diff --git a/src/ncp/ncp_host.cpp b/src/ncp/ncp_host.cpp
index 84055875bef..a1e20ddcfbc 100644
--- a/src/ncp/ncp_host.cpp
+++ b/src/ncp/ncp_host.cpp
@@ -145,6 +145,14 @@ void NcpHost::ScheduleMigration(const otOperationalDatasetTlvs &aPendingOpDatase
     }
 }
 
+void NcpHost::SetThreadEnabled(bool aEnabled, const AsyncResultReceiver aReceiver)
+{
+    OT_UNUSED_VARIABLE(aEnabled);
+
+    // TODO: Implement SetThreadEnabled under NCP mode.
+    mTaskRunner.Post([aReceiver](void) { aReceiver(OT_ERROR_NOT_IMPLEMENTED, "Not implemented!"); });
+}
+
 void NcpHost::Process(const MainloopContext &aMainloop)
 {
     mSpinelDriver.Process(&aMainloop);
diff --git a/src/ncp/ncp_host.hpp b/src/ncp/ncp_host.hpp
index 6bb18f77d07..b7d3d095f81 100644
--- a/src/ncp/ncp_host.hpp
+++ b/src/ncp/ncp_host.hpp
@@ -87,6 +87,7 @@ class NcpHost : public MainloopProcessor, public ThreadHost, public NcpNetworkPr
     void Leave(const AsyncResultReceiver &aReceiver) override;
     void ScheduleMigration(const otOperationalDatasetTlvs &aPendingOpDatasetTlvs,
                            const AsyncResultReceiver       aReceiver) override;
+    void SetThreadEnabled(bool aEnabled, const AsyncResultReceiver aReceiver) override;
     CoprocessorType GetCoprocessorType(void) override { return OT_COPROCESSOR_NCP; }
     const char     *GetCoprocessorVersion(void) override;
     const char     *GetInterfaceName(void) const override { return mConfig.mInterfaceName; }
diff --git a/src/ncp/rcp_host.cpp b/src/ncp/rcp_host.cpp
index a7eb6e526da..b4def76408f 100644
--- a/src/ncp/rcp_host.cpp
+++ b/src/ncp/rcp_host.cpp
@@ -295,6 +295,8 @@ void RcpHost::Deinit(void)
     OtNetworkProperties::SetInstance(nullptr);
     mThreadStateChangedCallbacks.clear();
     mResetHandlers.clear();
+
+    mSetThreadEnabledReceiver = nullptr;
 }
 
 void RcpHost::HandleStateChanged(otChangedFlags aFlags)
@@ -417,6 +419,56 @@ void RcpHost::ScheduleMigration(const otOperationalDatasetTlvs &aPendingOpDatase
     mTaskRunner.Post([aReceiver](void) { aReceiver(OT_ERROR_NOT_IMPLEMENTED, "Not implemented!"); });
 }
 
+void RcpHost::SetThreadEnabled(bool aEnabled, const AsyncResultReceiver aReceiver)
+{
+    otError error             = OT_ERROR_NONE;
+    bool    receiveResultHere = true;
+
+    VerifyOrExit(mInstance != nullptr, error = OT_ERROR_INVALID_STATE);
+    VerifyOrExit(mSetThreadEnabledReceiver == nullptr, error = OT_ERROR_BUSY);
+
+    if (aEnabled)
+    {
+        otOperationalDatasetTlvs datasetTlvs;
+
+        if (otDatasetGetActiveTlvs(mInstance, &datasetTlvs) != OT_ERROR_NOT_FOUND && datasetTlvs.mLength > 0 &&
+            otThreadGetDeviceRole(mInstance) == OT_DEVICE_ROLE_DISABLED)
+        {
+            SuccessOrExit(error = otIp6SetEnabled(mInstance, true));
+            SuccessOrExit(error = otThreadSetEnabled(mInstance, true));
+        }
+    }
+    else
+    {
+        SuccessOrExit(error = otThreadDetachGracefully(mInstance, DisableThreadAfterDetach, this));
+        mSetThreadEnabledReceiver = aReceiver;
+        receiveResultHere         = false;
+    }
+
+exit:
+    if (receiveResultHere)
+    {
+        mTaskRunner.Post([aReceiver, error](void) { aReceiver(error, ""); });
+    }
+}
+
+void RcpHost::DisableThreadAfterDetach(void *aContext)
+{
+    static_cast<RcpHost *>(aContext)->DisableThreadAfterDetach();
+}
+
+void RcpHost::DisableThreadAfterDetach(void)
+{
+    otError     error = OT_ERROR_NONE;
+    std::string errorMsg;
+
+    SuccessOrExit(error = otThreadSetEnabled(mInstance, false), errorMsg = "Failed to disable Thread stack");
+    SuccessOrExit(error = otIp6SetEnabled(mInstance, false), errorMsg = "Failed to disable Thread interface");
+
+exit:
+    SafeInvokeAndClear(mSetThreadEnabledReceiver, error, errorMsg);
+}
+
 /*
  * Provide, if required an "otPlatLog()" function
  */
diff --git a/src/ncp/rcp_host.hpp b/src/ncp/rcp_host.hpp
index 79f441a16af..bdf3118d0e5 100644
--- a/src/ncp/rcp_host.hpp
+++ b/src/ncp/rcp_host.hpp
@@ -207,6 +207,7 @@ class RcpHost : public MainloopProcessor, public ThreadHost, public OtNetworkPro
     void Leave(const AsyncResultReceiver &aRecevier) override;
     void ScheduleMigration(const otOperationalDatasetTlvs &aPendingOpDatasetTlvs,
                            const AsyncResultReceiver       aReceiver) override;
+    void SetThreadEnabled(bool aEnabled, const AsyncResultReceiver aReceiver) override;
 
