0.852 0.994 0.514 NO NO ? +0.305 -1.496 -1.801 2 238 20 20 6q21 98 D 1.00 171 0.406 H A -27 0.29 0.23 ? ? ? ? ? ? ? 1 2 0 -4 PF00071.17 31.276 31.276 78.84 +P01112 98 E F ? P01112 98 E F ? ? probably damaging alignment ? deleterious 0.998 0.0112 0.273 0.0274 NO NO ? +2.954 -1.496 -4.450 2 238 20 20 6q21 98 D 1.00 171 0.406 H A 52 1.62 0.23 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.586 ? 78.84 +P01112 98 E G ? P01112 98 E G A G benign alignment ? neutral 0.14 0.136 0.923 0.167 NO NO ? +0.998 -1.496 -2.494 2 238 20 20 6q21 98 D 1.00 171 0.406 H A -78 0.75 0.23 ? ? ? ? ? ? ? 0 1 0 -3 PF00071.17 37.228 37.228 78.84 +P01112 98 E H ? P01112 98 E H ? ? probably damaging alignment ? deleterious 0.993 0.0301 0.696 0.0553 NO NO ? +3.045 -1.496 -4.541 2 238 20 20 6q21 98 D 1.00 171 0.406 H A 15 0.87 0.23 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.187 ? 78.84 +P01112 98 E I ? P01112 98 E I ? ? possibly damaging alignment ? deleterious 0.922 0.0588 0.809 0.0896 NO NO ? +2.654 -1.496 -4.150 2 238 20 20 6q21 98 D 1.00 171 0.406 H A 29 1.52 0.23 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 3.307 ? 78.84 +P01112 98 E K ? P01112 98 E K G A benign alignment ? neutral 0.28 0.116 0.908 0.147 NO NO ? +1.283 -1.496 -2.779 2 238 20 20 6q21 98 D 1.00 171 0.406 H A 30 1.3 0.23 ? ? ? ? ? ? ? 0 0 0 -2 PF00071.17 17.885 17.885 78.84 +P01112 98 E L ? P01112 98 E L ? ? possibly damaging alignment ? deleterious 0.922 0.0588 0.809 0.0896 NO NO ? +2.239 -1.496 -3.735 2 238 20 20 6q21 98 D 1.00 171 0.406 H A 29 1.59 0.23 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 4.284 ? 78.84 +P01112 98 E M ? P01112 98 E M ? ? probably damaging alignment ? deleterious 0.98 0.0405 0.753 0.0679 NO NO ? +3.369 -1.496 -4.865 2 238 20 20 6q21 98 D 1.00 171 0.406 H A 25 1.59 0.23 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.543 ? 78.84 +P01112 98 E N ? P01112 98 E N ? ? benign alignment ? neutral 0.101 0.145 0.929 0.174 NO NO ? +1.371 -1.496 -2.867 2 238 20 20 6q21 98 D 1.00 171 0.406 H A -24 0.43 0.23 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 17.093 17.093 78.84 +P01112 98 E P ? P01112 98 E P ? ? possibly damaging alignment ? deleterious 0.782 0.0746 0.848 0.107 NO NO ? +2.374 -1.496 -3.870 2 238 20 20 6q21 98 D 1.00 171 0.406 H A -26 0.52 0.23 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.091 ? 78.84 +P01112 98 E Q ? P01112 98 E Q G C benign alignment ? neutral 0.217 0.122 0.914 0.153 NO NO ? +1.223 -1.496 -2.719 2 238 20 20 6q21 98 D 1.00 171 0.406 H A 6 0.4 0.23 ? ? ? ? ? ? ? 1 0 0 -2 PF00071.17 15.281 15.281 78.84 +P01112 98 E R ? P01112 98 E R ? ? possibly damaging alignment ? deleterious 0.927 0.0581 0.807 0.0889 NO NO ? +2.264 -1.496 -3.760 2 238 20 20 6q21 98 D 1.00 171 0.406 H A 35 0.16 0.23 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 6.919 ? 78.84 +P01112 98 E S ? P01112 98 E S ? ? possibly damaging alignment ? deleterious 0.662 0.0862 0.864 0.119 NO NO ? +1.809 -1.496 -3.305 2 238 20 20 6q21 98 D 1.00 171 0.406 H A -49 0.77 0.23 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 6.062 ? 78.84 +P01112 98 E T ? P01112 98 E T ? ? benign alignment ? neutral 0.277 0.116 0.908 0.147 NO NO ? +1.370 -1.496 -2.866 2 238 20 20 6q21 98 D 1.00 171 0.406 H A -22 0.82 0.23 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 15.353 15.353 78.84 +P01112 98 E V ? P01112 98 E V A T possibly damaging alignment ? deleterious 0.761 0.0768 0.852 0.109 NO NO ? +2.231 -1.496 -3.727 2 238 20 20 6q21 98 D 1.00 171 0.406 H A 2 1.48 0.23 ? ? ? ? ? ? ? 1 1 0 -3 PF00071.17 4.914 ? 78.84 +P01112 98 E W ? P01112 98 E W ? ? probably damaging alignment ? deleterious 0.999 0.00574 0.136 0.0192 NO NO ? +4.015 -1.496 -5.511 2 238 20 20 6q21 98 D 1.00 171 0.406 H A 89 1.51 0.23 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 0.474 ? 78.84 +P01112 98 E Y ? P01112 98 E Y ? ? probably damaging alignment ? deleterious 0.999 0.00574 0.136 0.0192 NO NO ? +2.897 -1.496 -4.393 2 238 20 20 6q21 98 D 1.00 171 0.406 H A 55 1.25 0.23 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.409 ? 78.84 +P01112 99 Q A ? P01112 99 Q A ? ? probably damaging alignment ? deleterious 0.987 0.036 0.731 0.0626 NO NO ? +1.829 -1.430 -3.259 2 238 20 20 6q21 99 D 1.00 171 0.122 H A -56 0.64 0.26 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 4.337 ? 78.84 +P01112 99 Q C ? P01112 99 Q C ? ? probably damaging alignment ? deleterious 0.999 0.00574 0.136 0.0192 NO NO ? +3.768 -1.430 -5.198 2 238 20 20 6q21 99 D 1.00 171 0.122 H A -36 1.1 0.26 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 0.734 ? 78.84 +P01112 99 Q D ? P01112 99 Q D ? ? probably damaging alignment ? deleterious 0.975 0.0436 0.762 0.072 NO NO ? +2.039 -1.430 -3.469 2 238 20 20 6q21 99 D 1.00 171 0.122 H A -33 0.11 0.26 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 7.135 ? 78.84 +P01112 99 Q E ? P01112 99 Q E C G benign alignment ? neutral 0.143 0.136 0.923 0.166 NO NO ? +0.968 -1.430 -2.398 2 238 20 20 6q21 99 D 1.00 171 0.122 H A -6 0.4 0.26 ? ? ? ? ? ? ? 1 0 0 -5 PF00071.17 23.419 23.419 78.84 +P01112 99 Q F ? P01112 99 Q F ? ? probably damaging alignment ? deleterious 0.999 0.00574 0.136 0.0192 NO NO ? +2.846 -1.430 -4.276 2 238 20 20 6q21 99 D 1.00 171 0.122 H A 46 1.22 0.26 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.041 ? 78.84 +P01112 99 Q G ? P01112 99 Q G ? ? probably damaging alignment ? deleterious 0.996 0.0222 0.545 0.0439 NO NO ? +2.112 -1.430 -3.542 2 238 20 20 6q21 99 D 1.00 171 0.122 H A -84 0.35 0.26 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.813 ? 78.84 +P01112 99 Q H ? P01112 99 Q H G C benign alignment ? neutral 0.138 0.137 0.923 0.167 NO NO ? +0.954 -1.430 -2.384 2 238 20 20 6q21 99 D 1.00 171 0.122 H A 9 0.47 0.26 ? ? ? ? ? ? ? 1 2 0 -7 PF00071.17 19.107 19.107 78.84 +P01112 99 Q I ? P01112 99 Q I ? ? possibly damaging structure 1.1.1 deleterious 0.858 0.0668 0.831 0.0982 NO NO ? +1.325 -1.430 -2.755 2 238 20 20 6q21 99 D 1.00 171 0.122 H A 23 1.12 0.26 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 12.355 12.355 78.84 +P01112 99 Q K ? P01112 99 Q K C A probably damaging alignment ? deleterious 0.975 0.0436 0.762 0.072 NO NO ? +1.850 -1.430 -3.280 2 238 20 20 6q21 99 D 1.00 171 0.122 H A 24 1.7 0.26 ? ? ? ? ? ? ? 1 0 0 -5 PF00071.17 5.998 ? 78.84 +P01112 99 Q L ? P01112 99 Q L A T probably damaging alignment ? deleterious 0.975 0.0436 0.762 0.072 NO NO ? +2.000 -1.430 -3.430 2 238 20 20 6q21 99 D 1.00 171 0.122 H A 23 1.19 0.26 ? ? ? ? ? ? ? 1 1 0 -6 PF00071.17 7.626 ? 78.84 +P01112 99 Q M ? P01112 99 Q M ? ? probably damaging alignment ? deleterious 0.999 0.00574 0.136 0.0192 NO NO ? +3.095 -1.430 -4.525 2 238 20 20 6q21 99 D 1.00 171 0.122 H A 19 1.19 0.26 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.680 ? 78.84 +P01112 99 Q N ? P01112 99 Q N ? ? probably damaging alignment ? deleterious 0.987 0.036 0.731 0.0626 NO NO ? +2.197 -1.430 -3.627 2 238 20 20 6q21 99 D 1.00 171 0.122 H A -30 0.0299999999999999 0.26 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 3.207 ? 78.84 +P01112 99 Q P ? P01112 99 Q P A C benign alignment ? neutral 0.401 0.105 0.895 0.137 NO NO ? +1.456 -1.430 -2.886 2 238 20 20 6q21 99 D 1.00 171 0.122 H A -32 0.12 0.26 ? ? ? ? ? ? ? 1 1 2 -6 PF00071.17 35.338 35.338 78.84 +P01112 99 Q R ? P01112 99 Q R A G possibly damaging alignment ? deleterious 0.507 0.0964 0.883 0.129 NO NO ? +1.158 -1.430 -2.588 2 238 20 20 6q21 99 D 1.00 171 0.122 H A 29 0.56 0.26 ? ? ? ? ? ? ? 0 1 2 -6 PF00071.17 15.837 15.837 78.84 +P01112 99 Q S ? P01112 99 Q S ? ? probably damaging alignment ? deleterious 0.996 0.0222 0.545 0.0439 NO NO ? +1.987 -1.430 -3.417 2 238 20 20 6q21 99 D 1.00 171 0.122 H A -55 0.37 0.26 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 4.288 ? 78.84 +P01112 99 Q T ? P01112 99 Q T ? ? possibly damaging alignment ? deleterious 0.909 0.0611 0.815 0.0922 NO NO ? +2.173 -1.430 -3.603 2 238 20 20 6q21 99 D 1.00 171 0.122 H A -28 0.42 0.26 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.975 ? 78.84 +P01112 99 Q V ? P01112 99 Q V ? ? possibly damaging alignment ? deleterious 0.939 0.0562 0.8 0.0869 NO NO ? +2.102 -1.430 -3.532 2 238 20 20 6q21 99 D 1.00 171 0.122 H A -4 1.08 0.26 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 8.021 ? 78.84 +P01112 99 Q W ? P01112 99 Q W ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.903 -1.430 -5.333 2 238 20 20 6q21 99 D 1.00 171 0.122 H A 83 1.11 0.26 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 0.384 ? 78.84 +P01112 99 Q Y ? P01112 99 Q Y ? ? probably damaging alignment ? deleterious 0.993 0.0301 0.696 0.0553 NO NO ? +2.563 -1.430 -3.993 2 238 20 20 6q21 99 D 1.00 171 0.122 H A 49 0.85 0.26 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 3.132 ? 78.84 +P01112 100 I A ? P01112 100 I A ? ? possibly damaging alignment ? neutral 0.455 0.0995 0.889 0.132 NO NO ? +0.973 -1.338 -2.311 2 238 20 20 6q21 100 D 1.00 171 0.000 H A -79 0.48 -0.67 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 21.916 21.916 82.54 +P01112 100 I C ? P01112 100 I C ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.378 -1.338 -4.716 2 238 20 20 6q21 100 D 1.00 171 0.000 H A -59 0.02 -0.67 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.621 ? 82.54 +P01112 100 I D ? P01112 100 I D ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.720 -1.338 -4.058 2 238 20 20 6q21 100 D 1.00 171 0.000 H A -56 1.23 -0.67 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.210 ? 82.54 +P01112 100 I E ? P01112 100 I E ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.576 -1.338 -3.914 2 238 20 20 6q21 100 D 1.00 171 0.000 H A -29 1.52 -0.67 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 3.046 ? 82.54 +P01112 100 I F ? P01112 100 I F A T probably damaging alignment ? deleterious 0.984 0.0381 0.743 0.065 NO NO ? +2.447 -1.338 -3.785 2 238 20 20 6q21 100 D 1.00 171 0.000 H A 23 0.1 -0.67 ? ? ? ? ? ? ? 1 0 0 -8 PF00071.17 4.519 ? 82.54 +P01112 100 I G ? P01112 100 I G ? ? probably damaging alignment ? deleterious 0.995 0.0277 0.681 0.0521 NO NO ? +2.402 -1.338 -3.740 2 238 20 20 6q21 100 D 1.00 171 0.000 H A -107 0.77 -0.67 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 5.929 ? 82.54 +P01112 100 I H ? P01112 100 I H ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.646 -1.338 -4.984 2 238 20 20 6q21 100 D 1.00 171 0.000 H A -14 0.65 -0.67 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.129 ? 82.54 +P01112 100 I K ? P01112 100 I K ? ? probably damaging alignment ? deleterious 0.997 0.0167 0.409 0.0357 NO NO ? +2.526 -1.338 -3.864 2 238 20 20 6q21 100 D 1.00 171 0.000 H A 1 2.82 -0.67 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 3.412 ? 82.54 +P01112 100 I L ? P01112 100 I L A C benign alignment ? neutral 0.003 0.556 0.981 0.39 NO NO ? +0.257 -1.338 -1.595 2 238 20 20 6q21 100 D 1.00 171 0.000 H A 0 0.07 -0.67 ? ? ? ? ? ? ? 1 0 0 -8 PF00071.17 30.995 30.995 82.54 +P01112 100 I M ? P01112 100 I M C G probably damaging alignment ? deleterious 0.993 0.0301 0.696 0.0553 NO NO ? +2.768 -1.338 -4.106 2 238 20 20 6q21 100 D 1.00 171 0.000 H A -4 0.07 -0.67 ? ? ? ? ? ? ? 1 2 0 -10 PF00071.17 4.114 ? 82.54 +P01112 100 I N ? P01112 100 I N T A probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.864 -1.338 -4.202 2 238 20 20 6q21 100 D 1.00 171 0.000 H A -53 1.09 -0.67 ? ? ? ? ? ? ? 1 1 0 -9 PF00071.17 1.987 ? 82.54 +P01112 100 I P ? P01112 100 I P ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.791 -1.338 -4.129 2 238 20 20 6q21 100 D 1.00 171 0.000 H A -55 1 -0.67 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.199 ? 82.54 +P01112 100 I Q ? P01112 100 I Q ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.969 -1.338 -4.307 2 238 20 20 6q21 100 D 1.00 171 0.000 H A -23 1.12 -0.67 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.962 ? 82.54 +P01112 100 I R ? P01112 100 I R ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.795 -1.338 -4.133 2 238 20 20 6q21 100 D 1.00 171 0.000 H A 6 1.68 -0.67 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.393 ? 82.54 +P01112 100 I S ? P01112 100 I S T G probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.273 -1.338 -3.611 2 238 20 20 6q21 100 D 1.00 171 0.000 H A -78 0.75 -0.67 ? ? ? ? ? ? ? 1 1 0 -9 PF00071.17 6.374 ? 82.54 +P01112 100 I T ? P01112 100 I T T C probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.143 -1.338 -3.481 2 238 20 20 6q21 100 D 1.00 171 0.000 H A -51 0.7 -0.67 ? ? ? ? ? ? ? 0 1 0 -9 PF00071.17 3.790 ? 82.54 +P01112 100 I V ? P01112 100 I V A G benign alignment ? neutral 0.233 0.121 0.912 0.152 NO NO ? +0.960 -1.338 -2.298 2 238 20 20 6q21 100 D 1.00 171 0.000 H A -27 0.04 -0.67 ? ? ? ? ? ? ? 0 0 0 -8 PF00071.17 11.823 11.823 82.54 +P01112 100 I W ? P01112 100 I W ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +4.020 -1.338 -5.358 2 238 20 20 6q21 100 D 1.00 171 0.000 H A 60 0.01 -0.67 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 0.611 ? 82.54 +P01112 100 I Y ? P01112 100 I Y ? ? probably damaging alignment ? deleterious 0.999 0.00574 0.136 0.0192 NO NO ? +2.732 -1.338 -4.070 2 238 20 20 6q21 100 D 1.00 171 0.000 H A 26 0.27 -0.67 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.844 ? 82.54 +P01112 101 K A ? P01112 101 K A ? ? possibly damaging alignment ? deleterious 0.904 0.0621 0.816 0.0934 NO NO ? +1.552 -1.748 -3.300 2 238 20 20 6q21 101 D 1.00 171 0.198 H A -80 2.34 -0.36 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 4.636 ? 82.54 +P01112 101 K C ? P01112 101 K C ? ? probably damaging alignment ? deleterious 0.999 0.00574 0.136 0.0192 NO NO ? +3.386 -1.748 -5.134 2 238 20 20 6q21 101 D 1.00 171 0.198 H A -60 2.8 -0.36 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.124 ? 82.54 +P01112 101 K D ? P01112 101 K D ? ? probably damaging alignment ? deleterious 0.971 0.0444 0.768 0.0727 NO NO ? +1.978 -1.748 -3.726 2 238 20 20 6q21 101 D 1.00 171 0.198 H A -57 1.59 -0.36 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 6.834 ? 82.54 +P01112 101 K E ? P01112 101 K E A G possibly damaging alignment ? deleterious 0.681 0.0843 0.862 0.117 NO NO ? +1.626 -1.748 -3.374 2 238 20 20 6q21 101 D 1.00 171 0.198 H A -30 1.3 -0.36 ? ? ? ? ? ? ? 0 0 2 -11 PF00071.17 8.525 ? 82.54 +P01112 101 K F ? P01112 101 K F ? ? probably damaging alignment ? deleterious 0.963 0.0475 0.778 0.0764 NO NO ? +2.475 -1.748 -4.223 2 238 20 20 6q21 101 D 1.00 171 0.198 H A 22 2.92 -0.36 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 3.882 ? 82.54 +P01112 101 K G ? P01112 101 K G ? ? probably damaging alignment ? deleterious 0.971 0.0444 0.768 0.0727 NO NO ? +1.852 -1.748 -3.600 2 238 20 20 6q21 101 D 1.00 171 0.198 H A -108 2.05 -0.36 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 5.252 ? 82.54 +P01112 101 K H ? P01112 101 K H ? ? possibly damaging alignment ? deleterious 0.574 0.0937 0.876 0.127 NO NO ? +1.526 -1.748 -3.274 2 238 20 20 6q21 101 D 1.00 171 0.198 H A -15 2.17 -0.36 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 15.922 15.922 82.54 +P01112 101 K I ? P01112 101 K I A T benign alignment ? neutral 0.029 0.183 0.948 0.207 NO NO ? +1.266 -1.748 -3.014 2 238 20 20 6q21 101 D 1.00 171 0.198 H A -1 2.82 -0.36 ? ? ? ? ? ? ? 1 1 0 -12 PF00071.17 15.516 15.516 82.54 +P01112 101 K L ? P01112 101 K L ? ? benign alignment ? neutral 0.001 0.852 0.994 0.514 NO NO ? +0.352 -1.748 -2.100 2 238 20 20 6q21 101 D 1.00 171 0.198 H A -1 2.89 -0.36 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 26.624 26.624 82.54 +P01112 101 K M ? P01112 101 K M ? ? possibly damaging alignment ? deleterious 0.53 0.0954 0.881 0.128 NO NO ? +1.541 -1.748 -3.289 2 238 20 20 6q21 101 D 1.00 171 0.198 H A -5 2.89 -0.36 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 9.170 9.170 82.54 +P01112 101 K N ? P01112 101 K N A C benign alignment ? neutral 0.093 0.148 0.931 0.177 NO NO ? +0.969 -1.748 -2.717 2 238 20 20 6q21 101 D 1.00 171 0.198 H A -54 1.73 -0.36 ? ? ? ? ? ? ? 1 2 0 -13 PF00071.17 25.975 25.975 82.54 +P01112 101 K P ? P01112 101 K P ? ? probably damaging alignment ? deleterious 0.993 0.0301 0.696 0.0553 NO NO ? +2.261 -1.748 -4.009 2 238 20 20 6q21 101 D 1.00 171 0.198 H A -56 1.82 -0.36 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.040 ? 82.54 +P01112 101 K Q ? P01112 101 K Q A C benign alignment ? neutral 0.023 0.193 0.95 0.216 NO NO ? +0.509 -1.748 -2.257 2 238 20 20 6q21 101 D 1.00 171 0.198 H A -24 1.7 -0.36 ? ? ? ? ? ? ? 1 0 0 -11 PF00071.17 17.658 17.658 82.54 +P01112 101 K R ? P01112 101 K R A G benign alignment ? neutral 0.008 0.239 0.963 0.252 NO NO ? +0.592 -1.748 -2.340 2 238 20 20 6q21 101 D 1.00 171 0.198 H A 5 1.14 -0.36 ? ? ? ? ? ? ? 0 1 0 -12 PF00071.17 26.395 26.395 82.54 +P01112 101 K S ? P01112 101 K S ? ? possibly damaging alignment ? deleterious 0.904 0.0621 0.816 0.0934 NO NO ? +1.724 -1.748 -3.472 2 238 20 20 6q21 101 D 1.00 171 0.198 H A -79 2.07 -0.36 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 5.780 ? 82.54 +P01112 101 K T ? P01112 101 K T A C possibly damaging alignment ? deleterious 0.937 0.0566 0.801 0.0874 NO NO ? +1.858 -1.748 -3.606 2 238 20 20 6q21 101 D 1.00 171 0.198 H A -52 2.12 -0.36 ? ? ? ? ? ? ? 1 1 0 -12 PF00071.17 4.107 ? 82.54 +P01112 101 K V ? P01112 101 K V ? ? benign alignment ? neutral 0.268 0.117 0.909 0.148 NO NO ? +1.731 -1.748 -3.479 2 238 20 20 6q21 101 D 1.00 171 0.198 H A -28 2.78 -0.36 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 10.073 ? 82.54 +P01112 101 K W ? P01112 101 K W ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.661 -1.748 -5.409 2 238 20 20 6q21 101 D 1.00 171 0.198 H A 59 2.81 -0.36 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 0.548 ? 82.54 +P01112 101 K Y ? P01112 101 K Y ? ? possibly damaging alignment ? deleterious 0.862 0.0664 0.83 0.0979 NO NO ? +2.432 -1.748 -4.180 2 238 20 20 6q21 101 D 1.00 171 0.198 H A 25 2.55 -0.36 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.610 ? 82.54 +P01112 102 R A ? P01112 102 R A ? ? possibly damaging alignment ? deleterious 0.666 0.0857 0.864 0.119 NO NO ? +1.691 -1.525 -3.216 2 238 20 20 6q21 102 D 1.00 171 0.590 H A -85 1.2 0.07 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 8.960 ? 82.01 +P01112 102 R C ? P01112 102 R C ? ? probably damaging alignment ? deleterious 0.997 0.0167 0.409 0.0357 NO NO ? +3.647 -1.525 -5.172 2 238 20 20 6q21 102 D 1.00 171 0.590 H A -65 1.66 0.07 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.495 ? 82.01 +P01112 102 R D ? P01112 102 R D ? ? possibly damaging alignment ? deleterious 0.875 0.0653 0.826 0.0967 NO NO ? +2.180 -1.525 -3.705 2 238 20 20 6q21 102 D 1.00 171 0.590 H A -62 0.45 0.07 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 6.465 ? 82.01 +P01112 102 R E ? P01112 102 R E ? ? benign alignment ? neutral 0.02 0.198 0.952 0.22 NO NO ? +1.277 -1.525 -2.802 2 238 20 20 6q21 102 D 1.00 171 0.590 H A -35 0.16 0.07 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 21.219 21.219 82.01 +P01112 102 R F ? P01112 102 R F ? ? possibly damaging alignment ? deleterious 0.955 0.0505 0.786 0.0801 NO NO ? +2.769 -1.525 -4.294 2 238 20 20 6q21 102 D 1.00 171 0.590 H A 17 1.78 0.07 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.931 ? 82.01 +P01112 102 R G ? P01112 102 R G C G benign alignment ? neutral 0.053 0.164 0.94 0.191 NO NO ? +0.832 -1.525 -2.357 2 238 20 20 6q21 102 D 1.00 171 0.590 H A -113 0.91 0.07 ? ? ? ? ? ? ? 1 0 1 -14 PF00071.17 40.195 40.195 82.01 +P01112 102 R H ? P01112 102 R H ? ? probably damaging alignment ? deleterious 0.978 0.0417 0.756 0.0695 NO NO ? +3.049 -1.525 -4.574 2 238 20 20 6q21 102 D 1.00 171 0.590 H A -20 1.03 0.07 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.381 ? 82.01 +P01112 102 R I ? P01112 102 R I ? ? possibly damaging alignment ? neutral 0.453 0.0997 0.889 0.132 NO NO ? +1.597 -1.525 -3.122 2 238 20 20 6q21 102 D 1.00 171 0.590 H A -6 1.68 0.07 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 12.499 12.499 82.01 +P01112 102 R K ? P01112 102 R K ? ? benign alignment ? neutral 0.033 0.179 0.946 0.204 NO NO ? +0.995 -1.525 -2.520 2 238 20 20 6q21 102 D 1.00 171 0.590 H A -5 1.14 0.07 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 14.953 14.953 82.01 +P01112 102 R L ? P01112 102 R L G T possibly damaging alignment ? deleterious 0.848 0.0674 0.834 0.0988 NO NO ? +1.920 -1.525 -3.445 2 238 20 20 6q21 102 D 1.00 171 0.590 H A -6 1.75 0.07 ? ? ? ? ? ? ? 1 1 1 -15 PF00071.17 8.141 ? 82.01 +P01112 102 R M ? P01112 102 R M ? ? possibly damaging alignment ? neutral 0.453 0.0997 0.889 0.132 NO NO ? +1.809 -1.525 -3.334 2 238 20 20 6q21 102 D 1.00 171 0.590 H A -10 1.75 0.07 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 6.685 6.685 82.01 +P01112 102 R N ? P01112 102 R N ? ? possibly damaging alignment ? deleterious 0.933 0.0573 0.804 0.0882 NO NO ? +2.176 -1.525 -3.701 2 238 20 20 6q21 102 D 1.00 171 0.590 H A -59 0.59 0.07 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 4.509 ? 82.01 +P01112 102 R P ? P01112 102 R P G C probably damaging alignment ? deleterious 0.982 0.0393 0.748 0.0664 NO NO ? +2.495 -1.525 -4.020 2 238 20 20 6q21 102 D 1.00 171 0.590 H A -61 0.68 0.07 ? ? ? ? ? ? ? 1 1 3 -15 PF00071.17 2.388 ? 82.01 +P01112 102 R Q ? P01112 102 R Q G A possibly damaging alignment ? neutral 0.471 0.0989 0.887 0.131 NO NO ? +1.045 -1.525 -2.570 2 238 20 20 6q21 102 D 1.00 171 0.590 H A -29 0.56 0.07 ? ? ? ? ? ? ? 0 1 1 -15 PF00071.17 16.639 16.639 82.01 +P01112 102 R S ? P01112 102 R S ? ? benign alignment ? neutral 0.221 0.122 0.914 0.153 NO NO ? +1.113 -1.525 -2.638 2 238 20 20 6q21 102 D 1.00 171 0.590 H A -84 0.93 0.07 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 18.036 18.036 82.01 +P01112 102 R T ? P01112 102 R T ? ? possibly damaging alignment ? deleterious 0.875 0.0653 0.826 0.0967 NO NO ? +2.074 -1.525 -3.599 2 238 20 20 6q21 102 D 1.00 171 0.590 H A -57 0.98 0.07 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 6.736 ? 82.01 +P01112 102 R V ? P01112 102 R V ? ? possibly damaging alignment ? deleterious 0.678 0.0847 0.862 0.117 NO NO ? +2.140 -1.525 -3.665 2 238 20 20 6q21 102 D 1.00 171 0.590 H A -33 1.64 0.07 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 8.115 ? 82.01 +P01112 102 R W ? P01112 102 R W C T possibly damaging alignment ? deleterious 0.781 0.0747 0.848 0.107 NO NO ? +1.854 -1.525 -3.379 2 238 20 20 6q21 102 D 1.00 171 0.590 H A 54 1.67 0.07 ? ? ? ? ? ? ? 0 0 1 -14 PF00071.17 22.331 22.331 82.01 +P01112 102 R Y ? P01112 102 R Y ? ? possibly damaging alignment ? deleterious 0.848 0.0674 0.834 0.0988 NO NO ? +2.721 -1.525 -4.246 2 238 20 20 6q21 102 D 1.00 171 0.590 H A 20 1.41 0.07 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 3.063 ? 82.01 +P01112 103 V A ? P01112 103 V A T C possibly damaging alignment ? deleterious 0.657 0.0868 0.865 0.12 NO NO ? +1.031 -1.325 -2.356 2 238 20 20 6q21 103 D 1.00 171 0.217 H A -52 0.44 0.45 ? ? ? ? ? ? ? 0 1 2 -18 PF00071.17 16.399 16.399 75.66 +P01112 103 V C ? P01112 103 V C ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.472 -1.325 -4.797 2 238 20 20 6q21 103 D 1.00 171 0.217 H A -32 0.02 0.45 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.383 ? 75.66 +P01112 103 V D ? P01112 103 V D ? ? probably damaging alignment ? deleterious 0.997 0.0167 0.409 0.0357 NO NO ? +2.689 -1.325 -4.014 2 238 20 20 6q21 103 D 1.00 171 0.217 H A -29 1.19 0.45 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.819 ? 75.66 +P01112 103 V E ? P01112 103 V E T A probably damaging alignment ? deleterious 0.974 0.0438 0.763 0.0722 NO NO ? +2.468 -1.325 -3.793 2 238 20 20 6q21 103 D 1.00 171 0.217 H A -2 1.48 0.45 ? ? ? ? ? ? ? 1 1 0 -18 PF00071.17 3.727 ? 75.66 +P01112 103 V F ? P01112 103 V F ? ? possibly damaging alignment ? deleterious 0.919 0.0594 0.811 0.0903 NO NO ? +1.646 -1.325 -2.971 2 238 20 20 6q21 103 D 1.00 171 0.217 H A 50 0.14 0.45 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 17.335 17.335 75.66 +P01112 103 V G ? P01112 103 V G T G probably damaging alignment ? deleterious 0.997 0.0167 0.409 0.0357 NO NO ? +2.326 -1.325 -3.651 2 238 20 20 6q21 103 D 1.00 171 0.217 H A -80 0.73 0.45 ? ? ? ? ? ? ? 1 1 0 -18 PF00071.17 4.436 ? 75.66 +P01112 103 V H ? P01112 103 V H ? ? probably damaging alignment ? deleterious 0.999 0.00574 0.136 0.0192 NO NO ? +3.593 -1.325 -4.918 2 238 20 20 6q21 103 D 1.00 171 0.217 H A 13 0.61 0.45 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.717 ? 75.66 +P01112 103 V I ? P01112 103 V I ? ? benign alignment ? neutral 0.282 0.116 0.907 0.147 NO NO ? +1.069 -1.325 -2.394 2 238 20 20 6q21 103 D 1.00 171 0.217 H A 27 0.04 0.45 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 13.505 13.505 75.66 +P01112 103 V K ? P01112 103 V K ? ? probably damaging alignment ? deleterious 0.982 0.0393 0.748 0.0664 NO NO ? +2.404 -1.325 -3.729 2 238 20 20 6q21 103 D 1.00 171 0.217 H A 28 2.78 0.45 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 8.627 ? 75.66 +P01112 103 V L ? P01112 103 V L G C benign alignment ? neutral 0.029 0.183 0.948 0.207 NO NO ? +0.814 -1.325 -2.139 2 238 20 20 6q21 103 D 1.00 171 0.217 H A 27 0.11 0.45 ? ? ? ? ? ? ? 1 0 0 -17 PF00071.17 19.074 19.074 75.66 +P01112 103 V M ? P01112 103 V M G A probably damaging alignment ? deleterious 0.999 0.00574 0.136 0.0192 NO NO ? +2.919 -1.325 -4.244 2 238 20 20 6q21 103 D 1.00 171 0.217 H A 23 0.11 0.45 ? ? ? ? ? ? ? 0 0 0 -17 PF00071.17 2.531 ? 75.66 +P01112 103 V N ? P01112 103 V N ? ? probably damaging alignment ? deleterious 0.984 0.0381 0.743 0.065 NO NO ? +2.802 -1.325 -4.127 2 238 20 20 6q21 103 D 1.00 171 0.217 H A -26 1.05 0.45 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 3.324 ? 75.66 +P01112 103 V P ? P01112 103 V P ? ? probably damaging alignment ? deleterious 0.97 0.0446 0.769 0.0728 NO NO ? +2.731 -1.325 -4.056 2 238 20 20 6q21 103 D 1.00 171 0.217 H A -28 0.96 0.45 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.009 ? 75.66 +P01112 103 V Q ? P01112 103 V Q ? ? probably damaging alignment ? deleterious 0.997 0.0167 0.409 0.0357 NO NO ? +2.876 -1.325 -4.201 2 238 20 20 6q21 103 D 1.00 171 0.217 H A 4 1.08 0.45 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 3.440 ? 75.66 +P01112 103 V R ? P01112 103 V R ? ? possibly damaging alignment ? deleterious 0.727 0.0796 0.856 0.112 NO NO ? +1.717 -1.325 -3.042 2 238 20 20 6q21 103 D 1.00 171 0.217 H A 33 1.64 0.45 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 24.574 24.574 75.66 +P01112 103 V S ? P01112 103 V S ? ? probably damaging alignment ? deleterious 0.984 0.0381 0.743 0.065 NO NO ? +2.270 -1.325 -3.595 2 238 20 20 6q21 103 D 1.00 171 0.217 H A -51 0.71 0.45 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 6.988 ? 75.66 +P01112 103 V T ? P01112 103 V T ? ? possibly damaging alignment ? deleterious 0.712 0.0813 0.858 0.114 NO NO ? +1.405 -1.325 -2.730 2 238 20 20 6q21 103 D 1.00 171 0.217 H A -24 0.66 0.45 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 18.606 18.606 75.66 +P01112 103 V W ? P01112 103 V W ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +4.007 -1.325 -5.332 2 238 20 20 6q21 103 D 1.00 171 0.217 H A 87 0.03 0.45 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 0.805 ? 75.66 +P01112 103 V Y ? P01112 103 V Y ? ? probably damaging alignment ? deleterious 0.996 0.0222 0.545 0.0439 NO NO ? +2.711 -1.325 -4.036 2 238 20 20 6q21 103 D 1.00 171 0.217 H A 53 0.23 0.45 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 4.021 ? 75.66 +P01112 104 K A ? P01112 104 K A ? ? probably damaging alignment ? deleterious 0.998 0.0112 0.273 0.0274 NO NO ? +2.228 -0.900 -3.128 2 238 20 20 6q21 104 D 1.00 171 0.305 T A -80 2.34 0.75 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 5.528 ? 75.66 +P01112 104 K C ? P01112 104 K C ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +4.209 -0.900 -5.109 2 238 20 20 6q21 104 D 1.00 171 0.305 T A -60 2.8 0.75 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.383 ? 75.66 +P01112 104 K D ? P01112 104 K D ? ? probably damaging alignment ? deleterious 0.999 0.00574 0.136 0.0192 NO NO ? +2.660 -0.900 -3.560 2 238 20 20 6q21 104 D 1.00 171 0.305 T A -57 1.59 0.75 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.819 ? 75.66 +P01112 104 K E ? P01112 104 K E A G probably damaging alignment ? deleterious 0.996 0.0222 0.545 0.0439 NO NO ? +2.216 -0.900 -3.116 2 238 20 20 6q21 104 D 1.00 171 0.305 T A -30 1.3 0.75 ? ? ? ? ? ? ? 0 0 0 -20 PF00071.17 3.047 ? 75.66 +P01112 104 K F ? P01112 104 K F ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.442 -0.900 -4.342 2 238 20 20 6q21 104 D 1.00 171 0.305 T A 22 2.92 0.75 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.728 ? 75.66 +P01112 104 K G ? P01112 104 K G ? ? probably damaging alignment ? deleterious 0.999 0.00574 0.136 0.0192 NO NO ? +2.531 -0.900 -3.431 2 238 20 20 6q21 104 D 1.00 171 0.305 T A -108 2.05 0.75 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 3.250 ? 75.66 +P01112 104 K H ? P01112 104 K H ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.623 -0.900 -4.523 2 238 20 20 6q21 104 D 1.00 171 0.305 T A -15 2.17 0.75 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.196 ? 75.66 +P01112 104 K I ? P01112 104 K I ? ? probably damaging alignment ? deleterious 0.993 0.0301 0.696 0.0553 NO NO ? +3.133 -0.900 -4.033 2 238 20 20 6q21 104 D 1.00 171 0.305 T A -1 2.82 0.75 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 4.007 ? 75.66 +P01112 104 K L ? P01112 104 K L ? ? possibly damaging alignment ? deleterious 0.948 0.0532 0.793 0.0833 NO NO ? +2.508 -0.900 -3.408 2 238 20 20 6q21 104 D 1.00 171 0.305 T A -1 2.89 0.75 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 4.942 ? 75.66 +P01112 104 K M ? P01112 104 K M A T probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.653 -0.900 -4.553 2 238 20 20 6q21 104 D 1.00 171 0.305 T A -5 2.89 0.75 ? ? ? ? ? ? ? 1 1 0 -21 PF00071.17 1.501 ? 75.66 +P01112 104 K N ? P01112 104 K N G C probably damaging alignment ? deleterious 0.999 0.00574 0.136 0.0192 NO NO ? +2.621 -0.900 -3.521 2 238 20 20 6q21 104 D 1.00 171 0.305 T A -54 1.73 0.75 ? ? ? ? ? ? ? 1 2 2 -22 PF00071.17 3.324 ? 75.66 +P01112 104 K P ? P01112 104 K P ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.846 -0.900 -3.746 2 238 20 20 6q21 104 D 1.00 171 0.305 T A -56 1.82 0.75 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.009 ? 75.66 +P01112 104 K Q ? P01112 104 K Q A C probably damaging alignment ? deleterious 0.996 0.0222 0.545 0.0439 NO NO ? +2.656 -0.900 -3.556 2 238 20 20 6q21 104 D 1.00 171 0.305 T A -24 1.7 0.75 ? ? ? ? ? ? ? 1 0 0 -20 PF00071.17 2.395 ? 75.66 +P01112 104 K R ? P01112 104 K R A G possibly damaging alignment ? deleterious 0.894 0.0633 0.82 0.0946 NO NO ? +1.612 -0.900 -2.512 2 238 20 20 6q21 104 D 1.00 171 0.305 T A 5 1.14 0.75 ? ? ? ? ? ? ? 0 1 0 -21 PF00071.17 17.111 17.111 75.66 +P01112 104 K S ? P01112 104 K S ? ? probably damaging alignment ? deleterious 0.998 0.0112 0.273 0.0274 NO NO ? +2.329 -0.900 -3.229 2 238 20 20 6q21 104 D 1.00 171 0.305 T A -79 2.07 0.75 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 6.988 ? 75.66 +P01112 104 K T ? P01112 104 K T A C possibly damaging alignment ? deleterious 0.932 0.0575 0.804 0.0883 NO NO ? +1.721 -0.900 -2.621 2 238 20 20 6q21 104 D 1.00 171 0.305 T A -52 2.12 0.75 ? ? ? ? ? ? ? 1 1 2 -21 PF00071.17 18.606 18.606 75.66 +P01112 104 K V ? P01112 104 K V ? ? probably damaging alignment ? deleterious 0.96 0.0483 0.781 0.0774 NO NO ? +2.669 -0.900 -3.569 2 238 20 20 6q21 104 D 1.00 171 0.305 T A -28 2.78 0.75 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 5.412 ? 75.66 +P01112 104 K W ? P01112 104 K W ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +4.473 -0.900 -5.373 2 238 20 20 6q21 104 D 1.00 171 0.305 T A 59 2.81 0.75 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 0.425 ? 75.66 +P01112 104 K Y ? P01112 104 K Y ? ? probably damaging alignment ? deleterious 0.999 0.00574 0.136 0.0192 NO NO ? +3.335 -0.900 -4.235 2 238 20 20 6q21 104 D 1.00 171 0.305 T A 25 2.55 0.75 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.400 ? 75.66 +P01112 105 D A ? P01112 105 D A A C probably damaging alignment ? deleterious 0.96 0.0483 0.781 0.0774 NO NO ? +2.167 -1.117 -3.284 2 237 20 20 6q21 105 D 1.00 171 0.841 T L -23 0.75 0.86 ? ? ? ? ? ? ? 1 1 0 -24 PF00071.17 3.984 ? 77.78 +P01112 105 D C ? P01112 105 D C ? ? probably damaging alignment ? deleterious 0.995 0.0277 0.681 0.0521 NO NO ? +4.062 -1.117 -5.179 2 237 20 20 6q21 105 D 1.00 171 0.841 T L -3 1.21 0.86 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 0.849 ? 77.78 +P01112 105 D E ? P01112 105 D E C G benign alignment ? neutral 0.278 0.116 0.908 0.147 NO NO ? +1.402 -1.117 -2.519 2 237 20 20 6q21 105 D 1.00 171 0.841 T L 27 0.29 0.86 ? ? ? ? ? ? ? 1 2 0 -25 PF00071.17 13.203 13.203 77.78 +P01112 105 D F ? P01112 105 D F ? ? probably damaging alignment ? deleterious 0.999 0.00574 0.136 0.0192 NO NO ? +3.192 -1.117 -4.309 2 237 20 20 6q21 105 D 1.00 171 0.841 T L 79 1.33 0.86 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.405 ? 77.78 +P01112 105 D G ? P01112 105 D G A G benign alignment ? neutral 0.076 0.155 0.934 0.183 NO NO ? +1.011 -1.117 -2.128 2 237 20 20 6q21 105 D 1.00 171 0.841 T L -51 0.46 0.86 ? ? ? ? ? ? ? 0 1 0 -24 PF00071.17 25.898 25.898 77.78 +P01112 105 D H ? P01112 105 D H G C benign alignment ? neutral 0.269 0.116 0.909 0.148 NO NO ? +1.648 -1.117 -2.765 2 237 20 20 6q21 105 D 1.00 171 0.841 T L 42 0.58 0.86 ? ? ? ? ? ? ? 1 0 0 -23 PF00071.17 27.536 27.536 77.78 +P01112 105 D I ? P01112 105 D I ? ? probably damaging alignment ? deleterious 0.995 0.0277 0.681 0.0521 NO NO ? +2.843 -1.117 -3.960 2 237 20 20 6q21 105 D 1.00 171 0.841 T L 56 1.23 0.86 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 7.471 ? 77.78 +P01112 105 D K ? P01112 105 D K ? ? probably damaging alignment ? deleterious 0.991 0.0326 0.711 0.0584 NO NO ? +2.461 -1.117 -3.578 2 237 20 20 6q21 105 D 1.00 171 0.841 T L 57 1.59 0.86 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 3.523 ? 77.78 +P01112 105 D L ? P01112 105 D L ? ? probably damaging alignment ? deleterious 0.983 0.0387 0.745 0.0657 NO NO ? +2.624 -1.117 -3.741 2 237 20 20 6q21 105 D 1.00 171 0.841 T L 56 1.3 0.86 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 5.915 ? 77.78 +P01112 105 D M ? P01112 105 D M ? ? probably damaging alignment ? deleterious 0.999 0.00574 0.136 0.0192 NO NO ? +3.786 -1.117 -4.903 2 237 20 20 6q21 105 D 1.00 171 0.841 T L 52 1.3 0.86 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.443 ? 77.78 +P01112 105 D N ? P01112 105 D N G A possibly damaging alignment ? deleterious 0.914 0.0603 0.813 0.0913 NO NO ? +2.319 -1.117 -3.436 2 237 20 20 6q21 105 D 1.00 171 0.841 T L 3 0.14 0.86 ? ? ? ? ? ? ? 0 0 0 -23 PF00071.17 4.243 ? 77.78 +P01112 105 D P ? P01112 105 D P ? ? possibly damaging alignment ? deleterious 0.933 0.0573 0.804 0.0882 NO NO ? +2.727 -1.117 -3.844 2 237 20 20 6q21 105 D 1.00 171 0.841 T L 1 0.23 0.86 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.417 ? 77.78 +P01112 105 D Q ? P01112 105 D Q ? ? probably damaging alignment ? deleterious 0.977 0.0424 0.758 0.0704 NO NO ? +2.716 -1.117 -3.833 2 237 20 20 6q21 105 D 1.00 171 0.841 T L 33 0.11 0.86 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 3.112 ? 77.78 +P01112 105 D R ? P01112 105 D R ? ? probably damaging alignment ? deleterious 0.998 0.0112 0.273 0.0274 NO NO ? +2.847 -1.117 -3.964 2 237 20 20 6q21 105 D 1.00 171 0.841 T L 62 0.45 0.86 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 3.681 ? 77.78 +P01112 105 D S ? P01112 105 D S ? ? probably damaging alignment ? deleterious 0.969 0.045 0.77 0.0734 NO NO ? +2.214 -1.117 -3.331 2 237 20 20 6q21 105 D 1.00 171 0.841 T L -22 0.48 0.86 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 3.279 ? 77.78 +P01112 105 D T ? P01112 105 D T ? ? probably damaging alignment ? deleterious 0.966 0.0465 0.775 0.0751 NO NO ? +2.458 -1.117 -3.575 2 237 20 20 6q21 105 D 1.00 171 0.841 T L 5 0.53 0.86 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.272 ? 77.78 +P01112 105 D V ? P01112 105 D V A T possibly damaging alignment ? deleterious 0.682 0.0841 0.862 0.117 NO NO ? +1.739 -1.117 -2.856 2 237 20 20 6q21 105 D 1.00 171 0.841 T L 29 1.19 0.86 ? ? ? ? ? ? ? 1 1 0 -24 PF00071.17 12.251 12.251 77.78 +P01112 105 D W ? P01112 105 D W ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +4.377 -1.117 -5.494 2 237 20 20 6q21 105 D 1.00 171 0.841 T L 116 1.22 0.86 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 0.450 ? 77.78 +P01112 105 D Y ? P01112 105 D Y G T probably damaging alignment ? deleterious 0.997 0.0167 0.409 0.0357 NO NO ? +3.130 -1.117 -4.247 2 237 20 20 6q21 105 D 1.00 171 0.841 T L 82 0.96 0.86 ? ? ? ? ? ? ? 1 0 0 -23 PF00071.17 4.514 ? 77.78 +P01112 106 S A ? P01112 106 S A T G benign alignment ? neutral 0 1 1 0.575 NO NO ? -0.028 -2.051 -2.023 2 238 20 20 6q21 106 D 1.00 171 0.384 . b -1 0.27 0.05 ? ? ? ? ? ? ? 1 0 2 -26 PF00071.17 22.836 22.836 78.84 +P01112 106 S C ? P01112 106 S C ? ? benign alignment ? neutral 0.018 0.202 0.953 0.223 NO NO ? +1.112 -2.051 -3.163 2 238 20 20 6q21 106 D 1.00 171 0.384 . b 19 0.73 0.05 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 32.987 32.987 78.84 +P01112 106 S D ? P01112 106 S D ? ? benign alignment ? neutral 0.351 0.109 0.899 0.141 NO NO ? +1.685 -2.051 -3.736 2 238 20 20 6q21 106 D 1.00 171 0.384 . b 22 0.48 0.05 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 6.034 ? 78.84 +P01112 106 S E ? P01112 106 S E ? ? benign alignment ? neutral 0.011 0.222 0.959 0.239 NO NO ? +0.942 -2.051 -2.993 2 238 20 20 6q21 106 D 1.00 171 0.384 . b 49 0.77 0.05 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 19.804 19.804 78.84 +P01112 106 S F ? P01112 106 S F ? ? possibly damaging alignment ? deleterious 0.934 0.0572 0.803 0.088 NO NO ? +2.234 -2.051 -4.285 2 238 20 20 6q21 106 D 1.00 171 0.384 . b 101 0.85 0.05 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.955 ? 78.84 +P01112 106 S G ? P01112 106 S G ? ? possibly damaging alignment ? deleterious 0.5 0.0966 0.884 0.129 NO NO ? +1.414 -2.051 -3.465 2 238 20 20 6q21 106 D 1.00 171 0.384 . b -29 0.02 0.05 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 6.178 ? 78.84 +P01112 106 S H ? P01112 106 S H ? ? probably damaging alignment ? deleterious 0.991 0.0326 0.711 0.0584 NO NO ? +2.748 -2.051 -4.799 2 238 20 20 6q21 106 D 1.00 171 0.384 . b 64 0.1 0.05 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.237 ? 78.84 +P01112 106 S I ? P01112 106 S I ? ? possibly damaging alignment ? neutral 0.455 0.0995 0.889 0.132 NO NO ? +1.033 -2.051 -3.084 2 238 20 20 6q21 106 D 1.00 171 0.384 . b 78 0.75 0.05 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 12.423 12.212 78.84 +P01112 106 S K ? P01112 106 S K ? ? benign alignment ? neutral 0.111 0.143 0.928 0.172 NO NO ? +0.728 -2.051 -2.779 2 238 20 20 6q21 106 D 1.00 171 0.384 . b 79 2.07 0.05 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 18.472 18.472 78.84 +P01112 106 S L ? P01112 106 S L C T benign alignment ? neutral 0.051 0.165 0.941 0.192 NO NO ? +0.470 -2.051 -2.521 2 238 20 20 6q21 106 D 1.00 171 0.384 . b 78 0.82 0.05 ? ? ? ? ? ? ? 0 1 1 -27 PF00071.17 20.266 20.266 78.84 +P01112 106 S M ? P01112 106 S M ? ? possibly damaging alignment ? deleterious 0.934 0.0572 0.803 0.088 NO NO ? +2.558 -2.051 -4.609 2 238 20 20 6q21 106 D 1.00 171 0.384 . b 74 0.82 0.05 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.690 ? 78.84 +P01112 106 S N ? P01112 106 S N ? ? benign alignment ? neutral 0.001 0.852 0.994 0.514 NO NO ? +0.816 -2.051 -2.867 2 238 20 20 6q21 106 D 1.00 171 0.384 . b 25 0.34 0.05 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 22.120 22.120 78.84 +P01112 106 S P ? P01112 106 S P T C possibly damaging alignment ? deleterious 0.853 0.0672 0.832 0.0986 NO NO ? +1.970 -2.051 -4.021 2 238 20 20 6q21 106 D 1.00 171 0.384 . b 23 0.25 0.05 ? ? ? ? ? ? ? 0 0 0 -26 PF00071.17 2.291 ? 78.84 +P01112 106 S Q ? P01112 106 S Q ? ? benign alignment ? neutral 0.223 0.122 0.913 0.153 NO NO ? +1.171 -2.051 -3.222 2 238 20 20 6q21 106 D 1.00 171 0.384 . b 55 0.37 0.05 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 13.809 13.809 78.84 +P01112 106 S R ? P01112 106 S R ? ? benign alignment ? neutral 0.063 0.16 0.937 0.187 NO NO ? +1.102 -2.051 -3.153 2 238 20 20 6q21 106 D 1.00 171 0.384 . b 84 0.93 0.05 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 22.572 22.572 78.84 +P01112 106 S T ? P01112 106 S T T A benign alignment ? neutral 0.001 0.852 0.994 0.514 NO NO ? +0.214 -2.051 -2.265 2 238 20 20 6q21 106 D 1.00 171 0.384 . b 27 0.05 0.05 ? ? ? ? ? ? ? 1 0 0 -26 PF00071.17 17.565 17.565 78.84 +P01112 106 S V ? P01112 106 S V ? ? benign alignment ? neutral 0.005 0.26 0.968 0.267 NO NO ? +0.671 -2.051 -2.722 2 238 20 20 6q21 106 D 1.00 171 0.384 . b 51 0.71 0.05 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 20.370 20.370 78.84 +P01112 106 S W ? P01112 106 S W C G probably damaging alignment ? deleterious 0.998 0.0112 0.273 0.0274 NO NO ? +3.459 -2.051 -5.510 2 238 20 20 6q21 106 D 1.00 171 0.384 . b 138 0.74 0.05 ? ? ? ? ? ? ? 1 1 1 -27 PF00071.17 0.428 ? 78.84 +P01112 106 S Y ? P01112 106 S Y ? ? probably damaging alignment ? deleterious 0.966 0.0465 0.775 0.0751 NO NO ? +2.308 -2.051 -4.359 2 238 20 20 6q21 106 D 1.00 171 0.384 . b 104 0.48 0.05 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.607 ? 78.84 +P01112 107 D A ? P01112 107 D A A C possibly damaging alignment ? deleterious 0.567 0.0939 0.877 0.127 NO NO ? +1.858 -1.402 -3.260 2 238 20 20 6q21 107 D 1.00 171 0.750 S A -23 0.75 0.69 ? ? ? ? ? ? ? 1 1 0 -30 PF00071.17 8.266 ? 85.71 +P01112 107 D C ? P01112 107 D C ? ? probably damaging alignment ? deleterious 0.959 0.0488 0.782 0.0779 NO NO ? +3.817 -1.402 -5.219 2 238 20 20 6q21 107 D 1.00 171 0.750 S A -3 1.21 0.69 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.379 ? 85.71 +P01112 107 D E ? P01112 107 D E T G benign alignment ? neutral 0 1 1 0.575 NO NO ? +0.573 -1.402 -1.975 2 238 20 20 6q21 107 D 1.00 171 0.750 S A 27 0.29 0.69 ? ? ? ? ? ? ? 1 2 0 -31 PF00071.17 25.462 25.462 85.71 +P01112 107 D F ? P01112 107 D F ? ? probably damaging alignment ? deleterious 0.997 0.0167 0.409 0.0357 NO NO ? +3.022 -1.402 -4.424 2 238 20 20 6q21 107 D 1.00 171 0.750 S A 79 1.33 0.69 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.579 ? 85.71 +P01112 107 D G ? P01112 107 D G A G benign alignment ? neutral 0.009 0.233 0.961 0.247 NO NO ? +1.217 -1.402 -2.619 2 238 20 20 6q21 107 D 1.00 171 0.750 S A -51 0.46 0.69 ? ? ? ? ? ? ? 0 1 0 -30 PF00071.17 33.181 33.181 85.71 +P01112 107 D H ? P01112 107 D H G C probably damaging alignment ? deleterious 0.964 0.0472 0.777 0.0761 NO NO ? +3.114 -1.402 -4.516 2 238 20 20 6q21 107 D 1.00 171 0.750 S A 42 0.58 0.69 ? ? ? ? ? ? ? 1 0 0 -29 PF00071.17 2.305 ? 85.71 +P01112 107 D I ? P01112 107 D I ? ? probably damaging alignment ? deleterious 0.99 0.0338 0.719 0.06 NO NO ? +2.752 -1.402 -4.154 2 238 20 20 6q21 107 D 1.00 171 0.750 S A 56 1.23 0.69 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.277 ? 85.71 +P01112 107 D K ? P01112 107 D K ? ? benign alignment ? neutral 0.423 0.103 0.892 0.135 NO NO ? +1.143 -1.402 -2.545 2 238 20 20 6q21 107 D 1.00 171 0.750 S A 57 1.59 0.69 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 12.754 12.754 85.71 +P01112 107 D L ? P01112 107 D L ? ? possibly damaging alignment ? deleterious 0.926 0.0582 0.807 0.089 NO NO ? +2.383 -1.402 -3.785 2 238 20 20 6q21 107 D 1.00 171 0.750 S A 56 1.3 0.69 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 3.210 ? 85.71 +P01112 107 D M ? P01112 107 D M ? ? probably damaging alignment ? deleterious 0.991 0.0326 0.711 0.0584 NO NO ? +3.504 -1.402 -4.906 2 238 20 20 6q21 107 D 1.00 171 0.750 S A 52 1.3 0.69 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.132 ? 85.71 +P01112 107 D N ? P01112 107 D N G A benign alignment ? neutral 0.002 0.704 0.987 0.452 NO NO ? +0.964 -1.402 -2.366 2 238 20 20 6q21 107 D 1.00 171 0.750 S A 3 0.14 0.69 ? ? ? ? ? ? ? 0 0 0 -29 PF00071.17 22.791 22.791 85.71 +P01112 107 D P ? P01112 107 D P ? ? benign alignment ? neutral 0.333 0.111 0.902 0.143 NO NO ? +2.454 -1.402 -3.856 2 238 20 20 6q21 107 D 1.00 171 0.750 S A 1 0.23 0.69 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.244 ? 85.71 +P01112 107 D Q ? P01112 107 D Q ? ? possibly damaging alignment ? deleterious 0.699 0.0824 0.859 0.115 NO NO ? +2.330 -1.402 -3.732 2 238 20 20 6q21 107 D 1.00 171 0.750 S A 33 0.11 0.69 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 5.585 ? 85.71 +P01112 107 D R ? P01112 107 D R ? ? possibly damaging alignment ? deleterious 0.861 0.0665 0.83 0.0979 NO NO ? +2.394 -1.402 -3.796 2 238 20 20 6q21 107 D 1.00 171 0.750 S A 62 0.45 0.69 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 4.934 ? 85.71 +P01112 107 D S ? P01112 107 D S ? ? benign alignment ? neutral 0.03 0.182 0.947 0.206 NO NO ? +0.928 -1.402 -2.330 2 238 20 20 6q21 107 D 1.00 171 0.750 S A -22 0.48 0.69 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 16.640 16.640 85.71 +P01112 107 D T ? P01112 107 D T ? ? benign alignment ? neutral 0.436 0.102 0.891 0.134 NO NO ? +2.096 -1.402 -3.498 2 238 20 20 6q21 107 D 1.00 171 0.750 S A 5 0.53 0.69 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 6.214 ? 85.71 +P01112 107 D V ? P01112 107 D V A T possibly damaging alignment ? deleterious 0.621 0.09 0.87 0.123 NO NO ? +2.415 -1.402 -3.817 2 238 20 20 6q21 107 D 1.00 171 0.750 S A 29 1.19 0.69 ? ? ? ? ? ? ? 1 1 0 -30 PF00071.17 3.118 ? 85.71 +P01112 107 D W ? P01112 107 D W ? ? probably damaging alignment ? deleterious 0.997 0.0167 0.409 0.0357 NO NO ? +4.178 -1.402 -5.580 2 238 20 20 6q21 107 D 1.00 171 0.750 S A 116 1.22 0.69 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 0.418 ? 85.71 +P01112 107 D Y ? P01112 107 D Y G T probably damaging alignment ? deleterious 0.995 0.0277 0.681 0.0521 NO NO ? +3.021 -1.402 -4.423 2 238 20 20 6q21 107 D 1.00 171 0.750 S A 82 0.96 0.69 ? ? ? ? ? ? ? 1 0 0 -29 PF00071.17 1.374 ? 85.71 +P01112 108 D A ? P01112 108 D A A C benign alignment ? neutral 0.086 0.151 0.932 0.18 NO NO ? +1.168 -2.108 -3.276 2 239 20 20 6q21 108 D 1.00 171 0.530 . b -23 0.75 0.47 ? ? ? ? ? ? ? 1 1 0 -33 PF00071.17 8.844 ? 80.95 +P01112 108 D C ? P01112 108 D C ? ? benign alignment ? neutral 0.007 0.246 0.965 0.257 NO NO ? +1.430 -2.108 -3.538 2 239 20 20 6q21 108 D 1.00 171 0.530 . b -3 1.21 0.47 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 21.736 21.736 80.95 +P01112 108 D E ? P01112 108 D E C G benign alignment ? neutral 0 1 1 0.575 NO NO ? +0.274 -2.108 -2.382 2 239 20 20 6q21 108 D 1.00 171 0.530 . b 27 0.29 0.47 ? ? ? ? ? ? ? 1 2 1 -34 PF00071.17 23.419 23.419 80.95 +P01112 108 D F ? P01112 108 D F ? ? possibly damaging alignment ? deleterious 0.884 0.0642 0.823 0.0956 NO NO ? +2.334 -2.108 -4.442 2 239 20 20 6q21 108 D 1.00 171 0.530 . b 79 1.33 0.47 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.654 ? 80.95 +P01112 108 D G ? P01112 108 D G A G benign alignment ? neutral 0.002 0.704 0.987 0.452 NO NO ? +0.759 -2.108 -2.867 2 239 20 20 6q21 108 D 1.00 171 0.530 . b -51 0.46 0.47 ? ? ? ? ? ? ? 0 1 0 -33 PF00071.17 33.181 33.181 80.95 +P01112 108 D H ? P01112 108 D H G C benign alignment ? neutral 0.042 0.172 0.943 0.198 NO NO ? +1.004 -2.108 -3.112 2 239 20 20 6q21 108 D 1.00 171 0.530 . b 42 0.58 0.47 ? ? ? ? ? ? ? 1 0 0 -32 PF00071.17 17.421 17.421 80.95 +P01112 108 D I ? P01112 108 D I ? ? possibly damaging alignment ? deleterious 0.792 0.0733 0.846 0.105 NO NO ? +1.968 -2.108 -4.076 2 239 20 20 6q21 108 D 1.00 171 0.530 . b 56 1.23 0.47 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 12.336 ? 80.95 +P01112 108 D K ? P01112 108 D K ? ? benign alignment ? neutral 0.028 0.185 0.948 0.209 NO NO ? +0.446 -2.108 -2.554 2 239 20 20 6q21 108 D 1.00 171 0.530 . b 57 1.59 0.47 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 18.472 18.472 80.95 +P01112 108 D L ? P01112 108 D L ? ? possibly damaging alignment ? deleterious 0.521 0.096 0.882 0.129 NO NO ? +1.564 -2.108 -3.672 2 239 20 20 6q21 108 D 1.00 171 0.530 . b 56 1.3 0.47 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 9.766 ? 80.95 +P01112 108 D M ? P01112 108 D M ? ? possibly damaging alignment ? deleterious 0.852 0.0673 0.833 0.0987 NO NO ? +2.722 -2.108 -4.830 2 239 20 20 6q21 108 D 1.00 171 0.530 . b 52 1.3 0.47 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.383 ? 80.95 +P01112 108 D N ? P01112 108 D N G A benign alignment ? neutral 0.001 0.852 0.994 0.514 NO NO ? +0.901 -2.108 -3.009 2 239 20 20 6q21 108 D 1.00 171 0.530 . b 3 0.14 0.47 ? ? ? ? ? ? ? 0 0 0 -32 PF00071.17 25.137 25.137 80.95 +P01112 108 D P ? P01112 108 D P ? ? benign alignment ? neutral 0.001 0.852 0.994 0.514 NO NO ? +1.022 -2.108 -3.130 2 239 20 20 6q21 108 D 1.00 171 0.530 . b 1 0.23 0.47 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 22.512 22.512 80.95 +P01112 108 D Q ? P01112 108 D Q ? ? benign alignment ? neutral 0.055 0.163 0.94 0.191 NO NO ? +1.034 -2.108 -3.142 2 239 20 20 6q21 108 D 1.00 171 0.530 . b 33 0.11 0.47 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 17.092 17.092 80.95 +P01112 108 D R ? P01112 108 D R ? ? benign alignment ? neutral 0.003 0.556 0.981 0.39 NO NO ? +0.271 -2.108 -2.379 2 239 20 20 6q21 108 D 1.00 171 0.530 . b 62 0.45 0.47 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 22.936 22.936 80.95 +P01112 108 D S ? P01112 108 D S ? ? benign alignment ? neutral 0.003 0.556 0.981 0.39 NO NO ? +0.313 -2.108 -2.421 2 239 20 20 6q21 108 D 1.00 171 0.530 . b -22 0.48 0.47 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 17.803 17.803 80.95 +P01112 108 D T ? P01112 108 D T ? ? benign alignment ? neutral 0.004 0.408 0.975 0.328 NO NO ? +0.657 -2.108 -2.765 2 239 20 20 6q21 108 D 1.00 171 0.530 . b 5 0.53 0.47 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 15.613 15.613 80.95 +P01112 108 D V ? P01112 108 D V A T benign alignment ? neutral 0.002 0.704 0.987 0.452 NO NO ? +0.982 -2.108 -3.090 2 239 20 20 6q21 108 D 1.00 171 0.530 . b 29 1.19 0.47 ? ? ? ? ? ? ? 1 1 0 -33 PF00071.17 20.228 20.228 80.95 +P01112 108 D W ? P01112 108 D W ? ? probably damaging alignment ? deleterious 0.994 0.0289 0.689 0.0537 NO NO ? +3.452 -2.108 -5.560 2 239 20 20 6q21 108 D 1.00 171 0.530 . b 116 1.22 0.47 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 0.530 ? 80.95 +P01112 108 D Y ? P01112 108 D Y G T possibly damaging alignment ? deleterious 0.852 0.0673 0.833 0.0987 NO NO ? +2.243 -2.108 -4.351 2 239 20 20 6q21 108 D 1.00 171 0.530 . b 82 0.96 0.47 ? ? ? ? ? ? ? 1 0 0 -32 PF00071.17 2.856 ? 80.95 +P01112 109 V A ? P01112 109 V A T C possibly damaging alignment ? deleterious 0.856 0.067 0.832 0.0984 NO NO ? +1.316 -1.183 -2.499 2 239 20 20 6q21 109 D 1.00 171 0.025 . B -52 0.44 -0.28 ? ? ? ? ? ? ? 0 1 2 -36 PF00071.17 14.713 14.713 75.66 +P01112 109 V C ? P01112 109 V C ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.600 -1.183 -4.783 2 239 20 20 6q21 109 D 1.00 171 0.025 . B -32 0.02 -0.28 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.379 ? 75.66 +P01112 109 V D ? P01112 109 V D ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.779 -1.183 -3.962 2 239 20 20 6q21 109 D 1.00 171 0.025 . B -29 1.19 -0.28 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 3.706 ? 75.66 +P01112 109 V E ? P01112 109 V E T A probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.594 -1.183 -3.777 2 239 20 20 6q21 109 D 1.00 171 0.025 . B -2 1.48 -0.28 ? ? ? ? ? ? ? 1 1 0 -36 PF00071.17 3.905 ? 75.66 +P01112 109 V F ? P01112 109 V F ? ? probably damaging alignment ? deleterious 0.989 0.0346 0.723 0.0608 NO NO ? +1.434 -1.183 -2.617 2 239 20 20 6q21 109 D 1.00 171 0.025 . B 50 0.14 -0.28 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 18.967 18.967 75.66 +P01112 109 V G ? P01112 109 V G T G probably damaging alignment ? deleterious 0.998 0.0112 0.273 0.0274 NO NO ? +2.416 -1.183 -3.599 2 239 20 20 6q21 109 D 1.00 171 0.025 . B -80 0.73 -0.28 ? ? ? ? ? ? ? 1 1 0 -36 PF00071.17 5.069 ? 75.66 +P01112 109 V H ? P01112 109 V H ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.609 -1.183 -4.792 2 239 20 20 6q21 109 D 1.00 171 0.025 . B 13 0.61 -0.28 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.394 ? 75.66 +P01112 109 V I ? P01112 109 V I ? ? benign alignment ? neutral 0.044 0.17 0.942 0.197 NO NO ? +1.160 -1.183 -2.343 2 239 20 20 6q21 109 D 1.00 171 0.025 . B 27 0.04 -0.28 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 19.826 19.826 75.66 +P01112 109 V K ? P01112 109 V K ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.611 -1.183 -3.794 2 239 20 20 6q21 109 D 1.00 171 0.025 . B 28 2.78 -0.28 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 4.101 ? 75.66 +P01112 109 V L ? P01112 109 V L G C probably damaging alignment ? deleterious 0.977 0.0424 0.758 0.0704 NO NO ? +1.714 -1.183 -2.897 2 239 20 20 6q21 109 D 1.00 171 0.025 . B 27 0.11 -0.28 ? ? ? ? ? ? ? 1 0 1 -35 PF00071.17 12.237 ? 75.66 +P01112 109 V M ? P01112 109 V M G A probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.080 -1.183 -4.263 2 239 20 20 6q21 109 D 1.00 171 0.025 . B 23 0.11 -0.28 ? ? ? ? ? ? ? 0 0 1 -35 PF00071.17 2.696 ? 75.66 +P01112 109 V N ? P01112 109 V N ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.934 -1.183 -4.117 2 239 20 20 6q21 109 D 1.00 171 0.025 . B -26 1.05 -0.28 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 4.160 ? 75.66 +P01112 109 V P ? P01112 109 V P ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.864 -1.183 -4.047 2 239 20 20 6q21 109 D 1.00 171 0.025 . B -28 0.96 -0.28 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.203 ? 75.66 +P01112 109 V Q ? P01112 109 V Q ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.035 -1.183 -4.218 2 239 20 20 6q21 109 D 1.00 171 0.025 . B 4 1.08 -0.28 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.503 ? 75.66 +P01112 109 V R ? P01112 109 V R ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.006 -1.183 -4.189 2 239 20 20 6q21 109 D 1.00 171 0.025 . B 33 1.64 -0.28 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.996 ? 75.66 +P01112 109 V S ? P01112 109 V S ? ? possibly damaging alignment ? deleterious 0.95 0.0527 0.791 0.0828 NO NO ? +1.631 -1.183 -2.814 2 239 20 20 6q21 109 D 1.00 171 0.025 . B -51 0.71 -0.28 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 16.640 16.640 75.66 +P01112 109 V T ? P01112 109 V T ? ? probably damaging alignment ? deleterious 0.987 0.036 0.731 0.0626 NO NO ? +2.213 -1.183 -3.396 2 239 20 20 6q21 109 D 1.00 171 0.025 . B -24 0.66 -0.28 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 6.214 ? 75.66 +P01112 109 V W ? P01112 109 V W ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.997 -1.183 -5.180 2 239 20 20 6q21 109 D 1.00 171 0.025 . B 87 0.03 -0.28 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.396 ? 75.66 +P01112 109 V Y ? P01112 109 V Y ? ? probably damaging alignment ? deleterious 0.972 0.0442 0.766 0.0725 NO NO ? +1.713 -1.183 -2.896 2 239 20 20 6q21 109 D 1.00 171 0.025 . B 53 0.23 -0.28 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 16.122 16.122 75.66 +P01112 110 P A ? P01112 110 P A C G probably damaging alignment ? deleterious 0.999 0.00574 0.136 0.0192 NO NO ? +2.322 -0.847 -3.169 2 239 20 20 6q21 110 D 1.00 171 0.030 . b -24 0.52 -0.53 ? ? ? ? ? ? ? 1 0 0 -38 PF00071.17 3.569 ? 79.89 +P01112 110 P C ? P01112 110 P C ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +4.262 -0.847 -5.109 2 239 20 20 6q21 110 D 1.00 171 0.030 . b -4 0.98 -0.53 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.267 ? 79.89 +P01112 110 P D ? P01112 110 P D ? ? possibly damaging alignment ? deleterious 0.652 0.0875 0.866 0.12 NO NO ? +1.781 -0.847 -2.628 2 239 20 20 6q21 110 D 1.00 171 0.030 . b -1 0.23 -0.53 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 30.016 30.016 79.89 +P01112 110 P E ? P01112 110 P E ? ? probably damaging alignment ? deleterious 0.992 0.0314 0.704 0.0568 NO NO ? +2.612 -0.847 -3.459 2 239 20 20 6q21 110 D 1.00 171 0.030 . b 26 0.52 -0.53 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 6.936 ? 79.89 +P01112 110 P F ? P01112 110 P F ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.597 -0.847 -4.444 2 239 20 20 6q21 110 D 1.00 171 0.030 . b 78 1.1 -0.53 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 4.374 ? 79.89 +P01112 110 P G ? P01112 110 P G ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.594 -0.847 -3.441 2 239 20 20 6q21 110 D 1.00 171 0.030 . b -52 0.23 -0.53 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 3.558 ? 79.89 +P01112 110 P H ? P01112 110 P H C A probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.901 -0.847 -4.748 2 239 20 20 6q21 110 D 1.00 171 0.030 . b 41 0.35 -0.53 ? ? ? ? ? ? ? 1 1 0 -39 PF00071.17 1.346 ? 79.89 +P01112 110 P I ? P01112 110 P I ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.062 -0.847 -3.909 2 239 20 20 6q21 110 D 1.00 171 0.030 . b 55 1 -0.53 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 9.194 ? 79.89 +P01112 110 P K ? P01112 110 P K ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.702 -0.847 -3.549 2 239 20 20 6q21 110 D 1.00 171 0.030 . b 56 1.82 -0.53 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 3.450 ? 79.89 +P01112 110 P L ? P01112 110 P L C T probably damaging structure 1.1.1 deleterious 0.999 0.00574 0.136 0.0192 NO NO ? +1.829 -0.847 -2.676 2 239 20 20 6q21 110 D 1.00 171 0.030 . b 55 1.07 -0.53 ? ? ? ? ? ? ? 0 1 0 -39 PF00071.17 30.002 30.002 79.89 +P01112 110 P M ? P01112 110 P M ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.822 -0.847 -4.669 2 239 20 20 6q21 110 D 1.00 171 0.030 . b 51 1.07 -0.53 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 3.982 ? 79.89 +P01112 110 P N ? P01112 110 P N ? ? probably damaging alignment ? deleterious 0.999 0.00574 0.136 0.0192 NO NO ? +3.056 -0.847 -3.903 2 239 20 20 6q21 110 D 1.00 171 0.030 . b 2 0.09 -0.53 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 5.249 ? 79.89 +P01112 110 P Q ? P01112 110 P Q ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.121 -0.847 -3.968 2 239 20 20 6q21 110 D 1.00 171 0.030 . b 32 0.12 -0.53 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.325 ? 79.89 +P01112 110 P R ? P01112 110 P R C G probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.159 -0.847 -4.006 2 239 20 20 6q21 110 D 1.00 171 0.030 . b 61 0.68 -0.53 ? ? ? ? ? ? ? 1 1 2 -39 PF00071.17 2.238 ? 79.89 +P01112 110 P S ? P01112 110 P S C T probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.607 -0.847 -3.454 2 239 20 20 6q21 110 D 1.00 171 0.030 . b -23 0.25 -0.53 ? ? ? ? ? ? ? 0 0 0 -38 PF00071.17 3.956 ? 79.89 +P01112 110 P T ? P01112 110 P T C A probably damaging alignment ? deleterious 0.999 0.00574 0.136 0.0192 NO NO ? +2.647 -0.847 -3.494 2 239 20 20 6q21 110 D 1.00 171 0.030 . b 4 0.3 -0.53 ? ? ? ? ? ? ? 1 0 0 -38 PF00071.17 2.685 ? 79.89 +P01112 110 P V ? P01112 110 P V ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.687 -0.847 -3.534 2 239 20 20 6q21 110 D 1.00 171 0.030 . b 28 0.96 -0.53 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 7.656 ? 79.89 +P01112 110 P W ? P01112 110 P W ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +4.723 -0.847 -5.570 2 239 20 20 6q21 110 D 1.00 171 0.030 . b 115 0.99 -0.53 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 0.591 ? 79.89 +P01112 110 P Y ? P01112 110 P Y ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.563 -0.847 -4.410 2 239 20 20 6q21 110 D 1.00 171 0.030 . b 81 0.73 -0.53 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.785 ? 79.89 +P01112 111 M A ? P01112 111 M A ? ? probably damaging alignment ? deleterious 0.992 0.0314 0.704 0.0568 NO NO ? +1.675 -1.553 -3.228 2 239 20 20 6q21 111 D 1.00 171 0.013 E B -75 0.55 -0.74 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 4.354 ? 78.84 +P01112 111 M C ? P01112 111 M C ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.313 -1.553 -4.866 2 239 20 20 6q21 111 D 1.00 171 0.013 E B -55 0.09 -0.74 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.272 ? 78.84 +P01112 111 M D ? P01112 111 M D ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.497 -1.553 -4.050 2 239 20 20 6q21 111 D 1.00 171 0.013 E B -52 1.3 -0.74 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 3.181 ? 78.84 +P01112 111 M E ? P01112 111 M E ? ? probably damaging alignment ? deleterious 0.999 0.00574 0.136 0.0192 NO NO ? +2.242 -1.553 -3.795 2 239 20 20 6q21 111 D 1.00 171 0.013 E B -25 1.59 -0.74 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 5.376 ? 78.84 +P01112 111 M F ? P01112 111 M F ? ? benign alignment ? neutral 0.085 0.151 0.932 0.18 NO NO ? +1.148 -1.553 -2.701 2 239 20 20 6q21 111 D 1.00 171 0.013 E B 27 0.03 -0.74 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 20.802 20.802 78.84 +P01112 111 M G ? P01112 111 M G ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.206 -1.553 -3.759 2 239 20 20 6q21 111 D 1.00 171 0.013 E B -103 0.84 -0.74 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 3.304 ? 