diff --git a/CHANGELOG.md b/CHANGELOG.md
index 0cfd7def70..1c8540bebd 100644
--- a/CHANGELOG.md
+++ b/CHANGELOG.md
@@ -24,6 +24,8 @@ and this project adheres to [Semantic Versioning](https://semver.org/spec/v2.0.0
   ([#538](https://github.com/open-telemetry/opentelemetry-python-contrib/pull/538))
 - Changed the psycopg2-binary to psycopg2 as dependency in production
   ([#543](https://github.com/open-telemetry/opentelemetry-python-contrib/pull/543))
+- Implement consistent way of checking if instrumentation is already active
+  ([#549](https://github.com/open-telemetry/opentelemetry-python-contrib/pull/549))
 - Require aiopg to be less than 1.3.0
   ([#560](https://github.com/open-telemetry/opentelemetry-python-contrib/pull/560))
 - `opentelemetry-instrumentation-django` Migrated Django middleware to new-style.
diff --git a/instrumentation/opentelemetry-instrumentation-aiohttp-client/src/opentelemetry/instrumentation/aiohttp_client/__init__.py b/instrumentation/opentelemetry-instrumentation-aiohttp-client/src/opentelemetry/instrumentation/aiohttp_client/__init__.py
index d4000584bb..c32efab5a5 100644
--- a/instrumentation/opentelemetry-instrumentation-aiohttp-client/src/opentelemetry/instrumentation/aiohttp_client/__init__.py
+++ b/instrumentation/opentelemetry-instrumentation-aiohttp-client/src/opentelemetry/instrumentation/aiohttp_client/__init__.py
@@ -259,7 +259,7 @@ def instrumented_init(wrapped, instance, args, kwargs):
             span_name=span_name,
             tracer_provider=tracer_provider,
         )
-        trace_config.opentelemetry_aiohttp_instrumented = True
+        trace_config._is_instrumented_by_opentelemetry = True
         trace_configs.append(trace_config)
 
         kwargs["trace_configs"] = trace_configs
@@ -282,7 +282,7 @@ def _uninstrument_session(client_session: aiohttp.ClientSession):
     client_session._trace_configs = [
         trace_config
         for trace_config in trace_configs
-        if not hasattr(trace_config, "opentelemetry_aiohttp_instrumented")
+        if not hasattr(trace_config, "_is_instrumented_by_opentelemetry")
     ]
 
 
diff --git a/instrumentation/opentelemetry-instrumentation-aiopg/src/opentelemetry/instrumentation/aiopg/aiopg_integration.py b/instrumentation/opentelemetry-instrumentation-aiopg/src/opentelemetry/instrumentation/aiopg/aiopg_integration.py
index 86a600499a..d140c18838 100644
--- a/instrumentation/opentelemetry-instrumentation-aiopg/src/opentelemetry/instrumentation/aiopg/aiopg_integration.py
+++ b/instrumentation/opentelemetry-instrumentation-aiopg/src/opentelemetry/instrumentation/aiopg/aiopg_integration.py
@@ -1,10 +1,7 @@
 import typing
 
 import wrapt
-from aiopg.utils import (  # pylint: disable=no-name-in-module
-    _ContextManager,
-    _PoolAcquireContextManager,
-)
+from aiopg.utils import _ContextManager, _PoolAcquireContextManager
 
 from opentelemetry.instrumentation.dbapi import (
     CursorTracer,
@@ -64,9 +61,7 @@ def __init__(self, connection, *args, **kwargs):
 
         def cursor(self, *args, **kwargs):
             coro = self._cursor(*args, **kwargs)
-            return _ContextManager(  # pylint: disable=no-value-for-parameter
-                coro
-            )
+            return _ContextManager(coro)
 
         async def _cursor(self, *args, **kwargs):
             # pylint: disable=protected-access
diff --git a/instrumentation/opentelemetry-instrumentation-aiopg/src/opentelemetry/instrumentation/aiopg/wrappers.py b/instrumentation/opentelemetry-instrumentation-aiopg/src/opentelemetry/instrumentation/aiopg/wrappers.py
index 796792b492..f786772c49 100644
--- a/instrumentation/opentelemetry-instrumentation-aiopg/src/opentelemetry/instrumentation/aiopg/wrappers.py
+++ b/instrumentation/opentelemetry-instrumentation-aiopg/src/opentelemetry/instrumentation/aiopg/wrappers.py
@@ -41,6 +41,7 @@
 
