diff --git a/CHANGELOG.md b/CHANGELOG.md
index 4a8dca630e52..62c071bc2abb 100644
--- a/CHANGELOG.md
+++ b/CHANGELOG.md
@@ -82,6 +82,7 @@ Inspired from [Keep a Changelog](https://keepachangelog.com/en/1.0.0/)
 - [Workspace] Add permission control logic ([#6052](https://github.com/opensearch-project/OpenSearch-Dashboards/pull/6052))
 - [Multiple Datasource] Add default icon for selectable component and make sure the default datasource shows automatically ([#6327](https://github.com/opensearch-project/OpenSearch-Dashboards/pull/6327))
 - [Multiple Datasource] Pass selected data sources to plugin consumers when the multi-select component initially loads ([#6333](https://github.com/opensearch-project/OpenSearch-Dashboards/pull/6333))
+- [Mulitple Datasource] Add multi data source support to TSVB ([#6298](https://github.com/opensearch-project/OpenSearch-Dashboards/pull/6298))
 - [Multiple Datasource] Add installedPlugins list to data source saved object ([#6348](https://github.com/opensearch-project/OpenSearch-Dashboards/pull/6348))
 - [Multiple Datasource] Add default icon in multi-selectable picker ([#6357](https://github.com/opensearch-project/OpenSearch-Dashboards/pull/6357))
 - [Workspace] Add APIs to support plugin state in request ([#6303](https://github.com/opensearch-project/OpenSearch-Dashboards/pull/6303))
diff --git a/src/plugins/data/server/index.ts b/src/plugins/data/server/index.ts
index 46c2b1ca0477..4bc3ad62a4ae 100644
--- a/src/plugins/data/server/index.ts
+++ b/src/plugins/data/server/index.ts
@@ -145,6 +145,7 @@ export {
   FieldDescriptor as IndexPatternFieldDescriptor,
   shouldReadFieldFromDocValues, // used only in logstash_fields fixture
   FieldDescriptor,
+  decideClient,
 } from './index_patterns';
 
 export {
diff --git a/src/plugins/data/server/index_patterns/index.ts b/src/plugins/data/server/index_patterns/index.ts
index b2e832294e41..771aa9c09ab8 100644
--- a/src/plugins/data/server/index_patterns/index.ts
+++ b/src/plugins/data/server/index_patterns/index.ts
@@ -31,3 +31,4 @@
 export * from './utils';
 export { IndexPatternsFetcher, FieldDescriptor, shouldReadFieldFromDocValues } from './fetcher';
 export { IndexPatternsService, IndexPatternsServiceStart } from './index_patterns_service';
+export { decideClient } from './routes';
diff --git a/src/plugins/data/server/index_patterns/routes.ts b/src/plugins/data/server/index_patterns/routes.ts
index 3adc1970dd81..8b3c7139ffc0 100644
--- a/src/plugins/data/server/index_patterns/routes.ts
+++ b/src/plugins/data/server/index_patterns/routes.ts
@@ -155,7 +155,7 @@ export function registerRoutes(http: HttpServiceSetup) {
   );
 }
 
-const decideClient = async (
+export const decideClient = async (
   context: RequestHandlerContext,
   request: any
 ): Promise<LegacyAPICaller> => {
diff --git a/src/plugins/data_source_management/public/components/data_source_selector/data_source_selector.tsx b/src/plugins/data_source_management/public/components/data_source_selector/data_source_selector.tsx
index bfe02b7288a2..8d2a90943b9f 100644
--- a/src/plugins/data_source_management/public/components/data_source_selector/data_source_selector.tsx
+++ b/src/plugins/data_source_management/public/components/data_source_selector/data_source_selector.tsx
@@ -34,6 +34,7 @@ export interface DataSourceSelectorProps {
   dataSourceFilter?: (dataSource: SavedObject<DataSourceAttributes>) => boolean;
   compressed?: boolean;
   uiSettings?: IUiSettingsClient;
+  isClearable?: boolean;
 }
 
 interface DataSourceSelectorState {
@@ -202,6 +203,7 @@ export class DataSourceSelector extends React.Component<
 
     return (
       <EuiComboBox
+        isClearable={this.props.isClearable}
         aria-label={
           placeholderText
             ? i18n.translate('dataSourceSelectorComboBoxAriaLabel', {
diff --git a/src/plugins/data_source_management/public/components/data_source_selector/index.ts b/src/plugins/data_source_management/public/components/data_source_selector/index.ts
index a1d1d97b9828..ea44c761e1d4 100644
--- a/src/plugins/data_source_management/public/components/data_source_selector/index.ts
+++ b/src/plugins/data_source_management/public/components/data_source_selector/index.ts
@@ -3,4 +3,4 @@
  * SPDX-License-Identifier: Apache-2.0
  */
 