78.84 +P01112 111 M H ? P01112 111 M H ? ? probably damaging alignment ? deleterious 0.999 0.00574 0.136 0.0192 NO NO ? +3.284 -1.553 -4.837 2 239 20 20 6q21 111 D 1.00 171 0.013 E B -10 0.72 -0.74 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.717 ? 78.84 +P01112 111 M I ? P01112 111 M I G C benign alignment ? neutral 0.108 0.143 0.928 0.173 NO NO ? +0.790 -1.553 -2.343 2 239 20 20 6q21 111 D 1.00 171 0.013 E B 4 0.07 -0.74 ? ? ? ? ? ? ? 1 2 2 -43 PF00071.17 21.406 21.406 78.84 +P01112 111 M K ? P01112 111 M K T A possibly damaging structure 1.1.1 deleterious 0.896 0.063 0.82 0.0944 NO NO ? +1.317 -1.553 -2.870 2 239 20 20 6q21 111 D 1.00 171 0.013 E B 5 2.89 -0.74 ? ? ? ? ? ? ? 1 1 0 -42 PF00071.17 20.964 20.964 78.84 +P01112 111 M L ? P01112 111 M L A C benign alignment ? neutral 0.05 0.166 0.941 0.193 NO NO ? +0.681 -1.553 -2.234 2 239 20 20 6q21 111 D 1.00 171 0.013 E B 4 0 -0.74 ? ? ? ? ? ? ? 1 0 0 -41 PF00071.17 25.829 25.829 78.84 +P01112 111 M N ? P01112 111 M N ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.525 -1.553 -4.078 2 239 20 20 6q21 111 D 1.00 171 0.013 E B -49 1.16 -0.74 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 3.175 ? 78.84 +P01112 111 M P ? P01112 111 M P ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.554 -1.553 -4.107 2 239 20 20 6q21 111 D 1.00 171 0.013 E B -51 1.07 -0.74 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.052 ? 78.84 +P01112 111 M Q ? P01112 111 M Q ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.453 -1.553 -4.006 2 239 20 20 6q21 111 D 1.00 171 0.013 E B -19 1.19 -0.74 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 4.029 ? 78.84 +P01112 111 M R ? P01112 111 M R T G probably damaging structure 1.1.1 deleterious 0.978 0.0417 0.756 0.0695 NO NO ? +1.450 -1.553 -3.003 2 239 20 20 6q21 111 D 1.00 171 0.013 E B 10 1.75 -0.74 ? ? ? ? ? ? ? 1 1 0 -42 PF00071.17 24.574 24.574 78.84 +P01112 111 M S ? P01112 111 M S ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.071 -1.553 -3.624 2 239 20 20 6q21 111 D 1.00 171 0.013 E B -74 0.82 -0.74 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 4.035 ? 78.84 +P01112 111 M T ? P01112 111 M T T C probably damaging alignment ? deleterious 0.99 0.0338 0.719 0.06 NO NO ? +2.019 -1.553 -3.572 2 239 20 20 6q21 111 D 1.00 171 0.013 E B -47 0.77 -0.74 ? ? ? ? ? ? ? 0 1 2 -42 PF00071.17 3.129 ? 78.84 +P01112 111 M V ? P01112 111 M V A G benign alignment ? neutral 0.335 0.111 0.902 0.143 NO NO ? +0.682 -1.553 -2.235 2 239 20 20 6q21 111 D 1.00 171 0.013 E B -23 0.11 -0.74 ? ? ? ? ? ? ? 0 0 2 -41 PF00071.17 13.897 13.675 78.84 +P01112 111 M W ? P01112 111 M W ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.589 -1.553 -5.142 2 239 20 20 6q21 111 D 1.00 171 0.013 E B 64 0.08 -0.74 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 0.966 ? 78.84 +P01112 111 M Y ? P01112 111 M Y ? ? probably damaging alignment ? deleterious 0.992 0.0314 0.704 0.0568 NO NO ? +2.441 -1.553 -3.994 2 239 20 20 6q21 111 D 1.00 171 0.013 E B 30 0.34 -0.74 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 4.825 ? 78.84 +P01112 112 V A ? P01112 112 V A T C probably damaging alignment ? deleterious 0.996 0.0222 0.545 0.0439 NO NO ? +1.892 -1.119 -3.011 2 239 20 20 6q21 112 D 1.00 171 0.000 E B -52 0.44 -1.09 ? ? ? ? ? ? ? 0 1 2 -45 PF00071.17 5.528 ? 75.66 +P01112 112 V C ? P01112 112 V C ? ? probably damaging alignment ? deleterious 0.962 0.0478 0.779 0.0767 NO NO ? +1.971 -1.119 -3.090 2 239 20 20 6q21 112 D 1.00 171 0.000 E B -32 0.02 -1.09 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 28.384 28.384 75.66 +P01112 112 V D ? P01112 112 V D ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.866 -1.119 -3.985 2 239 20 20 6q21 112 D 1.00 171 0.000 E B -29 1.19 -1.09 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.819 ? 75.66 +P01112 112 V E ? P01112 112 V E T A probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.697 -1.119 -3.816 2 239 20 20 6q21 112 D 1.00 171 0.000 E B -2 1.48 -1.09 ? ? ? ? ? ? ? 1 1 0 -45 PF00071.17 3.047 ? 75.66 +P01112 112 V F ? P01112 112 V F ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.806 -1.119 -3.925 2 239 20 20 6q21 112 D 1.00 171 0.000 E B 50 0.14 -1.09 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 3.275 ? 75.66 +P01112 112 V G ? P01112 112 V G T G probably damaging alignment ? deleterious 0.999 0.00574 0.136 0.0192 NO NO ? +2.586 -1.119 -3.705 2 239 20 20 6q21 112 D 1.00 171 0.000 E B -80 0.73 -1.09 ? ? ? ? ? ? ? 1 1 0 -45 PF00071.17 3.250 ? 75.66 +P01112 112 V H ? P01112 112 V H ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.857 -1.119 -4.976 2 239 20 20 6q21 112 D 1.00 171 0.000 E B 13 0.61 -1.09 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.106 ? 75.66 +P01112 112 V I ? P01112 112 V I ? ? possibly damaging alignment ? deleterious 0.541 0.0949 0.88 0.128 NO NO ? +1.004 -1.119 -2.123 2 239 20 20 6q21 112 D 1.00 171 0.000 E B 27 0.04 -1.09 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 19.826 19.826 75.66 +P01112 112 V K ? P01112 112 V K ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.680 -1.119 -3.799 2 239 20 20 6q21 112 D 1.00 171 0.000 E B 28 2.78 -1.09 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 3.489 ? 75.66 +P01112 112 V L ? P01112 112 V L G C possibly damaging alignment ? deleterious 0.913 0.0604 0.813 0.0915 NO NO ? +1.671 -1.119 -2.790 2 239 20 20 6q21 112 D 1.00 171 0.000 E B 27 0.11 -1.09 ? ? ? ? ? ? ? 1 0 0 -44 PF00071.17 12.837 ? 75.66 +P01112 112 V M ? P01112 112 V M G A probably damaging alignment ? deleterious 0.997 0.0167 0.409 0.0357 NO NO ? +1.920 -1.119 -3.039 2 239 20 20 6q21 112 D 1.00 171 0.000 E B 23 0.11 -1.09 ? ? ? ? ? ? ? 0 0 0 -44 PF00071.17 10.541 10.541 75.66 +P01112 112 V N ? P01112 112 V N ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.023 -1.119 -4.142 2 239 20 20 6q21 112 D 1.00 171 0.000 E B -26 1.05 -1.09 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 3.324 ? 75.66 +P01112 112 V P ? P01112 112 V P ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.898 -1.119 -4.017 2 239 20 20 6q21 112 D 1.00 171 0.000 E B -28 0.96 -1.09 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.009 ? 75.66 +P01112 112 V Q ? P01112 112 V Q ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.098 -1.119 -4.217 2 239 20 20 6q21 112 D 1.00 171 0.000 E B 4 1.08 -1.09 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.051 ? 75.66 +P01112 112 V R ? P01112 112 V R ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.064 -1.119 -4.183 2 239 20 20 6q21 112 D 1.00 171 0.000 E B 33 1.64 -1.09 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.647 ? 75.66 +P01112 112 V S ? P01112 112 V S ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.493 -1.119 -3.612 2 239 20 20 6q21 112 D 1.00 171 0.000 E B -51 0.71 -1.09 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 6.988 ? 75.66 +P01112 112 V T ? P01112 112 V T ? ? probably damaging alignment ? deleterious 0.997 0.0167 0.409 0.0357 NO NO ? +1.521 -1.119 -2.640 2 239 20 20 6q21 112 D 1.00 171 0.000 E B -24 0.66 -1.09 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 18.606 18.606 75.66 +P01112 112 V W ? P01112 112 V W ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +4.233 -1.119 -5.352 2 239 20 20 6q21 112 D 1.00 171 0.000 E B 87 0.03 -1.09 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 0.518 ? 75.66 +P01112 112 V Y ? P01112 112 V Y ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.960 -1.119 -4.079 2 239 20 20 6q21 112 D 1.00 171 0.000 E B 53 0.23 -1.09 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.488 ? 75.66 +P01112 113 L A ? P01112 113 L A ? ? probably damaging alignment ? deleterious 0.999 0.00574 0.136 0.0192 NO NO ? +2.008 -1.185 -3.193 2 239 20 20 6q21 113 D 1.00 171 0.000 E B -79 0.55 -0.89 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 4.738 ? 75.66 +P01112 113 L C ? P01112 113 L C ? ? probably damaging alignment ? deleterious 0.988 0.0353 0.727 0.0617 NO NO ? +2.009 -1.185 -3.194 2 239 20 20 6q21 113 D 1.00 171 0.000 E B -59 0.09 -0.89 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 35.544 35.544 75.66 +P01112 113 L D ? P01112 113 L D ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.908 -1.185 -4.093 2 239 20 20 6q21 113 D 1.00 171 0.000 E B -56 1.3 -0.89 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.753 ? 75.66 +P01112 113 L E ? P01112 113 L E ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.724 -1.185 -3.909 2 239 20 20 6q21 113 D 1.00 171 0.000 E B -29 1.59 -0.89 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 3.945 ? 75.66 +P01112 113 L F ? P01112 113 L F ? ? probably damaging alignment ? deleterious 0.999 0.00574 0.136 0.0192 NO NO ? +2.680 -1.185 -3.865 2 239 20 20 6q21 113 D 1.00 171 0.000 E B 23 0.03 -0.89 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.797 ? 75.66 +P01112 113 L G ? P01112 113 L G ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.639 -1.185 -3.824 2 239 20 20 6q21 113 D 1.00 171 0.000 E B -107 0.84 -0.89 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.766 ? 75.66 +P01112 113 L H ? P01112 113 L H ? ? probably damaging alignment ? deleterious 0.999 0.00574 0.136 0.0192 NO NO ? +2.045 -1.185 -3.230 2 239 20 20 6q21 113 D 1.00 171 0.000 E B -14 0.72 -0.89 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 26.787 26.787 75.66 +P01112 113 L I ? P01112 113 L I ? ? possibly damaging alignment ? deleterious 0.761 0.0768 0.852 0.109 NO NO ? +1.245 -1.185 -2.430 2 239 20 20 6q21 113 D 1.00 171 0.000 E B 0 0.07 -0.89 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 13.792 13.792 75.66 +P01112 113 L K ? P01112 113 L K ? ? probably damaging alignment ? deleterious 0.999 0.00574 0.136 0.0192 NO NO ? +2.624 -1.185 -3.809 2 239 20 20 6q21 113 D 1.00 171 0.000 E B 1 2.89 -0.89 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 3.427 ? 75.66 +P01112 113 L M ? P01112 113 L M C A probably damaging alignment ? deleterious 0.989 0.0346 0.723 0.0608 NO NO ? +1.899 -1.185 -3.084 2 239 20 20 6q21 113 D 1.00 171 0.000 E B -4 0 -0.89 ? ? ? ? ? ? ? 1 0 0 -47 PF00071.17 9.513 9.513 75.66 +P01112 113 L N ? P01112 113 L N ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.957 -1.185 -4.142 2 239 20 20 6q21 113 D 1.00 171 0.000 E B -53 1.16 -0.89 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 4.128 ? 75.66 +P01112 113 L P ? P01112 113 L P T C probably damaging structure 1.1.1 deleterious 0.998 0.0112 0.273 0.0274 NO NO ? +1.780 -1.185 -2.965 2 239 20 20 6q21 113 D 1.00 171 0.000 E B -55 1.07 -0.89 ? ? ? ? ? ? ? 0 1 2 -48 PF00071.17 34.029 34.029 75.66 +P01112 113 L Q ? P01112 113 L Q T A probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.025 -1.185 -4.210 2 239 20 20 6q21 113 D 1.00 171 0.000 E B -23 1.19 -0.89 ? ? ? ? ? ? ? 1 1 0 -48 PF00071.17 3.028 ? 75.66 +P01112 113 L R ? P01112 113 L R T G probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.891 -1.185 -4.076 2 239 20 20 6q21 113 D 1.00 171 0.000 E B 6 1.75 -0.89 ? ? ? ? ? ? ? 1 1 2 -48 PF00071.17 3.581 ? 75.66 +P01112 113 L S ? P01112 113 L S ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.504 -1.185 -3.689 2 239 20 20 6q21 113 D 1.00 171 0.000 E B -78 0.82 -0.89 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 3.190 ? 75.66 +P01112 113 L T ? P01112 113 L T ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.369 -1.185 -3.554 2 239 20 20 6q21 113 D 1.00 171 0.000 E B -51 0.77 -0.89 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 3.328 ? 75.66 +P01112 113 L V ? P01112 113 L V C G possibly damaging alignment ? deleterious 0.76 0.0769 0.852 0.109 NO NO ? +1.168 -1.185 -2.353 2 239 20 20 6q21 113 D 1.00 171 0.000 E B -27 0.11 -0.89 ? ? ? ? ? ? ? 1 0 0 -47 PF00071.17 17.949 17.949 75.66 +P01112 113 L W ? P01112 113 L W ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +4.106 -1.185 -5.291 2 239 20 20 6q21 113 D 1.00 171 0.000 E B 60 0.08 -0.89 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 0.467 ? 75.66 +P01112 113 L Y ? P01112 113 L Y ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.870 -1.185 -4.055 2 239 20 20 6q21 113 D 1.00 171 0.000 E B 26 0.34 -0.89 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 4.391 ? 75.66 +P01112 114 V A ? P01112 114 V A T C possibly damaging alignment ? deleterious 0.691 0.0829 0.86 0.115 NO NO ? +1.307 -1.271 -2.578 2 239 20 20 6q21 114 D 1.00 171 0.000 E B -52 0.44 -1.04 ? ? ? ? ? ? ? 0 1 2 -51 PF00071.17 19.311 19.311 76.19 +P01112 114 V C ? P01112 114 V C ? ? probably damaging alignment ? deleterious 0.962 0.0478 0.779 0.0767 NO NO ? +1.964 -1.271 -3.235 2 239 20 20 6q21 114 D 1.00 171 0.000 E B -32 0.02 -1.04 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 23.270 23.270 76.19 +P01112 114 V D ? P01112 114 V D ? ? probably damaging structure 1.1.1 deleterious 0.998 0.0112 0.273 0.0274 NO NO ? +1.688 -1.271 -2.959 2 239 20 20 6q21 114 D 1.00 171 0.000 E B -29 1.19 -1.04 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 29.177 29.177 76.19 +P01112 114 V E ? P01112 114 V E T A probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.492 -1.271 -3.763 2 239 20 20 6q21 114 D 1.00 171 0.000 E B -2 1.48 -1.04 ? ? ? ? ? ? ? 1 1 0 -51 PF00071.17 6.742 ? 76.19 +P01112 114 V F ? P01112 114 V F ? ? possibly damaging alignment ? deleterious 0.93 0.0578 0.805 0.0887 NO NO ? +1.742 -1.271 -3.013 2 239 20 20 6q21 114 D 1.00 171 0.000 E B 50 0.14 -1.04 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 24.473 24.473 76.19 +P01112 114 V G ? P01112 114 V G T G probably damaging alignment ? deleterious 0.999 0.00574 0.136 0.0192 NO NO ? +2.388 -1.271 -3.659 2 239 20 20 6q21 114 D 1.00 171 0.000 E B -80 0.73 -1.04 ? ? ? ? ? ? ? 1 1 0 -51 PF00071.17 5.224 ? 76.19 +P01112 114 V H ? P01112 114 V H ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.681 -1.271 -4.952 2 239 20 20 6q21 114 D 1.00 171 0.000 E B 13 0.61 -1.04 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.308 ? 76.19 +P01112 114 V I ? P01112 114 V I ? ? possibly damaging alignment ? deleterious 0.541 0.0949 0.88 0.128 NO NO ? +1.009 -1.271 -2.280 2 239 20 20 6q21 114 D 1.00 171 0.000 E B 27 0.04 -1.04 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 20.688 20.688 76.19 +P01112 114 V K ? P01112 114 V K ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.558 -1.271 -3.829 2 239 20 20 6q21 114 D 1.00 171 0.000 E B 28 2.78 -1.04 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 3.354 ? 76.19 +P01112 114 V L ? P01112 114 V L G C possibly damaging alignment ? deleterious 0.782 0.0746 0.848 0.107 NO NO ? +1.667 -1.271 -2.938 2 239 20 20 6q21 114 D 1.00 171 0.000 E B 27 0.11 -1.04 ? ? ? ? ? ? ? 1 0 0 -50 PF00071.17 14.089 ? 76.19 +P01112 114 V M ? P01112 114 V M G A probably damaging alignment ? deleterious 0.997 0.0167 0.409 0.0357 NO NO ? +1.908 -1.271 -3.179 2 239 20 20 6q21 114 D 1.00 171 0.000 E B 23 0.11 -1.04 ? ? ? ? ? ? ? 0 0 0 -50 PF00071.17 11.569 11.569 76.19 +P01112 114 V N ? P01112 114 V N ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.880 -1.271 -4.151 2 239 20 20 6q21 114 D 1.00 171 0.000 E B -26 1.05 -1.04 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 5.102 ? 76.19 +P01112 114 V P ? P01112 114 V P ? ? probably damaging alignment ? deleterious 0.966 0.0465 0.775 0.0751 NO NO ? +1.696 -1.271 -2.967 2 239 20 20 6q21 114 D 1.00 171 0.000 E B -28 0.96 -1.04 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 37.432 37.432 76.19 +P01112 114 V Q ? P01112 114 V Q ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.962 -1.271 -4.233 2 239 20 20 6q21 114 D 1.00 171 0.000 E B 4 1.08 -1.04 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.260 ? 76.19 +P01112 114 V R ? P01112 114 V R ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.948 -1.271 -4.219 2 239 20 20 6q21 114 D 1.00 171 0.000 E B 33 1.64 -1.04 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.295 ? 76.19 +P01112 114 V S ? P01112 114 V S ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.364 -1.271 -3.635 2 239 20 20 6q21 114 D 1.00 171 0.000 E B -51 0.71 -1.04 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 5.616 ? 76.19 +P01112 114 V T ? P01112 114 V T ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.190 -1.271 -3.461 2 239 20 20 6q21 114 D 1.00 171 0.000 E B -24 0.66 -1.04 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 3.340 ? 76.19 +P01112 114 V W ? P01112 114 V W ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +4.099 -1.271 -5.370 2 239 20 20 6q21 114 D 1.00 171 0.000 E B 87 0.03 -1.04 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.137 ? 76.19 +P01112 114 V Y ? P01112 114 V Y ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.805 -1.271 -4.076 2 239 20 20 6q21 114 D 1.00 171 0.000 E B 53 0.23 -1.04 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 5.676 ? 76.19 +P01112 115 G A ? P01112 115 G A G C possibly damaging alignment ? deleterious 0.915 0.0601 0.813 0.0911 NO NO ? +0.737 -1.039 -1.776 2 239 20 20 6q21 115 D 1.00 171 0.000 E B 28 0.29 -0.75 ? ? ? ? ? ? ? 1 1 2 -54 PF00071.17 20.537 20.537 75.66 +P01112 115 G C ? P01112 115 G C ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.924 -1.039 -4.963 2 239 20 20 6q21 115 D 1.00 171 0.000 E B 48 0.75 -0.75 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.519 ? 75.66 +P01112 115 G D ? P01112 115 G D ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.580 -1.039 -3.619 2 239 20 20 6q21 115 D 1.00 171 0.000 E B 51 0.46 -0.75 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 3.181 ? 75.66 +P01112 115 G E ? P01112 115 G E G A probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.548 -1.039 -3.587 2 239 20 20 6q21 115 D 1.00 171 0.000 E B 78 0.75 -0.75 ? ? ? ? ? ? ? 0 1 0 -54 PF00071.17 5.376 ? 75.66 +P01112 115 G F ? P01112 115 G F ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.244 -1.039 -4.283 2 239 20 20 6q21 115 D 1.00 171 0.000 E B 130 0.87 -0.75 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.274 ? 75.66 +P01112 115 G H ? P01112 115 G H ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.025 -1.039 -3.064 2 239 20 20 6q21 115 D 1.00 171 0.000 E B 93 0.12 -0.75 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 26.037 26.037 75.66 +P01112 115 G I ? P01112 115 G I ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.039 -1.039 -4.078 2 239 20 20 6q21 115 D 1.00 171 0.000 E B 107 0.77 -0.75 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 3.046 ? 75.66 +P01112 115 G K ? P01112 115 G K ? ? probably damaging structure 1.1.1 deleterious 1 0.00026 0.00018 0.0109 NO NO ? +1.706 -1.039 -2.745 2 239 20 20 6q21 115 D 1.00 171 0.000 E B 108 2.05 -0.75 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 20.964 20.964 75.66 +P01112 115 G L ? P01112 115 G L ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.592 -1.039 -3.631 2 239 20 20 6q21 115 D 1.00 171 0.000 E B 107 0.84 -0.75 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 4.221 ? 75.66 +P01112 115 G M ? P01112 115 G M ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.794 -1.039 -4.833 2 239 20 20 6q21 115 D 1.00 171 0.000 E B 103 0.84 -0.75 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.281 ? 75.66 +P01112 115 G N ? P01112 115 G N ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.580 -1.039 -3.619 2 239 20 20 6q21 115 D 1.00 171 0.000 E B 54 0.32 -0.75 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 4.012 ? 75.66 +P01112 115 G P ? P01112 115 G P ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.855 -1.039 -3.894 2 239 20 20 6q21 115 D 1.00 171 0.000 E B 52 0.23 -0.75 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.061 ? 75.66 +P01112 115 G Q ? P01112 115 G Q ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.007 -1.039 -4.046 2 239 20 20 6q21 115 D 1.00 171 0.000 E B 84 0.35 -0.75 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 4.029 ? 75.66 +P01112 115 G R ? P01112 115 G R G A probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.782 -1.039 -3.821 2 239 20 20 6q21 115 D 1.00 171 0.000 E B 113 0.91 -0.75 ? ? ? ? ? ? ? 0 0 0 -53 PF00071.17 8.110 ? 75.66 +P01112 115 G S ? P01112 115 G S ? ? probably damaging alignment ? deleterious 0.999 0.00574 0.136 0.0192 NO NO ? +2.172 -1.039 -3.211 2 239 20 20 6q21 115 D 1.00 171 0.000 E B 29 0.02 -0.75 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 5.973 ? 75.66 +P01112 115 G T ? P01112 115 G T ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.550 -1.039 -3.589 2 239 20 20 6q21 115 D 1.00 171 0.000 E B 56 0.07 -0.75 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 3.552 ? 75.66 +P01112 115 G V ? P01112 115 G V G T probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.574 -1.039 -3.613 2 239 20 20 6q21 115 D 1.00 171 0.000 E B 80 0.73 -0.75 ? ? ? ? ? ? ? 1 1 0 -54 PF00071.17 4.841 ? 75.66 +P01112 115 G W ? P01112 115 G W G T probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +4.226 -1.039 -5.265 2 239 20 20 6q21 115 D 1.00 171 0.000 E B 167 0.76 -0.75 ? ? ? ? ? ? ? 1 0 0 -53 PF00071.17 0.426 ? 75.66 +P01112 115 G Y ? P01112 115 G Y ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.216 -1.039 -4.255 2 239 20 20 6q21 115 D 1.00 171 0.000 E B 133 0.5 -0.75 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 4.268 ? 75.66 +P01112 116 N A ? P01112 116 N A ? ? probably damaging alignment ? deleterious 0.998 0.0112 0.273 0.0274 NO NO ? +2.398 -0.905 -3.303 2 238 20 20 6q21 116 D 1.00 171 0.031 E B -26 0.61 -0.67 ? 1 3.184 ? ? ? ? ? ? ? ? PF00071.17 5.935 ? 75.66 +P01112 116 N C ? P01112 116 N C ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +4.255 -0.905 -5.160 2 238 20 20 6q21 116 D 1.00 171 0.031 E B -6 1.07 -0.67 ? 1 3.184 ? ? ? ? ? ? ? ? PF00071.17 0.785 ? 75.66 +P01112 116 N D ? P01112 116 N D A G probably damaging alignment ? deleterious 0.999 0.00574 0.136 0.0192 NO NO ? +2.256 -0.905 -3.161 2 238 20 20 6q21 116 D 1.00 171 0.031 E B -3 0.14 -0.67 ? 1 3.184 ? ? ? ? 0 0 0 -56 PF00071.17 3.092 ? 75.66 +P01112 116 N E ? P01112 116 N E ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.393 -0.905 -3.298 2 238 20 20 6q21 116 D 1.00 171 0.031 E B 24 0.43 -0.67 ? 1 3.184 ? ? ? ? ? ? ? ? PF00071.17 5.226 ? 75.66 +P01112 116 N F ? P01112 116 N F ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.460 -0.905 -4.365 2 238 20 20 6q21 116 D 1.00 171 0.031 E B 76 1.19 -0.67 ? 1 3.184 ? ? ? ? ? ? ? ? PF00071.17 1.222 ? 75.66 +P01112 116 N G ? P01112 116 N G ? ? probably damaging alignment ? deleterious 0.997 0.0167 0.409 0.0357 NO NO ? +1.431 -0.905 -2.336 2 238 20 20 6q21 116 D 1.00 171 0.031 E B -54 0.32 -0.67 ? 1 3.184 ? ? ? ? ? ? ? ? PF00071.17 38.576 38.576 75.66 +P01112 116 N H ? P01112 116 N H A C probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.255 -0.905 -4.160 2 238 20 20 6q21 116 D 1.00 171 0.031 E B 39 0.44 -0.67 ? 1 3.184 ? ? ? ? 1 0 0 -56 PF00071.17 1.502 ? 75.66 +P01112 116 N I ? P01112 116 N I A T probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.197 -0.905 -4.102 2 238 20 20 6q21 116 D 1.00 171 0.031 E B 53 1.09 -0.67 ? 1 3.184 ? ? ? ? 1 1 0 -57 PF00071.17 1.980 ? 75.66 +P01112 116 N K ? P01112 116 N K C G probably damaging structure 1.1.1 deleterious 1 0.00026 0.00018 0.0109 NO NO ? +1.660 -0.905 -2.565 2 238 20 20 6q21 116 D 1.00 171 0.031 E B 54 1.73 -0.67 ? 1 3.184 ? ? ? ? 1 2 0 -58 PF00071.17 20.377 20.377 75.66 +P01112 116 N L ? P01112 116 N L ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.747 -0.905 -3.652 2 238 20 20 6q21 116 D 1.00 171 0.031 E B 53 1.16 -0.67 ? 1 3.184 ? ? ? ? ? ? ? ? PF00071.17 3.115 ? 75.66 +P01112 116 N M ? P01112 116 N M ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.868 -0.905 -4.773 2 238 20 20 6q21 116 D 1.00 171 0.031 E B 49 1.16 -0.67 ? 1 3.184 ? ? ? ? ? ? ? ? PF00071.17 1.149 ? 75.66 +P01112 116 N P ? P01112 116 N P ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.025 -0.905 -3.930 2 238 20 20 6q21 116 D 1.00 171 0.031 E B -2 0.09 -0.67 ? 1 3.184 ? ? ? ? ? ? ? ? PF00071.17 1.995 ? 75.66 +P01112 116 N Q ? P01112 116 N Q ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.852 -0.905 -3.757 2 238 20 20 6q21 116 D 1.00 171 0.031 E B 30 0.0299999999999999 -0.67 ? 1 3.184 ? ? ? ? ? ? ? ? PF00071.17 3.916 ? 75.66 +P01112 116 N R ? P01112 116 N R ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.632 -0.905 -3.537 2 238 20 20 6q21 116 D 1.00 171 0.031 E B 59 0.59 -0.67 ? 1 3.184 ? ? ? ? ? ? ? ? PF00071.17 7.884 ? 75.66 +P01112 116 N S ? P01112 116 N S A G probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.141 -0.905 -3.046 2 238 20 20 6q21 116 D 1.00 171 0.031 E B -25 0.34 -0.67 ? 1 3.184 ? ? ? ? 0 1 0 -57 PF00071.17 3.922 ? 75.66 +P01112 116 N T ? P01112 116 N T A C probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.418 -0.905 -3.323 2 238 20 20 6q21 116 D 1.00 171 0.031 E B 2 0.39 -0.67 ? 1 3.184 ? ? ? ? 1 1 0 -57 PF00071.17 2.968 ? 75.66 +P01112 116 N V ? P01112 116 N V ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.899 -0.905 -3.804 2 238 20 20 6q21 116 D 1.00 171 0.031 E B 26 1.05 -0.67 ? 1 3.184 ? ? ? ? ? ? ? ? PF00071.17 2.448 ? 75.66 +P01112 116 N W ? P01112 116 N W ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +4.643 -0.905 -5.548 2 238 20 20 6q21 116 D 1.00 171 0.031 E B 113 1.08 -0.67 ? 1 3.184 ? ? ? ? ? ? ? ? PF00071.17 0.416 ? 75.66 +P01112 116 N Y ? P01112 116 N Y A T probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.349 -0.905 -4.254 2 238 20 20 6q21 116 D 1.00 171 0.031 E B 79 0.82 -0.67 ? 1 3.184 ? ? ? ? 1 0 0 -56 PF00071.17 1.263 ? 75.66 +P01112 117 K A ? P01112 117 K A ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.218 -0.970 -3.188 2 238 20 20 6q21 117 D 1.00 171 0.294 T l -80 2.34 -0.62 ? 1 3.145 ? ? ? ? ? ? ? ? PF00071.17 3.899 ? 83.07 +P01112 117 K C ? P01112 117 K C ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +4.119 -0.970 -5.089 2 238 20 20 6q21 117 D 1.00 171 0.294 T l -60 2.8 -0.62 ? 1 3.145 ? ? ? ? ? ? ? ? PF00071.17 1.340 ? 83.07 +P01112 117 K D ? P01112 117 K D ? ? probably damaging alignment ? deleterious 0.999 0.00574 0.136 0.0192 NO NO ? +2.616 -0.970 -3.586 2 238 20 20 6q21 117 D 1.00 171 0.294 T l -57 1.59 -0.62 ? 1 3.145 ? ? ? ? ? ? ? ? PF00071.17 6.128 ? 83.07 +P01112 117 K E ? P01112 117 K E A G probably damaging alignment ? deleterious 0.999 0.00574 0.136 0.0192 NO NO ? +2.237 -0.970 -3.207 2 238 20 20 6q21 117 D 1.00 171 0.294 T l -30 1.3 -0.62 ? 1 3.145 ? ? ? ? 0 0 2 -59 PF00071.17 3.640 ? 83.07 +P01112 117 K F ? P01112 117 K F ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.265 -0.970 -4.235 2 238 20 20 6q21 117 D 1.00 171 0.294 T l 22 2.92 -0.62 ? 1 3.145 ? ? ? ? ? ? ? ? PF00071.17 4.142 ? 83.07 +P01112 117 K G ? P01112 117 K G ? ? probably damaging alignment ? deleterious 0.999 0.00574 0.136 0.0192 NO NO ? +2.494 -0.970 -3.464 2 238 20 20 6q21 117 D 1.00 171 0.294 T l -108 2.05 -0.62 ? 1 3.145 ? ? ? ? ? ? ? ? PF00071.17 4.710 ? 83.07 +P01112 117 K H ? P01112 117 K H ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.591 -0.970 -4.561 2 238 20 20 6q21 117 D 1.00 171 0.294 T l -15 2.17 -0.62 ? 1 3.145 ? ? ? ? ? ? ? ? PF00071.17 2.356 ? 83.07 +P01112 117 K I ? P01112 117 K I ? ? possibly damaging alignment ? deleterious 0.793 0.0732 0.845 0.105 NO NO ? +1.890 -0.970 -2.860 2 238 20 20 6q21 117 D 1.00 171 0.294 T l -1 2.82 -0.62 ? 1 3.145 ? ? ? ? ? ? ? ? PF00071.17 22.556 22.556 83.07 +P01112 117 K L ? P01112 117 K L ? ? possibly damaging alignment ? deleterious 0.522 0.096 0.882 0.129 NO NO ? +1.617 -0.970 -2.587 2 238 20 20 6q21 117 D 1.00 171 0.294 T l -1 2.89 -0.62 ? 1 3.145 ? ? ? ? ? ? ? ? PF00071.17 28.412 28.412 83.07 +P01112 117 K M ? P01112 117 K M A T probably damaging alignment ? deleterious 0.999 0.00574 0.136 0.0192 NO NO ? +3.497 -0.970 -4.467 2 238 20 20 6q21 117 D 1.00 171 0.294 T l -5 2.89 -0.62 ? 1 3.145 ? ? ? ? 1 1 0 -60 PF00071.17 3.771 ? 83.07 +P01112 117 K N ? P01112 117 K N G C probably damaging alignment ? deleterious 0.966 0.0465 0.775 0.0751 NO NO ? +1.747 -0.970 -2.717 2 238 20 20 6q21 117 D 1.00 171 0.294 T l -54 1.73 -0.62 ? 1 3.145 ? ? ? ? 1 2 0 -61 PF00071.17 23.293 23.293 83.07 +P01112 117 K P ? P01112 117 K P ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.859 -0.970 -3.829 2 238 20 20 6q21 117 D 1.00 171 0.294 T l -56 1.82 -0.62 ? 1 3.145 ? ? ? ? ? ? ? ? PF00071.17 1.417 ? 83.07 +P01112 117 K Q ? P01112 117 K Q A C probably damaging alignment ? deleterious 0.998 0.0112 0.273 0.0274 NO NO ? +2.687 -0.970 -3.657 2 238 20 20 6q21 117 D 1.00 171 0.294 T l -24 1.7 -0.62 ? 1 3.145 ? ? ? ? 1 0 0 -59 PF00071.17 2.521 ? 83.07 +P01112 117 K R ? P01112 117 K R A G probably damaging alignment ? deleterious 0.998 0.0112 0.273 0.0274 NO NO ? +2.303 -0.970 -3.273 2 238 20 20 6q21 117 D 1.00 171 0.294 T l 5 1.14 -0.62 ? 1 3.145 ? ? ? ? 0 1 0 -60 PF00071.17 3.259 ? 83.07 +P01112 117 K S ? P01112 117 K S ? ? probably damaging alignment ? deleterious 0.999 0.00574 0.136 0.0192 NO NO ? +2.324 -0.970 -3.294 2 238 20 20 6q21 117 D 1.00 171 0.294 T l -79 2.07 -0.62 ? 1 3.145 ? ? ? ? ? ? ? ? PF00071.17 5.183 ? 83.07 +P01112 117 K T ? P01112 117 K T A C probably damaging alignment ? deleterious 0.999 0.00574 0.136 0.0192 NO NO ? +2.523 -0.970 -3.493 2 238 20 20 6q21 117 D 1.00 171 0.294 T l -52 2.12 -0.62 ? 1 3.145 ? ? ? ? 1 1 2 -60 PF00071.17 3.683 ? 83.07 +P01112 117 K V ? P01112 117 K V ? ? possibly damaging alignment ? deleterious 0.956 0.0501 0.785 0.0796 NO NO ? +2.437 -0.970 -3.407 2 238 20 20 6q21 117 D 1.00 171 0.294 T l -28 2.78 -0.62 ? 1 3.145 ? ? ? ? ? ? ? ? PF00071.17 14.644 ? 83.07 +P01112 117 K W ? P01112 117 K W ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +4.441 -0.970 -5.411 2 238 20 20 6q21 117 D 1.00 171 0.294 T l 59 2.81 -0.62 ? 1 3.145 ? ? ? ? ? ? ? ? PF00071.17 0.560 ? 83.07 +P01112 117 K Y ? P01112 117 K Y ? ? probably damaging alignment ? deleterious 0.999 0.00574 0.136 0.0192 NO NO ? +3.244 -0.970 -4.214 2 238 20 20 6q21 117 D 1.00 171 0.294 T l 25 2.55 -0.62 ? 1 3.145 ? ? ? ? ? ? ? ? PF00071.17 1.690 ? 83.07 +P01112 118 C A ? P01112 118 C A ? ? benign sequence annotation 2.2 neutral 0.007 0.246 0.965 0.257 MOD_RES NO ? +0.665 -1.798 -2.463 2 238 20 20 6q21 118 D 1.00 171 0.457 T A -20 0.46 -0.70 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 23.142 23.142 84.66 +P01112 118 C D ? P01112 118 C D ? ? possibly damaging sequence annotation 2.2 deleterious 0.777 0.0751 0.848 0.107 MOD_RES NO ? +2.183 -1.798 -3.981 2 238 20 20 6q21 118 D 1.00 171 0.457 T A 3 1.21 -0.70 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 3.966 ? 84.66 +P01112 118 C E ? P01112 118 C E ? ? possibly damaging sequence annotation 2.2 deleterious 0.84 0.0683 0.836 0.0997 MOD_RES NO ? +2.069 -1.798 -3.867 2 238 20 20 6q21 118 D 1.00 171 0.457 T A 30 1.5 -0.70 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 6.777 ? 84.66 +P01112 118 C F ? P01112 118 C F G T possibly damaging sequence annotation 2.2 deleterious 0.914 0.0603 0.813 0.0913 MOD_RES NO ? +2.219 -1.798 -4.017 2 238 20 20 6q21 118 D 1.00 171 0.457 T A 82 0.12 -0.70 ? ? ? ? ? ? ? 1 1 0 -63 PF00071.17 11.117 ? 84.66 +P01112 118 C G ? P01112 118 C G T G possibly damaging sequence annotation 2.2 deleterious 0.681 0.0843 0.862 0.117 MOD_RES NO ? +1.872 -1.798 -3.670 2 238 20 20 6q21 118 D 1.00 171 0.457 T A -48 0.75 -0.70 ? ? ? ? ? ? ? 1 0 0 -62 PF00071.17 6.261 ? 84.66 +P01112 118 C H ? P01112 118 C H ? ? probably damaging sequence annotation 2.2 deleterious 0.975 0.0436 0.762 0.072 MOD_RES NO ? +3.064 -1.798 -4.862 2 238 20 20 6q21 118 D 1.00 171 0.457 T A 45 0.63 -0.70 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 3.990 ? 84.66 +P01112 118 C I ? P01112 118 C I ? ? benign sequence annotation 2.2 neutral 0.024 0.191 0.95 0.214 MOD_RES NO ? +0.693 -1.798 -2.491 2 238 20 20 6q21 118 D 1.00 171 0.457 T A 59 0.02 -0.70 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 19.826 19.826 84.66 +P01112 118 C K ? P01112 118 C K ? ? possibly damaging sequence annotation 2.2 deleterious 0.933 0.0573 0.804 0.0882 MOD_RES NO ? +2.054 -1.798 -3.852 2 238 20 20 6q21 118 D 1.00 171 0.457 T A 60 2.8 -0.70 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 5.931 ? 84.66 +P01112 118 C L ? P01112 118 C L ? ? benign sequence annotation 2.2 neutral 0.055 0.163 0.94 0.191 MOD_RES NO ? +0.863 -1.798 -2.661 2 238 20 20 6q21 118 D 1.00 171 0.457 T A 59 0.09 -0.70 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 28.412 28.412 84.66 +P01112 118 C M ? P01112 118 C M ? ? probably damaging sequence annotation 2.2 deleterious 0.966 0.0465 0.775 0.0751 MOD_RES NO ? +2.676 -1.798 -4.474 2 238 20 20 6q21 118 D 1.00 171 0.457 T A 55 0.09 -0.70 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 3.771 ? 84.66 +P01112 118 C N ? P01112 118 C N ? ? possibly damaging sequence annotation 2.2 deleterious 0.882 0.0644 0.824 0.0959 MOD_RES NO ? +2.315 -1.798 -4.113 2 238 20 20 6q21 118 D 1.00 171 0.457 T A 6 1.07 -0.70 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 4.451 ? 84.66 +P01112 118 C P ? P01112 118 C P ? ? possibly damaging sequence annotation 2.2 deleterious 0.876 0.0651 0.826 0.0966 MOD_RES NO ? +2.332 -1.798 -4.130 2 238 20 20 6q21 118 D 1.00 171 0.457 T A 4 0.98 -0.70 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.357 ? 84.66 +P01112 118 C Q ? P01112 118 C Q ? ? benign sequence annotation 2.2 neutral 0.34 0.11 0.9 0.142 MOD_RES NO ? +1.431 -1.798 -3.229 2 238 20 20 6q21 118 D 1.00 171 0.457 T A 36 1.1 -0.70 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 14.036 14.036 84.66 +P01112 118 C R ? P01112 118 C R T C possibly damaging sequence annotation 2.2 deleterious 0.914 0.0603 0.813 0.0913 MOD_RES NO ? +2.361 -1.798 -4.159 2 238 20 20 6q21 118 D 1.00 171 0.457 T A 65 1.66 -0.70 ? ? ? ? ? ? ? 0 0 2 -62 PF00071.17 4.761 ? 84.66 +P01112 118 C S ? P01112 118 C S G C benign sequence annotation 2.2 neutral 0.107 0.143 0.928 0.173 MOD_RES NO ? +1.109 -1.798 -2.907 2 238 20 20 6q21 118 D 1.00 171 0.457 T A -19 0.73 -0.70 ? ? ? ? ? ? ? 1 1 0 -63 PF00071.17 17.803 17.803 84.66 +P01112 118 C T ? P01112 118 C T ? ? benign sequence annotation 2.2 neutral 0.162 0.132 0.92 0.162 MOD_RES NO ? +0.856 -1.798 -2.654 2 238 20 20 6q21 118 D 1.00 171 0.457 T A 8 0.68 -0.70 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 12.231 12.231 84.66 +P01112 118 C V ? P01112 118 C V ? ? benign sequence annotation 2.2 neutral 0.004 0.408 0.975 0.328 MOD_RES NO ? +0.180 -1.798 -1.978 2 238 20 20 6q21 118 D 1.00 171 0.457 T A 32 0.02 -0.70 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 21.225 21.225 84.66 +P01112 118 C W ? P01112 118 C W T G probably damaging sequence annotation 2.2 deleterious 0.994 0.0289 0.689 0.0537 MOD_RES NO ? +3.479 -1.798 -5.277 2 238 20 20 6q21 118 D 1.00 171 0.457 T A 119 0.01 -0.70 ? ? ? ? ? ? ? 1 2 0 -64 PF00071.17 2.327 ? 84.66 +P01112 118 C Y ? P01112 118 C Y G A benign sequence annotation 2.2 neutral 0.091 0.149 0.931 0.178 MOD_RES NO ? +1.083 -1.798 -2.881 2 238 20 20 6q21 118 D 1.00 171 0.457 T A 85 0.25 -0.70 ? ? ? ? ? ? ? 0 1 0 -63 PF00071.17 26.870 26.870 84.66 +P01112 119 D A ? P01112 119 D A A C possibly damaging structure 2.2.3 deleterious 0.863 0.0664 0.83 0.0978 NO NO ? +1.676 -0.858 -2.534 2 238 20 20 6q21 119 D 1.00 171 0.378 T A -23 0.75 -0.48 ? 1 2.457 ? ? ? ? 1 1 0 -66 PF00071.17 23.602 23.602 81.48 +P01112 119 D C ? P01112 119 D C ? ? probably damaging structure 2.2.3 deleterious 0.999 0.00574 0.136 0.0192 NO NO ? +4.171 -0.858 -5.029 2 238 20 20 6q21 119 D 1.00 171 0.378 T A -3 1.21 -0.48 ? 1 2.457 ? ? ? ? ? ? ? ? PF00071.17 1.746 ? 81.48 +P01112 119 D E ? P01112 119 D E C G probably damaging structure 2.2.3 deleterious 0.984 0.0381 0.743 0.065 NO NO ? +2.085 -0.858 -2.943 2 238 20 20 6q21 119 D 1.00 171 0.378 T A 27 0.29 -0.48 ? 1 2.457 ? ? ? ? 1 2 0 -67 PF00071.17 3.280 ? 81.48 +P01112 119 D F ? P01112 119 D F ? ? probably damaging structure 2.2.3 deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.434 -0.858 -4.292 2 238 20 20 6q21 119 D 1.00 171 0.378 T A 79 1.33 -0.48 ? 1 2.457 ? ? ? ? ? ? ? ? PF00071.17 2.673 ? 81.48 +P01112 119 D G ? P01112 119 D G A G probably damaging structure 2.2.3 deleterious 0.995 0.0277 0.681 0.0521 NO NO ? +2.358 -0.858 -3.216 2 238 20 20 6q21 119 D 1.00 171 0.378 T A -51 0.46 -0.48 ? 1 2.457 ? ? ? ? 0 1 0 -66 PF00071.17 6.385 ? 81.48 +P01112 119 D H ? P01112 119 D H G C probably damaging structure 2.2.3 deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.723 -0.858 -4.581 2 238 20 20 6q21 119 D 1.00 171 0.378 T A 42 0.58 -0.48 ? 1 2.457 ? ? ? ? 1 0 0 -65 PF00071.17 1.216 ? 81.48 +P01112 119 D I ? P01112 119 D I ? ? probably damaging structure 2.2.3 deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.952 -0.858 -3.810 2 238 20 20 6q21 119 D 1.00 171 0.378 T A 56 1.23 -0.48 ? 1 2.457 ? ? ? ? ? ? ? ? PF00071.17 12.423 ? 81.48 +P01112 119 D K ? P01112 119 D K ? ? probably damaging structure 2.2.3 deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.691 -0.858 -3.549 2 238 20 20 6q21 119 D 1.00 171 0.378 T A 57 1.59 -0.48 ? 1 2.457 ? ? ? ? ? ? ? ? PF00071.17 3.674 ? 81.48 +P01112 119 D L ? P01112 119 D L ? ? probably damaging structure 2.2.3 deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.777 -0.858 -3.635 2 238 20 20 6q21 119 D 1.00 171 0.378 T A 56 1.3 -0.48 ? 1 2.457 ? ? ? ? ? ? ? ? PF00071.17 9.835 ? 81.48 +P01112 119 D M ? P01112 119 D M ? ? probably damaging structure 2.2.3 deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.974 -0.858 -4.832 2 238 20 20 6q21 119 D 1.00 171 0.378 T A 52 1.3 -0.48 ? 1 2.457 ? ? ? ? ? ? ? ? PF00071.17 2.399 ? 81.48 +P01112 119 D N ? P01112 119 D N G A probably damaging structure 2.2.3 deleterious 0.998 0.0112 0.273 0.0274 NO NO ? +2.543 -0.858 -3.401 2 238 20 20 6q21 119 D 1.00 171 0.378 T A 3 0.14 -0.48 ? 1 2.457 ? ? ? ? 0 0 0 -65 PF00071.17 2.140 ? 81.48 +P01112 119 D P ? P01112 119 D P ? ? probably damaging structure 2.2.3 deleterious 0.997 0.0167 0.409 0.0357 NO NO ? +2.888 -0.858 -3.746 2 238 20 20 6q21 119 D 1.00 171 0.378 T A 1 0.23 -0.48 ? 1 2.457 ? ? ? ? ? ? ? ? PF00071.17 2.368 ? 81.48 +P01112 119 D Q ? P01112 119 D Q ? ? probably damaging structure 2.2.3 deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.942 -0.858 -3.800 2 238 20 20 6q21 119 D 1.00 171 0.378 T A 33 0.11 -0.48 ? 1 2.457 ? ? ? ? ? ? ? ? PF00071.17 2.113 ? 81.48 +P01112 119 D R ? P01112 119 D R ? ? probably damaging structure 2.2.3 deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.143 -0.858 -4.001 2 238 20 20 6q21 119 D 1.00 171 0.378 T A 62 0.45 -0.48 ? 1 2.457 ? ? ? ? ? ? ? ? PF00071.17 2.577 ? 81.48 +P01112 119 D S ? P01112 119 D S ? ? probably damaging structure 2.2.3 deleterious 0.997 0.0167 0.409 0.0357 NO NO ? +2.386 -0.858 -3.244 2 238 20 20 6q21 119 D 1.00 171 0.378 T A -22 0.48 -0.48 ? 1 2.457 ? ? ? ? ? ? ? ? PF00071.17 6.865 ? 81.48 +P01112 119 D T ? P01112 119 D T ? ? probably damaging structure 2.2.3 deleterious 0.997 0.0167 0.409 0.0357 NO NO ? +2.591 -0.858 -3.449 2 238 20 20 6q21 119 D 1.00 171 0.378 T A 5 0.53 -0.48 ? 1 2.457 ? ? ? ? ? ? ? ? PF00071.17 4.082 ? 81.48 +P01112 119 D V ? P01112 119 D V A T possibly damaging structure 2.2.3 deleterious 0.933 0.0573 0.804 0.0882 NO NO ? +1.864 -0.858 -2.722 2 238 20 20 6q21 119 D 1.00 171 0.378 T A 29 1.19 -0.48 ? 1 2.457 ? ? ? ? 1 1 0 -66 PF00071.17 20.370 20.370 81.48 +P01112 119 D W ? P01112 119 D W ? ? probably damaging structure 2.2.3 deleterious 1 0.00026 0.00018 0.0109 NO NO ? +4.717 -0.858 -5.575 2 238 20 20 6q21 119 D 1.00 171 0.378 T A 116 1.22 -0.48 ? 1 2.457 ? ? ? ? ? ? ? ? PF00071.17 0.442 ? 81.48 +P01112 119 D Y ? P01112 119 D Y G T probably damaging structure 2.2.3 deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.530 -0.858 -4.388 2 238 20 20 6q21 119 D 1.00 171 0.378 T A 82 0.96 -0.48 ? 1 2.457 ? ? ? ? 1 0 0 -65 PF00071.17 1.607 ? 81.48 +P01112 120 L A ? P01112 120 L A ? ? benign alignment ? neutral 0.174 0.13 0.919 0.161 NO NO ? +1.264 -1.339 -2.603 2 238 20 20 6q21 120 D 1.00 171 0.453 . B -79 0.55 -0.29 ? 1 3.160 ? ? ? ? ? ? ? ? PF00071.17 21.916 21.916 84.13 +P01112 120 L C ? P01112 120 L C ? ? probably damaging alignment ? deleterious 0.997 0.0167 0.409 0.0357 NO NO ? +3.516 -1.339 -4.855 2 238 20 20 6q21 120 D 1.00 171 0.453 . B -59 0.09 -0.29 ? 1 3.160 ? ? ? ? ? ? ? ? PF00071.17 1.621 ? 84.13 +P01112 120 L D ? P01112 120 L D ? ? probably damaging alignment ? deleterious 0.978 0.0417 0.756 0.0695 NO NO ? +2.669 -1.339 -4.008 2 238 20 20 6q21 120 D 1.00 171 0.453 . B -56 1.3 -0.29 ? 1 3.160 ? ? ? ? ? ? ? ? PF00071.17 4.121 ? 84.13 +P01112 120 L E ? P01112 120 L E ? ? probably damaging alignment ? deleterious 0.97 0.0446 0.769 0.0728 NO NO ? +2.478 -1.339 -3.817 2 238 20 20 6q21 120 D 1.00 171 0.453 . B -29 1.59 -0.29 ? 1 3.160 ? ? ? ? ? ? ? ? PF00071.17 4.342 ? 84.13 +P01112 120 L F ? P01112 120 L F ? ? benign alignment ? neutral 0.169 0.131 0.919 0.162 NO NO ? +1.650 -1.339 -2.989 2 238 20 20 6q21 120 D 1.00 171 0.453 . B 23 0.03 -0.29 ? 1 3.160 ? ? ? ? ? ? ? ? PF00071.17 25.289 25.289 84.13 +P01112 120 L G ? P01112 120 L G ? ? benign alignment ? neutral 0.174 0.13 0.919 0.161 NO NO ? +1.193 -1.339 -2.532 2 238 20 20 6q21 120 D 1.00 171 0.453 . B -107 0.84 -0.29 ? 1 3.160 ? ? ? ? ? ? ? ? PF00071.17 25.898 25.898 84.13 +P01112 120 L H ? P01112 120 L H ? ? probably damaging alignment ? deleterious 0.993 0.0301 0.696 0.0553 NO NO ? +3.572 -1.339 -4.911 2 238 20 20 6q21 120 D 1.00 171 0.453 . B -14 0.72 -0.29 ? 1 3.160 ? ? ? ? ? ? ? ? PF00071.17 1.625 ? 84.13 +P01112 120 L I ? P01112 120 L I ? ? benign alignment ? neutral 0.395 0.105 0.896 0.137 NO NO ? +1.919 -1.339 -3.258 2 238 20 20 6q21 120 D 1.00 171 0.453 . B 0 0.07 -0.29 ? 1 3.160 ? ? ? ? ? ? ? ? PF00071.17 7.992 ? 84.13 +P01112 120 L K ? P01112 120 L K ? ? benign alignment ? neutral 0.06 0.161 0.938 0.189 NO NO ? +1.568 -1.339 -2.907 2 238 20 20 6q21 120 D 1.00 171 0.453 . B 1 2.89 -0.29 ? 1 3.160 ? ? ? ? ? ? ? ? PF00071.17 13.780 13.780 84.13 +P01112 120 L M ? P01112 120 L M C A benign alignment ? neutral 0.364 0.108 0.898 0.14 NO NO ? +1.526 -1.339 -2.865 2 238 20 20 6q21 120 D 1.00 171 0.453 . B -4 0 -0.29 ? 1 3.160 ? ? ? ? 1 0 0 -68 PF00071.17 7.970 7.970 84.13 +P01112 120 L N ? P01112 120 L N ? ? probably damaging alignment ? deleterious 0.957 0.0496 0.784 0.079 NO NO ? +2.699 -1.339 -4.038 2 238 20 20 6q21 120 D 1.00 171 0.453 . B -53 1.16 -0.29 ? 1 3.160 ? ? ? ? ? ? ? ? PF00071.17 4.626 ? 84.13 +P01112 120 L P ? P01112 120 L P T C probably damaging alignment ? deleterious 0.996 0.0222 0.545 0.0439 NO NO ? +2.769 -1.339 -4.108 2 238 20 20 6q21 120 D 1.00 171 0.453 . B -55 1.07 -0.29 ? 1 3.160 ? ? ? ? 0 1 2 -69 PF00071.17 2.449 ? 84.13 +P01112 120 L Q ? P01112 120 L Q T A probably damaging alignment ? deleterious 0.981 0.0399 0.75 0.0672 NO NO ? +2.806 -1.339 -4.145 2 238 20 20 6q21 120 D 1.00 171 0.453 . B -23 1.19 -0.29 ? 1 3.160 ? ? ? ? 1 1 0 -69 PF00071.17 2.783 ? 84.13 +P01112 120 L R ? P01112 120 L R T G possibly damaging alignment ? deleterious 0.87 0.0657 0.828 0.0971 NO NO ? +2.654 -1.339 -3.993 2 238 20 20 6q21 120 D 1.00 171 0.453 . B 6 1.75 -0.29 ? 1 3.160 ? ? ? ? 1 1 2 -69 PF00071.17 5.331 ? 84.13 +P01112 120 L S ? P01112 120 L S ? ? possibly damaging alignment ? deleterious 0.686 0.0835 0.861 0.116 NO NO ? +1.511 -1.339 -2.850 2 238 20 20 6q21 120 D 1.00 171 0.453 . B -78 0.82 -0.29 ? 1 3.160 ? ? ? ? ? ? ? ? PF00071.17 18.501 18.501 84.13 +P01112 120 L T ? P01112 120 L T ? ? possibly damaging alignment ? deleterious 0.87 0.0657 0.828 0.0971 NO NO ? +2.195 -1.339 -3.534 2 238 20 20 6q21 120 D 1.00 171 0.453 . B -51 0.77 -0.29 ? 1 3.160 ? ? ? ? ? ? ? ? PF00071.17 6.910 ? 84.13 +P01112 120 L V ? P01112 120 L V C G benign alignment ? neutral 0.032 0.18 0.946 0.205 NO NO ? +0.954 -1.339 -2.293 2 238 20 20 6q21 120 D 1.00 171 0.453 . B -27 0.11 -0.29 ? 1 3.160 ? ? ? ? 1 0 2 -68 PF00071.17 13.105 13.105 84.13 +P01112 120 L W ? P01112 120 L W ? ? probably damaging alignment ? deleterious 0.999 0.00574 0.136 0.0192 NO NO ? +3.900 -1.339 -5.239 2 238 20 20 6q21 120 D 1.00 171 0.453 . B 60 0.08 -0.29 ? 1 3.160 ? ? ? ? ? ? ? ? PF00071.17 1.175 ? 84.13 +P01112 120 L Y ? P01112 120 L Y ? ? possibly damaging alignment ? deleterious 0.509 0.0964 0.883 0.129 NO NO ? +2.742 -1.339 -4.081 2 238 20 20 6q21 120 D 1.00 171 0.453 . B 26 0.34 -0.29 ? 1 3.160 ? ? ? ? ? ? ? ? PF00071.17 5.865 ? 84.13 +P01112 121 A C ? P01112 121 A C ? ? possibly damaging alignment ? neutral 0.491 0.0977 0.885 0.13 NO NO ? +2.816 -2.284 -5.100 2 235 20 20 6q21 121 D 1.00 171 0.932 S B 20 0.46 0.28 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.476 ? 94.18 +P01112 121 A D ? P01112 121 A D C A benign alignment ? neutral 0 1 1 0.575 NO NO ? +0.430 -2.284 -2.714 2 235 20 20 6q21 121 D 1.00 171 0.932 S B 23 0.75 0.28 ? ? ? ? ? ? ? 1 1 0 -72 PF00071.17 26.448 26.448 94.18 +P01112 121 A E ? P01112 121 A E ? ? benign alignment ? neutral 0 1 1 0.575 NO NO ? +0.412 -2.284 -2.696 2 235 20 20 6q21 121 D 1.00 171 0.932 S B 50 1.04 0.28 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 19.175 19.175 94.18 +P01112 121 A F ? P01112 121 A F ? ? benign alignment ? neutral 0.239 0.12 0.912 0.151 NO NO ? +2.166 -2.284 -4.450 2 235 20 20 6q21 121 D 1.00 171 0.932 S B 102 0.58 0.28 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.963 ? 94.18 +P01112 121 A G ? P01112 121 A G C G benign alignment ? neutral 0 1 1 0.575 NO NO ? +0.518 -2.284 -2.802 2 235 20 20 6q21 121 D 1.00 171 0.932 S B -28 0.29 0.28 ? ? ? ? ? ? ? 1 1 0 -72 PF00071.17 40.465 40.465 94.18 +P01112 121 A H ? P01112 121 A H ? ? benign alignment ? neutral 0.001 0.852 0.994 0.514 NO NO ? +1.119 -2.284 -3.403 2 235 20 20 6q21 121 D 1.00 171 0.932 S B 65 0.17 0.28 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 22.478 22.478 94.18 +P01112 121 A I ? P01112 121 A I ? ? benign alignment ? neutral 0.042 0.172 0.943 0.198 NO NO ? +1.809 -2.284 -4.093 2 235 20 20 6q21 121 D 1.00 171 0.932 S B 79 0.48 0.28 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 4.203 ? 94.18 +P01112 121 A K ? P01112 121 A K ? ? benign alignment ? neutral 0.009 0.233 0.961 0.247 NO NO ? +1.261 -2.284 -3.545 2 235 20 20 6q21 121 D 1.00 171 0.932 S B 80 2.34 0.28 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 7.413 ? 94.18 +P01112 121 A L ? P01112 121 A L ? ? benign alignment ? neutral 0.009 0.233 0.961 0.247 NO NO ? +1.369 -2.284 -3.653 2 235 20 20 6q21 121 D 1.00 171 0.932 S B 79 0.55 0.28 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 5.183 ? 94.18 +P01112 121 A M ? P01112 121 A M ? ? benign alignment ? neutral 0.239 0.12 0.912 0.151 NO NO ? +2.542 -2.284 -4.826 2 235 20 20 6q21 121 D 1.00 171 0.932 S B 75 0.55 0.28 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.771 ? 94.18 +P01112 121 A N ? P01112 121 A N ? ? benign alignment ? neutral 0 1 1 0.575 NO NO ? +0.512 -2.284 -2.796 2 235 20 20 6q21 121 D 1.00 171 0.932 S B 26 0.61 0.28 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 20.612 20.612 94.18 +P01112 121 A P ? P01112 121 A P G C benign alignment ? neutral 0 1 1 0.575 NO NO ? -0.241 -2.284 -2.043 2 235 20 20 6q21 121 D 1.00 171 0.932 S B 24 0.52 0.28 ? ? ? ? ? ? ? 1 0 0 -71 PF00071.17 46.594 46.594 94.18 +P01112 121 A Q ? P01112 121 A Q ? ? benign alignment ? neutral 0.001 0.852 0.994 0.514 NO NO ? +0.636 -2.284 -2.920 2 235 20 20 6q21 121 D 1.00 171 0.932 S B 56 0.64 0.28 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 17.545 17.545 94.18 +P01112 121 A R ? P01112 121 A R ? ? benign alignment ? neutral 0.001 0.852 0.994 0.514 NO NO ? +0.845 -2.284 -3.129 2 235 20 20 6q21 121 D 1.00 171 0.932 S B 85 1.2 0.28 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 16.929 16.929 94.18 +P01112 121 A S ? P01112 121 A S G T benign alignment ? neutral 0 1 1 0.575 NO NO ? -0.056 -2.284 -2.228 2 235 20 20 6q21 121 D 1.00 171 0.932 S B 1 0.27 0.28 ? ? ? ? ? ? ? 1 0 0 -71 PF00071.17 17.803 17.803 94.18 +P01112 121 A T ? P01112 121 A T G A benign alignment ? neutral 0 1 1 0.575 NO NO ? -0.036 -2.284 -2.248 2 235 20 20 6q21 121 D 1.00 171 0.932 S B 28 0.22 0.28 ? ? ? ? ? ? ? 0 0 0 -71 PF00071.17 19.517 19.517 94.18 +P01112 121 A V ? P01112 121 A V C T benign alignment ? neutral 0.006 0.253 0.967 0.262 NO NO ? +1.400 -2.284 -3.684 2 235 20 20 6q21 121 D 1.00 171 0.932 S B 52 0.44 0.28 ? ? ? ? ? ? ? 0 1 0 -72 PF00071.17 5.677 ? 94.18 +P01112 121 A W ? P01112 121 A W ? ? possibly damaging alignment ? deleterious 0.783 0.0745 0.848 0.106 NO NO ? +3.270 -2.284 -5.554 2 235 20 20 6q21 121 D 1.00 171 0.932 S B 139 0.47 0.28 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 0.544 ? 94.18 +P01112 121 A Y ? P01112 121 A Y ? ? benign alignment ? neutral 0.134 0.138 0.924 0.168 NO NO ? +2.098 -2.284 -4.382 2 235 20 20 6q21 121 D 1.00 171 0.932 S B 105 0.21 0.28 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 3.685 ? 94.18 +P01112 122 A C ? P01112 122 A C ? ? benign alignment ? neutral 0.002 0.704 0.987 0.452 NO NO ? +1.081 -2.575 -3.656 2 236 20 20 6q21 122 D 1.00 171 0.680 . g 20 0.46 -0.50 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 35.800 35.800 86.24 +P01112 122 A D ? P01112 122 A D ? ? benign alignment ? neutral 0 1 1 0.575 NO NO ? -0.158 -2.575 -2.417 2 236 20 20 6q21 122 D 1.00 171 0.680 . g 23 0.75 -0.50 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 28.127 28.127 86.24 +P01112 122 A E ? P01112 122 A E C A benign alignment ? neutral 0 1 1 0.575 NO NO ? +0.101 -2.575 -2.676 2 236 20 20 6q21 122 D 1.00 171 0.680 . g 50 1.04 -0.50 ? ? ? ? ? ? ? 1 1 0 -75 PF00071.17 19.804 19.804 86.24 +P01112 122 A F ? P01112 122 A F ? ? benign alignment ? neutral 0.002 0.704 0.987 0.452 NO NO ? +0.563 -2.575 -3.138 2 236 20 20 6q21 122 D 1.00 171 0.680 . g 102 0.58 -0.50 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 31.611 31.611 86.24 +P01112 122 A G ? P01112 122 A G C G benign alignment ? neutral 0 1 1 0.575 NO NO ? +0.408 -2.575 -2.983 2 236 20 20 6q21 122 D 1.00 171 0.680 . g -28 0.29 -0.50 ? ? ? ? ? ? ? 1 1 0 -75 PF00071.17 38.576 38.576 86.24 +P01112 122 A H ? P01112 122 A H ? ? benign alignment ? neutral 0.004 0.408 0.975 0.328 NO NO ? +0.975 -2.575 -3.550 2 236 20 20 6q21 122 D 1.00 171 0.680 . g 65 0.17 -0.50 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 22.853 22.853 86.24 +P01112 122 A I ? P01112 122 A I ? ? benign alignment ? neutral 0.002 0.704 0.987 0.452 NO NO ? +0.690 -2.575 -3.265 2 236 20 20 6q21 122 D 1.00 171 0.680 . g 79 0.48 -0.50 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 20.544 20.544 86.24 +P01112 122 A K ? P01112 122 A K ? ? benign alignment ? neutral 0.003 0.556 0.981 0.39 NO NO ? +0.312 -2.575 -2.887 2 236 20 20 6q21 122 D 1.00 171 0.680 . g 80 2.34 -0.50 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 17.299 17.299 86.24 +P01112 122 A L ? P01112 122 A L ? ? benign alignment ? neutral 0.002 0.704 0.987 0.452 NO NO ? +0.453 -2.575 -3.028 2 236 20 20 6q21 122 D 1.00 171 0.680 . g 79 0.55 -0.50 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 21.458 21.458 86.24 +P01112 122 A M ? P01112 122 A M ? ? possibly damaging alignment ? deleterious 0.66 0.0865 0.864 0.119 NO NO ? +2.192 -2.575 -4.767 2 236 20 20 6q21 122 D 1.00 171 0.680 . g 75 0.55 -0.50 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.848 ? 86.24 +P01112 122 A N ? P01112 122 A N ? ? benign alignment ? neutral 0 1 1 0.575 NO NO ? +0.202 -2.575 -2.777 2 236 20 20 6q21 122 D 1.00 171 0.680 . g 26 0.61 -0.50 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 23.964 23.964 86.24 +P01112 122 A P ? P01112 122 A P G C benign alignment ? neutral 0.185 0.128 0.917 0.159 NO NO ? +1.516 -2.575 -4.091 2 236 20 20 6q21 122 D 1.00 171 0.680 . g 24 0.52 -0.50 ? ? ? ? ? ? ? 1 0 0 -74 PF00071.17 2.496 ? 86.24 +P01112 122 A Q ? P01112 122 A Q ? ? benign alignment ? neutral 0.003 0.556 0.981 0.39 NO NO ? +0.152 -2.575 -2.727 2 236 20 20 6q21 122 D 1.00 171 0.680 . g 56 0.64 -0.50 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 17.092 17.092 86.24 +P01112 122 A R ? P01112 122 A R ? ? benign alignment ? neutral 0.002 0.704 0.987 0.452 NO NO ? +0.680 -2.575 -3.255 2 236 20 20 6q21 122 D 1.00 171 0.680 . g 85 1.2 -0.50 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 25.120 25.120 86.24 +P01112 122 A S ? P01112 122 A S G T benign alignment ? neutral 0 1 1 0.575 NO NO ? -0.039 -2.575 -2.536 2 236 20 20 6q21 122 D 1.00 171 0.680 . g 1 0.27 -0.50 ? ? ? ? ? ? ? 1 0 0 -74 PF00071.17 18.850 18.850 86.24 +P01112 122 A T ? P01112 122 A T G A benign alignment ? neutral 0 1 1 0.575 NO NO ? -0.152 -2.575 -2.423 2 236 20 20 6q21 122 D 1.00 171 0.680 . g 28 0.22 -0.50 ? ? ? ? ? ? ? 0 0 0 -74 PF00071.17 21.208 21.208 86.24 +P01112 122 A V ? P01112 122 A V C T benign alignment ? neutral 0 1 1 0.575 NO NO ? +0.512 -2.575 -3.087 2 236 20 20 6q21 122 D 1.00 171 0.680 . g 52 0.44 -0.50 ? ? ? ? ? ? ? 0 1 0 -75 PF00071.17 20.513 20.513 86.24 +P01112 122 A W ? P01112 122 A W ? ? probably damaging alignment ? deleterious 0.978 0.0417 0.756 0.0695 NO NO ? +2.873 -2.575 -5.448 2 236 20 20 6q21 122 D 1.00 171 0.680 . g 139 0.47 -0.50 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.484 ? 86.24 +P01112 122 A Y ? P01112 122 A Y ? ? benign alignment ? neutral 0.017 0.205 0.954 0.225 NO NO ? +0.802 -2.575 -3.377 2 236 20 20 6q21 122 D 1.00 171 0.680 . g 105 0.21 -0.50 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 17.129 17.129 86.24 +P01112 123 R A ? P01112 123 R A ? ? probably damaging alignment ? deleterious 0.998 0.0112 0.273 0.0274 NO NO ? +2.056 -1.202 -3.258 2 238 20 20 6q21 123 D 1.00 171 0.261 . B -85 1.2 -0.20 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 3.465 ? 82.01 +P01112 123 R C ? P01112 123 R C C T probably damaging alignment ? deleterious 0.986 0.0368 0.736 0.0634 NO NO ? +1.949 -1.202 -3.151 2 238 20 20 6q21 123 D 1.00 171 0.261 . B -65 1.66 -0.20 ? ? ? ? ? ? ? 0 0 1 -77 PF00071.17 24.037 24.037 82.01 +P01112 123 R D ? P01112 123 R D ? ? possibly damaging alignment ? deleterious 0.823 0.0698 0.839 0.101 NO NO ? +1.595 -1.202 -2.797 2 238 20 20 6q21 123 D 1.00 171 0.261 . B -62 0.45 -0.20 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 30.016 30.016 82.01 +P01112 123 R E ? P01112 123 R E ? ? probably damaging alignment ? deleterious 0.984 0.0381 0.743 0.065 NO NO ? +2.205 -1.202 -3.407 2 238 20 20 6q21 123 D 1.00 171 0.261 . B -35 0.16 -0.20 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 6.936 ? 82.01 +P01112 123 R F ? P01112 123 R F ? ? probably damaging alignment ? deleterious 0.997 0.0167 0.409 0.0357 NO NO ? +2.944 -1.202 -4.146 2 238 20 20 6q21 123 D 1.00 171 0.261 . B 17 1.78 -0.20 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 5.069 ? 82.01 +P01112 123 R G ? P01112 123 R G C G probably damaging alignment ? deleterious 0.999 0.00574 0.136 0.0192 NO NO ? +2.262 -1.202 -3.464 2 238 20 20 6q21 123 D 1.00 171 0.261 . B -113 0.91 -0.20 ? ? ? ? ? ? ? 1 0 1 -77 PF00071.17 3.558 ? 82.01 +P01112 123 R H ? P01112 123 R H G A probably damaging alignment ? deleterious 0.966 0.0465 0.775 0.0751 NO NO ? +1.839 -1.202 -3.041 2 238 20 20 6q21 123 D 1.00 171 0.261 . B -20 1.03 -0.20 ? ? ? ? ? ? ? 0 1 1 -78 PF00071.17 29.034 29.034 82.01 +P01112 123 R I ? P01112 123 R I ? ? probably damaging alignment ? deleterious 0.999 0.00574 0.136 0.0192 NO NO ? +2.875 -1.202 -4.077 2 238 20 20 6q21 123 D 1.00 171 0.261 . B -6 1.68 -0.20 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.207 ? 82.01 +P01112 123 R K ? P01112 123 R K ? ? probably damaging alignment ? deleterious 0.98 0.0405 0.753 0.0679 NO NO ? +1.957 -1.202 -3.159 2 238 20 20 6q21 123 D 1.00 171 0.261 . B -5 1.14 -0.20 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 3.715 ? 82.01 +P01112 123 R L ? P01112 123 R L G T probably damaging alignment ? deleterious 0.997 0.0167 0.409 0.0357 NO NO ? +2.291 -1.202 -3.493 2 238 20 20 6q21 123 D 1.00 171 0.261 . B -6 1.75 -0.20 ? ? ? ? ? ? ? 1 1 1 -78 PF00071.17 4.370 ? 82.01 +P01112 123 R M ? P01112 123 R M ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.433 -1.202 -4.635 2 238 20 20 6q21 123 D 1.00 171 0.261 . B -10 1.75 -0.20 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.197 ? 82.01 +P01112 123 R N ? P01112 123 R N ? ? probably damaging alignment ? deleterious 0.995 0.0277 0.681 0.0521 NO NO ? +2.452 -1.202 -3.654 2 238 20 20 6q21 123 D 1.00 171 0.261 . B -59 0.59 -0.20 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 5.249 ? 82.01 +P01112 123 R P ? P01112 123 R P G C probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.842 -1.202 -4.044 2 238 20 20 6q21 123 D 1.00 171 0.261 . B -61 0.68 -0.20 ? ? ? ? ? ? ? 1 1 1 -78 PF00071.17 1.746 ? 82.01 +P01112 123 R Q ? P01112 123 R Q ? ? probably damaging alignment ? deleterious 0.997 0.0167 0.409 0.0357 NO NO ? +2.525 -1.202 -3.727 2 238 20 20 6q21 123 D 1.00 171 0.261 . B -29 0.56 -0.20 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 3.282 ? 82.01 +P01112 123 R S ? P01112 123 R S C A probably damaging alignment ? deleterious 0.999 0.00574 0.136 0.0192 NO NO ? +2.331 -1.202 -3.533 2 238 20 20 6q21 123 D 1.00 171 0.261 . B -84 0.93 -0.20 ? ? ? ? ? ? ? 1 0 1 -77 PF00071.17 3.956 ? 82.01 +P01112 123 R T ? P01112 123 R T ? ? probably damaging alignment ? deleterious 0.998 0.0112 0.273 0.0274 NO NO ? +2.378 -1.202 -3.580 2 238 20 20 6q21 123 D 1.00 171 0.261 . B -57 0.98 -0.20 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.675 ? 82.01 +P01112 123 R V ? P01112 123 R V ? ? probably damaging alignment ? deleterious 0.992 0.0314 0.704 0.0568 NO NO ? +2.618 -1.202 -3.820 2 238 20 20 6q21 123 D 1.00 171 0.261 . B -33 1.64 -0.20 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.741 ? 82.01 +P01112 123 R W ? P01112 123 R W ? ? possibly damaging alignment ? deleterious 0.741 0.0787 0.853 0.111 NO NO ? +1.301 -1.202 -2.503 2 238 20 20 6q21 123 D 1.00 171 0.261 . B 54 1.67 -0.20 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 38.620 38.620 82.01 +P01112 123 R Y ? P01112 123 R Y ? ? probably damaging alignment ? deleterious 0.997 0.0167 0.409 0.0357 NO NO ? +2.788 -1.202 -3.990 2 238 20 20 6q21 123 D 1.00 171 0.261 . B 20 1.41 -0.20 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 5.297 ? 82.01 +P01112 124 T A ? P01112 124 T A A G benign alignment ? neutral 0 1 1 0.575 NO NO ? +0.304 -2.153 -2.457 2 238 20 20 6q21 124 D 1.00 171 0.482 . A -28 0.22 -0.36 ? ? ? ? ? ? ? 0 0 2 -80 PF00071.17 22.529 22.529 94.18 +P01112 124 T C ? P01112 124 T C ? ? possibly damaging alignment ? deleterious 0.642 0.0885 0.866 0.122 NO NO ? +2.891 -2.153 -5.044 2 238 20 20 6q21 124 D 1.00 171 0.482 . A -8 0.68 -0.36 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.667 ? 94.18 +P01112 124 T D ? P01112 124 T D ? ? benign alignment ? neutral 0 1 1 0.575 NO NO ? +0.867 -2.153 -3.020 2 238 20 20 6q21 124 D 1.00 171 0.482 . A -5 0.53 -0.36 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 24.769 24.769 94.18 +P01112 124 T E ? P01112 124 T E ? ? benign alignment ? neutral 0 1 1 0.575 NO NO ? +0.449 -2.153 -2.602 2 238 20 20 6q21 124 D 1.00 171 0.482 . A 22 0.82 -0.36 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 21.690 21.690 94.18 +P01112 124 T F ? P01112 124 T F ? ? possibly damaging alignment ? neutral 0.456 0.0995 0.888 0.132 NO NO ? +2.130 -2.153 -4.283 2 238 20 20 6q21 124 D 1.00 171 0.482 . A 74 0.8 -0.36 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 4.224 ? 94.18 +P01112 124 T G ? P01112 124 T G ? ? benign alignment ? neutral 0.001 0.852 0.994 0.514 NO NO ? +0.758 -2.153 -2.911 2 238 20 20 6q21 124 D 1.00 171 0.482 . A -56 0.07 -0.36 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 38.576 38.576 94.18 +P01112 124 T H ? P01112 124 T H ? ? benign alignment ? neutral 0.239 0.12 0.912 0.151 NO NO ? +2.639 -2.153 -4.792 2 238 20 20 6q21 124 D 1.00 171 0.482 . A 37 0.05 -0.36 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.627 ? 94.18 +P01112 124 T I ? P01112 124 T I C T benign alignment ? neutral 0 1 1 0.575 NO NO ? +0.930 -2.153 -3.083 2 238 20 20 6q21 124 D 1.00 171 0.482 . A 51 0.7 -0.36 ? ? ? ? ? ? ? 0 1 0 +80 PF00071.17 25.573 25.573 94.18 +P01112 124 T K ? P01112 124 T K ? ? benign alignment ? neutral 0.001 0.852 0.994 0.514 NO NO ? +0.473 -2.153 -2.626 2 238 20 20 6q21 124 D 1.00 171 0.482 . A 52 2.12 -0.36 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 15.686 15.686 94.18 +P01112 124 T L ? P01112 124 T L ? ? benign alignment ? neutral 0 1 1 0.575 NO NO ? +0.244 -2.153 -2.397 2 238 20 20 6q21 124 D 1.00 171 0.482 . A 51 0.77 -0.36 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 19.074 19.074 94.18 +P01112 124 T M ? P01112 124 T M ? ? benign alignment ? neutral 0.018 0.202 0.953 0.223 NO NO ? +1.314 -2.153 -3.467 2 238 20 20 6q21 124 D 1.00 171 0.482 . A 47 0.77 -0.36 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 12.769 12.769 94.18 +P01112 124 T N ? P01112 124 T N C A benign alignment ? neutral 0 1 1 0.575 NO NO ? +0.726 -2.153 -2.879 2 238 20 20 6q21 124 D 1.00 171 0.482 . A -2 0.39 -0.36 ? ? ? ? ? ? ? 