 from opentelemetry.instrumentation.aiopg.aiopg_integration import (
     AiopgIntegration,
+    AsyncProxyObject,
     get_traced_connection_proxy,
 )
 from opentelemetry.instrumentation.aiopg.version import __version__
@@ -153,6 +154,10 @@ def instrument_connection(
     Returns:
         An instrumented connection.
     """
+    if isinstance(connection, AsyncProxyObject):
+        logger.warning("Connection already instrumented")
+        return connection
+
     db_integration = AiopgIntegration(
         name,
         database_system,
@@ -173,7 +178,7 @@ def uninstrument_connection(connection):
     Returns:
         An uninstrumented connection.
     """
-    if isinstance(connection, wrapt.ObjectProxy):
+    if isinstance(connection, AsyncProxyObject):
         return connection.__wrapped__
 
     logger.warning("Connection is not instrumented")
diff --git a/instrumentation/opentelemetry-instrumentation-aiopg/tests/test_aiopg_integration.py b/instrumentation/opentelemetry-instrumentation-aiopg/tests/test_aiopg_integration.py
index 48538ad063..24d2299166 100644
--- a/instrumentation/opentelemetry-instrumentation-aiopg/tests/test_aiopg_integration.py
+++ b/instrumentation/opentelemetry-instrumentation-aiopg/tests/test_aiopg_integration.py
@@ -207,6 +207,23 @@ def test_instrument_connection(self):
         spans_list = self.memory_exporter.get_finished_spans()
         self.assertEqual(len(spans_list), 1)
 
+    def test_instrument_connection_after_instrument(self):
+        cnx = async_call(aiopg.connect(database="test"))
+        query = "SELECT * FROM test"
+        cursor = async_call(cnx.cursor())
+        async_call(cursor.execute(query))
+
+        spans_list = self.memory_exporter.get_finished_spans()
+        self.assertEqual(len(spans_list), 0)
+
+        AiopgInstrumentor().instrument()
+        cnx = AiopgInstrumentor().instrument_connection(cnx)
+        cursor = async_call(cnx.cursor())
+        async_call(cursor.execute(query))
+
+        spans_list = self.memory_exporter.get_finished_spans()
+        self.assertEqual(len(spans_list), 1)
+
     def test_custom_tracer_provider_instrument_connection(self):
         resource = resources.Resource.create(
             {"service.name": "db-test-service"}
diff --git a/instrumentation/opentelemetry-instrumentation-dbapi/src/opentelemetry/instrumentation/dbapi/__init__.py b/instrumentation/opentelemetry-instrumentation-dbapi/src/opentelemetry/instrumentation/dbapi/__init__.py
index 2f03d196b5..b7ce6d13b6 100644
--- a/instrumentation/opentelemetry-instrumentation-dbapi/src/opentelemetry/instrumentation/dbapi/__init__.py
+++ b/instrumentation/opentelemetry-instrumentation-dbapi/src/opentelemetry/instrumentation/dbapi/__init__.py
@@ -180,6 +180,10 @@ def instrument_connection(
     Returns:
         An instrumented connection.
     """
+    if isinstance(connection, wrapt.ObjectProxy):
+        logger.warning("Connection already instrumented")
+        return connection
+
     db_integration = DatabaseApiIntegration(
         name,
         database_system,
diff --git a/instrumentation/opentelemetry-instrumentation-fastapi/src/opentelemetry/instrumentation/fastapi/__init__.py b/instrumentation/opentelemetry-instrumentation-fastapi/src/opentelemetry/instrumentation/fastapi/__init__.py
index 933b027018..7847eccb20 100644
--- a/instrumentation/opentelemetry-instrumentation-fastapi/src/opentelemetry/instrumentation/fastapi/__init__.py
+++ b/instrumentation/opentelemetry-instrumentation-fastapi/src/opentelemetry/instrumentation/fastapi/__init__.py
@@ -12,9 +12,11 @@
 # See the License for the specific language governing permissions and
 # limitations under the License.
 