-export { DataSourceSelector } from './data_source_selector';
+export { DataSourceSelector, DataSourceOption } from './data_source_selector';
diff --git a/src/plugins/data_source_management/public/index.ts b/src/plugins/data_source_management/public/index.ts
index 471792ddd726..da7fd8992459 100644
--- a/src/plugins/data_source_management/public/index.ts
+++ b/src/plugins/data_source_management/public/index.ts
@@ -12,7 +12,7 @@ export function plugin() {
 }
 
 export { DataSourceManagementPluginStart } from './types';
-export { DataSourceSelector } from './components/data_source_selector';
+export { DataSourceSelector, DataSourceOption } from './components/data_source_selector';
 export { DataSourceMenu } from './components/data_source_menu';
 export { DataSourceManagementPlugin, DataSourceManagementPluginSetup } from './plugin';
 export {
diff --git a/src/plugins/vis_type_timeseries/common/constants.ts b/src/plugins/vis_type_timeseries/common/constants.ts
index f97c4aaae3ad..279b9298f197 100644
--- a/src/plugins/vis_type_timeseries/common/constants.ts
+++ b/src/plugins/vis_type_timeseries/common/constants.ts
@@ -30,3 +30,4 @@
 
 export const MAX_BUCKETS_SETTING = 'metrics:max_buckets';
 export const INDEXES_SEPARATOR = ',';
+export const DATA_SOURCE_ID_KEY = 'data_source_id';
diff --git a/src/plugins/vis_type_timeseries/common/vis_schema.ts b/src/plugins/vis_type_timeseries/common/vis_schema.ts
index c6c79b165727..53d7e35519f5 100644
--- a/src/plugins/vis_type_timeseries/common/vis_schema.ts
+++ b/src/plugins/vis_type_timeseries/common/vis_schema.ts
@@ -238,6 +238,7 @@ export const panel = schema.object({
   ignore_global_filters: numberOptional,
   ignore_global_filter: numberOptional,
   index_pattern: stringRequired,
+  data_source_id: stringOptionalNullable,
   interval: stringRequired,
   isModelInvalid: schema.maybe(schema.boolean()),
   legend_position: stringOptionalNullable,
diff --git a/src/plugins/vis_type_timeseries/opensearch_dashboards.json b/src/plugins/vis_type_timeseries/opensearch_dashboards.json
index 92441a8a2e4d..23aa8049928b 100644
--- a/src/plugins/vis_type_timeseries/opensearch_dashboards.json
+++ b/src/plugins/vis_type_timeseries/opensearch_dashboards.json
@@ -5,6 +5,6 @@
   "server": true,
   "ui": true,
   "requiredPlugins": ["charts", "data", "expressions", "visualizations"],
-  "optionalPlugins": ["usageCollection"],
+  "optionalPlugins": ["usageCollection", "dataSourceManagement", "dataSource"],
   "requiredBundles": ["opensearchDashboardsUtils", "opensearchDashboardsReact"]
 }
diff --git a/src/plugins/vis_type_timeseries/public/application/components/annotations_editor.js b/src/plugins/vis_type_timeseries/public/application/components/annotations_editor.js
index 8a473c396511..f75284ff7439 100644
--- a/src/plugins/vis_type_timeseries/public/application/components/annotations_editor.js
+++ b/src/plugins/vis_type_timeseries/public/application/components/annotations_editor.js
@@ -55,6 +55,7 @@ import {
   EuiText,
 } from '@elastic/eui';
 import { FormattedMessage } from '@osd/i18n/react';
+import { i18n } from '@osd/i18n';
 