1 1 0 +80 PF00071.17 25.975 25.975 94.18 +P01112 124 T P ? P01112 124 T P A C benign alignment ? neutral 0.093 0.148 0.931 0.177 NO NO ? +1.870 -2.153 -4.023 2 238 20 20 6q21 124 D 1.00 171 0.482 . A -4 0.3 -0.36 ? ? ? ? ? ? ? 1 0 0 -80 PF00071.17 2.465 ? 94.18 +P01112 124 T Q ? P01112 124 T Q ? ? benign alignment ? neutral 0.001 0.852 0.994 0.514 NO NO ? +0.630 -2.153 -2.783 2 238 20 20 6q21 124 D 1.00 171 0.482 . A 28 0.42 -0.36 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 15.168 15.168 94.18 +P01112 124 T R ? P01112 124 T R ? ? benign alignment ? neutral 0.107 0.143 0.928 0.173 NO NO ? +1.739 -2.153 -3.892 2 238 20 20 6q21 124 D 1.00 171 0.482 . A 57 0.98 -0.36 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 6.069 ? 94.18 +P01112 124 T S ? P01112 124 T S A T benign alignment ? neutral 0 1 1 0.575 NO NO ? +0.415 -2.153 -2.568 2 238 20 20 6q21 124 D 1.00 171 0.482 . A -27 0.05 -0.36 ? ? ? ? ? ? ? 1 0 0 -80 PF00071.17 18.618 18.618 94.18 +P01112 124 T V ? P01112 124 T V ? ? benign alignment ? neutral 0 1 1 0.575 NO NO ? +0.421 -2.153 -2.574 2 238 20 20 6q21 124 D 1.00 171 0.482 . A 24 0.66 -0.36 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 21.510 21.510 94.18 +P01112 124 T W ? P01112 124 T W ? ? possibly damaging alignment ? deleterious 0.951 0.0522 0.79 0.0823 NO NO ? +3.336 -2.153 -5.489 2 238 20 20 6q21 124 D 1.00 171 0.482 . A 111 0.69 -0.36 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 0.627 ? 94.18 +P01112 124 T Y ? P01112 124 T Y ? ? possibly damaging alignment ? deleterious 0.63 0.0891 0.868 0.122 NO NO ? +2.202 -2.153 -4.355 2 238 20 20 6q21 124 D 1.00 171 0.482 . A 77 0.43 -0.36 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.917 ? 94.18 +P01112 125 V A ? P01112 125 V A T C benign alignment ? neutral 0.427 0.103 0.892 0.135 NO NO ? +1.337 -1.193 -2.530 2 237 20 20 6q21 125 D 1.00 171 0.000 S B -52 0.44 -0.32 ? ? ? ? ? ? ? 0 1 2 +77 PF00071.17 20.690 20.690 79.89 +P01112 125 V C ? P01112 125 V C ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.584 -1.193 -4.777 2 237 20 20 6q21 125 D 1.00 171 0.000 S B -32 0.02 -0.32 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.531 ? 79.89 +P01112 125 V D ? P01112 125 V D ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.858 -1.193 -4.051 2 237 20 20 6q21 125 D 1.00 171 0.000 S B -29 1.19 -0.32 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.086 ? 79.89 +P01112 125 V E ? P01112 125 V E T A probably damaging alignment ? deleterious 0.999 0.00574 0.136 0.0192 NO NO ? +2.654 -1.193 -3.847 2 237 20 20 6q21 125 D 1.00 171 0.000 S B -2 1.48 -0.32 ? ? ? ? ? ? ? 1 1 0 +77 PF00071.17 2.876 ? 79.89 +P01112 125 V F ? P01112 125 V F ? ? possibly damaging alignment ? deleterious 0.816 0.0707 0.84 0.102 NO NO ? +1.457 -1.193 -2.650 2 237 20 20 6q21 125 D 1.00 171 0.000 S B 50 0.14 -0.32 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 29.164 29.164 79.89 +P01112 125 V G ? P01112 125 V G T G probably damaging alignment ? deleterious 0.996 0.0222 0.545 0.0439 NO NO ? +2.501 -1.193 -3.694 2 237 20 20 6q21 125 D 1.00 171 0.000 S B -80 0.73 -0.32 ? ? ? ? ? ? ? 1 1 0 +77 PF00071.17 5.597 ? 79.89 +P01112 125 V H ? P01112 125 V H ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.757 -1.193 -4.950 2 237 20 20 6q21 125 D 1.00 171 0.000 S B 13 0.61 -0.32 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.293 ? 79.89 +P01112 125 V I ? P01112 125 V I ? ? benign alignment ? neutral 0.147 0.135 0.922 0.165 NO NO ? +0.989 -1.193 -2.182 2 237 20 20 6q21 125 D 1.00 171 0.000 S B 27 0.04 -0.32 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 21.694 21.694 79.89 +P01112 125 V K ? P01112 125 V K ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.639 -1.193 -3.832 2 237 20 20 6q21 125 D 1.00 171 0.000 S B 28 2.78 -0.32 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 3.221 ? 79.89 +P01112 125 V L ? P01112 125 V L G C benign alignment ? neutral 0.104 0.144 0.928 0.174 NO NO ? +1.183 -1.193 -2.376 2 237 20 20 6q21 125 D 1.00 171 0.000 S B 27 0.11 -0.32 ? ? ? ? ? ? ? 1 0 0 +78 PF00071.17 27.617 27.617 79.89 +P01112 125 V M ? P01112 125 V M G A probably damaging alignment ? deleterious 0.991 0.0326 0.711 0.0584 NO NO ? +1.896 -1.193 -3.089 2 237 20 20 6q21 125 D 1.00 171 0.000 S B 23 0.11 -0.32 ? ? ? ? ? ? ? 0 0 0 +78 PF00071.17 12.169 12.169 79.89 +P01112 125 V N ? P01112 125 V N ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.031 -1.193 -4.224 2 237 20 20 6q21 125 D 1.00 171 0.000 S B -26 1.05 -0.32 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.876 ? 79.89 +P01112 125 V P ? P01112 125 V P ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.887 -1.193 -4.080 2 237 20 20 6q21 125 D 1.00 171 0.000 S B -28 0.96 -0.32 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.076 ? 79.89 +P01112 125 V Q ? P01112 125 V Q ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.059 -1.193 -4.252 2 237 20 20 6q21 125 D 1.00 171 0.000 S B 4 1.08 -0.32 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.225 ? 79.89 +P01112 125 V R ? P01112 125 V R ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.008 -1.193 -4.201 2 237 20 20 6q21 125 D 1.00 171 0.000 S B 33 1.64 -0.32 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.414 ? 79.89 +P01112 125 V S ? P01112 125 V S ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.472 -1.193 -3.665 2 237 20 20 6q21 125 D 1.00 171 0.000 S B -51 0.71 -0.32 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 6.018 ? 79.89 +P01112 125 V T ? P01112 125 V T ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.238 -1.193 -3.431 2 237 20 20 6q21 125 D 1.00 171 0.000 S B -24 0.66 -0.32 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 3.578 ? 79.89 +P01112 125 V W ? P01112 125 V W ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +4.074 -1.193 -5.267 2 237 20 20 6q21 125 D 1.00 171 0.000 S B 87 0.03 -0.32 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.355 ? 79.89 +P01112 125 V Y ? P01112 125 V Y ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.750 -1.193 -3.943 2 237 20 20 6q21 125 D 1.00 171 0.000 S B 53 0.23 -0.32 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 6.764 ? 79.89 +P01112 126 E A ? P01112 126 E A A C benign alignment ? neutral 0.002 0.704 0.987 0.452 NO NO ? +0.740 -2.538 -3.278 2 237 20 20 6q21 126 D 1.00 171 0.449 . B -50 1.04 -0.05 ? ? ? ? ? ? ? 1 1 0 +74 PF00071.17 8.440 ? 94.18 +P01112 126 E C ? P01112 126 E C ? ? benign alignment ? neutral 0 1 1 0.575 NO NO ? +1.029 -2.538 -3.567 2 237 20 20 6q21 126 D 1.00 171 0.449 . B -30 1.5 -0.05 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 35.544 35.544 94.18 +P01112 126 E D ? P01112 126 E D A C benign alignment ? neutral 0 1 1 0.575 NO NO ? -0.741 -2.538 -1.797 2 237 20 20 6q21 126 D 1.00 171 0.449 . B -27 0.29 -0.05 ? ? ? ? ? ? ? 1 2 0 +73 PF00071.17 37.363 37.363 94.18 +P01112 126 E F ? P01112 126 E F ? ? benign alignment ? neutral 0.271 0.116 0.909 0.148 NO NO ? +1.920 -2.538 -4.458 2 237 20 20 6q21 126 D 1.00 171 0.449 . B 52 1.62 -0.05 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.430 ? 94.18 +P01112 126 E G ? P01112 126 E G A G benign alignment ? neutral 0 1 1 0.575 NO NO ? +0.324 -2.538 -2.862 2 237 20 20 6q21 126 D 1.00 171 0.449 . B -78 0.75 -0.05 ? ? ? ? ? ? ? 0 1 0 +74 PF00071.17 39.656 39.656 94.18 +P01112 126 E H ? P01112 126 E H ? ? benign alignment ? neutral 0.001 0.852 0.994 0.514 NO NO ? +0.915 -2.538 -3.453 2 237 20 20 6q21 126 D 1.00 171 0.449 . B 15 0.87 -0.05 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 16.297 16.297 94.18 +P01112 126 E I ? P01112 126 E I ? ? benign alignment ? neutral 0.012 0.219 0.958 0.236 NO NO ? +1.539 -2.538 -4.077 2 237 20 20 6q21 126 D 1.00 171 0.449 . B 29 1.52 -0.05 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 11.294 ? 94.18 +P01112 126 E K ? P01112 126 E K G A benign alignment ? neutral 0 1 1 0.575 NO NO ? +0.448 -2.538 -2.986 2 237 20 20 6q21 126 D 1.00 171 0.449 . B 30 1.3 -0.05 ? ? ? ? ? ? ? 0 0 0 +75 PF00071.17 21.697 21.697 94.18 +P01112 126 E L ? P01112 126 E L ? ? benign alignment ? neutral 0.005 0.26 0.968 0.267 NO NO ? +1.176 -2.538 -3.714 2 237 20 20 6q21 126 D 1.00 171 0.449 . B 29 1.59 -0.05 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 8.941 ? 94.18 +P01112 126 E M ? P01112 126 E M ? ? benign alignment ? neutral 0.03 0.182 0.947 0.206 NO NO ? +2.339 -2.538 -4.877 2 237 20 20 6q21 126 D 1.00 171 0.449 . B 25 1.59 -0.05 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.181 ? 94.18 +P01112 126 E N ? P01112 126 E N ? ? benign alignment ? neutral 0 1 1 0.575 NO NO ? +0.099 -2.538 -2.637 2 237 20 20 6q21 126 D 1.00 171 0.449 . B -24 0.43 -0.05 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 24.634 24.634 94.18 +P01112 126 E P ? P01112 126 E P ? ? benign alignment ? neutral 0 1 1 0.575 NO NO ? +0.364 -2.538 -2.902 2 237 20 20 6q21 126 D 1.00 171 0.449 . B -26 0.52 -0.05 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 25.915 25.915 94.18 +P01112 126 E Q ? P01112 126 E Q G C benign alignment ? neutral 0 1 1 0.575 NO NO ? +0.656 -2.538 -3.194 2 237 20 20 6q21 126 D 1.00 171 0.449 . B 6 0.4 -0.05 ? ? ? ? ? ? ? 1 0 0 +75 PF00071.17 16.300 16.300 94.18 +P01112 126 E R ? P01112 126 E R ? ? benign alignment ? neutral 0.001 0.852 0.994 0.514 NO NO ? +0.645 -2.538 -3.183 2 237 20 20 6q21 126 D 1.00 171 0.449 . B 35 0.16 -0.05 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 17.475 17.475 94.18 +P01112 126 E S ? P01112 126 E S ? ? benign alignment ? neutral 0 1 1 0.575 NO NO ? -0.384 -2.538 -2.154 2 237 20 20 6q21 126 D 1.00 171 0.449 . B -49 0.77 -0.05 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 16.989 16.989 94.18 +P01112 126 E T ? P01112 126 E T ? ? benign alignment ? neutral 0 1 1 0.575 NO NO ? +0.068 -2.538 -2.606 2 237 20 20 6q21 126 D 1.00 171 0.449 . B -22 0.82 -0.05 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 16.394 16.394 94.18 +P01112 126 E V ? P01112 126 E V A T benign alignment ? neutral 0 1 1 0.575 NO NO ? +0.574 -2.538 -3.112 2 237 20 20 6q21 126 D 1.00 171 0.449 . B 2 1.48 -0.05 ? ? ? ? ? ? ? 1 1 0 +74 PF00071.17 18.518 18.518 94.18 +P01112 126 E W ? P01112 126 E W ? ? possibly damaging alignment ? deleterious 0.92 0.0592 0.81 0.0901 NO NO ? +3.066 -2.538 -5.604 2 237 20 20 6q21 126 D 1.00 171 0.449 . B 89 1.51 -0.05 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 0.506 ? 94.18 +P01112 126 E Y ? P01112 126 E Y ? ? benign alignment ? neutral 0.329 0.111 0.902 0.143 NO NO ? +1.879 -2.538 -4.417 2 237 20 20 6q21 126 D 1.00 171 0.449 . B 55 1.25 -0.05 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.672 ? 94.18 +P01112 127 S A ? P01112 127 S A T G benign alignment ? neutral 0 1 1 0.575 NO NO ? +0.020 -2.713 -2.733 2 237 20 20 6q21 127 D 1.00 171 0.264 H A -1 0.27 -0.90 ? ? ? ? ? ? ? 1 0 0 +72 PF00071.17 22.682 22.682 94.18 +P01112 127 S C ? P01112 127 S C C G benign alignment ? neutral 0.219 0.122 0.914 0.153 NO NO ? +2.427 -2.713 -5.140 2 237 20 20 6q21 127 D 1.00 171 0.264 H A 19 0.73 -0.90 ? ? ? ? ? ? ? 1 1 0 +71 PF00071.17 1.722 ? 94.18 +P01112 127 S D ? P01112 127 S D ? ? benign alignment ? neutral 0.011 0.222 0.959 0.239 NO NO ? +1.112 -2.713 -3.825 2 237 20 20 6q21 127 D 1.00 171 0.264 H A 22 0.48 -0.90 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 6.657 ? 94.18 +P01112 127 S E ? P01112 127 S E ? ? benign alignment ? neutral 0.001 0.852 0.994 0.514 NO NO ? +0.409 -2.713 -3.122 2 237 20 20 6q21 127 D 1.00 171 0.264 H A 49 0.77 -0.90 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 16.818 16.818 94.18 +P01112 127 S F ? P01112 127 S F C T benign alignment ? neutral 0 1 1 0.575 NO NO ? +0.698 -2.713 -3.411 2 237 20 20 6q21 127 D 1.00 171 0.264 H A 101 0.85 -0.90 ? ? ? ? ? ? ? 0 1 0 +71 PF00071.17 28.552 28.552 94.18 +P01112 127 S G ? P01112 127 S G ? ? benign alignment ? neutral 0 1 1 0.575 NO NO ? +0.334 -2.713 -3.047 2 237 20 20 6q21 127 D 1.00 171 0.264 H A -29 0.02 -0.90 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 34.800 34.800 94.18 +P01112 127 S H ? P01112 127 S H ? ? benign alignment ? neutral 0 1 1 0.575 NO NO ? +0.357 -2.713 -3.070 2 237 20 20 6q21 127 D 1.00 171 0.264 H A 64 0.1 -0.90 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 27.723 27.723 94.18 +P01112 127 S I ? P01112 127 S I ? ? benign alignment ? neutral 0.001 0.852 0.994 0.514 NO NO ? +0.316 -2.713 -3.029 2 237 20 20 6q21 127 D 1.00 171 0.264 H A 78 0.75 -0.90 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 17.240 17.240 94.18 +P01112 127 S K ? P01112 127 S K ? ? benign alignment ? neutral 0 1 1 0.575 NO NO ? +0.214 -2.713 -2.927 2 237 20 20 6q21 127 D 1.00 171 0.264 H A 79 2.07 -0.90 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 20.377 20.377 94.18 +P01112 127 S L ? P01112 127 S L ? ? benign alignment ? neutral 0 1 1 0.575 NO NO ? +0.095 -2.713 -2.808 2 237 20 20 6q21 127 D 1.00 171 0.264 H A 78 0.82 -0.90 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 25.432 25.432 94.18 +P01112 127 S M ? P01112 127 S M ? ? benign alignment ? neutral 0.008 0.239 0.963 0.252 NO NO ? +0.614 -2.713 -3.327 2 237 20 20 6q21 127 D 1.00 171 0.264 H A 74 0.82 -0.90 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 12.598 12.598 94.18 +P01112 127 S N ? P01112 127 S N ? ? benign alignment ? neutral 0 1 1 0.575 NO NO ? +0.302 -2.713 -3.015 2 237 20 20 6q21 127 D 1.00 171 0.264 H A 25 0.34 -0.90 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 25.304 25.304 94.18 +P01112 127 S P ? P01112 127 S P T C benign alignment ? neutral 0 1 1 0.575 NO NO ? -0.187 -2.713 -2.526 2 237 20 20 6q21 127 D 1.00 171 0.264 H A 23 0.25 -0.90 ? ? ? ? ? ? ? 0 0 0 +72 PF00071.17 36.123 36.123 94.18 +P01112 127 S Q ? P01112 127 S Q ? ? benign alignment ? neutral 0.003 0.556 0.981 0.39 NO NO ? +0.408 -2.713 -3.121 2 237 20 20 6q21 127 D 1.00 171 0.264 H A 55 0.37 -0.90 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 16.413 16.413 94.18 +P01112 127 S R ? P01112 127 S R ? ? benign alignment ? neutral 0.001 0.852 0.994 0.514 NO NO ? +0.351 -2.713 -3.064 2 237 20 20 6q21 127 D 1.00 171 0.264 H A 84 0.93 -0.90 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 17.111 17.111 94.18 +P01112 127 S T ? P01112 127 S T T A benign alignment ? neutral 0 1 1 0.575 NO NO ? -0.615 -2.713 -2.098 2 237 20 20 6q21 127 D 1.00 171 0.264 H A 27 0.05 -0.90 ? ? ? ? ? ? ? 1 0 0 +72 PF00071.17 23.160 23.160 94.18 +P01112 127 S V ? P01112 127 S V ? ? benign alignment ? neutral 0 1 1 0.575 NO NO ? +0.155 -2.713 -2.868 2 237 20 20 6q21 127 D 1.00 171 0.264 H A 51 0.71 -0.90 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 20.798 20.798 94.18 +P01112 127 S W ? P01112 127 S W ? ? possibly damaging alignment ? deleterious 0.809 0.0713 0.841 0.103 NO NO ? +2.740 -2.713 -5.453 2 237 20 20 6q21 127 D 1.00 171 0.264 H A 138 0.74 -0.90 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.353 ? 94.18 +P01112 127 S Y ? P01112 127 S Y C A benign alignment ? neutral 0.002 0.704 0.987 0.452 NO NO ? +0.686 -2.713 -3.399 2 237 20 20 6q21 127 D 1.00 171 0.264 H A 104 0.48 -0.90 ? ? ? ? ? ? ? 1 1 0 +71 PF00071.17 15.618 15.618 94.18 +P01112 128 R A ? P01112 128 R A ? ? benign alignment ? neutral 0 1 1 0.575 NO NO ? -0.061 -2.477 -2.416 2 237 20 20 6q21 128 D 1.00 171 0.568 H A -85 1.2 0.12 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 22.069 22.069 86.24 +P01112 128 R C ? P01112 128 R C ? ? possibly damaging alignment ? deleterious 0.773 0.0756 0.849 0.108 NO NO ? +2.671 -2.477 -5.148 2 237 20 20 6q21 128 D 1.00 171 0.568 H A -65 1.66 0.12 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.633 ? 86.24 +P01112 128 R D ? P01112 128 R D ? ? benign alignment ? neutral 0.001 0.852 0.994 0.514 NO NO ? +0.611 -2.477 -3.088 2 237 20 20 6q21 128 D 1.00 171 0.568 H A -62 0.45 0.12 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 21.830 21.830 86.24 +P01112 128 R E ? P01112 128 R E ? ? benign alignment ? neutral 0 1 1 0.575 NO NO ? +0.188 -2.477 -2.665 2 237 20 20 6q21 128 D 1.00 171 0.568 H A -35 0.16 0.12 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 22.633 22.633 86.24 +P01112 128 R F ? P01112 128 R F ? ? benign alignment ? neutral 0.401 0.105 0.895 0.137 NO NO ? +1.925 -2.477 -4.402 2 237 20 20 6q21 128 D 1.00 171 0.568 H A 17 1.78 0.12 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 4.113 ? 86.24 +P01112 128 R G ? P01112 128 R G C G benign alignment ? neutral 0.001 0.852 0.994 0.514 NO NO ? +0.285 -2.477 -2.762 2 237 20 20 6q21 128 D 1.00 171 0.568 H A -113 0.91 0.12 ? ? ? ? ? ? ? 1 0 1 +69 PF00071.17 39.116 39.116 86.24 +P01112 128 R H ? P01112 128 R H ? ? possibly damaging alignment ? deleterious 0.586 0.093 0.875 0.126 NO NO ? +2.291 -2.477 -4.768 2 237 20 20 6q21 128 D 1.00 171 0.568 H A -20 1.03 0.12 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.424 ? 86.24 +P01112 128 R I ? P01112 128 R I ? ? benign alignment ? neutral 0.018 0.202 0.953 0.223 NO NO ? +0.761 -2.477 -3.238 2 237 20 20 6q21 128 D 1.00 171 0.568 H A -6 1.68 0.12 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 12.355 12.355 86.24 +P01112 128 R K ? P01112 128 R K ? ? benign alignment ? neutral 0 1 1 0.575 NO NO ? -0.243 -2.477 -2.234 2 237 20 20 6q21 128 D 1.00 171 0.568 H A -5 1.14 0.12 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 23.896 23.896 86.24 +P01112 128 R L ? P01112 128 R L G T benign alignment ? neutral 0.001 0.852 0.994 0.514 NO NO ? +0.320 -2.477 -2.797 2 237 20 20 6q21 128 D 1.00 171 0.568 H A -6 1.75 0.12 ? ? ? ? ? ? ? 1 1 1 +68 PF00071.17 28.213 28.213 86.24 +P01112 128 R M ? P01112 128 R M ? ? benign alignment ? neutral 0.039 0.174 0.944 0.2 NO NO ? +1.094 -2.477 -3.571 2 237 20 20 6q21 128 D 1.00 171 0.568 H A -10 1.75 0.12 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 8.141 8.141 86.24 +P01112 128 R N ? P01112 128 R N ? ? benign alignment ? neutral 0.001 0.852 0.994 0.514 NO NO ? +0.283 -2.477 -2.760 2 237 20 20 6q21 128 D 1.00 171 0.568 H A -59 0.59 0.12 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 23.964 23.964 86.24 +P01112 128 R P ? P01112 128 R P G C benign alignment ? neutral 0.007 0.246 0.965 0.257 NO NO ? +0.755 -2.477 -3.232 2 237 20 20 6q21 128 D 1.00 171 0.568 H A -61 0.68 0.12 ? ? ? ? ? ? ? 1 1 3 +68 PF00071.17 37.432 37.432 86.24 +P01112 128 R Q ? P01112 128 R Q G A benign alignment ? neutral 0.045 0.169 0.942 0.196 NO NO ? +0.779 -2.477 -3.256 2 237 20 20 6q21 128 D 1.00 171 0.568 H A -29 0.56 0.12 ? ? ? ? ? ? ? 0 1 1 +68 PF00071.17 16.752 16.752 86.24 +P01112 128 R S ? P01112 128 R S ? ? benign alignment ? neutral 0.003 0.556 0.981 0.39 NO NO ? +0.313 -2.477 -2.790 2 237 20 20 6q21 128 D 1.00 171 0.568 H A -84 0.93 0.12 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 16.989 16.989 86.24 +P01112 128 R T ? P01112 128 R T ? ? benign alignment ? neutral 0 1 1 0.575 NO NO ? -0.085 -2.477 -2.392 2 237 20 20 6q21 128 D 1.00 171 0.568 H A -57 0.98 0.12 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 19.127 19.127 86.24 +P01112 128 R V ? P01112 128 R V ? ? benign alignment ? neutral 0.006 0.253 0.967 0.262 NO NO ? +0.568 -2.477 -3.045 2 237 20 20 6q21 128 D 1.00 171 0.568 H A -33 1.64 0.12 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 11.966 11.966 86.24 +P01112 128 R W ? P01112 128 R W C T probably damaging alignment ? deleterious 0.996 0.0222 0.545 0.0439 NO NO ? +3.086 -2.477 -5.563 2 237 20 20 6q21 128 D 1.00 171 0.568 H A 54 1.67 0.12 ? ? ? ? ? ? ? 0 0 1 +69 PF00071.17 0.556 ? 86.24 +P01112 128 R Y ? P01112 128 R Y ? ? possibly damaging alignment ? deleterious 0.576 0.0936 0.876 0.127 NO NO ? +1.957 -2.477 -4.434 2 237 20 20 6q21 128 D 1.00 171 0.568 H A 20 1.41 0.12 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.679 ? 86.24 +P01112 129 Q A ? P01112 129 Q A ? ? benign alignment ? neutral 0.015 0.209 0.956 0.229 NO NO ? +0.594 -2.041 -2.635 2 237 20 20 6q21 129 D 1.00 171 0.530 H A -56 0.64 -0.18 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 22.376 22.376 77.25 +P01112 129 Q C ? P01112 129 Q C ? ? probably damaging alignment ? deleterious 0.975 0.0436 0.762 0.072 NO NO ? +3.121 -2.041 -5.162 2 237 20 20 6q21 129 D 1.00 171 0.530 H A -36 1.1 -0.18 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.655 ? 77.25 +P01112 129 Q D ? P01112 129 Q D ? ? benign alignment ? neutral 0.011 0.222 0.959 0.239 NO NO ? +0.731 -2.041 -2.772 2 237 20 20 6q21 129 D 1.00 171 0.530 H A -33 0.11 -0.18 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 30.646 30.646 77.25 +P01112 129 Q E ? P01112 129 Q E C G benign alignment ? neutral 0.002 0.704 0.987 0.452 NO NO ? +0.081 -2.041 -2.122 2 237 20 20 6q21 129 D 1.00 171 0.530 H A -6 0.4 -0.18 ? ? ? ? ? ? ? 1 0 0 +66 PF00071.17 21.847 21.847 77.25 +P01112 129 Q F ? P01112 129 Q F ? ? possibly damaging alignment ? deleterious 0.905 0.0619 0.816 0.0933 NO NO ? +2.296 -2.041 -4.337 2 237 20 20 6q21 129 D 1.00 171 0.530 H A 46 1.22 -0.18 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 3.998 ? 77.25 +P01112 129 Q G ? P01112 129 Q G ? ? possibly damaging alignment ? deleterious 0.711 0.0814 0.858 0.114 NO NO ? +1.571 -2.041 -3.612 2 237 20 20 6q21 129 D 1.00 171 0.530 H A -84 0.35 -0.18 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 6.053 ? 77.25 +P01112 129 Q H ? P01112 129 Q H G C benign alignment ? neutral 0.056 0.163 0.939 0.19 NO NO ? +1.407 -2.041 -3.448 2 237 20 20 6q21 129 D 1.00 171 0.530 H A 9 0.47 -0.18 ? ? ? ? ? ? ? 1 2 2 +64 PF00071.17 26.787 26.787 77.25 +P01112 129 Q I ? P01112 129 Q I ? ? benign alignment ? neutral 0.031 0.181 0.947 0.205 NO NO ? +1.101 -2.041 -3.142 2 237 20 20 6q21 129 D 1.00 171 0.530 H A 23 1.12 -0.18 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 19.539 19.539 77.25 +P01112 129 Q K ? P01112 129 Q K C A benign alignment ? neutral 0.005 0.26 0.968 0.267 NO NO ? +0.690 -2.041 -2.731 2 237 20 20 6q21 129 D 1.00 171 0.530 H A 24 1.7 -0.18 ? ? ? ? ? ? ? 1 0 0 +66 PF00071.17 21.110 21.110 77.25 +P01112 129 Q L ? P01112 129 Q L A T benign alignment ? neutral 0.005 0.26 0.968 0.267 NO NO ? +0.390 -2.041 -2.431 2 237 20 20 6q21 129 D 1.00 171 0.530 H A 23 1.19 -0.18 ? ? ? ? ? ? ? 1 1 0 +65 PF00071.17 27.419 27.419 77.25 +P01112 129 Q M ? P01112 129 Q M ? ? possibly damaging alignment ? deleterious 0.873 0.0654 0.827 0.0968 NO NO ? +2.562 -2.041 -4.603 2 237 20 20 6q21 129 D 1.00 171 0.530 H A 19 1.19 -0.18 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 3.639 ? 77.25 +P01112 129 Q N ? P01112 129 Q N ? ? benign alignment ? neutral 0.424 0.103 0.892 0.135 NO NO ? +1.763 -2.041 -3.804 2 237 20 20 6q21 129 D 1.00 171 0.530 H A -30 0.0299999999999999 -0.18 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 5.359 ? 77.25 +P01112 129 Q P ? P01112 129 Q P A C possibly damaging alignment ? deleterious 0.888 0.064 0.822 0.0954 NO NO ? +1.973 -2.041 -4.014 2 237 20 20 6q21 129 D 1.00 171 0.530 H A -32 0.12 -0.18 ? ? ? ? ? ? ? 1 1 2 +65 PF00071.17 2.245 ? 77.25 +P01112 129 Q R ? P01112 129 Q R A G benign alignment ? neutral 0.003 0.556 0.981 0.39 NO NO ? +0.662 -2.041 -2.703 2 237 20 20 6q21 129 D 1.00 171 0.530 H A 29 0.56 -0.18 ? ? ? ? ? ? ? 0 1 2 +65 PF00071.17 25.120 25.120 77.25 +P01112 129 Q S ? P01112 129 Q S ? ? benign alignment ? neutral 0.132 0.139 0.925 0.169 NO NO ? +0.904 -2.041 -2.945 2 237 20 20 6q21 129 D 1.00 171 0.530 H A -55 0.37 -0.18 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 16.523 16.523 77.25 +P01112 129 Q T ? P01112 129 Q T ? ? benign alignment ? neutral 0.006 0.253 0.967 0.262 NO NO ? +0.752 -2.041 -2.793 2 237 20 20 6q21 129 D 1.00 171 0.530 H A -28 0.42 -0.18 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 18.476 18.476 77.25 +P01112 129 Q V ? P01112 129 Q V ? ? benign alignment ? neutral 0.004 0.408 0.975 0.328 NO NO ? +0.738 -2.041 -2.779 2 237 20 20 6q21 129 D 1.00 171 0.530 H A -4 1.08 -0.18 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 19.943 19.943 77.25 +P01112 129 Q W ? P01112 129 Q W ? ? probably damaging alignment ? deleterious 0.998 0.0112 0.273 0.0274 NO NO ? +3.455 -2.041 -5.496 2 237 20 20 6q21 129 D 1.00 171 0.530 H A 83 1.11 -0.18 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 0.540 ? 77.25 +P01112 129 Q Y ? P01112 129 Q Y ? ? possibly damaging alignment ? deleterious 0.905 0.0619 0.816 0.0933 NO NO ? +2.241 -2.041 -4.282 2 237 20 20 6q21 129 D 1.00 171 0.530 H A 49 0.85 -0.18 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 4.391 ? 77.25 +P01112 130 A C ? P01112 130 A C ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.298 -1.542 -4.840 2 236 20 20 6q21 130 D 1.00 171 0.000 H A 20 0.46 -0.93 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.432 ? 76.72 +P01112 130 A D ? P01112 130 A D C A probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.263 -1.542 -3.805 2 236 20 20 6q21 130 D 1.00 171 0.000 H A 23 0.75 -0.93 ? ? ? ? ? ? ? 1 1 0 +62 PF00071.17 2.610 ? 76.72 +P01112 130 A E ? P01112 130 A E ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.217 -1.542 -3.759 2 236 20 20 6q21 130 D 1.00 171 0.000 H A 50 1.04 -0.93 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.005 ? 76.72 +P01112 130 A F ? P01112 130 A F ? ? probably damaging alignment ? deleterious 0.998 0.0112 0.273 0.0274 NO NO ? +2.627 -1.542 -4.169 2 236 20 20 6q21 130 D 1.00 171 0.000 H A 102 0.58 -0.93 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 4.113 ? 76.72 +P01112 130 A G ? P01112 130 A G C G benign alignment ? neutral 0.002 0.704 0.987 0.452 NO NO ? -0.182 -1.542 -1.360 2 236 20 20 6q21 130 D 1.00 171 0.000 H A -28 0.29 -0.93 ? ? ? ? ? ? ? 1 1 0 +62 PF00071.17 39.116 39.116 76.72 +P01112 130 A H ? P01112 130 A H ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.338 -1.542 -4.880 2 236 20 20 6q21 130 D 1.00 171 0.000 H A 65 0.17 -0.93 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 0.991 ? 76.72 +P01112 130 A I ? P01112 130 A I ? ? possibly damaging alignment ? deleterious 0.884 0.0642 0.823 0.0956 NO NO ? +1.080 -1.542 -2.622 2 236 20 20 6q21 130 D 1.00 171 0.000 H A 79 0.48 -0.93 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 20.544 20.544 76.72 +P01112 130 A K ? P01112 130 A K ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.221 -1.542 -3.763 2 236 20 20 6q21 130 D 1.00 171 0.000 H A 80 2.34 -0.93 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.627 ? 76.72 +P01112 130 A L ? P01112 130 A L ? ? possibly damaging alignment ? deleterious 0.748 0.078 0.853 0.11 NO NO ? +1.119 -1.542 -2.661 2 236 20 20 6q21 130 D 1.00 171 0.000 H A 79 0.55 -0.93 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 28.213 28.213 76.72 +P01112 130 A M ? P01112 130 A M ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.044 -1.542 -4.586 2 236 20 20 6q21 130 D 1.00 171 0.000 H A 75 0.55 -0.93 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 3.744 ? 76.72 +P01112 130 A N ? P01112 130 A N ? ? probably damaging alignment ? deleterious 0.998 0.0112 0.273 0.0274 NO NO ? +2.344 -1.542 -3.886 2 236 20 20 6q21 130 D 1.00 171 0.000 H A 26 0.61 -0.93 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.958 ? 76.72 +P01112 130 A P ? P01112 130 A P G C probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.432 -1.542 -3.974 2 236 20 20 6q21 130 D 1.00 171 0.000 H A 24 0.52 -0.93 ? ? ? ? ? ? ? 1 0 0 +63 PF00071.17 1.411 ? 76.72 +P01112 130 A Q ? P01112 130 A Q ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.664 -1.542 -4.206 2 236 20 20 6q21 130 D 1.00 171 0.000 H A 56 0.64 -0.93 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.416 ? 76.72 +P01112 130 A R ? P01112 130 A R ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.492 -1.542 -4.034 2 236 20 20 6q21 130 D 1.00 171 0.000 H A 85 1.2 -0.93 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.838 ? 76.72 +P01112 130 A S ? P01112 130 A S G T probably damaging alignment ? deleterious 0.988 0.0353 0.727 0.0617 NO NO ? +1.775 -1.542 -3.317 2 236 20 20 6q21 130 D 1.00 171 0.000 H A 1 0.27 -0.93 ? ? ? ? ? ? ? 1 0 0 +63 PF00071.17 3.967 ? 76.72 +P01112 130 A T ? P01112 130 A T G A probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +1.992 -1.542 -3.534 2 236 20 20 6q21 130 D 1.00 171 0.000 H A 28 0.22 -0.93 ? ? ? ? ? ? ? 0 0 0 +63 PF00071.17 3.830 ? 76.72 +P01112 130 A V ? P01112 130 A V C T possibly damaging alignment ? neutral 0.485 0.098 0.885 0.13 NO NO ? +0.923 -1.542 -2.465 2 236 20 20 6q21 130 D 1.00 171 0.000 H A 52 0.44 -0.93 ? ? ? ? ? ? ? 0 1 0 +62 PF00071.17 20.655 20.655 76.72 +P01112 130 A W ? P01112 130 A W ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.815 -1.542 -5.357 2 236 20 20 6q21 130 D 1.00 171 0.000 H A 139 0.47 -0.93 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 0.556 ? 76.72 +P01112 130 A Y ? P01112 130 A Y ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.775 -1.542 -4.317 2 236 20 20 6q21 130 D 1.00 171 0.000 H A 105 0.21 -0.93 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.679 ? 76.72 +P01112 131 Q A ? P01112 131 Q A ? ? benign alignment ? neutral 0.033 0.179 0.946 0.204 NO NO ? +0.896 -1.986 -2.882 2 237 20 20 6q21 131 D 1.00 171 0.155 H A -56 0.64 -0.06 ? ? ? 4 2.845 ? ? ? ? ? ? PF00071.17 22.223 22.223 86.24 +P01112 131 Q C ? P01112 131 Q C ? ? probably damaging alignment ? deleterious 0.974 0.0438 0.763 0.0722 NO NO ? +3.273 -1.986 -5.259 2 237 20 20 6q21 131 D 1.00 171 0.155 H A -36 1.1 -0.06 ? ? ? 4 2.845 ? ? ? ? ? ? PF00071.17 1.644 ? 86.24 +P01112 131 Q D ? P01112 131 Q D ? ? benign alignment ? neutral 0.023 0.193 0.95 0.216 NO NO ? +1.048 -1.986 -3.034 2 237 20 20 6q21 131 D 1.00 171 0.155 H A -33 0.11 -0.06 ? ? ? 4 2.845 ? ? ? ? ? ? PF00071.17 28.337 28.337 86.24 +P01112 131 Q E ? P01112 131 Q E C G benign alignment ? neutral 0.005 0.26 0.968 0.267 NO NO ? +0.604 -1.986 -2.590 2 237 20 20 6q21 131 D 1.00 171 0.155 H A -6 0.4 -0.06 ? ? ? 4 2.845 ? ? 1 0 0 +60 PF00071.17 22.633 22.633 86.24 +P01112 131 Q F ? P01112 131 Q F ? ? possibly damaging alignment ? deleterious 0.821 0.07 0.839 0.102 NO NO ? +2.349 -1.986 -4.335 2 237 20 20 6q21 131 D 1.00 171 0.155 H A 46 1.22 -0.06 ? ? ? 4 2.845 ? ? ? ? ? ? PF00071.17 10.422 ? 86.24 +P01112 131 Q G ? P01112 131 Q G ? ? benign alignment ? neutral 0.033 0.179 0.946 0.204 NO NO ? +0.764 -1.986 -2.750 2 237 20 20 6q21 131 D 1.00 171 0.155 H A -84 0.35 -0.06 ? ? ? 4 2.845 ? ? ? ? ? ? PF00071.17 38.846 38.846 86.24 +P01112 131 Q H ? P01112 131 Q H G C benign alignment ? neutral 0.01 0.226 0.96 0.242 NO NO ? +0.976 -1.986 -2.962 2 237 20 20 6q21 131 D 1.00 171 0.155 H A 9 0.47 -0.06 ? ? ? 4 2.845 ? ? 1 2 2 +58 PF00071.17 30.533 30.533 86.24 +P01112 131 Q I ? P01112 131 Q I ? ? possibly damaging alignment ? deleterious 0.767 0.0763 0.851 0.108 NO NO ? +2.169 -1.986 -4.155 2 237 20 20 6q21 131 D 1.00 171 0.155 H A 23 1.12 -0.06 ? ? ? 4 2.845 ? ? ? ? ? ? PF00071.17 8.707 ? 86.24 +P01112 131 Q K ? P01112 131 Q K C A benign alignment ? neutral 0.002 0.704 0.987 0.452 NO NO ? +0.364 -1.986 -2.350 2 237 20 20 6q21 131 D 1.00 171 0.155 H A 24 1.7 -0.06 ? ? ? 4 2.845 ? ? 1 0 0 +60 PF00071.17 21.843 21.843 86.24 +P01112 131 Q L ? P01112 131 Q L A T benign alignment ? neutral 0.023 0.193 0.95 0.216 NO NO ? +1.083 -1.986 -3.069 2 237 20 20 6q21 131 D 1.00 171 0.155 H A 23 1.19 -0.06 ? ? ? 4 2.845 ? ? 1 1 0 +59 PF00071.17 28.412 28.412 86.24 +P01112 131 Q M ? P01112 131 Q M ? ? probably damaging alignment ? deleterious 0.961 0.048 0.78 0.077 NO NO ? +2.773 -1.986 -4.759 2 237 20 20 6q21 131 D 1.00 171 0.155 H A 19 1.19 -0.06 ? ? ? 4 2.845 ? ? ? ? ? ? PF00071.17 3.771 ? 86.24 +P01112 131 Q N ? P01112 131 Q N ? ? benign alignment ? neutral 0.01 0.226 0.96 0.242 NO NO ? +0.732 -1.986 -2.718 2 237 20 20 6q21 131 D 1.00 171 0.155 H A -30 0.0299999999999999 -0.06 ? ? ? 4 2.845 ? ? ? ? ? ? PF00071.17 21.450 21.450 86.24 +P01112 131 Q P ? P01112 131 Q P A C possibly damaging alignment ? deleterious 0.883 0.0643 0.823 0.0957 NO NO ? +2.068 -1.986 -4.054 2 237 20 20 6q21 131 D 1.00 171 0.155 H A -32 0.12 -0.06 ? ? ? 4 2.845 ? ? 1 1 2 +59 PF00071.17 2.249 ? 86.24 +P01112 131 Q R ? P01112 131 Q R A G benign alignment ? neutral 0.007 0.246 0.965 0.257 NO NO ? +0.755 -1.986 -2.741 2 237 20 20 6q21 131 D 1.00 171 0.155 H A 29 0.56 -0.06 ? ? ? 4 2.845 ? ? 0 1 2 +59 PF00071.17 26.941 26.941 86.24 +P01112 131 Q S ? P01112 131 Q S ? ? benign alignment ? neutral 0.127 0.14 0.925 0.17 NO NO ? +0.802 -1.986 -2.788 2 237 20 20 6q21 131 D 1.00 171 0.155 H A -55 0.37 -0.06 ? ? ? 4 2.845 ? ? ? ? ? ? PF00071.17 16.989 16.989 86.24 +P01112 131 Q T ? P01112 131 Q T ? ? benign alignment ? neutral 0.006 0.253 0.967 0.262 NO NO ? +0.877 -1.986 -2.863 2 237 20 20 6q21 131 D 1.00 171 0.155 H A -28 0.42 -0.06 ? ? ? 4 2.845 ? ? ? ? ? ? PF00071.17 18.606 18.606 86.24 +P01112 131 Q V ? P01112 131 Q V ? ? benign alignment ? neutral 0.219 0.122 0.914 0.153 NO NO ? +1.806 -1.986 -3.792 2 237 20 20 6q21 131 D 1.00 171 0.155 H A -4 1.08 -0.06 ? ? ? 4 2.845 ? ? ? ? ? ? PF00071.17 7.251 ? 86.24 +P01112 131 Q W ? P01112 131 Q W ? ? benign alignment ? neutral 0.22 0.122 0.914 0.153 NO NO ? +1.657 -1.986 -3.643 2 237 20 20 6q21 131 D 1.00 171 0.155 H A 83 1.11 -0.06 ? ? ? 4 2.845 ? ? ? ? ? ? PF00071.17 39.145 39.145 86.24 +P01112 131 Q Y ? P01112 131 Q Y ? ? benign alignment ? neutral 0.042 0.172 0.943 0.198 NO NO ? +1.343 -1.986 -3.329 2 237 20 20 6q21 131 D 1.00 171 0.155 H A 49 0.85 -0.06 ? ? ? 4 2.845 ? ? ? ? ? ? PF00071.17 25.190 25.190 86.24 +P01112 132 D A ? P01112 132 D A A C benign alignment ? neutral 0 1 1 0.575 NO NO ? +0.386 -2.098 -2.484 2 237 20 20 6q21 132 D 1.00 171 0.561 H A -23 0.75 -0.67 ? ? ? 1 5.834 ? ? 1 1 0 +56 PF00071.17 22.069 22.069 94.18 +P01112 132 D C ? P01112 132 D C ? ? possibly damaging alignment ? neutral 0.454 0.0996 0.889 0.132 NO NO ? +3.146 -2.098 -5.244 2 237 20 20 6q21 132 D 1.00 171 0.561 H A -3 1.21 -0.67 ? ? ? 1 5.834 ? ? ? ? ? ? PF00071.17 1.633 ? 94.18 +P01112 132 D E ? P01112 132 D E C G benign alignment ? neutral 0 1 1 0.575 NO NO ? -0.383 -2.098 -1.715 2 237 20 20 6q21 132 D 1.00 171 0.561 H A 27 0.29 -0.67 ? ? ? 1 5.834 ? ? 1 2 0 +55 PF00071.17 27.977 27.977 94.18 +P01112 132 D F ? P01112 132 D F ? ? possibly damaging alignment ? deleterious 0.733 0.0794 0.855 0.112 NO NO ? +2.376 -2.098 -4.474 2 237 20 20 6q21 132 D 1.00 171 0.561 H A 79 1.33 -0.67 ? ? ? 1 5.834 ? ? ? ? ? ? PF00071.17 2.372 ? 94.18 +P01112 132 D G ? P01112 132 D G A G benign alignment ? neutral 0 1 1 0.575 NO NO ? +0.395 -2.098 -2.493 2 237 20 20 6q21 132 D 1.00 171 0.561 H A -51 0.46 -0.67 ? ? ? 1 5.834 ? ? 0 1 0 +56 PF00071.17 38.307 38.307 94.18 +P01112 132 D H ? P01112 132 D H G C benign alignment ? neutral 0.002 0.704 0.987 0.452 NO NO ? +1.337 -2.098 -3.435 2 237 20 20 6q21 132 D 1.00 171 0.561 H A 42 0.58 -0.67 ? ? ? 1 5.834 ? ? 1 0 0 +57 PF00071.17 27.161 27.161 94.18 +P01112 132 D I ? P01112 132 D I ? ? benign alignment ? neutral 0.404 0.105 0.894 0.137 NO NO ? +1.999 -2.098 -4.097 2 237 20 20 6q21 132 D 1.00 171 0.561 H A 56 1.23 -0.67 ? ? ? 1 5.834 ? ? ? ? ? ? PF00071.17 8.340 ? 94.18 +P01112 132 D K ? P01112 132 D K ? ? benign alignment ? neutral 0.162 0.132 0.92 0.162 NO NO ? +1.413 -2.098 -3.511 2 237 20 20 6q21 132 D 1.00 171 0.561 H A 57 1.59 -0.67 ? ? ? 1 5.834 ? ? ? ? ? ? PF00071.17 7.668 ? 94.18 +P01112 132 D L ? P01112 132 D L ? ? benign alignment ? neutral 0.162 0.132 0.92 0.162 NO NO ? +1.628 -2.098 -3.726 2 237 20 20 6q21 132 D 1.00 171 0.561 H A 56 1.3 -0.67 ? ? ? 1 5.834 ? ? ? ? ? ? PF00071.17 6.603 ? 94.18 +P01112 132 D M ? P01112 132 D M ? ? possibly damaging alignment ? deleterious 0.795 0.073 0.845 0.105 NO NO ? +2.787 -2.098 -4.885 2 237 20 20 6q21 132 D 1.00 171 0.561 H A 52 1.3 -0.67 ? ? ? 1 5.834 ? ? ? ? ? ? PF00071.17 1.703 ? 94.18 +P01112 132 D N ? P01112 132 D N G A benign alignment ? neutral 0.001 0.852 0.994 0.514 NO NO ? +0.947 -2.098 -3.045 2 237 20 20 6q21 132 D 1.00 171 0.561 H A 3 0.14 -0.67 ? ? ? 1 5.834 ? ? 0 0 0 +57 PF00071.17 18.601 18.601 94.18 +P01112 132 D P ? P01112 132 D P ? ? benign alignment ? neutral 0 1 1 0.575 NO NO ? +0.788 -2.098 -2.886 2 237 20 20 6q21 132 D 1.00 171 0.561 H A 1 0.23 -0.67 ? ? ? 1 5.834 ? ? ? ? ? ? PF00071.17 38.741 38.741 94.18 +P01112 132 D Q ? P01112 132 D Q ? ? benign alignment ? neutral 0.004 0.408 0.975 0.328 NO NO ? +0.817 -2.098 -2.915 2 237 20 20 6q21 132 D 1.00 171 0.561 H A 33 0.11 -0.67 ? ? ? 1 5.834 ? ? ? ? ? ? PF00071.17 16.866 16.866 94.18 +P01112 132 D R ? P01112 132 D R ? ? benign alignment ? neutral 0.006 0.253 0.967 0.262 NO NO ? +1.062 -2.098 -3.160 2 237 20 20 6q21 132 D 1.00 171 0.561 H A 62 0.45 -0.67 ? ? ? 1 5.834 ? ? ? ? ? ? PF00071.17 21.844 21.844 94.18 +P01112 132 D S ? P01112 132 D S ? ? benign alignment ? neutral 0.001 0.852 0.994 0.514 NO NO ? +0.619 -2.098 -2.717 2 237 20 20 6q21 132 D 1.00 171 0.561 H A -22 0.48 -0.67 ? ? ? 1 5.834 ? ? ? ? ? ? PF00071.17 16.174 16.174 94.18 +P01112 132 D T ? P01112 132 D T ? ? benign alignment ? neutral 0 1 1 0.575 NO NO ? +0.901 -2.098 -2.999 2 237 20 20 6q21 132 D 1.00 171 0.561 H A 5 0.53 -0.67 ? ? ? 1 5.834 ? ? ? ? ? ? PF00071.17 19.387 19.387 94.18 +P01112 132 D V ? P01112 132 D V A T benign alignment ? neutral 0.002 0.704 0.987 0.452 NO NO ? +0.990 -2.098 -3.088 2 237 20 20 6q21 132 D 1.00 171 0.561 H A 29 1.19 -0.67 ? ? ? 1 5.834 ? ? 1 1 0 +56 PF00071.17 13.675 13.675 94.18 +P01112 132 D W ? P01112 132 D W ? ? probably damaging alignment ? deleterious 0.969 0.045 0.77 0.0734 NO NO ? +3.481 -2.098 -5.579 2 237 20 20 6q21 132 D 1.00 171 0.561 H A 116 1.22 -0.67 ? ? ? 1 5.834 ? ? ? ? ? ? PF00071.17 0.523 ? 94.18 +P01112 132 D Y ? P01112 132 D Y G T possibly damaging alignment ? deleterious 0.505 0.0966 0.883 0.129 NO NO ? +2.301 -2.098 -4.399 2 237 20 20 6q21 132 D 1.00 171 0.561 H A 82 0.96 -0.67 ? ? ? 1 5.834 ? ? 1 0 0 +57 PF00071.17 4.453 ? 94.18 +P01112 133 L A ? P01112 133 L A ? ? benign alignment ? neutral 0.065 0.159 0.937 0.187 NO NO ? +0.902 -1.670 -2.572 2 238 20 20 6q21 133 D 1.00 171 0.307 H A -79 0.55 -1.17 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 22.223 22.223 82.54 +P01112 133 L C ? P01112 133 L C ? ? probably damaging alignment ? deleterious 0.996 0.0222 0.545 0.0439 NO NO ? +3.241 -1.670 -4.911 2 238 20 20 6q21 133 D 1.00 171 0.307 H A -59 0.09 -1.17 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.644 ? 82.54 +P01112 133 L D ? P01112 133 L D ? ? probably damaging alignment ? deleterious 0.971 0.0444 0.768 0.0727 NO NO ? +2.403 -1.670 -4.073 2 238 20 20 6q21 133 D 1.00 171 0.307 H A -56 1.3 -1.17 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 3.706 ? 82.54 +P01112 133 L E ? P01112 133 L E ? ? probably damaging alignment ? deleterious 0.961 0.048 0.78 0.077 NO NO ? +2.183 -1.670 -3.853 2 238 20 20 6q21 133 D 1.00 171 0.307 H A -29 1.59 -1.17 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 4.511 ? 82.54 +P01112 133 L F ? P01112 133 L F C T benign alignment ? neutral 0.046 0.169 0.942 0.195 NO NO ? +1.203 -1.670 -2.873 2 238 20 20 6q21 133 D 1.00 171 0.307 H A 23 0.03 -1.17 ? ? ? ? ? ? ? 0 0 0 +54 PF00071.17 27.736 27.736 82.54 +P01112 133 L G ? P01112 133 L G ? ? possibly damaging alignment ? deleterious 0.944 0.0544 0.797 0.0847 NO NO ? +2.071 -1.670 -3.741 2 238 20 20 6q21 133 D 1.00 171 0.307 H A -107 0.84 -1.17 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 6.012 ? 82.54 +P01112 133 L H ? P01112 133 L H T A probably damaging alignment ? deleterious 0.975 0.0436 0.762 0.072 NO NO ? +3.200 -1.670 -4.870 2 238 20 20 6q21 133 D 1.00 171 0.307 H A -14 0.72 -1.17 ? ? ? ? ? ? ? 1 1 0 +53 PF00071.17 3.441 ? 82.54 +P01112 133 L I ? P01112 133 L I C A benign alignment ? neutral 0.004 0.408 0.975 0.328 NO NO ? +1.161 -1.670 -2.831 2 238 20 20 6q21 133 D 1.00 171 0.307 H A 0 0.07 -1.17 ? ? ? ? ? ? ? 1 0 0 +54 PF00071.17 20.401 20.401 82.54 +P01112 133 L K ? P01112 133 L K ? ? benign alignment ? neutral 0.02 0.198 0.952 0.22 NO NO ? +1.159 -1.670 -2.829 2 238 20 20 6q21 133 D 1.00 171 0.307 H A 1 2.89 -1.17 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 17.592 17.592 82.54 +P01112 133 L M ? P01112 133 L M ? ? benign alignment ? neutral 0.093 0.148 0.931 0.177 NO NO ? +0.991 -1.670 -2.661 2 238 20 20 6q21 133 D 1.00 171 0.307 H A -4 0 -1.17 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 12.941 12.941 82.54 +P01112 133 L N ? P01112 133 L N ? ? probably damaging alignment ? deleterious 0.971 0.0444 0.768 0.0727 NO NO ? +2.455 -1.670 -4.125 2 238 20 20 6q21 133 D 1.00 171 0.307 H A -53 1.16 -1.17 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 4.160 ? 82.54 +P01112 133 L P ? P01112 133 L P T C probably damaging alignment ? deleterious 0.981 0.0399 0.75 0.0672 NO NO ? +2.487 -1.670 -4.157 2 238 20 20 6q21 133 D 1.00 171 0.307 H A -55 1.07 -1.17 ? ? ? ? ? ? ? 0 1 0 +53 PF00071.17 2.230 ? 82.54 +P01112 133 L Q ? P01112 133 L Q ? ? possibly damaging alignment ? deleterious 0.933 0.0573 0.804 0.0882 NO NO ? +2.520 -1.670 -4.190 2 238 20 20 6q21 133 D 1.00 171 0.307 H A -23 1.19 -1.17 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 3.381 ? 82.54 +P01112 133 L R ? P01112 133 L R T G possibly damaging alignment ? deleterious 0.835 0.0687 0.836 0.1 NO NO ? +2.389 -1.670 -4.059 2 238 20 20 6q21 133 D 1.00 171 0.307 H A 6 1.75 -1.17 ? ? ? ? ? ? ? 1 1 2 +53 PF00071.17 6.806 ? 82.54 +P01112 133 L S ? P01112 133 L S ? ? benign alignment ? neutral 0.405 0.105 0.894 0.137 NO NO ? +1.322 -1.670 -2.992 2 238 20 20 6q21 133 D 1.00 171 0.307 H A -78 0.82 -1.17 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 16.640 16.640 82.54 +P01112 133 L T ? P01112 133 L T ? ? benign alignment ? neutral 0.17 0.131 0.919 0.161 NO NO ? +1.063 -1.670 -2.733 2 238 20 20 6q21 133 D 1.00 171 0.307 H A -51 0.77 -1.17 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 18.216 18.216 82.54 +P01112 133 L V ? P01112 133 L V C G benign alignment ? neutral 0 1 1 0.575 NO NO ? +0.364 -1.670 -2.034 2 238 20 20 6q21 133 D 1.00 171 0.307 H A -27 0.11 -1.17 ? ? ? ? ? ? ? 1 0 2 +54 PF00071.17 22.222 22.222 82.54 +P01112 133 L W ? P01112 133 L W ? ? probably damaging alignment ? deleterious 0.997 0.0167 0.409 0.0357 NO NO ? +3.556 -1.670 -5.226 2 238 20 20 6q21 133 D 1.00 171 0.307 H A 60 0.08 -1.17 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.007 ? 82.54 +P01112 133 L Y ? P01112 133 L Y ? ? benign alignment ? neutral 0.007 0.246 0.965 0.257 NO NO ? +1.246 -1.670 -2.916 2 238 20 20 6q21 133 D 1.00 171 0.307 H A 26 0.34 -1.17 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 23.175 23.175 82.54 +P01112 134 A C ? P01112 134 A C ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.542 -1.124 -4.666 2 238 20 20 6q21 134 D 1.00 171 0.000 H A 20 0.46 -0.58 ? ? ? 2 5.721 ? ? ? ? ? ? PF00071.17 1.399 ? 76.72 +P01112 134 A D ? P01112 134 A D C A probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.611 -1.124 -3.735 2 238 20 20 6q21 134 D 1.00 171 0.000 H A 23 0.75 -0.58 ? ? ? 2 5.721 ? ? 1 1 0 +50 PF00071.17 3.758 ? 76.72 +P01112 134 A E ? P01112 134 A E ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.460 -1.124 -3.584 2 238 20 20 6q21 134 D 1.00 171 0.000 H A 50 1.04 -0.58 ? ? ? 2 5.721 ? ? ? ? ? ? PF00071.17 3.960 ? 76.72 +P01112 134 A F ? P01112 134 A F ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.034 -1.124 -4.158 2 238 20 20 6q21 134 D 1.00 171 0.000 H A 102 0.58 -0.58 ? ? ? 2 5.721 ? ? ? ? ? ? PF00071.17 4.142 ? 76.72 +P01112 134 A G ? P01112 134 A G C G benign alignment ? neutral 0.224 0.121 0.913 0.153 NO NO ? +1.144 -1.124 -2.268 2 238 20 20 6q21 134 D 1.00 171 0.000 H A -28 0.29 -0.58 ? ? ? 2 5.721 ? ? 1 1 0 +50 PF00071.17 38.307 38.307 76.72 +P01112 134 A H ? P01112 134 A H ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.667 -1.124 -4.791 2 238 20 20 6q21 134 D 1.00 171 0.000 H A 65 0.17 -0.58 ? ? ? 2 5.721 ? ? ? ? ? ? PF00071.17 1.482 ? 76.72 +P01112 134 A I ? P01112 134 A I ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.481 -1.124 -3.605 2 238 20 20 6q21 134 D 1.00 171 0.000 H A 79 0.48 -0.58 ? ? ? 2 5.721 ? ? ? ? ? ? PF00071.17 11.815 ? 76.72 +P01112 134 A K ? P01112 134 A K ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.466 -1.124 -3.590 2 238 20 20 6q21 134 D 1.00 171 0.000 H A 80 2.34 -0.58 ? ? ? 2 5.721 ? ? ? ? ? ? PF00071.17 4.158 ? 76.72 +P01112 134 A L ? P01112 134 A L ? ? probably damaging alignment ? deleterious 0.973 0.044 0.765 0.0723 NO NO ? +1.509 -1.124 -2.633 2 238 20 20 6q21 134 D 1.00 171 0.000 H A 79 0.55 -0.58 ? ? ? 2 5.721 ? ? ? ? ? ? PF00071.17 28.412 28.412 76.72 +P01112 134 A M ? P01112 134 A M ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.414 -1.124 -4.538 2 238 20 20 6q21 134 D 1.00 171 0.000 H A 75 0.55 -0.58 ? ? ? 2 5.721 ? ? ? ? ? ? PF00071.17 3.771 ? 76.72 +P01112 134 A N ? P01112 134 A N ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.713 -1.124 -3.837 2 238 20 20 6q21 134 D 1.00 171 0.000 H A 26 0.61 -0.58 ? ? ? 2 5.721 ? ? ? ? ? ? PF00071.17 4.218 ? 76.72 +P01112 134 A P ? P01112 134 A P G C probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.723 -1.124 -3.847 2 238 20 20 6q21 134 D 1.00 171 0.000 H A 24 0.52 -0.58 ? ? ? 2 5.721 ? ? 1 0 1 +51 PF00071.17 2.234 ? 76.72 +P01112 134 A Q ? P01112 134 A Q ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.908 -1.124 -4.032 2 238 20 20 6q21 134 D 1.00 171 0.000 H A 56 0.64 -0.58 ? ? ? 2 5.721 ? ? ? ? ? ? PF00071.17 2.538 ? 76.72 +P01112 134 A R ? P01112 134 A R ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.776 -1.124 -3.900 2 238 20 20 6q21 134 D 1.00 171 0.000 H A 85 1.2 -0.58 ? ? ? 2 5.721 ? ? ? ? ? ? PF00071.17 3.038 ? 76.72 +P01112 134 A S ? P01112 134 A S G T probably damaging alignment ? deleterious 0.97 0.0446 0.769 0.0728 NO NO ? +0.960 -1.124 -2.084 2 238 20 20 6q21 134 D 1.00 171 0.000 H A 1 0.27 -0.58 ? ? ? 2 5.721 ? ? 1 0 1 +51 PF00071.17 16.872 16.872 76.72 +P01112 134 A T ? P01112 134 A T G A probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.208 -1.124 -3.332 2 238 20 20 6q21 134 D 1.00 171 0.000 H A 28 0.22 -0.58 ? ? ? 2 5.721 ? ? 0 0 1 +51 PF00071.17 6.301 ? 76.72 +P01112 134 A V ? P01112 134 A V C T probably damaging alignment ? deleterious 0.963 0.0475 0.778 0.0764 NO NO ? +1.531 -1.124 -2.655 2 238 20 20 6q21 134 D 1.00 171 0.000 H A 52 0.44 -0.58 ? ? ? 2 5.721 ? ? 0 1 0 +50 PF00071.17 19.373 19.373 76.72 +P01112 134 A W ? P01112 134 A W ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +4.281 -1.124 -5.405 2 238 20 20 6q21 134 D 1.00 171 0.000 H A 139 0.47 -0.58 ? ? ? 2 5.721 ? ? ? ? ? ? PF00071.17 0.560 ? 76.72 +P01112 134 A Y ? P01112 134 A Y ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.151 -1.124 -4.275 2 238 20 20 6q21 134 D 1.00 171 0.000 H A 105 0.21 -0.58 ? ? ? 2 5.721 ? ? ? ? ? ? PF00071.17 1.690 ? 76.72 +P01112 135 R A ? P01112 135 R A ? ? benign alignment ? neutral 0.432 0.102 0.892 0.134 NO NO ? +1.444 -1.878 -3.322 2 238 20 20 6q21 135 D 1.00 171 0.252 H A -85 1.2 0.46 ? ? ? 6 2.934 ? ? ? ? ? ? PF00071.17 6.267 ? 86.24 +P01112 135 R C ? P01112 135 R C ? ? probably damaging alignment ? deleterious 0.992 0.0314 0.704 0.0568 NO NO ? +3.404 -1.878 -5.282 2 238 20 20 6q21 135 D 1.00 171 0.252 H A -65 1.66 0.46 ? ? ? 6 2.934 ? ? ? ? ? ? PF00071.17 1.300 ? 86.24 +P01112 135 R D ? P01112 135 R D ? ? benign alignment ? neutral 0.011 0.222 0.959 0.239 NO NO ? +0.829 -1.878 -2.707 2 238 20 20 6q21 135 D 1.00 171 0.252 H A -62 0.45 0.46 ? ? ? 6 2.934 ? ? ? ? ? ? PF00071.17 31.276 31.276 86.24 +P01112 135 R E ? P01112 135 R E ? ? benign alignment ? neutral 0.003 0.556 0.981 0.39 NO NO ? +0.730 -1.878 -2.608 2 238 20 20 6q21 135 D 1.00 171 0.252 H A -35 0.16 0.46 ? ? ? 6 2.934 ? ? ? ? ? ? PF00071.17 22.790 22.790 86.24 +P01112 135 R F ? P01112 135 R F ? ? possibly damaging alignment ? deleterious 0.679 0.0846 0.862 0.117 NO NO ? +2.550 -1.878 -4.428 2 238 20 20 6q21 135 D 1.00 171 0.252 H A 17 1.78 0.46 ? ? ? 6 2.934 ? ? ? ? ? ? PF00071.17 4.490 ? 86.24 +P01112 135 R G ? P01112 135 R G C G benign alignment ? neutral 0.021 0.196 0.951 0.219 NO NO ? +0.968 -1.878 -2.846 2 238 20 20 6q21 135 D 1.00 171 0.252 H A -113 0.91 0.46 ? ? ? 6 2.934 ? ? 1 0 3 +48 PF00071.17 40.735 40.735 86.24 +P01112 135 R H ? P01112 135 R H ? ? benign alignment ? neutral 0.025 0.189 0.949 0.213 NO NO ? +1.453 -1.878 -3.331 2 238 20 20 6q21 135 D 1.00 171 0.252 H A -20 1.03 0.46 ? ? ? 6 2.934 ? ? ? ? ? ? PF00071.17 26.037 26.037 86.24 +P01112 135 R I ? P01112 135 R I ? ? possibly damaging alignment ? deleterious 0.525 0.0959 0.881 0.128 NO NO ? +2.220 -1.878 -4.098 2 238 20 20 6q21 135 D 1.00 171 0.252 H A -6 1.68 0.46 ? ? ? 6 2.934 ? ? ? ? ? ? PF00071.17 9.438 ? 86.24 +P01112 135 R K ? P01112 135 R K ? ? benign alignment ? neutral 0 1 1 0.575 NO NO ? -0.191 -1.878 -1.687 2 238 20 20 6q21 135 D 1.00 171 0.252 H A -5 1.14 0.46 ? ? ? 6 2.934 ? ? ? ? ? ? PF00071.17 23.896 23.896 86.24 +P01112 135 R L ? P01112 135 R L G T benign alignment ? neutral 0.009 0.233 0.961 0.247 NO NO ? +0.850 -1.878 -2.728 2 238 20 20 6q21 135 D 1.00 171 0.252 H A -6 1.75 0.46 ? ? ? 6 2.934 ? ? 1 1 1 +47 PF00071.17 30.796 30.796 86.24 +P01112 135 R M ? P01112 135 R M ? ? possibly damaging alignment ? deleterious 0.893 0.0634 0.821 0.0948 NO NO ? +2.830 -1.878 -4.708 2 238 20 20 6q21 135 D 1.00 171 0.252 H A -10 1.75 0.46 ? ? ? 6 2.934 ? ? ? ? ? ? PF00071.17 4.087 ? 86.24 +P01112 135 R N ? P01112 135 R N ? ? benign alignment ? neutral 0.025 0.189 0.949 0.213 NO NO ? +1.094 -1.878 -2.972 2 238 20 20 6q21 135 D 1.00 171 0.252 H A -59 0.59 0.46 ? ? ? 6 2.934 ? ? ? ? ? ? PF00071.17 20.780 20.780 86.24 +P01112 135 R P ? P01112 135 R P G C benign alignment ? neutral 0.046 0.169 0.942 0.195 NO NO ? +1.192 -1.878 -3.070 2 238 20 20 6q21 135 D 1.00 171 0.252 H A -61 0.68 0.46 ? ? ? 6 2.934 ? ? 1 1 1 +47 PF00071.17 37.170 37.170 86.24 +P01112 135 R Q ? P01112 135 R Q G A benign alignment ? neutral 0.252 0.118 0.911 0.15 NO NO ? +1.167 -1.878 -3.045 2 238 20 20 6q21 135 D 1.00 171 0.252 H A -29 0.56 0.46 ? ? ? 6 2.934 ? ? 0 1 1 +47 PF00071.17 15.620 15.620 86.24 +P01112 135 R S ? P01112 135 R S ? ? benign alignment ? neutral 0.432 0.102 0.892 0.134 NO NO ? +1.592 -1.878 -3.470 2 238 20 20 6q21 135 D 1.00 171 0.252 H A -84 0.93 0.46 ? ? ? 6 2.934 ? ? ? ? ? ? PF00071.17 4.624 ? 86.24 +P01112 135 R T ? P01112 135 R T ? ? possibly damaging alignment ? deleterious 0.603 0.0917 0.873 0.125 NO NO ? +1.773 -1.878 -3.651 2 238 20 20 6q21 135 D 1.00 171 0.252 H A -57 0.98 0.46 ? ? ? 6 2.934 ? ? ? ? ? ? PF00071.17 3.480 ? 86.24 +P01112 135 R V ? P01112 135 R V ? ? benign alignment ? neutral 0.444 0.1 0.89 0.133 NO NO ? +1.896 -1.878 -3.774 2 238 20 20 6q21 135 D 1.00 171 0.252 H A -33 1.64 0.46 ? ? ? 6 2.934 ? ? ? ? ? ? PF00071.17 7.859 ? 86.24 +P01112 135 R W ? P01112 135 R W ? ? probably damaging alignment ? deleterious 0.995 0.0277 0.681 0.0521 NO NO ? +3.645 -1.878 -5.523 2 238 20 20 6q21 135 D 1.00 171 0.252 H A 54 1.67 0.46 ? ? ? 6 2.934 ? ? ? ? ? ? PF00071.17 0.607 ? 86.24 +P01112 135 R Y ? P01112 135 R Y ? ? possibly damaging alignment ? deleterious 0.679 0.0846 0.862 0.117 NO NO ? +2.440 -1.878 -4.318 2 238 20 20 6q21 135 D 1.00 171 0.252 H A 20 1.41 0.46 ? ? ? 6 2.934 ? ? ? ? ? ? PF00071.17 4.268 ? 86.24 +P01112 136 S A ? P01112 136 S A ? ? benign alignment ? neutral 0.001 0.852 0.994 0.514 NO NO ? +0.699 -1.732 -2.431 2 237 20 20 6q21 136 D 1.00 171 0.688 H A -1 0.27 -0.72 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 22.223 22.223 82.54 +P01112 136 S C ? P01112 136 S C A T probably damaging alignment ? deleterious 0.978 0.0417 0.756 0.0695 NO NO ? +3.346 -1.732 -5.078 2 237 20 20 6q21 136 D 1.00 171 0.688 H A 19 0.73 -0.72 ? ? ? ? ? ? ? 1 0 0 +45 PF00071.17 1.644 ? 82.54 +P01112 136 S D ? P01112 136 S D ? ? benign alignment ? neutral 0.035 0.177 0.945 0.202 NO NO ? +1.241 -1.732 -2.973 2 237 20 20 6q21 136 D 1.00 171 0.688 H A 22 0.48 -0.72 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 24.349 24.349 82.54 +P01112 136 S E ? P01112 136 S E ? ? benign alignment ? neutral 0.048 0.167 0.941 0.194 NO NO ? +1.002 -1.732 -2.734 2 237 20 20 6q21 136 D 1.00 171 0.688 H A 49 0.77 -0.72 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 22.476 22.476 82.54 +P01112 136 S F ? P01112 136 S F ? ? possibly damaging alignment ? deleterious 0.583 0.0933 0.875 0.126 NO NO ? +1.562 -1.732 -3.294 2 237 20 20 6q21 136 D 1.00 171 0.688 H A 101 0.85 -0.72 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 15.908 15.908 82.54 +P01112 136 S G ? P01112 136 S G A G benign alignment ? neutral 0.022 0.195 0.951 0.217 NO NO ? +0.894 -1.732 -2.626 2 237 20 20 6q21 136 D 1.00 171 0.688 H A -29 0.02 -0.72 ? ? ? ? ? ? ? 0 0 0 +45 PF00071.17 40.195 40.195 82.54 +P01112 136 S H ? P01112 136 S H ? ? probably damaging alignment ? deleterious 0.991 0.0326 0.711 0.0584 NO NO ? +2.903 -1.732 -4.635 2 237 20 20 6q21 136 D 1.00 171 0.688 H A 64 0.1 -0.72 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.644 ? 82.54 +P01112 136 S I ? P01112 136 S I G T possibly damaging alignment ? deleterious 0.915 0.0601 0.813 0.0911 NO NO ? +2.254 -1.732 -3.986 2 237 20 20 6q21 136 D 1.00 171 0.688 H A 78 0.75 -0.72 ? ? ? ? ? ? ? 1 1 0 +44 PF00071.17 8.829 ? 82.54 +P01112 136 S K ? P01112 136 S K ? ? benign alignment ? neutral 0.366 0.108 0.898 0.14 NO NO ? +1.216 -1.732 -2.948 2 237 20 20 6q21 136 D 1.00 171 0.688 H A 79 2.07 -0.72 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 14.953 14.953 82.54 +P01112 136 S L ? P01112 136 S L ? ? benign alignment ? neutral 0.119 0.141 0.926 0.171 NO NO ? +1.039 -1.732 -2.771 2 237 20 20 6q21 136 D 1.00 171 0.688 H A 78 0.82 -0.72 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 28.809 28.809 82.54 +P01112 136 S M ? P01112 136 S M ? ? probably damaging alignment ? deleterious 0.991 0.0326 0.711 0.0584 NO NO ? +2.982 -1.732 -4.714 2 237 20 20 6q21 136 D 1.00 171 0.688 H A 74 0.82 -0.72 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 3.824 ? 82.54 +P01112 136 S N ? P01112 136 S N G A benign alignment ? neutral 0.001 0.852 0.994 0.514 NO NO ? +0.910 -1.732 -2.642 2 237 20 20 6q21 136 D 1.00 171 0.688 H A 25 0.34 -0.72 ? ? ? ? ? ? ? 0 1 0 +44 PF00071.17 26.142 26.142 82.54 +P01112 136 S P ? P01112 136 S P ? ? possibly damaging alignment ? deleterious 0.939 0.0562 0.8 0.0869 NO NO ? +2.290 -1.732 -4.022 2 237 20 20 6q21 136 D 1.00 171 0.688 H A 23 0.25 -0.72 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.230 ? 82.54 +P01112 136 S Q ? P01112 136 S Q ? ? benign alignment ? neutral 0.366 0.108 0.898 0.14 NO NO ? +1.026 -1.732 -2.758 2 237 20 20 6q21 136 D 1.00 171 0.688 H A 55 0.37 -0.72 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 16.639 16.639 82.54 +P01112 136 S R ? P01112 136 S R C A benign alignment ? neutral 0.303 0.113 0.905 0.145 NO NO ? +1.177 -1.732 -2.909 2 237 20 20 6q21 136 D 1.00 171 0.688 H A 84 0.93 -0.72 ? ? ? ? ? ? ? 1 2 0 +43 PF00071.17 15.655 15.655 82.54 +P01112 136 S T ? P01112 136 S T G C benign alignment ? neutral 0.013 0.216 0.957 0.234 NO NO ? +1.204 -1.732 -2.936 2 237 20 20 6q21 136 D 1.00 171 0.688 H A 27 0.05 -0.72 ? ? ? ? ? ? ? 1 1 0 +44 PF00071.17 17.565 17.565 82.54 +P01112 136 S V ? P01112 136 S V ? ? possibly damaging alignment ? deleterious 0.842 0.068 0.835 0.0994 NO NO ? +1.956 -1.732 -3.688 2 237 20 20 6q21 136 D 1.00 171 0.688 H A 51 0.71 -0.72 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 7.352 ? 82.54 +P01112 136 S W ? P01112 136 S W ? ? probably damaging alignment ? deleterious 0.998 0.0112 0.273 0.0274 NO NO ? +3.675 -1.732 -5.407 2 237 20 20 6q21 136 D 1.00 171 0.688 H A 138 0.74 -0.72 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.222 ? 82.54 +P01112 136 S Y ? P01112 136 S Y ? ? possibly damaging alignment ? deleterious 0.583 0.0933 0.875 0.126 NO NO ? +1.559 -1.732 -3.291 2 237 20 20 6q21 136 D 1.00 171 0.688 H A 104 0.48 -0.72 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 14.107 14.107 82.54 +P01112 137 Y A ? P01112 137 Y A ? ? possibly damaging alignment ? deleterious 0.895 0.0631 0.82 0.0945 NO NO ? +1.556 -1.832 -3.388 2 235 20 20 6q21 137 D 1.00 171 0.204 H A -105 0.21 -0.56 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 5.893 ? 85.19 +P01112 137 Y C ? P01112 137 Y C A G benign alignment ? neutral 0.341 0.11 0.9 0.142 NO NO ? +1.562 -1.832 -3.394 2 235 20 20 6q21 137 D 1.00 171 0.204 H A -85 0.25 -0.56 ? ? ? ? ? ? ? 0 1 0 +41 PF00071.17 34.521 34.521 85.19 +P01112 137 Y D ? P01112 137 Y D T G probably damaging alignment ? deleterious 0.958 0.0492 0.783 0.0785 NO NO ? +2.182 -1.832 -4.014 2 235 20 20 6q21 137 D 1.00 171 0.204 H A -82 0.96 -0.56 ? ? ? ? ? ? ? 1 0 2 +42 PF00071.17 5.952 ? 85.19 +P01112 137 Y E ? P01112 137 Y E ? ? probably damaging alignment ? deleterious 0.984 0.0381 0.743 0.065 NO NO ? +2.087 -1.832 -3.919 2 235 20 20 6q21 137 D 1.00 171 0.204 H A -55 1.25 -0.56 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 3.807 ? 85.19 +P01112 137 Y F ? P01112 137 Y F A T benign alignment ? neutral 0.002 0.704 0.987 0.452 NO NO ? +0.150 -1.832 -1.982 2 235 20 20 6q21 137 D 1.00 171 0.204 H A -3 0.37 -0.56 ? ? ? ? ? ? ? 1 1 0 +41 PF00071.17 32.835 32.835 85.19 +P01112 137 Y G ? P01112 137 Y G ? ? benign alignment ? neutral 0.22 0.122 0.914 0.153 NO NO ? +1.072 -1.832 -2.904 2 235 20 20 6q21 137 D 1.00 171 0.204 H A -133 0.5 -0.56 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 38.307 38.307 85.19 +P01112 137 Y H ? P01112 137 Y H T C benign alignment ? neutral 0.134 0.138 0.924 0.168 NO NO ? +1.448 -1.832 -3.280 2 235 20 20 6q21 137 D 1.00 171 0.204 H A -40 0.38 -0.56 ? ? ? ? ? ? ? 0 0 0 +42 PF00071.17 25.850 25.850 85.19 +P01112 137 Y I ? P01112 137 Y I ? ? benign alignment ? neutral 0.045 0.169 0.942 0.196 NO NO ? +1.124 -1.832 -2.956 2 235 20 20 6q21 137 D 1.00 171 0.204 H A -26 0.27 -0.56 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 17.240 17.240 85.19 +P01112 137 Y K ? P01112 137 Y K ? ? possibly damaging alignment ? deleterious 0.879 0.0648 0.825 0.0962 NO NO ? +2.079 -1.832 -3.911 2 235 20 20 6q21 137 D 1.00 171 0.204 H A -25 2.55 -0.56 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 3.904 ? 85.19 +P01112 137 Y L ? P01112 137 Y L ? ? benign alignment ? neutral 0.001 0.852 0.994 0.514 NO NO ? +0.278 -1.832 -2.110 2 235 20 20 6q21 137 D 1.00 171 0.204 H A -26 0.34 -0.56 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 29.604 29.604 85.19 +P01112 137 Y M ? P01112 137 Y M ? ? possibly damaging alignment ? deleterious 0.947 0.0535 0.794 0.0836 NO NO ? +2.675 -1.832 -4.507 2 235 20 20 6q21 137 D 1.00 171 0.204 H A -30 0.34 -0.56 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 3.929 ? 85.19 +P01112 137 Y N ? P01112 137 Y N T A benign alignment ? neutral 0.176 0.129 0.919 0.16 NO NO ? +1.287 -1.832 -3.119 2 235 20 20 6q21 137 D 1.00 171 0.204 H A -79 0.82 -0.56 ? ? ? ? ? ? ? 1 0 0 +42 PF00071.17 22.623 22.623 85.19 +P01112 137 Y P ? P01112 137 Y P ? ? probably damaging alignment ? deleterious 0.992 0.0314 0.704 0.0568 NO NO ? +2.468 -1.832 -4.300 2 235 20 20 6q21 137 D 1.00 171 0.204 H A -81 0.73 -0.56 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.009 ? 85.19 +P01112 137 Y Q ? P01112 137 Y Q ? ? possibly damaging alignment ? deleterious 0.947 0.0535 0.794 0.0836 NO NO ? +2.431 -1.832 -4.263 2 235 20 20 6q21 137 D 1.00 171 0.204 H A -49 0.85 -0.56 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.922 ? 85.19 +P01112 137 Y R ? P01112 137 Y R ? ? probably damaging alignment ? deleterious 0.961 0.048 0.78 0.077 NO NO ? +2.313 -1.832 -4.145 2 235 20 20 6q21 137 D 1.00 171 0.204 H A -20 1.41 -0.56 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 3.456 ? 85.19 +P01112 137 Y S ? P01112 137 Y S A C probably damaging alignment ? deleterious 0.958 0.0492 0.783 0.0785 NO NO ? +1.852 -1.832 -3.684 2 235 20 20 6q21 137 D 1.00 171 0.204 H A -104 0.48 -0.56 ? ? ? ? ? ? ? 1 1 0 +41 PF00071.17 6.988 ? 85.19 +P01112 137 Y T ? P01112 137 Y T ? ? possibly damaging alignment ? deleterious 0.548 0.0947 0.879 0.127 NO NO ? +1.145 -1.832 -2.977 2 235 20 20 6q21 137 D 1.00 171 0.204 H A -77 0.43 -0.56 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 18.606 18.606 85.19 +P01112 137 Y V ? P01112 137 Y V ? ? possibly damaging alignment ? deleterious 0.895 0.0631 0.82 0.0945 NO NO ? +1.581 -1.832 -3.413 2 235 20 20 6q21 137 D 1.00 171 0.204 H A -53 0.23 -0.56 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 11.193 ? 85.19 +P01112 137 Y W ? P01112 137 Y W ? ? benign alignment ? neutral 0.276 0.116 0.908 0.147 NO NO ? +1.498 -1.832 -3.330 2 235 20 20 6q21 137 D 1.00 171 0.204 H A 34 0.26 -0.56 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 29.162 29.162 85.19 +P01112 138 G A ? P01112 138 G A G C benign alignment ? neutral 0.106 0.144 0.928 0.173 NO NO ? +1.099 -1.395 -2.494 2 237 20 20 6q21 138 D 1.00 171 0.506 T l 28 0.29 -0.58 ? ? ? 1 3.942 ? ? 1 1 0 +38 PF00071.17 22.069 22.069 79.89 +P01112 138 G C ? P01112 138 G C G T probably damaging alignment ? deleterious 0.999 0.00574 0.136 0.0192 NO NO ? +3.763 -1.395 -5.158 2 237 20 20 6q21 138 D 1.00 171 0.506 T l 48 0.75 -0.58 ? ? ? 1 3.942 ? ? 1 0 1 +39 PF00071.17 1.633 ? 