diff --git a/changelog/unreleased/bugfix-do-not-load-from-cache b/changelog/unreleased/bugfix-do-not-load-from-cache
new file mode 100644
index 00000000000..06f1d4c4ab3
--- /dev/null
+++ b/changelog/unreleased/bugfix-do-not-load-from-cache
@@ -0,0 +1,6 @@
+Bugfix: Do not load files from cache
+
+When apps (i.e Drawio) try to load a file, the browser caches the request.
+If the file was modified somewhere else, this causes inconsistent results which prevent saving any changes until the cache is properly cleared.
+
+https://github.com/owncloud/web/pull/6447
diff --git a/packages/web-app-draw-io/src/App.vue b/packages/web-app-draw-io/src/App.vue
index 968c9cb2dc4..06761821bbb 100644
--- a/packages/web-app-draw-io/src/App.vue
+++ b/packages/web-app-draw-io/src/App.vue
@@ -137,7 +137,7 @@ export default {
         })
     },
     load() {
-      this.getFileContents(this.filePath, { resolveWithResponseObject: true })
+      this.getFileContents(this.filePath)
         .then((resp) => {
           this.currentETag = resp.headers.ETag
           this.$refs.drawIoEditor.contentWindow.postMessage(
diff --git a/packages/web-pkg/src/composables/appDefaults/useAppFileHandling.ts b/packages/web-pkg/src/composables/appDefaults/useAppFileHandling.ts
index f78439256d0..7445079e979 100644
--- a/packages/web-pkg/src/composables/appDefaults/useAppFileHandling.ts
+++ b/packages/web-pkg/src/composables/appDefaults/useAppFileHandling.ts
@@ -69,7 +69,8 @@ export function useAppFileHandling(options: AppFileHandlingOptions): AppFileHand
       }
     } else {
       return client.files.getFileContents(filePath, {
-        resolveWithResponseObject: true
+        resolveWithResponseObject: true,
+        noCache: true
       })
     }
   }