 function newAnnotation() {
   return {
@@ -131,9 +132,13 @@ export class AnnotationsEditor extends Component {
                   label={
                     <FormattedMessage
                       id="visTypeTimeseries.annotationsEditor.indexPatternLabel"
-                      defaultMessage="Index pattern (required)"
+                      defaultMessage="Index name (required)"
                     />
                   }
+                  helpText={i18n.translate('visTypeTimeseries.indexPattern.searchByIndex', {
+                    defaultMessage:
+                      'Use an asterisk (*) to match multiple indices. Spaces and the characters , /, ?, ", <, >, | are not allowed.',
+                  })}
                   fullWidth
                 >
                   <EuiFieldText
diff --git a/src/plugins/vis_type_timeseries/public/application/components/index_pattern.js b/src/plugins/vis_type_timeseries/public/application/components/index_pattern.js
index b28be12ffc33..da05e3e90138 100644
--- a/src/plugins/vis_type_timeseries/public/application/components/index_pattern.js
+++ b/src/plugins/vis_type_timeseries/public/application/components/index_pattern.js
@@ -41,6 +41,12 @@ import {
   EuiText,
 } from '@elastic/eui';
 import { FieldSelect } from './aggs/field_select';
+import { createDataSourcePickerHandler } from './lib/create_data_source_change_handler';
+import {
+  getSavedObjectsClient,
+  getNotifications,
+  getDataSourceManagementSetup,
+} from '../../services';
 import { createSelectHandler } from './lib/create_select_handler';
 import { createTextHandler } from './lib/create_text_handler';
 import { YesNo } from './yes_no';
@@ -112,6 +118,14 @@ export const IndexPattern = ({ fields, prefix, onChange, disabled, model: _model
   };
 