79.89 +P01112 138 G D ? P01112 138 G D G A benign alignment ? neutral 0.381 0.106 0.897 0.138 NO NO ? +1.487 -1.395 -2.882 2 237 20 20 6q21 138 D 1.00 171 0.506 T l 51 0.46 -0.58 ? ? ? 1 3.942 ? ? 0 1 0 +38 PF00071.17 29.807 29.807 79.89 +P01112 138 G E ? P01112 138 G E ? ? possibly damaging alignment ? deleterious 0.903 0.0622 0.817 0.0936 NO NO ? +1.499 -1.395 -2.894 2 237 20 20 6q21 138 D 1.00 171 0.506 T l 78 0.75 -0.58 ? ? ? 1 3.942 ? ? ? ? ? ? PF00071.17 13.517 13.517 79.89 +P01112 138 G F ? P01112 138 G F ? ? probably damaging alignment ? deleterious 0.999 0.00574 0.136 0.0192 NO NO ? +3.010 -1.395 -4.405 2 237 20 20 6q21 138 D 1.00 171 0.506 T l 130 0.87 -0.58 ? ? ? 1 3.942 ? ? ? ? ? ? PF00071.17 2.372 ? 79.89 +P01112 138 G H ? P01112 138 G H ? ? possibly damaging alignment ? deleterious 0.884 0.0642 0.823 0.0956 NO NO ? +1.931 -1.395 -3.326 2 237 20 20 6q21 138 D 1.00 171 0.506 T l 93 0.12 -0.58 ? ? ? 1 3.942 ? ? ? ? ? ? PF00071.17 27.161 27.161 79.89 +P01112 138 G I ? P01112 138 G I ? ? probably damaging alignment ? deleterious 0.99 0.0338 0.719 0.06 NO NO ? +2.693 -1.395 -4.088 2 237 20 20 6q21 138 D 1.00 171 0.506 T l 107 0.77 -0.58 ? ? ? 1 3.942 ? ? ? ? ? ? PF00071.17 10.772 ? 79.89 +P01112 138 G K ? P01112 138 G K ? ? possibly damaging alignment ? deleterious 0.685 0.0836 0.861 0.116 NO NO ? +1.512 -1.395 -2.907 2 237 20 20 6q21 138 D 1.00 171 0.506 T l 108 2.05 -0.58 ? ? ? 1 3.942 ? ? ? ? ? ? PF00071.17 20.231 20.231 79.89 +P01112 138 G L ? P01112 138 G L ? ? probably damaging alignment ? deleterious 0.99 0.0338 0.719 0.06 NO NO ? +2.310 -1.395 -3.705 2 237 20 20 6q21 138 D 1.00 171 0.506 T l 107 0.84 -0.58 ? ? ? 1 3.942 ? ? ? ? ? ? PF00071.17 8.528 ? 79.89 +P01112 138 G M ? P01112 138 G M ? ? probably damaging alignment ? deleterious 0.999 0.00574 0.136 0.0192 NO NO ? +3.478 -1.395 -4.873 2 237 20 20 6q21 138 D 1.00 171 0.506 T l 103 0.84 -0.58 ? ? ? 1 3.942 ? ? ? ? ? ? PF00071.17 2.081 ? 79.89 +P01112 138 G N ? P01112 138 G N ? ? benign alignment ? neutral 0.282 0.116 0.907 0.147 NO NO ? +0.974 -1.395 -2.369 2 237 20 20 6q21 138 D 1.00 171 0.506 T l 54 0.32 -0.58 ? ? ? 1 3.942 ? ? ? ? ? ? PF00071.17 24.969 24.969 79.89 +P01112 138 G P ? P01112 138 G P ? ? probably damaging alignment ? deleterious 0.993 0.0301 0.696 0.0553 NO NO ? +2.616 -1.395 -4.011 2 237 20 20 6q21 138 D 1.00 171 0.506 T l 52 0.23 -0.58 ? ? ? 1 3.942 ? ? ? ? ? ? PF00071.17 2.326 ? 79.89 +P01112 138 G Q ? P01112 138 G Q ? ? probably damaging alignment ? deleterious 0.995 0.0277 0.681 0.0521 NO NO ? +2.599 -1.395 -3.994 2 237 20 20 6q21 138 D 1.00 171 0.506 T l 84 0.35 -0.58 ? ? ? 1 3.942 ? ? ? ? ? ? PF00071.17 3.888 ? 79.89 +P01112 138 G R ? P01112 138 G R G C possibly damaging alignment ? deleterious 0.947 0.0535 0.794 0.0836 NO NO ? +1.428 -1.395 -2.823 2 237 20 20 6q21 138 D 1.00 171 0.506 T l 113 0.91 -0.58 ? ? ? 1 3.942 ? ? 1 0 3 +39 PF00071.17 17.111 17.111 79.89 +P01112 138 G S ? P01112 138 G S G A possibly damaging alignment ? deleterious 0.741 0.0787 0.853 0.111 NO NO ? +1.053 -1.395 -2.448 2 237 20 20 6q21 138 D 1.00 171 0.506 T l 29 0.02 -0.58 ? ? ? 1 3.942 ? ? 0 0 1 +39 PF00071.17 17.571 17.571 79.89 +P01112 138 G T ? P01112 138 G T ? ? probably damaging alignment ? deleterious 0.99 0.0338 0.719 0.06 NO NO ? +2.199 -1.395 -3.594 2 237 20 20 6q21 138 D 1.00 171 0.506 T l 56 0.07 -0.58 ? ? ? 1 3.942 ? ? ? ? ? ? PF00071.17 6.562 ? 79.89 +P01112 138 G V ? P01112 138 G V G T possibly damaging alignment ? deleterious 0.875 0.0653 0.826 0.0967 NO NO ? +1.632 -1.395 -3.027 2 237 20 20 6q21 138 D 1.00 171 0.506 T l 80 0.73 -0.58 ? ? ? 1 3.942 ? ? 1 1 0 +38 PF00071.17 17.664 17.664 79.89 +P01112 138 G W ? P01112 138 G W ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +4.074 -1.395 -5.469 2 237 20 20 6q21 138 D 1.00 171 0.506 T l 167 0.76 -0.58 ? ? ? 1 3.942 ? ? ? ? ? ? PF00071.17 0.444 ? 79.89 +P01112 138 G Y ? P01112 138 G Y ? ? probably damaging alignment ? deleterious 0.999 0.00574 0.136 0.0192 NO NO ? +2.974 -1.395 -4.369 2 237 20 20 6q21 138 D 1.00 171 0.506 T l 133 0.5 -0.58 ? ? ? 1 3.942 ? ? ? ? ? ? PF00071.17 4.453 ? 79.89 +P01112 139 I A ? P01112 139 I A ? ? possibly damaging structure 1.1.3 neutral 0.485 0.098 0.885 0.13 NO NO ? +0.883 -1.753 -2.636 2 237 20 20 6q21 139 D 1.00 171 0.053 . B -79 0.48 -1.00 ? ? ? 2 4.165 ? ? ? ? ? ? PF00071.17 14.713 14.713 80.95 +P01112 139 I C ? P01112 139 I C ? ? benign alignment ? neutral 0.18 0.129 0.918 0.16 NO NO ? +0.981 -1.753 -2.734 2 237 20 20 6q21 139 D 1.00 171 0.053 . B -59 0.02 -1.00 ? ? ? 2 4.165 ? ? ? ? ? ? PF00071.17 32.220 32.220 80.95 +P01112 139 I D ? P01112 139 I D ? ? probably damaging alignment ? deleterious 0.991 0.0326 0.711 0.0584 NO NO ? +2.308 -1.753 -4.061 2 237 20 20 6q21 139 D 1.00 171 0.053 . B -56 1.23 -1.00 ? ? ? 2 4.165 ? ? ? ? ? ? PF00071.17 3.266 ? 80.95 +P01112 139 I E ? P01112 139 I E ? ? probably damaging alignment ? deleterious 0.987 0.036 0.731 0.0626 NO NO ? +2.185 -1.753 -3.938 2 237 20 20 6q21 139 D 1.00 171 0.053 . B -29 1.52 -1.00 ? ? ? 2 4.165 ? ? ? ? ? ? PF00071.17 3.441 ? 80.95 +P01112 139 I F ? P01112 139 I F A T benign alignment ? neutral 0.131 0.139 0.925 0.169 NO NO ? +1.296 -1.753 -3.049 2 237 20 20 6q21 139 D 1.00 171 0.053 . B 23 0.1 -1.00 ? ? ? 2 4.165 ? ? 1 0 0 +36 PF00071.17 26.513 26.513 80.95 +P01112 139 I G ? P01112 139 I G ? ? probably damaging alignment ? deleterious 0.991 0.0326 0.711 0.0584 NO NO ? +1.988 -1.753 -3.741 2 237 20 20 6q21 139 D 1.00 171 0.053 . B -107 0.77 -1.00 ? ? ? 2 4.165 ? ? ? ? ? ? PF00071.17 4.467 ? 80.95 +P01112 139 I H ? P01112 139 I H ? ? probably damaging alignment ? deleterious 0.999 0.00574 0.136 0.0192 NO NO ? +3.250 -1.753 -5.003 2 237 20 20 6q21 139 D 1.00 171 0.053 . B -14 0.65 -1.00 ? ? ? 2 4.165 ? ? ? ? ? ? PF00071.17 1.287 ? 80.95 +P01112 139 I K ? P01112 139 I K ? ? possibly damaging alignment ? deleterious 0.758 0.077 0.852 0.109 NO NO ? +2.144 -1.753 -3.897 2 237 20 20 6q21 139 D 1.00 171 0.053 . B 1 2.82 -1.00 ? ? ? 2 4.165 ? ? ? ? ? ? PF00071.17 3.613 ? 80.95 +P01112 139 I L ? P01112 139 I L A C benign alignment ? neutral 0.002 0.704 0.987 0.452 NO NO ? +0.574 -1.753 -2.327 2 237 20 20 6q21 139 D 1.00 171 0.053 . B 0 0.07 -1.00 ? ? ? 2 4.165 ? ? 1 0 0 +36 PF00071.17 28.412 28.412 80.95 +P01112 139 I M ? P01112 139 I M C G benign alignment ? neutral 0.361 0.108 0.898 0.14 NO NO ? +1.194 -1.753 -2.947 2 237 20 20 6q21 139 D 1.00 171 0.053 . B -4 0.07 -1.00 ? ? ? 2 4.165 ? ? 1 2 0 +34 PF00071.17 12.255 12.255 80.95 +P01112 139 I N ? P01112 139 I N T A probably damaging alignment ? deleterious 0.988 0.0353 0.727 0.0617 NO NO ? +2.452 -1.753 -4.205 2 237 20 20 6q21 139 D 1.00 171 0.053 . B -53 1.09 -1.00 ? ? ? 2 4.165 ? ? 1 1 0 +35 PF00071.17 3.666 ? 80.95 +P01112 139 I P ? P01112 139 I P ? ? probably damaging alignment ? deleterious 0.995 0.0277 0.681 0.0521 NO NO ? +2.410 -1.753 -4.163 2 237 20 20 6q21 139 D 1.00 171 0.053 . B -55 1 -1.00 ? ? ? 2 4.165 ? ? ? ? ? ? PF00071.17 1.941 ? 80.95 +P01112 139 I Q ? P01112 139 I Q ? ? probably damaging alignment ? deleterious 0.989 0.0346 0.723 0.0608 NO NO ? +2.560 -1.753 -4.313 2 237 20 20 6q21 139 D 1.00 171 0.053 . B -23 1.12 -1.00 ? ? ? 2 4.165 ? ? ? ? ? ? PF00071.17 2.240 ? 80.95 +P01112 139 I R ? P01112 139 I R ? ? probably damaging alignment ? deleterious 0.977 0.0424 0.758 0.0704 NO NO ? +2.473 -1.753 -4.226 2 237 20 20 6q21 139 D 1.00 171 0.053 . B 6 1.68 -1.00 ? ? ? 2 4.165 ? ? ? ? ? ? PF00071.17 2.640 ? 80.95 +P01112 139 I S ? P01112 139 I S T G possibly damaging structure 1.1.1 deleterious 0.619 0.0903 0.87 0.123 NO NO ? +1.187 -1.753 -2.940 2 237 20 20 6q21 139 D 1.00 171 0.053 . B -78 0.75 -1.00 ? ? ? 2 4.165 ? ? 1 1 0 +35 PF00071.17 14.661 14.661 80.95 +P01112 139 I T ? P01112 139 I T T C possibly damaging alignment ? deleterious 0.775 0.0753 0.849 0.107 NO NO ? +1.761 -1.753 -3.514 2 237 20 20 6q21 139 D 1.00 171 0.053 . B -51 0.7 -1.00 ? ? ? 2 4.165 ? ? 0 1 0 +35 PF00071.17 5.476 ? 80.95 +P01112 139 I V ? P01112 139 I V A G benign alignment ? neutral 0 1 1 0.575 NO NO ? -0.075 -1.753 -1.678 2 237 20 20 6q21 139 D 1.00 171 0.053 . B -27 0.04 -1.00 ? ? ? 2 4.165 ? ? 0 0 2 +36 PF00071.17 21.795 21.795 80.95 +P01112 139 I W ? P01112 139 I W ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.598 -1.753 -5.351 2 237 20 20 6q21 139 D 1.00 171 0.053 . B 60 0.01 -1.00 ? ? ? 2 4.165 ? ? ? ? ? ? PF00071.17 1.232 ? 80.95 +P01112 139 I Y ? P01112 139 I Y ? ? possibly damaging alignment ? deleterious 0.713 0.0812 0.858 0.114 NO NO ? +2.341 -1.753 -4.094 2 237 20 20 6q21 139 D 1.00 171 0.053 . B 26 0.27 -1.00 ? ? ? 2 4.165 ? ? ? ? ? ? PF00071.17 6.149 ? 80.95 +P01112 140 P A ? P01112 140 P A C G possibly damaging alignment ? deleterious 0.878 0.0649 0.825 0.0963 NO NO ? +1.404 -1.119 -2.523 2 236 20 20 6q21 140 D 1.00 171 0.000 . B -24 0.52 -0.91 ? ? ? 3 3.553 ? ? 1 0 2 +33 PF00071.17 20.843 20.843 83.60 +P01112 140 P C ? P01112 140 P C ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.935 -1.119 -5.054 2 236 20 20 6q21 140 D 1.00 171 0.000 . B -4 0.98 -0.91 ? ? ? 3 3.553 ? ? ? ? ? ? PF00071.17 1.542 ? 83.60 +P01112 140 P D ? P01112 140 P D ? ? possibly damaging alignment ? deleterious 0.902 0.0624 0.817 0.0938 NO NO ? +2.421 -1.119 -3.540 2 236 20 20 6q21 140 D 1.00 171 0.000 . B -1 0.23 -0.91 ? ? ? 3 3.553 ? ? ? ? ? ? PF00071.17 7.566 ? 83.60 +P01112 140 P E ? P01112 140 P E ? ? possibly damaging alignment ? deleterious 0.912 0.0606 0.814 0.0916 NO NO ? +1.597 -1.119 -2.716 2 236 20 20 6q21 140 D 1.00 171 0.000 . B 26 0.52 -0.91 ? ? ? 3 3.553 ? ? ? ? ? ? PF00071.17 24.834 24.834 83.60 +P01112 140 P F ? P01112 140 P F ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.290 -1.119 -4.409 2 236 20 20 6q21 140 D 1.00 171 0.000 . B 78 1.1 -0.91 ? ? ? 3 3.553 ? ? ? ? ? ? PF00071.17 3.563 ? 83.60 +P01112 140 P G ? P01112 140 P G ? ? probably damaging alignment ? deleterious 0.999 0.00574 0.136 0.0192 NO NO ? +2.281 -1.119 -3.400 2 236 20 20 6q21 140 D 1.00 171 0.000 . B -52 0.23 -0.91 ? ? ? 3 3.553 ? ? ? ? ? ? PF00071.17 5.639 ? 83.60 +P01112 140 P H ? P01112 140 P H C A probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.607 -1.119 -4.726 2 236 20 20 6q21 140 D 1.00 171 0.000 . B 41 0.35 -0.91 ? ? ? 3 3.553 ? ? 1 1 0 +32 PF00071.17 2.104 ? 83.60 +P01112 140 P I ? P01112 140 P I ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.805 -1.119 -3.924 2 236 20 20 6q21 140 D 1.00 171 0.000 . B 55 1 -0.91 ? ? ? 3 3.553 ? ? ? ? ? ? PF00071.17 7.489 ? 83.60 +P01112 140 P K ? P01112 140 P K ? ? probably damaging structure 1.1.1 deleterious 0.999 0.00574 0.136 0.0192 NO NO ? +1.601 -1.119 -2.720 2 236 20 20 6q21 140 D 1.00 171 0.000 . B 56 1.82 -0.91 ? ? ? 3 3.553 ? ? ? ? ? ? PF00071.17 14.953 14.953 83.60 +P01112 140 P L ? P01112 140 P L C T probably damaging structure 1.1.1 deleterious 0.989 0.0346 0.723 0.0608 NO NO ? +1.625 -1.119 -2.744 2 236 20 20 6q21 140 D 1.00 171 0.000 . B 55 1.07 -0.91 ? ? ? 3 3.553 ? ? 0 1 0 +32 PF00071.17 24.438 24.438 83.60 +P01112 140 P M ? P01112 140 P M ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.542 -1.119 -4.661 2 236 20 20 6q21 140 D 1.00 171 0.000 . B 51 1.07 -0.91 ? ? ? 3 3.553 ? ? ? ? ? ? PF00071.17 3.243 ? 83.60 +P01112 140 P N ? P01112 140 P N ? ? probably damaging alignment ? deleterious 0.991 0.0326 0.711 0.0584 NO NO ? +2.733 -1.119 -3.852 2 236 20 20 6q21 140 D 1.00 171 0.000 . B 2 0.09 -0.91 ? ? ? 3 3.553 ? ? ? ? ? ? PF00071.17 4.131 ? 83.60 +P01112 140 P Q ? P01112 140 P Q ? ? probably damaging alignment ? deleterious 0.998 0.0112 0.273 0.0274 NO NO ? +2.778 -1.119 -3.897 2 236 20 20 6q21 140 D 1.00 171 0.000 . B 32 0.12 -0.91 ? ? ? 3 3.553 ? ? ? ? ? ? PF00071.17 5.447 ? 83.60 +P01112 140 P R ? P01112 140 P R C G probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.750 -1.119 -3.869 2 236 20 20 6q21 140 D 1.00 171 0.000 . B 61 0.68 -0.91 ? ? ? 3 3.553 ? ? 1 1 2 +32 PF00071.17 5.785 ? 83.60 +P01112 140 P S ? P01112 140 P S C T possibly damaging alignment ? deleterious 0.911 0.0607 0.814 0.0918 NO NO ? +1.352 -1.119 -2.471 2 236 20 20 6q21 140 D 1.00 171 0.000 . B -23 0.25 -0.91 ? ? ? 3 3.553 ? ? 0 0 0 +33 PF00071.17 16.523 16.523 83.60 +P01112 140 P T ? P01112 140 P T C A probably damaging alignment ? deleterious 0.991 0.0326 0.711 0.0584 NO NO ? +2.341 -1.119 -3.460 2 236 20 20 6q21 140 D 1.00 171 0.000 . B 4 0.3 -0.91 ? ? ? 3 3.553 ? ? 1 0 0 +33 PF00071.17 6.171 ? 83.60 +P01112 140 P V ? P01112 140 P V ? ? probably damaging alignment ? deleterious 0.999 0.00574 0.136 0.0192 NO NO ? +2.419 -1.119 -3.538 2 236 20 20 6q21 140 D 1.00 171 0.000 . B 28 0.96 -0.91 ? ? ? 3 3.553 ? ? ? ? ? ? PF00071.17 6.237 ? 83.60 +P01112 140 P W ? P01112 140 P W ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +4.427 -1.119 -5.546 2 236 20 20 6q21 140 D 1.00 171 0.000 . B 115 0.99 -0.91 ? ? ? 3 3.553 ? ? ? ? ? ? PF00071.17 0.482 ? 83.60 +P01112 140 P Y ? P01112 140 P Y ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.267 -1.119 -4.386 2 236 20 20 6q21 140 D 1.00 171 0.000 . B 81 0.73 -0.91 ? ? ? 3 3.553 ? ? ? ? ? ? PF00071.17 1.454 ? 83.60 +P01112 141 Y A ? P01112 141 Y A ? ? benign structure 1.1.3 neutral 0.006 0.253 0.967 0.262 NO NO ? +0.799 -1.965 -2.764 2 236 20 20 6q21 141 D 1.00 171 0.105 E B -105 0.21 -1.35 ? ? ? 2 3.017 ? ? ? ? ? ? PF00071.17 21.916 21.916 94.18 +P01112 141 Y C ? P01112 141 Y C A G benign structure 1.1.3 neutral 0.024 0.191 0.95 0.214 NO NO ? +1.411 -1.965 -3.376 2 236 20 20 6q21 141 D 1.00 171 0.105 E B -85 0.25 -1.35 ? ? ? 2 3.017 ? ? 0 1 0 +29 PF00071.17 36.567 36.567 94.18 +P01112 141 Y D ? P01112 141 Y D T G possibly damaging alignment ? deleterious 0.521 0.096 0.882 0.129 NO NO ? +2.039 -1.965 -4.004 2 236 20 20 6q21 141 D 1.00 171 0.105 E B -82 0.96 -1.35 ? ? ? 2 3.017 ? ? 1 0 2 +30 PF00071.17 6.172 ? 94.18 +P01112 141 Y E ? P01112 141 Y E ? ? possibly damaging alignment ? deleterious 0.742 0.0786 0.853 0.111 NO NO ? +1.942 -1.965 -3.907 2 236 20 20 6q21 141 D 1.00 171 0.105 E B -55 1.25 -1.35 ? ? ? 2 3.017 ? ? ? ? ? ? PF00071.17 3.666 ? 94.18 +P01112 141 Y F ? P01112 141 Y F A T benign alignment ? neutral 0 1 1 0.575 NO NO ? -0.341 -1.965 -1.624 2 236 20 20 6q21 141 D 1.00 171 0.105 E B -3 0.37 -1.35 ? ? ? 2 3.017 ? ? 1 1 0 +29 PF00071.17 36.302 36.302 94.18 +P01112 141 Y G ? P01112 141 Y G ? ? benign alignment ? neutral 0.291 0.114 0.907 0.146 NO NO ? +1.702 -1.965 -3.667 2 236 20 20 6q21 141 D 1.00 171 0.105 E B -133 0.5 -1.35 ? ? ? 2 3.017 ? ? ? ? ? ? PF00071.17 5.929 ? 94.18 +P01112 141 Y H ? P01112 141 Y H T C possibly damaging alignment ? deleterious 0.57 0.0938 0.876 0.127 NO NO ? +2.570 -1.965 -4.535 2 236 20 20 6q21 141 D 1.00 171 0.105 E B -40 0.38 -1.35 ? ? ? 2 3.017 ? ? 0 0 0 +30 PF00071.17 2.373 ? 94.18 +P01112 141 Y I ? P01112 141 Y I ? ? benign alignment ? neutral 0.001 0.852 0.994 0.514 NO NO ? +0.933 -1.965 -2.898 2 236 20 20 6q21 141 D 1.00 171 0.105 E B -26 0.27 -1.35 ? ? ? 2 3.017 ? ? ? ? ? ? PF00071.17 17.815 17.815 94.18 +P01112 141 Y K ? P01112 141 Y K ? ? benign alignment ? neutral 0.259 0.118 0.91 0.149 NO NO ? +1.926 -1.965 -3.891 2 236 20 20 6q21 141 D 1.00 171 0.105 E B -25 2.55 -1.35 ? ? ? 2 3.017 ? ? ? ? ? ? PF00071.17 4.049 ? 94.18 +P01112 141 Y L ? P01112 141 Y L ? ? benign alignment ? neutral 0 1 1 0.575 NO NO ? +0.692 -1.965 -2.657 2 236 20 20 6q21 141 D 1.00 171 0.105 E B -26 0.34 -1.35 ? ? ? 2 3.017 ? ? ? ? ? ? PF00071.17 26.823 26.823 94.18 +P01112 141 Y M ? P01112 141 Y M ? ? benign alignment ? neutral 0.049 0.167 0.941 0.193 NO NO ? +1.355 -1.965 -3.320 2 236 20 20 6q21 141 D 1.00 171 0.105 E B -30 0.34 -1.35 ? ? ? 2 3.017 ? ? ? ? ? ? PF00071.17 8.227 8.227 94.18 +P01112 141 Y N ? P01112 141 Y N T A benign structure 1.1.1 neutral 0.01 0.226 0.96 0.242 NO NO ? +1.170 -1.965 -3.135 2 236 20 20 6q21 141 D 1.00 171 0.105 E B -79 0.82 -1.35 ? ? ? 2 3.017 ? ? 1 0 0 +30 PF00071.17 23.461 23.461 94.18 +P01112 141 Y P ? P01112 141 Y P ? ? possibly damaging alignment ? deleterious 0.854 0.0672 0.832 0.0986 NO NO ? +2.309 -1.965 -4.274 2 236 20 20 6q21 141 D 1.00 171 0.105 E B -81 0.73 -1.35 ? ? ? 2 3.017 ? ? ? ? ? ? PF00071.17 2.199 ? 94.18 +P01112 141 Y Q ? P01112 141 Y Q ? ? possibly damaging alignment ? deleterious 0.637 0.0889 0.867 0.122 NO NO ? +2.299 -1.965 -4.264 2 236 20 20 6q21 141 D 1.00 171 0.105 E B -49 0.85 -1.35 ? ? ? 2 3.017 ? ? ? ? ? ? PF00071.17 2.539 ? 94.18 +P01112 141 Y R ? P01112 141 Y R ? ? possibly damaging alignment ? deleterious 0.545 0.0948 0.879 0.127 NO NO ? +2.210 -1.965 -4.175 2 236 20 20 6q21 141 D 1.00 171 0.105 E B -20 1.41 -1.35 ? ? ? 2 3.017 ? ? ? ? ? ? PF00071.17 3.283 ? 94.18 +P01112 141 Y S ? P01112 141 Y S A C benign structure 1.1.3 neutral 0.114 0.142 0.927 0.172 NO NO ? +0.995 -1.965 -2.960 2 236 20 20 6q21 141 D 1.00 171 0.105 E B -104 0.48 -1.35 ? ? ? 2 3.017 ? ? 1 1 0 +29 PF00071.17 12.102 12.102 94.18 +P01112 141 Y T ? P01112 141 Y T ? ? benign alignment ? neutral 0.291 0.114 0.907 0.146 NO NO ? +1.699 -1.965 -3.664 2 236 20 20 6q21 141 D 1.00 171 0.105 E B -77 0.43 -1.35 ? ? ? 2 3.017 ? ? ? ? ? ? PF00071.17 4.520 ? 94.18 +P01112 141 Y V ? P01112 141 Y V ? ? benign alignment ? neutral 0.003 0.556 0.981 0.39 NO NO ? +0.640 -1.965 -2.605 2 236 20 20 6q21 141 D 1.00 171 0.105 E B -53 0.23 -1.35 ? ? ? 2 3.017 ? ? ? ? ? ? PF00071.17 22.080 22.080 94.18 +P01112 141 Y W ? P01112 141 Y W ? ? possibly damaging alignment ? deleterious 0.925 0.0583 0.808 0.089 NO NO ? +2.875 -1.965 -4.840 2 236 20 20 6q21 141 D 1.00 171 0.105 E B 34 0.26 -1.35 ? ? ? 2 3.017 ? ? ? ? ? ? PF00071.17 1.687 ? 94.18 +P01112 142 I A ? P01112 142 I A ? ? possibly damaging alignment ? deleterious 0.61 0.0911 0.872 0.124 NO NO ? +1.288 -1.968 -3.256 2 236 20 20 6q21 142 D 1.00 171 0.173 E B -79 0.48 -1.17 ? ? ? 2 3.888 ? ? ? ? ? ? PF00071.17 5.810 ? 83.60 +P01112 142 I C ? P01112 142 I C ? ? probably damaging alignment ? deleterious 0.998 0.0112 0.273 0.0274 NO NO ? +2.984 -1.968 -4.952 2 236 20 20 6q21 142 D 1.00 171 0.173 E B -59 0.02 -1.17 ? ? ? 2 3.888 ? ? ? ? ? ? PF00071.17 1.560 ? 83.60 +P01112 142 I D ? P01112 142 I D ? ? possibly damaging alignment ? deleterious 0.93 0.0578 0.805 0.0887 NO NO ? +1.991 -1.968 -3.959 2 236 20 20 6q21 142 D 1.00 171 0.173 E B -56 1.23 -1.17 ? ? ? 2 3.888 ? ? ? ? ? ? PF00071.17 6.465 ? 83.60 +P01112 142 I E ? P01112 142 I E ? ? benign alignment ? neutral 0.085 0.151 0.932 0.18 NO NO ? +1.063 -1.968 -3.031 2 236 20 20 6q21 142 D 1.00 171 0.173 E B -29 1.52 -1.17 ? ? ? 2 3.888 ? ? ? ? ? ? PF00071.17 21.219 21.219 83.60 +P01112 142 I F ? P01112 142 I F A T benign alignment ? neutral 0.007 0.246 0.965 0.257 NO NO ? +0.690 -1.968 -2.658 2 236 20 20 6q21 142 D 1.00 171 0.173 E B 23 0.1 -1.17 ? ? ? 2 3.888 ? ? 1 0 0 +27 PF00071.17 25.697 25.697 83.60 +P01112 142 I G ? P01112 142 I G ? ? probably damaging alignment ? deleterious 0.964 0.0472 0.777 0.0761 NO NO ? +1.854 -1.968 -3.822 2 236 20 20 6q21 142 D 1.00 171 0.173 E B -107 0.77 -1.17 ? ? ? 2 3.888 ? ? ? ? ? ? PF00071.17 3.085 ? 83.60 +P01112 142 I H ? P01112 142 I H ? ? benign alignment ? neutral 0.112 0.142 0.927 0.172 NO NO ? +1.441 -1.968 -3.409 2 236 20 20 6q21 142 D 1.00 171 0.173 E B -14 0.65 -1.17 ? ? ? 2 3.888 ? ? ? ? ? ? PF00071.17 21.729 21.729 83.60 +P01112 142 I K ? P01112 142 I K ? ? benign alignment ? neutral 0.281 0.116 0.908 0.147 NO NO ? +1.840 -1.968 -3.808 2 236 20 20 6q21 142 D 1.00 171 0.173 E B 1 2.82 -1.17 ? ? ? 2 3.888 ? ? ? ? ? ? PF00071.17 6.983 ? 83.60 +P01112 142 I L ? P01112 142 I L A C benign alignment ? neutral 0 1 1 0.575 NO NO ? +0.073 -1.968 -2.041 2 236 20 20 6q21 142 D 1.00 171 0.173 E B 0 0.07 -1.17 ? ? ? 2 3.888 ? ? 1 0 0 +27 PF00071.17 28.412 28.412 83.60 +P01112 142 I M ? P01112 142 I M C G benign alignment ? neutral 0.264 0.117 0.91 0.149 NO NO ? +1.048 -1.968 -3.016 2 236 20 20 6q21 142 D 1.00 171 0.173 E B -4 0.07 -1.17 ? ? ? 2 3.888 ? ? 1 2 1 +25 PF00071.17 11.484 11.484 83.60 +P01112 142 I N ? P01112 142 I N T A possibly damaging alignment ? deleterious 0.952 0.0518 0.789 0.0817 NO NO ? +2.148 -1.968 -4.116 2 236 20 20 6q21 142 D 1.00 171 0.173 E B -53 1.09 -1.17 ? ? ? 2 3.888 ? ? 1 1 0 +26 PF00071.17 3.451 ? 83.60 +P01112 142 I P ? P01112 142 I P ? ? probably damaging alignment ? deleterious 0.982 0.0393 0.748 0.0664 NO NO ? +2.201 -1.968 -4.169 2 236 20 20 6q21 142 D 1.00 171 0.173 E B -55 1 -1.17 ? ? ? 2 3.888 ? ? ? ? ? ? PF00071.17 1.909 ? 83.60 +P01112 142 I Q ? P01112 142 I Q ? ? benign alignment ? neutral 0.089 0.149 0.932 0.178 NO NO ? +0.990 -1.968 -2.958 2 236 20 20 6q21 142 D 1.00 171 0.173 E B -23 1.12 -1.17 ? ? ? 2 3.888 ? ? ? ? ? ? PF00071.17 16.526 16.526 83.60 +P01112 142 I R ? P01112 142 I R ? ? possibly damaging alignment ? deleterious 0.841 0.0682 0.836 0.0995 NO NO ? +2.141 -1.968 -4.109 2 236 20 20 6q21 142 D 1.00 171 0.173 E B 6 1.68 -1.17 ? ? ? 2 3.888 ? ? ? ? ? ? PF00071.17 5.605 ? 83.60 +P01112 142 I S ? P01112 142 I S T G possibly damaging alignment ? deleterious 0.741 0.0787 0.853 0.111 NO NO ? +1.726 -1.968 -3.694 2 236 20 20 6q21 142 D 1.00 171 0.173 E B -78 0.75 -1.17 ? ? ? 2 3.888 ? ? 1 1 0 +26 PF00071.17 6.011 ? 83.60 +P01112 142 I T ? P01112 142 I T T C benign alignment ? neutral 0.051 0.165 0.941 0.192 NO NO ? +0.962 -1.968 -2.930 2 236 20 20 6q21 142 D 1.00 171 0.173 E B -51 0.7 -1.17 ? ? ? 2 3.888 ? ? 0 1 0 +26 PF00071.17 16.004 16.004 83.60 +P01112 142 I V ? P01112 142 I V A G benign alignment ? neutral 0 1 1 0.575 NO NO ? -0.196 -1.968 -1.772 2 236 20 20 6q21 142 D 1.00 171 0.173 E B -27 0.04 -1.17 ? ? ? 2 3.888 ? ? 0 0 2 +27 PF00071.17 22.507 22.507 83.60 +P01112 142 I W ? P01112 142 I W ? ? probably damaging alignment ? deleterious 0.999 0.00574 0.136 0.0192 NO NO ? +3.339 -1.968 -5.307 2 236 20 20 6q21 142 D 1.00 171 0.173 E B 60 0.01 -1.17 ? ? ? 2 3.888 ? ? ? ? ? ? PF00071.17 1.194 ? 83.60 +P01112 142 I Y ? P01112 142 I Y ? ? benign alignment ? neutral 0.383 0.106 0.897 0.138 NO NO ? +2.033 -1.968 -4.001 2 236 20 20 6q21 142 D 1.00 171 0.173 E B 26 0.27 -1.17 ? ? ? 2 3.888 ? ? ? ? ? ? PF00071.17 5.960 ? 83.60 +P01112 143 E A ? P01112 143 E A A C probably damaging alignment ? deleterious 0.997 0.0167 0.409 0.0357 NO NO ? +2.195 -1.026 -3.221 2 236 20 20 6q21 143 D 1.00 171 0.257 E B -50 1.04 -0.62 ? ? ? ? ? ? ? 1 1 2 +23 PF00071.17 4.719 ? 82.01 +P01112 143 E C ? P01112 143 E C ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +4.325 -1.026 -5.351 2 236 20 20 6q21 143 D 1.00 171 0.257 E B -30 1.5 -0.62 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 0.707 ? 82.01 +P01112 143 E D ? P01112 143 E D G C benign alignment ? neutral 0.309 0.113 0.904 0.144 NO NO ? +1.246 -1.026 -2.272 2 236 20 20 6q21 143 D 1.00 171 0.257 E B -27 0.29 -0.62 ? ? ? ? ? ? ? 1 2 0 +22 PF00071.17 29.387 29.387 82.01 +P01112 143 E F ? P01112 143 E F ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.387 -1.026 -4.413 2 236 20 20 6q21 143 D 1.00 171 0.257 E B 52 1.62 -0.62 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.338 ? 82.01 +P01112 143 E G ? P01112 143 E G A G probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.425 -1.026 -3.451 2 236 20 20 6q21 143 D 1.00 171 0.257 E B -78 0.75 -0.62 ? ? ? ? ? ? ? 0 1 0 +23 PF00071.17 3.581 ? 82.01 +P01112 143 E H ? P01112 143 E H ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.371 -1.026 -4.397 2 236 20 20 6q21 143 D 1.00 171 0.257 E B 15 0.87 -0.62 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.300 ? 82.01 +P01112 143 E I ? P01112 143 E I ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.105 -1.026 -4.131 2 236 20 20 6q21 143 D 1.00 171 0.257 E B 29 1.52 -0.62 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.208 ? 82.01 +P01112 143 E K ? P01112 143 E K G A probably damaging alignment ? deleterious 0.973 0.044 0.765 0.0723 NO NO ? +1.334 -1.026 -2.360 2 236 20 20 6q21 143 D 1.00 171 0.257 E B 30 1.3 -0.62 ? ? ? ? ? ? ? 0 0 1 +24 PF00071.17 22.723 22.723 82.01 +P01112 143 E L ? P01112 143 E L ? ? probably damaging alignment ? deleterious 0.999 0.00574 0.136 0.0192 NO NO ? +2.644 -1.026 -3.670 2 236 20 20 6q21 143 D 1.00 171 0.257 E B 29 1.59 -0.62 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 3.547 ? 82.01 +P01112 143 E M ? P01112 143 E M ? ? probably damaging alignment ? deleterious 0.999 0.00574 0.136 0.0192 NO NO ? +3.732 -1.026 -4.758 2 236 20 20 6q21 143 D 1.00 171 0.257 E B 25 1.59 -0.62 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.623 ? 82.01 +P01112 143 E N ? P01112 143 E N ? ? probably damaging alignment ? deleterious 0.995 0.0277 0.681 0.0521 NO NO ? +2.515 -1.026 -3.541 2 236 20 20 6q21 143 D 1.00 171 0.257 E B -24 0.43 -0.62 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 5.139 ? 82.01 +P01112 143 E P ? P01112 143 E P ? ? probably damaging alignment ? deleterious 0.999 0.00574 0.136 0.0192 NO NO ? +2.749 -1.026 -3.775 2 236 20 20 6q21 143 D 1.00 171 0.257 E B -26 0.52 -0.62 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.224 ? 82.01 +P01112 143 E Q ? P01112 143 E Q G C probably damaging alignment ? deleterious 0.992 0.0314 0.704 0.0568 NO NO ? +1.474 -1.026 -2.500 2 236 20 20 6q21 143 D 1.00 171 0.257 E B 6 0.4 -0.62 ? ? ? ? ? ? ? 1 0 1 +24 PF00071.17 16.073 16.073 82.01 +P01112 143 E R ? P01112 143 E R ? ? probably damaging alignment ? deleterious 0.999 0.00574 0.136 0.0192 NO NO ? +2.527 -1.026 -3.553 2 236 20 20 6q21 143 D 1.00 171 0.257 E B 35 0.16 -0.62 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 8.791 ? 82.01 +P01112 143 E S ? P01112 143 E S ? ? probably damaging alignment ? deleterious 0.999 0.00574 0.136 0.0192 NO NO ? +2.255 -1.026 -3.281 2 236 20 20 6q21 143 D 1.00 171 0.257 E B -49 0.77 -0.62 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 4.374 ? 82.01 +P01112 143 E T ? P01112 143 E T ? ? probably damaging alignment ? deleterious 0.999 0.00574 0.136 0.0192 NO NO ? +2.516 -1.026 -3.542 2 236 20 20 6q21 143 D 1.00 171 0.257 E B -22 0.82 -0.62 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 3.309 ? 82.01 +P01112 143 E V ? P01112 143 E V A T probably damaging alignment ? deleterious 0.998 0.0112 0.273 0.0274 NO NO ? +2.646 -1.026 -3.672 2 236 20 20 6q21 143 D 1.00 171 0.257 E B 2 1.48 -0.62 ? ? ? ? ? ? ? 1 1 0 +23 PF00071.17 2.730 ? 82.01 +P01112 143 E W ? P01112 143 E W ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +4.411 -1.026 -5.437 2 236 20 20 6q21 143 D 1.00 171 0.257 E B 89 1.51 -0.62 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 0.499 ? 82.01 +P01112 143 E Y ? P01112 143 E Y ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.251 -1.026 -4.277 2 236 20 20 6q21 143 D 1.00 171 0.257 E B 55 1.25 -0.62 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.482 ? 82.01 +P01112 144 T A ? P01112 144 T A A G probably damaging alignment ? deleterious 0.99 0.0338 0.719 0.06 NO NO ? +1.830 -1.125 -2.955 2 236 20 20 6q21 144 D 1.00 171 0.000 E B -28 0.22 -0.54 ? 1 5.852 ? ? ? ? 0 0 0 +21 PF00071.17 8.208 ? 75.66 +P01112 144 T C ? P01112 144 T C ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.680 -1.125 -4.805 2 236 20 20 6q21 144 D 1.00 171 0.000 E B -8 0.68 -0.54 ? 1 5.852 ? ? ? ? ? ? ? ? PF00071.17 1.370 ? 75.66 +P01112 144 T D ? P01112 144 T D ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.423 -1.125 -3.548 2 236 20 20 6q21 144 D 1.00 171 0.000 E B -5 0.53 -0.54 ? 1 5.852 ? ? ? ? ? ? ? ? PF00071.17 3.681 ? 75.66 +P01112 144 T E ? P01112 144 T E ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.356 -1.125 -3.481 2 236 20 20 6q21 144 D 1.00 171 0.000 E B 22 0.82 -0.54 ? 1 5.852 ? ? ? ? ? ? ? ? PF00071.17 7.815 ? 75.66 +P01112 144 T F ? P01112 144 T F ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.039 -1.125 -4.164 2 236 20 20 6q21 144 D 1.00 171 0.000 E B 74 0.8 -0.54 ? 1 5.852 ? ? ? ? ? ? ? ? PF00071.17 2.942 ? 75.66 +P01112 144 T G ? P01112 144 T G ? ? probably damaging alignment ? deleterious 0.996 0.0222 0.545 0.0439 NO NO ? +1.447 -1.125 -2.572 2 236 20 20 6q21 144 D 1.00 171 0.000 E B -56 0.07 -0.54 ? 1 5.852 ? ? ? ? ? ? ? ? PF00071.17 29.944 29.944 75.66 +P01112 144 T H ? P01112 144 T H ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.599 -1.125 -4.724 2 236 20 20 6q21 144 D 1.00 171 0.000 E B 37 0.05 -0.54 ? 1 5.852 ? ? ? ? ? ? ? ? PF00071.17 2.316 ? 75.66 +P01112 144 T I ? P01112 144 T I C T probably damaging alignment ? deleterious 0.998 0.0112 0.273 0.0274 NO NO ? +1.719 -1.125 -2.844 2 236 20 20 6q21 144 D 1.00 171 0.000 E B 51 0.7 -0.54 ? 1 5.852 ? ? ? ? 0 1 0 +20 PF00071.17 17.815 17.815 75.66 +P01112 144 T K ? P01112 144 T K ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.403 -1.125 -3.528 2 236 20 20 6q21 144 D 1.00 171 0.000 E B 52 2.12 -0.54 ? 1 5.852 ? ? ? ? ? ? ? ? PF00071.17 6.839 ? 75.66 +P01112 144 T L ? P01112 144 T L ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.128 -1.125 -3.253 2 236 20 20 6q21 144 D 1.00 171 0.000 E B 51 0.77 -0.54 ? 1 5.852 ? ? ? ? ? ? ? ? PF00071.17 10.996 ? 75.66 +P01112 144 T M ? P01112 144 T M ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.429 -1.125 -4.554 2 236 20 20 6q21 144 D 1.00 171 0.000 E B 47 0.77 -0.54 ? 1 5.852 ? ? ? ? ? ? ? ? PF00071.17 2.423 ? 75.66 +P01112 144 T N ? P01112 144 T N C A probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.432 -1.125 -3.557 2 236 20 20 6q21 144 D 1.00 171 0.000 E B -2 0.39 -0.54 ? 1 5.852 ? ? ? ? 1 1 0 +20 PF00071.17 4.131 ? 75.66 +P01112 144 T P ? P01112 144 T P A C probably damaging alignment ? deleterious 0.997 0.0167 0.409 0.0357 NO NO ? +2.685 -1.125 -3.810 2 236 20 20 6q21 144 D 1.00 171 0.000 E B -4 0.3 -0.54 ? 1 5.852 ? ? ? ? 1 0 0 +21 PF00071.17 2.188 ? 75.66 +P01112 144 T Q ? P01112 144 T Q ? ? probably damaging alignment ? deleterious 0.999 0.00574 0.136 0.0192 NO NO ? +1.809 -1.125 -2.934 2 236 20 20 6q21 144 D 1.00 171 0.000 E B 28 0.42 -0.54 ? 1 5.852 ? ? ? ? ? ? ? ? PF00071.17 16.186 16.186 75.66 +P01112 144 T R ? P01112 144 T R ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.692 -1.125 -3.817 2 236 20 20 6q21 144 D 1.00 171 0.000 E B 57 0.98 -0.54 ? 1 5.852 ? ? ? ? ? ? ? ? PF00071.17 5.490 ? 75.66 +P01112 144 T S ? P01112 144 T S C G possibly damaging alignment ? deleterious 0.76 0.0769 0.852 0.109 NO NO ? +1.051 -1.125 -2.176 2 236 20 20 6q21 144 D 1.00 171 0.000 E B -27 0.05 -0.54 ? 1 5.852 ? ? ? ? 1 1 0 +20 PF00071.17 16.523 16.523 75.66 +P01112 144 T V ? P01112 144 T V ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.113 -1.125 -3.238 2 236 20 20 6q21 144 D 1.00 171 0.000 E B 24 0.66 -0.54 ? 1 5.852 ? ? ? ? ? ? ? ? PF00071.17 11.566 ? 75.66 +P01112 144 T W ? P01112 144 T W ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +4.131 -1.125 -5.256 2 236 20 20 6q21 144 D 1.00 171 0.000 E B 111 0.69 -0.54 ? 1 5.852 ? ? ? ? ? ? ? ? PF00071.17 0.502 ? 75.66 +P01112 144 T Y ? P01112 144 T Y ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.124 -1.125 -4.249 2 236 20 20 6q21 144 D 1.00 171 0.000 E B 77 0.43 -0.54 ? 1 5.852 ? ? ? ? ? ? ? ? PF00071.17 1.493 ? 75.66 +P01112 145 S A ? P01112 145 S A T G possibly damaging alignment ? deleterious 0.922 0.0588 0.809 0.0896 NO NO ? +1.321 -0.870 -2.191 2 236 20 20 6q21 145 D 1.00 171 0.000 . b -1 0.27 -0.50 ? 1 3.496 ? ? ? ? 1 0 2 +18 PF00071.17 21.763 21.763 75.13 +P01112 145 S C ? P01112 145 S C ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.794 -0.870 -4.664 2 236 20 20 6q21 145 D 1.00 171 0.000 . b 19 0.73 -0.50 ? 1 3.496 ? ? ? ? ? ? ? ? PF00071.17 1.610 ? 75.13 +P01112 145 S D ? P01112 145 S D ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.463 -0.870 -3.333 2 236 20 20 6q21 145 D 1.00 171 0.000 . b 22 0.48 -0.50 ? 1 3.496 ? ? ? ? ? ? ? ? PF00071.17 2.194 ? 75.13 +P01112 145 S E ? P01112 145 S E ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.417 -0.870 -3.287 2 236 20 20 6q21 145 D 1.00 171 0.000 . b 49 0.77 -0.50 ? 1 3.496 ? ? ? ? ? ? ? ? PF00071.17 3.025 ? 75.13 +P01112 145 S F ? P01112 145 S F ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.249 -0.870 -4.119 2 236 20 20 6q21 145 D 1.00 171 0.000 . b 101 0.85 -0.50 ? 1 3.496 ? ? ? ? ? ? ? ? PF00071.17 1.656 ? 75.13 +P01112 145 S G ? P01112 145 S G ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.090 -0.870 -2.960 2 236 20 20 6q21 145 D 1.00 171 0.000 . b -29 0.02 -0.50 ? 1 3.496 ? ? ? ? ? ? ? ? PF00071.17 5.888 ? 75.13 +P01112 145 S H ? P01112 145 S H ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.657 -0.870 -4.527 2 236 20 20 6q21 145 D 1.00 171 0.000 . b 64 0.1 -0.50 ? 1 3.496 ? ? ? ? ? ? ? ? PF00071.17 1.121 ? 75.13 +P01112 145 S I ? P01112 145 S I ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.942 -0.870 -3.812 2 236 20 20 6q21 145 D 1.00 171 0.000 . b 78 0.75 -0.50 ? 1 3.496 ? ? ? ? ? ? ? ? PF00071.17 3.227 ? 75.13 +P01112 145 S K ? P01112 145 S K ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.434 -0.870 -3.304 2 236 20 20 6q21 145 D 1.00 171 0.000 . b 79 2.07 -0.50 ? 1 3.496 ? ? ? ? ? ? ? ? PF00071.17 3.388 ? 75.13 +P01112 145 S L ? P01112 145 S L C T probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.515 -0.870 -3.385 2 236 20 20 6q21 145 D 1.00 171 0.000 . b 78 0.82 -0.50 ? 1 3.496 ? ? ? ? 0 1 1 +17 PF00071.17 4.473 ? 75.13 +P01112 145 S M ? P01112 145 S M ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.661 -0.870 -4.531 2 236 20 20 6q21 145 D 1.00 171 0.000 . b 74 0.82 -0.50 ? 1 3.496 ? ? ? ? ? ? ? ? PF00071.17 1.358 ? 75.13 +P01112 145 S N ? P01112 145 S N ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.455 -0.870 -3.325 2 236 20 20 6q21 145 D 1.00 171 0.000 . b 25 0.34 -0.50 ? 1 3.496 ? ? ? ? ? ? ? ? PF00071.17 1.973 ? 75.13 +P01112 145 S P ? P01112 145 S P T C probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.836 -0.870 -3.706 2 236 20 20 6q21 145 D 1.00 171 0.000 . b 23 0.25 -0.50 ? 1 3.496 ? ? ? ? 0 0 0 +18 PF00071.17 2.184 ? 75.13 +P01112 145 S Q ? P01112 145 S Q ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.876 -0.870 -3.746 2 236 20 20 6q21 145 D 1.00 171 0.000 . b 55 0.37 -0.50 ? 1 3.496 ? ? ? ? ? ? ? ? PF00071.17 1.948 ? 75.13 +P01112 145 S R ? P01112 145 S R ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.890 -0.870 -3.760 2 236 20 20 6q21 145 D 1.00 171 0.000 . b 84 0.93 -0.50 ? 1 3.496 ? ? ? ? ? ? ? ? PF00071.17 2.376 ? 75.13 +P01112 145 S T ? P01112 145 S T T A probably damaging alignment ? deleterious 0.997 0.0167 0.409 0.0357 NO NO ? +2.173 -0.870 -3.043 2 236 20 20 6q21 145 D 1.00 171 0.000 . b 27 0.05 -0.50 ? 1 3.496 ? ? ? ? 1 0 0 +18 PF00071.17 3.764 ? 75.13 +P01112 145 S V ? P01112 145 S V ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.654 -0.870 -3.524 2 236 20 20 6q21 145 D 1.00 171 0.000 . b 51 0.71 -0.50 ? 1 3.496 ? ? ? ? ? ? ? ? PF00071.17 5.130 ? 75.13 +P01112 145 S W ? P01112 145 S W C G probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +4.504 -0.870 -5.374 2 236 20 20 6q21 145 D 1.00 171 0.000 . b 138 0.74 -0.50 ? 1 3.496 ? ? ? ? 1 1 1 +17 PF00071.17 0.408 ? 75.13 +P01112 145 S Y ? P01112 145 S Y ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.344 -0.870 -4.214 2 236 20 20 6q21 145 D 1.00 171 0.000 . b 104 0.48 -0.50 ? 1 3.496 ? ? ? ? ? ? ? ? PF00071.17 1.316 ? 75.13 +P01112 146 A C ? P01112 146 A C ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.664 -0.859 -4.523 2 235 20 20 6q21 146 D 1.00 171 0.029 S A 20 0.46 -0.16 ? 1 4.055 ? ? ? ? ? ? ? ? PF00071.17 1.441 ? 78.84 +P01112 146 A D ? P01112 146 A D C A probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.903 -0.859 -3.762 2 235 20 20 6q21 146 D 1.00 171 0.029 S A 23 0.75 -0.16 ? 1 4.055 ? ? ? ? 1 1 0 +14 PF00071.17 2.937 ? 78.84 +P01112 146 A E ? P01112 146 A E ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.673 -0.859 -3.532 2 235 20 20 6q21 146 D 1.00 171 0.029 S A 50 1.04 -0.16 ? 1 4.055 ? ? ? ? ? ? ? ? PF00071.17 3.175 ? 78.84 +P01112 146 A F ? P01112 146 A F ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.258 -0.859 -4.117 2 235 20 20 6q21 146 D 1.00 171 0.029 S A 102 0.58 -0.16 ? 1 4.055 ? ? ? ? ? ? ? ? PF00071.17 2.654 ? 78.84 +P01112 146 A G ? P01112 146 A G C G probably damaging alignment ? deleterious 0.995 0.0277 0.681 0.0521 NO NO ? +2.204 -0.859 -3.063 2 235 20 20 6q21 146 D 1.00 171 0.029 S A -28 0.29 -0.16 ? 1 4.055 ? ? ? ? 1 1 0 +14 PF00071.17 3.386 ? 78.84 +P01112 146 A H ? P01112 146 A H ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.913 -0.859 -4.772 2 235 20 20 6q21 146 D 1.00 171 0.029 S A 65 0.17 -0.16 ? 1 4.055 ? ? ? ? ? ? ? ? PF00071.17 1.152 ? 78.84 +P01112 146 A I ? P01112 146 A I ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.649 -0.859 -3.508 2 235 20 20 6q21 146 D 1.00 171 0.029 S A 79 0.48 -0.16 ? 1 4.055 ? ? ? ? ? ? ? ? PF00071.17 12.336 ? 78.84 +P01112 146 A K ? P01112 146 A K ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.690 -0.859 -3.549 2 235 20 20 6q21 146 D 1.00 171 0.029 S A 80 2.34 -0.16 ? 1 4.055 ? ? ? ? ? ? ? ? PF00071.17 3.635 ? 78.84 +P01112 146 A L ? P01112 146 A L ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.296 -0.859 -3.155 2 235 20 20 6q21 146 D 1.00 171 0.029 S A 79 0.55 -0.16 ? 1 4.055 ? ? ? ? ? ? ? ? PF00071.17 9.766 ? 78.84 +P01112 146 A M ? P01112 146 A M ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.643 -0.859 -4.502 2 235 20 20 6q21 146 D 1.00 171 0.029 S A 75 0.55 -0.16 ? 1 4.055 ? ? ? ? ? ? ? ? PF00071.17 2.383 ? 78.84 +P01112 146 A N ? P01112 146 A N ? ? probably damaging alignment ? deleterious 0.999 0.00574 0.136 0.0192 NO NO ? +3.079 -0.859 -3.938 2 235 20 20 6q21 146 D 1.00 171 0.029 S A 26 0.61 -0.16 ? 1 4.055 ? ? ? ? ? ? ? ? PF00071.17 3.464 ? 78.84 +P01112 146 A P ? P01112 146 A P G C probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.887 -0.859 -3.746 2 235 20 20 6q21 146 D 1.00 171 0.029 S A 24 0.52 -0.16 ? 1 4.055 ? ? ? ? 1 0 0 +15 PF00071.17 2.093 ? 78.84 +P01112 146 A Q ? P01112 146 A Q ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.132 -0.859 -3.991 2 235 20 20 6q21 146 D 1.00 171 0.029 S A 56 0.64 -0.16 ? 1 4.055 ? ? ? ? ? ? ? ? PF00071.17 2.137 ? 78.84 +P01112 146 A R ? P01112 146 A R ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.956 -0.859 -3.815 2 235 20 20 6q21 146 D 1.00 171 0.029 S A 85 1.2 -0.16 ? 1 4.055 ? ? ? ? ? ? ? ? PF00071.17 2.758 ? 78.84 +P01112 146 A S ? P01112 146 A S G T probably damaging alignment ? deleterious 0.986 0.0368 0.736 0.0634 NO NO ? +2.196 -0.859 -3.055 2 235 20 20 6q21 146 D 1.00 171 0.029 S A 1 0.27 -0.16 ? 1 4.055 ? ? ? ? 1 0 0 +15 PF00071.17 7.282 ? 78.84 +P01112 146 A T ? P01112 146 A T G A possibly damaging alignment ? deleterious 0.935 0.057 0.803 0.0878 NO NO ? +1.671 -0.859 -2.530 2 235 20 20 6q21 146 D 1.00 171 0.029 S A 28 0.22 -0.16 ? 1 4.055 ? ? ? ? 0 0 0 +15 PF00071.17 19.387 19.387 78.84 +P01112 146 A V ? P01112 146 A V C T probably damaging alignment ? deleterious 0.988 0.0353 0.727 0.0617 NO NO ? +1.631 -0.859 -2.490 2 235 20 20 6q21 146 D 1.00 171 0.029 S A 52 0.44 -0.16 ? 1 4.055 ? ? ? ? 0 1 0 +14 PF00071.17 20.228 20.228 78.84 +P01112 146 A W ? P01112 146 A W ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +4.514 -0.859 -5.373 2 235 20 20 6q21 146 D 1.00 171 0.029 S A 139 0.47 -0.16 ? 1 4.055 ? ? ? ? ? ? ? ? PF00071.17 0.443 ? 78.84 +P01112 146 A Y ? P01112 146 A Y ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.354 -0.859 -4.213 2 235 20 20 6q21 146 D 1.00 171 0.029 S A 105 0.21 -0.16 ? 1 4.055 ? ? ? ? ? ? ? ? PF00071.17 1.596 ? 78.84 +P01112 147 K A ? P01112 147 K A ? ? probably damaging alignment ? deleterious 0.997 0.0167 0.409 0.0357 NO NO ? +2.163 -0.966 -3.129 2 235 20 20 6q21 147 D 1.00 171 0.614 S A -80 2.34 0.28 ? 1 3.510 ? ? ? ? ? ? ? ? PF00071.17 5.258 ? 75.66 +P01112 147 K C ? P01112 147 K C ? ? probably damaging alignment ? deleterious 0.962 0.0478 0.779 0.0767 NO NO ? +2.135 -0.966 -3.101 2 235 20 20 6q21 147 D 1.00 171 0.614 S A -60 2.8 0.28 ? 1 3.510 ? ? ? ? ? ? ? ? PF00071.17 36.311 36.311 75.66 +P01112 147 K D ? P01112 147 K D ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.677 -0.966 -3.643 2 235 20 20 6q21 147 D 1.00 171 0.614 S A -57 1.59 0.28 ? 1 3.510 ? ? ? ? ? ? ? ? PF00071.17 1.496 ? 75.66 +P01112 147 K E ? P01112 147 K E A G probably damaging alignment ? deleterious 0.997 0.0167 0.409 0.0357 NO NO ? +2.239 -0.966 -3.205 2 235 20 20 6q21 147 D 1.00 171 0.614 S A -30 1.3 0.28 ? 1 3.510 ? ? ? ? 0 0 2 +12 PF00071.17 2.540 ? 75.66 +P01112 147 K F ? P01112 147 K F ? ? probably damaging alignment ? deleterious 0.999 0.00574 0.136 0.0192 NO NO ? +3.352 -0.966 -4.318 2 235 20 20 6q21 147 D 1.00 171 0.614 S A 22 2.92 0.28 ? 1 3.510 ? ? ? ? ? ? ? ? PF00071.17 2.673 ? 75.66 +P01112 147 K G ? P01112 147 K G ? ? probably damaging alignment ? deleterious 0.999 0.00574 0.136 0.0192 NO NO ? +2.520 -0.966 -3.486 2 235 20 20 6q21 147 D 1.00 171 0.614 S A -108 2.05 0.28 ? 1 3.510 ? ? ? ? ? ? ? ? PF00071.17 2.342 ? 75.66 +P01112 147 K H ? P01112 147 K H ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.623 -0.966 -4.589 2 235 20 20 6q21 147 D 1.00 171 0.614 S A -15 2.17 0.28 ? 1 3.510 ? ? ? ? ? ? ? ? PF00071.17 1.170 ? 75.66 +P01112 147 K I ? P01112 147 K I ? ? probably damaging alignment ? deleterious 0.972 0.0442 0.766 0.0725 NO NO ? +2.884 -0.966 -3.850 2 235 20 20 6q21 147 D 1.00 171 0.614 S A -1 2.82 0.28 ? 1 3.510 ? ? ? ? ? ? ? ? PF00071.17 12.423 ? 75.66 +P01112 147 K L ? P01112 147 K L ? ? possibly damaging alignment ? deleterious 0.904 0.0621 0.816 0.0934 NO NO ? +2.388 -0.966 -3.354 2 235 20 20 6q21 147 D 1.00 171 0.614 S A -1 2.89 0.28 ? 1 3.510 ? ? ? ? ? ? ? ? PF00071.17 9.835 ? 75.66 +P01112 147 K M ? P01112 147 K M A T probably damaging alignment ? deleterious 0.998 0.0112 0.273 0.0274 NO NO ? +3.560 -0.966 -4.526 2 235 20 20 6q21 147 D 1.00 171 0.614 S A -5 2.89 0.28 ? 1 3.510 ? ? ? ? 1 1 0 +11 PF00071.17 2.399 ? 75.66 +P01112 147 K N ? P01112 147 K N G C probably damaging alignment ? deleterious 0.999 0.00574 0.136 0.0192 NO NO ? +2.661 -0.966 -3.627 2 235 20 20 6q21 147 D 1.00 171 0.614 S A -54 1.73 0.28 ? 1 3.510 ? ? ? ? 1 2 0 +10 PF00071.17 1.866 ? 75.66 +P01112 147 K P ? P01112 147 K P ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.848 -0.966 -3.814 2 235 20 20 6q21 147 D 1.00 171 0.614 S A -56 1.82 0.28 ? 1 3.510 ? ? ? ? ? ? ? ? PF00071.17 1.292 ? 75.66 +P01112 147 K Q ? P01112 147 K Q A C probably damaging alignment ? deleterious 0.992 0.0314 0.704 0.0568 NO NO ? +2.672 -0.966 -3.638 2 235 20 20 6q21 147 D 1.00 171 0.614 S A -24 1.7 0.28 ? 1 3.510 ? ? ? ? 1 0 0 +12 PF00071.17 2.344 ? 75.66 +P01112 147 K R ? P01112 147 K R A G possibly damaging alignment ? deleterious 0.813 0.0709 0.84 0.103 NO NO ? +1.624 -0.966 -2.590 2 235 20 20 6q21 147 D 1.00 171 0.614 S A 5 1.14 0.28 ? 1 3.510 ? ? ? ? 0 1 0 +11 PF00071.17 16.747 16.747 75.66 +P01112 147 K S ? P01112 147 K S ? ? probably damaging alignment ? deleterious 0.998 0.0112 0.273 0.0274 NO NO ? +2.354 -0.966 -3.320 2 235 20 20 6q21 147 D 1.00 171 0.614 S A -79 2.07 0.28 ? 1 3.510 ? ? ? ? ? ? ? ? PF00071.17 3.175 ? 75.66 +P01112 147 K T ? P01112 147 K T A C probably damaging alignment ? deleterious 0.993 0.0301 0.696 0.0553 NO NO ? +2.527 -0.966 -3.493 2 235 20 20 6q21 147 D 1.00 171 0.614 S A -52 2.12 0.28 ? 1 3.510 ? ? ? ? 1 1 2 +11 PF00071.17 3.777 ? 75.66 +P01112 147 K V ? P01112 147 K V ? ? benign alignment ? neutral 0.22 0.122 0.914 0.153 NO NO ? +1.755 -0.966 -2.721 2 235 20 20 6q21 147 D 1.00 171 0.614 S A -28 2.78 0.28 ? 1 3.510 ? ? ? ? ? ? ? ? PF00071.17 20.370 20.370 75.66 +P01112 147 K W ? P01112 147 K W ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +4.428 -0.966 -5.394 2 235 20 20 6q21 147 D 1.00 171 0.614 S A 59 2.81 0.28 ? 1 3.510 ? ? ? ? ? ? ? ? PF00071.17 0.441 ? 75.66 +P01112 147 K Y ? P01112 147 K Y ? ? probably damaging alignment ? deleterious 0.996 0.0222 0.545 0.0439 NO NO ? +3.268 -0.966 -4.234 2 235 20 20 6q21 147 D 1.00 171 0.614 S A 25 2.55 0.28 ? 1 3.510 ? ? ? ? ? ? ? ? PF00071.17 1.607 ? 75.66 +P01112 148 T A ? P01112 148 T A A G benign alignment ? neutral 0.003 0.556 0.981 0.39 NO NO ? +0.962 -1.553 -2.515 2 235 20 20 6q21 148 D 1.00 171 0.417 S A -28 0.22 0.13 ? ? ? ? ? ? ? 0 0 0 +9 PF00071.17 19.924 19.924 75.66 +P01112 148 T C ? P01112 148 T C ? ? benign alignment ? neutral 0.432 0.102 0.892 0.134 NO NO ? +1.871 -1.553 -3.424 2 235 20 20 6q21 148 D 1.00 171 0.417 S A -8 0.68 0.13 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 36.567 36.567 75.66 +P01112 148 T D ? P01112 148 T D ? ? benign alignment ? neutral 0.059 0.162 0.938 0.189 NO NO ? +1.387 -1.553 -2.940 2 235 20 20 6q21 148 D 1.00 171 0.417 S A -5 0.53 0.13 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 20.781 20.781 75.66 +P01112 148 T E ? P01112 148 T E ? ? benign alignment ? neutral 0.269 0.116 0.909 0.148 NO NO ? +1.345 -1.553 -2.898 2 235 20 20 6q21 148 D 1.00 171 0.417 S A 22 0.82 0.13 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 16.032 16.032 75.66 +P01112 148 T F ? P01112 148 T F ? ? benign alignment ? neutral 0.438 0.101 0.891 0.133 NO NO ? +1.689 -1.553 -3.242 2 235 20 20 6q21 148 D 1.00 171 0.417 S A 74 0.8 0.13 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 28.960 28.960 75.66 +P01112 148 T G ? P01112 148 T G ? ? probably damaging alignment ? deleterious 0.958 0.0492 0.783 0.0785 NO NO ? +1.935 -1.553 -3.488 2 235 20 20 6q21 148 D 1.00 171 0.417 S A -56 0.07 0.13 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 5.390 ? 75.66 +P01112 148 T H ? P01112 148 T H ? ? probably damaging alignment ? deleterious 0.995 0.0277 0.681 0.0521 NO NO ? +3.176 -1.553 -4.729 2 235 20 20 6q21 148 D 1.00 171 0.417 S A 37 0.05 0.13 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.685 ? 75.66 +P01112 148 T I ? P01112 148 T I C T possibly damaging alignment ? neutral 0.485 0.098 0.885 0.13 NO NO ? +1.557 -1.553 -3.110 2 235 20 20 6q21 148 D 1.00 171 0.417 S A 51 0.7 0.13 ? ? ? ? ? ? ? 0 1 0 +8 PF00071.17 18.102 18.102 75.66 +P01112 148 T K ? P01112 148 T K ? ? benign alignment ? neutral 0.34 0.11 0.9 0.142 NO NO ? +1.149 -1.553 -2.702 2 235 20 20 6q21 148 D 1.00 171 0.417 S A 52 2.12 0.13 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 17.885 17.885 75.66 +P01112 148 T L ? P01112 148 T L ? ? possibly damaging alignment ? deleterious 0.927 0.0581 0.807 0.0889 NO NO ? +1.865 -1.553 -3.418 2 235 20 20 6q21 148 D 1.00 171 0.417 S A 51 0.77 0.13 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 11.173 ? 75.66 +P01112 148 T M ? P01112 148 T M ? ? probably damaging alignment ? deleterious 0.995 0.0277 0.681 0.0521 NO NO ? +3.136 -1.553 -4.689 2 235 20 20 6q21 148 D 1.00 171 0.417 S A 47 0.77 0.13 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.462 ? 75.66 +P01112 148 T N ? P01112 148 T N C A benign alignment ? neutral 0.168 0.131 0.919 0.162 NO NO ? +1.443 -1.553 -2.996 2 235 20 20 6q21 148 D 1.00 171 0.417 S A -2 0.39 0.13 ? ? ? ? ? ? ? 1 1 0 +8 PF00071.17 14.077 14.077 75.66 +P01112 148 T P ? P01112 148 T P A C possibly damaging alignment ? deleterious 0.893 0.0634 0.821 0.0948 NO NO ? +2.414 -1.553 -3.967 2 235 20 20 6q21 148 D 1.00 171 0.417 S A -4 0.3 0.13 ? ? ? ? ? ? ? 1 0 0 +9 PF00071.17 1.999 ? 75.66 +P01112 148 T Q ? P01112 148 T Q ? ? possibly damaging alignment ? deleterious 0.629 0.0892 0.868 0.122 NO NO ? +1.592 -1.553 -3.145 2 235 20 20 6q21 148 D 1.00 171 0.417 S A 28 0.42 0.13 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 11.772 11.772 75.66 +P01112 148 T R ? P01112 148 T R ? ? possibly damaging alignment ? deleterious 0.579 0.0935 0.875 0.126 NO NO ? +1.282 -1.553 -2.835 2 235 20 20 6q21 148 D 1.00 171 0.417 S A 57 0.98 0.13 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 16.929 16.929 75.66 +P01112 148 T S ? P01112 148 T S C G benign alignment ? neutral 0.012 0.219 0.958 0.236 NO NO ? +0.903 -1.553 -2.456 2 235 20 20 6q21 148 D 1.00 171 0.417 S A -27 0.05 0.13 ? ? ? ? ? ? ? 1 1 0 +8 PF00071.17 14.661 14.661 75.66 +P01112 148 T V ? P01112 148 T V ? ? possibly damaging alignment ? deleterious 0.901 0.0625 0.818 0.0939 NO NO ? +1.917 -1.553 -3.470 2 235 20 20 6q21 148 D 1.00 171 0.417 S A 24 0.66 0.13 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 11.752 ? 75.66 +P01112 148 T W ? P01112 148 T W ? ? probably damaging alignment ? deleterious 0.999 0.00574 0.136 0.0192 NO NO ? +3.843 -1.553 -5.396 2 235 20 20 6q21 148 D 1.00 171 0.417 S A 111 0.69 0.13 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.345 ? 75.66 +P01112 148 T Y ? P01112 148 T Y ? ? probably damaging alignment ? deleterious 0.971 0.0444 0.768 0.0727 NO NO ? +2.724 -1.553 -4.277 2 235 20 20 6q21 148 D 1.00 171 0.417 S A 77 0.43 0.13 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 6.717 ? 75.66 +P01112 149 R A ? P01112 149 R A ? ? probably damaging alignment ? deleterious 0.977 0.0424 0.758 0.0704 NO NO ? +1.785 -1.373 -3.158 2 235 20 20 6q21 149 D 1.00 171 0.226 . l -85 1.2 0.16 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 3.860 ? 75.66 +P01112 149 R C ? P01112 149 R C ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.791 -1.373 -5.164 2 235 20 20 6q21 149 D 1.00 171 0.226 . l -65 1.66 0.16 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.200 ? 75.66 +P01112 149 R D ? P01112 149 R D ? ? probably damaging alignment ? deleterious 0.993 0.0301 0.696 0.0553 NO NO ? +2.302 -1.373 -3.675 2 235 20 20 6q21 149 D 1.00 171 0.226 . l -62 0.45 0.16 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 4.166 ? 75.66 +P01112 149 R E ? P01112 149 R E ? ? possibly damaging alignment ? neutral 0.478 0.0986 0.886 0.131 NO NO ? +1.346 -1.373 -2.719 2 235 20 20 6q21 149 D 1.00 171 0.226 . l -35 0.16 0.16 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 13.674 13.674 75.66 +P01112 149 R F ? P01112 149 R F ? ? probably damaging alignment ? deleterious 0.996 0.0222 0.545 0.0439 NO NO ? +2.978 -1.373 -4.351 2 235 20 20 6q21 149 D 1.00 171 0.226 . l 17 1.78 0.16 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 4.142 ? 75.66 +P01112 149 R G ? P01112 149 R G C G benign alignment ? neutral 0.205 0.124 0.915 0.155 NO NO ? +0.687 -1.373 -2.060 2 235 20 20 6q21 149 D 1.00 171 0.226 . l -113 0.91 0.16 ? ? ? ? ? ? ? 1 0 3 +6 PF00071.17 25.088 25.088 75.66 +P01112 149 R H ? P01112 149 R H ? ? probably damaging alignment ? deleterious 0.999 0.00574 0.136 0.0192 NO NO ? +3.158 -1.373 -4.531 2 235 20 20 6q21 149 D 1.00 171 0.226 . l -20 1.03 0.16 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.275 ? 75.66 +P01112 149 R I ? P01112 149 R I ? ? probably damaging alignment ? deleterious 0.969 0.045 0.77 0.0734 NO NO ? +2.639 -1.373 -4.012 2 235 20 20 6q21 149 D 1.00 171 0.226 . l -6 1.68 0.16 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 8.707 ? 75.66 +P01112 149 R K ? P01112 149 R K ? ? benign alignment ? neutral 0.137 0.137 0.924 0.168 NO NO ? +0.853 -1.373 -2.226 2 235 20 20 6q21 149 D 1.00 171 0.226 . l -5 1.14 0.16 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 17.299 17.299 75.66 +P01112 149 R L ? P01112 149 R L G T possibly damaging alignment ? deleterious 0.579 0.0935 0.875 0.126 NO NO ? +1.390 -1.373 -2.763 2 235 20 20 6q21 149 D 1.00 171 0.226 . l -6 1.75 0.16 ? ? ? ? ? ? ? 1 1 1 +5 PF00071.17 28.412 28.412 75.66 +P01112 149 R M ? P01112 149 R M ? ? probably damaging alignment ? deleterious 0.996 0.0222 0.545 0.0439 NO NO ? +3.256 -1.373 -4.629 2 235 20 20 6q21 149 D 1.00 171 0.226 . l -10 1.75 0.16 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 3.771 ? 75.66 +P01112 149 R N ? P01112 149 R N ? ? probably damaging alignment ? deleterious 0.997 0.0167 0.409 0.0357 NO NO ? +2.248 -1.373 -3.621 2 235 20 20 6q21 149 D 1.00 171 0.226 . l -59 0.59 0.16 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.620 ? 75.66 +P01112 149 R P ? P01112 149 R P G C probably damaging alignment ? deleterious 0.998 0.0112 0.273 0.0274 NO NO ? +2.592 -1.373 -3.965 2 235 20 20 6q21 149 D 1.00 171 0.226 . l -61 0.68 0.16 ? ? ? ? ? ? ? 1 1 3 +5 PF00071.17 1.693 ? 75.66 +P01112 149 R Q ? P01112 149 R Q G A probably damaging alignment ? deleterious 0.998 0.0112 0.273 0.0274 NO NO ? +2.350 -1.373 -3.723 2 235 20 20 6q21 149 D 1.00 171 0.226 . l -29 0.56 0.16 ? ? ? ? ? ? ? 0 1 1 +5 PF00071.17 3.325 ? 75.66 +P01112 149 R S ? P01112 149 R S ? ? probably damaging alignment ? deleterious 0.993 0.0301 0.696 0.0553 NO NO ? +2.038 -1.373 -3.411 2 235 20 20 6q21 149 D 1.00 171 0.226 . l -84 0.93 0.16 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 3.812 ? 75.66 +P01112 149 R T ? P01112 149 R T ? ? possibly damaging alignment ? deleterious 0.956 0.0501 0.785 0.0796 NO NO ? +1.413 -1.373 -2.786 2 235 20 20 6q21 149 D 1.00 171 0.226 . l -57 0.98 0.16 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 10.149 10.149 75.66 +P01112 149 R V ? P01112 149 R V ? ? probably damaging alignment ? deleterious 0.958 0.0492 0.783 0.0785 NO NO ? +2.321 -1.373 -3.694 2 235 20 20 6q21 149 D 1.00 171 0.226 . l -33 1.64 0.16 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 7.251 ? 75.66 +P01112 149 R W ? P01112 149 R W C T probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +4.013 -1.373 -5.386 2 235 20 20 6q21 149 D 1.00 171 0.226 . l 54 1.67 0.16 ? ? ? ? ? ? ? 0 0 1 +6 PF00071.17 0.560 ? 75.66 +P01112 149 R Y ? P01112 149 R Y ? ? probably damaging alignment ? deleterious 0.998 0.0112 0.273 0.0274 NO NO ? +2.946 -1.373 -4.319 2 235 20 20 6q21 149 D 1.00 171 0.226 . l 20 1.41 0.16 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.690 ? 75.66 +P01112 150 Q A ? P01112 150 Q A ? ? benign alignment ? neutral 0.294 0.114 0.906 0.146 NO NO ? +1.386 -1.883 -3.269 2 235 20 20 6q21 150 D 1.00 171 0.641 T B -56 0.64 0.10 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 5.376 ? 79.89 +P01112 150 Q C ? P01112 150 Q C ? ? possibly damaging alignment ? deleterious 0.953 0.0514 0.788 0.0812 NO NO ? +3.210 -1.883 -5.093 2 235 20 20 6q21 150 D 1.00 171 0.641 T B -36 1.1 0.10 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.333 ? 79.89 +P01112 150 Q D ? P01112 150 Q D ? ? possibly damaging alignment ? neutral 0.467 0.0992 0.887 0.132 NO NO ? +1.879 -1.883 -3.762 2 235 20 20 6q21 150 D 1.00 171 0.641 T B -33 0.11 0.10 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 3.975 ? 79.89 +P01112 150 Q E ? P01112 150 Q E C G benign alignment ? neutral 0.051 0.165 0.941 0.192 NO NO ? +1.022 -1.883 -2.905 2 235 20 20 6q21 150 D 1.00 171 0.641 T B -6 0.4 0.10 ? ? ? ? ? ? ? 1 0 0 +3 PF00071.17 13.046 13.046 79.89 +P01112 150 Q F ? P01112 150 Q F ? ? possibly damaging alignment ? deleterious 0.619 0.0903 0.87 0.123 NO NO ? +2.335 -1.883 -4.218 2 235 20 20 6q21 150 D 1.00 171 0.641 T B 46 1.22 0.10 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 4.374 ? 79.89 +P01112 150 Q G ? P01112 150 Q G ? ? possibly damaging alignment ? neutral 0.454 0.0996 0.889 0.132 NO NO ? +1.809 -1.883 -3.692 2 235 20 20 6q21 150 D 1.00 171 0.641 T B -84 0.35 0.10 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 3.297 ? 79.89 +P01112 150 Q H ? P01112 150 Q H G C benign alignment ? neutral 0.01 0.226 0.96 0.242 NO NO ? +1.542 -1.883 -3.425 2 235 20 20 6q21 150 D 1.00 171 0.641 T B 9 0.47 0.10 ? ? ? ? ? ? ? 1 2 2 +1 PF00071.17 20.043 20.043 79.89 +P01112 150 Q I ? P01112 150 Q I ? ? benign alignment ? neutral 0.01 0.226 0.96 0.242 NO NO ? +0.761 -1.883 -2.644 2 235 20 20 6q21 150 D 1.00 171 0.641 T B 23 1.12 0.10 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 18.102 18.102 79.89 +P01112 150 Q K ? P01112 150 Q K C A benign alignment ? neutral 0.004 0.408 0.975 0.328 NO NO ? +1.047 -1.883 -2.930 2 235 20 20 6q21 150 D 1.00 171 0.641 T B 24 1.7 0.10 ? ? ? ? ? ? ? 1 0 0 +3 PF00071.17 19.644 19.644 79.89 +P01112 150 Q L ? P01112 150 Q L A T benign alignment ? neutral 0.001 0.852 0.994 0.514 NO NO ? +0.437 -1.883 -2.320 2 235 20 20 6q21 150 D 1.00 171 0.641 T B 23 1.19 0.10 ? ? ? ? ? ? ? 1 1 0 +2 PF00071.17 30.002 30.002 79.89 +P01112 150 Q M ? P01112 150 Q M ? ? benign alignment ? neutral 0.064 0.159 0.937 0.187 NO NO ? +1.002 -1.883 -2.885 2 235 20 20 6q21 150 D 1.00 171 0.641 T B 19 1.19 0.10 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 12.769 12.769 79.89 +P01112 150 Q N ? P01112 150 Q N ? ? possibly damaging alignment ? neutral 0.467 0.0992 0.887 0.132 NO NO ? +1.996 -1.883 -3.879 2 235 20 20 6q21 150 D 1.00 171 0.641 T B -30 0.0299999999999999 0.10 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 3.115 ? 79.89 +P01112 150 Q P ? P01112 150 Q P A C benign alignment ? neutral 0.003 0.556 0.981 0.39 NO NO ? +1.254 -1.883 -3.137 2 235 20 20 6q21 150 D 1.00 171 0.641 T B -32 0.12 0.10 ? ? ? ? ? ? ? 1 1 2 +2 PF00071.17 24.606 24.606 79.89 +P01112 150 Q R ? P01112 150 Q R A G benign alignment ? neutral 0.001 0.852 0.994 0.514 NO NO ? +0.982 -1.883 -2.865 2 235 20 20 6q21 150 D 1.00 171 0.641 T B 29 0.56 0.10 ? ? ? ? ? ? ? 0 1 2 +2 PF00071.17 22.390 22.390 79.89 +P01112 150 Q S ? P01112 150 Q S ? ? benign alignment ? neutral 0.147 0.135 0.922 0.165 NO NO ? +1.074 -1.883 -2.957 2 235 20 20 6q21 150 D 1.00 171 0.641 T B -55 0.37 0.10 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 10.822 10.822 79.89 +P01112 150 Q T ? P01112 150 Q T ? ? benign alignment ? neutral 0.001 0.852 0.994 0.514 NO NO ? +0.876 -1.883 -2.759 2 235 20 20 6q21 150 D 1.00 171 0.641 T B -28 0.42 0.10 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 17.435 17.435 79.89 +P01112 150 Q V ? P01112 150 Q V ? ? benign alignment ? neutral 0 1 1 0.575 NO NO ? +0.637 -1.883 -2.520 2 235 20 20 6q21 150 D 1.00 171 0.641 T B -4 1.08 0.10 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 19.231 19.231 79.89 +P01112 150 Q W ? P01112 150 Q W ? ? probably damaging alignment ? deleterious 0.99 0.0338 0.719 0.06 NO NO ? +3.534 -1.883 -5.417 2 235 20 20 6q21 150 D 1.00 171 0.641 T B 83 1.11 0.10 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 0.627 ? 79.89 +P01112 150 Q Y ? P01112 150 Q Y ? ? possibly damaging alignment ? deleterious 0.619 0.0903 0.87 0.123 NO NO ? +2.328 -1.883 -4.211 2 235 20 20 6q21 150 D 1.00 171 0.641 T B 49 0.85 0.10 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 3.286 ? 79.89 +P01112 151 G A ? P01112 151 G A G C benign alignment ? neutral 0.255 0.118 0.911 0.15 NO NO ? +1.292 -1.274 -2.566 2 232 20 20 6q21 151 D 1.00 171 0.230 T l 28 0.29 -0.77 ? ? ? ? ? ? ? 1 1 0 -2 PF00071.17 21.303 21.303 85.71 +P01112 151 G C ? P01112 151 G C ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.863 -1.274 -5.137 2 232 20 20 6q21 151 D 1.00 171 0.230 T l 48 0.75 -0.77 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.576 ? 85.71 +P01112 151 G D ? P01112 151 G D ? ? probably damaging alignment ? deleterious 0.99 0.0338 0.719 0.06 NO NO ? +2.246 -1.274 -3.520 2 232 20 20 6q21 151 D 1.00 171 0.230 T l 51 0.46 -0.77 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 5.555 ? 85.71 +P01112 151 G E ? P01112 151 G E G A probably damaging alignment ? deleterious 0.998 0.0112 0.273 0.0274 NO NO ? +2.252 -1.274 -3.526 2 232 20 20 6q21 151 D 1.00 171 0.230 T l 78 0.75 -0.77 ? ? ? ? ? ? ? 0 1 0 -2 PF00071.17 4.473 ? 85.71 +P01112 151 G F ? P01112 151 G F ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.096 -1.274 -4.370 2 232 20 20 6q21 151 D 1.00 171 0.230 T l 130 0.87 -0.77 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.192 ? 85.71 +P01112 151 G H ? P01112 151 G H ? ? possibly damaging alignment ? deleterious 0.956 0.0501 0.785 0.0796 NO NO ? +1.876 -1.274 -3.150 2 232 20 20 6q21 151 D 1.00 171 0.230 T l 93 0.12 -0.77 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 25.101 25.101 85.71 +P01112 151 G I ? P01112 151 G I ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.915 -1.274 -4.189 2 232 20 20 6q21 151 D 1.00 171 0.230 T l 107 0.77 -0.77 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 3.159 ? 85.71 +P01112 151 G K ? P01112 151 G K ? ? probably damaging alignment ? deleterious 0.964 0.0472 0.777 0.0761 NO NO ? +1.498 -1.274 -2.772 2 232 20 20 6q21 151 D 1.00 171 0.230 T l 108 2.05 -0.77 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 13.341 13.341 85.71 +P01112 151 G L ? P01112 151 G L ? ? probably damaging alignment ? deleterious 0.998 0.0112 0.273 0.0274 NO NO ? +2.446 -1.274 -3.720 2 232 20 20 6q21 151 D 1.00 171 0.230 T l 107 0.84 -0.77 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 4.379 ? 85.71 +P01112 151 G M ? P01112 151 G M ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.588 -1.274 -4.862 2 232 20 20 6q21 151 D 1.00 171 0.230 T l 103 0.84 -0.77 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.334 ? 85.71 +P01112 151 G N ? P01112 151 G N ? ? possibly damaging alignment ? deleterious 0.53 0.0954 0.881 0.128 NO NO ? +0.761 -1.274 -2.035 2 232 20 20 6q21 151 D 1.00 171 0.230 T l 54 0.32 -0.77 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 21.115 21.115 85.71 +P01112 151 G P ? P01112 151 G P ? ? probably damaging alignment ? deleterious 0.998 0.0112 0.273 0.0274 NO NO ? +2.704 -1.274 -3.978 2 232 20 20 6q21 151 D 1.00 171 0.230 T l 52 0.23 -0.77 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.137 ? 85.71 +P01112 151 G Q ? P01112 151 G Q ? ? probably damaging alignment ? deleterious 0.998 0.0112 0.273 0.0274 NO NO ? +2.682 -1.274 -3.956 2 232 20 20 6q21 151 D 1.00 171 0.230 T l 84 0.35 -0.77 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 4.128 ? 