+import logging
 from typing import Collection
 
 import fastapi
+from starlette import middleware
 from starlette.routing import Match
 
 from opentelemetry.instrumentation.asgi import OpenTelemetryMiddleware
@@ -24,6 +26,7 @@
 from opentelemetry.util.http import get_excluded_urls, parse_excluded_urls
 
 _excluded_urls_from_env = get_excluded_urls("FASTAPI")
+_logger = logging.getLogger(__name__)
 
 
 class FastAPIInstrumentor(BaseInstrumentor):
@@ -39,7 +42,10 @@ def instrument_app(
         app: fastapi.FastAPI, tracer_provider=None, excluded_urls=None,
     ):
         """Instrument an uninstrumented FastAPI application."""
-        if not getattr(app, "is_instrumented_by_opentelemetry", False):
+        if not hasattr(app, "_is_instrumented_by_opentelemetry"):
+            app._is_instrumented_by_opentelemetry = False
+
+        if not getattr(app, "_is_instrumented_by_opentelemetry", False):
             if excluded_urls is None:
                 excluded_urls = _excluded_urls_from_env
             else:
@@ -51,7 +57,21 @@ def instrument_app(
                 span_details_callback=_get_route_details,
                 tracer_provider=tracer_provider,
             )
-            app.is_instrumented_by_opentelemetry = True
+            app._is_instrumented_by_opentelemetry = True
+        else:
+            _logger.warning(
+                "Attempting to instrument FastAPI app while already instrumented"
+            )
+
+    @staticmethod
+    def uninstrument_app(app: fastapi.FastAPI):
+        app.user_middleware = [
+            x
+            for x in app.user_middleware
+            if x.cls is not OpenTelemetryMiddleware
+        ]
+        app.middleware_stack = app.build_middleware_stack()
+        app._is_instrumented_by_opentelemetry = False
 
     def instrumentation_dependencies(self) -> Collection[str]:
         return _instruments
diff --git a/instrumentation/opentelemetry-instrumentation-fastapi/tests/test_fastapi_instrumentation.py b/instrumentation/opentelemetry-instrumentation-fastapi/tests/test_fastapi_instrumentation.py
index e3e6f8f4c5..6d0f16f19b 100644
--- a/instrumentation/opentelemetry-instrumentation-fastapi/tests/test_fastapi_instrumentation.py
+++ b/instrumentation/opentelemetry-instrumentation-fastapi/tests/test_fastapi_instrumentation.py
@@ -19,6 +19,7 @@
 from fastapi.testclient import TestClient
 
 import opentelemetry.instrumentation.fastapi as otel_fastapi
+from opentelemetry.instrumentation.asgi import OpenTelemetryMiddleware
 from opentelemetry.sdk.resources import Resource
 from opentelemetry.semconv.trace import SpanAttributes
 from opentelemetry.test.test_base import TestBase
@@ -57,6 +58,47 @@ def tearDown(self):
         super().tearDown()
         self.env_patch.stop()
         self.exclude_patch.stop()
+        with self.disable_logging():
+            self._instrumentor.uninstrument()
+            self._instrumentor.uninstrument_app(self._app)
+
+    def test_instrument_app_with_instrument(self):
+        if not isinstance(self, TestAutoInstrumentation):
+            self._instrumentor.instrument()
+        self._client.get("/foobar")
+        spans = self.memory_exporter.get_finished_spans()
+        self.assertEqual(len(spans), 3)
+        for span in spans:
+            self.assertIn("/foobar", span.name)
+
+    def test_uninstrument_app(self):
+        self._client.get("/foobar")
+        spans = self.memory_exporter.get_finished_spans()
+        self.assertEqual(len(spans), 3)
+        # pylint: disable=import-outside-toplevel
+        from fastapi.middleware.httpsredirect import HTTPSRedirectMiddleware
+
+        self._app.add_middleware(HTTPSRedirectMiddleware)
+        self._instrumentor.uninstrument_app(self._app)
+        print(self._app.user_middleware[0].cls)
+        self.assertFalse(
+            isinstance(
+                self._app.user_middleware[0].cls, OpenTelemetryMiddleware
+            )
+        )
+        self._client = TestClient(self._app)
+        resp = self._client.get("/foobar")
+        self.assertEqual(200, resp.status_code)
+        span_list = self.memory_exporter.get_finished_spans()
+        self.assertEqual(len(span_list), 3)
+
+    def test_uninstrument_app_after_instrument(self):
+        if not isinstance(self, TestAutoInstrumentation):
+            self._instrumentor.instrument()
+        self._instrumentor.uninstrument_app(self._app)
+        self._client.get("/foobar")
+        spans = self.memory_exporter.get_finished_spans()
+        self.assertEqual(len(spans), 0)
 
