diff --git a/pex/version.py b/pex/version.py
index e0acc849f..3b7ea4a16 100644
--- a/pex/version.py
+++ b/pex/version.py
@@ -3,5 +3,5 @@
 
 __version__ = '1.1.15'
 
-SETUPTOOLS_REQUIREMENT = 'setuptools>=5.7,<20.11'
+SETUPTOOLS_REQUIREMENT = 'setuptools>=5.7,<31.0'
 WHEEL_REQUIREMENT = 'wheel>=0.26.0,<0.30.0'
diff --git a/scripts/coverage.sh b/scripts/coverage.sh
index a7317a8c6..25ed07a73 100755
--- a/scripts/coverage.sh
+++ b/scripts/coverage.sh
@@ -4,4 +4,4 @@ coverage run -p -m py.test tests
 coverage run -p -m pex.bin.pex -v --help >&/dev/null
 coverage run -p -m pex.bin.pex -v -- scripts/do_nothing.py
 coverage run -p -m pex.bin.pex -v requests -- scripts/do_nothing.py
-coverage run -p -m pex.bin.pex -v . 'setuptools>=5.7,<20.11' -- scripts/do_nothing.py
+coverage run -p -m pex.bin.pex -v . 'setuptools>=5.7,<31.0' -- scripts/do_nothing.py