diff --git a/substratevm/src/com.oracle.svm.core/src/com/oracle/svm/core/JavaMainWrapper.java b/substratevm/src/com.oracle.svm.core/src/com/oracle/svm/core/JavaMainWrapper.java
index e6fb30ca62ca..046421a9670d 100644
--- a/substratevm/src/com.oracle.svm.core/src/com/oracle/svm/core/JavaMainWrapper.java
+++ b/substratevm/src/com.oracle.svm.core/src/com/oracle/svm/core/JavaMainWrapper.java
@@ -67,6 +67,7 @@
 import com.oracle.svm.core.jdk.InternalVMMethod;
 import com.oracle.svm.core.jdk.RuntimeSupport;
 import com.oracle.svm.core.log.Log;
+import com.oracle.svm.core.os.VirtualMemoryProvider;
 import com.oracle.svm.core.sampler.ProfilingSampler;
 import com.oracle.svm.core.thread.JavaThreads;
 import com.oracle.svm.core.thread.PlatformThreads;
@@ -218,11 +219,19 @@ public static int run(int argc, CCharPointerPointer argv) {
         }
     }
 
+    private static final CGlobalData<CCharPointer> PAGE_SIZE_CHECK_FAIL_MESSAGE = CGlobalDataFactory
+                    .createCString("Image page size does not match the page size at run-time. Use -H:PageSize=[pagesize] to set appropriately.");
+
     @Uninterruptible(reason = "Thread state not setup yet.")
     private static int doRun(int argc, CCharPointerPointer argv) {
         try {
             CPUFeatureAccess cpuFeatureAccess = ImageSingletons.lookup(CPUFeatureAccess.class);
             cpuFeatureAccess.verifyHostSupportsArchitectureEarlyOrExit();
+            if (VirtualMemoryProvider.get().getGranularity().notEqual(SubstrateOptions.getPageSize())) {
+                CEntryPointActions.failFatally(CEntryPointErrors.PAGE_SIZE_CHECK_FAILED, PAGE_SIZE_CHECK_FAIL_MESSAGE.get());
+                return 1;
+            }
+
             // Create the isolate and attach the current C thread as the main Java thread.
             EnterCreateIsolateWithCArgumentsPrologue.enter(argc, argv);
             assert !VMThreads.wasStartedByCurrentIsolate(CurrentIsolate.getCurrentThread()) : "re-attach would cause issues otherwise";
diff --git a/substratevm/src/com.oracle.svm.core/src/com/oracle/svm/core/SubstrateOptions.java b/substratevm/src/com.oracle.svm.core/src/com/oracle/svm/core/SubstrateOptions.java
index 2ae67b2309ba..5f3a4048faa9 100644
--- a/substratevm/src/com.oracle.svm.core/src/com/oracle/svm/core/SubstrateOptions.java
+++ b/substratevm/src/com.oracle.svm.core/src/com/oracle/svm/core/SubstrateOptions.java
@@ -820,6 +820,7 @@ public ReportingSupport(String reportingPath) {
     @Option(help = "Define PageSize of a machine that runs the image. The default = 0 (== same as host machine page size)")//
     protected static final HostedOptionKey<Integer> PageSize = new HostedOptionKey<>(0);
 
+    @Fold
     public static int getPageSize() {
         int value = PageSize.getValue();
         if (value == 0) {
diff --git a/substratevm/src/com.oracle.svm.core/src/com/oracle/svm/core/c/function/CEntryPointErrors.java b/substratevm/src/com.oracle.svm.core/src/com/oracle/svm/core/c/function/CEntryPointErrors.java
index 772924d5353d..ebe28689bc82 100644
--- a/substratevm/src/com.oracle.svm.core/src/com/oracle/svm/core/c/function/CEntryPointErrors.java
+++ b/substratevm/src/com.oracle.svm.core/src/com/oracle/svm/core/c/function/CEntryPointErrors.java
@@ -125,6 +125,9 @@ private CEntryPointErrors() {
     @Description("Current target does not support the following CPU features that are required by the image.") //
     public static final int CPU_FEATURE_CHECK_FAILED = 23;
 
+    @Description("Image page size does not match the page size at run-time.") //
+    public static final int PAGE_SIZE_CHECK_FAILED = 24;
+
     public static String getDescription(int code) {
         String result = null;
         if (code >= 0 && code < DESCRIPTIONS.length) {
diff --git a/substratevm/src/com.oracle.svm.core/src/com/oracle/svm/core/graal/snippets/CEntryPointSnippets.java b/substratevm/src/com.oracle.svm.core/src/com/oracle/svm/core/graal/snippets/CEntryPointSnippets.java
index e99967118b0d..201cd05a4a6f 100644
--- a/substratevm/src/com.oracle.svm.core/src/com/oracle/svm/core/graal/snippets/CEntryPointSnippets.java
+++ b/substratevm/src/com.oracle.svm.core/src/com/oracle/svm/core/graal/snippets/CEntryPointSnippets.java
@@ -94,6 +94,7 @@
 import com.oracle.svm.core.log.Log;
 import com.oracle.svm.core.option.RuntimeOptionParser;
 import com.oracle.svm.core.os.MemoryProtectionProvider;
+import com.oracle.svm.core.os.VirtualMemoryProvider;
 import com.oracle.svm.core.snippets.SnippetRuntime;
 import com.oracle.svm.core.snippets.SnippetRuntime.SubstrateForeignCallDescriptor;
 import com.oracle.svm.core.snippets.SubstrateForeignCallTarget;
@@ -205,6 +206,9 @@ private static int createIsolate(CEntryPointCreateIsolateParameters parameters,
         if (cpuFeatureAccess.verifyHostSupportsArchitectureEarly() != 0) {
             return CEntryPointErrors.CPU_FEATURE_CHECK_FAILED;
         }
+        if (VirtualMemoryProvider.get().getGranularity().notEqual(SubstrateOptions.getPageSize())) {
+            return CEntryPointErrors.PAGE_SIZE_CHECK_FAILED;
+        }
         CLongPointer parsedArgs = StackValue.get(IsolateArgumentParser.getStructSize());
         IsolateArgumentParser.parse(parameters, parsedArgs);