     def test_basic_fastapi_call(self):
         self._client.get("/foobar")
diff --git a/instrumentation/opentelemetry-instrumentation-flask/src/opentelemetry/instrumentation/flask/__init__.py b/instrumentation/opentelemetry-instrumentation-flask/src/opentelemetry/instrumentation/flask/__init__.py
index f37859ac30..c27207d196 100644
--- a/instrumentation/opentelemetry-instrumentation-flask/src/opentelemetry/instrumentation/flask/__init__.py
+++ b/instrumentation/opentelemetry-instrumentation-flask/src/opentelemetry/instrumentation/flask/__init__.py
@@ -193,7 +193,8 @@ class _InstrumentedFlask(flask.Flask):
     def __init__(self, *args, **kwargs):
         super().__init__(*args, **kwargs)
 
-        self._original_wsgi_ = self.wsgi_app
+        self._original_wsgi_app = self.wsgi_app
+        self._is_instrumented_by_opentelemetry = True
 
         self.wsgi_app = _rewrapped_app(
             self.wsgi_app, _InstrumentedFlask._response_hook
@@ -229,18 +230,21 @@ def _instrument(self, **kwargs):
             _InstrumentedFlask._request_hook = request_hook
         if callable(response_hook):
             _InstrumentedFlask._response_hook = response_hook
-        flask.Flask = _InstrumentedFlask
         tracer_provider = kwargs.get("tracer_provider")
         _InstrumentedFlask._tracer_provider = tracer_provider
         flask.Flask = _InstrumentedFlask
 
+    def _uninstrument(self, **kwargs):
+        flask.Flask = self._original_flask
+
+    @staticmethod
     def instrument_app(
-        self, app, request_hook=None, response_hook=None, tracer_provider=None
-    ):  # pylint: disable=no-self-use
-        if not hasattr(app, "_is_instrumented"):
-            app._is_instrumented = False
+        app, request_hook=None, response_hook=None, tracer_provider=None
+    ):
+        if not hasattr(app, "_is_instrumented_by_opentelemetry"):
+            app._is_instrumented_by_opentelemetry = False
 
-        if not app._is_instrumented:
+        if not app._is_instrumented_by_opentelemetry:
             app._original_wsgi_app = app.wsgi_app
             app.wsgi_app = _rewrapped_app(app.wsgi_app, response_hook)
 
@@ -250,28 +254,22 @@ def instrument_app(
             app._before_request = _before_request
             app.before_request(_before_request)
             app.teardown_request(_teardown_request)
-            app._is_instrumented = True
+            app._is_instrumented_by_opentelemetry = True
         else:
             _logger.warning(
                 "Attempting to instrument Flask app while already instrumented"
             )
 
-    def _uninstrument(self, **kwargs):
-        flask.Flask = self._original_flask
-
-    def uninstrument_app(self, app):  # pylint: disable=no-self-use
-        if not hasattr(app, "_is_instrumented"):
-            app._is_instrumented = False
-
-        if app._is_instrumented:
+    @staticmethod
+    def uninstrument_app(app):
+        if hasattr(app, "_original_wsgi_app"):
             app.wsgi_app = app._original_wsgi_app
 
             # FIXME add support for other Flask blueprints that are not None
             app.before_request_funcs[None].remove(app._before_request)
             app.teardown_request_funcs[None].remove(_teardown_request)
             del app._original_wsgi_app
-
-            app._is_instrumented = False
+            app._is_instrumented_by_opentelemetry = False
         else:
             _logger.warning(
                 "Attempting to uninstrument Flask "
diff --git a/instrumentation/opentelemetry-instrumentation-flask/tests/test_programmatic.py b/instrumentation/opentelemetry-instrumentation-flask/tests/test_programmatic.py
index 8eb916b3d0..4e3e313945 100644
--- a/instrumentation/opentelemetry-instrumentation-flask/tests/test_programmatic.py
+++ b/instrumentation/opentelemetry-instrumentation-flask/tests/test_programmatic.py
@@ -79,7 +79,16 @@ def tearDown(self):
         with self.disable_logging():
             FlaskInstrumentor().uninstrument_app(self.app)
 
