diff --git a/cmd/zfs_object_agent/util/src/zettacache_stats.rs b/cmd/zfs_object_agent/util/src/zettacache_stats.rs
index 63a6e47cd913..e1e47c54b77a 100644
--- a/cmd/zfs_object_agent/util/src/zettacache_stats.rs
+++ b/cmd/zfs_object_agent/util/src/zettacache_stats.rs
@@ -104,7 +104,9 @@ impl Sub<Self> for &StatCount {
     type Output = StatCount;
 
     fn sub(self, other: Self) -> Self::Output {
-        StatCount(AtomicU64::new(self.0.load(Relaxed) - other.0.load(Relaxed)))
+        StatCount(AtomicU64::new(
+            self.0.load(Relaxed).saturating_sub(other.0.load(Relaxed)),
+        ))
     }
 }
 
@@ -144,7 +146,9 @@ impl Sub<Self> for &StatBytes {
     type Output = StatBytes;
 
     fn sub(self, other: Self) -> Self::Output {
-        StatBytes(AtomicU64::new(self.0.load(Relaxed) - other.0.load(Relaxed)))
+        StatBytes(AtomicU64::new(
+            self.0.load(Relaxed).saturating_sub(other.0.load(Relaxed)),
+        ))
     }
 }
 
@@ -265,6 +269,7 @@ impl Sub<Self> for &IoStatValues {
 #[derive(Clone, Debug, Serialize, Deserialize)]
 pub struct DiskIoStats {
     pub name: String,
+    pub instance: u64, // unique instance for this disk
     pub stats: EnumMap<DiskIoType, IoStatValues>,
 }
 
@@ -272,6 +277,7 @@ impl DiskIoStats {
     pub fn new(name: String) -> DiskIoStats {
         DiskIoStats {
             name,
+            instance: rand::random(),
             stats: Default::default(),
         }
     }
@@ -320,38 +326,41 @@ pub struct IoStatsRef<'a> {
     pub disk_stats: Vec<&'a DiskIoStats>,
 }
 
-impl Sub<Self> for &IoStats {
-    type Output = IoStats;
+impl IoStats {
+    pub fn max_name_len(&self) -> usize {
+        self.disk_stats
+            .iter()
+            .map(|stats| stats.name.len())
+            .max()
+            .unwrap_or_default()
+    }
 
-    /// Subtract two IoStats. Used to create the net values between two IoStats samples.
-    fn sub(self, other: Self) -> IoStats {
+    /// Subtract two IoStats to create the net values between two samples.
+    /// Returns None if the two stats cannot be compared (agent restarted or a disk changed).
+    pub fn checked_sub(&self, other: &IoStats) -> Option<Self> {
         if other.disk_stats.is_empty() {
-            return self.clone();
+            return Some(self.clone());
+        }
+        // Avoid comparing stats when the agent was restarted or disks were changed
+        if self.cache_runtime_id != other.cache_runtime_id
+            || self.disk_stats.len() != other.disk_stats.len()
+        {
+            return None;
         }
-        assert_eq!(self.cache_runtime_id, other.cache_runtime_id);
-
         let mut difference = IoStats {
             timestamp: self.timestamp - other.timestamp,
             ..Default::default()
         };
-
-        assert_eq!(self.disk_stats.len(), other.disk_stats.len());
         for (self_stat, other_stat) in self.disk_stats.iter().zip(other.disk_stats.iter()) {
-            assert_eq!(self_stat.name, other_stat.name);
+            // Avoid comparing stats when disks have changed
+            if self_stat.instance != other_stat.instance {
+                return None;
+            }
+            // We're now confident that stats are comparable so the underlying stat subtraction
+            // (i.e. StatCount or StatBytes) is a saturating_sub()
             difference.disk_stats.push(self_stat - other_stat);
         }
-
-        difference
-    }
-}
-
-impl IoStats {
-    pub fn max_name_len(&self) -> usize {
-        self.disk_stats
-            .iter()
-            .map(|stats| stats.name.len())
-            .max()
-            .unwrap_or_default()
+        Some(difference)
     }
 }
 
diff --git a/cmd/zfs_object_agent/zcache/src/iostat.rs b/cmd/zfs_object_agent/zcache/src/iostat.rs
index f928d73b3761..be3e5f66272c 100644
--- a/cmd/zfs_object_agent/zcache/src/iostat.rs
+++ b/cmd/zfs_object_agent/zcache/src/iostat.rs
@@ -1,6 +1,9 @@
 //! The iostat subcommand for zcache.
 
 use std::cmp::max;
+use std::collections::hash_map::DefaultHasher;
+use std::hash::Hash;
+use std::hash::Hasher;
 use std::sync::atomic::Ordering::Relaxed;
 use std::thread::sleep;
 use std::time::Duration;
@@ -335,11 +338,7 @@ impl IoStatDisplay {
 
             debug!("{latest:?}");
 
-            if previous.disk_stats.is_empty()
-                || latest.cache_runtime_id == previous.cache_runtime_id
-            {
-                let delta = &latest - &previous;
-
+            if let Some(delta) = latest.checked_sub(&previous) {
                 match &self.histogram_name {
                     None => self.display_iostat_default(iteration, &delta),
                     Some(name) => self.display_iostat_histogram(name, &delta),
@@ -347,7 +346,7 @@ impl IoStatDisplay {
                 // Flush stdout in case output is redirected to a file
                 flush_stdout()?;
             } else {
-                info!("object agent restarted");
+                info!("object agent restarted or disks changed");
             }
 
             iteration += 1;
@@ -371,11 +370,19 @@ impl IoStatDisplay {
     }
 
     fn insert_summary_disk(disk_stats: &mut IoStats) {
-        let mut summary = DiskIoStats::new("summary".to_string());
+        let mut summary = DiskIoStats {
+            name: "summary".to_string(),
+            instance: 0,
+            stats: Default::default(),
+        };
+        let mut hasher = DefaultHasher::new();
 
         for disk in &disk_stats.disk_stats {
             summary += disk;
+            disk.instance.hash(&mut hasher);
         }
+        // Since the summay disk is compared first, make its instance depend on every disk
+        summary.instance = hasher.finish();
         disk_stats.disk_stats.insert(0, summary);
     }
 }