85.71 +P01112 151 G R ? P01112 151 G R G A possibly damaging alignment ? deleterious 0.825 0.0696 0.838 0.101 NO NO ? +1.383 -1.274 -2.657 2 232 20 20 6q21 151 D 1.00 171 0.230 T l 113 0.91 -0.77 ? ? ? ? ? ? ? 0 0 0 -1 PF00071.17 29.489 29.489 85.71 +P01112 151 G S ? P01112 151 G S ? ? possibly damaging alignment ? deleterious 0.932 0.0575 0.804 0.0883 NO NO ? +1.394 -1.274 -2.668 2 232 20 20 6q21 151 D 1.00 171 0.230 T l 29 0.02 -0.77 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 10.938 10.938 85.71 +P01112 151 G T ? P01112 151 G T ? ? probably damaging alignment ? deleterious 0.998 0.0112 0.273 0.0274 NO NO ? +2.287 -1.274 -3.561 2 232 20 20 6q21 151 D 1.00 171 0.230 T l 56 0.07 -0.77 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 4.085 ? 85.71 +P01112 151 G V ? P01112 151 G V G T probably damaging alignment ? deleterious 0.995 0.0277 0.681 0.0521 NO NO ? +2.533 -1.274 -3.807 2 232 20 20 6q21 151 D 1.00 171 0.230 T l 80 0.73 -0.77 ? ? ? ? ? ? ? 1 1 0 -2 PF00071.17 5.022 ? 85.71 +P01112 151 G W ? P01112 151 G W ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +4.116 -1.274 -5.390 2 232 20 20 6q21 151 D 1.00 171 0.230 T l 167 0.76 -0.77 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 0.441 ? 85.71 +P01112 151 G Y ? P01112 151 G Y ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.024 -1.274 -4.298 2 232 20 20 6q21 151 D 1.00 171 0.230 T l 133 0.5 -0.77 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 4.115 ? 85.71 +P01112 152 V A ? P01112 152 V A T C possibly damaging alignment ? deleterious 0.935 0.057 0.803 0.0878 NO NO ? +1.431 -0.921 -2.352 2 232 20 20 6q21 152 D 1.00 171 0.008 H A -52 0.44 -0.65 ? ? ? ? ? ? ? 0 1 2 -5 PF00071.17 23.602 23.602 82.54 +P01112 152 V C ? P01112 152 V C ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.799 -0.921 -4.720 2 232 20 20 6q21 152 D 1.00 171 0.008 H A -32 0.02 -0.65 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.746 ? 82.54 +P01112 152 V D ? P01112 152 V D ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.998 -0.921 -3.919 2 232 20 20 6q21 152 D 1.00 171 0.008 H A -29 1.19 -0.65 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.808 ? 82.54 +P01112 152 V E ? P01112 152 V E T A probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.794 -0.921 -3.715 2 232 20 20 6q21 152 D 1.00 171 0.008 H A -2 1.48 -0.65 ? ? ? ? ? ? ? 1 1 0 -5 PF00071.17 3.280 ? 82.54 +P01112 152 V F ? P01112 152 V F ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.047 -0.921 -3.968 2 232 20 20 6q21 152 D 1.00 171 0.008 H A 50 0.14 -0.65 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.796 ? 82.54 +P01112 152 V G ? P01112 152 V G T G probably damaging structure 1.1.3 deleterious 0.98 0.0405 0.753 0.0679 NO NO ? +1.629 -0.921 -2.550 2 232 20 20 6q21 152 D 1.00 171 0.008 H A -80 0.73 -0.65 ? ? ? ? ? ? ? 1 1 0 -5 PF00071.17 42.083 42.083 82.54 +P01112 152 V H ? P01112 152 V H ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +4.012 -0.921 -4.933 2 232 20 20 6q21 152 D 1.00 171 0.008 H A 13 0.61 -0.65 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.216 ? 82.54 +P01112 152 V I ? P01112 152 V I ? ? probably damaging alignment ? deleterious 0.977 0.0424 0.758 0.0704 NO NO ? +1.948 -0.921 -2.869 2 232 20 20 6q21 152 D 1.00 171 0.008 H A 27 0.04 -0.65 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 3.500 ? 82.54 +P01112 152 V K ? P01112 152 V K ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.811 -0.921 -3.732 2 232 20 20 6q21 152 D 1.00 171 0.008 H A 28 2.78 -0.65 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 3.674 ? 82.54 +P01112 152 V L ? P01112 152 V L G C probably damaging alignment ? deleterious 0.996 0.0222 0.545 0.0439 NO NO ? +1.935 -0.921 -2.856 2 232 20 20 6q21 152 D 1.00 171 0.008 H A 27 0.11 -0.65 ? ? ? ? ? ? ? 1 0 0 -4 PF00071.17 4.851 ? 82.54 +P01112 152 V M ? P01112 152 V M G A probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.274 -0.921 -4.195 2 232 20 20 6q21 152 D 1.00 171 0.008 H A 23 0.11 -0.65 ? ? ? ? ? ? ? 0 0 0 -4 PF00071.17 1.473 ? 82.54 +P01112 152 V N ? P01112 152 V N ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.169 -0.921 -4.090 2 232 20 20 6q21 152 D 1.00 171 0.008 H A -26 1.05 -0.65 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 3.183 ? 82.54 +P01112 152 V P ? P01112 152 V P ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.009 -0.921 -3.930 2 232 20 20 6q21 152 D 1.00 171 0.008 H A -28 0.96 -0.65 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.368 ? 82.54 +P01112 152 V Q ? P01112 152 V Q ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.253 -0.921 -4.174 2 232 20 20 6q21 152 D 1.00 171 0.008 H A 4 1.08 -0.65 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.113 ? 82.54 +P01112 152 V R ? P01112 152 V R ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.237 -0.921 -4.158 2 232 20 20 6q21 152 D 1.00 171 0.008 H A 33 1.64 -0.65 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.577 ? 82.54 +P01112 152 V S ? P01112 152 V S ? ? probably damaging alignment ? deleterious 0.999 0.00574 0.136 0.0192 NO NO ? +2.631 -0.921 -3.552 2 232 20 20 6q21 152 D 1.00 171 0.008 H A -51 0.71 -0.65 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 6.865 ? 82.54 +P01112 152 V T ? P01112 152 V T ? ? probably damaging alignment ? deleterious 0.999 0.00574 0.136 0.0192 NO NO ? +2.382 -0.921 -3.303 2 232 20 20 6q21 152 D 1.00 171 0.008 H A -24 0.66 -0.65 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 4.082 ? 82.54 +P01112 152 V W ? P01112 152 V W ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +4.452 -0.921 -5.373 2 232 20 20 6q21 152 D 1.00 171 0.008 H A 87 0.03 -0.65 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 0.454 ? 82.54 +P01112 152 V Y ? P01112 152 V Y ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.143 -0.921 -4.064 2 232 20 20 6q21 152 D 1.00 171 0.008 H A 53 0.23 -0.65 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.427 ? 82.54 +P01112 153 E A ? P01112 153 E A A C possibly damaging alignment ? deleterious 0.857 0.0669 0.831 0.0983 NO NO ? +1.978 -1.205 -3.183 2 231 20 20 6q21 153 D 1.00 171 0.358 H A -50 1.04 -0.01 ? ? ? ? ? ? ? 1 1 2 -8 PF00071.17 5.723 ? 83.07 +P01112 153 E C ? P01112 153 E C ? ? probably damaging alignment ? deleterious 0.997 0.0167 0.409 0.0357 NO NO ? +4.014 -1.205 -5.219 2 231 20 20 6q21 153 D 1.00 171 0.358 H A -30 1.5 -0.01 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 0.987 ? 83.07 +P01112 153 E D ? P01112 153 E D G C benign alignment ? neutral 0.001 0.852 0.994 0.514 NO NO ? +0.440 -1.205 -1.645 2 231 20 20 6q21 153 D 1.00 171 0.358 H A -27 0.29 -0.01 ? ? ? ? ? ? ? 1 2 2 -9 PF00071.17 32.955 32.955 83.07 +P01112 153 E F ? P01112 153 E F ? ? probably damaging alignment ? deleterious 0.999 0.00574 0.136 0.0192 NO NO ? +3.158 -1.205 -4.363 2 231 20 20 6q21 153 D 1.00 171 0.358 H A 52 1.62 -0.01 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.233 ? 83.07 +P01112 153 E G ? P01112 153 E G A G probably damaging alignment ? deleterious 0.976 0.043 0.76 0.0712 NO NO ? +2.150 -1.205 -3.355 2 231 20 20 6q21 153 D 1.00 171 0.358 H A -78 0.75 -0.01 ? ? ? ? ? ? ? 0 1 0 -8 PF00071.17 3.907 ? 83.07 +P01112 153 E H ? P01112 153 E H ? ? probably damaging alignment ? deleterious 0.998 0.0112 0.273 0.0274 NO NO ? +3.245 -1.205 -4.450 2 231 20 20 6q21 153 D 1.00 171 0.358 H A 15 0.87 -0.01 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.478 ? 83.07 +P01112 153 E I ? P01112 153 E I ? ? probably damaging alignment ? deleterious 0.981 0.0399 0.75 0.0672 NO NO ? +2.853 -1.205 -4.058 2 231 20 20 6q21 153 D 1.00 171 0.358 H A 29 1.52 -0.01 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.858 ? 83.07 +P01112 153 E K ? P01112 153 E K G A probably damaging alignment ? deleterious 0.957 0.0496 0.784 0.079 NO NO ? +2.076 -1.205 -3.281 2 231 20 20 6q21 153 D 1.00 171 0.358 H A 30 1.3 -0.01 ? ? ? ? ? ? ? 0 0 0 -7 PF00071.17 3.788 ? 83.07 +P01112 153 E L ? P01112 153 E L ? ? possibly damaging alignment ? deleterious 0.932 0.0575 0.804 0.0883 NO NO ? +2.484 -1.205 -3.689 2 231 20 20 6q21 153 D 1.00 171 0.358 H A 29 1.59 -0.01 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 3.525 ? 83.07 +P01112 153 E M ? P01112 153 E M ? ? probably damaging alignment ? deleterious 0.983 0.0387 0.745 0.0657 NO NO ? +3.630 -1.205 -4.835 2 231 20 20 6q21 153 D 1.00 171 0.358 H A 25 1.59 -0.01 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.071 ? 83.07 +P01112 153 E N ? P01112 153 E N ? ? possibly damaging alignment ? deleterious 0.762 0.0768 0.851 0.109 NO NO ? +2.262 -1.205 -3.467 2 231 20 20 6q21 153 D 1.00 171 0.358 H A -24 0.43 -0.01 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 5.763 ? 83.07 +P01112 153 E P ? P01112 153 E P ? ? possibly damaging alignment ? deleterious 0.806 0.072 0.842 0.104 NO NO ? +2.559 -1.205 -3.764 2 231 20 20 6q21 153 D 1.00 171 0.358 H A -26 0.52 -0.01 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.917 ? 83.07 +P01112 153 E Q ? P01112 153 E Q G C probably damaging alignment ? deleterious 0.97 0.0446 0.769 0.0728 NO NO ? +2.321 -1.205 -3.526 2 231 20 20 6q21 153 D 1.00 171 0.358 H A 6 0.4 -0.01 ? ? ? ? ? ? ? 1 0 0 -7 PF00071.17 2.553 ? 83.07 +P01112 153 E R ? P01112 153 E R ? ? probably damaging alignment ? deleterious 0.984 0.0381 0.743 0.065 NO NO ? +2.538 -1.205 -3.743 2 231 20 20 6q21 153 D 1.00 171 0.358 H A 35 0.16 -0.01 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.458 ? 83.07 +P01112 153 E S ? P01112 153 E S ? ? possibly damaging alignment ? deleterious 0.694 0.0828 0.86 0.115 NO NO ? +1.397 -1.205 -2.602 2 231 20 20 6q21 153 D 1.00 171 0.358 H A -49 0.77 -0.01 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 11.520 11.520 83.07 +P01112 153 E T ? P01112 153 E T ? ? possibly damaging alignment ? deleterious 0.758 0.077 0.852 0.109 NO NO ? +1.481 -1.205 -2.686 2 231 20 20 6q21 153 D 1.00 171 0.358 H A -22 0.82 -0.01 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 13.271 13.271 83.07 +P01112 153 E V ? P01112 153 E V A T possibly damaging alignment ? deleterious 0.881 0.0646 0.824 0.096 NO NO ? +2.449 -1.205 -3.654 2 231 20 20 6q21 153 D 1.00 171 0.358 H A 2 1.48 -0.01 ? ? ? ? ? ? ? 1 1 0 -8 PF00071.17 3.860 ? 83.07 +P01112 153 E W ? P01112 153 E W ? ? probably damaging alignment ? deleterious 0.999 0.00574 0.136 0.0192 NO NO ? +4.268 -1.205 -5.473 2 231 20 20 6q21 153 D 1.00 171 0.358 H A 89 1.51 -0.01 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 0.303 ? 83.07 +P01112 153 E Y ? P01112 153 E Y ? ? probably damaging alignment ? deleterious 0.999 0.00574 0.136 0.0192 NO NO ? +3.129 -1.205 -4.334 2 231 20 20 6q21 153 D 1.00 171 0.358 H A 55 1.25 -0.01 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 0.999 ? 83.07 +P01112 154 D A ? P01112 154 D A A C possibly damaging alignment ? deleterious 0.799 0.0726 0.843 0.104 NO NO ? +1.710 -1.576 -3.286 2 232 20 20 6q21 154 D 1.00 171 0.567 H A -23 0.75 -0.39 ? ? ? 1 6.000 ? ? 1 1 0 -11 PF00071.17 4.509 ? 80.95 +P01112 154 D C ? P01112 154 D C ? ? probably damaging alignment ? deleterious 0.992 0.0314 0.704 0.0568 NO NO ? +3.676 -1.576 -5.252 2 232 20 20 6q21 154 D 1.00 171 0.567 H A -3 1.21 -0.39 ? ? ? 1 6.000 ? ? ? ? ? ? PF00071.17 0.752 ? 80.95 +P01112 154 D E ? P01112 154 D E T G benign alignment ? neutral 0.001 0.852 0.994 0.514 NO NO ? +0.215 -1.576 -1.791 2 232 20 20 6q21 154 D 1.00 171 0.567 H A 27 0.29 -0.39 ? ? ? 1 6.000 ? ? 1 2 0 -12 PF00071.17 24.048 24.048 80.95 +P01112 154 D F ? P01112 154 D F ? ? probably damaging alignment ? deleterious 0.999 0.00574 0.136 0.0192 NO NO ? +2.816 -1.576 -4.392 2 232 20 20 6q21 154 D 1.00 171 0.567 H A 79 1.33 -0.39 ? ? ? 1 6.000 ? ? ? ? ? ? PF00071.17 1.505 ? 80.95 +P01112 154 D G ? P01112 154 D G A G possibly damaging alignment ? deleterious 0.741 0.0787 0.853 0.111 NO NO ? +1.789 -1.576 -3.365 2 232 20 20 6q21 154 D 1.00 171 0.567 H A -51 0.46 -0.39 ? ? ? 1 6.000 ? ? 0 1 0 -11 PF00071.17 3.761 ? 80.95 +P01112 154 D H ? P01112 154 D H G C possibly damaging alignment ? neutral 0.478 0.0986 0.886 0.131 NO NO ? +1.560 -1.576 -3.136 2 232 20 20 6q21 154 D 1.00 171 0.567 H A 42 0.58 -0.39 ? ? ? 1 6.000 ? ? 1 0 0 -10 PF00071.17 17.233 17.233 80.95 +P01112 154 D I ? P01112 154 D I ? ? probably damaging alignment ? deleterious 0.993 0.0301 0.696 0.0553 NO NO ? +2.570 -1.576 -4.146 2 232 20 20 6q21 154 D 1.00 171 0.567 H A 56 1.23 -0.39 ? ? ? 1 6.000 ? ? ? ? ? ? PF00071.17 1.817 ? 80.95 +P01112 154 D K ? P01112 154 D K ? ? possibly damaging alignment ? deleterious 0.904 0.0621 0.816 0.0934 NO NO ? +1.748 -1.576 -3.324 2 232 20 20 6q21 154 D 1.00 171 0.567 H A 57 1.59 -0.39 ? ? ? 1 6.000 ? ? ? ? ? ? PF00071.17 6.159 ? 80.95 +P01112 154 D L ? P01112 154 D L ? ? probably damaging alignment ? deleterious 0.985 0.0375 0.74 0.0643 NO NO ? +2.151 -1.576 -3.727 2 232 20 20 6q21 154 D 1.00 171 0.567 H A 56 1.3 -0.39 ? ? ? 1 6.000 ? ? ? ? ? ? PF00071.17 2.986 ? 80.95 +P01112 154 D M ? P01112 154 D M ? ? probably damaging alignment ? deleterious 0.998 0.0112 0.273 0.0274 NO NO ? +3.223 -1.576 -4.799 2 232 20 20 6q21 154 D 1.00 171 0.567 H A 52 1.3 -0.39 ? ? ? 1 6.000 ? ? ? ? ? ? PF00071.17 1.097 ? 80.95 +P01112 154 D N ? P01112 154 D N G A benign alignment ? neutral 0.112 0.142 0.927 0.172 NO NO ? +1.186 -1.576 -2.762 2 232 20 20 6q21 154 D 1.00 171 0.567 H A 3 0.14 -0.39 ? ? ? 1 6.000 ? ? 0 0 0 -10 PF00071.17 18.601 18.601 80.95 +P01112 154 D P ? P01112 154 D P ? ? possibly damaging alignment ? deleterious 0.726 0.0797 0.856 0.112 NO NO ? +2.271 -1.576 -3.847 2 232 20 20 6q21 154 D 1.00 171 0.567 H A 1 0.23 -0.39 ? ? ? 1 6.000 ? ? ? ? ? ? PF00071.17 2.119 ? 80.95 +P01112 154 D Q ? P01112 154 D Q ? ? benign alignment ? neutral 0.215 0.123 0.915 0.154 NO NO ? +0.710 -1.576 -2.286 2 232 20 20 6q21 154 D 1.00 171 0.567 H A 33 0.11 -0.39 ? ? ? 1 6.000 ? ? ? ? ? ? PF00071.17 10.866 10.866 80.95 +P01112 154 D R ? P01112 154 D R ? ? possibly damaging alignment ? deleterious 0.572 0.0938 0.876 0.127 NO NO ? +1.321 -1.576 -2.897 2 232 20 20 6q21 154 D 1.00 171 0.567 H A 62 0.45 -0.39 ? ? ? 1 6.000 ? ? ? ? ? ? PF00071.17 17.111 17.111 80.95 +P01112 154 D S ? P01112 154 D S ? ? possibly damaging alignment ? deleterious 0.52 0.096 0.882 0.129 NO NO ? +1.125 -1.576 -2.701 2 232 20 20 6q21 154 D 1.00 171 0.567 H A -22 0.48 -0.39 ? ? ? 1 6.000 ? ? ? ? ? ? PF00071.17 9.076 9.076 80.95 +P01112 154 D T ? P01112 154 D T ? ? possibly damaging alignment ? deleterious 0.891 0.0637 0.821 0.0952 NO NO ? +1.958 -1.576 -3.534 2 232 20 20 6q21 154 D 1.00 171 0.567 H A 5 0.53 -0.39 ? ? ? 1 6.000 ? ? ? ? ? ? PF00071.17 3.390 ? 80.95 +P01112 154 D V ? P01112 154 D V A T possibly damaging alignment ? deleterious 0.947 0.0535 0.794 0.0836 NO NO ? +2.216 -1.576 -3.792 2 232 20 20 6q21 154 D 1.00 171 0.567 H A 29 1.19 -0.39 ? ? ? 1 6.000 ? ? 1 1 0 -11 PF00071.17 2.532 ? 80.95 +P01112 154 D W ? P01112 154 D W ? ? probably damaging alignment ? deleterious 0.999 0.00574 0.136 0.0192 NO NO ? +3.920 -1.576 -5.496 2 232 20 20 6q21 154 D 1.00 171 0.567 H A 116 1.22 -0.39 ? ? ? 1 6.000 ? ? ? ? ? ? PF00071.17 0.395 ? 80.95 +P01112 154 D Y ? P01112 154 D Y G T probably damaging alignment ? deleterious 0.98 0.0405 0.753 0.0679 NO NO ? +2.670 -1.576 -4.246 2 232 20 20 6q21 154 D 1.00 171 0.567 H A 82 0.96 -0.39 ? ? ? 1 6.000 ? ? 1 0 0 -10 PF00071.17 2.825 ? 80.95 +P01112 155 A C ? P01112 155 A C ? ? probably damaging alignment ? deleterious 0.979 0.0411 0.755 0.0687 NO NO ? +1.662 -1.072 -2.734 2 232 20 20 6q21 155 D 1.00 171 0.000 H A 20 0.46 -0.52 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 30.685 30.685 68.78 +P01112 155 A D ? P01112 155 A D C A probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.630 -1.072 -3.702 2 232 20 20 6q21 155 D 1.00 171 0.000 H A 23 0.75 -0.52 ? ? ? ? ? ? ? 1 1 0 -14 PF00071.17 3.266 ? 68.78 +P01112 155 A E ? P01112 155 A E ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.502 -1.072 -3.574 2 232 20 20 6q21 155 D 1.00 171 0.000 H A 50 1.04 -0.52 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 3.441 ? 68.78 +P01112 155 A F ? P01112 155 A F ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.121 -1.072 -4.193 2 232 20 20 6q21 155 D 1.00 171 0.000 H A 102 0.58 -0.52 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.391 ? 68.78 +P01112 155 A G ? P01112 155 A G C G possibly damaging alignment ? deleterious 0.588 0.0929 0.874 0.126 NO NO ? +1.358 -1.072 -2.430 2 232 20 20 6q21 155 D 1.00 171 0.000 H A -28 0.29 -0.52 ? ? ? ? ? ? ? 1 1 0 -14 PF00071.17 35.070 35.070 68.78 +P01112 155 A H ? P01112 155 A H ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.693 -1.072 -4.765 2 232 20 20 6q21 155 D 1.00 171 0.000 H A 65 0.17 -0.52 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.287 ? 68.78 +P01112 155 A I ? P01112 155 A I ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.679 -1.072 -3.751 2 232 20 20 6q21 155 D 1.00 171 0.000 H A 79 0.48 -0.52 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.818 ? 68.78 +P01112 155 A K ? P01112 155 A K ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.504 -1.072 -3.576 2 232 20 20 6q21 155 D 1.00 171 0.000 H A 80 2.34 -0.52 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 3.613 ? 68.78 +P01112 155 A L ? P01112 155 A L ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.252 -1.072 -3.324 2 232 20 20 6q21 155 D 1.00 171 0.000 H A 79 0.55 -0.52 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 4.033 ? 68.78 +P01112 155 A M ? P01112 155 A M ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.546 -1.072 -4.618 2 232 20 20 6q21 155 D 1.00 171 0.000 H A 75 0.55 -0.52 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 0.997 ? 68.78 +P01112 155 A N ? P01112 155 A N ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.746 -1.072 -3.818 2 232 20 20 6q21 155 D 1.00 171 0.000 H A 26 0.61 -0.52 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 3.666 ? 68.78 +P01112 155 A P ? P01112 155 A P G C probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.752 -1.072 -3.824 2 232 20 20 6q21 155 D 1.00 171 0.000 H A 24 0.52 -0.52 ? ? ? ? ? ? ? 1 0 0 -13 PF00071.17 1.941 ? 68.78 +P01112 155 A Q ? P01112 155 A Q ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.946 -1.072 -4.018 2 232 20 20 6q21 155 D 1.00 171 0.000 H A 56 0.64 -0.52 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.205 ? 68.78 +P01112 155 A R ? P01112 155 A R ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.806 -1.072 -3.878 2 232 20 20 6q21 155 D 1.00 171 0.000 H A 85 1.2 -0.52 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.640 ? 68.78 +P01112 155 A S ? P01112 155 A S G T probably damaging alignment ? deleterious 0.984 0.0381 0.743 0.065 NO NO ? +0.958 -1.072 -2.030 2 232 20 20 6q21 155 D 1.00 171 0.000 H A 1 0.27 -0.52 ? ? ? ? ? ? ? 1 0 0 -13 PF00071.17 14.661 14.661 68.78 +P01112 155 A T ? P01112 155 A T G A probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.237 -1.072 -3.309 2 232 20 20 6q21 155 D 1.00 171 0.000 H A 28 0.22 -0.52 ? ? ? ? ? ? ? 0 0 0 -13 PF00071.17 5.476 ? 68.78 +P01112 155 A V ? P01112 155 A V C T probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.259 -1.072 -3.331 2 232 20 20 6q21 155 D 1.00 171 0.000 H A 52 0.44 -0.52 ? ? ? ? ? ? ? 0 1 0 -14 PF00071.17 3.499 ? 68.78 +P01112 155 A W ? P01112 155 A W ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +4.312 -1.072 -5.384 2 232 20 20 6q21 155 D 1.00 171 0.000 H A 139 0.47 -0.52 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 0.378 ? 68.78 +P01112 155 A Y ? P01112 155 A Y ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.216 -1.072 -4.288 2 232 20 20 6q21 155 D 1.00 171 0.000 H A 105 0.21 -0.52 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.200 ? 68.78 +P01112 156 F A ? P01112 156 F A ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.452 -0.877 -3.329 2 232 20 20 6q21 156 D 1.00 171 0.000 H A -102 0.58 -0.97 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 3.073 ? 68.78 +P01112 156 F C ? P01112 156 F C T G probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +4.012 -0.877 -4.889 2 232 20 20 6q21 156 D 1.00 171 0.000 H A -82 0.12 -0.97 ? ? ? ? ? ? ? 1 1 0 -17 PF00071.17 1.091 ? 68.78 +P01112 156 F D ? P01112 156 F D ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.114 -0.877 -3.991 2 232 20 20 6q21 156 D 1.00 171 0.000 H A -79 1.33 -0.97 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.057 ? 68.78 +P01112 156 F E ? P01112 156 F E ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.064 -0.877 -3.941 2 232 20 20 6q21 156 D 1.00 171 0.000 H A -52 1.62 -0.97 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.393 ? 68.78 +P01112 156 F G ? P01112 156 F G ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.778 -0.877 -3.655 2 232 20 20 6q21 156 D 1.00 171 0.000 H A -130 0.87 -0.97 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.451 ? 68.78 +P01112 156 F H ? P01112 156 F H ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.667 -0.877 -4.544 2 232 20 20 6q21 156 D 1.00 171 0.000 H A -37 0.75 -0.97 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 0.686 ? 68.78 +P01112 156 F I ? P01112 156 F I T A probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.454 -0.877 -3.331 2 232 20 20 6q21 156 D 1.00 171 0.000 H A -23 0.1 -0.97 ? ? ? ? ? ? ? 1 0 0 -16 PF00071.17 7.916 ? 68.78 +P01112 156 F K ? P01112 156 F K ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.056 -0.877 -3.933 2 232 20 20 6q21 156 D 1.00 171 0.000 H A -22 2.92 -0.97 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.713 ? 68.78 +P01112 156 F L ? P01112 156 F L T C probably damaging alignment ? deleterious 0.99 0.0338 0.719 0.06 NO NO ? +1.467 -0.877 -2.344 2 232 20 20 6q21 156 D 1.00 171 0.000 H A -23 0.03 -0.97 ? ? ? ? ? ? ? 0 0 0 -16 PF00071.17 25.829 25.829 68.78 +P01112 156 F M ? P01112 156 F M ? ? probably damaging alignment ? deleterious 0.996 0.0222 0.545 0.0439 NO NO ? +3.374 -0.877 -4.251 2 232 20 20 6q21 156 D 1.00 171 0.000 H A -27 0.03 -0.97 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 3.428 ? 68.78 +P01112 156 F N ? P01112 156 F N ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.297 -0.877 -4.174 2 232 20 20 6q21 156 D 1.00 171 0.000 H A -76 1.19 -0.97 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 0.952 ? 68.78 +P01112 156 F P ? P01112 156 F P ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.479 -0.877 -4.356 2 232 20 20 6q21 156 D 1.00 171 0.000 H A -78 1.1 -0.97 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 0.984 ? 68.78 +P01112 156 F Q ? P01112 156 F Q ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.499 -0.877 -4.376 2 232 20 20 6q21 156 D 1.00 171 0.000 H A -46 1.22 -0.97 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.125 ? 68.78 +P01112 156 F R ? P01112 156 F R ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.307 -0.877 -4.184 2 232 20 20 6q21 156 D 1.00 171 0.000 H A -17 1.78 -0.97 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.683 ? 68.78 +P01112 156 F S ? P01112 156 F S T C probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.785 -0.877 -3.662 2 232 20 20 6q21 156 D 1.00 171 0.000 H A -101 0.85 -0.97 ? ? ? ? ? ? ? 0 1 0 -17 PF00071.17 1.688 ? 68.78 +P01112 156 F T ? P01112 156 F T ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.796 -0.877 -3.673 2 232 20 20 6q21 156 D 1.00 171 0.000 H A -74 0.8 -0.97 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.311 ? 68.78 +P01112 156 F V ? P01112 156 F V T G probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.422 -0.877 -3.299 2 232 20 20 6q21 156 D 1.00 171 0.000 H A -50 0.14 -0.97 ? ? ? ? ? ? ? 1 0 2 -16 PF00071.17 6.592 ? 68.78 +P01112 156 F W ? P01112 156 F W ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.648 -0.877 -4.525 2 232 20 20 6q21 156 D 1.00 171 0.000 H A 37 0.11 -0.97 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 0.509 ? 68.78 +P01112 156 F Y ? P01112 156 F Y T A probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.274 -0.877 -3.151 2 232 20 20 6q21 156 D 1.00 171 0.000 H A 3 0.37 -0.97 ? ? ? ? ? ? ? 1 1 0 -17 PF00071.17 1.537 ? 68.78 +P01112 157 Y A ? P01112 157 Y A ? ? possibly damaging alignment ? deleterious 0.841 0.0682 0.836 0.0995 NO NO ? +1.115 -1.593 -2.708 2 232 20 20 6q21 157 D 1.00 171 0.177 H A -105 0.21 -0.39 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 14.713 14.713 76.19 +P01112 157 Y C ? P01112 157 Y C A G probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.427 -1.593 -5.020 2 232 20 20 6q21 157 D 1.00 171 0.177 H A -85 0.25 -0.39 ? ? ? ? ? ? ? 0 1 0 -20 PF00071.17 1.244 ? 76.19 +P01112 157 Y D ? P01112 157 Y D T G probably damaging alignment ? deleterious 0.995 0.0277 0.681 0.0521 NO NO ? +2.261 -1.593 -3.854 2 232 20 20 6q21 157 D 1.00 171 0.177 H A -82 0.96 -0.39 ? ? ? ? ? ? ? 1 0 2 -19 PF00071.17 3.344 ? 76.19 +P01112 157 Y E ? P01112 157 Y E ? ? probably damaging alignment ? deleterious 0.996 0.0222 0.545 0.0439 NO NO ? +2.090 -1.593 -3.683 2 232 20 20 6q21 157 D 1.00 171 0.177 H A -55 1.25 -0.39 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 3.835 ? 76.19 +P01112 157 Y F ? P01112 157 Y F A T benign alignment ? neutral 0.021 0.196 0.951 0.219 NO NO ? +0.686 -1.593 -2.279 2 232 20 20 6q21 157 D 1.00 171 0.177 H A -3 0.37 -0.39 ? ? ? ? ? ? ? 1 1 0 -20 PF00071.17 29.368 29.368 76.19 +P01112 157 Y G ? P01112 157 Y G ? ? possibly damaging alignment ? deleterious 0.553 0.0945 0.878 0.127 NO NO ? +1.163 -1.593 -2.756 2 232 20 20 6q21 157 D 1.00 171 0.177 H A -133 0.5 -0.39 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 25.358 25.358 76.19 +P01112 157 Y H ? P01112 157 Y H T C benign alignment ? neutral 0.05 0.166 0.941 0.193 NO NO ? +0.473 -1.593 -2.066 2 232 20 20 6q21 157 D 1.00 171 0.177 H A -40 0.38 -0.39 ? ? ? ? ? ? ? 0 0 0 -19 PF00071.17 26.037 26.037 76.19 +P01112 157 Y I ? P01112 157 Y I ? ? possibly damaging alignment ? deleterious 0.835 0.0687 0.836 0.1 NO NO ? +2.199 -1.593 -3.792 2 232 20 20 6q21 157 D 1.00 171 0.177 H A -26 0.27 -0.39 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 5.523 ? 76.19 +P01112 157 Y K ? P01112 157 Y K ? ? probably damaging alignment ? deleterious 0.969 0.045 0.77 0.0734 NO NO ? +2.157 -1.593 -3.750 2 232 20 20 6q21 157 D 1.00 171 0.177 H A -25 2.55 -0.39 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 3.699 ? 76.19 +P01112 157 Y L ? P01112 157 Y L ? ? possibly damaging alignment ? deleterious 0.591 0.0926 0.874 0.125 NO NO ? +1.747 -1.593 -3.340 2 232 20 20 6q21 157 D 1.00 171 0.177 H A -26 0.34 -0.39 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 10.854 ? 76.19 +P01112 157 Y M ? P01112 157 Y M ? ? possibly damaging alignment ? deleterious 0.918 0.0596 0.811 0.0905 NO NO ? +1.703 -1.593 -3.296 2 232 20 20 6q21 157 D 1.00 171 0.177 H A -30 0.34 -0.39 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 8.913 8.913 76.19 +P01112 157 Y N ? P01112 157 Y N T A probably damaging alignment ? deleterious 0.995 0.0277 0.681 0.0521 NO NO ? +2.205 -1.593 -3.798 2 232 20 20 6q21 157 D 1.00 171 0.177 H A -79 0.82 -0.39 ? ? ? ? ? ? ? 1 0 0 -19 PF00071.17 4.012 ? 76.19 +P01112 157 Y P ? P01112 157 Y P ? ? probably damaging alignment ? deleterious 0.998 0.0112 0.273 0.0274 NO NO ? +2.549 -1.593 -4.142 2 232 20 20 6q21 157 D 1.00 171 0.177 H A -81 0.73 -0.39 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.987 ? 76.19 +P01112 157 Y Q ? P01112 157 Y Q ? ? probably damaging alignment ? deleterious 0.987 0.036 0.731 0.0626 NO NO ? +2.449 -1.593 -4.042 2 232 20 20 6q21 157 D 1.00 171 0.177 H A -49 0.85 -0.39 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.943 ? 76.19 +P01112 157 Y R ? P01112 157 Y R ? ? probably damaging alignment ? deleterious 0.991 0.0326 0.711 0.0584 NO NO ? +2.369 -1.593 -3.962 2 232 20 20 6q21 157 D 1.00 171 0.177 H A -20 1.41 -0.39 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 3.481 ? 76.19 +P01112 157 Y S ? P01112 157 Y S A C possibly damaging alignment ? deleterious 0.8 0.0724 0.843 0.104 NO NO ? +1.044 -1.593 -2.637 2 232 20 20 6q21 157 D 1.00 171 0.177 H A -104 0.48 -0.39 ? ? ? ? ? ? ? 1 1 0 -20 PF00071.17 15.011 15.011 76.19 +P01112 157 Y T ? P01112 157 Y T ? ? probably damaging alignment ? deleterious 0.992 0.0314 0.704 0.0568 NO NO ? +2.097 -1.593 -3.690 2 232 20 20 6q21 157 D 1.00 171 0.177 H A -77 0.43 -0.39 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 5.606 ? 76.19 +P01112 157 Y V ? P01112 157 Y V ? ? probably damaging alignment ? deleterious 0.992 0.0314 0.704 0.0568 NO NO ? +1.959 -1.593 -3.552 2 232 20 20 6q21 157 D 1.00 171 0.177 H A -53 0.23 -0.39 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 5.092 ? 76.19 +P01112 157 Y W ? P01112 157 Y W ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.181 -1.593 -4.774 2 232 20 20 6q21 157 D 1.00 171 0.177 H A 34 0.26 -0.39 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.364 ? 76.19 +P01112 158 T A ? P01112 158 T A A G benign alignment ? neutral 0.004 0.408 0.975 0.328 NO NO ? +0.683 -1.833 -2.516 2 232 20 20 6q21 158 D 1.00 171 0.007 H A -28 0.22 -1.00 ? ? ? 2 3.929 ? ? 0 0 2 -22 PF00071.17 20.690 20.690 84.66 +P01112 158 T C ? P01112 158 T C ? ? probably damaging alignment ? deleterious 0.999 0.00574 0.136 0.0192 NO NO ? +3.225 -1.833 -5.058 2 232 20 20 6q21 158 D 1.00 171 0.007 H A -8 0.68 -1.00 ? ? ? 2 3.929 ? ? ? ? ? ? PF00071.17 1.543 ? 84.66 +P01112 158 T D ? P01112 158 T D ? ? benign alignment ? neutral 0.006 0.253 0.967 0.262 NO NO ? +0.642 -1.833 -2.475 2 232 20 20 6q21 158 D 1.00 171 0.007 H A -5 0.53 -1.00 ? ? ? 2 3.929 ? ? ? ? ? ? PF00071.17 26.448 26.448 84.66 +P01112 158 T E ? P01112 158 T E ? ? benign alignment ? neutral 0.216 0.122 0.914 0.154 NO NO ? +0.201 -1.833 -2.034 2 232 20 20 6q21 158 D 1.00 171 0.007 H A 22 0.82 -1.00 ? ? ? 2 3.929 ? ? ? ? ? ? PF00071.17 19.333 19.333 84.66 +P01112 158 T F ? P01112 158 T F ? ? probably damaging alignment ? deleterious 0.999 0.00574 0.136 0.0192 NO NO ? +2.498 -1.833 -4.331 2 232 20 20 6q21 158 D 1.00 171 0.007 H A 74 0.8 -1.00 ? ? ? 2 3.929 ? ? ? ? ? ? PF00071.17 3.203 ? 84.66 +P01112 158 T G ? P01112 158 T G ? ? benign alignment ? neutral 0.11 0.143 0.928 0.173 NO NO ? +0.981 -1.833 -2.814 2 232 20 20 6q21 158 D 1.00 171 0.007 H A -56 0.07 -1.00 ? ? ? 2 3.929 ? ? ? ? ? ? PF00071.17 32.372 32.372 84.66 +P01112 158 T H ? P01112 158 T H ? ? probably damaging alignment ? deleterious 0.976 0.043 0.76 0.0712 NO NO ? +2.883 -1.833 -4.716 2 232 20 20 6q21 158 D 1.00 171 0.007 H A 37 0.05 -1.00 ? ? ? 2 3.929 ? ? ? ? ? ? PF00071.17 2.090 ? 84.66 +P01112 158 T I ? P01112 158 T I ? ? benign alignment ? neutral 0.288 0.115 0.907 0.146 NO NO ? +1.283 -1.833 -3.116 2 232 20 20 6q21 158 D 1.00 171 0.007 H A 51 0.7 -1.00 ? ? ? 2 3.929 ? ? ? ? ? ? PF00071.17 19.395 19.395 84.66 +P01112 158 T K ? P01112 158 T K C A possibly damaging structure 1.1.1 deleterious 0.903 0.0622 0.817 0.0936 NO NO ? +1.062 -1.833 -2.895 2 232 20 20 6q21 158 D 1.00 171 0.007 H A 52 2.12 -1.00 ? ? ? 2 3.929 ? ? 1 1 1 -23 PF00071.17 20.377 20.377 84.66 +P01112 158 T L ? P01112 158 T L ? ? possibly damaging alignment ? deleterious 0.631 0.0891 0.867 0.122 NO NO ? +1.045 -1.833 -2.878 2 232 20 20 6q21 158 D 1.00 171 0.007 H A 51 0.77 -1.00 ? ? ? 2 3.929 ? ? ? ? ? ? PF00071.17 19.074 19.074 84.66 +P01112 158 T M ? P01112 158 T M C T probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.860 -1.833 -4.693 2 232 20 20 6q21 158 D 1.00 171 0.007 H A 47 0.77 -1.00 ? ? ? 2 3.929 ? ? 0 1 1 -23 PF00071.17 2.638 ? 84.66 +P01112 158 T N ? P01112 158 T N ? ? possibly damaging alignment ? deleterious 0.781 0.0747 0.848 0.107 NO NO ? +1.863 -1.833 -3.696 2 232 20 20 6q21 158 D 1.00 171 0.007 H A -2 0.39 -1.00 ? ? ? 2 3.929 ? ? ? ? ? ? PF00071.17 4.655 ? 84.66 +P01112 158 T P ? P01112 158 T P A C possibly damaging alignment ? deleterious 0.916 0.0599 0.812 0.0909 NO NO ? +2.090 -1.833 -3.923 2 232 20 20 6q21 158 D 1.00 171 0.007 H A -4 0.3 -1.00 ? ? ? 2 3.929 ? ? 1 0 0 -22 PF00071.17 2.465 ? 84.66 +P01112 158 T Q ? P01112 158 T Q ? ? benign alignment ? neutral 0.121 0.141 0.926 0.171 NO NO ? +0.829 -1.833 -2.662 2 232 20 20 6q21 158 D 1.00 171 0.007 H A 28 0.42 -1.00 ? ? ? 2 3.929 ? ? ? ? ? ? PF00071.17 14.602 14.602 84.66 +P01112 158 T R ? P01112 158 T R C G probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.008 -1.833 -3.841 2 232 20 20 6q21 158 D 1.00 171 0.007 H A 57 0.98 -1.00 ? ? ? 2 3.929 ? ? 1 1 1 -23 PF00071.17 7.884 ? 84.66 +P01112 158 T S ? P01112 158 T S A T benign alignment ? neutral 0.007 0.246 0.965 0.257 NO NO ? +0.622 -1.833 -2.455 2 232 20 20 6q21 158 D 1.00 171 0.007 H A -27 0.05 -1.00 ? ? ? 2 3.929 ? ? 1 0 0 -22 PF00071.17 18.618 18.618 84.66 +P01112 158 T V ? P01112 158 T V ? ? possibly damaging alignment ? deleterious 0.897 0.063 0.819 0.0943 NO NO ? +1.654 -1.833 -3.487 2 232 20 20 6q21 158 D 1.00 171 0.007 H A 24 0.66 -1.00 ? ? ? 2 3.929 ? ? ? ? ? ? PF00071.17 12.592 ? 84.66 +P01112 158 T W ? P01112 158 T W ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.623 -1.833 -5.456 2 232 20 20 6q21 158 D 1.00 171 0.007 H A 111 0.69 -1.00 ? ? ? 2 3.929 ? ? ? ? ? ? PF00071.17 0.453 ? 84.66 +P01112 158 T Y ? P01112 158 T Y ? ? probably damaging alignment ? deleterious 0.999 0.00574 0.136 0.0192 NO NO ? +2.532 -1.833 -4.365 2 232 20 20 6q21 158 D 1.00 171 0.007 H A 77 0.43 -1.00 ? ? ? 2 3.929 ? ? ? ? ? ? PF00071.17 1.524 ? 84.66 +P01112 159 L A ? P01112 159 L A ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.231 -0.935 -3.166 2 232 20 20 6q21 159 D 1.00 171 0.000 H A -79 0.55 -0.72 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 4.353 ? 77.78 +P01112 159 L C ? P01112 159 L C ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.844 -0.935 -4.779 2 232 20 20 6q21 159 D 1.00 171 0.000 H A -59 0.09 -0.72 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.066 ? 77.78 +P01112 159 L D ? P01112 159 L D ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.185 -0.935 -4.120 2 232 20 20 6q21 159 D 1.00 171 0.000 H A -56 1.3 -0.72 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.497 ? 77.78 +P01112 159 L E ? P01112 159 L E ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.981 -0.935 -3.916 2 232 20 20 6q21 159 D 1.00 171 0.000 H A -29 1.59 -0.72 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.869 ? 77.78 +P01112 159 L F ? P01112 159 L F G C probably damaging alignment ? deleterious 0.992 0.0314 0.704 0.0568 NO NO ? +1.858 -0.935 -2.793 2 232 20 20 6q21 159 D 1.00 171 0.000 H A 23 0.03 -0.72 ? ? ? ? ? ? ? 1 2 2 -27 PF00071.17 25.289 25.289 77.78 +P01112 159 L G ? P01112 159 L G ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.880 -0.935 -3.815 2 232 20 20 6q21 159 D 1.00 171 0.000 H A -107 0.84 -0.72 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.753 ? 77.78 +P01112 159 L H ? P01112 159 L H ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.996 -0.935 -4.931 2 232 20 20 6q21 159 D 1.00 171 0.000 H A -14 0.72 -0.72 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.121 ? 77.78 +P01112 159 L I ? P01112 159 L I ? ? probably damaging alignment ? deleterious 0.997 0.0167 0.409 0.0357 NO NO ? +2.112 -0.935 -3.047 2 232 20 20 6q21 159 D 1.00 171 0.000 H A 0 0.07 -0.72 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 9.382 ? 77.78 +P01112 159 L K ? P01112 159 L K ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.836 -0.935 -3.771 2 232 20 20 6q21 159 D 1.00 171 0.000 H A 1 2.89 -0.72 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 3.183 ? 77.78 +P01112 159 L M ? P01112 159 L M T A probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.065 -0.935 -4.000 2 232 20 20 6q21 159 D 1.00 171 0.000 H A -4 0 -0.72 ? ? ? ? ? ? ? 1 0 0 -25 PF00071.17 1.812 ? 77.78 +P01112 159 L N ? P01112 159 L N ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.260 -0.935 -4.195 2 232 20 20 6q21 159 D 1.00 171 0.000 H A -53 1.16 -0.72 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.736 ? 77.78 +P01112 159 L P ? P01112 159 L P ? ? probably damaging structure 1.1.1 deleterious 1 0.00026 0.00018 0.0109 NO NO ? +1.906 -0.935 -2.841 2 232 20 20 6q21 159 D 1.00 171 0.000 H A -55 1.07 -0.72 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 38.479 38.479 77.78 +P01112 159 L Q ? P01112 159 L Q ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.278 -0.935 -4.213 2 232 20 20 6q21 159 D 1.00 171 0.000 H A -23 1.19 -0.72 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.709 ? 77.78 +P01112 159 L R ? P01112 159 L R ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.125 -0.935 -4.060 2 232 20 20 6q21 159 D 1.00 171 0.000 H A 6 1.75 -0.72 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.933 ? 77.78 +P01112 159 L S ? P01112 159 L S T C probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.748 -0.935 -3.683 2 232 20 20 6q21 159 D 1.00 171 0.000 H A -78 0.82 -0.72 ? ? ? ? ? ? ? 0 1 2 -26 PF00071.17 3.363 ? 77.78 +P01112 159 L T ? P01112 159 L T ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.575 -0.935 -3.510 2 232 20 20 6q21 159 D 1.00 171 0.000 H A -51 0.77 -0.72 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.853 ? 77.78 +P01112 159 L V ? P01112 159 L V T G probably damaging alignment ? deleterious 0.974 0.0438 0.763 0.0722 NO NO ? +1.524 -0.935 -2.459 2 232 20 20 6q21 159 D 1.00 171 0.000 H A -27 0.11 -0.72 ? ? ? ? ? ? ? 1 0 0 -25 PF00071.17 15.384 15.384 77.78 +P01112 159 L W ? P01112 159 L W T G probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +4.222 -0.935 -5.157 2 232 20 20 6q21 159 D 1.00 171 0.000 H A 60 0.08 -0.72 ? ? ? ? ? ? ? 1 1 0 -26 PF00071.17 1.175 ? 77.78 +P01112 159 L Y ? P01112 159 L Y ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.007 -0.935 -3.942 2 232 20 20 6q21 159 D 1.00 171 0.000 H A 26 0.34 -0.72 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 5.865 ? 77.78 +P01112 160 V A ? P01112 160 V A T C probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.074 -0.851 -2.925 2 232 20 20 6q21 160 D 1.00 171 0.000 H A -52 0.44 -1.21 ? ? ? ? ? ? ? 0 1 2 -29 PF00071.17 2.470 ? 46.03 +P01112 160 V C ? P01112 160 V C ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.838 -0.851 -4.689 2 232 20 20 6q21 160 D 1.00 171 0.000 H A -32 0.02 -1.21 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 0.695 ? 46.03 +P01112 160 V D ? P01112 160 V D ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.119 -0.851 -3.970 2 232 20 20 6q21 160 D 1.00 171 0.000 H A -29 1.19 -1.21 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 0.855 ? 46.03 +P01112 160 V E ? P01112 160 V E T A probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.865 -0.851 -3.716 2 232 20 20 6q21 160 D 1.00 171 0.000 H A -2 1.48 -1.21 ? ? ? ? ? ? ? 1 1 0 -29 PF00071.17 1.251 ? 46.03 +P01112 160 V F ? P01112 160 V F ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.017 -0.851 -3.868 2 232 20 20 6q21 160 D 1.00 171 0.000 H A 50 0.14 -1.21 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.192 ? 46.03 +P01112 160 V G ? P01112 160 V G T G probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.784 -0.851 -3.635 2 232 20 20 6q21 160 D 1.00 171 0.000 H A -80 0.73 -1.21 ? ? ? ? ? ? ? 1 1 0 -29 PF00071.17 1.350 ? 46.03 +P01112 160 V H ? P01112 160 V H ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +4.080 -0.851 -4.931 2 232 20 20 6q21 160 D 1.00 171 0.000 H A 13 0.61 -1.21 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 0.705 ? 46.03 +P01112 160 V I ? P01112 160 V I ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +1.898 -0.851 -2.749 2 232 20 20 6q21 160 D 1.00 171 0.000 H A 27 0.04 -1.21 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 4.620 ? 46.03 +P01112 160 V K ? P01112 160 V K ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.857 -0.851 -3.708 2 232 20 20 6q21 160 D 1.00 171 0.000 H A 28 2.78 -1.21 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.674 ? 46.03 +P01112 160 V L ? P01112 160 V L G C probably damaging alignment ? deleterious 0.999 0.00574 0.136 0.0192 NO NO ? +1.859 -0.851 -2.710 2 232 20 20 6q21 160 D 1.00 171 0.000 H A 27 0.11 -1.21 ? ? ? ? ? ? ? 1 0 0 -28 PF00071.17 9.080 ? 46.03 +P01112 160 V M ? P01112 160 V M G A probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.034 -0.851 -2.885 2 232 20 20 6q21 160 D 1.00 171 0.000 H A 23 0.11 -1.21 ? ? ? ? ? ? ? 0 0 0 -28 PF00071.17 7.456 7.456 46.03 +P01112 160 V N ? P01112 160 V N ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.298 -0.851 -4.149 2 232 20 20 6q21 160 D 1.00 171 0.000 H A -26 1.05 -1.21 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 0.975 ? 46.03 +P01112 160 V P ? P01112 160 V P ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.080 -0.851 -3.931 2 232 20 20 6q21 160 D 1.00 171 0.000 H A -28 0.96 -1.21 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 0.752 ? 46.03 +P01112 160 V Q ? P01112 160 V Q ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.269 -0.851 -4.120 2 232 20 20 6q21 160 D 1.00 171 0.000 H A 4 1.08 -1.21 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.363 ? 46.03 +P01112 160 V R ? P01112 160 V R ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.303 -0.851 -4.154 2 232 20 20 6q21 160 D 1.00 171 0.000 H A 33 1.64 -1.21 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.479 ? 46.03 +P01112 160 V S ? P01112 160 V S ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.786 -0.851 -3.637 2 232 20 20 6q21 160 D 1.00 171 0.000 H A -51 0.71 -1.21 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.577 ? 46.03 +P01112 160 V T ? P01112 160 V T ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.417 -0.851 -3.268 2 232 20 20 6q21 160 D 1.00 171 0.000 H A -24 0.66 -1.21 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.860 ? 46.03 +P01112 160 V W ? P01112 160 V W ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +4.467 -0.851 -5.318 2 232 20 20 6q21 160 D 1.00 171 0.000 H A 87 0.03 -1.21 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 0.366 ? 46.03 +P01112 160 V Y ? P01112 160 V Y ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.138 -0.851 -3.989 2 232 20 20 6q21 160 D 1.00 171 0.000 H A 53 0.23 -1.21 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.053 ? 46.03 +P01112 161 R A ? P01112 161 R A ? ? probably damaging alignment ? deleterious 0.994 0.0289 0.689 0.0537 NO NO ? +1.425 -1.153 -2.578 2 232 20 20 6q21 161 D 1.00 171 0.158 H A -85 1.2 -0.71 ? ? ? 4 3.598 ? ? ? ? ? ? PF00071.17 13.180 13.180 83.07 +P01112 161 R C ? P01112 161 R C C T probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.971 -1.153 -5.124 2 232 20 20 6q21 161 D 1.00 171 0.158 H A -65 1.66 -0.71 ? ? ? 4 3.598 ? ? 0 0 1 -31 PF00071.17 0.975 ? 83.07 +P01112 161 R D ? P01112 161 R D ? ? probably damaging alignment ? deleterious 0.999 0.00574 0.136 0.0192 NO NO ? +2.632 -1.153 -3.785 2 232 20 20 6q21 161 D 1.00 171 0.158 H A -62 0.45 -0.71 ? ? ? 4 3.598 ? ? ? ? ? ? PF00071.17 3.493 ? 83.07 +P01112 161 R E ? P01112 161 R E ? ? probably damaging alignment ? deleterious 0.994 0.0289 0.689 0.0537 NO NO ? +2.261 -1.153 -3.414 2 232 20 20 6q21 161 D 1.00 171 0.158 H A -35 0.16 -0.71 ? ? ? 4 3.598 ? ? ? ? ? ? PF00071.17 5.902 ? 83.07 +P01112 161 R F ? P01112 161 R F ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.184 -1.153 -4.337 2 232 20 20 6q21 161 D 1.00 171 0.158 H A 17 1.78 -0.71 ? ? ? 4 3.598 ? ? ? ? ? ? PF00071.17 1.570 ? 83.07 +P01112 161 R G ? P01112 161 R G C G possibly damaging alignment ? deleterious 0.91 0.0609 0.814 0.092 NO NO ? +1.253 -1.153 -2.406 2 232 20 20 6q21 161 D 1.00 171 0.158 H A -113 0.91 -0.71 ? ? ? 4 3.598 ? ? 1 0 1 -31 PF00071.17 23.470 23.470 83.07 +P01112 161 R H ? P01112 161 R H G A probably damaging alignment ? deleterious 0.997 0.0167 0.409 0.0357 NO NO ? +1.960 -1.153 -3.113 2 232 20 20 6q21 161 D 1.00 171 0.158 H A -20 1.03 -0.71 ? ? ? 4 3.598 ? ? 0 1 1 -32 PF00071.17 17.983 17.983 83.07 +P01112 161 R I ? P01112 161 R I ? ? probably damaging alignment ? deleterious 0.999 0.00574 0.136 0.0192 NO NO ? +2.798 -1.153 -3.951 2 232 20 20 6q21 161 D 1.00 171 0.158 H A -6 1.68 -0.71 ? ? ? 4 3.598 ? ? ? ? ? ? PF00071.17 7.211 ? 83.07 +P01112 161 R K ? P01112 161 R K ? ? possibly damaging alignment ? deleterious 0.605 0.0917 0.873 0.125 NO NO ? +1.410 -1.153 -2.563 2 232 20 20 6q21 161 D 1.00 171 0.158 H A -5 1.14 -0.71 ? ? ? 4 3.598 ? ? ? ? ? ? PF00071.17 23.016 23.016 83.07 +P01112 161 R L ? P01112 161 R L G T probably damaging alignment ? deleterious 0.998 0.0112 0.273 0.0274 NO NO ? +2.310 -1.153 -3.463 2 232 20 20 6q21 161 D 1.00 171 0.158 H A -6 1.75 -0.71 ? ? ? 4 3.598 ? ? 1 1 1 -32 PF00071.17 5.708 ? 83.07 +P01112 161 R M ? P01112 161 R M ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.477 -1.153 -4.630 2 232 20 20 6q21 161 D 1.00 171 0.158 H A -10 1.75 -0.71 ? ? ? 4 3.598 ? ? ? ? ? ? PF00071.17 1.393 ? 83.07 +P01112 161 R N ? P01112 161 R N ? ? probably damaging alignment ? deleterious 0.999 0.00574 0.136 0.0192 NO NO ? +2.475 -1.153 -3.628 2 232 20 20 6q21 161 D 1.00 171 0.158 H A -59 0.59 -0.71 ? ? ? 4 3.598 ? ? ? ? ? ? PF00071.17 3.486 ? 83.07 +P01112 161 R P ? P01112 161 R P G C probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.830 -1.153 -3.983 2 232 20 20 6q21 161 D 1.00 171 0.158 H A -61 0.68 -0.71 ? ? ? 4 3.598 ? ? 1 1 1 -32 PF00071.17 2.253 ? 83.07 +P01112 161 R Q ? P01112 161 R Q ? ? probably damaging alignment ? deleterious 0.999 0.00574 0.136 0.0192 NO NO ? +2.567 -1.153 -3.720 2 232 20 20 6q21 161 D 1.00 171 0.158 H A -29 0.56 -0.71 ? ? ? 4 3.598 ? ? ? ? ? ? PF00071.17 4.423 ? 83.07 +P01112 161 R S ? P01112 161 R S C A probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.303 -1.153 -3.456 2 232 20 20 6q21 161 D 1.00 171 0.158 H A -84 0.93 -0.71 ? ? ? 4 3.598 ? ? 1 0 1 -31 PF00071.17 4.430 ? 83.07 +P01112 161 R T ? P01112 161 R T ? ? probably damaging alignment ? deleterious 0.999 0.00574 0.136 0.0192 NO NO ? +2.406 -1.153 -3.559 2 232 20 20 6q21 161 D 1.00 171 0.158 H A -57 0.98 -0.71 ? ? ? 4 3.598 ? ? ? ? ? ? PF00071.17 3.352 ? 83.07 +P01112 161 R V ? P01112 161 R V ? ? probably damaging alignment ? deleterious 0.98 0.0405 0.753 0.0679 NO NO ? +1.724 -1.153 -2.877 2 232 20 20 6q21 161 D 1.00 171 0.158 H A -33 1.64 -0.71 ? ? ? 4 3.598 ? ? ? ? ? ? PF00071.17 11.823 11.823 83.07 +P01112 161 R W ? P01112 161 R W ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +4.264 -1.153 -5.417 2 232 20 20 6q21 161 D 1.00 171 0.158 H A 54 1.67 -0.71 ? ? ? 4 3.598 ? ? ? ? ? ? PF00071.17 0.389 ? 83.07 +P01112 161 R Y ? P01112 161 R Y ? ? probably damaging alignment ? deleterious 0.999 0.00574 0.136 0.0192 NO NO ? +3.054 -1.153 -4.207 2 232 20 20 6q21 161 D 1.00 171 0.158 H A 20 1.41 -0.71 ? ? ? 4 3.598 ? ? ? ? ? ? PF00071.17 2.948 ? 83.07 +P01112 162 E A ? P01112 162 E A A C probably damaging alignment ? deleterious 0.998 0.0112 0.273 0.0274 NO NO ? +2.184 -0.962 -3.146 2 231 20 20 6q21 162 D 1.00 171 0.070 H A -50 1.04 -0.80 ? ? ? 3 2.753 ? ? 1 1 2 -35 PF00071.17 5.105 ? 79.89 +P01112 162 E C ? P01112 162 E C ? ? probably damaging alignment ? deleterious 0.985 0.0375 0.74 0.0643 NO NO ? +2.164 -0.962 -3.126 2 231 20 20 6q21 162 D 1.00 171 0.070 H A -30 1.5 -0.80 ? ? ? 3 2.753 ? ? ? ? ? ? PF00071.17 21.480 21.480 79.89 +P01112 162 E D ? P01112 162 E D G C possibly damaging alignment ? deleterious 0.65 0.0878 0.866 0.121 NO NO ? +1.450 -0.962 -2.412 2 231 20 20 6q21 162 D 1.00 171 0.070 H A -27 0.29 -0.80 ? ? ? 3 2.753 ? ? 1 2 0 -36 PF00071.17 31.696 31.696 79.89 +P01112 162 E F ? P01112 162 E F ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.402 -0.962 -4.364 2 231 20 20 6q21 162 D 1.00 171 0.070 H A 52 1.62 -0.80 ? ? ? 3 2.753 ? ? ? ? ? ? PF00071.17 1.133 ? 79.89 +P01112 162 E G ? P01112 162 E G A G probably damaging alignment ? deleterious 0.98 0.0405 0.753 0.0679 NO NO ? +1.591 -0.962 -2.553 2 231 20 20 6q21 162 D 1.00 171 0.070 H A -78 0.75 -0.80 ? ? ? 3 2.753 ? ? 0 1 0 -35 PF00071.17 33.181 33.181 79.89 +P01112 162 E H ? P01112 162 E H ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.454 -0.962 -4.416 2 231 20 20 6q21 162 D 1.00 171 0.070 H A 15 0.87 -0.80 ? ? ? 3 2.753 ? ? ? ? ? ? PF00071.17 1.421 ? 79.89 +P01112 162 E I ? P01112 162 E I ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.111 -0.962 -4.073 2 231 20 20 6q21 162 D 1.00 171 0.070 H A 29 1.52 -0.80 ? ? ? 3 2.753 ? ? ? ? ? ? PF00071.17 1.972 ? 79.89 +P01112 162 E K ? P01112 162 E K G A probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.267 -0.962 -3.229 2 231 20 20 6q21 162 D 1.00 171 0.070 H A 30 1.3 -0.80 ? ? ? 3 2.753 ? ? 0 0 0 -34 PF00071.17 3.643 ? 79.89 +P01112 162 E L ? P01112 162 E L ? ? probably damaging alignment ? deleterious 0.999 0.00574 0.136 0.0192 NO NO ? +2.700 -0.962 -3.662 2 231 20 20 6q21 162 D 1.00 171 0.070 H A 29 1.59 -0.80 ? ? ? 3 2.753 ? ? ? ? ? ? PF00071.17 2.823 ? 79.89 +P01112 162 E M ? P01112 162 E M ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.849 -0.962 -4.811 2 231 20 20 6q21 162 D 1.00 171 0.070 H A 25 1.59 -0.80 ? ? ? 3 2.753 ? ? ? ? ? ? PF00071.17 0.692 ? 79.89 +P01112 162 E N ? P01112 162 E N ? ? probably damaging alignment ? deleterious 0.997 0.0167 0.409 0.0357 NO NO ? +2.599 -0.962 -3.561 2 231 20 20 6q21 162 D 1.00 171 0.070 H A -24 0.43 -0.80 ? ? ? 3 2.753 ? ? ? ? ? ? PF00071.17 5.542 ? 79.89 +P01112 162 E P ? P01112 162 E P ? ? probably damaging alignment ? deleterious 0.999 0.00574 0.136 0.0192 NO NO ? +2.834 -0.962 -3.796 2 231 20 20 6q21 162 D 1.00 171 0.070 H A -26 0.52 -0.80 ? ? ? 3 2.753 ? ? ? ? ? ? PF00071.17 1.843 ? 79.89 +P01112 162 E Q ? P01112 162 E Q G C probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.503 -0.962 -3.465 2 231 20 20 6q21 162 D 1.00 171 0.070 H A 6 0.4 -0.80 ? ? ? 3 2.753 ? ? 1 0 0 -34 PF00071.17 2.455 ? 79.89 +P01112 162 E R ? P01112 162 E R ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.722 -0.962 -3.684 2 231 20 20 6q21 162 D 1.00 171 0.070 H A 35 0.16 -0.80 ? ? ? 3 2.753 ? ? ? ? ? ? PF00071.17 2.364 ? 79.89 +P01112 162 E S ? P01112 162 E S ? ? probably damaging alignment ? deleterious 0.999 0.00574 0.136 0.0192 NO NO ? +2.309 -0.962 -3.271 2 231 20 20 6q21 162 D 1.00 171 0.070 H A -49 0.77 -0.80 ? ? ? 3 2.753 ? ? ? ? ? ? PF00071.17 4.177 ? 79.89 +P01112 162 E T ? P01112 162 E T ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.569 -0.962 -3.531 2 231 20 20 6q21 162 D 1.00 171 0.070 H A -22 0.82 -0.80 ? ? ? 3 2.753 ? ? ? ? ? ? PF00071.17 2.825 ? 79.89 +P01112 162 E V ? P01112 162 E V A T probably damaging alignment ? deleterious 0.999 0.00574 0.136 0.0192 NO NO ? +2.672 -0.962 -3.634 2 231 20 20 6q21 162 D 1.00 171 0.070 H A 2 1.48 -0.80 ? ? ? 3 2.753 ? ? 1 1 0 -35 PF00071.17 2.450 ? 79.89 +P01112 162 E W ? P01112 162 E W ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +4.428 -0.962 -5.390 2 231 20 20 6q21 162 D 1.00 171 0.070 H A 89 1.51 -0.80 ? ? ? 3 2.753 ? ? ? ? ? ? PF00071.17 0.358 ? 79.89 +P01112 162 E Y ? P01112 162 E Y ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.328 -0.962 -4.290 2 231 20 20 6q21 162 D 1.00 171 0.070 H A 55 1.25 -0.80 ? ? ? 3 2.753 ? ? ? ? ? ? PF00071.17 0.892 ? 79.89 +P01112 163 I A ? P01112 163 I A ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.073 -1.004 -3.077 2 230 20 20 6q21 163 D 1.00 171 0.023 H A -79 0.48 -0.49 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 4.964 ? 71.43 +P01112 163 I C ? P01112 163 I C ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.682 -1.004 -4.686 2 230 20 20 6q21 163 D 1.00 171 0.023 H A -59 0.02 -0.49 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.333 ? 71.43 +P01112 163 I D ? P01112 163 I D ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.964 -1.004 -3.968 2 230 20 20 6q21 163 D 1.00 171 0.023 H A -56 1.23 -0.49 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.289 ? 71.43 +P01112 163 I E ? P01112 163 I E ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.885 -1.004 -3.889 2 230 20 20 6q21 163 D 1.00 171 0.023 H A -29 1.52 -0.49 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.664 ? 71.43 +P01112 163 I F ? P01112 163 I F A T probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.704 -1.004 -3.708 2 230 20 20 6q21 163 D 1.00 171 0.023 H A 23 0.1 -0.49 ? ? ? ? ? ? ? 1 0 0 -37 PF00071.17 2.524 ? 71.43 +P01112 163 I G ? P01112 163 I G ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.803 -1.004 -3.807 2 230 20 20 6q21 163 D 1.00 171 0.023 H A -107 0.77 -0.49 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.785 ? 71.43 +P01112 163 I H ? P01112 163 I H ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.950 -1.004 -4.954 2 230 20 20 6q21 163 D 1.00 171 0.023 H A -14 0.65 -0.49 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 0.636 ? 71.43 +P01112 163 I K ? P01112 163 I K ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.902 -1.004 -3.906 2 230 20 20 6q21 163 D 1.00 171 0.023 H A 1 2.82 -0.49 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.896 ? 71.43 +P01112 163 I L ? P01112 163 I L A C possibly damaging alignment ? deleterious 0.841 0.0682 0.836 0.0995 NO NO ? +1.545 -1.004 -2.549 2 230 20 20 6q21 163 D 1.00 171 0.023 H A 0 0.07 -0.49 ? ? ? ? ? ? ? 1 0 0 -37 PF00071.17 9.285 ? 71.43 +P01112 163 I M ? P01112 163 I M C G probably damaging alignment ? deleterious 0.999 0.00574 0.136 0.0192 NO NO ? +3.075 -1.004 -4.079 2 230 20 20 6q21 163 D 1.00 171 0.023 H A -4 0.07 -0.49 ? ? ? ? ? ? ? 1 2 0 -39 PF00071.17 2.265 ? 71.43 +P01112 163 I N ? P01112 163 I N T A probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.168 -1.004 -4.172 2 230 20 20 6q21 163 D 1.00 171 0.023 H A -53 1.09 -0.49 ? ? ? ? ? ? ? 1 1 0 -38 PF00071.17 1.177 ? 71.43 +P01112 163 I P ? P01112 163 I P ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.100 -1.004 -4.104 2 230 20 20 6q21 163 D 1.00 171 0.023 H A -55 1 -0.49 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.220 ? 71.43 +P01112 163 I Q ? P01112 163 I Q ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.344 -1.004 -4.348 2 230 20 20 6q21 163 D 1.00 171 0.023 H A -23 1.12 -0.49 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.142 ? 71.43 +P01112 163 I R ? P01112 163 I R ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +3.203 -1.004 -4.207 2 230 20 20 6q21 163 D 1.00 171 0.023 H A 6 1.68 -0.49 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.549 ? 71.43 +P01112 163 I S ? P01112 163 I S T G probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.656 -1.004 -3.660 2 230 20 20 6q21 163 D 1.00 171 0.023 H A -78 0.75 -0.49 ? ? ? ? ? ? ? 1 1 0 -38 PF00071.17 2.311 ? 71.43 +P01112 163 I T ? P01112 163 I T T C probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.416 -1.004 -3.420 2 230 20 20 6q21 163 D 1.00 171 0.023 H A -51 0.7 -0.49 ? ? ? ? ? ? ? 0 1 0 -38 PF00071.17 3.566 ? 71.43 +P01112 163 I V ? P01112 163 I V A G benign alignment ? neutral 0.384 0.106 0.897 0.138 NO NO ? +0.804 -1.004 -1.808 2 230 20 20 6q21 163 D 1.00 171 0.023 H A -27 0.04 -0.49 ? ? ? ? ? ? ? 0 0 0 -37 PF00071.17 19.231 19.231 71.43 +P01112 163 I W ? P01112 163 I W ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +4.368 -1.004 -5.372 2 230 20 20 6q21 163 D 1.00 171 0.023 H A 60 0.01 -0.49 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 0.349 ? 71.43 +P01112 163 I Y ? P01112 163 I Y ? ? probably damaging alignment ? deleterious 1 0.00026 0.00018 0.0109 NO NO ? +2.983 -1.004 -3.987 2 230 20 20 6q21 163 D 1.00 171 0.023 H A 26 0.27 -0.49 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 1.517 ? 71.43 +P01112 164 R A ? P01112 164 R A ? ? benign alignment ? neutral 0.341 0.11 0.9 0.142 NO NO ? +1.197 -1.502 -2.699 2 223 20 20 6q21 164 D 1.00 171 0.231 H A -85 1.2 0.19 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 16.399 16.399 84.13 +P01112 164 R C ? P01112 164 R C ? ? possibly damaging alignment ? deleterious 0.506 0.0965 0.883 0.129 NO NO ? +1.850 -1.502 -3.352 2 223 20 20 6q21 164 D 1.00 171 0.231 H A -65 1.66 0.19 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 20.968 20.968 84.13 +P01112 164 R D ? P01112 164 R D ? ? probably damaging alignment ? deleterious 0.962 0.0478 0.779 0.0767 NO NO ? +2.327 -1.502 -3.829 2 223 20 20 6q21 164 D 1.00 171 0.231 H A -62 0.45 0.19 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 3.226 ? 84.13 +P01112 164 R E ? P01112 164 R E ? ? possibly damaging alignment ? deleterious 0.793 0.0732 0.845 0.105 NO NO ? +1.936 -1.502 -3.438 2 223 20 20 6q21 164 D 1.00 171 0.231 H A -35 0.16 0.19 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 5.451 ? 84.13 +P01112 164 R F ? P01112 164 R F ? ? benign alignment ? neutral 0.104 0.144 0.928 0.174 NO NO ? +1.644 -1.502 -3.146 2 223 20 20 6q21 164 D 1.00 171 0.231 H A 17 1.78 0.19 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 27.533 27.533 84.13 +P01112 164 R G ? P01112 164 R G C G probably damaging alignment ? deleterious 0.98 0.0405 0.753 0.0679 NO NO ? +2.043 -1.502 -3.545 2 223 20 20 6q21 164 D 1.00 171 0.231 H A -113 0.91 0.19 ? ? ? ? ? ? ? 1 0 3 -40 PF00071.17 4.436 ? 84.13 +P01112 164 R H ? P01112 164 R H ? ? benign alignment ? neutral 0.108 0.143 0.928 0.173 NO NO ? +1.427 -1.502 -2.929 2 223 20 20 6q21 164 D 1.00 171 0.231 H A -20 1.03 0.19 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 29.784 29.784 84.13 +P01112 164 R I ? P01112 164 R I ? ? possibly damaging alignment ? deleterious 0.841 0.0682 0.836 0.0995 NO NO ? +2.444 -1.502 -3.946 2 223 20 20 6q21 164 D 1.00 171 0.231 H A -6 1.68 0.19 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 11.294 ? 84.13 +P01112 164 R K ? P01112 164 R K ? ? benign alignment ? neutral 0.003 0.556 0.981 0.39 NO NO ? +0.711 -1.502 -2.213 2 223 20 20 6q21 164 D 1.00 171 0.231 H A -5 1.14 0.19 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 21.257 21.257 84.13 +P01112 164 R L ? P01112 164 R L G T possibly damaging alignment ? deleterious 0.91 0.0609 0.814 0.092 NO NO ? +1.946 -1.502 -3.448 2 223 20 20 6q21 164 D 1.00 171 0.231 H A -6 1.75 0.19 ? ? ? ? ? ? ? 1 1 1 -41 PF00071.17 8.941 ? 84.13 +P01112 164 R M ? P01112 164 R M ? ? probably damaging alignment ? deleterious 0.988 0.0353 0.727 0.0617 NO NO ? +3.113 -1.502 -4.615 2 223 20 20 6q21 164 D 1.00 171 0.231 H A -10 1.75 0.19 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 2.181 ? 84.13 +P01112 164 R N ? P01112 164 R N ? ? possibly damaging alignment ? deleterious 0.927 0.0581 0.807 0.0889 NO NO ? +2.255 -1.502 -3.757 2 223 20 20 6q21 164 D 1.00 171 0.231 H A -59 0.59 0.19 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 4.590 ? 84.13 +P01112 164 R P ? P01112 164 R P G C probably damaging alignment ? deleterious 0.99 0.0338 0.719 0.06 NO NO ? +2.543 -1.502 -4.045 2 223 20 20 6q21 164 D 1.00 171 0.231 H A -61 0.68 0.19 ? ? ? ? ? ? ? 1 1 3 -41 PF00071.17 2.081 ? 84.13 +P01112 164 R Q ? P01112 164 R Q G A possibly damaging alignment ? deleterious 0.825 0.0696 0.838 0.101 NO NO ? +1.259 -1.502 -2.761 2 223 20 20 6q21 164 D 1.00 171 0.231 H A -29 0.56 0.19 ? ? ? ? ? ? ? 0 1 1 -41 PF00071.17 9.168 9.168 84.13 +P01112 164 R S ? P01112 164 R S ? ? possibly damaging alignment ? deleterious 0.927 0.0581 0.807 0.0889 NO NO ? +2.023 -1.502 -3.525 2 223 20 20 6q21 164 D 1.00 171 0.231 H A -84 0.93 0.19 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 4.770 ? 84.13 +P01112 164 R T ? P01112 164 R T ? ? probably damaging alignment ? deleterious 0.962 0.0478 0.779 0.0767 NO NO ? +2.116 -1.502 -3.618 2 223 20 20 6q21 164 D 1.00 171 0.231 H A -57 0.98 0.19 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 3.434 ? 84.13 +P01112 164 R V ? P01112 164 R V ? ? benign alignment ? neutral 0.273 0.116 0.908 0.148 NO NO ? +1.447 -1.502 -2.949 2 223 20 20 6q21 164 D 1.00 171 0.231 H A -33 1.64 0.19 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 18.518 18.518 84.13 +P01112 164 R W ? P01112 164 R W C T possibly damaging alignment ? deleterious 0.866 0.0661 0.829 0.0975 NO NO ? +1.850 -1.502 -3.352 2 223 20 20 6q21 164 D 1.00 171 0.231 H A 54 1.67 0.19 ? ? ? ? ? ? ? 0 0 1 -40 PF00071.17 22.331 22.331 84.13 +P01112 164 R Y ? P01112 164 R Y ? ? possibly damaging alignment ? deleterious 0.836 0.0687 0.836 0.1 NO NO ? +2.535 -1.502 -4.037 2 223 20 20 6q21 164 D 1.00 171 0.231 H A 20 1.41 0.19 ? ? ? ? ? ? ? ? ? ? ? PF00071.17 6.386 ? 84.13 +P01112 165 Q A ? P01112 165 Q A ? ? benign alignment ? neutral 0 1 1 0.575 NO NO ? +0.297 -2.433 -2.730 2 222 20 20 6q21 165 D 1.00 171 0.331 H A -56 0.64 0.59 ? ? ? 4 3.223 ? ? ? ? ? ? PF00071.17 22.836 22.836 85.19 +P01112 165 Q C ? P01112 165 Q C ? ? benign alignment ? neutral 0.379 0.107 0.897 0.139 NO NO ? +2.741 -2.433 -5.174 2 222 20 20 6q21 165 D 1.00 171 0.331 H A -36 1.1 0.59 ? ? ? 4 3.223 ? ? ? ? ? ? PF00071.17 1.689 ? 85.19 +P01112 165 Q D ? P01112 165 Q D ? ? benign alignment ? neutral 0.017 0.205 0.954 0.225 NO NO ? +1.203 -2.433 -3.636 2 222 20 20 6q21 165 D 1.00 171 0.331 H A -33 0.11 0.59 ? ? ? 4 3.223 ? ? ? ? ? ? PF00071.17 5.379 ? 85.19 +P01112 165 Q E ? P01112 165 Q E C G benign alignment ? neutral 0.001 0.852 0.994 0.514 NO NO ? +0.339 -2.433 -2.772 2 222 20 20 6q21 165 D 1.00 171 0.331 H A -6 0.4 0.59 ? ? ? 4 3.223 ? ? 