   const model = { ...defaults, ..._model };
+
+  const dataSourceManagementEnabled =
+    !!getDataSourceManagementSetup().dataSourceManagement || false;
+  const handleDataSourceSelectChange = createDataSourcePickerHandler(onChange);
+  const DataSourceSelector = dataSourceManagementEnabled
+    ? getDataSourceManagementSetup().dataSourceManagement.ui.DataSourceSelector
+    : undefined;
+
   const isDefaultIndexPatternUsed = model.default_index_pattern && !model[indexPatternName];
   const intervalValidation = validateIntervalValue(model[intervalName]);
   const selectedTimeRangeOption = timeRangeOptions.find(
@@ -157,18 +171,47 @@ export const IndexPattern = ({ fields, prefix, onChange, disabled, model: _model
           </EuiFlexItem>
         </EuiFlexGroup>
       )}
+      {!!dataSourceManagementEnabled && (
+        <EuiFlexGroup>
+          <EuiFlexItem>
+            <EuiFormRow
+              id={htmlId('dataSource')}
+              label={i18n.translate('visTypeTimeseries.indexPattern.dataSourceLabel', {
+                defaultMessage: 'Data source',
+              })}
+            >
+              <DataSourceSelector
+                savedObjectsClient={getSavedObjectsClient().client}
+                notifications={getNotifications().toasts}
+                onSelectedDataSource={handleDataSourceSelectChange}
+                defaultOption={
+                  model.data_source_id !== undefined ? [{ id: model.data_source_id }] : undefined
+                }
+                disabled={false}
+                fullWidth={false}
+                removePrepend={true}
+                isClearable={false}
+              />
+            </EuiFormRow>
+          </EuiFlexItem>
+        </EuiFlexGroup>
+      )}
       <EuiFlexGroup>
         <EuiFlexItem>
           <EuiFormRow
             id={htmlId('indexPattern')}
             label={i18n.translate('visTypeTimeseries.indexPatternLabel', {
-              defaultMessage: 'Index pattern',
+              defaultMessage: 'Index name',
             })}
             helpText={
-              isDefaultIndexPatternUsed &&
-              i18n.translate('visTypeTimeseries.indexPattern.searchByDefaultIndex', {
-                defaultMessage: 'Default index pattern is used. To query all indexes use *',
-              })
+              isDefaultIndexPatternUsed
+                ? i18n.translate('visTypeTimeseries.indexPattern.searchByDefaultIndex', {
+                    defaultMessage: 'Default index pattern is used. To query all indexes use *',
+                  })
+                : i18n.translate('visTypeTimeseries.indexPattern.searchByIndex', {
+                    defaultMessage:
+                      'Use an asterisk (*) to match multiple indices. Spaces and the characters , /, ?, ", <, >, | are not allowed.',
+                  })
             }
           >
             <EuiFieldText
diff --git a/src/plugins/vis_type_timeseries/public/application/components/lib/create_data_source_change_handler.test.ts b/src/plugins/vis_type_timeseries/public/application/components/lib/create_data_source_change_handler.test.ts
new file mode 100644
index 000000000000..2a95a2756b50
--- /dev/null
+++ b/src/plugins/vis_type_timeseries/public/application/components/lib/create_data_source_change_handler.test.ts
@@ -0,0 +1,49 @@
+/*
+ * Copyright OpenSearch Contributors
+ * SPDX-License-Identifier: Apache-2.0
+ */
+
+import { createDataSourcePickerHandler } from './create_data_source_change_handler';
+
+describe('createDataSourcePickerHandler()', () => {
+  let handleChange: jest.Mock<any, any>;
+  let changeHandler: (selectedOptions: []) => void;
+
+  beforeEach(() => {
+    handleChange = jest.fn();
+    changeHandler = createDataSourcePickerHandler(handleChange);
+  });
+
+  test.each([
+    {
+      id: undefined,
+    },
+    {},
+  ])(
+    'calls handleChange() and sets data_source_id to undefined if id cannot be found or is undefined',
+    ({ id }) => {
+      // @ts-ignore
+      changeHandler([{ id }]);
+      expect(handleChange.mock.calls.length).toEqual(1);
+      expect(handleChange.mock.calls[0][0]).toEqual({
+        data_source_id: undefined,
+      });
+    }
+  );
+
+  test.each([
+    {
+      id: '',
+    },
+    {
+      id: 'foo',
+    },
+  ])('calls handleChange() function with partial and updates the data_source_id', ({ id }) => {
+    // @ts-ignore
+    changeHandler([{ id }]);
+    expect(handleChange.mock.calls.length).toEqual(1);
+    expect(handleChange.mock.calls[0][0]).toEqual({
+      data_source_id: id,
+    });
+  });
+});
diff --git a/src/plugins/vis_type_timeseries/public/application/components/lib/create_data_source_change_handler.ts b/src/plugins/vis_type_timeseries/public/application/components/lib/create_data_source_change_handler.ts
new file mode 100644
index 000000000000..5fa18d74c5b3
--- /dev/null
+++ b/src/plugins/vis_type_timeseries/public/application/components/lib/create_data_source_change_handler.ts
@@ -0,0 +1,16 @@
+/*
+ * Copyright OpenSearch Contributors
+ * SPDX-License-Identifier: Apache-2.0
+ */
+import _ from 'lodash';
+
+import { PanelSchema } from 'src/plugins/vis_type_timeseries/common/types';
+import { DATA_SOURCE_ID_KEY } from '../../../../common/constants';
+
+export const createDataSourcePickerHandler = (handleChange: (e: PanelSchema) => void) => {
+  return (selectedOptions: []): void => {
+    return handleChange?.({
+      [DATA_SOURCE_ID_KEY]: _.get(selectedOptions, '[0].id', undefined),
+    } as PanelSchema);
+  };
+};
diff --git a/src/plugins/vis_type_timeseries/public/application/components/vis_editor.js b/src/plugins/vis_type_timeseries/public/application/components/vis_editor.js
index e3d78bd0a824..c91d1f084f91 100644
--- a/src/plugins/vis_type_timeseries/public/application/components/vis_editor.js
+++ b/src/plugins/vis_type_timeseries/public/application/components/vis_editor.js
@@ -41,6 +41,7 @@ import { createBrushHandler } from '../lib/create_brush_handler';
 import { fetchFields } from '../lib/fetch_fields';
 import { extractIndexPatterns } from '../../../../../plugins/vis_type_timeseries/common/extract_index_patterns';
 import { getSavedObjectsClient, getUISettings, getDataStart, getCoreStart } from '../../services';
+import { DATA_SOURCE_ID_KEY } from '../../../common/constants';
 
 import { CoreStartContextProvider } from '../contexts/query_input_bar_context';
 import { OpenSearchDashboardsContextProvider } from '../../../../../plugins/opensearch_dashboards_react/public';
@@ -113,9 +114,13 @@ export class VisEditor extends Component {
     }
 