-    def test_uninstrument(self):
+    def test_instrument_app_and_instrument(self):
+        FlaskInstrumentor().instrument()
+        resp = self.client.get("/hello/123")
+        self.assertEqual(200, resp.status_code)
+        self.assertEqual([b"Hello: 123"], list(resp.response))
+        span_list = self.memory_exporter.get_finished_spans()
+        self.assertEqual(len(span_list), 1)
+        FlaskInstrumentor().uninstrument()
+
+    def test_uninstrument_app(self):
         resp = self.client.get("/hello/123")
         self.assertEqual(200, resp.status_code)
         self.assertEqual([b"Hello: 123"], list(resp.response))
@@ -94,6 +103,16 @@ def test_uninstrument(self):
         span_list = self.memory_exporter.get_finished_spans()
         self.assertEqual(len(span_list), 1)
 
+    def test_uninstrument_app_after_instrument(self):
+        FlaskInstrumentor().instrument()
+        FlaskInstrumentor().uninstrument_app(self.app)
+        resp = self.client.get("/hello/123")
+        self.assertEqual(200, resp.status_code)
+        self.assertEqual([b"Hello: 123"], list(resp.response))
+        span_list = self.memory_exporter.get_finished_spans()
+        self.assertEqual(len(span_list), 0)
+        FlaskInstrumentor().uninstrument()
+
     # pylint: disable=no-member
     def test_only_strings_in_environ(self):
         """
diff --git a/instrumentation/opentelemetry-instrumentation-psycopg2/src/opentelemetry/instrumentation/psycopg2/__init__.py b/instrumentation/opentelemetry-instrumentation-psycopg2/src/opentelemetry/instrumentation/psycopg2/__init__.py
index 675d9ec258..4285fec1d0 100644
--- a/instrumentation/opentelemetry-instrumentation-psycopg2/src/opentelemetry/instrumentation/psycopg2/__init__.py
+++ b/instrumentation/opentelemetry-instrumentation-psycopg2/src/opentelemetry/instrumentation/psycopg2/__init__.py
@@ -39,6 +39,7 @@
 ---
 """
 
+import logging
 import typing
 from typing import Collection
 
@@ -53,6 +54,7 @@
 from opentelemetry.instrumentation.psycopg2.package import _instruments
 from opentelemetry.instrumentation.psycopg2.version import __version__
 
+_logger = logging.getLogger(__name__)
 _OTEL_CURSOR_FACTORY_KEY = "_otel_orig_cursor_factory"
 
 
@@ -91,24 +93,32 @@ def _uninstrument(self, **kwargs):
         dbapi.unwrap_connect(psycopg2, "connect")
 
     # TODO(owais): check if core dbapi can do this for all dbapi implementations e.g, pymysql and mysql
-    def instrument_connection(
-        self, connection, tracer_provider=None
-    ):  # pylint: disable=no-self-use
-        setattr(
-            connection, _OTEL_CURSOR_FACTORY_KEY, connection.cursor_factory
-        )
-        connection.cursor_factory = _new_cursor_factory(
-            tracer_provider=tracer_provider
-        )
+    @staticmethod
+    def instrument_connection(connection, tracer_provider=None):
+        if not hasattr(connection, "_is_instrumented_by_opentelemetry"):
+            connection._is_instrumented_by_opentelemetry = False
+
+        if not connection._is_instrumented_by_opentelemetry:
+            setattr(
+                connection, _OTEL_CURSOR_FACTORY_KEY, connection.cursor_factory
+            )
+            connection.cursor_factory = _new_cursor_factory(
+                tracer_provider=tracer_provider
+            )
+            connection._is_instrumented_by_opentelemetry = True
+        else:
+            _logger.warning(
+                "Attempting to instrument Psycopg connection while already instrumented"
+            )
         return connection
 
