diff --git a/pex/fetcher.py b/pex/fetcher.py
index 6e94da241..15e98cb8b 100644
--- a/pex/fetcher.py
+++ b/pex/fetcher.py
@@ -7,9 +7,17 @@
 import time
 from contextlib import closing, contextmanager
 
-from pex.compatibility import FileHandler, HTTPError, HTTPSHandler, ProxyHandler, build_opener
+from pex.compatibility import (
+    FileHandler,
+    HTTPError,
+    HTTPSHandler,
+    ProxyHandler,
+    Request,
+    build_opener,
+)
 from pex.network_configuration import NetworkConfiguration
 from pex.typing import TYPE_CHECKING, cast
+from pex.version import __version__
 
 if TYPE_CHECKING:
     from typing import BinaryIO, Dict, Iterator, Optional, Text
@@ -18,6 +26,8 @@
 
 
 class URLFetcher(object):
+    USER_AGENT = "pex/{version}".format(version=__version__)
+
     def __init__(
         self,
         network_configuration=None,  # type: Optional[NetworkConfiguration]
@@ -54,10 +64,16 @@ def get_body_stream(self, url):
                 retry_delay_secs *= 2
 
             opener = build_opener(*self._handlers)
+            request = Request(
+                # N.B.: MyPy incorrectly thinks url must be a str in Python 2 where a unicode url
+                # actually works fine.
+                url,  # type: ignore[arg-type]
+                headers={"User-Agent": self.USER_AGENT},
+            )
             # The fp is typed as Optional[...] for Python 2 only in the typeshed. A `None`
             # can only be returned if a faulty custom handler is installed and we only
             # install stdlib handlers.
-            fp = cast(BinaryIO, opener.open(url, timeout=self._timeout))
+            fp = cast(BinaryIO, opener.open(request, timeout=self._timeout))
             try:
                 with closing(fp) as body_stream:
                     yield body_stream
diff --git a/tests/test_fetcher.py b/tests/test_fetcher.py
new file mode 100644
index 000000000..f73fefc1f
--- /dev/null
+++ b/tests/test_fetcher.py
@@ -0,0 +1,57 @@
+# Copyright 2022 Pants project contributors (see CONTRIBUTORS.md).
+# Licensed under the Apache License, Version 2.0 (see LICENSE).
+
+from __future__ import print_function
+
+from threading import Thread
+
+import pytest
+
+from pex.compatibility import PY2
+from pex.fetcher import URLFetcher
+from pex.typing import TYPE_CHECKING
+from pex.version import __version__
+
+if PY2:
+    from BaseHTTPServer import BaseHTTPRequestHandler
+    from SocketServer import TCPServer
+else:
+    from http.server import BaseHTTPRequestHandler
+    from socketserver import TCPServer
+
+if TYPE_CHECKING:
+    from typing import Tuple
+
+
+@pytest.fixture
+def server_address():
+    class GETRequestHandler(BaseHTTPRequestHandler):
+        def do_GET(self):
+            body = self.headers["User-Agent"].encode("utf-8")
+            self.send_response(200)
+            self.send_header("Content-Type", "application/octet-stream")
+            self.send_header("Content-Length", str(len(body)))
+            self.end_headers()
+            self.wfile.write(body)
+
+    server = TCPServer(("127.0.0.1", 0), GETRequestHandler)
+    host, port = server.server_address
+
+    server_thread = Thread(target=server.serve_forever)
+    server_thread.daemon = True
+    server_thread.start()
+    try:
+        yield host, port
+    finally:
+        server.shutdown()
+        server_thread.join()
+
+
+def test_user_agent(server_address):
+    # type: (Tuple[str, int]) -> None
+
+    host, port = server_address
+    url = "http://{host}:{port}".format(host=host, port=port)
+    url_fetcher = URLFetcher()
+    with url_fetcher.get_body_stream(url) as fp:
+        assert "pex/{version}".format(version=__version__) == fp.read().decode("utf-8")