     CoprocessorType GetCoprocessorType(void) override
     {
@@ -219,6 +220,15 @@ class RcpHost : public MainloopProcessor, public ThreadHost, public OtNetworkPro
     }
 
 private:
+    static void SafeInvokeAndClear(AsyncResultReceiver &aReceiver, otError aError, const std::string &aErrorInfo = "")
+    {
+        if (aReceiver)
+        {
+            aReceiver(aError, aErrorInfo);
+            aReceiver = nullptr;
+        }
+    }
+
     static void HandleStateChanged(otChangedFlags aFlags, void *aContext)
     {
         static_cast<RcpHost *>(aContext)->HandleStateChanged(aFlags);
@@ -238,6 +248,9 @@ class RcpHost : public MainloopProcessor, public ThreadHost, public OtNetworkPro
     void        HandleBackboneRouterNdProxyEvent(otBackboneRouterNdProxyEvent aEvent, const otIp6Address *aAddress);
 #endif
 
+    static void DisableThreadAfterDetach(void *aContext);
+    void        DisableThreadAfterDetach(void);
+
     bool IsAutoAttachEnabled(void);
     void DisableAutoAttach(void);
 
@@ -252,6 +265,8 @@ class RcpHost : public MainloopProcessor, public ThreadHost, public OtNetworkPro
     std::vector<ThreadStateChangedCallback>    mThreadStateChangedCallbacks;
     bool                                       mEnableAutoAttach = false;
 
+    AsyncResultReceiver mSetThreadEnabledReceiver;
+
 #if OTBR_ENABLE_FEATURE_FLAGS
     // The applied FeatureFlagList in ApplyFeatureFlagList call, used for debugging purpose.
     std::string mAppliedFeatureFlagListBytes;
diff --git a/src/ncp/thread_host.hpp b/src/ncp/thread_host.hpp
index 30b8e45a03d..f0677bcdc37 100644
--- a/src/ncp/thread_host.hpp
+++ b/src/ncp/thread_host.hpp
@@ -136,6 +136,20 @@ class ThreadHost : virtual public NetworkProperties
     virtual void ScheduleMigration(const otOperationalDatasetTlvs &aPendingOpDatasetTlvs,
                                    const AsyncResultReceiver       aReceiver) = 0;
 
+    /**
+     * This method enables/disables the Thread network.
+     *
+     * 1. If there is an ongoing 'SetThreadEnabled' operation, no action will be taken and @p aReceiver
+     *    will be invoked with error OT_ERROR_BUSY.
+     * 2. If the host hasn't been initialized, @p aReceiver will be invoked with error OT_ERROR_INVALID_STATE.
+     * 3. When @p aEnabled is false, this method will first trigger a graceful detach and then disable Thread
+     *    network interface and the stack.
+     *
+     * @param[in] aEnabled  true to enable and false to disable.
+     * @param[in] aReceiver  A receiver to get the async result of this operation.
+     */
+    virtual void SetThreadEnabled(bool aEnabled, const AsyncResultReceiver aReceiver) = 0;
+
     /**
      * Returns the co-processor type.
      */