     # TODO(owais): check if core dbapi can do this for all dbapi implementations e.g, pymysql and mysql
-    def uninstrument_connection(
-        self, connection
-    ):  # pylint: disable=no-self-use
+    @staticmethod
+    def uninstrument_connection(connection):
         connection.cursor_factory = getattr(
             connection, _OTEL_CURSOR_FACTORY_KEY, None
         )
+
         return connection
 
 
diff --git a/instrumentation/opentelemetry-instrumentation-psycopg2/tests/test_psycopg2_integration.py b/instrumentation/opentelemetry-instrumentation-psycopg2/tests/test_psycopg2_integration.py
index fa8172ba15..8219e2a6b5 100644
--- a/instrumentation/opentelemetry-instrumentation-psycopg2/tests/test_psycopg2_integration.py
+++ b/instrumentation/opentelemetry-instrumentation-psycopg2/tests/test_psycopg2_integration.py
@@ -172,7 +172,25 @@ def test_instrument_connection(self):
         self.assertEqual(len(spans_list), 1)
 
     # pylint: disable=unused-argument
-    def test_uninstrument_connection(self):
+    def test_instrument_connection_with_instrument(self):
+        cnx = psycopg2.connect(database="test")
+        query = "SELECT * FROM test"
+        cursor = cnx.cursor()
+        cursor.execute(query)
+
+        spans_list = self.memory_exporter.get_finished_spans()
+        self.assertEqual(len(spans_list), 0)
+
+        Psycopg2Instrumentor().instrument()
+        cnx = Psycopg2Instrumentor().instrument_connection(cnx)
+        cursor = cnx.cursor()
+        cursor.execute(query)
+
+        spans_list = self.memory_exporter.get_finished_spans()
+        self.assertEqual(len(spans_list), 1)
+
+    # pylint: disable=unused-argument
+    def test_uninstrument_connection_with_instrument(self):
         Psycopg2Instrumentor().instrument()
         cnx = psycopg2.connect(database="test")
         query = "SELECT * FROM test"
@@ -188,3 +206,21 @@ def test_uninstrument_connection(self):
 
         spans_list = self.memory_exporter.get_finished_spans()
         self.assertEqual(len(spans_list), 1)
+
+    # pylint: disable=unused-argument
+    def test_uninstrument_connection_with_instrument_connection(self):
+        cnx = psycopg2.connect(database="test")
+        Psycopg2Instrumentor().instrument_connection(cnx)
+        query = "SELECT * FROM test"
+        cursor = cnx.cursor()
+        cursor.execute(query)
+
+        spans_list = self.memory_exporter.get_finished_spans()
+        self.assertEqual(len(spans_list), 1)
+
+        cnx = Psycopg2Instrumentor().uninstrument_connection(cnx)
+        cursor = cnx.cursor()
+        cursor.execute(query)
+
+        spans_list = self.memory_exporter.get_finished_spans()
+        self.assertEqual(len(spans_list), 1)
diff --git a/instrumentation/opentelemetry-instrumentation-pymysql/src/opentelemetry/instrumentation/pymysql/__init__.py b/instrumentation/opentelemetry-instrumentation-pymysql/src/opentelemetry/instrumentation/pymysql/__init__.py
index e70d4354f3..0b524ec7f6 100644
--- a/instrumentation/opentelemetry-instrumentation-pymysql/src/opentelemetry/instrumentation/pymysql/__init__.py
+++ b/instrumentation/opentelemetry-instrumentation-pymysql/src/opentelemetry/instrumentation/pymysql/__init__.py
@@ -49,17 +49,16 @@
 from opentelemetry.instrumentation.pymysql.package import _instruments
 from opentelemetry.instrumentation.pymysql.version import __version__
 
+_CONNECTION_ATTRIBUTES = {
+    "database": "db",
+    "port": "port",
+    "host": "host",
+    "user": "user",
+}
+_DATABASE_SYSTEM = "mysql"
 
-class PyMySQLInstrumentor(BaseInstrumentor):
-    _CONNECTION_ATTRIBUTES = {
-        "database": "db",
-        "port": "port",
-        "host": "host",
-        "user": "user",
-    }
-
-    _DATABASE_SYSTEM = "mysql"
 
+class PyMySQLInstrumentor(BaseInstrumentor):
     def instrumentation_dependencies(self) -> Collection[str]:
         return _instruments
 