1 0 0 -43 PF00071.17 14.774 14.774 85.19 +P01112 165 Q F ? P01112 165 Q F ? ? benign alignment ? neutral 0.218 0.122 0.914 0.153 NO NO ? +1.922 -2.433 -4.355 2 222 20 20 6q21 165 D 1.00 171 0.331 H A 46 1.22 0.59 ? ? ? 4 3.223 ? ? ? ? ? ? PF00071.17 4.664 ? 85.19 +P01112 165 Q G ? P01112 165 Q G ? ? benign alignment ? neutral 0.056 0.163 0.939 0.19 NO NO ? +1.061 -2.433 -3.494 2 222 20 20 6q21 165 D 1.00 171 0.331 H A -84 0.35 0.59 ? ? ? 4 3.223 ? ? ? ? ? ? PF00071.17 6.178 ? 85.19 +P01112 165 Q H ? P01112 165 Q H G C benign alignment ? neutral 0.001 0.852 0.994 0.514 NO NO ? +0.856 -2.433 -3.289 2 222 20 20 6q21 165 D 1.00 171 0.331 H A 9 0.47 0.59 ? ? ? 4 3.223 ? ? 1 2 0 -45 PF00071.17 29.596 29.596 85.19 +P01112 165 Q I ? P01112 165 Q I ? ? benign alignment ? neutral 0.054 0.164 0.94 0.191 NO NO ? +1.581 -2.433 -4.014 2 222 20 20 6q21 165 D 1.00 171 0.331 H A 23 1.12 0.59 ? ? ? 4 3.223 ? ? ? ? ? ? PF00071.17 9.803 ? 85.19 +P01112 165 Q K ? P01112 165 Q K C A benign alignment ? neutral 0 1 1 0.575 NO NO ? -0.670 -2.433 -1.763 2 222 20 20 6q21 165 D 1.00 171 0.331 H A 24 1.7 0.59 ? ? ? 4 3.223 ? ? 1 0 0 -43 PF00071.17 23.016 23.016 85.19 +P01112 165 Q L ? P01112 165 Q L A T benign alignment ? neutral 0 1 1 0.575 NO NO ? +0.421 -2.433 -2.854 2 222 20 20 6q21 165 D 1.00 171 0.331 H A 23 1.19 0.59 ? ? ? 4 3.223 ? ? 1 1 0 -44 PF00071.17 31.988 31.988 85.19 +P01112 165 Q M ? P01112 165 Q M ? ? benign alignment ? neutral 0.01 0.226 0.96 0.242 NO NO ? +0.930 -2.433 -3.363 2 222 20 20 6q21 165 D 1.00 171 0.331 H A 19 1.19 0.59 ? ? ? 4 3.223 ? ? ? ? ? ? PF00071.17 12.941 12.941 85.19 +P01112 165 Q N ? P01112 165 Q N ? ? benign alignment ? neutral 0 1 1 0.575 NO NO ? +0.284 -2.433 -2.717 2 222 20 20 6q21 165 D 1.00 171 0.331 H A -30 0.0299999999999999 0.59 ? ? ? 4 3.223 ? ? ? ? ? ? PF00071.17 20.444 20.444 85.19 +P01112 165 Q P ? P01112 165 Q P A C benign alignment ? neutral 0.116 0.142 0.927 0.172 NO NO ? +1.535 -2.433 -3.968 2 222 20 20 6q21 165 D 1.00 171 0.331 H A -32 0.12 0.59 ? ? ? 4 3.223 ? ? 1 1 2 -44 PF00071.17 2.295 ? 85.19 +P01112 165 Q R ? P01112 165 Q R A G benign alignment ? neutral 0 1 1 0.575 NO NO ? -0.458 -2.433 -1.975 2 222 20 20 6q21 165 D 1.00 171 0.331 H A 29 0.56 0.59 ? ? ? 4 3.223 ? ? 0 1 2 -44 PF00071.17 27.851 27.851 85.19 +P01112 165 Q S ? P01112 165 Q S ? ? benign alignment ? neutral 0.004 0.408 0.975 0.328 NO NO ? +0.398 -2.433 -2.831 2 222 20 20 6q21 165 D 1.00 171 0.331 H A -55 0.37 0.59 ? ? ? 4 3.223 ? ? ? ? ? ? PF00071.17 17.338 17.338 85.19 +P01112 165 Q T ? P01112 165 Q T ? ? benign alignment ? neutral 0.002 0.704 0.987 0.452 NO NO ? +1.146 -2.433 -3.579 2 222 20 20 6q21 165 D 1.00 171 0.331 H A -28 0.42 0.59 ? ? ? 4 3.223 ? ? ? ? ? ? PF00071.17 6.475 ? 85.19 +P01112 165 Q V ? P01112 165 Q V ? ? benign alignment ? neutral 0.007 0.246 0.965 0.257 NO NO ? +1.246 -2.433 -3.679 2 222 20 20 6q21 165 D 1.00 171 0.331 H A -4 1.08 0.59 ? ? ? 4 3.223 ? ? ? ? ? ? PF00071.17 8.164 ? 85.19 +P01112 165 Q W ? P01112 165 Q W ? ? probably damaging alignment ? deleterious 0.972 0.0442 0.766 0.0725 NO NO ? +3.027 -2.433 -5.460 2 222 20 20 6q21 165 D 1.00 171 0.331 H A 83 1.11 0.59 ? ? ? 4 3.223 ? ? ? ? ? ? PF00071.17 0.635 ? 85.19 +P01112 165 Q Y ? P01112 165 Q Y ? ? benign alignment ? neutral 0.074 0.155 0.934 0.184 NO NO ? +1.811 -2.433 -4.244 2 222 20 20 6q21 165 D 1.00 171 0.331 H A 49 0.85 0.59 ? ? ? 4 3.223 ? ? ? ? ? ? PF00071.17 4.852 ? 85.19 +P01112 166 H A ? P01112 166 H A ? ? benign alignment ? neutral 0.001 0.852 0.994 0.514 NO NO ? +0.128 -2.780 -2.908 2 196 20 20 6q21 166 D 1.00 171 0.429 H A -65 0.17 0.28 ? ? ? ? ? ? ? ? ? ? ? NO 15.633 15.633 86.24 +P01112 166 H C ? P01112 166 H C ? ? benign alignment ? neutral 0.403 0.105 0.894 0.137 NO NO ? +2.366 -2.780 -5.146 2 196 20 20 6q21 166 D 1.00 171 0.429 H A -45 0.63 0.28 ? ? ? ? ? ? ? ? ? ? ? NO 1.272 ? 86.24 +P01112 166 H D ? P01112 166 H D C G benign alignment ? neutral 0 1 1 0.575 NO NO ? -0.207 -2.780 -2.573 2 196 20 20 6q21 166 D 1.00 171 0.429 H A -42 0.58 0.28 ? ? ? ? ? ? ? 1 0 0 -46 NO 31.696 31.696 86.24 +P01112 166 H E ? P01112 166 H E ? ? benign alignment ? neutral 0 1 1 0.575 NO NO ? +0.074 -2.780 -2.854 2 196 20 20 6q21 166 D 1.00 171 0.429 H A -15 0.87 0.28 ? ? ? ? ? ? ? ? ? ? ? NO 18.861 18.861 86.24 +P01112 166 H F ? P01112 166 H F ? ? benign alignment ? neutral 0 1 1 0.575 NO NO ? +0.019 -2.780 -2.799 2 196 20 20 6q21 166 D 1.00 171 0.429 H A 37 0.75 0.28 ? ? ? ? ? ? ? ? ? ? ? NO 32.019 32.019 86.24 +P01112 166 H G ? P01112 166 H G ? ? benign alignment ? neutral 0 1 1 0.575 NO NO ? +0.226 -2.780 -3.006 2 196 20 20 6q21 166 D 1.00 171 0.429 H A -93 0.12 0.28 ? ? ? ? ? ? ? ? ? ? ? NO 25.088 25.088 86.24 +P01112 166 H I ? P01112 166 H I ? ? benign alignment ? neutral 0 1 1 0.575 NO NO ? -0.005 -2.780 -2.775 2 196 20 20 6q21 166 D 1.00 171 0.429 H A 14 0.65 0.28 ? ? ? ? ? ? ? ? ? ? ? NO 21.406 21.406 86.24 +P01112 166 H K ? P01112 166 H K ? ? benign alignment ? neutral 0.001 0.852 0.994 0.514 NO NO ? +0.331 -2.780 -3.111 2 196 20 20 6q21 166 D 1.00 171 0.429 H A 15 2.17 0.28 ? ? ? ? ? ? ? ? ? ? ? NO 12.461 12.461 86.24 +P01112 166 H L ? P01112 166 H L A T benign alignment ? neutral 0 1 1 0.575 NO NO ? +0.128 -2.780 -2.908 2 196 20 20 6q21 166 D 1.00 171 0.429 H A 14 0.72 0.28 ? ? ? ? ? ? ? 1 1 0 -47 NO 26.823 26.823 86.24 +P01112 166 H M ? P01112 166 H M ? ? benign alignment ? neutral 0.002 0.704 0.987 0.452 NO NO ? +0.466 -2.780 -3.246 2 196 20 20 6q21 166 D 1.00 171 0.429 H A 10 0.72 0.28 ? ? ? ? ? ? ? ? ? ? ? NO 10.455 10.455 86.24 +P01112 166 H N ? P01112 166 H N C A benign alignment ? neutral 0.005 0.26 0.968 0.267 NO NO ? +1.157 -2.780 -3.937 2 196 20 20 6q21 166 D 1.00 171 0.429 H A -39 0.44 0.28 ? ? ? ? ? ? ? 1 0 0 -46 NO 5.542 ? 86.24 +P01112 166 H P ? P01112 166 H P A C benign alignment ? neutral 0.046 0.169 0.942 0.195 NO NO ? +1.408 -2.780 -4.188 2 196 20 20 6q21 166 D 1.00 171 0.429 H A -41 0.35 0.28 ? ? ? ? ? ? ? 1 1 0 -47 NO 1.843 ? 86.24 +P01112 166 H Q ? P01112 166 H Q C G benign alignment ? neutral 0 1 1 0.575 NO NO ? +0.516 -2.780 -3.296 2 196 20 20 6q21 166 D 1.00 171 0.429 H A -9 0.47 0.28 ? ? ? ? ? ? ? 1 2 0 -48 NO 14.715 14.715 86.24 +P01112 166 H R ? P01112 166 H R A G benign alignment ? neutral 0 1 1 0.575 NO NO ? +0.485 -2.780 -3.265 2 196 20 20 6q21 166 D 1.00 171 0.429 H A 20 1.03 0.28 ? ? ? ? ? ? ? 0 1 2 -47 NO 23.482 23.482 86.24 +P01112 166 H S ? P01112 166 H S ? ? benign alignment ? neutral 0.002 0.704 0.987 0.452 NO NO ? +0.092 -2.780 -2.872 2 196 20 20 6q21 166 D 1.00 171 0.429 H A -64 0.1 0.28 ? ? ? ? ? ? ? ? ? ? ? NO 12.102 12.102 86.24 +P01112 166 H T ? P01112 166 H T ? ? benign alignment ? neutral 0.003 0.556 0.981 0.39 NO NO ? +0.954 -2.780 -3.734 2 196 20 20 6q21 166 D 1.00 171 0.429 H A -37 0.05 0.28 ? ? ? ? ? ? ? ? ? ? ? NO 4.520 ? 86.24 +P01112 166 H V ? P01112 166 H V ? ? benign alignment ? neutral 0 1 1 0.575 NO NO ? +0.039 -2.780 -2.819 2 196 20 20 6q21 166 D 1.00 171 0.429 H A -13 0.61 0.28 ? ? ? ? ? ? ? ? ? ? ? NO 13.897 13.675 86.24 +P01112 166 H W ? P01112 166 H W ? ? benign alignment ? neutral 0 1 1 0.575 NO NO ? +0.227 -2.780 -3.007 2 196 20 20 6q21 166 D 1.00 171 0.429 H A 74 0.64 0.28 ? ? ? ? ? ? ? ? ? ? ? NO 36.256 36.256 86.24 +P01112 166 H Y ? P01112 166 H Y C T benign alignment ? neutral 0 1 1 0.575 NO NO ? -0.314 -2.780 -2.466 2 196 20 20 6q21 166 D 1.00 171 0.429 H A 40 0.38 0.28 ? ? ? ? ? ? ? 0 0 0 -46 NO 27.374 27.374 86.24 +P01112 167 K A ? P01112 167 K A ? ? benign alignment ? neutral 0.203 0.125 0.915 0.156 NO NO ? +1.494 -1.737 -3.231 2 181 20 10 6q21 167 D 1.00 171 0.452 H A -80 2.34 0.69 ? ? ? ? ? ? ? ? ? ? ? NO 5.549 ? 86.24 +P01112 167 K C ? P01112 167 K C ? ? benign alignment ? neutral 0.02 0.198 0.952 0.22 NO NO ? +1.651 -1.737 -3.388 2 181 20 10 6q21 167 D 1.00 171 0.452 H A -60 2.8 0.69 ? ? ? ? ? ? ? ? ? ? ? NO 34.521 34.521 86.24 +P01112 167 K D ? P01112 167 K D ? ? possibly damaging alignment ? neutral 0.472 0.0988 0.887 0.131 NO NO ? +1.883 -1.737 -3.620 2 181 20 10 6q21 167 D 1.00 171 0.452 H A -57 1.59 0.69 ? ? ? ? ? ? ? ? ? ? ? NO 7.135 ? 86.24 +P01112 167 K E ? P01112 167 K E A G benign alignment ? neutral 0.002 0.704 0.987 0.452 NO NO ? +1.031 -1.737 -2.768 2 181 20 10 6q21 167 D 1.00 171 0.452 H A -30 1.3 0.69 ? ? ? ? ? ? ? 0 0 2 -49 NO 23.419 23.419 86.24 +P01112 167 K F ? P01112 167 K F ? ? benign alignment ? neutral 0.415 0.103 0.893 0.135 NO NO ? +2.653 -1.737 -4.390 2 181 20 10 6q21 167 D 1.00 171 0.452 H A 22 2.92 0.69 ? ? ? ? ? ? ? ? ? ? ? NO 3.650 ? 86.24 +P01112 167 K G ? P01112 167 K G ? ? benign alignment ? neutral 0.337 0.111 0.901 0.142 NO NO ? +1.766 -1.737 -3.503 2 181 20 10 6q21 167 D 1.00 171 0.452 H A -108 2.05 0.69 ? ? ? ? ? ? ? ? ? ? ? NO 3.403 ? 86.24 +P01112 167 K H ? P01112 167 K H ? ? possibly damaging alignment ? deleterious 0.85 0.0674 0.834 0.0987 NO NO ? +2.837 -1.737 -4.574 2 181 20 10 6q21 167 D 1.00 171 0.452 H A -15 2.17 0.69 ? ? ? ? ? ? ? ? ? ? ? NO 2.073 ? 86.24 +P01112 167 K I ? P01112 167 K I ? ? benign alignment ? neutral 0.026 0.188 0.949 0.211 NO NO ? +2.269 -1.737 -4.006 2 181 20 10 6q21 167 D 1.00 171 0.452 H A -1 2.82 0.69 ? ? ? ? ? ? ? ? ? ? ? NO 7.672 ? 86.24 +P01112 167 K L ? P01112 167 K L ? ? benign alignment ? neutral 0 1 1 0.575 NO NO ? +0.905 -1.737 -2.642 2 181 20 10 6q21 167 D 1.00 171 0.452 H A -1 2.89 0.69 ? ? ? ? ? ? ? ? ? ? ? NO 25.034 25.034 86.24 +P01112 167 K M ? P01112 167 K M A T benign alignment ? neutral 0.378 0.107 0.897 0.139 NO NO ? +2.873 -1.737 -4.610 2 181 20 10 6q21 167 D 1.00 171 0.452 H A -5 2.89 0.69 ? ? ? ? ? ? ? 1 1 0 -50 NO 3.323 ? 86.24 +P01112 167 K N ? P01112 167 K N G C benign alignment ? neutral 0.012 0.219 0.958 0.236 NO NO ? +0.963 -1.737 -2.700 2 181 20 10 6q21 167 D 1.00 171 0.452 H A -54 1.73 0.69 ? ? ? ? ? ? ? 1 2 0 -51 NO 15.920 15.920 86.24 +P01112 167 K P ? P01112 167 K P ? ? benign alignment ? neutral 0.008 0.239 0.963 0.252 NO NO ? +1.273 -1.737 -3.010 2 181 20 10 6q21 167 D 1.00 171 0.452 H A -56 1.82 0.69 ? ? ? ? ? ? ? ? ? ? ? NO 39.003 39.003 86.24 +P01112 167 K Q ? P01112 167 K Q A C benign alignment ? neutral 0.001 0.852 0.994 0.514 NO NO ? +0.837 -1.737 -2.574 2 181 20 10 6q21 167 D 1.00 171 0.452 H A -24 1.7 0.69 ? ? ? ? ? ? ? 1 0 0 -49 NO 13.923 13.923 86.24 +P01112 167 K R ? P01112 167 K R A G benign alignment ? neutral 0 1 1 0.575 NO NO ? +0.293 -1.737 -2.030 2 181 20 10 6q21 167 D 1.00 171 0.452 H A 5 1.14 0.69 ? ? ? ? ? ? ? 0 1 0 -50 NO 29.671 29.671 86.24 +P01112 167 K S ? P01112 167 K S ? ? benign alignment ? neutral 0.044 0.17 0.942 0.197 NO NO ? +0.878 -1.737 -2.615 2 181 20 10 6q21 167 D 1.00 171 0.452 H A -79 2.07 0.69 ? ? ? ? ? ? ? ? ? ? ? NO 11.171 11.171 86.24 +P01112 167 K T ? P01112 167 K T A C benign alignment ? neutral 0.103 0.144 0.929 0.174 NO NO ? +1.815 -1.737 -3.552 2 181 20 10 6q21 167 D 1.00 171 0.452 H A -52 2.12 0.69 ? ? ? ? ? ? ? 1 1 2 -50 NO 4.172 ? 86.24 +P01112 167 K V ? P01112 167 K V ? ? benign alignment ? neutral 0.033 0.179 0.946 0.204 NO NO ? +1.954 -1.737 -3.691 2 181 20 10 6q21 167 D 1.00 171 0.452 H A -28 2.78 0.69 ? ? ? ? ? ? ? ? ? ? ? NO 6.389 ? 86.24 +P01112 167 K W ? P01112 167 K W ? ? probably damaging alignment ? deleterious 0.984 0.0381 0.743 0.065 NO NO ? +3.747 -1.737 -5.484 2 181 20 10 6q21 167 D 1.00 171 0.452 H A 59 2.81 0.69 ? ? ? ? ? ? ? ? ? ? ? NO 0.493 ? 86.24 +P01112 167 K Y ? P01112 167 K Y ? ? benign alignment ? neutral 0.339 0.11 0.901 0.142 NO NO ? +2.585 -1.737 -4.322 2 181 20 10 6q21 167 D 1.00 171 0.452 H A 25 2.55 0.69 ? ? ? ? ? ? ? ? ? ? ? NO 1.548 ? 86.24 +P01112 168 L A ? P01112 168 L A ? ? benign alignment ? neutral 0 1 1 0.575 NO NO ? +0.086 -2.309 -2.395 2 129 20 8 6q21 168 D 1.00 171 0.956 T A -79 0.55 0.75 ? ? ? ? ? ? ? ? ? ? ? NO 23.142 23.142 94.18 +P01112 168 L C ? P01112 168 L C ? ? benign alignment ? neutral 0.109 0.143 0.928 0.173 NO NO ? +2.714 -2.309 -5.023 2 129 20 8 6q21 168 D 1.00 171 0.956 T A -59 0.09 0.75 ? ? ? ? ? ? ? ? ? ? ? NO 1.712 ? 94.18 +P01112 168 L D ? P01112 168 L D ? ? benign alignment ? neutral 0 1 1 0.575 NO NO ? +0.442 -2.309 -2.751 2 129 20 8 6q21 168 D 1.00 171 0.956 T A -56 1.3 0.75 ? ? ? ? ? ? ? ? ? ? ? NO 33.375 33.375 94.18 +P01112 168 L E ? P01112 168 L E ? ? benign alignment ? neutral 0 1 1 0.575 NO NO ? +0.225 -2.309 -2.534 2 129 20 8 6q21 168 D 1.00 171 0.956 T A -29 1.59 0.75 ? ? ? ? ? ? ? ? ? ? ? NO 24.205 24.205 94.18 +P01112 168 L F ? P01112 168 L F ? ? benign alignment ? neutral 0.023 0.193 0.95 0.216 NO NO ? +1.911 -2.309 -4.220 2 129 20 8 6q21 168 D 1.00 171 0.956 T A 23 0.03 0.75 ? ? ? ? ? ? ? ? ? ? ? NO 4.485 ? 94.18 +P01112 168 L G ? P01112 168 L G ? ? benign alignment ? neutral 0 1 1 0.575 NO NO ? +0.330 -2.309 -2.639 2 129 20 8 6q21 168 D 1.00 171 0.956 T A -107 0.84 0.75 ? ? ? ? ? ? ? ? ? ? ? NO 22.930 22.930 94.18 +P01112 168 L H ? P01112 168 L H ? ? benign alignment ? neutral 0.048 0.167 0.941 0.194 NO NO ? +2.481 -2.309 -4.790 2 129 20 8 6q21 168 D 1.00 171 0.956 T A -14 0.72 0.75 ? ? ? ? ? ? ? ? ? ? ? NO 2.051 ? 94.18 +P01112 168 L I ? P01112 168 L I ? ? benign alignment ? neutral 0 1 1 0.575 NO NO ? +0.704 -2.309 -3.013 2 129 20 8 6q21 168 D 1.00 171 0.956 T A 0 0.07 0.75 ? ? ? ? ? ? ? ? ? ? ? NO 18.533 18.533 94.18 +P01112 168 L K ? P01112 168 L K ? ? benign alignment ? neutral 0 1 1 0.575 NO NO ? +0.414 -2.309 -2.723 2 129 20 8 6q21 168 D 1.00 171 0.956 T A 1 2.89 0.75 ? ? ? ? ? ? ? ? ? ? ? NO 19.644 19.644 94.18 +P01112 168 L M ? P01112 168 L M C A benign alignment ? neutral 0 1 1 0.575 NO NO ? +0.556 -2.309 -2.865 2 129 20 8 6q21 168 D 1.00 171 0.956 T A -4 0 0.75 ? ? ? ? ? ? ? 1 0 0 -52 NO 15.255 15.255 94.18 +P01112 168 L N ? P01112 168 L N ? ? benign alignment ? neutral 0.009 0.233 0.961 0.247 NO NO ? +1.532 -2.309 -3.841 2 129 20 8 6q21 168 D 1.00 171 0.956 T A -53 1.16 0.75 ? ? ? ? ? ? ? ? ? ? ? NO 5.836 ? 94.18 +P01112 168 L P ? P01112 168 L P T C benign alignment ? neutral 0.026 0.188 0.949 0.211 NO NO ? +1.702 -2.309 -4.011 2 129 20 8 6q21 168 D 1.00 171 0.956 T A -55 1.07 0.75 ? ? ? ? ? ? ? 0 1 2 -53 NO 2.322 ? 94.18 +P01112 168 L Q ? P01112 168 L Q T A benign alignment ? neutral 0 1 1 0.575 NO NO ? +0.590 -2.309 -2.899 2 129 20 8 6q21 168 D 1.00 171 0.956 T A -23 1.19 0.75 ? ? ? ? ? ? ? 1 1 0 -53 NO 11.546 11.546 94.18 +P01112 168 L R ? P01112 168 L R T G benign alignment ? neutral 0 1 1 0.575 NO NO ? +0.791 -2.309 -3.100 2 129 20 8 6q21 168 D 1.00 171 0.956 T A 6 1.75 0.75 ? ? ? ? ? ? ? 1 1 2 -53 NO 27.123 27.123 94.18 +P01112 168 L S ? P01112 168 L S ? ? benign alignment ? neutral 0.001 0.852 0.994 0.514 NO NO ? +0.379 -2.309 -2.688 2 129 20 8 6q21 168 D 1.00 171 0.956 T A -78 0.82 0.75 ? ? ? ? ? ? ? ? ? ? ? NO 10.123 10.123 94.18 +P01112 168 L T ? P01112 168 L T ? ? benign alignment ? neutral 0 1 1 0.575 NO NO ? +0.405 -2.309 -2.714 2 129 20 8 6q21 168 D 1.00 171 0.956 T A -51 0.77 0.75 ? ? ? ? ? ? ? ? ? ? ? NO 18.346 18.346 94.18 +P01112 168 L V ? P01112 168 L V C G benign alignment ? neutral 0 1 1 0.575 NO NO ? +0.353 -2.309 -2.662 2 129 20 8 6q21 168 D 1.00 171 0.956 T A -27 0.11 0.75 ? ? ? ? ? ? ? 1 0 0 -52 NO 22.649 22.649 94.18 +P01112 168 L W ? P01112 168 L W ? ? possibly damaging alignment ? deleterious 0.676 0.0848 0.862 0.118 NO NO ? +3.127 -2.309 -5.436 2 129 20 8 6q21 168 D 1.00 171 0.956 T A 60 0.08 0.75 ? ? ? ? ? ? ? ? ? ? ? NO 0.749 ? 94.18 +P01112 168 L Y ? P01112 168 L Y ? ? benign alignment ? neutral 0.006 0.253 0.967 0.262 NO NO ? +2.013 -2.309 -4.322 2 129 20 8 6q21 168 D 1.00 171 0.956 T A 26 0.34 0.75 ? ? ? ? ? ? ? ? ? ? ? NO 2.154 ? 94.18 +P01112 169 R A ? P01112 169 R A ? ? benign alignment ? neutral 0.032 0.18 0.946 0.205 NO NO ? +1.022 -2.240 -3.262 2 127 20 8 6q21 169 D 1.00 171 0.744 T A -85 1.2 1.18 ? ? ? ? ? ? ? ? ? ? ? NO 9.307 ? 86.24 +P01112 169 R C ? P01112 169 R C ? ? possibly damaging alignment ? deleterious 0.928 0.058 0.806 0.0888 NO NO ? +2.964 -2.240 -5.204 2 127 20 8 6q21 169 D 1.00 171 0.744 T A -65 1.66 1.18 ? ? ? ? ? ? ? ? ? ? ? NO 1.553 ? 86.24 +P01112 169 R D ? P01112 169 R D ? ? benign alignment ? neutral 0 1 1 0.575 NO NO ? +0.394 -2.240 -2.634 2 127 20 8 6q21 169 D 1.00 171 0.744 T A -62 0.45 1.18 ? ? ? ? ? ? ? ? ? ? ? NO 27.078 27.078 86.24 +P01112 169 R E ? P01112 169 R E ? ? benign alignment ? neutral 0 1 1 0.575 NO NO ? +0.179 -2.240 -2.419 2 127 20 8 6q21 169 D 1.00 171 0.744 T A -35 0.16 1.18 ? ? ? ? ? ? ? ? ? ? ? NO 21.376 21.376 86.24 +P01112 169 R F ? P01112 169 R F ? ? benign alignment ? neutral 0.002 0.704 0.987 0.452 NO NO ? +0.992 -2.240 -3.232 2 127 20 8 6q21 169 D 1.00 171 0.744 T A 17 1.78 1.18 ? ? ? ? ? ? ? ? ? ? ? NO 17.335 17.335 86.24 +P01112 169 R G ? P01112 169 R G C G benign alignment ? neutral 0.001 0.852 0.994 0.514 NO NO ? +0.541 -2.240 -2.781 2 127 20 8 6q21 169 D 1.00 171 0.744 T A -113 0.91 1.18 ? ? ? ? ? ? ? 1 0 1 -55 NO 33.990 33.990 86.24 +P01112 169 R H ? P01112 169 R H ? ? benign alignment ? neutral 0.187 0.127 0.917 0.158 NO NO ? +2.316 -2.240 -4.556 2 127 20 8 6q21 169 D 1.00 171 0.744 T A -20 1.03 1.18 ? ? ? ? ? ? ? ? ? ? ? NO 2.746 ? 86.24 +P01112 169 R I ? P01112 169 R I ? ? benign alignment ? neutral 0.006 0.253 0.967 0.262 NO NO ? +0.916 -2.240 -3.156 2 127 20 8 6q21 169 D 1.00 171 0.744 T A -6 1.68 1.18 ? ? ? ? ? ? ? ? ? ? ? NO 12.212 12.212 86.24 +P01112 169 R K ? P01112 169 R K ? ? benign alignment ? neutral 0 1 1 0.575 NO NO ? -0.100 -2.240 -2.140 2 127 20 8 6q21 169 D 1.00 171 0.744 T A -5 1.14 1.18 ? ? ? ? ? ? ? ? ? ? ? NO 23.896 23.896 86.24 +P01112 169 R L ? P01112 169 R L G T benign alignment ? neutral 0.025 0.189 0.949 0.213 NO NO ? +1.297 -2.240 -3.537 2 127 20 8 6q21 169 D 1.00 171 0.744 T A -6 1.75 1.18 ? ? ? ? ? ? ? 1 1 1 -56 NO 7.537 ? 86.24 +P01112 169 R M ? P01112 169 R M ? ? benign alignment ? neutral 0.318 0.112 0.903 0.143 NO NO ? +2.468 -2.240 -4.708 2 127 20 8 6q21 169 D 1.00 171 0.744 T A -10 1.75 1.18 ? ? ? ? ? ? ? ? ? ? ? NO 1.703 ? 86.24 +P01112 169 R N ? P01112 169 R N ? ? benign alignment ? neutral 0 1 1 0.575 NO NO ? +0.280 -2.240 -2.520 2 127 20 8 6q21 169 D 1.00 171 0.744 T A -59 0.59 1.18 ? ? ? ? ? ? ? ? ? ? ? NO 27.148 27.148 86.24 +P01112 169 R P ? P01112 169 R P G C benign alignment ? neutral 0.38 0.106 0.897 0.139 NO NO ? +1.737 -2.240 -3.977 2 127 20 8 6q21 169 D 1.00 171 0.744 T A -61 0.68 1.18 ? ? ? ? ? ? ? 1 1 3 -56 NO 2.480 ? 86.24 +P01112 169 R Q ? P01112 169 R Q G A benign alignment ? neutral 0.007 0.246 0.965 0.257 NO NO ? +0.369 -2.240 -2.609 2 127 20 8 6q21 169 D 1.00 171 0.744 T A -29 0.56 1.18 ? ? ? ? ? ? ? 0 1 1 -56 NO 16.866 16.866 86.24 +P01112 169 R S ? P01112 169 R S ? ? benign alignment ? neutral 0.002 0.704 0.987 0.452 NO NO ? +0.381 -2.240 -2.621 2 127 20 8 6q21 169 D 1.00 171 0.744 T A -84 0.93 1.18 ? ? ? ? ? ? ? ? ? ? ? NO 18.734 18.734 86.24 +P01112 169 R T ? P01112 169 R T ? ? benign alignment ? neutral 0 1 1 0.575 NO NO ? +0.653 -2.240 -2.893 2 127 20 8 6q21 169 D 1.00 171 0.744 T A -57 0.98 1.18 ? ? ? ? ? ? ? ? ? ? ? NO 19.907 19.907 86.24 +P01112 169 R V ? P01112 169 R V ? ? benign alignment ? neutral 0.023 0.193 0.95 0.216 NO NO ? +1.428 -2.240 -3.668 2 127 20 8 6q21 169 D 1.00 171 0.744 T A -33 1.64 1.18 ? ? ? ? ? ? ? ? ? ? ? NO 7.928 ? 86.24 +P01112 169 R W ? P01112 169 R W C T probably damaging alignment ? deleterious 0.988 0.0353 0.727 0.0617 NO NO ? +3.202 -2.240 -5.442 2 127 20 8 6q21 169 D 1.00 171 0.744 T A 54 1.67 1.18 ? ? ? ? ? ? ? 0 0 1 -55 NO 0.805 ? 86.24 +P01112 169 R Y ? P01112 169 R Y ? ? benign alignment ? neutral 0.181 0.129 0.918 0.16 NO NO ? +2.016 -2.240 -4.256 2 127 20 8 6q21 169 D 1.00 171 0.744 T A 20 1.41 1.18 ? ? ? ? ? ? ? ? ? ? ? NO 4.021 ? 86.24 +P01112 170 K A ? P01112 170 K A ? ? benign alignment ? neutral 0.053 0.164 0.94 0.191 NO NO ? +1.227 -2.023 -3.250 2 118 20 7 6q21 170 D 1.00 171 0.685 . B -80 2.34 1.85 ? ? ? ? ? ? ? ? ? ? ? NO 8.613 ? 84.13 +P01112 170 K C ? P01112 170 K C ? ? probably damaging alignment ? deleterious 0.957 0.0496 0.784 0.079 NO NO ? +3.164 -2.023 -5.187 2 118 20 7 6q21 170 D 1.00 171 0.685 . B -60 2.8 1.85 ? ? ? ? ? ? ? ? ? ? ? NO 1.437 ? 84.13 +P01112 170 K D ? P01112 170 K D ? ? benign alignment ? neutral 0.119 0.141 0.926 0.171 NO NO ? +1.552 -2.023 -3.575 2 118 20 7 6q21 170 D 1.00 171 0.685 . B -57 1.59 1.85 ? ? ? ? ? ? ? ? ? ? ? NO 6.746 ? 84.13 +P01112 170 K E ? P01112 170 K E A G benign alignment ? neutral 0.001 0.852 0.994 0.514 NO NO ? +0.440 -2.023 -2.463 2 118 20 7 6q21 170 D 1.00 171 0.685 . B -30 1.3 1.85 ? ? ? ? ? ? ? 0 0 0 -58 NO 14.774 14.774 84.13 +P01112 170 K F ? P01112 170 K F ? ? benign alignment ? neutral 0.273 0.116 0.908 0.148 NO NO ? +2.333 -2.023 -4.356 2 118 20 7 6q21 170 D 1.00 171 0.685 . B 22 2.92 1.85 ? ? ? ? ? ? ? ? ? ? ? NO 3.654 ? 84.13 +P01112 170 K G ? P01112 170 K G ? ? benign alignment ? neutral 0.002 0.704 0.987 0.452 NO NO ? +0.795 -2.023 -2.818 2 118 20 7 6q21 170 D 1.00 171 0.685 . B -108 2.05 1.85 ? ? ? ? ? ? ? ? ? ? ? NO 38.576 38.576 84.13 +P01112 170 K H ? P01112 170 K H ? ? benign alignment ? neutral 0.001 0.852 0.994 0.514 NO NO ? +0.992 -2.023 -3.015 2 118 20 7 6q21 170 D 1.00 171 0.685 . B -15 2.17 1.85 ? ? ? ? ? ? ? ? ? ? ? NO 26.225 26.225 84.13 +P01112 170 K I ? P01112 170 K I ? ? benign alignment ? neutral 0 1 1 0.575 NO NO ? +1.127 -2.023 -3.150 2 118 20 7 6q21 170 D 1.00 171 0.685 . B -1 2.82 1.85 ? ? ? ? ? ? ? ? ? ? ? NO 22.125 22.125 84.13 +P01112 170 K L ? P01112 170 K L ? ? benign alignment ? neutral 0 1 1 0.575 NO NO ? +0.869 -2.023 -2.892 2 118 20 7 6q21 170 D 1.00 171 0.685 . B -1 2.89 1.85 ? ? ? ? ? ? ? ? ? ? ? NO 16.888 16.888 84.13 +P01112 170 K M ? P01112 170 K M A T benign alignment ? neutral 0.079 0.154 0.933 0.183 NO NO ? +2.661 -2.023 -4.684 2 118 20 7 6q21 170 D 1.00 171 0.685 . B -5 2.89 1.85 ? ? ? ? ? ? ? 1 1 0 -59 NO 3.009 ? 84.13 +P01112 170 K N ? P01112 170 K N G C benign alignment ? neutral 0.001 0.852 0.994 0.514 NO NO ? +0.712 -2.023 -2.735 2 118 20 7 6q21 170 D 1.00 171 0.685 . B -54 1.73 1.85 ? ? ? ? ? ? ? 1 2 0 -60 NO 25.639 25.639 84.13 +P01112 170 K P ? P01112 170 K P ? ? benign alignment ? neutral 0.002 0.704 0.987 0.452 NO NO ? +0.766 -2.023 -2.789 2 118 20 7 6q21 170 D 1.00 171 0.685 . B -56 1.82 1.85 ? ? ? ? ? ? ? ? ? ? ? NO 41.620 41.620 84.13 +P01112 170 K Q ? P01112 170 K Q A C benign alignment ? neutral 0.001 0.852 0.994 0.514 NO NO ? +0.804 -2.023 -2.827 2 118 20 7 6q21 170 D 1.00 171 0.685 . B -24 1.7 1.85 ? ? ? ? ? ? ? 1 0 0 -58 NO 16.866 16.866 84.13 +P01112 170 K R ? P01112 170 K R A G benign alignment ? neutral 0 1 1 0.575 NO NO ? +0.548 -2.023 -2.571 2 118 20 7 6q21 170 D 1.00 171 0.685 . B 5 1.14 1.85 ? ? ? ? ? ? ? 0 1 0 -59 NO 28.397 28.397 84.13 +P01112 170 K S ? P01112 170 K S ? ? benign alignment ? neutral 0.004 0.408 0.975 0.328 NO NO ? +0.623 -2.023 -2.646 2 118 20 7 6q21 170 D 1.00 171 0.685 . B -79 2.07 1.85 ? ? ? ? ? ? ? ? ? ? ? NO 17.338 17.338 84.13 +P01112 170 K T ? P01112 170 K T A C benign alignment ? neutral 0 1 1 0.575 NO NO ? +0.670 -2.023 -2.693 2 118 20 7 6q21 170 D 1.00 171 0.685 . B -52 2.12 1.85 ? ? ? ? ? ? ? 1 1 2 -59 NO 19.127 19.127 84.13 +P01112 170 K V ? P01112 170 K V ? ? benign alignment ? neutral 0.002 0.704 0.987 0.452 NO NO ? +1.594 -2.023 -3.617 2 118 20 7 6q21 170 D 1.00 171 0.685 . B -28 2.78 1.85 ? ? ? ? ? ? ? ? ? ? ? NO 14.364 ? 84.13 +P01112 170 K W ? P01112 170 K W ? ? probably damaging alignment ? deleterious 0.97 0.0446 0.769 0.0728 NO NO ? +3.464 -2.023 -5.487 2 118 20 7 6q21 170 D 1.00 171 0.685 . B 59 2.81 1.85 ? ? ? ? ? ? ? ? ? ? ? NO 0.523 ? 84.13 +P01112 170 K Y ? P01112 170 K Y ? ? benign alignment ? neutral 0.042 0.172 0.943 0.198 NO NO ? +2.233 -2.023 -4.256 2 118 20 7 6q21 170 D 1.00 171 0.685 . B 25 2.55 1.85 ? ? ? ? ? ? ? ? ? ? ? NO 4.299 ? 84.13 +P01112 171 L A ? P01112 171 L A ? ? benign alignment ? neutral 0.053 0.164 0.94 0.191 NO NO ? +1.161 -2.112 -3.273 2 109 20 7 6q21 171 D 1.00 171 1.591 . ? -79 0.55 1.77 ? ? ? ? ? ? ? ? ? ? ? NO 8.382 ? 85.19 +P01112 171 L C ? P01112 171 L C ? ? benign alignment ? neutral 0.011 0.222 0.959 0.239 NO NO ? +1.419 -2.112 -3.531 2 109 20 7 6q21 171 D 1.00 171 1.591 . ? -59 0.09 1.77 ? ? ? ? ? ? ? ? ? ? ? NO 36.567 36.567 85.19 +P01112 171 L D ? P01112 171 L D ? ? benign alignment ? neutral 0.001 0.852 0.994 0.514 NO NO ? +0.690 -2.112 -2.802 2 109 20 7 6q21 171 D 1.00 171 1.591 . ? -56 1.3 1.77 ? ? ? ? ? ? ? ? ? ? ? NO 29.387 29.387 85.19 +P01112 171 L E ? P01112 171 L E ? ? benign alignment ? neutral 0.003 0.556 0.981 0.39 NO NO ? +0.498 -2.112 -2.610 2 109 20 7 6q21 171 D 1.00 171 1.591 . ? -29 1.59 1.77 ? ? ? ? ? ? ? ? ? ? ? NO 15.089 15.089 85.19 +P01112 171 L F ? P01112 171 L F ? ? benign alignment ? neutral 0.273 0.116 0.908 0.148 NO NO ? +2.168 -2.112 -4.280 2 109 20 7 6q21 171 D 1.00 171 1.591 . ? 23 0.03 1.77 ? ? ? ? ? ? ? ? ? ? ? NO 3.956 ? 85.19 +P01112 171 L G ? P01112 171 L G ? ? benign alignment ? neutral 0.001 0.852 0.994 0.514 NO NO ? +0.423 -2.112 -2.535 2 109 20 7 6q21 171 D 1.00 171 1.591 . ? -107 0.84 1.77 ? ? ? ? ? ? ? ? ? ? ? NO 42.893 42.893 85.19 +P01112 171 L H ? P01112 171 L H ? ? benign alignment ? neutral 0.443 0.1 0.89 0.133 NO NO ? +2.674 -2.112 -4.786 2 109 20 7 6q21 171 D 1.00 171 1.591 . ? -14 0.72 1.77 ? ? ? ? ? ? ? ? ? ? ? NO 2.610 ? 85.19 +P01112 171 L I ? P01112 171 L I ? ? benign alignment ? neutral 0 1 1 0.575 NO NO ? +0.763 -2.112 -2.875 2 109 20 7 6q21 171 D 1.00 171 1.591 . ? 0 0.07 1.77 ? ? ? ? ? ? ? ? ? ? ? NO 23.130 23.130 85.19 +P01112 171 L K ? P01112 171 L K ? ? benign alignment ? neutral 0 1 1 0.575 NO NO ? +0.884 -2.112 -2.996 2 109 20 7 6q21 171 D 1.00 171 1.591 . ? 1 2.89 1.77 ? ? ? ? ? ? ? ? ? ? ? NO 20.964 20.964 85.19 +P01112 171 L M ? P01112 171 L M C A benign alignment ? neutral 0.002 0.704 0.987 0.452 NO NO ? +1.341 -2.112 -3.453 2 109 20 7 6q21 171 D 1.00 171 1.591 . ? -4 0 1.77 ? ? ? ? ? ? ? 1 0 0 -61 NO 13.455 13.455 85.19 +P01112 171 L N ? P01112 171 L N ? ? benign alignment ? neutral 0.002 0.704 0.987 0.452 NO NO ? +0.769 -2.112 -2.881 2 109 20 7 6q21 171 D 1.00 171 1.591 . ? -53 1.16 1.77 ? ? ? ? ? ? ? ? ? ? ? NO 25.807 25.807 85.19 +P01112 171 L P ? P01112 171 L P T C benign alignment ? neutral 0.001 0.852 0.994 0.514 NO NO ? +0.802 -2.112 -2.914 2 109 20 7 6q21 171 D 1.00 171 1.591 . ? -55 1.07 1.77 ? ? ? ? ? ? ? 0 1 2 -62 NO 33.768 33.768 85.19 +P01112 171 L Q ? P01112 171 L Q T A benign alignment ? neutral 0.003 0.556 0.981 0.39 NO NO ? +0.862 -2.112 -2.974 2 109 20 7 6q21 171 D 1.00 171 1.591 . ? -23 1.19 1.77 ? ? ? ? ? ? ? 1 1 0 -62 NO 17.092 17.092 85.19 +P01112 171 L R ? P01112 171 L R T G benign alignment ? neutral 0.001 0.852 0.994 0.514 NO NO ? +0.824 -2.112 -2.936 2 109 20 7 6q21 171 D 1.00 171 1.591 . ? 6 1.75 1.77 ? ? ? ? ? ? ? 1 1 2 -62 NO 27.851 27.851 85.19 +P01112 171 L S ? P01112 171 L S ? ? benign alignment ? neutral 0.004 0.408 0.975 0.328 NO NO ? +0.652 -2.112 -2.764 2 109 20 7 6q21 171 D 1.00 171 1.591 . ? -78 0.82 1.77 ? ? ? ? ? ? ? ? ? ? ? NO 16.872 16.872 85.19 +P01112 171 L T ? P01112 171 L T ? ? benign alignment ? neutral 0.003 0.556 0.981 0.39 NO NO ? +0.881 -2.112 -2.993 2 109 20 7 6q21 171 D 1.00 171 1.591 . ? -51 0.77 1.77 ? ? ? ? ? ? ? ? ? ? ? NO 16.394 16.394 85.19 +P01112 171 L V ? P01112 171 L V C G benign alignment ? neutral 0 1 1 0.575 NO NO ? +0.823 -2.112 -2.935 2 109 20 7 6q21 171 D 1.00 171 1.591 . ? -27 0.11 1.77 ? ? ? ? ? ? ? 1 0 0 -61 NO 20.513 20.513 85.19 +P01112 171 L W ? P01112 171 L W ? ? probably damaging alignment ? deleterious 0.97 0.0446 0.769 0.0728 NO NO ? +3.385 -2.112 -5.497 2 109 20 7 6q21 171 D 1.00 171 1.591 . ? 60 0.08 1.77 ? ? ? ? ? ? ? ? ? ? ? NO 0.661 ? 85.19 +P01112 171 L Y ? P01112 171 L Y ? ? benign alignment ? neutral 0.082 0.153 0.933 0.181 NO NO ? +2.257 -2.112 -4.369 2 109 20 7 6q21 171 D 1.00 171 1.591 . ? 26 0.34 1.77 ? ? ? ? ? ? ? ? ? ? ? NO 1.900 ? 85.19 +P01112 172 N A ? P01112 172 N A ? ? benign alignment ? neutral 0.002 0.704 0.987 0.452 NO NO ? +0.481 -2.044 -2.525 2 107 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NO 23.142 23.142 85.71 +P01112 172 N C ? P01112 172 N C ? ? possibly damaging alignment ? deleterious 0.934 0.0572 0.803 0.088 NO NO ? +3.025 -2.044 -5.069 2 107 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NO 1.712 ? 85.71 +P01112 172 N D ? P01112 172 N D A G benign alignment ? neutral 0.003 0.556 0.981 0.39 NO NO ? +0.829 -2.044 -2.873 2 107 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 0 0 0 -64 NO 33.375 33.375 85.71 +P01112 172 N E ? P01112 172 N E ? ? benign alignment ? neutral 0.004 0.408 0.975 0.328 NO NO ? +0.807 -2.044 -2.851 2 107 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NO 21.219 21.219 85.71 +P01112 172 N F ? P01112 172 N F ? ? possibly damaging alignment ? deleterious 0.651 0.0877 0.866 0.121 NO NO ? +2.219 -2.044 -4.263 2 107 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NO 3.393 ? 85.71 +P01112 172 N G ? P01112 172 N G ? ? benign alignment ? neutral 0.099 0.146 0.93 0.175 NO NO ? +1.364 -2.044 -3.408 2 107 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NO 6.261 ? 85.71 +P01112 172 N H ? P01112 172 N H A C benign alignment ? neutral 0.003 0.556 0.981 0.39 NO NO ? +0.937 -2.044 -2.981 2 107 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 1 0 0 -64 NO 29.971 29.971 85.71 +P01112 172 N I ? P01112 172 N I A T benign alignment ? neutral 0.003 0.556 0.981 0.39 NO NO ? +0.984 -2.044 -3.028 2 107 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 1 1 0 -65 NO 20.544 20.544 85.71 +P01112 172 N K ? P01112 172 N K C G benign alignment ? neutral 0.001 0.852 0.994 0.514 NO NO ? +0.610 -2.044 -2.654 2 107 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 1 2 0 -66 NO 21.550 21.550 85.71 +P01112 172 N L ? P01112 172 N L ? ? benign alignment ? neutral 0.007 0.246 0.965 0.257 NO NO ? +0.406 -2.044 -2.450 2 107 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NO 18.279 18.279 85.71 +P01112 172 N M ? P01112 172 N M ? ? possibly damaging alignment ? deleterious 0.651 0.0877 0.866 0.121 NO NO ? +2.580 -2.044 -4.624 2 107 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NO 2.794 ? 85.71 +P01112 172 N P ? P01112 172 N P ? ? benign alignment ? neutral 0.004 0.408 0.975 0.328 NO NO ? +0.725 -2.044 -2.769 2 107 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NO 31.935 31.935 85.71 +P01112 172 N Q ? P01112 172 N Q ? ? possibly damaging alignment ? neutral 0.483 0.0982 0.886 0.131 NO NO ? +1.887 -2.044 -3.931 2 107 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NO 4.654 ? 85.71 +P01112 172 N R ? P01112 172 N R ? ? benign alignment ? neutral 0.004 0.408 0.975 0.328 NO NO ? +0.981 -2.044 -3.025 2 107 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NO 26.395 26.395 85.71 +P01112 172 N S ? P01112 172 N S A G benign alignment ? neutral 0.005 0.26 0.968 0.267 NO NO ? +0.406 -2.044 -2.450 2 107 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 0 1 0 -65 NO 18.850 18.850 85.71 +P01112 172 N T ? P01112 172 N T A C benign alignment ? neutral 0.167 0.131 0.92 0.162 NO NO ? +1.459 -2.044 -3.503 2 107 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 1 1 0 -65 NO 7.040 ? 85.71 +P01112 172 N V ? P01112 172 N V ? ? benign alignment ? neutral 0.004 0.408 0.975 0.328 NO NO ? +0.840 -2.044 -2.884 2 107 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NO 20.655 20.655 85.71 +P01112 172 N W ? P01112 172 N W ? ? probably damaging alignment ? deleterious 0.977 0.0424 0.758 0.0704 NO NO ? +3.502 -2.044 -5.546 2 107 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NO 0.490 ? 85.71 +P01112 172 N Y ? P01112 172 N Y A T benign alignment ? neutral 0.413 0.103 0.893 0.135 NO NO ? +2.187 -2.044 -4.231 2 107 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 1 0 0 -64 NO 4.913 ? 85.71 +P01112 173 P A ? P01112 173 P A C G benign alignment ? neutral 0.021 0.196 0.951 0.219 NO NO ? +0.866 -2.322 -3.188 2 101 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 1 0 2 -67 NO 9.422 ? 86.24 +P01112 173 P C ? P01112 173 P C ? ? probably damaging alignment ? deleterious 0.962 0.0478 0.779 0.0767 NO NO ? +2.802 -2.322 -5.124 2 101 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NO 1.572 ? 86.24 +P01112 173 P D ? P01112 173 P D ? ? benign alignment ? neutral 0.001 0.852 0.994 0.514 NO NO ? +0.493 -2.322 -2.815 2 101 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NO 30.436 30.436 86.24 +P01112 173 P E ? P01112 173 P E ? ? benign alignment ? neutral 0 1 1 0.575 NO NO ? +0.253 -2.322 -2.575 2 101 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NO 19.175 19.175 86.24 +P01112 173 P F ? P01112 173 P F ? ? benign alignment ? neutral 0.01 0.226 0.96 0.242 NO NO ? +0.853 -2.322 -3.175 2 101 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NO 17.335 17.335 86.24 +P01112 173 P G ? P01112 173 P G ? ? benign alignment ? neutral 0.001 0.852 0.994 0.514 NO NO ? +0.400 -2.322 -2.722 2 101 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NO 40.195 40.195 86.24 +P01112 173 P H ? P01112 173 P H C A benign alignment ? neutral 0.452 0.0998 0.889 0.132 NO NO ? +2.297 -2.322 -4.619 2 101 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 1 1 0 -68 NO 2.695 ? 86.24 +P01112 173 P I ? P01112 173 P I ? ? benign alignment ? neutral 0.135 0.138 0.924 0.168 NO NO ? +1.652 -2.322 -3.974 2 101 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NO 5.176 ? 86.24 +P01112 173 P K ? P01112 173 P K ? ? benign alignment ? neutral 0 1 1 0.575 NO NO ? +0.096 -2.322 -2.418 2 101 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NO 23.749 23.749 86.24 +P01112 173 P L ? P01112 173 P L C T benign alignment ? neutral 0.003 0.556 0.981 0.39 NO NO ? +0.536 -2.322 -2.858 2 101 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 0 1 0 -68 NO 16.888 16.888 86.24 +P01112 173 P M ? P01112 173 P M ? ? possibly damaging alignment ? deleterious 0.689 0.083 0.861 0.116 NO NO ? +2.364 -2.322 -4.686 2 101 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NO 2.241 ? 86.24 +P01112 173 P N ? P01112 173 P N ? ? benign alignment ? neutral 0 1 1 0.575 NO NO ? +0.349 -2.322 -2.671 2 101 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NO 26.645 26.645 86.24 +P01112 173 P Q ? P01112 173 P Q ? ? benign alignment ? neutral 0.004 0.408 0.975 0.328 NO NO ? +0.708 -2.322 -3.030 2 101 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NO 15.394 15.394 86.24 +P01112 173 P R ? P01112 173 P R C G benign alignment ? neutral 0.001 0.852 0.994 0.514 NO NO ? +0.654 -2.322 -2.976 2 101 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 1 1 2 -68 NO 26.213 26.213 86.24 +P01112 173 P S ? P01112 173 P S C T benign alignment ? neutral 0 1 1 0.575 NO NO ? -0.061 -2.322 -2.261 2 101 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 0 0 0 -67 NO 18.967 18.967 86.24 +P01112 173 P T ? P01112 173 P T C A benign alignment ? neutral 0 1 1 0.575 NO NO ? +0.285 -2.322 -2.607 2 101 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 1 0 0 -67 NO 19.647 19.647 86.24 +P01112 173 P V ? P01112 173 P V ? ? benign alignment ? neutral 0.06 0.161 0.938 0.189 NO NO ? +1.327 -2.322 -3.649 2 101 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NO 5.715 ? 86.24 +P01112 173 P W ? P01112 173 P W ? ? probably damaging alignment ? deleterious 0.962 0.0478 0.779 0.0767 NO NO ? +3.098 -2.322 -5.420 2 101 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NO 0.805 ? 86.24 +P01112 173 P Y ? P01112 173 P Y ? ? possibly damaging alignment ? deleterious 0.522 0.096 0.882 0.129 NO NO ? +1.934 -2.322 -4.256 2 101 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NO 4.021 ? 86.24 +P01112 174 P A ? P01112 174 P A C G benign alignment ? neutral 0.005 0.26 0.968 0.267 NO NO ? +0.508 -2.165 -2.673 2 103 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 1 0 0 -70 NO 15.633 15.633 86.24 +P01112 174 P C ? P01112 174 P C ? ? probably damaging alignment ? deleterious 0.977 0.0424 0.758 0.0704 NO NO ? +2.984 -2.165 -5.149 2 103 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NO 1.572 ? 86.24 +P01112 174 P D ? P01112 174 P D ? ? benign alignment ? neutral 0.007 0.246 0.965 0.257 NO NO ? +0.657 -2.165 -2.822 2 103 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NO 18.262 18.262 86.24 +P01112 174 P E ? P01112 174 P E ? ? benign alignment ? neutral 0.001 0.852 0.994 0.514 NO NO ? +0.249 -2.165 -2.414 2 103 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NO 25.462 25.462 86.24 +P01112 174 P F ? P01112 174 P F ? ? possibly damaging alignment ? deleterious 0.651 0.0877 0.866 0.121 NO NO ? +2.255 -2.165 -4.420 2 103 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NO 3.417 ? 86.24 +P01112 174 P G ? P01112 174 P G ? ? benign alignment ? neutral 0.001 0.852 0.994 0.514 NO NO ? +0.348 -2.165 -2.513 2 103 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NO 42.893 42.893 86.24 +P01112 174 P H ? P01112 174 P H C A possibly damaging alignment ? deleterious 0.585 0.0931 0.875 0.126 NO NO ? +2.474 -2.165 -4.639 2 103 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 1 1 0 -71 NO 2.729 ? 86.24 +P01112 174 P I ? P01112 174 P I ? ? benign alignment ? neutral 0.004 0.408 0.975 0.328 NO NO ? +0.965 -2.165 -3.130 2 103 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NO 20.688 20.688 86.24 +P01112 174 P K ? P01112 174 P K ? ? benign alignment ? neutral 0.001 0.852 0.994 0.514 NO NO ? +0.120 -2.165 -2.285 2 103 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NO 22.430 22.430 86.24 +P01112 174 P L ? P01112 174 P L C T benign alignment ? neutral 0.167 0.131 0.92 0.162 NO NO ? +1.401 -2.165 -3.566 2 103 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 0 1 0 -71 NO 12.769 ? 86.24 +P01112 174 P M ? P01112 174 P M ? ? possibly damaging alignment ? deleterious 0.651 0.0877 0.866 0.121 NO NO ? +2.589 -2.165 -4.754 2 103 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NO 2.814 ? 86.24 +P01112 174 P N ? P01112 174 P N ? ? benign alignment ? neutral 0.002 0.704 0.987 0.452 NO NO ? +0.532 -2.165 -2.697 2 103 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NO 26.980 26.980 86.24 +P01112 174 P Q ? P01112 174 P Q ? ? benign alignment ? neutral 0.016 0.207 0.955 0.227 NO NO ? +0.874 -2.165 -3.039 2 103 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NO 14.488 14.488 86.24 +P01112 174 P R ? P01112 174 P R C G benign alignment ? neutral 0.003 0.556 0.981 0.39 NO NO ? +0.817 -2.165 -2.982 2 103 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 1 1 2 -71 NO 28.761 28.761 86.24 +P01112 174 P S ? P01112 174 P S C T benign alignment ? neutral 0.005 0.26 0.968 0.267 NO NO ? +0.418 -2.165 -2.583 2 103 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 0 0 0 -70 NO 18.967 18.967 86.24 +P01112 174 P T ? P01112 174 P T C A benign alignment ? neutral 0.005 0.26 0.968 0.267 NO NO ? +0.690 -2.165 -2.855 2 103 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 1 0 0 -70 NO 17.695 17.695 86.24 +P01112 174 P V ? P01112 174 P V ? ? benign alignment ? neutral 0.084 0.152 0.932 0.181 NO NO ? +1.442 -2.165 -3.607 2 103 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NO 13.431 ? 86.24 +P01112 174 P W ? P01112 174 P W ? ? probably damaging alignment ? deleterious 0.977 0.0424 0.758 0.0704 NO NO ? +3.364 -2.165 -5.529 2 103 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NO 0.462 ? 86.24 +P01112 174 P Y ? P01112 174 P Y ? ? possibly damaging alignment ? deleterious 0.92 0.0592 0.81 0.0901 NO NO ? +2.226 -2.165 -4.391 2 103 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NO 1.552 ? 86.24 +P01112 175 D A ? P01112 175 D A A C benign alignment ? neutral 0.001 0.852 0.994 0.514 NO NO ? +0.219 -2.507 -2.726 2 99 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 1 1 0 -74 NO 14.406 14.406 85.71 +P01112 175 D C ? P01112 175 D C ? ? benign alignment ? neutral 0.002 0.704 0.987 0.452 NO NO ? +0.929 -2.507 -3.436 2 99 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NO 40.658 40.658 85.71 +P01112 175 D E ? P01112 175 D E T G benign alignment ? neutral 0 1 1 0.575 NO NO ? +0.148 -2.507 -2.655 2 99 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 1 2 0 -75 NO 25.462 25.462 85.71 +P01112 175 D F ? P01112 175 D F ? ? possibly damaging alignment ? deleterious 0.689 0.083 0.861 0.116 NO NO ? +1.858 -2.507 -4.365 2 99 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NO 2.520 ? 85.71 +P01112 175 D G ? P01112 175 D G A G benign alignment ? neutral 0 1 1 0.575 NO NO ? -0.101 -2.507 -2.406 2 99 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 0 1 0 -74 NO 39.656 39.656 85.71 +P01112 175 D H ? P01112 175 D H G C possibly damaging alignment ? deleterious 0.626 0.0893 0.869 0.122 NO NO ? +2.178 -2.507 -4.685 2 99 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 1 0 0 -73 NO 2.288 ? 85.71 +P01112 175 D I ? P01112 175 D I ? ? benign alignment ? neutral 0.135 0.138 0.924 0.168 NO NO ? +1.454 -2.507 -3.961 2 99 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NO 5.297 ? 85.71 +P01112 175 D K ? P01112 175 D K ? ? benign alignment ? neutral 0 1 1 0.575 NO NO ? -0.009 -2.507 -2.498 2 99 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NO 22.430 22.430 85.71 +P01112 175 D L ? P01112 175 D L ? ? benign alignment ? neutral 0.002 0.704 0.987 0.452 NO NO ? +0.178 -2.507 -2.685 2 99 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NO 17.286 17.286 85.71 +P01112 175 D M ? P01112 175 D M ? ? benign alignment ? neutral 0.027 0.186 0.948 0.21 NO NO ? +0.902 -2.507 -3.409 2 99 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NO 8.141 8.141 85.71 +P01112 175 D N ? P01112 175 D N G A benign alignment ? neutral 0 1 1 0.575 NO NO ? +0.253 -2.507 -2.760 2 99 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 0 0 0 -73 NO 22.623 22.623 85.71 +P01112 175 D P ? P01112 175 D P ? ? benign alignment ? neutral 0 1 1 0.575 NO NO ? +0.293 -2.507 -2.800 2 99 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NO 36.647 36.647 85.71 +P01112 175 D Q ? P01112 175 D Q ? ? benign alignment ? neutral 0.012 0.219 0.958 0.236 NO NO ? +0.597 -2.507 -3.104 2 99 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NO 10.866 10.866 85.71 +P01112 175 D R ? P01112 175 D R ? ? benign alignment ? neutral 0 1 1 0.575 NO NO ? +0.114 -2.507 -2.621 2 99 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NO 27.487 27.487 85.71 +P01112 175 D S ? P01112 175 D S ? ? benign alignment ? neutral 0.005 0.26 0.968 0.267 NO NO ? +0.336 -2.507 -2.843 2 99 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NO 11.869 11.869 85.71 +P01112 175 D T ? P01112 175 D T ? ? benign alignment ? neutral 0.012 0.219 0.958 0.236 NO NO ? +0.411 -2.507 -2.918 2 99 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NO 11.060 11.060 85.71 +P01112 175 D V ? P01112 175 D V A T benign alignment ? neutral 0.046 0.169 0.942 0.195 NO NO ? +1.132 -2.507 -3.639 2 99 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 1 1 0 -74 NO 4.651 ? 85.71 +P01112 175 D W ? P01112 175 D W ? ? probably damaging alignment ? deleterious 0.962 0.0478 0.779 0.0767 NO NO ? +2.975 -2.507 -5.482 2 99 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NO 0.493 ? 85.71 +P01112 175 D Y ? P01112 175 D Y G T possibly damaging alignment ? deleterious 0.836 0.0687 0.836 0.1 NO NO ? +1.885 -2.507 -4.392 2 99 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 1 0 0 -73 NO 1.434 ? 85.71 +P01112 176 E A ? P01112 176 E A A C benign alignment ? neutral 0 1 1 0.575 NO NO ? +0.073 -2.325 -2.398 2 98 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 1 1 2 -77 NO 20.843 20.843 94.18 +P01112 176 E C ? P01112 176 E C ? ? possibly damaging alignment ? deleterious 0.734 0.0794 0.854 0.112 NO NO ? +2.788 -2.325 -5.113 2 98 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NO 1.542 ? 94.18 +P01112 176 E D ? P01112 176 E D G C benign alignment ? neutral 0 1 1 0.575 NO NO ? +0.351 -2.325 -2.676 2 98 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 1 2 0 -78 NO 37.363 37.363 94.18 +P01112 176 E F ? P01112 176 E F ? ? benign alignment ? neutral 0.056 0.163 0.939 0.19 NO NO ? +1.904 -2.325 -4.229 2 98 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NO 6.392 ? 94.18 +P01112 176 E G ? P01112 176 E G A G benign alignment ? neutral 0.005 0.26 0.968 0.267 NO NO ? +1.152 -2.325 -3.477 2 98 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 0 1 0 -77 NO 5.639 ? 94.18 +P01112 176 E H ? P01112 176 E H ? ? benign alignment ? neutral 0.001 0.852 0.994 0.514 NO NO ? +1.000 -2.325 -3.325 2 98 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NO 29.784 29.784 94.18 +P01112 176 E I ? P01112 176 E I ? ? benign alignment ? neutral 0.017 0.205 0.954 0.225 NO NO ? +1.528 -2.325 -3.853 2 98 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NO 11.294 ? 94.18 +P01112 176 E K ? P01112 176 E K G A benign alignment ? neutral 0 1 1 0.575 NO NO ? +0.169 -2.325 -2.494 2 98 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 0 0 0 -76 NO 23.749 23.749 94.18 +P01112 176 E L ? P01112 176 E L ? ? benign alignment ? neutral 0 1 1 0.575 NO NO ? +0.179 -2.325 -2.504 2 98 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NO 18.875 18.875 94.18 +P01112 176 E M ? P01112 176 E M ? ? benign alignment ? neutral 0.194 0.126 0.917 0.157 NO NO ? +2.323 -2.325 -4.648 2 98 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NO 2.505 ? 94.18 +P01112 176 E N ? P01112 176 E N ? ? benign alignment ? neutral 0 1 1 0.575 NO NO ? +0.442 -2.325 -2.767 2 98 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NO 22.623 22.623 94.18 +P01112 176 E P ? P01112 176 E P ? ? benign alignment ? neutral 0 1 1 0.575 NO NO ? +0.471 -2.325 -2.796 2 98 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NO 37.956 37.956 94.18 +P01112 176 E Q ? P01112 176 E Q G C benign alignment ? neutral 0 1 1 0.575 NO NO ? +0.519 -2.325 -2.844 2 98 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 1 0 0 -76 NO 17.092 17.092 94.18 +P01112 176 E R ? P01112 176 E R ? ? benign alignment ? neutral 0 1 1 0.575 NO NO ? +0.713 -2.325 -3.038 2 98 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NO 23.664 23.664 94.18 +P01112 176 E S ? P01112 176 E S ? ? benign alignment ? neutral 0 1 1 0.575 NO NO ? +0.333 -2.325 -2.658 2 98 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NO 17.803 17.803 94.18 +P01112 176 E T ? P01112 176 E T ? ? benign alignment ? neutral 0.007 0.246 0.965 0.257 NO NO ? +1.238 -2.325 -3.563 2 98 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NO 6.649 ? 94.18 +P01112 176 E V ? P01112 176 E V A T benign alignment ? neutral 0 1 1 0.575 NO NO ? +0.619 -2.325 -2.944 2 98 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 1 1 0 -77 NO 18.518 18.518 94.18 +P01112 176 E W ? P01112 176 E W ? ? possibly damaging alignment ? deleterious 0.734 0.0794 0.854 0.112 NO NO ? +3.106 -2.325 -5.431 2 98 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NO 1.338 ? 94.18 +P01112 176 E Y ? P01112 176 E Y ? ? benign alignment ? neutral 0.001 0.852 0.994 0.514 NO NO ? +0.873 -2.325 -3.198 2 98 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NO 15.450 15.450 94.18 +P01112 177 S A ? P01112 177 S A ? ? benign alignment ? neutral 0 1 1 0.575 NO NO ? +0.329 -2.167 -2.496 2 97 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NO 18.698 18.698 94.18 +P01112 177 S C ? P01112 177 S C A T possibly damaging alignment ? deleterious 0.655 0.087 0.865 0.12 NO NO ? +2.883 -2.167 -5.050 2 97 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 1 0 0 -79 NO 1.567 ? 94.18 +P01112 177 S D ? P01112 177 S D ? ? benign alignment ? neutral 0 1 1 0.575 NO NO ? +0.732 -2.167 -2.899 2 97 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NO 30.226 30.226 94.18 +P01112 177 S E ? P01112 177 S E ? ? benign alignment ? neutral 0 1 1 0.575 NO NO ? +0.696 -2.167 -2.863 2 97 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NO 21.376 21.376 94.18 +P01112 177 S F ? P01112 177 S F ? ? benign alignment ? neutral 0.098 0.146 0.93 0.175 NO NO ? +2.162 -2.167 -4.329 2 97 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NO 4.142 ? 94.18 +P01112 177 S G ? P01112 177 S G A G benign alignment ? neutral 0 1 1 0.575 NO NO ? +0.202 -2.167 -2.369 2 97 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 0 0 0 -79 NO 43.972 43.972 94.18 +P01112 177 S H ? P01112 177 S H ? ? benign alignment ? neutral 0.098 0.146 0.93 0.175 NO NO ? +2.525 -2.167 -4.692 2 97 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NO 3.017 ? 94.18 +P01112 177 S I ? P01112 177 S I G T benign alignment ? neutral 0.012 0.219 0.958 0.236 NO NO ? +1.765 -2.167 -3.932 2 97 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 1 1 0 -80 NO 8.707 ? 94.18 +P01112 177 S K ? P01112 177 S K ? ? benign alignment ? neutral 0 1 1 0.575 NO NO ? +0.500 -2.167 -2.667 2 97 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NO 22.430 22.430 94.18 +P01112 177 S L ? P01112 177 S L ? ? benign alignment ? neutral 0 1 1 0.575 NO NO ? +0.694 -2.167 -2.861 2 97 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NO 28.412 28.412 94.18 +P01112 177 S M ? P01112 177 S M ? ? benign alignment ? neutral 0.003 0.556 0.981 0.39 NO NO ? +0.917 -2.167 -3.084 2 97 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NO 12.341 12.341 94.18 +P01112 177 S N ? P01112 177 S N G A benign alignment ? neutral 0 1 1 0.575 NO NO ? +0.569 -2.167 -2.736 2 97 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 0 1 0 -80 NO 29.829 29.829 94.18 +P01112 177 S P ? P01112 177 S P ? ? benign alignment ? neutral 0 1 1 0.575 NO NO ? +0.610 -2.167 -2.777 2 97 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NO 25.129 25.129 94.18 +P01112 177 S Q ? P01112 177 S Q ? ? benign alignment ? neutral 0.001 0.852 0.994 0.514 NO NO ? +0.933 -2.167 -3.100 2 97 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NO 17.997 17.997 94.18 +P01112 177 S R ? P01112 177 S R T A benign alignment ? neutral 0 1 1 0.575 NO NO ? +0.879 -2.167 -3.046 2 97 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 1 2 0 -81 NO 28.761 28.761 94.18 +P01112 177 S T ? P01112 177 S T G C benign alignment ? neutral 0 1 1 0.575 NO NO ? +0.315 -2.167 -2.482 2 97 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 1 1 0 -80 NO 21.078 21.078 94.18 +P01112 177 S V ? P01112 177 S V ? ? benign alignment ? neutral 0.015 0.209 0.956 0.229 NO NO ? +1.420 -2.167 -3.587 2 97 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NO 7.251 ? 94.18 +P01112 177 S W ? P01112 177 S W ? ? possibly damaging alignment ? deleterious 0.716 0.0809 0.858 0.113 NO NO ? +3.292 -2.167 -5.459 2 97 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NO 0.606 ? 94.18 +P01112 177 S Y ? P01112 177 S Y ? ? benign alignment ? neutral 0.18 0.129 0.918 0.16 NO NO ? +2.210 -2.167 -4.377 2 97 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NO 1.742 ? 94.18 +P01112 178 G A ? P01112 178 G A G C benign alignment ? neutral 0 1 1 0.575 NO NO ? +0.346 -2.359 -2.705 2 96 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 1 1 0 -83 NO 22.529 22.529 86.24 +P01112 178 G C ? P01112 178 G C G T possibly damaging alignment ? deleterious 0.771 0.0758 0.85 0.108 NO NO ? +2.781 -2.359 -5.140 2 96 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 1 0 0 -82 NO 1.667 ? 86.24 +P01112 178 G D ? P01112 178 G D G A benign alignment ? neutral 0.025 0.189 0.949 0.213 NO NO ? +1.230 -2.359 -3.589 2 96 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 0 1 0 -83 NO 7.054 ? 86.24 +P01112 178 G E ? P01112 178 G E ? ? benign alignment ? neutral 0 1 1 0.575 NO NO ? +0.273 -2.359 -2.632 2 96 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NO 22.633 22.633 86.24 +P01112 178 G F ? P01112 178 G F ? ? benign alignment ? neutral 0.226 0.121 0.913 0.152 NO NO ? +1.907 -2.359 -4.266 2 96 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NO 11.048 ? 86.24 +P01112 178 G H ? P01112 178 G H ? ? benign alignment ? neutral 0.369 0.108 0.898 0.14 NO NO ? +2.220 -2.359 -4.579 2 96 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NO 3.965 ? 86.24 +P01112 178 G I ? P01112 178 G I ? ? benign alignment ? neutral 0.077 0.154 0.933 0.183 NO NO ? +1.611 -2.359 -3.970 2 96 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NO 8.829 ? 86.24 +P01112 178 G K ? P01112 178 G K ? ? benign alignment ? neutral 0 1 1 0.575 NO NO ? -0.057 -2.359 -2.302 2 96 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NO 23.163 23.163 86.24 +P01112 178 G L ? P01112 178 G L ? ? benign alignment ? neutral 0 1 1 0.575 NO NO ? +0.299 -2.359 -2.658 2 96 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NO 28.809 28.809 86.24 +P01112 178 G M ? P01112 178 G M ? ? benign alignment ? neutral 0.369 0.108 0.898 0.14 NO NO ? +2.332 -2.359 -4.691 2 96 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NO 3.824 ? 86.24 +P01112 178 G N ? P01112 178 G N ? ? benign alignment ? neutral 0 1 1 0.575 NO NO ? +0.009 -2.359 -2.368 2 96 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NO 26.812 26.812 86.24 +P01112 178 G P ? P01112 178 G P ? ? benign alignment ? neutral 0 1 1 0.575 NO NO ? +0.181 -2.359 -2.540 2 96 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NO 42.406 42.406 86.24 +P01112 178 G Q ? P01112 178 G Q ? ? benign alignment ? neutral 0.002 0.704 0.987 0.452 NO NO ? +0.705 -2.359 -3.064 2 96 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NO 16.413 16.413 86.24 +P01112 178 G R ? P01112 178 G R G C benign alignment ? neutral 0 1 1 0.575 NO NO ? +0.389 -2.359 -2.748 2 96 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 1 0 2 -82 NO 23.664 23.664 86.24 +P01112 178 G S ? P01112 178 G S G A benign alignment ? neutral 0.025 0.189 0.949 0.213 NO NO ? +1.012 -2.359 -3.371 2 96 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 0 0 0 -82 NO 7.966 ? 86.24 +P01112 178 G T ? P01112 178 G T ? ? benign alignment ? neutral 0 1 1 0.575 NO NO ? +0.118 -2.359 -2.477 2 96 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NO 21.208 21.208 86.24 +P01112 178 G V ? P01112 178 G V G T benign alignment ? neutral 0.025 0.189 0.949 0.213 NO NO ? +1.256 -2.359 -3.615 2 96 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 1 1 0 -83 NO 7.352 ? 86.24 +P01112 178 G W ? P01112 178 G W ? ? possibly damaging alignment ? deleterious 0.817 0.0705 0.84 0.102 NO NO ? +3.020 -2.359 -5.379 2 96 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NO 2.313 ? 86.24 +P01112 178 G Y ? P01112 178 G Y ? ? benign alignment ? neutral 0.001 0.852 0.994 0.514 NO NO ? +0.825 -2.359 -3.184 2 96 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NO 26.702 26.702 86.24 +P01112 179 P A ? P01112 179 P A C G benign alignment ? neutral 0 1 1 0.575 NO NO ? +0.326 -2.381 -2.707 2 94 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 1 0 2 -85 NO 24.368 24.368 94.18 +P01112 179 P C ? P01112 179 P C ? ? benign alignment ? neutral 0.114 0.142 0.927 0.172 NO NO ? +2.741 -2.381 -5.122 2 94 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NO 1.803 ? 94.18 +P01112 179 P D ? P01112 179 P D ? ? benign alignment ? neutral 0 1 1 0.575 NO NO ? +0.516 -2.381 -2.897 2 94 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NO 31.696 31.696 94.18 +P01112 179 P E ? P01112 179 P E ? ? benign alignment ? neutral 0.004 0.408 0.975 0.328 NO NO ? +1.051 -2.381 -3.432 2 94 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NO 9.728 ? 94.18 +P01112 179 P F ? P01112 179 P F ? ? benign alignment ? neutral 0.06 0.161 0.938 0.189 NO NO ? +1.975 -2.381 -4.356 2 94 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NO 4.142 ? 94.18 +P01112 179 P G ? P01112 179 P G ? ? benign alignment ? neutral 0 1 1 0.575 NO NO ? +0.164 -2.381 -2.545 2 94 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NO 43.432 43.432 94.18 +P01112 179 P H ? P01112 179 P H C A benign alignment ? neutral 0 1 1 0.575 NO NO ? +0.927 -2.381 -3.308 2 94 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 1 1 0 -86 NO 28.098 28.098 94.18 +P01112 179 P I ? P01112 179 P I ? ? benign alignment ? neutral 0.002 0.704 0.987 0.452 NO NO ? +0.740 -2.381 -3.121 2 94 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NO 13.217 13.217 94.18 +P01112 179 P K ? P01112 179 P K ? ? benign alignment ? neutral 0 1 1 0.575 NO NO ? +0.090 -2.381 -2.471 2 94 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NO 21.110 21.110 94.18 +P01112 179 P L ? P01112 179 P L C T benign alignment ? neutral 0 1 1 0.575 NO NO ? +0.495 -2.381 -2.876 2 94 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 0 1 0 -86 NO 28.412 28.412 94.18 +P01112 179 P M ? P01112 179 P M ? ? benign alignment ? neutral 0.06 0.161 0.938 0.189 NO NO ? +2.303 -2.381 -4.684 2 94 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NO 3.771 ? 94.18 +P01112 179 P N ? P01112 179 P N ? ? benign alignment ? neutral 0 1 1 0.575 NO NO ? +0.152 -2.381 -2.533 2 94 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NO 25.639 25.639 94.18 +P01112 179 P Q ? P01112 179 P Q ? ? benign alignment ? neutral 0 1 1 0.575 NO NO ? +0.261 -2.381 -2.642 2 94 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NO 20.148 20.148 94.18 +P01112 179 P R ? P01112 179 P R C G benign alignment ? neutral 0 1 1 0.575 NO NO ? +0.391 -2.381 -2.772 2 94 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 1 1 2 -86 NO 29.489 29.489 94.18 +P01112 179 P S ? P01112 179 P S C T benign alignment ? neutral 0 1 1 0.575 NO NO ? +0.238 -2.381 -2.619 2 94 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 0 0 0 -85 NO 17.338 17.338 94.18 +P01112 179 P T ? P01112 179 P T C A benign alignment ? neutral 0.001 0.852 0.994 0.514 NO NO ? +0.502 -2.381 -2.883 2 94 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 1 0 0 -85 NO 11.190 11.190 94.18 +P01112 179 P V ? P01112 179 P V ? ? benign alignment ? neutral 0.004 0.408 0.975 0.328 NO NO ? +1.217 -2.381 -3.598 2 94 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NO 8.581 ? 94.18 +P01112 179 P W ? P01112 179 P W ? ? possibly damaging alignment ? deleterious 0.596 0.0919 0.874 0.125 NO NO ? +3.119 -2.381 -5.500 2 94 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NO 0.625 ? 94.18 +P01112 179 P Y ? P01112 179 P Y ? ? benign alignment ? neutral 0.031 0.181 0.947 0.205 NO NO ? +1.913 -2.381 -4.294 2 94 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NO 4.606 ? 94.18 +P01112 180 G A ? P01112 180 G A G C benign alignment ? neutral 0.005 0.26 0.968 0.267 NO NO ? +1.207 -1.907 -3.114 2 91 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 1 1 0 -89 NO 9.191 ? 94.18 +P01112 180 G C ? P01112 180 G C G T benign alignment ? neutral 0.001 0.852 0.994 0.514 NO NO ? +1.348 -1.907 -3.255 2 91 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 1 0 1 -88 NO 41.425 41.425 94.18 +P01112 180 G D ? P01112 180 G D G A benign alignment ? neutral 0 1 1 0.575 NO NO ? +0.631 -1.907 -2.538 2 91 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 0 1 0 -89 NO 37.363 37.363 94.18 +P01112 180 G E ? P01112 180 G E ? ? benign alignment ? neutral 0.001 0.852 0.994 0.514 NO NO ? +0.827 -1.907 -2.734 2 91 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NO 13.517 13.517 94.18 +P01112 180 G F ? P01112 180 G F ? ? benign alignment ? neutral 0.098 0.146 0.93 0.175 NO NO ? +2.462 -1.907 -4.369 2 91 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NO 2.711 ? 94.18 +P01112 180 G H ? P01112 180 G H ? ? possibly damaging alignment ? neutral 0.453 0.0997 0.889 0.132 NO NO ? +2.765 -1.907 -4.672 2 91 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NO 1.921 ? 94.18 +P01112 180 G I ? P01112 180 G I ? ? benign alignment ? neutral 0.051 0.165 0.941 0.192 NO NO ? +2.037 -1.907 -3.944 2 91 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NO 12.597 ? 94.18 +P01112 180 G K ? P01112 180 G K ? ? benign alignment ? neutral 0 1 1 0.575 NO NO ? +0.278 -1.907 -2.185 2 91 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NO 21.550 21.550 94.18 +P01112 180 G L ? P01112 180 G L ? ? benign alignment ? neutral 0.015 0.209 0.956 0.229 NO NO ? +1.641 -1.907 -3.548 2 91 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NO 9.973 ? 94.18 +P01112 180 G M ? P01112 180 G M ? ? possibly damaging alignment ? neutral 0.453 0.0997 0.889 0.132 NO NO ? +2.826 -1.907 -4.733 2 91 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NO 2.433 ? 94.18 +P01112 180 G N ? P01112 180 G N ? ? benign alignment ? neutral 0.015 0.209 0.956 0.229 NO NO ? +1.738 -1.907 -3.645 2 91 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NO 6.534 ? 94.18 +P01112 180 G P ? P01112 180 G P ? ? benign alignment ? neutral 0 1 1 0.575 NO NO ? +0.989 -1.907 -2.896 2 91 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NO 37.956 37.956 94.18 +P01112 180 G Q ? P01112 180 G Q ? ? benign alignment ? neutral 0.098 0.146 0.93 0.175 NO NO ? +1.962 -1.907 -3.869 2 91 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NO 4.142 ? 