     if (this.props.isEditorMode) {
+      const dataSourceId = nextModel[DATA_SOURCE_ID_KEY] || undefined;
       const extractedIndexPatterns = extractIndexPatterns(nextModel);
-      if (!isEqual(this.state.extractedIndexPatterns, extractedIndexPatterns)) {
-        fetchFields(extractedIndexPatterns).then((visFields) =>
+      if (
+        !isEqual(this.state.extractedIndexPatterns, extractedIndexPatterns) ||
+        !isEqual(this.state.model[DATA_SOURCE_ID_KEY], dataSourceId)
+      ) {
+        fetchFields(extractedIndexPatterns, dataSourceId).then((visFields) =>
           this.setState({
             visFields,
             extractedIndexPatterns,
diff --git a/src/plugins/vis_type_timeseries/public/application/lib/fetch_fields.js b/src/plugins/vis_type_timeseries/public/application/lib/fetch_fields.js
index cac4c910fee4..8aa9bb618cad 100644
--- a/src/plugins/vis_type_timeseries/public/application/lib/fetch_fields.js
+++ b/src/plugins/vis_type_timeseries/public/application/lib/fetch_fields.js
@@ -30,9 +30,10 @@
 
 import { i18n } from '@osd/i18n';
 import { extractIndexPatterns } from '../../../common/extract_index_patterns';
+import { DATA_SOURCE_ID_KEY } from '../../../common/constants';
 import { getCoreStart } from '../../services';
 
-export async function fetchFields(indexPatterns = ['*']) {
+export async function fetchFields(indexPatterns = ['*'], dataSourceId = undefined) {
   const patterns = Array.isArray(indexPatterns) ? indexPatterns : [indexPatterns];
   try {
     const indexFields = await Promise.all(
@@ -40,6 +41,7 @@ export async function fetchFields(indexPatterns = ['*']) {
         return getCoreStart().http.get('/api/metrics/fields', {
           query: {
             index: pattern,
+            data_source: dataSourceId,
           },
         });
       })
@@ -62,7 +64,8 @@ export async function fetchFields(indexPatterns = ['*']) {
 }
 
 export async function fetchIndexPatternFields({ params, fields = {} }) {
+  const dataSourceId = params[DATA_SOURCE_ID_KEY] || undefined;
   const indexPatterns = extractIndexPatterns(params, fields);
 
-  return await fetchFields(indexPatterns);
+  return await fetchFields(indexPatterns, dataSourceId);
 }
diff --git a/src/plugins/vis_type_timeseries/public/plugin.ts b/src/plugins/vis_type_timeseries/public/plugin.ts
index da565a160164..0220a5320422 100644
--- a/src/plugins/vis_type_timeseries/public/plugin.ts
+++ b/src/plugins/vis_type_timeseries/public/plugin.ts
@@ -36,6 +36,8 @@ import {
   CoreStart,
   Plugin,
 } from 'opensearch-dashboards/public';
+import { DataSourceManagementPluginSetup } from 'src/plugins/data_source_management/public';
+import { DataSourcePluginSetup } from 'src/plugins/data_source/public';
 import { Plugin as ExpressionsPublicPlugin } from '../../expressions/public';
 import { VisualizationsSetup } from '../../visualizations/public';
 
@@ -49,6 +51,8 @@ import {
   setCoreStart,
   setDataStart,
   setChartsSetup,
+  setDataSourceManagementSetup,
+  setNotifications,
 } from './services';
 import { DataPublicPluginStart } from '../../data/public';
 import { ChartsPluginSetup } from '../../charts/public';
@@ -58,6 +62,8 @@ export interface MetricsPluginSetupDependencies {
   expressions: ReturnType<ExpressionsPublicPlugin['setup']>;
   visualizations: VisualizationsSetup;
   charts: ChartsPluginSetup;
+  dataSourceManagement?: DataSourceManagementPluginSetup;
+  dataSource?: DataSourcePluginSetup;
 }
 