@@ -73,8 +72,8 @@ def _instrument(self, **kwargs):
             __name__,
             pymysql,
             "connect",
-            self._DATABASE_SYSTEM,
-            self._CONNECTION_ATTRIBUTES,
+            _DATABASE_SYSTEM,
+            _CONNECTION_ATTRIBUTES,
             version=__version__,
             tracer_provider=tracer_provider,
         )
@@ -83,8 +82,8 @@ def _uninstrument(self, **kwargs):
         """"Disable PyMySQL instrumentation"""
         dbapi.unwrap_connect(pymysql, "connect")
 
-    # pylint:disable=no-self-use
-    def instrument_connection(self, connection, tracer_provider=None):
+    @staticmethod
+    def instrument_connection(connection, tracer_provider=None):
         """Enable instrumentation in a PyMySQL connection.
 
         Args:
@@ -99,13 +98,14 @@ def instrument_connection(self, connection, tracer_provider=None):
         return dbapi.instrument_connection(
             __name__,
             connection,
-            self._DATABASE_SYSTEM,
-            self._CONNECTION_ATTRIBUTES,
+            _DATABASE_SYSTEM,
+            _CONNECTION_ATTRIBUTES,
             version=__version__,
             tracer_provider=tracer_provider,
         )
 
-    def uninstrument_connection(self, connection):
+    @staticmethod
+    def uninstrument_connection(connection):
         """Disable instrumentation in a PyMySQL connection.
 
         Args:
diff --git a/instrumentation/opentelemetry-instrumentation-pyramid/src/opentelemetry/instrumentation/pyramid/__init__.py b/instrumentation/opentelemetry-instrumentation-pyramid/src/opentelemetry/instrumentation/pyramid/__init__.py
index dc8ed6e7a9..401b6bb3cf 100644
--- a/instrumentation/opentelemetry-instrumentation-pyramid/src/opentelemetry/instrumentation/pyramid/__init__.py
+++ b/instrumentation/opentelemetry-instrumentation-pyramid/src/opentelemetry/instrumentation/pyramid/__init__.py
@@ -140,8 +140,8 @@ def _uninstrument(self, **kwargs):
         """"Disable Pyramid instrumentation"""
         unwrap(Configurator, "__init__")
 
-    # pylint:disable=no-self-use
-    def instrument_config(self, config):
+    @staticmethod
+    def instrument_config(config):
         """Enable instrumentation in a Pyramid configurator.
 
         Args:
@@ -149,5 +149,6 @@ def instrument_config(self, config):
         """
         config.include("opentelemetry.instrumentation.pyramid.callbacks")
 
-    def uninstrument_config(self, config):
+    @staticmethod
+    def uninstrument_config(config):
         config.add_settings({SETTING_TRACE_ENABLED: False})
diff --git a/instrumentation/opentelemetry-instrumentation-sqlite3/src/opentelemetry/instrumentation/sqlite3/__init__.py b/instrumentation/opentelemetry-instrumentation-sqlite3/src/opentelemetry/instrumentation/sqlite3/__init__.py
index f8cd6e88cc..a0842214e5 100644
--- a/instrumentation/opentelemetry-instrumentation-sqlite3/src/opentelemetry/instrumentation/sqlite3/__init__.py
+++ b/instrumentation/opentelemetry-instrumentation-sqlite3/src/opentelemetry/instrumentation/sqlite3/__init__.py
@@ -48,13 +48,13 @@
 from opentelemetry.instrumentation.sqlite3.version import __version__
 from opentelemetry.trace import get_tracer
 
+# No useful attributes of sqlite3 connection object
+_CONNECTION_ATTRIBUTES = {}
 
-class SQLite3Instrumentor(BaseInstrumentor):
-    # No useful attributes of sqlite3 connection object
-    _CONNECTION_ATTRIBUTES = {}
+_DATABASE_SYSTEM = "sqlite"
 
-    _DATABASE_SYSTEM = "sqlite"
 
+class SQLite3Instrumentor(BaseInstrumentor):
     def instrumentation_dependencies(self) -> Collection[str]:
         return _instruments
 
@@ -68,8 +68,8 @@ def _instrument(self, **kwargs):
             __name__,
             sqlite3,
             "connect",
-            self._DATABASE_SYSTEM,
-            self._CONNECTION_ATTRIBUTES,
+            _DATABASE_SYSTEM,
+            _CONNECTION_ATTRIBUTES,
             version=__version__,
             tracer_provider=tracer_provider,
         )
@@ -78,8 +78,8 @@ def _uninstrument(self, **kwargs):
         """"Disable SQLite3 instrumentation"""
         dbapi.unwrap_connect(sqlite3, "connect")
 
-    # pylint:disable=no-self-use
-    def instrument_connection(self, connection, tracer_provider=None):
+    @staticmethod
+    def instrument_connection(connection, tracer_provider=None):
         """Enable instrumentation in a SQLite connection.
 