94.18 +P01112 180 G R ? P01112 180 G R G C benign alignment ? neutral 0 1 1 0.575 NO NO ? +0.547 -1.907 -2.454 2 91 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 1 0 3 -88 NO 27.487 27.487 94.18 +P01112 180 G S ? P01112 180 G S G A benign alignment ? neutral 0.004 0.408 0.975 0.328 NO NO ? +0.816 -1.907 -2.723 2 91 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 0 0 1 -88 NO 18.501 18.501 94.18 +P01112 180 G T ? P01112 180 G T ? ? benign alignment ? neutral 0 1 1 0.575 NO NO ? +0.879 -1.907 -2.786 2 91 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NO 19.907 19.907 94.18 +P01112 180 G V ? P01112 180 G V G T benign alignment ? neutral 0 1 1 0.575 NO NO ? +0.957 -1.907 -2.864 2 91 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 1 1 0 -89 NO 20.655 20.655 94.18 +P01112 180 G W ? P01112 180 G W ? ? possibly damaging alignment ? deleterious 0.716 0.0809 0.858 0.113 NO NO ? +3.514 -1.907 -5.421 2 91 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NO 0.503 ? 94.18 +P01112 180 G Y ? P01112 180 G Y ? ? benign alignment ? neutral 0.18 0.129 0.918 0.16 NO NO ? +2.464 -1.907 -4.371 2 91 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NO 1.630 ? 94.18 +P01112 181 C A ? P01112 181 C A ? ? benign sequence annotation 2.2 neutral 0.006 0.253 0.967 0.262 LIPID NO ? +0.689 -2.493 -3.182 2 90 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NO 8.266 ? 85.71 +P01112 181 C D ? P01112 181 C D ? ? benign sequence annotation 2.2 neutral 0.033 0.179 0.946 0.204 LIPID NO ? +1.169 -2.493 -3.662 2 90 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NO 6.349 ? 85.71 +P01112 181 C E ? P01112 181 C E ? ? benign sequence annotation 2.2 neutral 0.001 0.852 0.994 0.514 LIPID NO ? +0.101 -2.493 -2.594 2 90 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NO 14.460 14.460 85.71 +P01112 181 C F ? P01112 181 C F G T benign sequence annotation 2.2 neutral 0 1 1 0.575 LIPID NO ? +0.556 -2.493 -3.049 2 90 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 1 1 0 -92 NO 29.572 29.572 85.71 +P01112 181 C G ? P01112 181 C G T G benign sequence annotation 2.2 neutral 0.025 0.189 0.949 0.213 LIPID NO ? +1.058 -2.493 -3.551 2 90 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 1 0 2 -91 NO 5.069 ? 85.71 +P01112 181 C H ? P01112 181 C H ? ? benign sequence annotation 2.2 neutral 0.369 0.108 0.898 0.14 LIPID NO ? +2.057 -2.493 -4.550 2 90 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NO 3.616 ? 85.71 +P01112 181 C I ? P01112 181 C I ? ? benign sequence annotation 2.2 neutral 0.012 0.219 0.958 0.236 LIPID NO ? +1.221 -2.493 -3.714 2 90 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NO 14.074 ? 85.71 +P01112 181 C K ? P01112 181 C K ? ? benign sequence annotation 2.2 neutral 0 1 1 0.575 LIPID NO ? +0.088 -2.493 -2.581 2 90 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NO 21.550 21.550 85.71 +P01112 181 C L ? P01112 181 C L ? ? benign sequence annotation 2.2 neutral 0.005 0.26 0.968 0.267 LIPID NO ? +0.807 -2.493 -3.300 2 90 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NO 16.594 ? 85.71 +P01112 181 C M ? P01112 181 C M ? ? benign sequence annotation 2.2 neutral 0.005 0.26 0.968 0.267 LIPID NO ? +0.777 -2.493 -3.270 2 90 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NO 13.626 13.626 85.71 +P01112 181 C N ? P01112 181 C N ? ? benign sequence annotation 2.2 neutral 0.001 0.852 0.994 0.514 LIPID NO ? +0.451 -2.493 -2.944 2 90 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NO 24.131 24.131 85.71 +P01112 181 C P ? P01112 181 C P ? ? benign sequence annotation 2.2 neutral 0.252 0.118 0.911 0.15 LIPID NO ? +1.529 -2.493 -4.022 2 90 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NO 2.203 ? 85.71 +P01112 181 C Q ? P01112 181 C Q ? ? benign sequence annotation 2.2 neutral 0.001 0.852 0.994 0.514 LIPID NO ? +0.267 -2.493 -2.760 2 90 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NO 17.997 17.997 85.71 +P01112 181 C R ? P01112 181 C R T C benign sequence annotation 2.2 neutral 0 1 1 0.575 LIPID NO ? +0.219 -2.493 -2.712 2 90 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 0 0 2 -91 NO 27.851 27.851 85.71 +P01112 181 C S ? P01112 181 C S T A benign sequence annotation 2.2 neutral 0.001 0.852 0.994 0.514 LIPID NO ? +0.305 -2.493 -2.798 2 90 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 1 0 0 -91 NO 16.640 16.640 85.71 +P01112 181 C T ? P01112 181 C T ? ? benign sequence annotation 2.2 neutral 0 1 1 0.575 LIPID NO ? +0.325 -2.493 -2.818 2 90 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NO 19.647 19.647 85.71 +P01112 181 C V ? P01112 181 C V ? ? benign sequence annotation 2.2 neutral 0 1 1 0.575 LIPID NO ? +0.111 -2.493 -2.604 2 90 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NO 23.077 23.077 85.71 +P01112 181 C W ? P01112 181 C W C G possibly damaging sequence annotation 2.2 neutral 0.472 0.0988 0.887 0.131 LIPID NO ? +2.680 -2.493 -5.173 2 90 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 1 2 0 -93 NO 2.109 ? 85.71 +P01112 181 C Y ? P01112 181 C Y G A benign sequence annotation 2.2 neutral 0 1 1 0.575 LIPID NO ? +0.275 -2.493 -2.768 2 90 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 0 1 0 -92 NO 24.351 24.351 85.71 +P01112 182 M A ? P01112 182 M A ? ? benign alignment ? neutral 0.003 0.556 0.981 0.39 NO NO ? +0.089 -2.543 -2.632 2 81 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NO 13.334 13.334 85.71 +P01112 182 M C ? P01112 182 M C ? ? benign alignment ? neutral 0.001 0.852 0.994 0.514 NO NO ? +0.762 -2.543 -3.305 2 81 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NO 40.658 40.658 85.71 +P01112 182 M D ? P01112 182 M D ? ? benign alignment ? neutral 0.033 0.179 0.946 0.204 NO NO ? +1.195 -2.543 -3.738 2 81 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NO 7.098 ? 85.71 +P01112 182 M E ? P01112 182 M E ? ? benign alignment ? neutral 0.033 0.179 0.946 0.204 NO NO ? +1.003 -2.543 -3.546 2 81 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NO 8.744 ? 85.71 +P01112 182 M F ? P01112 182 M F ? ? benign alignment ? neutral 0.077 0.154 0.933 0.183 NO NO ? +1.626 -2.543 -4.169 2 81 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NO 4.606 ? 85.71 +P01112 182 M G ? P01112 182 M G ? ? benign alignment ? neutral 0 1 1 0.575 NO NO ? +0.196 -2.543 -2.739 2 81 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NO 25.628 25.628 85.71 +P01112 182 M H ? P01112 182 M H ? ? benign alignment ? neutral 0.369 0.108 0.898 0.14 NO NO ? +2.136 -2.543 -4.679 2 81 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NO 2.729 ? 85.71 +P01112 182 M I ? P01112 182 M I G C benign alignment ? neutral 0 1 1 0.575 NO NO ? +0.413 -2.543 -2.956 2 81 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 1 2 0 -96 NO 22.843 22.843 85.71 +P01112 182 M K ? P01112 182 M K T A benign alignment ? neutral 0 1 1 0.575 NO NO ? -0.133 -2.543 -2.410 2 81 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 1 1 0 -95 NO 23.749 23.749 85.71 +P01112 182 M L ? P01112 182 M L A C benign alignment ? neutral 0 1 1 0.575 NO NO ? -0.065 -2.543 -2.478 2 81 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 1 0 0 -94 NO 31.591 31.591 85.71 +P01112 182 M N ? P01112 182 M N ? ? benign alignment ? neutral 0 1 1 0.575 NO NO ? +0.148 -2.543 -2.691 2 81 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NO 26.980 26.980 85.71 +P01112 182 M P ? P01112 182 M P ? ? benign alignment ? neutral 0.252 0.118 0.911 0.15 NO NO ? +1.461 -2.543 -4.004 2 81 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NO 2.326 ? 85.71 +P01112 182 M Q ? P01112 182 M Q ? ? benign alignment ? neutral 0.002 0.704 0.987 0.452 NO NO ? +0.495 -2.543 -3.038 2 81 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NO 18.111 18.111 85.71 +P01112 182 M R ? P01112 182 M R T G benign alignment ? neutral 0 1 1 0.575 NO NO ? -0.028 -2.543 -2.515 2 81 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 1 1 0 -95 NO 29.307 29.307 85.71 +P01112 182 M S ? P01112 182 M S ? ? benign alignment ? neutral 0.001 0.852 0.994 0.514 NO NO ? +0.031 -2.543 -2.574 2 81 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NO 17.571 17.571 85.71 +P01112 182 M T ? P01112 182 M T T C benign alignment ? neutral 0 1 1 0.575 NO NO ? +0.275 -2.543 -2.818 2 81 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 0 1 2 -95 NO 20.818 20.818 85.71 +P01112 182 M V ? P01112 182 M V A G benign alignment ? neutral 0.004 0.408 0.975 0.328 NO NO ? +0.843 -2.543 -3.386 2 81 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 0 0 2 -94 NO 14.830 ? 85.71 +P01112 182 M W ? P01112 182 M W ? ? possibly damaging alignment ? deleterious 0.931 0.0577 0.805 0.0885 NO NO ? +2.819 -2.543 -5.362 2 81 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NO 0.623 ? 85.71 +P01112 182 M Y ? P01112 182 M Y ? ? benign alignment ? neutral 0.252 0.118 0.911 0.15 NO NO ? +1.723 -2.543 -4.266 2 81 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NO 1.879 ? 85.71 +P01112 183 S A ? P01112 183 S A ? ? benign alignment ? neutral 0.002 0.704 0.987 0.452 NO NO ? +0.762 -2.419 -3.181 2 79 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NO 6.765 ? 94.18 +P01112 183 S C ? P01112 183 S C A T benign alignment ? neutral 0 1 1 0.575 NO NO ? +0.301 -2.419 -2.720 2 79 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 1 0 0 -97 NO 37.078 37.078 94.18 +P01112 183 S D ? P01112 183 S D ? ? benign alignment ? neutral 0.004 0.408 0.975 0.328 NO NO ? +1.200 -2.419 -3.619 2 79 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NO 7.848 ? 94.18 +P01112 183 S E ? P01112 183 S E ? ? benign alignment ? neutral 0 1 1 0.575 NO NO ? +0.198 -2.419 -2.617 2 79 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NO 13.517 13.517 94.18 +P01112 183 S F ? P01112 183 S F ? ? benign alignment ? neutral 0 1 1 0.575 NO NO ? +0.691 -2.419 -3.110 2 79 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NO 32.019 32.019 94.18 +P01112 183 S G ? P01112 183 S G A G benign alignment ? neutral 0 1 1 0.575 NO NO ? +0.089 -2.419 -2.508 2 79 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 0 0 0 -97 NO 43.972 43.972 94.18 +P01112 183 S H ? P01112 183 S H ? ? benign alignment ? neutral 0 1 1 0.575 NO NO ? +0.818 -2.419 -3.237 2 79 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NO 29.784 29.784 94.18 +P01112 183 S I ? P01112 183 S I G T benign alignment ? neutral 0 1 1 0.575 NO NO ? +0.586 -2.419 -3.005 2 79 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 1 1 0 -98 NO 23.130 23.130 94.18 +P01112 183 S K ? P01112 183 S K ? ? benign alignment ? neutral 0.004 0.408 0.975 0.328 NO NO ? +1.075 -2.419 -3.494 2 79 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NO 10.161 ? 94.18 +P01112 183 S L ? P01112 183 S L ? ? benign alignment ? neutral 0 1 1 0.575 NO NO ? +0.326 -2.419 -2.745 2 79 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NO 32.187 32.187 94.18 +P01112 183 S M ? P01112 183 S M ? ? benign alignment ? neutral 0.002 0.704 0.987 0.452 NO NO ? +0.871 -2.419 -3.290 2 79 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NO 11.655 11.655 94.18 +P01112 183 S N ? P01112 183 S N G A benign alignment ? neutral 0 1 1 0.575 NO NO ? +0.259 -2.419 -2.678 2 79 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 0 1 0 -98 NO 29.829 29.829 94.18 +P01112 183 S P ? P01112 183 S P ? ? benign alignment ? neutral 0.035 0.177 0.945 0.202 NO NO ? +1.633 -2.419 -4.052 2 79 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NO 1.815 ? 94.18 +P01112 183 S Q ? P01112 183 S Q ? ? benign alignment ? neutral 0 1 1 0.575 NO NO ? +0.365 -2.419 -2.784 2 79 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NO 14.715 14.715 94.18 +P01112 183 S R ? P01112 183 S R C A benign alignment ? neutral 0 1 1 0.575 NO NO ? +0.123 -2.419 -2.542 2 79 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 1 2 0 -99 NO 28.943 28.943 94.18 +P01112 183 S T ? P01112 183 S T G C benign alignment ? neutral 0.003 0.556 0.981 0.39 NO NO ? +1.133 -2.419 -3.552 2 79 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 1 1 0 -98 NO 4.717 ? 94.18 +P01112 183 S V ? P01112 183 S V ? ? benign alignment ? neutral 0.001 0.852 0.994 0.514 NO NO ? +1.097 -2.419 -3.516 2 79 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NO 15.017 ? 94.18 +P01112 183 S W ? P01112 183 S W ? ? possibly damaging alignment ? deleterious 0.596 0.0919 0.874 0.125 NO NO ? +2.894 -2.419 -5.313 2 79 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NO 1.488 ? 94.18 +P01112 183 S Y ? P01112 183 S Y ? ? benign alignment ? neutral 0.009 0.233 0.961 0.247 NO NO ? +1.692 -2.419 -4.111 2 79 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NO 7.426 ? 94.18 +P01112 184 C A ? P01112 184 C A ? ? benign sequence annotation 2.2 neutral 0.001 0.852 0.994 0.514 LIPID NO ? -0.076 -2.460 -2.384 2 79 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NO 13.180 13.180 86.24 +P01112 184 C D ? P01112 184 C D ? ? benign sequence annotation 2.2 neutral 0.143 0.136 0.923 0.166 LIPID NO ? +1.406 -2.460 -3.866 2 79 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NO 4.225 ? 86.24 +P01112 184 C E ? P01112 184 C E ? ? benign sequence annotation 2.2 neutral 0.033 0.179 0.946 0.204 LIPID NO ? +1.271 -2.460 -3.731 2 79 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NO 6.053 ? 86.24 +P01112 184 C F ? P01112 184 C F G T benign sequence annotation 2.2 neutral 0 1 1 0.575 LIPID NO ? +0.596 -2.460 -3.056 2 79 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 1 1 0 -101 NO 26.105 26.105 86.24 +P01112 184 C G ? P01112 184 C G T G benign sequence annotation 2.2 neutral 0 1 1 0.575 LIPID NO ? +0.035 -2.460 -2.495 2 79 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 1 0 2 -100 NO 24.818 24.818 86.24 +P01112 184 C H ? P01112 184 C H ? ? possibly damaging sequence annotation 2.2 deleterious 0.542 0.0949 0.88 0.128 LIPID NO ? +2.380 -2.460 -4.840 2 79 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NO 2.060 ? 86.24 +P01112 184 C I ? P01112 184 C I ? ? benign sequence annotation 2.2 neutral 0 1 1 0.575 LIPID NO ? +0.169 -2.460 -2.629 2 79 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NO 22.843 22.843 86.24 +P01112 184 C K ? P01112 184 C K ? ? benign sequence annotation 2.2 neutral 0 1 1 0.575 LIPID NO ? +0.176 -2.460 -2.636 2 79 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NO 23.603 23.603 86.24 +P01112 184 C L ? P01112 184 C L ? ? benign sequence annotation 2.2 neutral 0 1 1 0.575 LIPID NO ? -0.018 -2.460 -2.442 2 79 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NO 32.386 32.386 86.24 +P01112 184 C M ? P01112 184 C M ? ? benign sequence annotation 2.2 neutral 0.369 0.108 0.898 0.14 LIPID NO ? +2.018 -2.460 -4.478 2 79 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NO 4.298 ? 86.24 +P01112 184 C N ? P01112 184 C N ? ? benign sequence annotation 2.2 neutral 0.077 0.154 0.933 0.183 LIPID NO ? +1.457 -2.460 -3.917 2 79 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NO 4.742 ? 86.24 +P01112 184 C P ? P01112 184 C P ? ? benign sequence annotation 2.2 neutral 0.252 0.118 0.911 0.15 LIPID NO ? +1.588 -2.460 -4.048 2 79 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NO 2.511 ? 86.24 +P01112 184 C Q ? P01112 184 C Q ? ? benign sequence annotation 2.2 neutral 0.077 0.154 0.933 0.183 LIPID NO ? +1.670 -2.460 -4.130 2 79 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NO 4.536 ? 86.24 +P01112 184 C R ? P01112 184 C R T C benign sequence annotation 2.2 neutral 0 1 1 0.575 LIPID NO ? +0.548 -2.460 -3.008 2 79 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 0 0 2 -100 NO 29.489 29.489 86.24 +P01112 184 C S ? P01112 184 C S T A benign sequence annotation 2.2 neutral 0.001 0.852 0.994 0.514 LIPID NO ? +0.325 -2.460 -2.785 2 79 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 1 0 0 -100 NO 18.967 18.967 86.24 +P01112 184 C T ? P01112 184 C T ? ? benign sequence annotation 2.2 neutral 0 1 1 0.575 LIPID NO ? +0.107 -2.460 -2.567 2 79 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NO 20.688 20.688 86.24 +P01112 184 C V ? P01112 184 C V ? ? benign sequence annotation 2.2 neutral 0 1 1 0.575 LIPID NO ? +0.039 -2.460 -2.499 2 79 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NO 22.507 22.507 86.24 +P01112 184 C W ? P01112 184 C W C G possibly damaging sequence annotation 2.2 deleterious 0.911 0.0607 0.814 0.0918 LIPID NO ? +2.842 -2.460 -5.302 2 79 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 1 2 0 -102 NO 1.213 ? 86.24 +P01112 184 C Y ? P01112 184 C Y G A benign sequence annotation 2.2 neutral 0.059 0.162 0.938 0.189 LIPID NO ? +1.698 -2.460 -4.158 2 79 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 0 1 0 -101 NO 6.055 ? 86.24 +P01112 185 K A ? P01112 185 K A ? ? benign alignment ? neutral 0.002 0.704 0.987 0.452 NO NO ? +0.750 -2.384 -3.134 2 75 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NO 9.249 ? 94.18 +P01112 185 K C ? P01112 185 K C ? ? benign alignment ? neutral 0 1 1 0.575 NO NO ? +0.039 -2.384 -2.423 2 75 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NO 38.613 38.613 94.18 +P01112 185 K D ? P01112 185 K D ? ? benign alignment ? neutral 0.004 0.408 0.975 0.328 NO NO ? +1.351 -2.384 -3.735 2 75 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NO 7.054 ? 94.18 +P01112 185 K E ? P01112 185 K E A G benign alignment ? neutral 0.003 0.556 0.981 0.39 NO NO ? +1.258 -2.384 -3.642 2 75 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 0 0 2 -103 NO 4.915 ? 94.18 +P01112 185 K F ? P01112 185 K F ? ? benign alignment ? neutral 0 1 1 0.575 NO NO ? +0.661 -2.384 -3.045 2 75 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NO 29.164 29.164 94.18 +P01112 185 K G ? P01112 185 K G ? ? benign alignment ? neutral 0 1 1 0.575 NO NO ? +0.317 -2.384 -2.701 2 75 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NO 39.116 39.116 94.18 +P01112 185 K H ? P01112 185 K H ? ? benign alignment ? neutral 0.06 0.161 0.938 0.189 NO NO ? +2.346 -2.384 -4.730 2 75 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NO 2.712 ? 94.18 +P01112 185 K I ? P01112 185 K I ? ? benign alignment ? neutral 0 1 1 0.575 NO NO ? +0.287 -2.384 -2.671 2 75 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NO 21.981 21.981 94.18 +P01112 185 K L ? P01112 185 K L ? ? benign alignment ? neutral 0 1 1 0.575 NO NO ? +0.282 -2.384 -2.666 2 75 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NO 19.074 19.074 94.18 +P01112 185 K M ? P01112 185 K M A T benign alignment ? neutral 0.046 0.169 0.942 0.195 NO NO ? +2.166 -2.384 -4.550 2 75 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 1 1 0 -104 NO 2.990 ? 94.18 +P01112 185 K N ? P01112 185 K N G C benign alignment ? neutral 0 1 1 0.575 NO NO ? +0.521 -2.384 -2.905 2 75 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 1 2 0 -105 NO 26.812 26.812 94.18 +P01112 185 K P ? P01112 185 K P ? ? benign alignment ? neutral 0 1 1 0.575 NO NO ? +0.258 -2.384 -2.642 2 75 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NO 42.667 42.667 94.18 +P01112 185 K Q ? P01112 185 K Q A C benign alignment ? neutral 0.007 0.246 0.965 0.257 NO NO ? +1.663 -2.384 -4.047 2 75 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 1 0 0 -103 NO 4.536 ? 94.18 +P01112 185 K R ? P01112 185 K R A G benign alignment ? neutral 0 1 1 0.575 NO NO ? +0.559 -2.384 -2.943 2 75 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 0 1 0 -104 NO 32.402 32.402 94.18 +P01112 185 K S ? P01112 185 K S ? ? benign alignment ? neutral 0 1 1 0.575 NO NO ? +0.363 -2.384 -2.747 2 75 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NO 18.618 18.618 94.18 +P01112 185 K T ? P01112 185 K T A C benign alignment ? neutral 0 1 1 0.575 NO NO ? +0.154 -2.384 -2.538 2 75 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 1 1 2 -104 NO 19.517 19.517 94.18 +P01112 185 K V ? P01112 185 K V ? ? benign alignment ? neutral 0.001 0.852 0.994 0.514 NO NO ? +0.993 -2.384 -3.377 2 75 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NO 14.271 ? 94.18 +P01112 185 K W ? P01112 185 K W ? ? possibly damaging alignment ? deleterious 0.596 0.0919 0.874 0.125 NO NO ? +2.933 -2.384 -5.317 2 75 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NO 1.355 ? 94.18 +P01112 185 K Y ? P01112 185 K Y ? ? benign alignment ? neutral 0.009 0.233 0.961 0.247 NO NO ? +1.788 -2.384 -4.172 2 75 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NO 6.764 ? 94.18 +P01112 186 C A ? P01112 186 C A ? ? benign sequence annotation 2.2 neutral 0.012 0.219 0.958 0.236 MOD_RES NO ? +0.398 -2.035 -2.433 2 73 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NO 14.713 14.713 80.95 +P01112 186 C D ? P01112 186 C D ? ? benign sequence annotation 2.2 neutral 0.317 0.112 0.903 0.144 MOD_RES NO ? +1.726 -2.035 -3.761 2 73 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NO 5.996 ? 80.95 +P01112 186 C E ? P01112 186 C E ? ? benign sequence annotation 2.2 neutral 0.317 0.112 0.903 0.144 MOD_RES NO ? +1.655 -2.035 -3.690 2 73 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NO 5.376 ? 80.95 +P01112 186 C F ? P01112 186 C F G T possibly damaging sequence annotation 2.2 deleterious 0.71 0.0814 0.858 0.114 MOD_RES NO ? +2.060 -2.035 -4.095 2 73 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 1 1 0 -107 NO 4.345 ? 80.95 +P01112 186 C G ? P01112 186 C G T G benign sequence annotation 2.2 neutral 0.001 0.852 0.994 0.514 MOD_RES NO ? +0.258 -2.035 -2.293 2 73 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 1 0 0 -106 NO 24.818 24.818 80.95 +P01112 186 C H ? P01112 186 C H ? ? possibly damaging sequence annotation 2.2 deleterious 0.868 0.0659 0.828 0.0973 MOD_RES NO ? +2.731 -2.035 -4.766 2 73 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NO 2.305 ? 80.95 +P01112 186 C I ? P01112 186 C I ? ? benign sequence annotation 2.2 neutral 0.003 0.556 0.981 0.39 MOD_RES NO ? +0.665 -2.035 -2.700 2 73 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NO 21.981 21.981 80.95 +P01112 186 C K ? P01112 186 C K ? ? benign sequence annotation 2.2 neutral 0.003 0.556 0.981 0.39 MOD_RES NO ? +0.441 -2.035 -2.476 2 73 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NO 20.964 20.964 80.95 +P01112 186 C L ? P01112 186 C L ? ? benign sequence annotation 2.2 neutral 0.003 0.556 0.981 0.39 MOD_RES NO ? +0.471 -2.035 -2.506 2 73 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NO 29.803 29.803 80.95 +P01112 186 C M ? P01112 186 C M ? ? possibly damaging sequence annotation 2.2 deleterious 0.765 0.0765 0.851 0.109 MOD_RES NO ? +2.400 -2.035 -4.435 2 73 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NO 3.955 ? 80.95 +P01112 186 C N ? P01112 186 C N ? ? benign sequence annotation 2.2 neutral 0.007 0.246 0.965 0.257 MOD_RES NO ? +0.772 -2.035 -2.807 2 73 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NO 22.791 22.791 80.95 +P01112 186 C P ? P01112 186 C P ? ? possibly damaging sequence annotation 2.2 deleterious 0.868 0.0659 0.828 0.0973 MOD_RES NO ? +1.967 -2.035 -4.002 2 73 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NO 2.052 ? 80.95 +P01112 186 C Q ? P01112 186 C Q ? ? possibly damaging sequence annotation 2.2 deleterious 0.765 0.0765 0.851 0.109 MOD_RES NO ? +2.059 -2.035 -4.094 2 73 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NO 4.029 ? 80.95 +P01112 186 C R ? P01112 186 C R T C possibly damaging sequence annotation 2.2 deleterious 0.551 0.0946 0.879 0.127 MOD_RES NO ? +1.835 -2.035 -3.870 2 73 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 0 0 2 -106 NO 8.110 ? 80.95 +P01112 186 C S ? P01112 186 C S G C benign sequence annotation 2.2 neutral 0.126 0.14 0.925 0.17 MOD_RES NO ? +1.340 -2.035 -3.375 2 73 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 1 1 0 -107 NO 5.072 ? 80.95 +P01112 186 C T ? P01112 186 C T ? ? possibly damaging sequence annotation 2.2 neutral 0.481 0.0984 0.886 0.131 MOD_RES NO ? +1.425 -2.035 -3.460 2 73 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NO 3.883 ? 80.95 +P01112 186 C V ? P01112 186 C V ? ? benign sequence annotation 2.2 neutral 0.001 0.852 0.994 0.514 MOD_RES NO ? +0.314 -2.035 -2.349 2 73 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NO 20.940 20.940 80.95 +P01112 186 C W ? P01112 186 C W T G probably damaging sequence annotation 2.2 deleterious 0.983 0.0387 0.745 0.0657 MOD_RES NO ? +3.275 -2.035 -5.310 2 73 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 1 2 0 -108 NO 0.587 ? 80.95 +P01112 186 C Y ? P01112 186 C Y G A possibly damaging sequence annotation 2.2 deleterious 0.833 0.0689 0.837 0.1 MOD_RES NO ? +2.166 -2.035 -4.201 2 73 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 0 1 0 -107 NO 1.773 ? 80.95 +P01112 187 V A ? P01112 187 V A T C benign alignment ? neutral 0.001 0.852 0.994 0.514 NO PROPEP ? +0.450 -1.998 -2.448 2 66 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 0 1 2 -110 NO 24.368 24.368 85.19 +P01112 187 V C ? P01112 187 V C ? ? benign alignment ? neutral 0.002 0.704 0.987 0.452 NO PROPEP ? +0.484 -1.998 -2.482 2 66 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NO 39.891 39.891 85.19 +P01112 187 V D ? P01112 187 V D ? ? possibly damaging alignment ? deleterious 0.646 0.0881 0.866 0.121 NO PROPEP ? +1.873 -1.998 -3.871 2 66 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NO 3.537 ? 85.19 +P01112 187 V E ? P01112 187 V E T A benign alignment ? neutral 0.164 0.132 0.92 0.162 NO PROPEP ? +1.716 -1.998 -3.714 2 66 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 1 1 0 -110 NO 5.978 ? 85.19 +P01112 187 V F ? P01112 187 V F ? ? possibly damaging alignment ? neutral 0.477 0.0986 0.886 0.131 NO PROPEP ? +1.978 -1.998 -3.976 2 66 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NO 4.635 ? 85.19 +P01112 187 V G ? P01112 187 V G T G benign alignment ? neutral 0.164 0.132 0.92 0.162 NO PROPEP ? +1.553 -1.998 -3.551 2 66 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 1 1 0 -110 NO 6.592 ? 85.19 +P01112 187 V H ? P01112 187 V H ? ? possibly damaging alignment ? deleterious 0.933 0.0573 0.804 0.0882 NO PROPEP ? +2.870 -1.998 -4.868 2 66 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NO 1.718 ? 85.19 +P01112 187 V I ? P01112 187 V I ? ? benign alignment ? neutral 0.002 0.704 0.987 0.452 NO PROPEP ? +0.413 -1.998 -2.411 2 66 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NO 23.130 23.130 85.19 +P01112 187 V K ? P01112 187 V K ? ? benign alignment ? neutral 0.004 0.408 0.975 0.328 NO PROPEP ? +0.778 -1.998 -2.776 2 66 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NO 23.309 23.309 85.19 +P01112 187 V L ? P01112 187 V L G C benign alignment ? neutral 0.001 0.852 0.994 0.514 NO PROPEP ? +0.236 -1.998 -2.234 2 66 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 1 0 0 -109 NO 31.790 31.790 85.19 +P01112 187 V M ? P01112 187 V M G A benign alignment ? neutral 0.075 0.155 0.934 0.183 NO PROPEP ? +1.057 -1.998 -3.055 2 66 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 0 0 0 -109 NO 7.284 7.284 85.19 +P01112 187 V N ? P01112 187 V N ? ? possibly damaging alignment ? deleterious 0.646 0.0881 0.866 0.121 NO PROPEP ? +1.958 -1.998 -3.956 2 66 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NO 3.782 ? 85.19 +P01112 187 V P ? P01112 187 V P ? ? possibly damaging alignment ? deleterious 0.787 0.074 0.847 0.106 NO PROPEP ? +1.986 -1.998 -3.984 2 66 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NO 2.445 ? 85.19 +P01112 187 V Q ? P01112 187 V Q ? ? possibly damaging alignment ? deleterious 0.646 0.0881 0.866 0.121 NO PROPEP ? +2.089 -1.998 -4.087 2 66 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NO 4.480 ? 85.19 +P01112 187 V R ? P01112 187 V R ? ? possibly damaging alignment ? neutral 0.477 0.0986 0.886 0.131 NO PROPEP ? +1.943 -1.998 -3.941 2 66 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NO 9.018 ? 85.19 +P01112 187 V S ? P01112 187 V S ? ? benign alignment ? neutral 0.007 0.246 0.965 0.257 NO PROPEP ? +0.693 -1.998 -2.691 2 66 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NO 15.127 15.127 85.19 +P01112 187 V T ? P01112 187 V T ? ? benign alignment ? neutral 0.02 0.198 0.952 0.22 NO PROPEP ? +0.646 -1.998 -2.644 2 66 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NO 11.970 11.970 85.19 +P01112 187 V W ? P01112 187 V W ? ? probably damaging alignment ? deleterious 0.977 0.0424 0.758 0.0704 NO PROPEP ? +3.301 -1.998 -5.299 2 66 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NO 0.627 ? 85.19 +P01112 187 V Y ? P01112 187 V Y ? ? possibly damaging alignment ? deleterious 0.787 0.074 0.847 0.106 NO PROPEP ? +2.145 -1.998 -4.143 2 66 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NO 1.891 ? 85.19 +P01112 188 L A ? P01112 188 L A ? ? benign alignment ? neutral 0.005 0.26 0.968 0.267 NO PROPEP ? +0.974 -2.060 -3.034 2 61 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NO 6.546 ? 94.18 +P01112 188 L C ? P01112 188 L C ? ? benign alignment ? neutral 0 1 1 0.575 NO PROPEP ? +0.982 -2.060 -3.042 2 61 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NO 22.247 22.247 94.18 +P01112 188 L D ? P01112 188 L D ? ? benign alignment ? neutral 0.103 0.144 0.929 0.174 NO PROPEP ? +1.766 -2.060 -3.826 2 61 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NO 2.326 ? 94.18 +P01112 188 L E ? P01112 188 L E ? ? benign alignment ? neutral 0.053 0.164 0.94 0.191 NO PROPEP ? +1.574 -2.060 -3.634 2 61 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NO 3.948 ? 94.18 +P01112 188 L F ? P01112 188 L F C T benign alignment ? neutral 0.13 0.139 0.925 0.169 NO PROPEP ? +1.926 -2.060 -3.986 2 61 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 0 0 0 -112 NO 3.797 ? 94.18 +P01112 188 L G ? P01112 188 L G ? ? benign alignment ? neutral 0 1 1 0.575 NO PROPEP ? +0.529 -2.060 -2.589 2 61 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NO 25.898 25.898 94.18 +P01112 188 L H ? P01112 188 L H T A benign alignment ? neutral 0.232 0.121 0.912 0.152 NO PROPEP ? +2.724 -2.060 -4.784 2 61 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 1 1 0 -113 NO 1.819 ? 94.18 +P01112 188 L I ? P01112 188 L I C A benign alignment ? neutral 0 1 1 0.575 NO PROPEP ? +0.152 -2.060 -2.212 2 61 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 1 0 0 -112 NO 22.987 22.987 94.18 +P01112 188 L K ? P01112 188 L K ? ? benign alignment ? neutral 0.001 0.852 0.994 0.514 NO PROPEP ? +0.377 -2.060 -2.437 2 61 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NO 13.487 13.487 94.18 +P01112 188 L M ? P01112 188 L M ? ? benign alignment ? neutral 0.165 0.131 0.92 0.162 NO PROPEP ? +2.217 -2.060 -4.277 2 61 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NO 3.126 ? 94.18 +P01112 188 L N ? P01112 188 L N ? ? benign alignment ? neutral 0.053 0.164 0.94 0.191 NO PROPEP ? +1.797 -2.060 -3.857 2 61 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NO 2.900 ? 94.18 +P01112 188 L P ? P01112 188 L P T C benign alignment ? neutral 0.232 0.121 0.912 0.152 NO PROPEP ? +1.938 -2.060 -3.998 2 61 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 0 1 0 -113 NO 1.608 ? 94.18 +P01112 188 L Q ? P01112 188 L Q ? ? benign alignment ? neutral 0.165 0.131 0.92 0.162 NO PROPEP ? +1.962 -2.060 -4.022 2 61 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NO 3.644 ? 94.18 +P01112 188 L R ? P01112 188 L R T G benign alignment ? neutral 0 1 1 0.575 NO PROPEP ? +0.762 -2.060 -2.822 2 61 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 1 1 2 -113 NO 26.031 26.031 94.18 +P01112 188 L S ? P01112 188 L S ? ? benign alignment ? neutral 0.002 0.704 0.987 0.452 NO PROPEP ? +0.622 -2.060 -2.682 2 61 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NO 9.891 9.891 94.18 +P01112 188 L T ? P01112 188 L T ? ? benign alignment ? neutral 0.012 0.219 0.958 0.236 NO PROPEP ? +1.374 -2.060 -3.434 2 61 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NO 4.702 ? 94.18 +P01112 188 L V ? P01112 188 L V C G benign alignment ? neutral 0 1 1 0.575 NO PROPEP ? +0.054 -2.060 -2.114 2 61 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 1 0 0 -112 NO 25.356 25.356 94.18 +P01112 188 L W ? P01112 188 L W ? ? possibly damaging alignment ? deleterious 0.822 0.0699 0.839 0.101 NO PROPEP ? +3.263 -2.060 -5.323 2 61 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NO 0.460 ? 94.18 +P01112 188 L Y ? P01112 188 L Y ? ? benign alignment ? neutral 0.286 0.115 0.907 0.147 NO PROPEP ? +2.080 -2.060 -4.140 2 61 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NO 2.001 ? 94.18 +P01112 189 S A ? P01112 189 S A T G benign alignment ? neutral 0.019 0.2 0.953 0.222 NO PROPEP ? +0.831 -2.063 -2.894 2 12 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 1 0 2 -115 NO 3.380 ? 75.66 +P01112 189 S C ? P01112 189 S C C G benign alignment ? neutral 0 1 1 0.575 NO PROPEP ? +0.208 -2.063 -2.271 2 12 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 1 1 0 -116 NO 21.991 21.991 75.66 +P01112 189 S D ? P01112 189 S D ? ? benign alignment ? neutral 0 1 1 0.575 NO PROPEP ? +0.253 -2.063 -2.316 2 12 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NO 20.151 20.151 75.66 +P01112 189 S E ? P01112 189 S E ? ? benign alignment ? neutral 0.029 0.183 0.948 0.207 NO PROPEP ? +1.243 -2.063 -3.306 2 12 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NO 4.656 ? 75.66 +P01112 189 S F ? P01112 189 S F C T benign alignment ? neutral 0.278 0.116 0.908 0.147 NO PROPEP ? +1.851 -2.063 -3.914 2 12 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 0 1 0 -116 NO 4.142 ? 75.66 +P01112 189 S G ? P01112 189 S G ? ? benign alignment ? neutral 0.108 0.143 0.928 0.173 NO PROPEP ? +1.170 -2.063 -3.233 2 12 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NO 2.389 ? 75.66 +P01112 189 S H ? P01112 189 S H ? ? benign alignment ? neutral 0.002 0.704 0.987 0.452 NO PROPEP ? +0.566 -2.063 -2.629 2 12 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NO 17.233 17.233 75.66 +P01112 189 S I ? P01112 189 S I ? ? benign alignment ? neutral 0.068 0.158 0.936 0.186 NO PROPEP ? +1.453 -2.063 -3.516 2 12 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NO 8.707 ? 75.66 +P01112 189 S K ? P01112 189 S K ? ? benign alignment ? neutral 0.228 0.121 0.913 0.152 NO PROPEP ? +1.402 -2.063 -3.465 2 12 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NO 2.316 ? 75.66 +P01112 189 S L ? P01112 189 S L ? ? benign alignment ? neutral 0 1 1 0.575 NO PROPEP ? +0.225 -2.063 -2.288 2 12 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NO 28.412 28.412 75.66 +P01112 189 S M ? P01112 189 S M ? ? benign alignment ? neutral 0.338 0.11 0.901 0.142 NO PROPEP ? +2.298 -2.063 -4.361 2 12 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NO 3.771 ? 75.66 +P01112 189 S N ? P01112 189 S N ? ? benign alignment ? neutral 0.127 0.14 0.925 0.17 NO PROPEP ? +1.390 -2.063 -3.453 2 12 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NO 3.524 ? 75.66 +P01112 189 S P ? P01112 189 S P T C benign alignment ? neutral 0.404 0.105 0.894 0.137 NO PROPEP ? +1.741 -2.063 -3.804 2 12 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 0 0 0 -115 NO 1.172 ? 75.66 +P01112 189 S Q ? P01112 189 S Q ? ? benign alignment ? neutral 0.228 0.121 0.913 0.152 NO PROPEP ? +1.759 -2.063 -3.822 2 12 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NO 1.948 ? 75.66 +P01112 189 S R ? P01112 189 S R ? ? benign alignment ? neutral 0.228 0.121 0.913 0.152 NO PROPEP ? +1.713 -2.063 -3.776 2 12 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NO 2.304 ? 75.66 +P01112 189 S T ? P01112 189 S T T A benign alignment ? neutral 0.084 0.152 0.932 0.181 NO PROPEP ? +1.201 -2.063 -3.264 2 12 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 1 0 0 -115 NO 2.543 ? 75.66 +P01112 189 S V ? P01112 189 S V ? ? benign alignment ? neutral 0.029 0.183 0.948 0.207 NO PROPEP ? +1.266 -2.063 -3.329 2 12 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NO 7.251 ? 75.66 +P01112 189 S W ? P01112 189 S W ? ? possibly damaging alignment ? deleterious 0.922 0.0588 0.809 0.0896 NO PROPEP ? +3.097 -2.063 -5.160 2 12 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NO 0.560 ? 75.66 +P01112 189 S Y ? P01112 189 S Y C A benign alignment ? neutral 0.099 0.146 0.93 0.175 NO PROPEP ? +1.820 -2.063 -3.883 2 12 20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 1 1 0 -116 NO 2.825 ? 75.66 +## Sources: +## Predictions: PolyPhen-2 v2.2.2r398 +## Sequences: UniProtKB/UniRef100 Release 2011_12 (14-Dec-2011) +## Structures: PDB/DSSP Snapshot 03-Jan-2012 (78304 Structures) +## Genes: UCSC MultiZ46Way GRCh37/hg19 (08-Oct-2009) + diff --git a/test/test-2/test-2.py b/test/test-2/test-2.py new file mode 100644 index 0000000..54aa11c --- /dev/null +++ b/test/test-2/test-2.py @@ -0,0 +1,37 @@ +import sys +import os +import shutil +import prody as pd + +# check if rhapsody can be imported correctly +sys.path.append('../../') +import rhapsody as rd + +# temporarily switch to new set of folders +if not os.path.isdir('workspace'): + os.mkdir('workspace') +old_rhaps_dir = pd.SETTINGS.get('rhapsody_local_folder') +pd.SETTINGS['rhapsody_local_folder'] = os.path.abspath('./workspace') + +# train classifiers +rd.initialSetup(download_EVmutation=False) +shutil.copyfile('./data/UniprotMap-P01112.pkl', + './workspace/pickles/UniprotMap-P01112.pkl') + +# let's run a saturation mutagenesis test with a custom PDB structure +os.chdir('workspace') +rh = rd.rhapsody('../data/pph2-full.txt', query_type='PolyPhen2', + main_classifier=rd.getDefaultClassifiers()['reduced'], + custom_PDB='../data/RAS_customPDB.pdb') + +# print figure +rd.print_sat_mutagen_figure('rhapsody-figure.png', rh, html=True, + EVmutation=False) + +# restore previous settings +if old_rhaps_dir is not None: + pd.SETTINGS['rhapsody_local_folder'] = old_rhaps_dir + pd.SETTINGS.save() + +# final check +assert os.path.isfile('rhapsody-figure.png') From bb27010139c4e14d5b788356d9fa100038bb3f4a Mon Sep 17 00:00:00 2001 From: luponzo86 Date: Thu, 29 Aug 2019 17:19:24 -0700 Subject: [PATCH 03/24] test-2 added --- .travis.yml | 1 + 1 file changed, 1 insertion(+) diff --git a/.travis.yml b/.travis.yml index 20a75d3..9ca8eb9 100644 --- a/.travis.yml +++ b/.travis.yml @@ -46,4 +46,5 @@ install: script: # - pytest test1.py - cd test/test-1; python test-1.py + - cd ../test-2; python test-2.py From 7fa0f8955678eea46378629cb413e78199f455c6 Mon Sep 17 00:00:00 2001 From: Luca Ponzoni Date: Fri, 30 Aug 2019 15:15:35 -0400 Subject: [PATCH 04/24] - --- rhapsody/features/PolyPhen2.py | 8 +++++++- 1 file changed, 7 insertions(+), 1 deletion(-) diff --git a/rhapsody/features/PolyPhen2.py b/rhapsody/features/PolyPhen2.py index 7897059..9b095fd 100644 --- a/rhapsody/features/PolyPhen2.py +++ b/rhapsody/features/PolyPhen2.py @@ -7,6 +7,7 @@ from prody import LOGGER, queryUniprot import numpy as np import requests +import datetime from requests.adapters import HTTPAdapter from requests.packages.urllib3.util.retry import Retry from math import log @@ -63,9 +64,14 @@ def _check_log_errors(text): def _print_fasta_file(Uniprot_accs, filename='custom_sequences.fasta'): + date = datetime.date.today() + date = date.replace('-', '') + ### save new names to dict and return it + ### replace new names in input_SAV + ### restore original names in pph2-full with open(filename, 'w', 1) as f: for acc in Uniprot_accs: - f.write(f">{acc}") + f.write(f">{acc}-{date}") record = queryUniprot(acc) sequence = record['sequence 0'] f.write(sequence) From 7175d822e8fd7dcfb1305180bfc511587fff7529 Mon Sep 17 00:00:00 2001 From: luponzo86 Date: Fri, 30 Aug 2019 15:45:07 -0700 Subject: [PATCH 05/24] - --- rhapsody/features/PolyPhen2.py | 68 ++++++++++++++++++++++++---------- 1 file changed, 48 insertions(+), 20 deletions(-) diff --git a/rhapsody/features/PolyPhen2.py b/rhapsody/features/PolyPhen2.py index 9b095fd..5898637 100644 --- a/rhapsody/features/PolyPhen2.py +++ b/rhapsody/features/PolyPhen2.py @@ -4,10 +4,11 @@ classifiers. """ -from prody import LOGGER, queryUniprot -import numpy as np +import os import requests import datetime +import numpy as np +from prody import LOGGER, queryUniprot from requests.adapters import HTTPAdapter from requests.packages.urllib3.util.retry import Retry from math import log @@ -35,6 +36,14 @@ def _requests_retry_session(retries=10, timeout=1, backoff_factor=0.3, status_forcelist=(404,), session=None): # https://www.peterbe.com/plog/best-practice-with-retries-with-requests + # time intervals (in minutes) between retry can be found with: + # [min((backoff_factor*(2**(retries - 1))), 120) / 60 for i in range(30)] + # total time after 12 retries --> ~6 minutes + # total time after 16 retries --> ~14 minutes + # total time after 30 retries --> ~42 minutes + # total time after 60 retries --> ~102 minutes + # total time after 100 retries --> ~182 minutes + # total time after 200 retries --> ~6 hours session = session or requests.Session() retry = Retry(total=retries, read=retries, connect=retries, backoff_factor=backoff_factor, @@ -64,18 +73,28 @@ def _check_log_errors(text): def _print_fasta_file(Uniprot_accs, filename='custom_sequences.fasta'): - date = datetime.date.today() - date = date.replace('-', '') - ### save new names to dict and return it - ### replace new names in input_SAV - ### restore original names in pph2-full + date = datetime.date.today().strftime('%Y%m%d') + new_accs = {} with open(filename, 'w', 1) as f: for acc in Uniprot_accs: - f.write(f">{acc}-{date}") + new_acc = f"{acc}-{date}" + f.write(f">{new_acc}") record = queryUniprot(acc) sequence = record['sequence 0'] f.write(sequence) - return filename + # store new temporary accession numbers + new_accs[acc] = new_acc + return filename, new_accs + + +def _replace_strings(fname, new_fname, dict_substitutions): + with open(fname, 'r') as f: + text = f.read() + for old_str, new_str in dict_substitutions.items(): + text = text.replace(old_str, new_str) + with open(new_fname, 'w') as f: + f.write(text) + return new_fname def queryPolyPhen2(filename, dump=True, prefix='pph2', @@ -128,19 +147,17 @@ def queryPolyPhen2(filename, dump=True, prefix='pph2', # delay = timeout + backoff_factor*[2^(total_retries - 1)] if k == 'started': LOGGER.timeit('_started') - r = _requests_retry_session(retries=16, timeout=0, - backoff_factor=0.1).get(files[k]) + r = _requests_retry_session(retries=16).get(files[k]) LOGGER.report('Query to PolyPhen-2 started in %.1fs.', '_started') LOGGER.info('PolyPhen-2 is running...') elif k == 'completed': LOGGER.timeit('_queryPP2') - r = _requests_retry_session(retries=12, timeout=log(num_lines)/2, - backoff_factor=0.2).get(files[k]) + r = _requests_retry_session( + retries=200, timeout=log(num_lines)/2).get(files[k]) LOGGER.report('Query to PolyPhen-2 completed in %.1fs.', '_queryPP2') else: - r = _requests_retry_session(retries=12, timeout=0, - backoff_factor=0.01).get(files[k]) + r = _requests_retry_session(retries=12).get(files[k]) output[k] = r # print to file, if requested if dump: @@ -148,17 +165,28 @@ def queryPolyPhen2(filename, dump=True, prefix='pph2', print(r.text, file=f) # check for conflicts between Uniprot sequences and isoforms used - # by Polyhen-2 (which could be outdated) + # by Polyhen-2 (which are sometimes outdated) Uniprot_accs = _check_log_errors(output['log'].text) if Uniprot_accs: if fix_isoforms: - LOGGER.info('PolyPhen-2 may have picked the wrong isoforms. ' - 'Resubmitting query with correct isoforms...') + LOGGER.info('PolyPhen-2 may have picked the wrong isoforms.') + LOGGER.info('Resubmitting query with correct isoforms --- ' + 'it may take up to a few hours to complete...') + # print file with freshly downloaded Uniprot sequences + fasta_fname, new_accs = _print_fasta_file(Uniprot_accs) + # replace accession numbers in list of SAVs + tmp_fname = filename + '.tmp' + _replace_strings(filename, tmp_fname, new_accs) # resubmit query by manually uploading fasta sequences - fasta_fname = _print_fasta_file(Uniprot_accs) output = queryPolyPhen2( - filename, dump=dump, prefix=prefix, + tmp_fname, dump=dump, prefix=prefix, fasta_file=fasta_fname, fix_isoforms=False, **kwargs) + os.remove(tmp_fname) + # restore original accession numbers in output files + orig_accs = dict([[v, k] for k, v in new_accs.items()]) + for k in ['short', 'full', 'log', 'snps']: + output_file = f'pph2-{k}.txt' + _replace_strings(output_file, output_file, orig_accs) else: LOGGER.error('Please check PolyPhen-2 log file') From 11893504ee6b15628022c895ea87b13e544a10d0 Mon Sep 17 00:00:00 2001 From: luponzo86 Date: Fri, 30 Aug 2019 22:05:48 -0700 Subject: [PATCH 06/24] - --- rhapsody/features/PolyPhen2.py | 27 ++++++++++++++++++--------- 1 file changed, 18 insertions(+), 9 deletions(-) diff --git a/rhapsody/features/PolyPhen2.py b/rhapsody/features/PolyPhen2.py index 5898637..68f7415 100644 --- a/rhapsody/features/PolyPhen2.py +++ b/rhapsody/features/PolyPhen2.py @@ -87,7 +87,13 @@ def _print_fasta_file(Uniprot_accs, filename='custom_sequences.fasta'): return filename, new_accs -def _replace_strings(fname, new_fname, dict_substitutions): +def _replace_strings_in_text(text, dict_substitutions): + for old_str, new_str in dict_substitutions.items(): + text = text.replace(old_str, new_str) + return text + + +def _replace_strings_in_file(fname, new_fname, dict_substitutions): with open(fname, 'r') as f: text = f.read() for old_str, new_str in dict_substitutions.items(): @@ -143,7 +149,8 @@ def queryPolyPhen2(filename, dump=True, prefix='pph2', # keep checking if the job has started/completed and, # when done, fetch output files output = {} - for k in ['started', 'completed', 'short', 'full', 'log', 'snps']: + exts = ['started', 'completed', 'short', 'full', 'log', 'snps'] + for k in exts: # delay = timeout + backoff_factor*[2^(total_retries - 1)] if k == 'started': LOGGER.timeit('_started') @@ -158,7 +165,7 @@ def queryPolyPhen2(filename, dump=True, prefix='pph2', '_queryPP2') else: r = _requests_retry_session(retries=12).get(files[k]) - output[k] = r + output[k] = r.text # print to file, if requested if dump: with open(prefix + '-' + k + '.txt', 'w', 1) as f: @@ -176,17 +183,19 @@ def queryPolyPhen2(filename, dump=True, prefix='pph2', fasta_fname, new_accs = _print_fasta_file(Uniprot_accs) # replace accession numbers in list of SAVs tmp_fname = filename + '.tmp' - _replace_strings(filename, tmp_fname, new_accs) + _replace_strings_in_file(filename, tmp_fname, new_accs) # resubmit query by manually uploading fasta sequences output = queryPolyPhen2( tmp_fname, dump=dump, prefix=prefix, fasta_file=fasta_fname, fix_isoforms=False, **kwargs) os.remove(tmp_fname) - # restore original accession numbers in output files + # restore original accession numbers in output orig_accs = dict([[v, k] for k, v in new_accs.items()]) - for k in ['short', 'full', 'log', 'snps']: - output_file = f'pph2-{k}.txt' - _replace_strings(output_file, output_file, orig_accs) + for k in exts: + output[k] = _replace_strings_in_text(output[k], orig_accs) + if dump: + outfile = f'pph2-{k}.txt' + _replace_strings_in_file(outfile, outfile, orig_accs) else: LOGGER.error('Please check PolyPhen-2 log file') @@ -199,7 +208,7 @@ def parsePolyPhen2output(pph2_output): ''' assert type(pph2_output) in [dict, str] if type(pph2_output) is dict: - lines = pph2_output['full'].text.split('\n') + lines = pph2_output['full'].split('\n') else: with open(pph2_output, 'r') as file: lines = file.readlines() From f1e95da567b96039606c87201fa710bedc297d52 Mon Sep 17 00:00:00 2001 From: luponzo86 Date: Fri, 30 Aug 2019 23:45:14 -0700 Subject: [PATCH 07/24] - --- rhapsody/features/PolyPhen2.py | 2 +- 1 file changed, 1 insertion(+), 1 deletion(-) diff --git a/rhapsody/features/PolyPhen2.py b/rhapsody/features/PolyPhen2.py index 68f7415..709461c 100644 --- a/rhapsody/features/PolyPhen2.py +++ b/rhapsody/features/PolyPhen2.py @@ -173,7 +173,7 @@ def queryPolyPhen2(filename, dump=True, prefix='pph2', # check for conflicts between Uniprot sequences and isoforms used # by Polyhen-2 (which are sometimes outdated) - Uniprot_accs = _check_log_errors(output['log'].text) + Uniprot_accs = _check_log_errors(output['log']) if Uniprot_accs: if fix_isoforms: LOGGER.info('PolyPhen-2 may have picked the wrong isoforms.') From 03f66a18b7fac42015809a95897b192ba4f4a290 Mon Sep 17 00:00:00 2001 From: luponzo86 Date: Sat, 12 Oct 2019 16:07:20 -0700 Subject: [PATCH 08/24] add protein-stratified CV --- rhapsody/predict/core.py | 8 +++-- rhapsody/train/RFtraining.py | 59 ++++++++++++++++++++++++------------ 2 files changed, 45 insertions(+), 22 deletions(-) diff --git a/rhapsody/predict/core.py b/rhapsody/predict/core.py index dc9b73e..5d33ecb 100644 --- a/rhapsody/predict/core.py +++ b/rhapsody/predict/core.py @@ -905,7 +905,7 @@ def calcPredictions(feat_matrix, clsf, SAV_coords=None): classifier = clsf_dict['trained RF'] opt_cutoff = clsf_dict['CV summary']['optimal cutoff'] path_curve = clsf_dict['CV summary']['path. probability'] - train_data = clsf_dict['training dataset'] + train_data = clsf_dict['CV summary']['training dataset'] LOGGER.timeit('_preds') @@ -931,14 +931,16 @@ def calcPredictions(feat_matrix, clsf, SAV_coords=None): J, err_bar = opt_cutoff Jminus = J - err_bar Jplus = J + err_bar + delSAVs = train_data['SAV_coords'][train_data['true_label'] == 1] + neuSAVs = train_data['SAV_coords'][train_data['true_label'] == 0] k = 0 for i in range(len(feat_matrix)): # determine SAV status if SAV_coords is None: SAV_status = '?' - elif SAV_coords[i] in train_data['del. SAVs']: + elif SAV_coords[i] in delSAVs: SAV_status = 'known_del' - elif SAV_coords[i] in train_data['neu. SAVs']: + elif SAV_coords[i] in neuSAVs: SAV_status = 'known_neu' else: SAV_status = 'new' diff --git a/rhapsody/train/RFtraining.py b/rhapsody/train/RFtraining.py index e2255c7..1cdc9bc 100644 --- a/rhapsody/train/RFtraining.py +++ b/rhapsody/train/RFtraining.py @@ -5,6 +5,7 @@ import pickle import numpy as np import numpy.lib.recfunctions as rfn +from collections import Counter from prody import LOGGER from sklearn.model_selection import StratifiedKFold from sklearn.ensemble import RandomForestClassifier @@ -105,16 +106,39 @@ def _calcSmoothCurve(curve, smooth_window): return smooth_curve -def _performCV(X, y, n_estimators=1000, max_features='auto', n_splits=10, - ROC_fig='ROC.png', feature_names=None, **kwargs): +def _performCV(X, y, sel_SAVs, n_estimators=1000, max_features='auto', + n_splits=10, ROC_fig='ROC.png', feature_names=None, + CVseed=666, protein_stratification=False, **kwargs): # set classifier classifier = RandomForestClassifier( n_estimators=n_estimators, max_features=max_features, oob_score=True, n_jobs=-1, class_weight='balanced') - # set cross-validation procedure - cv = StratifiedKFold(n_splits=n_splits, shuffle=True, random_state=666) + # define folds + cv = StratifiedKFold(n_splits=n_splits, shuffle=True, random_state=CVseed) + CV_folds = [] + for train, test in cv.split(X, y): + CV_folds.append([train, test]) + + # protein-stratification: a same protein should not be found in + # both training and test sets + if protein_stratification: + # for each fold, count occurrences of each accession number + occurrences = {} + accs = np.array([s.split()[0] for s in sel_SAVs['SAV_coords']]) + for k, (train, test) in enumerate(CV_folds): + counts = Counter(accs[test]) + for acc, count in counts.items(): + occurrences.setdefault(acc, np.zeros(n_splits, dtype=int)) + occurrences[acc][k] = count + # for each acc. number, find fold with largest occurrences + best_fold = {a: np.argmax(c) for a, c in occurrences.items()} + new_folds = np.array([best_fold[a] for a in accs]) + # update folds + for k in range(n_splits): + CV_folds[k][0] = np.where(new_folds != k)[0] + CV_folds[k][1] = np.where(new_folds == k)[0] # cross-validation loop CV_info = { @@ -129,7 +153,7 @@ def _performCV(X, y, n_estimators=1000, max_features='auto', n_splits=10, mean_tpr = 0.0 mean_fpr = np.linspace(0, 1, 100) i = 0 - for train, test in cv.split(X, y): + for train, test in CV_folds: # create training and test datasets X_train = X[train] X_test = X[test] @@ -194,7 +218,9 @@ def _performCV(X, y, n_estimators=1000, max_features='auto', n_splits=10, 'mean ROC': list(zip(mean_fpr, mean_tpr)), 'optimal cutoff': (avg_Jopt, std_Jopt), 'feat. importance': avg_feat_imp, - 'path. probability': path_prob + 'path. probability': path_prob, + 'training dataset': sel_SAVs, + 'folds': CV_folds } # plot average ROC @@ -236,16 +262,17 @@ def _importFeatMatrix(fm): # split into feature array and true label array X = np.array([[np.float32(x) for x in v] for v in fms[featset]]) y = fms['true_label'] + sel_SAVs = fms[['SAV_coords', 'true_label']] - return X, y, featset + return X, y, sel_SAVs, featset def RandomForestCV(feat_matrix, n_estimators=1500, max_features=2, **kwargs): - X, y, featset = _importFeatMatrix(feat_matrix) + X, y, sel_SAVs, featset = _importFeatMatrix(feat_matrix) CV_summary = _performCV( - X, y, n_estimators=n_estimators, max_features=max_features, - feature_names=featset, **kwargs) + X, y, sel_SAVs, n_estimators=n_estimators, + max_features=max_features, feature_names=featset, **kwargs) return CV_summary @@ -253,12 +280,12 @@ def trainRFclassifier(feat_matrix, n_estimators=1500, max_features=2, pickle_name='trained_classifier.pkl', feat_imp_fig='feat_importances.png', **kwargs): - X, y, featset = _importFeatMatrix(feat_matrix) + X, y, sel_SAVs, featset = _importFeatMatrix(feat_matrix) # calculate optimal Youden cutoff through CV CV_summary = _performCV( - X, y, n_estimators=n_estimators, max_features=max_features, - feature_names=featset, **kwargs) + X, y, sel_SAVs, n_estimators=n_estimators, + max_features=max_features, feature_names=featset, **kwargs) # train a classifier on the whole dataset clsf = RandomForestClassifier( @@ -278,16 +305,10 @@ def trainRFclassifier(feat_matrix, n_estimators=1500, max_features=2, if feat_imp_fig is not None: print_feat_imp_figure(feat_imp_fig, fimp, featset) - train_info = { - 'del. SAVs': feat_matrix[feat_matrix['true_label'] == 1]['SAV_coords'], - 'neu. SAVs': feat_matrix[feat_matrix['true_label'] == 0]['SAV_coords'] - } - clsf_dict = { 'trained RF': clsf, 'features': featset, 'CV summary': CV_summary, - 'training dataset': train_info } # save pickle with trained classifier and other info From 06e480b8c7baaa57fe02335690744f634d4d00d2 Mon Sep 17 00:00:00 2001 From: luponzo86 Date: Sun, 13 Oct 2019 16:56:40 -0700 Subject: [PATCH 09/24] resetTimestamp --- rhapsody/features/PDB.py | 3 +++ rhapsody/features/Uniprot.py | 13 ++++++++----- test/test-2/test-2.py | 10 +++++++--- 3 files changed, 18 insertions(+), 8 deletions(-) diff --git a/rhapsody/features/PDB.py b/rhapsody/features/PDB.py index af016fc..9000783 100644 --- a/rhapsody/features/PDB.py +++ b/rhapsody/features/PDB.py @@ -209,6 +209,9 @@ def savePickle(self, folder=None, filename=None): LOGGER.info("Pickle '{}' saved.".format(filename)) return pickle_path + def resetTimestamp(self): + self.timestamp = str(datetime.datetime.utcnow()) + def setNumModes(self, n_modes): """Sets the number of ENM modes to be computed. If different from the number provided at instantiation, any precomputed features will diff --git a/rhapsody/features/Uniprot.py b/rhapsody/features/Uniprot.py index 392b3f1..79d8046 100644 --- a/rhapsody/features/Uniprot.py +++ b/rhapsody/features/Uniprot.py @@ -28,7 +28,7 @@ def __init__(self, acc, recover_pickle=False, **kwargs): self.customPDBmappings = None self._align_algo_args = None self._align_algo_kwargs = None - self._timestamp = None + self.timestamp = None self.Pfam = None assert type(recover_pickle) is bool if recover_pickle: @@ -58,7 +58,7 @@ def refresh(self): self.customPDBmappings = [] self._align_algo_args = ['localxs', -0.5, -0.1] self._align_algo_kwargs = {'one_alignment_only': True} - self._timestamp = str(datetime.datetime.utcnow()) + self.timestamp = str(datetime.datetime.utcnow()) self.Pfam = None return @@ -401,7 +401,7 @@ def recoverPickle(self, filename=None, folder=None, days=30, **kwargs): % recovered_self.uniq_acc + 'does not match.') # check timestamp and ignore pickles that are too old date_format = "%Y-%m-%d %H:%M:%S.