 /** @internal */
@@ -75,12 +81,19 @@ export class MetricsPlugin implements Plugin<Promise<void>, void> {
 
   public async setup(
     core: CoreSetup,
-    { expressions, visualizations, charts }: MetricsPluginSetupDependencies
+    {
+      expressions,
+      visualizations,
+      charts,
+      dataSourceManagement,
+      dataSource,
+    }: MetricsPluginSetupDependencies
   ) {
     expressions.registerFunction(createMetricsFn);
     setUISettings(core.uiSettings);
     setChartsSetup(charts);
     visualizations.createReactVisualization(metricsVisDefinition);
+    setDataSourceManagementSetup({ dataSourceManagement });
   }
 
   public start(core: CoreStart, { data }: MetricsPluginStartDependencies) {
@@ -89,5 +102,6 @@ export class MetricsPlugin implements Plugin<Promise<void>, void> {
     setFieldFormats(data.fieldFormats);
     setDataStart(data);
     setCoreStart(core);
+    setNotifications(core.notifications);
   }
 }
diff --git a/src/plugins/vis_type_timeseries/public/services.ts b/src/plugins/vis_type_timeseries/public/services.ts
index 15532bc4fd6f..5f54ac3e7546 100644
--- a/src/plugins/vis_type_timeseries/public/services.ts
+++ b/src/plugins/vis_type_timeseries/public/services.ts
@@ -28,7 +28,14 @@
  * under the License.
  */
 
-import { I18nStart, SavedObjectsStart, IUiSettingsClient, CoreStart } from 'src/core/public';
+import {
+  I18nStart,
+  SavedObjectsStart,
+  IUiSettingsClient,
+  CoreStart,
+  NotificationsStart,
+} from 'src/core/public';
+import { DataSourceManagementPluginSetup } from 'src/plugins/data_source_management/public';
 import { createGetterSetter } from '../../opensearch_dashboards_utils/public';
 import { ChartsPluginSetup } from '../../charts/public';
 import { DataPublicPluginStart } from '../../data/public';
@@ -52,3 +59,11 @@ export const [getI18n, setI18n] = createGetterSetter<I18nStart>('I18n');
 export const [getChartsSetup, setChartsSetup] = createGetterSetter<ChartsPluginSetup>(
   'ChartsPluginSetup'
 );
+
+export const [getDataSourceManagementSetup, setDataSourceManagementSetup] = createGetterSetter<{
+  dataSourceManagement: DataSourceManagementPluginSetup | undefined;
+}>('DataSourceManagementSetup');
+
+export const [getNotifications, setNotifications] = createGetterSetter<NotificationsStart>(
+  'Notifications'
+);
diff --git a/src/plugins/vis_type_timeseries/server/lib/get_fields.ts b/src/plugins/vis_type_timeseries/server/lib/get_fields.ts
index 1752d3f91f86..56a58b43b45e 100644
--- a/src/plugins/vis_type_timeseries/server/lib/get_fields.ts
+++ b/src/plugins/vis_type_timeseries/server/lib/get_fields.ts
@@ -37,6 +37,7 @@ import {
   indexPatterns,
   IndexPatternFieldDescriptor,
   IndexPatternsFetcher,
+  decideClient,
 } from '../../../data/server';
 import { ReqFacade } from './search_strategies/strategies/abstract_search_strategy';
 
@@ -50,15 +51,15 @@ export async function getFields(
   // removes the need to refactor many layers of dependencies on "req", and instead just augments the top
   // level object passed from here. The layers should be refactored fully at some point, but for now
   // this works and we are still using the New Platform services for these vis data portions.
+  const client = await decideClient(requestContext, request);
+
   const reqFacade: ReqFacade = {
     requestContext,
     ...request,
     framework,
     payload: {},
     pre: {
-      indexPatternsService: new IndexPatternsFetcher(
-        requestContext.core.opensearch.legacy.client.callAsCurrentUser
-      ),
+      indexPatternsService: new IndexPatternsFetcher(client),
     },
     getUiSettingsService: () => requestContext.core.uiSettings.client,
     getSavedObjectsClient: () => requestContext.core.savedObjects.client,
diff --git a/src/plugins/vis_type_timeseries/server/lib/search_strategies/strategies/abstract_search_strategy.test.js b/src/plugins/vis_type_timeseries/server/lib/search_strategies/strategies/abstract_search_strategy.test.js
index fa130462e78d..068a7ef06c04 100644
--- a/src/plugins/vis_type_timeseries/server/lib/search_strategies/strategies/abstract_search_strategy.test.js
+++ b/src/plugins/vis_type_timeseries/server/lib/search_strategies/strategies/abstract_search_strategy.test.js
@@ -65,7 +65,7 @@ describe('AbstractSearchStrategy', () => {
     });
   });
 
