diff --git a/doc/source/reference/frame.rst b/doc/source/reference/frame.rst
index 31a1c6008bce8..7680c8b434866 100644
--- a/doc/source/reference/frame.rst
+++ b/doc/source/reference/frame.rst
@@ -74,6 +74,7 @@ Indexing, iteration
    DataFrame.where
    DataFrame.mask
    DataFrame.query
+   DataFrame.isetitem
 
 For more information on ``.at``, ``.iat``, ``.loc``, and
 ``.iloc``,  see the :ref:`indexing documentation <indexing>`.
diff --git a/pandas/core/frame.py b/pandas/core/frame.py
index e5d424b15e69e..f530466c0fc30 100644
--- a/pandas/core/frame.py
+++ b/pandas/core/frame.py
@@ -4018,6 +4018,11 @@ def isetitem(self, loc, value) -> None:
         value : scalar or arraylike
             Value(s) for the column.
 
+        See Also
+        --------
+        DataFrame.iloc : Purely integer-location based indexing for selection by
+            position.
+
         Notes
         -----
         ``frame.isetitem(loc, value)`` is an in-place method as it will
@@ -4028,6 +4033,15 @@ def isetitem(self, loc, value) -> None:
 
         In cases where ``frame.columns`` is unique, this is equivalent to
         ``frame[frame.columns[i]] = value``.
+
+        Examples
+        --------
+        >>> df = pd.DataFrame({"A": [1, 2], "B": [3, 4]})
+        >>> df.isetitem(1, [5, 6])
+        >>> df
+              A  B
+        0     1  5
+        1     2  6
         """
         if isinstance(value, DataFrame):
             if is_integer(loc):