%f" - t_old = datetime.datetime.strptime(recovered_self._timestamp, + t_old = datetime.datetime.strptime(recovered_self.timestamp, date_format) t_now = datetime.datetime.utcnow() Delta_t = datetime.timedelta(days=days) @@ -416,11 +416,14 @@ def recoverPickle(self, filename=None, folder=None, days=30, **kwargs): self.customPDBmappings = recovered_self.customPDBmappings self._align_algo_args = recovered_self._align_algo_args self._align_algo_kwargs = recovered_self._align_algo_kwargs - self._timestamp = recovered_self._timestamp + self.timestamp = recovered_self.timestamp self.Pfam = recovered_self.Pfam LOGGER.info("Pickle '{}' recovered.".format(filename)) return + def resetTimestamp(self): + self.timestamp = str(datetime.datetime.utcnow()) + def _checkAccessionNumber(self, acc): if '-' in acc: acc = acc.split('-')[0] @@ -439,7 +442,7 @@ def _parseSelString(self, sel_str): resids = fields[1].split('-') try: resids = tuple([int(s) for s in resids]) - except: + except Exception: # sometimes the interval is undefined, # e.g. "A=-" resids = None diff --git a/test/test-2/test-2.py b/test/test-2/test-2.py index 54aa11c..5f2c785 100644 --- a/test/test-2/test-2.py +++ b/test/test-2/test-2.py @@ -1,6 +1,6 @@ import sys import os -import shutil +import pickle import prody as pd # check if rhapsody can be imported correctly @@ -15,8 +15,12 @@ # train classifiers rd.initialSetup(download_EVmutation=False) -shutil.copyfile('./data/UniprotMap-P01112.pkl', - './workspace/pickles/UniprotMap-P01112.pkl') + +# recover pickle and reset timestamp +with open('./data/UniprotMap-P01112.pkl', 'rb') as f: + p = pickle.load(f) + p.resetTimestamp() + p.savePickle() # let's run a saturation mutagenesis test with a custom PDB structure os.chdir('workspace') From 5e2074bdf4a303cbf62a3208b8572ba5d8a0d23a Mon Sep 17 00:00:00 2001 From: luponzo86 Date: Fri, 18 Oct 2019 19:28:44 -0700 Subject: [PATCH 10/24] add calcClassMetrics and error bars to metrics --- rhapsody/train/RFtraining.py | 102 ++++++++++++++++++++++++----------- rhapsody/train/figures.py | 6 +-- rhapsody/utils/settings.py | 2 +- 3 files changed, 74 insertions(+), 36 deletions(-) diff --git a/rhapsody/train/RFtraining.py b/rhapsody/train/RFtraining.py index 1cdc9bc..58a52fd 100644 --- a/rhapsody/train/RFtraining.py +++ b/rhapsody/train/RFtraining.py @@ -9,31 +9,58 @@ from prody import LOGGER from sklearn.model_selection import StratifiedKFold from sklearn.ensemble import RandomForestClassifier -from sklearn.metrics import roc_curve, roc_auc_score, auc +from sklearn.metrics import roc_curve, roc_auc_score from sklearn.metrics import precision_recall_curve, average_precision_score +from sklearn.metrics import matthews_corrcoef, precision_recall_fscore_support from ..utils.settings import DEFAULT_FEATSETS, getDefaultTrainingDataset from .figures import print_pred_distrib_figure, print_path_prob_figure from .figures import print_ROC_figure, print_feat_imp_figure -__all__ = ['calcMetrics', 'calcPathogenicityProbs', 'RandomForestCV', - 'trainRFclassifier', 'extendDefaultTrainingDataset'] +__all__ = ['calcScoreMetrics', 'calcClassMetrics', 'calcPathogenicityProbs', + 'RandomForestCV', 'trainRFclassifier', + 'extendDefaultTrainingDataset'] -def calcMetrics(y_test, y_pred): +def calcScoreMetrics(y_test, y_pred): # compute ROC and AUROC fpr, tpr, roc_thr = roc_curve(y_test, y_pred) + roc = {'FPR': fpr, 'TPR': tpr, 'thresholds': roc_thr} auroc = roc_auc_score(y_test, y_pred) # compute optimal cutoff J (argmax of Youden's index) diff = np.array([y-x for x, y in zip(fpr, tpr)]) Jopt = roc_thr[(-diff).argsort()][0] # compute Precision-Recall curve and AUPRC pre, rec, prc_thr = precision_recall_curve(y_test, y_pred) + prc = {'precision': pre, 'recall': rec, 'thresholds': prc_thr} auprc = average_precision_score(y_test, y_pred) - return {'FPR': fpr, 'TPR': tpr, 'ROC_thresholds': roc_thr, - 'AUROC': auroc, 'optimal cutoff': Jopt, - 'precision': pre, 'recall': rec, 'PRC_thresholds': prc_thr, - 'AUPRC': auprc} + output = { + 'ROC': roc, + 'AUROC': auroc, + 'optimal cutoff': Jopt, + 'PRC': prc, + 'AUPRC': auprc + } + return output + + +def calcClassMetrics(y_test, y_pred): + mcc = matthews_corrcoef(y_test, y_pred) + pre, rec, f1s, sup = precision_recall_fscore_support( + y_test, y_pred, labels=[0, 1]) + avg_pre, avg_rec, avg_f1s, _ = precision_recall_fscore_support( + y_test, y_pred, average='weighted') + output = { + 'MCC': mcc, + 'precision': pre, + 'recall': rec, + 'F1 score': f1s, + 'support': sup, + 'average precision': avg_pre, + 'average recall': avg_rec, + 'average F1 score': avg_f1s + } + return output def calcPathogenicityProbs(CV_info, num_bins=15, @@ -44,7 +71,7 @@ def calcPathogenicityProbs(CV_info, num_bins=15, from predictions on CV test sets ''' - avg_Jopt = np.mean(CV_info['Youden_cutoff']) + mean_Jopt = np.mean(CV_info['Youden_cutoff']) preds = [np.array(CV_info['predictions_0']), np.array(CV_info['predictions_1'])] @@ -61,7 +88,7 @@ def calcPathogenicityProbs(CV_info, num_bins=15, # print predictions distribution figure if pred_distrib_fig is not None: print_pred_distrib_figure(pred_distrib_fig, bins, norm_histo, - dx, avg_Jopt) + dx, mean_Jopt) # compute pathogenicity probability s = np.sum(norm_histo, axis=0) @@ -164,12 +191,12 @@ def _performCV(X, y, sel_SAVs, n_estimators=1000, max_features='auto', # calculate probabilities over decision trees y_pred = classifier.predict_proba(X_test) # compute ROC, AUROC, optimal cutoff (argmax of Youden's index), etc... - d = calcMetrics(y_test, y_pred[:, 1]) + d = calcScoreMetrics(y_test, y_pred[:, 1]) auroc = d['AUROC'] auprc = d['AUPRC'] Jopt = d['optimal cutoff'] # store other info and metrics for each iteration - mean_tpr += np.interp(mean_fpr, d['FPR'], d['TPR']) + mean_tpr += np.interp(mean_fpr, d['ROC']['FPR'], d['ROC']['TPR']) oob_score = classifier.oob_score_ CV_info['AUROC'].append(auroc) CV_info['AUPRC'].append(auprc) @@ -183,41 +210,52 @@ def _performCV(X, y, sel_SAVs, n_estimators=1000, max_features='auto', LOGGER.info(f'CV iteration #{i:2d}: AUROC = {auroc:.3f} ' f'AUPRC = {auprc:.3f} OOB score = {oob_score:.3f}') - # compute average ROC, optimal cutoff and other stats + # compute average ROC curves mean_tpr /= cv.get_n_splits(X, y) mean_tpr[0] = 0.0 mean_tpr[-1] = 1.0 - mean_auroc = auc(mean_fpr, mean_tpr) - mean_auprc = np.mean(CV_info['AUPRC']) - mean_oob = np.mean(CV_info['OOB_score']) - avg_Jopt = np.mean(CV_info['Youden_cutoff']) - std_Jopt = np.std(CV_info['Youden_cutoff']) - avg_feat_imp = np.mean(np.array(CV_info['feat_importance']), axis=0) + # compute average ROC, optimal cutoff and other stats + stats = {} + for s in ['AUROC', 'AUPRC', 'OOB_score', 'Youden_cutoff']: + stats[s] = (np.mean(CV_info[s]), np.std(CV_info[s])) + stats['feat_importance'] = ( + np.mean(np.array(CV_info['feat_importance']), axis=0), + np.std(np.array(CV_info['feat_importance']), axis=0) + ) + LOGGER.info('-'*60) LOGGER.info('Cross-validation summary:') LOGGER.info(f'training dataset size: {len(y):23s}: {importance:.3f}') + feature_names = [f'feature {i}' for i in range(n_feats)] + for i, feat_name in enumerate(feature_names): + LOGGER.info('{:>23s}: {:.3f}'.format( + feat_name, stats['feat_importance'][0][i])) LOGGER.info('-'*60) + path_prob = calcPathogenicityProbs(CV_info, **kwargs) CV_summary = { 'dataset size': len(y), 'dataset bias': sum(y)/len(y), - 'mean AUROC': mean_auroc, - 'mean AUPRC': mean_auprc, - 'mean OOB score': mean_oob, 'mean ROC': list(zip(mean_fpr, mean_tpr)), - 'optimal cutoff': (avg_Jopt, std_Jopt), - 'feat. importance': avg_feat_imp, + 'mean AUROC': stats['AUROC'], + 'mean AUPRC': stats['AUPRC'], + 'mean OOB score': stats['OOB_score'], + 'optimal cutoff': stats['Youden_cutoff'], + 'feat. importances': stats['feat_importance'], 'path. probability': path_prob, 'training dataset': sel_SAVs, 'folds': CV_folds @@ -225,7 +263,7 @@ def _performCV(X, y, sel_SAVs, n_estimators=1000, max_features='auto', # plot average ROC if ROC_fig is not None: - print_ROC_figure(ROC_fig, mean_fpr, mean_tpr, mean_auroc) + print_ROC_figure(ROC_fig, mean_fpr, mean_tpr, stats['AUROC']) return CV_summary diff --git a/rhapsody/train/figures.py b/rhapsody/train/figures.py index feaff2b..4ea3ecc 100644 --- a/rhapsody/train/figures.py +++ b/rhapsody/train/figures.py @@ -76,7 +76,7 @@ def print_path_prob_figure(filename, bins, histo, dx, path_prob, LOGGER.info(f'Pathogenicity plot saved to {filename}') -def print_ROC_figure(filename, fpr, tpr, mean_auc): +def print_ROC_figure(filename, fpr, tpr, auc_stat): assert isinstance(filename, str), 'filename must be a string' filename = os.path.splitext(filename)[0] + '.png' @@ -89,12 +89,12 @@ def print_ROC_figure(filename, fpr, tpr, mean_auc): fig = plt.figure(figsize=(7, 7)) plt.plot([0, 1], [0, 1], linestyle='--', lw=1, color='k') plt.plot(fpr, tpr, linestyle='-', lw=2, color='r', - label=f'Mean AUROC = {mean_auc:.3f}') + label='AUROC = {:.3f} +/- {:.3f}'.format(*auc_stat)) plt.xlim([-0.05, 1.05]) plt.ylim([-0.05, 1.05]) plt.xlabel('False Positive Rate') plt.ylabel('True Positive Rate') - plt.title('Receiver operating characteristic') + plt.title('mean ROC curve from cross-validation') plt.legend(loc="lower right") fig.savefig(filename, format='png', bbox_inches='tight') plt.close() diff --git a/rhapsody/utils/settings.py b/rhapsody/utils/settings.py index fbed36e..1e9a2c0 100644 --- a/rhapsody/utils/settings.py +++ b/rhapsody/utils/settings.py @@ -155,7 +155,7 @@ def initialSetup(working_dir=None, refresh=False, download_EVmutation=True): # NB: EVmutation score and pathogenicity are anti-correlated true_labels = training_dataset['true_label'][sel] EVmut_predictor = -training_dataset['EVmut-DeltaE_epist'][sel] - metrics = rd.calcMetrics(true_labels, EVmut_predictor) + metrics = rd.calcScoreMetrics(true_labels, EVmut_predictor) pd.SETTINGS['EVmutation_metrics'] = metrics pd.LOGGER.info(f'EVmutation metrics computed.') From 2cc2dfc000973d40e6ba664f2035e67f404ee5df Mon Sep 17 00:00:00 2001 From: luponzo86 Date: Sun, 20 Oct 2019 19:26:03 -0700 Subject: [PATCH 11/24] - --- rhapsody/features/EVmutation.py | 11 ++- rhapsody/predict/core.py | 4 +- rhapsody/train/RFtraining.py | 139 +++++++++++++++++--------------- 3 files changed, 84 insertions(+), 70 deletions(-) diff --git a/rhapsody/features/EVmutation.py b/rhapsody/features/EVmutation.py index be8ba50..1a3f90f 100644 --- a/rhapsody/features/EVmutation.py +++ b/rhapsody/features/EVmutation.py @@ -70,8 +70,8 @@ def find_matching_files(file_list, acc, pos): with open(join(EVmut_dir, fname), 'r') as f: for line in f: if line.startswith(mutant): - l = line.strip().split(';')[4:8] - data.append(l) + ll = line.strip().split(';')[4:8] + data.append(ll) break data = np.array(data, dtype=float) if len(data) == 0: @@ -82,3 +82,10 @@ def find_matching_files(file_list, acc, pos): LOGGER.report('EVmutation scores recovered in %.1fs.', '_EVmut') return features + + +def calcEVmutPathClasses(EVmut_score): + c = -SETTINGS.get('EVmutation_metrics')['optimal cutoff'] + EVmut_class = np.where(EVmut_score < c, 'deleterious', 'neutral') + EVmut_class[np.isnan(EVmut_score)] = '?' + return EVmut_class diff --git a/rhapsody/predict/core.py b/rhapsody/predict/core.py index 5d33ecb..008c17c 100644 --- a/rhapsody/predict/core.py +++ b/rhapsody/predict/core.py @@ -569,9 +569,7 @@ def _calcEVmutationPredictions(self): return EVmut_feats = EVmutation.recoverEVmutFeatures(self.data['SAV coords']) EVmut_score = EVmut_feats['EVmut-DeltaE_epist'] - c = -SETTINGS.get('EVmutation_metrics')['optimal cutoff'] - EVmut_class = np.where(EVmut_score < c, 'deleterious', 'neutral') - EVmut_class[np.isnan(EVmut_score)] = '?' + EVmut_class = EVmutation.calcEVmutPathClasses(EVmut_score) self.data['EVmutation score'] = EVmut_score self.data['EVmutation path. class'] = EVmut_class diff --git a/rhapsody/train/RFtraining.py b/rhapsody/train/RFtraining.py index 58a52fd..4fde02d 100644 --- a/rhapsody/train/RFtraining.py +++ b/rhapsody/train/RFtraining.py @@ -52,13 +52,15 @@ def calcClassMetrics(y_test, y_pred): y_test, y_pred, average='weighted') output = { 'MCC': mcc, - 'precision': pre, - 'recall': rec, - 'F1 score': f1s, - 'support': sup, - 'average precision': avg_pre, - 'average recall': avg_rec, - 'average F1 score': avg_f1s + 'precision (0)': pre[0], + 'recall (0)': rec[0], + 'F1 score (0)': f1s[0], + 'precision (1)': pre[1], + 'recall (1)': rec[1], + 'F1 score (1)': f1s[1], + 'precision': avg_pre, + 'recall': avg_rec, + 'F1 score': avg_f1s } return output @@ -71,7 +73,7 @@ def calcPathogenicityProbs(CV_info, num_bins=15, from predictions on CV test sets ''' - mean_Jopt = np.mean(CV_info['Youden_cutoff']) + mean_Jopt = np.mean(CV_info['optimal cutoff']) preds = [np.array(CV_info['predictions_0']), np.array(CV_info['predictions_1'])] @@ -104,9 +106,9 @@ def calcPathogenicityProbs(CV_info, num_bins=15, # print pathogenicity probability figure if path_prob_fig is not None: - print_path_prob_figure(path_prob_fig, bins, histo, dx, path_prob, - smooth_plot=smooth_path_prob, - cutoff=ppred_reliability_cutoff) + print_path_prob_figure( + path_prob_fig, bins, histo, dx, path_prob, + smooth_plot=smooth_path_prob, cutoff=ppred_reliability_cutoff) return np.array(smooth_path_prob) @@ -135,7 +137,9 @@ def _calcSmoothCurve(curve, smooth_window): def _performCV(X, y, sel_SAVs, n_estimators=1000, max_features='auto', n_splits=10, ROC_fig='ROC.png', feature_names=None, - CVseed=666, protein_stratification=False, **kwargs): + CVseed=666, stratification=None, **kwargs): + + assert stratification in [None, 'protein', 'residue'] # set classifier classifier = RandomForestClassifier( @@ -150,10 +154,16 @@ def _performCV(X, y, sel_SAVs, n_estimators=1000, max_features='auto', # protein-stratification: a same protein should not be found in # both training and test sets - if protein_stratification: - # for each fold, count occurrences of each accession number + if stratification is not None: + # for each fold, count occurrences of each protein/residue occurrences = {} - accs = np.array([s.split()[0] for s in sel_SAVs['SAV_coords']]) + if stratification == 'protein': + # e.g. 'P01112' + accs = np.array([s.split()[0] for s in sel_SAVs['SAV_coords']]) + else: + # e.g. P01112 99 + accs = np.array([' '.join(s.split()[:2]) + for s in sel_SAVs['SAV_coords']]) for k, (train, test) in enumerate(CV_folds): counts = Counter(accs[test]) for acc, count in counts.items(): @@ -168,17 +178,14 @@ def _performCV(X, y, sel_SAVs, n_estimators=1000, max_features='auto', CV_folds[k][1] = np.where(new_folds == k)[0] # cross-validation loop - CV_info = { - 'AUROC': [], - 'AUPRC': [], - 'feat_importance': [], - 'OOB_score': [], - 'Youden_cutoff': [], - 'predictions_0': [], - 'predictions_1': [] - } + CV_info = {k: [] for k in [ + 'AUROC', 'AUPRC', 'OOB score', 'optimal cutoff', 'MCC', + 'precision (0)', 'recall (0)', 'F1 score (0)', + 'precision (1)', 'recall (1)', 'F1 score (1)', + 'precision', 'recall', 'F1 score', + 'feat. importances', 'predictions_0', 'predictions_1']} mean_tpr = 0.0 - mean_fpr = np.linspace(0, 1, 100) + mean_fpr = np.linspace(0, 1, 20) i = 0 for train, test in CV_folds: # create training and test datasets @@ -189,26 +196,30 @@ def _performCV(X, y, sel_SAVs, n_estimators=1000, max_features='auto', # train Random Forest classifier classifier.fit(X_train, y_train) # calculate probabilities over decision trees - y_pred = classifier.predict_proba(X_test) - # compute ROC, AUROC, optimal cutoff (argmax of Youden's index), etc... - d = calcScoreMetrics(y_test, y_pred[:, 1]) - auroc = d['AUROC'] - auprc = d['AUPRC'] - Jopt = d['optimal cutoff'] - # store other info and metrics for each iteration - mean_tpr += np.interp(mean_fpr, d['ROC']['FPR'], d['ROC']['TPR']) - oob_score = classifier.oob_score_ - CV_info['AUROC'].append(auroc) - CV_info['AUPRC'].append(auprc) - CV_info['feat_importance'].append(classifier.feature_importances_) - CV_info['OOB_score'].append(oob_score) - CV_info['Youden_cutoff'].append(Jopt) - CV_info['predictions_0'].extend(y_pred[np.where(y_test == 0), 1][0]) - CV_info['predictions_1'].extend(y_pred[np.where(y_test == 1), 1][0]) + y_pred = classifier.predict_proba(X_test)[:, 1] + + # compute ROC, AUROC, optimal cutoff (argmax of Youden's index), etc. + sm = calcScoreMetrics(y_test, y_pred) + for stat in ['AUROC', 'AUPRC', 'optimal cutoff']: + CV_info[stat].append(sm[stat]) + # compute Matthews corr. coeff., precision/recall, etc. on classes + y_pred_binary = np.where(y_pred > sm['optimal cutoff'], 1, 0) + cm = calcClassMetrics(y_test, y_pred_binary) + for stat in cm.keys(): + CV_info[stat].append(cm[stat]) + # other info + mean_tpr += np.interp(mean_fpr, sm['ROC']['FPR'], sm['ROC']['TPR']) + CV_info['OOB score'].append(classifier.oob_score_) + CV_info['feat. importances'].append( + np.array(classifier.feature_importances_)) + CV_info['predictions_0'].extend(y_pred[y_test == 0]) + CV_info['predictions_1'].extend(y_pred[y_test == 1]) # print log i += 1 - LOGGER.info(f'CV iteration #{i:2d}: AUROC = {auroc:.3f} ' - f'AUPRC = {auprc:.3f} OOB score = {oob_score:.3f}') + LOGGER.info('CV iteration #{:2d}: '.format(i) + + 'AUROC = {:.3f} '.format(sm['AUROC']) + + 'AUPRC = {:.3f} '.format(sm['AUPRC']) + + 'OOB score = {:.3f}'.format(classifier.oob_score_)) # compute average ROC curves mean_tpr /= cv.get_n_splits(X, y) @@ -216,34 +227,30 @@ def _performCV(X, y, sel_SAVs, n_estimators=1000, max_features='auto', mean_tpr[-1] = 1.0 # compute average ROC, optimal cutoff and other stats stats = {} - for s in ['AUROC', 'AUPRC', 'OOB_score', 'Youden_cutoff']: - stats[s] = (np.mean(CV_info[s]), np.std(CV_info[s])) - stats['feat_importance'] = ( - np.mean(np.array(CV_info['feat_importance']), axis=0), - np.std(np.array(CV_info['feat_importance']), axis=0) - ) + for s in CV_info.keys(): + if s in ['predictions_0', 'predictions_1']: + continue + stats[s] = (np.mean(CV_info[s], axis=0), np.std(CV_info[s], axis=0)) LOGGER.info('-'*60) LOGGER.info('Cross-validation summary:') LOGGER.info(f'training dataset size: {len(y):23s}: {:.3f}'.format( - feat_name, stats['feat_importance'][0][i])) + feat_name, stats['feat. importances'][0][i])) LOGGER.info('-'*60) path_prob = calcPathogenicityProbs(CV_info, **kwargs) @@ -251,15 +258,17 @@ def _performCV(X, y, sel_SAVs, n_estimators=1000, max_features='auto', 'dataset size': len(y), 'dataset bias': sum(y)/len(y), 'mean ROC': list(zip(mean_fpr, mean_tpr)), - 'mean AUROC': stats['AUROC'], - 'mean AUPRC': stats['AUPRC'], - 'mean OOB score': stats['OOB_score'], - 'optimal cutoff': stats['Youden_cutoff'], - 'feat. importances': stats['feat_importance'], + 'optimal cutoff': stats['optimal cutoff'], + 'feat. importances': stats['feat. importances'], 'path. probability': path_prob, 'training dataset': sel_SAVs, 'folds': CV_folds } + for s in ['AUROC', 'AUPRC', 'OOB score', 'MCC', + 'precision (0)', 'recall (0)', 'F1 score (0)', + 'precision (1)', 'recall (1)', 'F1 score (1)', + 'precision', 'recall', 'F1 score']: + CV_summary['mean ' + s] = stats[s] # plot average ROC if ROC_fig is not None: From a8a34af0d2e36497ad5172c55b9d2ff92fd7c31c Mon Sep 17 00:00:00 2001 From: luponzo86 Date: Sat, 2 Nov 2019 19:25:14 -0700 Subject: [PATCH 12/24] add importDefaultClassifier() --- rhapsody/utils/settings.py | 15 ++++++++++++++- 1 file changed, 14 insertions(+), 1 deletion(-) diff --git a/rhapsody/utils/settings.py b/rhapsody/utils/settings.py index 1e9a2c0..3df3632 100644 --- a/rhapsody/utils/settings.py +++ b/rhapsody/utils/settings.py @@ -4,6 +4,7 @@ import os import tarfile +import pickle import urllib.request import shutil import sklearn @@ -13,7 +14,7 @@ __all__ = ['DEFAULT_FEATSETS', 'initialSetup', 'getDefaultTrainingDataset', 'getDefaultClassifiers', - 'delSettings', 'getSettings'] + 'importDefaultClassifier', 'delSettings', 'getSettings'] USERHOME = os.getenv('USERPROFILE') or os.getenv('HOME') or './' DEFAULT_WORKING_DIR = os.path.join(USERHOME, 'rhapsody') @@ -232,6 +233,18 @@ def getDefaultClassifiers(): return def_clsfs +def importDefaultClassifier(version): + """Imports the specified classifier and its summary + + :arg version: either 'full', 'reduced' or 'EVmut' + :type version: str + """ + assert version in ['full', 'reduced', 'EVmut'] + with open(getDefaultClassifiers()[version], 'rb') as p: + clsf = pickle.load(p) + return clsf + + def delSettings(): for entry in ['rhapsody_local_folder', 'rhapsody_training_dataset', 'EVmutation_local_folder', 'EVmutation_metrics']: From 050ea7b1a4f8d69f293ac6d6a790eabc69f0300f Mon Sep 17 00:00:00 2001 From: luponzo86 Date: Thu, 14 Nov 2019 12:46:35 -0800 Subject: [PATCH 13/24] add tqdm progress bars to main loops --- rhapsody/features/PDB.py | 40 +++-- rhapsody/features/Pfam.py | 25 +++- rhapsody/features/Uniprot.py | 34 ++++- rhapsody/predict/core.py | 24 ++- rhapsody/predict/main.py | 10 +- rhapsody/utils/misc.py | 283 +++++++++++++++++++++++++++++++++++ 6 files changed, 388 insertions(+), 28 deletions(-) create mode 100644 rhapsody/utils/misc.py diff --git a/rhapsody/features/PDB.py b/rhapsody/features/PDB.py index 9000783..4d8b27e 100644 --- a/rhapsody/features/PDB.py +++ b/rhapsody/features/PDB.py @@ -3,16 +3,18 @@ PDB-based structural and dynamical features in a single place, and a function for using the latter on a list of PDB SAV coordinates.""" +import numpy as np +import pickle +import datetime +import os +from tqdm import tqdm from prody import Atomic, parsePDB, writePDB, LOGGER, SETTINGS from prody import GNM, ANM, calcSqFlucts from prody import calcPerturbResponse, calcMechStiff # from prody import calcMBS from prody import reduceModel, sliceModel from prody import execDSSP, parseDSSP -import numpy as np -import pickle -import datetime -import os + __all__ = ['STR_FEATS', 'DYN_FEATS', 'PDB_FEATS', 'PDBfeatures', 'calcPDBfeatures'] @@ -646,7 +648,7 @@ def calcSelFeatures(self, chain='all', resid=None, sel_feats=None): def calcPDBfeatures(mapped_SAVs, sel_feats=None, custom_PDB=None, - refresh=False): + refresh=False, status_file=None, status_prefix=None): LOGGER.info('Computing structural and dynamical features ' 'from PDB structures...') LOGGER.timeit('_calcPDBFeats') @@ -665,24 +667,40 @@ def calcPDBfeatures(mapped_SAVs, sel_feats=None, custom_PDB=None, else: # no need to sort when using a custom PDB or PDBID sorting_map = range(num_SAVs) + # define how to report progress + if status_prefix is None: + status_prefix = '' + bar_format = '{l_bar}{bar}| {n_fmt}/{total_fmt} [{elapsed}<{remaining}]' + if status_file is not None: + status_file = open(status_file, 'w') + progress_bar = tqdm( + [(i, mapped_SAVs[i]) for i in sorting_map], file=status_file, + bar_format=bar_format+'\n') + else: + progress_bar = tqdm( + [(i, mapped_SAVs[i]) for i in sorting_map], bar_format=bar_format) cache = {'PDBID': None, 'chain': None, 'obj': None} count = 0 - for indx, SAV in [(i, mapped_SAVs[i]) for i in sorting_map]: + for indx, SAV in progress_bar: count += 1 if SAV['PDB size'] == 0: # SAV could not be mapped to PDB _features = np.nan SAV_coords = SAV['SAV coords'] - LOGGER.info(f"[{count}/{num_SAVs}] SAV '{SAV_coords}' " - "couldn't be mapped to PDB") + progress_msg = f"{status_prefix}No PDB for SAV '{SAV_coords}'" else: parsed_PDB_coords = SAV['PDB SAV coords'].split() PDBID, chID = parsed_PDB_coords[:2] resid = int(parsed_PDB_coords[2]) - LOGGER.info("[{}/{}] Analizing mutation site {}:{} {}..." - .format(count, num_SAVs, PDBID, chID, resid)) + progress_msg = status_prefix + \ + f'Analizing mutation site {PDBID}:{chID} {resid}' # chID == "?" stands for "empty space" chID = " " if chID == "?" else chID + # report progress + # LOGGER.info(f"[{count}/{num_SAVs}] {progress_msg}...") + progress_bar.set_description(progress_msg) + # compute PDB features, if possible + if SAV['PDB size'] != 0: if PDBID == cache['PDBID']: # use PDBfeatures instance from previous iteration obj = cache['obj'] @@ -728,4 +746,6 @@ def calcPDBfeatures(mapped_SAVs, sel_feats=None, custom_PDB=None, and custom_PDB is None: cache['obj'].savePickle() LOGGER.report('PDB features have been computed in %.1fs.', '_calcPDBFeats') + if status_file: + os.remove(status_file.name) return features diff --git a/rhapsody/features/Pfam.py b/rhapsody/features/Pfam.py index 091b9ac..57117e5 100644 --- a/rhapsody/features/Pfam.py +++ b/rhapsody/features/Pfam.py @@ -3,7 +3,9 @@ coevolution properties of an amino acid substitution from a Pfam multiple sequence alignment.""" +import os import numpy as np +from tqdm import tqdm from prody import LOGGER from .Uniprot import UniprotMapping @@ -38,7 +40,7 @@ def calcNormRank(array, i): return feats -def calcPfamFeatures(SAVs): +def calcPfamFeatures(SAVs, status_file=None, status_prefix=None): LOGGER.info('Computing sequence properties from Pfam domains...') LOGGER.timeit('_calcPfamFeats') # sort SAVs, so to group together those @@ -49,14 +51,29 @@ def calcPfamFeatures(SAVs): num_SAVs = len(SAVs) feat_dtype = np.dtype([('entropy', 'f'), ('ranked_MI', 'f')]) features = np.zeros(num_SAVs, dtype=feat_dtype) + # define how to report progress + if status_prefix is None: + status_prefix = '' + bar_format = '{l_bar}{bar}| {n_fmt}/{total_fmt} [{elapsed}<{remaining}]' + if status_file is not None: + status_file = open(status_file, 'w') + progress_bar = tqdm( + [(i, SAVs[i]) for i in sorting_map], file=status_file, + bar_format=bar_format+'\n') + else: + progress_bar = tqdm( + [(i, SAVs[i]) for i in sorting_map], bar_format=bar_format) # map to Pfam domains using UniprotMapping class cache = {'acc': None, 'obj': None, 'warn': ''} count = 0 - for indx, SAV in [(i, SAVs[i]) for i in sorting_map]: + for indx, SAV in progress_bar: count += 1 acc, pos, aa1, aa2 = SAV.split() pos = int(pos) - LOGGER.info(f"[{count}/{num_SAVs}] Mapping SAV '{SAV}' to Pfam...") + # report progress + progress_msg = f"{status_prefix}Mapping SAV '{SAV}' to Pfam" + # LOGGER.info(f"[{count}/{num_SAVs}] {progress_msg}...") + progress_bar.set_description(progress_msg) # map to Pfam domains using 'UniprotMapping' class if acc == cache['acc']: # use object from previous iteration @@ -102,4 +119,6 @@ def calcPfamFeatures(SAVs): cache['obj'].savePickle() LOGGER.report('SAVs have been mapped on Pfam domains and sequence ' 'properties have been computed in %.1fs.', '_calcPfamFeats') + if status_file: + os.remove(status_file.name) return features diff --git a/rhapsody/features/Uniprot.py b/rhapsody/features/Uniprot.py index 79d8046..83b8dc0 100644 --- a/rhapsody/features/Uniprot.py +++ b/rhapsody/features/Uniprot.py @@ -9,6 +9,7 @@ import numpy as np import prody as pd from prody import LOGGER, SETTINGS +from tqdm import tqdm from Bio.pairwise2 import align as bioalign from Bio.pairwise2 import format_alignment from Bio.SubsMat import MatrixInfo as matlist @@ -758,7 +759,8 @@ def calcEvolProperties(self, resid='all', refresh=False, folder=None, return {k: self.Pfam[k] for k in PF_list} -def mapSAVs2PDB(SAV_coords, custom_PDB=None, refresh=False): +def mapSAVs2PDB(SAV_coords, custom_PDB=None, refresh=False, + status_file=None, status_prefix=None): LOGGER.info('Mapping SAVs to PDB structures...') LOGGER.timeit('_map2PDB') # sort SAVs, so to group together those @@ -766,20 +768,36 @@ def mapSAVs2PDB(SAV_coords, custom_PDB=None, refresh=False): accs = [s.split()[0] for s in SAV_coords] sorting_map = np.argsort(accs) # define a structured array - PDBmap_dtype = np.dtype([('orig. SAV coords', 'U25'), - ('unique SAV coords', 'U25'), - ('PDB SAV coords', 'U100'), - ('PDB size', 'i')]) + PDBmap_dtype = np.dtype([ + ('orig. SAV coords', 'U25'), + ('unique SAV coords', 'U25'), + ('PDB SAV coords', 'U100'), + ('PDB size', 'i')]) nSAVs = len(SAV_coords) mapped_SAVs = np.zeros(nSAVs, dtype=PDBmap_dtype) + # define how to report progress + if status_prefix is None: + status_prefix = '' + bar_format = '{l_bar}{bar}| {n_fmt}/{total_fmt} [{elapsed}<{remaining}]' + if status_file is not None: + status_file = open(status_file, 'w') + progress_bar = tqdm( + [(i, SAV_coords[i]) for i in sorting_map], file=status_file, + bar_format=bar_format+'\n') + else: + progress_bar = tqdm( + [(i, SAV_coords[i]) for i in sorting_map], bar_format=bar_format) # map to PDB using Uniprot class cache = {'acc': None, 'obj': None} count = 0 - for indx, SAV in [(i, SAV_coords[i]) for i in sorting_map]: + for indx, SAV in progress_bar: count += 1 acc, pos, aa1, aa2 = SAV.split() pos = int(pos) - LOGGER.info(f"[{count}/{nSAVs}] Mapping SAV '{SAV}' to PDB...") + # report progress + progress_msg = f"{status_prefix}Mapping SAV '{SAV}' to PDB" + # LOGGER.info(f"[{count}/{nSAVs}] {progress_msg}...") + progress_bar.set_description(progress_msg) # map Uniprot to PDB chains if acc == cache['acc']: # use mapping from previous iteration @@ -836,6 +854,8 @@ def mapSAVs2PDB(SAV_coords, custom_PDB=None, refresh=False): n = sum(mapped_SAVs['PDB size'] != 0) LOGGER.report(f'{n} out of {nSAVs} SAVs have been mapped to PDB in %.1fs.', '_map2PDB') + if status_file: + os.remove(status_file.name) return mapped_SAVs diff --git a/rhapsody/predict/core.py b/rhapsody/predict/core.py index 008c17c..b3f03bf 100644 --- a/rhapsody/predict/core.py +++ b/rhapsody/predict/core.py @@ -22,7 +22,8 @@ class Rhapsody: EVmutation. """ - def __init__(self, query=None, query_type='SAVs', queryPolyPhen2=True): + def __init__(self, query=None, query_type='SAVs', queryPolyPhen2=True, + **kwargs): """ Initialize a Rhapsody object with a list of SAVs (optional). :arg query: Single Amino Acid Variants (SAVs) in Uniprot coordinates. @@ -53,6 +54,14 @@ def __init__(self, query=None, query_type='SAVs', queryPolyPhen2=True): assert query_type in ('SAVs', 'PolyPhen2') assert isinstance(queryPolyPhen2, bool) + valid_kwargs = [ + 'status_file_Uniprot', + 'status_file_PDB', + 'status_file_Pfam', + 'status_prefix_Uniprot', + 'status_prefix_PDB', + 'status_prefix_Pfam'] + assert all([k in valid_kwargs for k in kwargs]) # masked NumPy array that will contain all info abut SAVs self.data = None @@ -103,6 +112,8 @@ def __init__(self, query=None, query_type='SAVs', queryPolyPhen2=True): self.classifier = None self.aux_classifier = None self.featSet = None + # options + self.options = kwargs if query is None: # a SAV list can be uploaded later with setSAVs() @@ -283,6 +294,8 @@ def getUniprot2PDBmap(self, filename='rhapsody-Uniprot2PDB.txt', # compute mapping m = Uniprot.mapSAVs2PDB( self.data['SAV coords'], custom_PDB=self.customPDB, + status_file=self.options.get('status_file_Uniprot'), + status_prefix=self.options.get('status_prefix_Uniprot'), refresh=refresh) self.data['unique SAV coords'] = m['unique SAV coords'] self.data['PDB SAV coords'] = m['PDB SAV coords'] @@ -403,7 +416,9 @@ def _calcFeatMatrix(self, refresh=False): # compute structural and dynamical features from a PDB structure f = PDB.calcPDBfeatures( Uniprot2PDBmap, sel_feats=sel_PDBfeats, - custom_PDB=self.customPDB, refresh=refresh) + custom_PDB=self.customPDB, refresh=refresh, + status_file=self.options.get('status_file_PDB'), + status_prefix=self.options.get('status_prefix_PDB')) all_feats.append(f) if RHAPSODY_FEATS['BLOSUM'].intersection(self.featSet): # retrieve BLOSUM values @@ -411,7 +426,10 @@ def _calcFeatMatrix(self, refresh=False): all_feats.append(f) if RHAPSODY_FEATS['Pfam'].intersection(self.featSet): # compute sequence properties from Pfam domains - f = Pfam.calcPfamFeatures(self.data['SAV coords']) + f = Pfam.calcPfamFeatures( + self.data['SAV coords'], + status_file=self.options.get('status_file_Pfam'), + status_prefix=self.options.get('status_prefix_Pfam')) all_feats.append(f) if RHAPSODY_FEATS['EVmut'].intersection(self.featSet): # recover EVmutation data diff --git a/rhapsody/predict/main.py b/rhapsody/predict/main.py index 3843f3e..22f93cd 100644 --- a/rhapsody/predict/main.py +++ b/rhapsody/predict/main.py @@ -12,7 +12,7 @@ def rhapsody(query, query_type='SAVs', main_classifier=None, aux_classifier=None, custom_PDB=None, force_env=None, - refresh=False, log=True): + refresh=False, log=True, **kwargs): """Obtain Rhapsody pathogenicity predictions on a list of human missense variants ([ref]_) @@ -77,7 +77,7 @@ def rhapsody(query, query_type='SAVs', aux_classifier = getDefaultClassifiers()['reduced'] # initialize object that will contain all results and predictions - r = Rhapsody() + r = Rhapsody(**kwargs) # import classifiers and feature set from pickle r.importClassifiers(main_classifier, aux_classifier, force_env=force_env) @@ -99,9 +99,9 @@ def rhapsody(query, query_type='SAVs', r.printPredictions() if aux_classifier is not None: # print both 'full' and 'reduced' predictions in a more detailed format - r.printPredictions(classifier="both", - PolyPhen2=False, EVmutation=False, - filename='rhapsody-predictions-full_vs_reduced.txt') + r.printPredictions( + classifier="both", PolyPhen2=False, EVmutation=False, + filename='rhapsody-predictions-full_vs_reduced.txt') # save pickle r.savePickle() diff --git a/rhapsody/utils/misc.py b/rhapsody/utils/misc.py new file mode 100644 index 0000000..3df3632 --- /dev/null +++ b/rhapsody/utils/misc.py @@ -0,0 +1,283 @@ +# -*- coding: utf-8 -*- +"""This module defines default configuration parameters and +a function for the initial setup and training of Rhapsody.""" + +import os +import tarfile +import pickle +import urllib.request +import shutil +import sklearn +import numpy as np +import prody as pd +import rhapsody as rd + +__all__ = ['DEFAULT_FEATSETS', 'initialSetup', + 'getDefaultTrainingDataset', 'getDefaultClassifiers', + 'importDefaultClassifier', 'delSettings', 'getSettings'] + +USERHOME = os.getenv('USERPROFILE') or os.getenv('HOME') or './' +DEFAULT_WORKING_DIR = os.path.join(USERHOME, 'rhapsody') +DEFAULT_EVMUT_DIR = os.path.join(DEFAULT_WORKING_DIR, + 'EVmutation_mutation_effects') +EVMUT_URL = 'https://marks.hms.harvard.edu/evmutation/data/effects.tar.gz' +PACKAGE_DATA = os.path.join(rd.__path__[0], 'data.tar.gz') +TRAINING_DATASET = 'precomputed_features-ID_opt.npy' +DEFAULT_CLSF_DIR = f'default_classifiers-sklearn_v{sklearn.__version__}' +DEFAULT_FEATSETS = { + 'full': ['wt_PSIC', 'Delta_PSIC', 'SASA', 'ANM_MSF-chain', + 'ANM_effectiveness-chain', 'ANM_sensitivity-chain', + 'stiffness-chain', 'entropy', 'ranked_MI', 'BLOSUM'], + 'reduced': ['wt_PSIC', 'Delta_PSIC', 'SASA', 'ANM_MSF-chain', + 'ANM_effectiveness-chain', 'ANM_sensitivity-chain', + 'stiffness-chain', 'BLOSUM'], + 'EVmut': ['wt_PSIC', 'Delta_PSIC', 'SASA', 'ANM_MSF-chain', + 'ANM_effectiveness-chain', 'ANM_sensitivity-chain', + 'stiffness-chain', 'entropy', 'ranked_MI', 'BLOSUM', + 'EVmut-DeltaE_epist'], +} + + +def initialSetup(working_dir=None, refresh=False, download_EVmutation=True): + """Function to be run right after installation for setting up the + environment and main parameters and for training the default classifiers. + By default, a working directory will be created in the user home directory + (:file:`~/rhapsody/`). Previous configuration data will be recovered. + Additional data from EVmutation website will be automatically downloaded + (~1.4GB). + + :arg working_dir: path to a local folder + :type working_dir: str + + :arg refresh: if **True**, previous trained classifiers will be deleted, + if found + :type refresh: bool + + :arg download_EVmutation: if **True**, precomputed EVmutation scores will + be downloaded (recommended) + :type download_EVmutation: bool + """ + + pd.LOGGER.info(f'You are running Rhapsody v{rd.__version__}') + + # set working directory + if working_dir is None: + # check pre-existing configuration + old_dir = pd.SETTINGS.get('rhapsody_local_folder') + if type(old_dir) is str and os.path.isdir(old_dir): + working_dir = old_dir + pd.LOGGER.info('Pre-existing working directory detected: ' + f'{working_dir}') + else: + # use default location and create folder if needed + working_dir = DEFAULT_WORKING_DIR + if os.path.isdir(working_dir): + raise EnvironmentError( + f"A folder named '{working_dir}' already exists. " + "Please specify another name.") + else: + os.mkdir(working_dir) + pd.LOGGER.info(f'Default working directory set: {working_dir}') + else: + working_dir = os.path.abspath(working_dir) + if os.path.isdir(working_dir): + pd.LOGGER.info(f'Working directory set: {working_dir}') + else: + raise EnvironmentError(f'Invalid working directory: {working_dir}') + pd.SETTINGS['rhapsody_local_folder'] = working_dir + + # create pickles folder + folder = os.path.join(working_dir, 'pickles') + if not os.path.isdir(folder): + os.mkdir(folder) + + # check for pre-existing folder containing trained classifiers + folder = os.path.join(working_dir, DEFAULT_CLSF_DIR) + training_dataset = None + if os.path.isdir(folder) and not refresh: + pd.LOGGER.info(f'Pre-existing classifiers found: {folder}') + # check for missing classifiers + for featset in DEFAULT_FEATSETS: + fname = os.path.join(folder, featset, 'trained_classifier.pkl') + if not os.path.isfile(fname): + raise IOError(f"Missing classifier: '{featset}'. Please " + f'delete folder {folder} and rerun setup.') + else: + # delete old classifiers and train new ones + if os.path.isdir(folder): + shutil.rmtree(folder) + os.mkdir(folder) + pd.LOGGER.info(f'Classifiers folder created: {folder}') + # delete EVmutation metrics as well, that must be updated + pd.SETTINGS.pop('EVmutation_metrics') + # import training dataset included with package + training_dataset = getDefaultTrainingDataset() + info = { + 'size': len(training_dataset), + 'fields': training_dataset.dtype.names + } + pd.SETTINGS['rhapsody_training_dataset'] = info + # train new default classifiers + pd.LOGGER.info('') + for name, featset in DEFAULT_FEATSETS.items(): + clsf_folder = os.path.join(folder, name) + os.mkdir(clsf_folder) + logfile = os.path.join(clsf_folder, 'RF_training.log') + # run training procedure + pd.LOGGER.info(f'Training {name} classifier...') + pd.LOGGER.start(logfile) + fields = ['SAV_coords', 'true_label'] + featset + rd.trainRFclassifier(training_dataset[fields]) + # move trained classifier and figures into folder + output_files = ['predictions_distribution.png', + 'pathogenicity_prob.png', + 'ROC.png', + 'feat_importances.png', + 'trained_classifier.pkl', ] + for file in output_files: + shutil.move(file, clsf_folder) + pd.LOGGER.close(logfile) + pd.LOGGER.info('') + + # check EVmutation metrics + metrics = pd.SETTINGS.get('EVmutation_metrics', default={}) + if 'AUROC' in metrics: + pd.LOGGER.info(f'Pre-existing EVmutation metrics found.') + else: + # compute EVmutation metrics from included training dataset + if training_dataset is None: + training_dataset = getDefaultTrainingDataset() + if 'EVmut-DeltaE_epist' not in training_dataset.dtype.names: + pd.SETTINGS['EVmutation_metrics'] = {} + pd.LOGGER.warn('Unable to compute EVmutation metrics: ' + 'precomputed scores not found.') + else: + sel = ~np.isnan(training_dataset['EVmut-DeltaE_epist']) + # NB: EVmutation score and pathogenicity are anti-correlated + true_labels = training_dataset['true_label'][sel] + EVmut_predictor = -training_dataset['EVmut-DeltaE_epist'][sel] + metrics = rd.calcScoreMetrics(true_labels, EVmut_predictor) + pd.SETTINGS['EVmutation_metrics'] = metrics + pd.LOGGER.info(f'EVmutation metrics computed.') + + # fetch EVmutation precomputed data, if needed + folder = pd.SETTINGS.get('EVmutation_local_folder') + if type(folder) is str and os.path.isdir(folder): + pd.LOGGER.info(f'EVmutation folder found: {folder}') + else: + folder = DEFAULT_EVMUT_DIR + if os.path.isdir(DEFAULT_EVMUT_DIR): + pd.LOGGER.info(f'EVmutation folder found: {folder}') + elif download_EVmutation: + pd.LOGGER.info(f'Downloading EVmutation data...') + # download tar.gz file and save it locally + tgz = os.path.join(working_dir, 'effects.tar.gz') + with urllib.request.urlopen(EVMUT_URL) as r, open(tgz, 'wb') as f: + shutil.copyfileobj(r, f) + # extract archive + tar = tarfile.open(tgz, "r:gz") + tar.extractall(path=folder) + tar.close() + os.remove(tgz) + pd.LOGGER.info(f'EVmutation folder set: {folder}') + else: + folder = None + msg = ('For full functionality, please consider downloading ' + f'EVmutation data from {EVMUT_URL} and then set up the ' + 'relative path in the configuration file.') + pd.LOGGER.warn(msg) + pd.SETTINGS['EVmutation_local_folder'] = folder + + # check if DSSP is installed + which = pd.utilities.which + if which('dssp') is None and which('mkdssp') is None: + msg = ('For full functionality, please consider installing DSSP, ' + 'for instance by typing in a Linux terminal: ' + "'sudo apt install dssp'") + pd.LOGGER.warn(msg) + else: + pd.LOGGER.info('DSSP is installed on the system.') + + pd.SETTINGS.save() + pd.LOGGER.info('Setup complete.') + + return + + +def getDefaultTrainingDataset(): + # import training dataset included with package + working_dir = pd.SETTINGS.get('rhapsody_local_folder') + tar = tarfile.open(PACKAGE_DATA, "r:gz") + tar.extractall(path=working_dir) + tar.close() + fname = os.path.join(working_dir, TRAINING_DATASET) + training_dataset = np.load(fname) + os.remove(fname) + return training_dataset + + +def getDefaultClassifiers(): + """Returns a dictionary with the paths to the three default classifiers + (``'full'``, ``'reduced'`` and ``'EVmut'``) + """ + working_dir = pd.SETTINGS.get('rhapsody_local_folder') + clsf_folder = os.path.join(working_dir, DEFAULT_CLSF_DIR) + + def_clsfs = {fs: os.path.join(clsf_folder, fs, 'trained_classifier.pkl') + for fs in DEFAULT_FEATSETS} + + if any([not os.path.isfile(c) for c in def_clsfs.values()]): + raise IOError('One or more default classifiers are missing. ' + 'Please rerun setup with initialSetup(refresh=True)') + else: + return def_clsfs + + +def importDefaultClassifier(version): + """Imports the specified classifier and its summary + + :arg version: either 'full', 'reduced' or 'EVmut' + :type version: str + """ + assert version in ['full', 'reduced', 'EVmut'] + with open(getDefaultClassifiers()[version], 'rb') as p: + clsf = pickle.load(p) + return clsf + + +def delSettings(): + for entry in ['rhapsody_local_folder', 'rhapsody_training_dataset', + 'EVmutation_local_folder', 'EVmutation_metrics']: + pd.SETTINGS.pop(entry) + + +def getSettings(print=True): + """Returns and prints essential information about the current Rhapsody + configuration, such as the location of working directory and default + classifiers + """ + + config_dict = {} + + for entry in ['rhapsody_local_folder', 'rhapsody_training_dataset', + 'EVmutation_local_folder', 'EVmutation_metrics']: + config_dict[entry] = pd.SETTINGS.get(entry) + + def_clsfs = getDefaultClassifiers() + for fs, path in def_clsfs.items(): + fs += ' classifier' + config_dict[fs] = path + + if print: + entries = ['rhapsody_local_folder', 'EVmutation_local_folder'] \ + + [f'{c} classifier' for c in def_clsfs] + for entry in entries: + pd.LOGGER.info(f'{entry:24}: {config_dict[entry]}') + d = pd.SETTINGS['rhapsody_training_dataset'] + pd.LOGGER.info('training dataset size : {}'.format(d['size'])) + if 'AUROC' in pd.SETTINGS.get('EVmutation_metrics', {}): + pd.LOGGER.info('EVmutation_metrics : ') + else: + pd.LOGGER.info('EVmutation_metrics : ') + + return config_dict From c43117be0b1336e2c394d8dd25478152320228a8 Mon Sep 17 00:00:00 2001 From: luponzo86 Date: Thu, 14 Nov 2019 12:55:56 -0800 Subject: [PATCH 14/24] - --- .travis.yml | 1 + setup.py | 6 ++++-- 2 files changed, 5 insertions(+), 2 deletions(-) diff --git a/.travis.yml b/.travis.yml index 9ca8eb9..85d6005 100644 --- a/.travis.yml +++ b/.travis.yml @@ -38,6 +38,7 @@ before_install: # install dependencies for rhapsody - conda install requests numpy scikit-learn - conda install matplotlib + - pip install tqdm install: # - python setup.py install diff --git a/setup.py b/setup.py index 82bd9fd..b208bbc 100644 --- a/setup.py +++ b/setup.py @@ -17,8 +17,10 @@ version=version, packages=find_packages(exclude=['contrib', 'docs', 'tests']), python_requires='>=3.5, <4', - install_requires=['requests', 'numpy', 'scikit-learn', 'matplotlib', - 'biopython', 'pyparsing', 'prody'], + install_requires=[ + 'requests', 'tqdm', + 'numpy', 'scikit-learn', 'matplotlib', + 'biopython', 'pyparsing', 'prody'], extras_require={ 'docs': ['sphinx >= 1.4', 'sphinx_theme', 'sphinx_rtd_theme'] }, From a584f7478d0eb8bbfb0a2bb1b36bb47042094923 Mon Sep 17 00:00:00 2001 From: luponzo86 Date: Sun, 8 Dec 2019 15:34:42 -0800 Subject: [PATCH 15/24] add '.importFeatMatrix()' and 'ignore_PolyPhen2_errors' option to core --- rhapsody/features/PolyPhen2.py | 5 ++++- rhapsody/predict/core.py | 16 +++++++++++++--- 2 files changed, 17 insertions(+), 4 deletions(-) diff --git a/rhapsody/features/PolyPhen2.py b/rhapsody/features/PolyPhen2.py index 709461c..b5ebf69 100644 --- a/rhapsody/features/PolyPhen2.py +++ b/rhapsody/features/PolyPhen2.py @@ -104,7 +104,8 @@ def _replace_strings_in_file(fname, new_fname, dict_substitutions): def queryPolyPhen2(filename, dump=True, prefix='pph2', - fasta_file=None, fix_isoforms=False, **kwargs): + fasta_file=None, fix_isoforms=False, + ignore_errors=False, **kwargs): # original PolyPhen-2 curl command (see: # http://genetics.bwh.harvard.edu/pph2/dokuwiki/faq ): # @@ -196,6 +197,8 @@ def queryPolyPhen2(filename, dump=True, prefix='pph2', if dump: outfile = f'pph2-{k}.txt' _replace_strings_in_file(outfile, outfile, orig_accs) + elif not ignore_errors: + LOGGER.warn('Please check PolyPhen-2 log file') else: LOGGER.error('Please check PolyPhen-2 log file') diff --git a/rhapsody/predict/core.py b/rhapsody/predict/core.py index b3f03bf..c05999b 100644 --- a/rhapsody/predict/core.py +++ b/rhapsody/predict/core.py @@ -60,7 +60,8 @@ def __init__(self, query=None, query_type='SAVs', queryPolyPhen2=True, 'status_file_Pfam', 'status_prefix_Uniprot', 'status_prefix_PDB', - 'status_prefix_Pfam'] + 'status_prefix_Pfam', + 'ignore_PolyPhen2_errors'] assert all([k in valid_kwargs for k in kwargs]) # masked NumPy array that will contain all info abut SAVs @@ -218,7 +219,8 @@ def queryPolyPhen2(self, query, filename='rhapsody-SAVs.txt'): # submit query to PolyPhen-2 try: PolyPhen2_output = PolyPhen2.queryPolyPhen2( - SAV_file, fix_isoforms=fix_isoforms) + SAV_file, fix_isoforms=fix_isoforms, + ignore_errors=self.options.get('ignore_PolyPhen2_errors')) except Exception as e: err = (f'Unable to get a response from PolyPhen-2: {e} \n' 'Please click "Check Status" on the server homepage \n' @@ -398,6 +400,14 @@ def _buildFeatMatrix(self, featset, all_features): feat_matrix[:, j] = array[featname] return feat_matrix + def importFeatMatrix(self, struct_array): + assert self.featMatrix is None, 'Feature matrix already set.' + assert self.featSet is not None, 'Feature set not set.' + assert self.data is not None, 'SAVs not set.' + assert len(struct_array) == self.numSAVs, 'Wrong length.' + featm = self._buildFeatMatrix(self.featSet, [struct_array]) + self.featMatrix = featm + def _calcFeatMatrix(self, refresh=False): assert self.data is not None, 'SAVs not set.' assert self.featSet is not None, 'Feature set not set.' @@ -460,7 +470,7 @@ def exportTrainingData(self, refresh=False): trainData[f] = self.featMatrix[:, i] return trainData - def importPrecomputedFeatures(self, features_dict): + def importPrecomputedExtraFeatures(self, features_dict): assert isinstance(features_dict, dict) # import additional precomputed features default_feats = RHAPSODY_FEATS['all'] From a6d9d3c7813c534571d3439f7bb690aaa4efd543 Mon Sep 17 00:00:00 2001 From: luponzo86 Date: Mon, 9 Dec 2019 17:07:13 -0800 Subject: [PATCH 16/24] add authorship to predict submodules --- rhapsody/predict/core.py | 6 ++++++ rhapsody/predict/figures.py | 6 ++++++ rhapsody/predict/main.py | 6 ++++++ 3 files changed, 18 insertions(+) diff --git a/rhapsody/predict/core.py b/rhapsody/predict/core.py index c05999b..cef6926 100644 --- a/rhapsody/predict/core.py +++ b/rhapsody/predict/core.py @@ -14,6 +14,12 @@ __all__ = ['Rhapsody', 'calcPredictions'] +__author__ = "Luca Ponzoni" +__date__ = "December 2019" +__maintainer__ = "Luca Ponzoni" +__email__ = "lponzoni@pitt.edu" +__status__ = "Production" + class Rhapsody: """A class implementing the Rhapsody algorithm for pathogenicity diff --git a/rhapsody/predict/figures.py b/rhapsody/predict/figures.py index fb33093..f742d93 100644 --- a/rhapsody/predict/figures.py +++ b/rhapsody/predict/figures.py @@ -11,6 +11,12 @@ __all__ = ['print_sat_mutagen_figure'] +__author__ = "Luca Ponzoni" +__date__ = "December 2019" +__maintainer__ = "Luca Ponzoni" +__email__ = "lponzoni@pitt.edu" +__status__ = "Production" + def _try_import_matplotlib(): try: diff --git a/rhapsody/predict/main.py b/rhapsody/predict/main.py index 22f93cd..780f0bd 100644 --- a/rhapsody/predict/main.py +++ b/rhapsody/predict/main.py @@ -8,6 +8,12 @@ __all__ = ['rhapsody'] +__author__ = "Luca Ponzoni" +__date__ = "December 2019" +__maintainer__ = "Luca Ponzoni" +__email__ = "lponzoni@pitt.edu" +__status__ = "Production" + def rhapsody(query, query_type='SAVs', main_classifier=None, aux_classifier=None, From d9e63181c916bb98e1a578725799341a53534a5f Mon Sep 17 00:00:00 2001 From: luponzo86 Date: Mon, 9 Dec 2019 17:37:54 -0800 Subject: [PATCH 17/24] add authorship to all modules --- rhapsody/__init__.py | 6 ++++++ rhapsody/features/BLOSUM.py | 6 ++++++ rhapsody/features/EVmutation.py | 17 +++++++++++------ rhapsody/features/PDB.py | 5 +++++ rhapsody/features/Pfam.py | 6 ++++++ rhapsody/features/PolyPhen2.py | 6 ++++++ rhapsody/features/Uniprot.py | 6 ++++++ rhapsody/features/__init__.py | 6 ++++++ rhapsody/predict/__init__.py | 6 ++++++ rhapsody/train/RFtraining.py | 5 +++++ rhapsody/train/__init__.py | 6 ++++++ rhapsody/train/figures.py | 6 ++++++ rhapsody/utils/__init__.py | 6 ++++++ rhapsody/utils/misc.py | 6 ++++++ rhapsody/utils/settings.py | 6 ++++++ setup.py | 6 ++++++ test/test-1/test-1.py | 7 +++++++ test/test-2/test-2.py | 7 +++++++ 18 files changed, 113 insertions(+), 6 deletions(-) diff --git a/rhapsody/__init__.py b/rhapsody/__init__.py index eb5d235..c07620c 100644 --- a/rhapsody/__init__.py +++ b/rhapsody/__init__.py @@ -11,6 +11,12 @@ __release__ = __version__ +__author__ = "Luca Ponzoni" +__date__ = "December 2019" +__maintainer__ = "Luca Ponzoni" +__email__ = "lponzoni@pitt.edu" +__status__ = "Production" + __all__ = [] from . import utils diff --git a/rhapsody/features/BLOSUM.py b/rhapsody/features/BLOSUM.py index f432624..c3e4508 100644 --- a/rhapsody/features/BLOSUM.py +++ b/rhapsody/features/BLOSUM.py @@ -5,6 +5,12 @@ import numpy as np from Bio.SubsMat.MatrixInfo import blosum62 +__author__ = "Luca Ponzoni" +__date__ = "December 2019" +__maintainer__ = "Luca Ponzoni" +__email__ = "lponzoni@pitt.edu" +__status__ = "Production" + __all__ = ['BLOSUM_FEATS', 'calcBLOSUMfeatures'] BLOSUM_FEATS = ['BLOSUM'] diff --git a/rhapsody/features/EVmutation.py b/rhapsody/features/EVmutation.py index 1a3f90f..8f52180 100644 --- a/rhapsody/features/EVmutation.py +++ b/rhapsody/features/EVmutation.py @@ -7,12 +7,11 @@ from os.path import splitext, join, basename from prody import SETTINGS, LOGGER -# extract precomputed EVmutation scores for given mutants -# NB: -# negative DeltaE_epist --> deleterious effect -# DeltaE_epist == 0 --> neutral effect (wild-type) -# positive DeltaE_epist --> neutral/benign effect - +__author__ = "Luca Ponzoni" +__date__ = "December 2019" +__maintainer__ = "Luca Ponzoni" +__email__ = "lponzoni@pitt.edu" +__status__ = "Production" __all__ = ['EVMUT_FEATS', 'recoverEVmutFeatures'] @@ -35,6 +34,12 @@ def recoverEVmutFeatures(SAVs): LOGGER.timeit('_EVmut') LOGGER.info('Recovering EVmutation data...') + # extracts precomputed EVmutation scores for given mutants + # NB: + # negative DeltaE_epist --> deleterious effect + # DeltaE_epist == 0 --> neutral effect (wild-type) + # positive DeltaE_epist --> neutral/benign effect + def find_matching_files(file_list, acc, pos): match_files = [] for fname in [f for f in file_list if f.startswith(acc)]: diff --git a/rhapsody/features/PDB.py b/rhapsody/features/PDB.py index 4d8b27e..555a1a7 100644 --- a/rhapsody/features/PDB.py +++ b/rhapsody/features/PDB.py @@ -15,6 +15,11 @@ from prody import reduceModel, sliceModel from prody import execDSSP, parseDSSP +__author__ = "Luca Ponzoni" +__date__ = "December 2019" +__maintainer__ = "Luca Ponzoni" +__email__ = "lponzoni@pitt.edu" +__status__ = "Production" __all__ = ['STR_FEATS', 'DYN_FEATS', 'PDB_FEATS', 'PDBfeatures', 'calcPDBfeatures'] diff --git a/rhapsody/features/Pfam.py b/rhapsody/features/Pfam.py index 57117e5..27548f3 100644 --- a/rhapsody/features/Pfam.py +++ b/rhapsody/features/Pfam.py @@ -9,6 +9,12 @@ from prody import LOGGER from .Uniprot import UniprotMapping +__author__ = "Luca Ponzoni" +__date__ = "December 2019" +__maintainer__ = "Luca Ponzoni" +__email__ = "lponzoni@pitt.edu" +__status__ = "Production" + __all__ = ['PFAM_FEATS', 'calcPfamFeatures'] PFAM_FEATS = ['entropy', 'ranked_MI'] diff --git a/rhapsody/features/PolyPhen2.py b/rhapsody/features/PolyPhen2.py index b5ebf69..b9ce7b2 100644 --- a/rhapsody/features/PolyPhen2.py +++ b/rhapsody/features/PolyPhen2.py @@ -13,6 +13,12 @@ from requests.packages.urllib3.util.retry import Retry from math import log +__author__ = "Luca Ponzoni" +__date__ = "December 2019" +__maintainer__ = "Luca Ponzoni" +__email__ = "lponzoni@pitt.edu" +__status__ = "Production" + __all__ = ['PP2_FEATS', 'queryPolyPhen2', 'parsePolyPhen2output', 'getSAVcoords', 'calcPolyPhen2features'] diff --git a/rhapsody/features/Uniprot.py b/rhapsody/features/Uniprot.py index 83b8dc0..4c016cb 100644 --- a/rhapsody/features/Uniprot.py +++ b/rhapsody/features/Uniprot.py @@ -14,6 +14,12 @@ from Bio.pairwise2 import format_alignment from Bio.SubsMat import MatrixInfo as matlist +__author__ = "Luca Ponzoni" +__date__ = "December 2019" +__maintainer__ = "Luca Ponzoni" +__email__ = "lponzoni@pitt.edu" +__status__ = "Production" + __all__ = ['UniprotMapping', 'mapSAVs2PDB', 'seqScanning', 'printSAVlist'] diff --git a/rhapsody/features/__init__.py b/rhapsody/features/__init__.py index af6cb8e..254bbbc 100644 --- a/rhapsody/features/__init__.py +++ b/rhapsody/features/__init__.py @@ -4,6 +4,12 @@ EVmutation precomputed data. """ +__author__ = "Luca Ponzoni" +__date__ = "December 2019" +__maintainer__ = "Luca Ponzoni" +__email__ = "lponzoni@pitt.edu" +__status__ = "Production" + __all__ = ['RHAPSODY_FEATS'] from . import Uniprot diff --git a/rhapsody/predict/__init__.py b/rhapsody/predict/__init__.py index a78b60e..c63e270 100644 --- a/rhapsody/predict/__init__.py +++ b/rhapsody/predict/__init__.py @@ -5,6 +5,12 @@ __all__ = [] +__author__ = "Luca Ponzoni" +__date__ = "December 2019" +__maintainer__ = "Luca Ponzoni" +__email__ = "lponzoni@pitt.edu" +__status__ = "Production" + from . import core from .core import * __all__.extend(core.__all__) diff --git a/rhapsody/train/RFtraining.py b/rhapsody/train/RFtraining.py index 4fde02d..42149dc 100644 --- a/rhapsody/train/RFtraining.py +++ b/rhapsody/train/RFtraining.py @@ -16,6 +16,11 @@ from .figures import print_pred_distrib_figure, print_path_prob_figure from .figures import print_ROC_figure, print_feat_imp_figure +__author__ = "Luca Ponzoni" +__date__ = "December 2019" +__maintainer__ = "Luca Ponzoni" +__email__ = "lponzoni@pitt.edu" +__status__ = "Production" __all__ = ['calcScoreMetrics', 'calcClassMetrics', 'calcPathogenicityProbs', 'RandomForestCV', 'trainRFclassifier', diff --git a/rhapsody/train/__init__.py b/rhapsody/train/__init__.py index fa8a85a..d7049c2 100644 --- a/rhapsody/train/__init__.py +++ b/rhapsody/train/__init__.py @@ -3,6 +3,12 @@ assess their accuracy. """ +__author__ = "Luca Ponzoni" +__date__ = "December 2019" +__maintainer__ = "Luca Ponzoni" +__email__ = "lponzoni@pitt.edu" +__status__ = "Production" + __all__ = [] from . import RFtraining diff --git a/rhapsody/train/figures.py b/rhapsody/train/figures.py index 4ea3ecc..988289f 100644 --- a/rhapsody/train/figures.py +++ b/rhapsody/train/figures.py @@ -6,6 +6,12 @@ import numpy as np from prody import LOGGER +__author__ = "Luca Ponzoni" +__date__ = "December 2019" +__maintainer__ = "Luca Ponzoni" +__email__ = "lponzoni@pitt.edu" +__status__ = "Production" + __all__ = ['print_pred_distrib_figure', 'print_path_prob_figure', 'print_ROC_figure', 'print_feat_imp_figure'] diff --git a/rhapsody/utils/__init__.py b/rhapsody/utils/__init__.py index e84fa6b..1554e0a 100644 --- a/rhapsody/utils/__init__.py +++ b/rhapsody/utils/__init__.py @@ -3,6 +3,12 @@ and for accessing installation settings and other parameters. """ +__author__ = "Luca Ponzoni" +__date__ = "December 2019" +__maintainer__ = "Luca Ponzoni" +__email__ = "lponzoni@pitt.edu" +__status__ = "Production" + __all__ = [] from . import settings diff --git a/rhapsody/utils/misc.py b/rhapsody/utils/misc.py index 3df3632..4c5f6f3 100644 --- a/rhapsody/utils/misc.py +++ b/rhapsody/utils/misc.py @@ -12,6 +12,12 @@ import prody as pd import rhapsody as rd +__author__ = "Luca Ponzoni" +__date__ = "December 2019" +__maintainer__ = "Luca Ponzoni" +__email__ = "lponzoni@pitt.edu" +__status__ = "Production" + __all__ = ['DEFAULT_FEATSETS', 'initialSetup', 'getDefaultTrainingDataset', 'getDefaultClassifiers', 'importDefaultClassifier', 'delSettings', 'getSettings'] diff --git a/rhapsody/utils/settings.py b/rhapsody/utils/settings.py index 3df3632..4c5f6f3 100644 --- a/rhapsody/utils/settings.py +++ b/rhapsody/utils/settings.py @@ -12,6 +12,12 @@ import prody as pd import rhapsody as rd +__author__ = "Luca Ponzoni" +__date__ = "December 2019" +__maintainer__ = "Luca Ponzoni" +__email__ = "lponzoni@pitt.edu" +__status__ = "Production" + __all__ = ['DEFAULT_FEATSETS', 'initialSetup', 'getDefaultTrainingDataset', 'getDefaultClassifiers', 'importDefaultClassifier', 'delSettings', 'getSettings'] diff --git a/setup.py b/setup.py index b208bbc..218bcf9 100644 --- a/setup.py +++ b/setup.py @@ -6,6 +6,12 @@ from os import path from io import open +__author__ = "Luca Ponzoni" +__date__ = "December 2019" +__maintainer__ = "Luca Ponzoni" +__email__ = "lponzoni@pitt.edu" +__status__ = "Production" + here = path.abspath(path.dirname(__file__)) with open(path.join(here, 'VERSION'), encoding='utf-8') as f: version = f.read() diff --git a/test/test-1/test-1.py b/test/test-1/test-1.py index f36b86a..b46c5e4 100644 --- a/test/test-1/test-1.py +++ b/test/test-1/test-1.py @@ -8,6 +8,13 @@ sys.path.append('../../') import rhapsody as rd +__author__ = "Luca Ponzoni" +__date__ = "December 2019" +__maintainer__ = "Luca Ponzoni" +__email__ = "lponzoni@pitt.edu" +__status__ = "Production" + + # temporarily switch to new set of folders if not os.path.isdir('workspace'): os.mkdir('workspace') diff --git a/test/test-2/test-2.py b/test/test-2/test-2.py index 5f2c785..c0d11d7 100644 --- a/test/test-2/test-2.py +++ b/test/test-2/test-2.py @@ -7,6 +7,13 @@ sys.path.append('../../') import rhapsody as rd +__author__ = "Luca Ponzoni" +__date__ = "December 2019" +__maintainer__ = "Luca Ponzoni" +__email__ = "lponzoni@pitt.edu" +__status__ = "Production" + + # temporarily switch to new set of folders if not os.path.isdir('workspace'): os.mkdir('workspace') From 5b69deeb0f6c75cc3769b2befa913e443bfd2204 Mon Sep 17 00:00:00 2001 From: luponzo86 Date: Mon, 9 Dec 2019 17:47:24 -0800 Subject: [PATCH 18/24] VERSION file moved inside rhapsody module --- docs/rhapsody.utils.rst | 8 ++++++++ VERSION => rhapsody/VERSION | 0 rhapsody/__init__.py | 2 +- setup.py | 2 +- 4 files changed, 10 insertions(+), 2 deletions(-) rename VERSION => rhapsody/VERSION (100%) diff --git a/docs/rhapsody.utils.rst b/docs/rhapsody.utils.rst index 73536ab..4b17180 100644 --- a/docs/rhapsody.utils.rst +++ b/docs/rhapsody.utils.rst @@ -9,6 +9,14 @@ rhapsody.utils package Submodules ---------- +rhapsody.utils.misc module +-------------------------- + +.. automodule:: rhapsody.utils.misc + :members: + :undoc-members: + :show-inheritance: + rhapsody.utils.settings module ------------------------------ diff --git a/VERSION b/rhapsody/VERSION similarity index 100% rename from VERSION rename to rhapsody/VERSION diff --git a/rhapsody/__init__.py b/rhapsody/__init__.py index c07620c..b07e565 100644 --- a/rhapsody/__init__.py +++ b/rhapsody/__init__.py @@ -6,7 +6,7 @@ from os import path here = path.abspath(path.dirname(__file__)) -with open(path.join(here, '../VERSION'), encoding='utf-8') as f: +with open(path.join(here, 'VERSION'), encoding='utf-8') as f: __version__ = f.read() __release__ = __version__ diff --git a/setup.py b/setup.py index 218bcf9..26e5944 100644 --- a/setup.py +++ b/setup.py @@ -13,7 +13,7 @@ __status__ = "Production" here = path.abspath(path.dirname(__file__)) -with open(path.join(here, 'VERSION'), encoding='utf-8') as f: +with open(path.join(here, 'rhapsody/VERSION'), encoding='utf-8') as f: version = f.read() with open(path.join(here, 'README.md'), encoding='utf-8') as f: long_description = f.read() From ca48d4a8b0f8d5510996cd54562dabb8c3e96b5a Mon Sep 17 00:00:00 2001 From: luponzo86 Date: Mon, 9 Dec 2019 18:34:13 -0800 Subject: [PATCH 19/24] bug fix in PolyPhen2 output: path. class = 'none' is sometimes used instead of '?' --- rhapsody/predict/core.py | 3 ++- 1 file changed, 2 insertions(+), 1 deletion(-) diff --git a/rhapsody/predict/core.py b/rhapsody/predict/core.py index cef6926..16ac297 100644 --- a/rhapsody/predict/core.py +++ b/rhapsody/predict/core.py @@ -594,7 +594,8 @@ def _calcPolyPhen2Predictions(self): return PP2_score = [x if x != '?' else 'nan' for x in self.PolyPhen2output['pph2_prob']] - PP2_class = self.PolyPhen2output['pph2_class'] + PP2_class = [x if x not in ['none', '?'] else '?' for x in + self.PolyPhen2output['pph2_class'] self.data['PolyPhen-2 score'] = PP2_score self.data['PolyPhen-2 path. class'] = PP2_class From 9ca2727bd904285af3fef1be34058df55fab9ad9 Mon Sep 17 00:00:00 2001 From: luponzo86 Date: Mon, 9 Dec 2019 18:35:18 -0800 Subject: [PATCH 20/24] bug fix in _isSaturationMutagenesis() --- rhapsody/predict/core.py | 2 +- 1 file changed, 1 insertion(+), 1 deletion(-) diff --git a/rhapsody/predict/core.py b/rhapsody/predict/core.py index 16ac297..2fae2a6 100644 --- a/rhapsody/predict/core.py +++ b/rhapsody/predict/core.py @@ -151,7 +151,7 @@ def _isSaturationMutagenesis(self): self.saturation_mutagenesis = False try: SAVs = self.getUniqueSAVcoords() - SAV_list = list(SAVs['SAV coords']) + SAV_list = list(SAVs['unique SAV coords']) acc = SAVs[0]['Uniprot ID'] pos = list(set(SAVs['position'])) if len(pos) == 1: From b8946639dc5bbaa6d2540119ff7da7e057d04102 Mon Sep 17 00:00:00 2001 From: luponzo86 Date: Tue, 10 Dec 2019 09:41:51 -0800 Subject: [PATCH 21/24] - --- rhapsody/predict/core.py | 2 +- 1 file changed, 1 insertion(+), 1 deletion(-) diff --git a/rhapsody/predict/core.py b/rhapsody/predict/core.py index 2fae2a6..87a2005 100644 --- a/rhapsody/predict/core.py +++ b/rhapsody/predict/core.py @@ -595,7 +595,7 @@ def _calcPolyPhen2Predictions(self): PP2_score = [x if x != '?' else 'nan' for x in self.PolyPhen2output['pph2_prob']] PP2_class = [x if x not in ['none', '?'] else '?' for x in - self.PolyPhen2output['pph2_class'] + self.PolyPhen2output['pph2_class']] self.data['PolyPhen-2 score'] = PP2_score self.data['PolyPhen-2 path. class'] = PP2_class From 23a87053b97e37fc2cba2a4c4eba615ad2816dd9 Mon Sep 17 00:00:00 2001 From: luponzo86 Date: Fri, 13 Dec 2019 10:55:00 -0800 Subject: [PATCH 22/24] version 0.9.5 --- rhapsody/VERSION | 2 +- setup.py | 4 +--- 2 files changed, 2 insertions(+), 4 deletions(-) diff --git a/rhapsody/VERSION b/rhapsody/VERSION index 2bd77c7..b0bb878 100644 --- a/rhapsody/VERSION +++ b/rhapsody/VERSION @@ -1 +1 @@ -0.9.4 \ No newline at end of file +0.9.5 diff --git a/setup.py b/setup.py index 26e5944..6079ec2 100644 --- a/setup.py +++ b/setup.py @@ -36,7 +36,7 @@ long_description_content_type='text/markdown', url='https://github.com/prody/rhapsody', author='Luca Ponzoni', - author_email='ponzoniluca@gmail.com', + author_email='lponzoni@pitt.edu', platforms=['Windows', 'MacOS X', 'POSIX'], license='GPL', classifiers=[ @@ -51,8 +51,6 @@ 'Operating System :: POSIX', 'License :: OSI Approved :: GNU General Public License v3 (GPLv3)', - 'Programming Language :: Python :: 3', - 'Programming Language :: Python :: 3.5', 'Programming Language :: Python :: 3.6', 'Programming Language :: Python :: 3.7', ], From 557d4e42e94b07f1e367fc8980a28ab70db50f90 Mon Sep 17 00:00:00 2001 From: luponzo86 Date: Fri, 13 Dec 2019 12:16:21 -0800 Subject: [PATCH 23/24] bug fix, version 0.9.6 --- MANIFEST.in | 2 ++ rhapsody/VERSION | 2 +- setup.py | 2 +- 3 files changed, 4 insertions(+), 2 deletions(-) create mode 100644 MANIFEST.in diff --git a/MANIFEST.in b/MANIFEST.in new file mode 100644 index 0000000..75da6b2 --- /dev/null +++ b/MANIFEST.in @@ -0,0 +1,2 @@ +include rhapsody/VERSION +include rhapsody/data.tar.gz \ No newline at end of file diff --git a/rhapsody/VERSION b/rhapsody/VERSION index b0bb878..85b7c69 100644 --- a/rhapsody/VERSION +++ b/rhapsody/VERSION @@ -1 +1 @@ -0.9.5 +0.9.6 diff --git a/setup.py b/setup.py index 6079ec2..32a878c 100644 --- a/setup.py +++ b/setup.py @@ -22,7 +22,7 @@ name='prody-rhapsody', version=version, packages=find_packages(exclude=['contrib', 'docs', 'tests']), - python_requires='>=3.5, <4', + python_requires='>=3.6, <4', install_requires=[ 'requests', 'tqdm', 'numpy', 'scikit-learn', 'matplotlib', From 95cb130c499a15a14a00a332d7db92e4243331ae Mon Sep 17 00:00:00 2001 From: luponzo86 Date: Fri, 13 Dec 2019 12:53:29 -0800 Subject: [PATCH 24/24] - --- rhapsody/VERSION | 2 +- setup.py | 1 + 2 files changed, 2 insertions(+), 1 deletion(-) diff --git a/rhapsody/VERSION b/rhapsody/VERSION index 85b7c69..c81aa44 100644 --- a/rhapsody/VERSION +++ b/rhapsody/VERSION @@ -1 +1 @@ -0.9.6 +0.9.7 diff --git a/setup.py b/setup.py index 32a878c..1ee65c6 100644 --- a/setup.py +++ b/setup.py @@ -30,6 +30,7 @@ extras_require={ 'docs': ['sphinx >= 1.4', 'sphinx_theme', 'sphinx_rtd_theme'] }, + include_package_data=True, description="""Python program, based on ProDy, for pathogenicity prediction of human missense variants.""", long_description=long_description,