-  test('should return response', async () => {
+  test('should return response for local cluster queries', async () => {
     const searches = [{ body: 'body', index: 'index' }];
     const searchFn = jest.fn().mockReturnValue(Promise.resolve({}));
 
@@ -107,4 +107,50 @@ describe('AbstractSearchStrategy', () => {
       }
     );
   });
+
+  test('should return response for datasource query', async () => {
+    const searches = [{ body: 'body', index: 'index' }];
+    const searchFn = jest.fn().mockReturnValue(Promise.resolve({}));
+
+    const responses = await abstractSearchStrategy.search(
+      {
+        requestContext: {},
+        framework: {
+          core: {
+            getStartServices: jest.fn().mockReturnValue(
+              Promise.resolve([
+                {},
+                {
+                  data: {
+                    search: {
+                      search: searchFn,
+                    },
+                  },
+                },
+              ])
+            ),
+          },
+        },
+      },
+      searches,
+      {},
+      'some-data-source-id'
+    );
+
+    expect(responses).toEqual([{}]);
+    expect(searchFn).toHaveBeenCalledWith(
+      {},
+      {
+        dataSourceId: 'some-data-source-id',
+        params: {
+          body: 'body',
+          index: 'index',
+        },
+        indexType: undefined,
+      },
+      {
+        strategy: 'opensearch',
+      }
+    );
+  });
 });
diff --git a/src/plugins/vis_type_timeseries/server/lib/search_strategies/strategies/abstract_search_strategy.ts b/src/plugins/vis_type_timeseries/server/lib/search_strategies/strategies/abstract_search_strategy.ts
index 6b69628353ac..7c333fad7f73 100644
--- a/src/plugins/vis_type_timeseries/server/lib/search_strategies/strategies/abstract_search_strategy.ts
+++ b/src/plugins/vis_type_timeseries/server/lib/search_strategies/strategies/abstract_search_strategy.ts
@@ -66,7 +66,7 @@ export class AbstractSearchStrategy {
     this.additionalParams = additionalParams;
   }
 
-  async search(req: ReqFacade, bodies: any[], options = {}) {
+  async search(req: ReqFacade, bodies: any[], options = {}, dataSourceId?: string) {
     const [, deps] = await req.framework.core.getStartServices();
     const requests: any[] = [];
     bodies.forEach((body) => {
@@ -74,6 +74,7 @@ export class AbstractSearchStrategy {
         deps.data.search.search(
           req.requestContext,
           {
+            ...(!!dataSourceId && { dataSourceId }),
             params: {
               ...body,
               ...this.additionalParams,
diff --git a/src/plugins/vis_type_timeseries/server/lib/vis_data/get_annotations.js b/src/plugins/vis_type_timeseries/server/lib/vis_data/get_annotations.js
index 16b526d1ba2e..3dd88b830346 100644
--- a/src/plugins/vis_type_timeseries/server/lib/vis_data/get_annotations.js
+++ b/src/plugins/vis_type_timeseries/server/lib/vis_data/get_annotations.js
@@ -54,6 +54,7 @@ export async function getAnnotations({
   const annotations = panel.annotations.filter(validAnnotation);
   const lastSeriesTimestamp = getLastSeriesTimestamp(series);
   const handleAnnotationResponseBy = handleAnnotationResponse(lastSeriesTimestamp);
+  const panelDataSourceId = panel.data_source_id;
 
   const bodiesPromises = annotations.map((annotation) =>
     getAnnotationRequestParams(req, panel, annotation, opensearchQueryConfig, capabilities)
@@ -67,7 +68,7 @@ export async function getAnnotations({
   if (!searches.length) return { responses: [] };
 
   try {
-    const data = await searchStrategy.search(req, searches);
+    const data = await searchStrategy.search(req, searches, {}, panelDataSourceId);
 