         Args:
@@ -94,13 +94,14 @@ def instrument_connection(self, connection, tracer_provider=None):
         return dbapi.instrument_connection(
             __name__,
             connection,
-            self._DATABASE_SYSTEM,
-            self._CONNECTION_ATTRIBUTES,
+            _DATABASE_SYSTEM,
+            _CONNECTION_ATTRIBUTES,
             version=__version__,
             tracer_provider=tracer_provider,
         )
 
-    def uninstrument_connection(self, connection):
+    @staticmethod
+    def uninstrument_connection(connection):
         """Disable instrumentation in a SQLite connection.
 
         Args:
diff --git a/opentelemetry-instrumentation/src/opentelemetry/instrumentation/instrumentor.py b/opentelemetry-instrumentation/src/opentelemetry/instrumentation/instrumentor.py
index 43a4ea59bb..74ebe86746 100644
--- a/opentelemetry-instrumentation/src/opentelemetry/instrumentation/instrumentor.py
+++ b/opentelemetry-instrumentation/src/opentelemetry/instrumentation/instrumentor.py
@@ -43,7 +43,7 @@ class BaseInstrumentor(ABC):
     """
 
     _instance = None
-    _is_instrumented = False
+    _is_instrumented_by_opentelemetry = False
 
     def __new__(cls, *args, **kwargs):
 
@@ -52,6 +52,10 @@ def __new__(cls, *args, **kwargs):
 
         return cls._instance
 
+    @property
+    def is_instrumented_by_opentelemetry(self):
+        return self._is_instrumented_by_opentelemetry
+
     @abstractmethod
     def instrumentation_dependencies(self) -> Collection[str]:
         """Return a list of python packages with versions that the will be instrumented.
@@ -90,7 +94,7 @@ def instrument(self, **kwargs):
         ``opentelemetry-instrument`` command does.
         """
 
-        if self._is_instrumented:
+        if self._is_instrumented_by_opentelemetry:
             _LOG.warning("Attempting to instrument while already instrumented")
             return None
 
@@ -99,13 +103,13 @@ def instrument(self, **kwargs):
         if not skip_dep_check:
             conflict = self._check_dependency_conflicts()
             if conflict:
-                _LOG.warning(conflict)
+                _LOG.error(conflict)
                 return None
 
         result = self._instrument(  # pylint: disable=assignment-from-no-return
             **kwargs
         )
-        self._is_instrumented = True
+        self._is_instrumented_by_opentelemetry = True
         return result
 
     def uninstrument(self, **kwargs):
@@ -115,9 +119,9 @@ def uninstrument(self, **kwargs):
         usage of ``kwargs``.
         """
 
-        if self._is_instrumented:
+        if self._is_instrumented_by_opentelemetry:
             result = self._uninstrument(**kwargs)
-            self._is_instrumented = False
+            self._is_instrumented_by_opentelemetry = False
             return result
 
         _LOG.warning("Attempting to uninstrument while already uninstrumented")
diff --git a/opentelemetry-instrumentation/tests/test_distro.py b/opentelemetry-instrumentation/tests/test_distro.py
index 2346d5709f..399b3f8a65 100644
--- a/opentelemetry-instrumentation/tests/test_distro.py
+++ b/opentelemetry-instrumentation/tests/test_distro.py
@@ -53,6 +53,6 @@ def test_load_instrumentor(self):
         instrumentor = MockInstrumetor()
         entry_point = MockEntryPoint(MockInstrumetor)
 
-        self.assertFalse(instrumentor._is_instrumented)
+        self.assertFalse(instrumentor._is_instrumented_by_opentelemetry)
         distro.load_instrumentor(entry_point)
-        self.assertTrue(instrumentor._is_instrumented)
+        self.assertTrue(instrumentor._is_instrumented_by_opentelemetry)