     return annotations.reduce((acc, annotation, index) => {
       acc[annotation.id] = handleAnnotationResponseBy(data[index].rawResponse, annotation);
diff --git a/src/plugins/vis_type_timeseries/server/lib/vis_data/get_series_data.js b/src/plugins/vis_type_timeseries/server/lib/vis_data/get_series_data.js
index a5c8a239d2b0..59d445f93324 100644
--- a/src/plugins/vis_type_timeseries/server/lib/vis_data/get_series_data.js
+++ b/src/plugins/vis_type_timeseries/server/lib/vis_data/get_series_data.js
@@ -41,6 +41,7 @@ export async function getSeriesData(req, panel) {
     capabilities,
   } = await req.framework.searchStrategyRegistry.getViableStrategyForPanel(req, panel);
   const opensearchQueryConfig = await getOpenSearchQueryConfig(req);
+  const panelDataSourceId = panel.data_source_id;
   const meta = {
     type: panel.type,
     uiRestrictions: capabilities.uiRestrictions,
@@ -56,7 +57,7 @@ export async function getSeriesData(req, panel) {
       []
     );
 
-    const data = await searchStrategy.search(req, searches);
+    const data = await searchStrategy.search(req, searches, {}, panelDataSourceId);
 
     const handleResponseBodyFn = handleResponseBody(panel);
 
diff --git a/src/plugins/vis_type_timeseries/server/lib/vis_data/get_table_data.js b/src/plugins/vis_type_timeseries/server/lib/vis_data/get_table_data.js
index 0b744638c3d8..20dfa06c1a78 100644
--- a/src/plugins/vis_type_timeseries/server/lib/vis_data/get_table_data.js
+++ b/src/plugins/vis_type_timeseries/server/lib/vis_data/get_table_data.js
@@ -37,6 +37,7 @@ import { getIndexPatternObject } from './helpers/get_index_pattern';
 
 export async function getTableData(req, panel) {
   const panelIndexPattern = panel.index_pattern;
+  const panelDataSourceId = panel.data_source_id;
 
   const {
     searchStrategy,
@@ -58,12 +59,17 @@ export async function getTableData(req, panel) {
       indexPatternObject,
       capabilities
     );
-    const [resp] = await searchStrategy.search(req, [
-      {
-        body,
-        index: panelIndexPattern,
-      },
-    ]);
+    const [resp] = await searchStrategy.search(
+      req,
+      [
+        {
+          body,
+          index: panelIndexPattern,
+        },
+      ],
+      {},
+      panelDataSourceId
+    );
 
     const buckets = get(
       resp.rawResponse ? resp.rawResponse : resp,
diff --git a/src/plugins/vis_type_timeseries/server/plugin.ts b/src/plugins/vis_type_timeseries/server/plugin.ts
index 654c85d452b1..af95e2e6b5dc 100644
--- a/src/plugins/vis_type_timeseries/server/plugin.ts
+++ b/src/plugins/vis_type_timeseries/server/plugin.ts
@@ -40,6 +40,7 @@ import {
 } from 'src/core/server';
 import { Observable } from 'rxjs';
 import { Server } from '@hapi/hapi';
+import { DataSourcePluginSetup } from 'src/plugins/data_source/server';
 import { VisTypeTimeseriesConfig } from './config';
 import { getVisData, GetVisData, GetVisDataOptions } from './lib/get_vis_data';
 import { ValidationTelemetryService } from './validation_telemetry';
@@ -57,6 +58,7 @@ export interface LegacySetup {
 
 interface VisTypeTimeseriesPluginSetupDependencies {
   usageCollection?: UsageCollectionSetup;
+  dataSource?: DataSourcePluginSetup;
 }
 
 interface VisTypeTimeseriesPluginStartDependencies {
diff --git a/src/plugins/vis_type_timeseries/server/routes/fields.ts b/src/plugins/vis_type_timeseries/server/routes/fields.ts
index bff34ee159f5..80a04918c517 100644
--- a/src/plugins/vis_type_timeseries/server/routes/fields.ts
+++ b/src/plugins/vis_type_timeseries/server/routes/fields.ts
@@ -38,12 +38,17 @@ export const fieldsRoutes = (framework: Framework) => {
     {
       path: '/api/metrics/fields',
       validate: {
-        query: schema.object({ index: schema.string() }),
+        query: schema.object({
+          index: schema.string(),
+          data_source: schema.maybe(schema.string()),
+        }),
       },
     },
     async (context, req, res) => {
       try {
-        return res.ok({ body: await getFields(context, req, framework, req.query.index) });
+        return res.ok({
+          body: await getFields(context, req, framework, req.query.index),
+        });
       } catch (err) {
         if (isBoom(err) && err.output.statusCode === 401) {
           return res.customError({