diff --git a/instrumentation/opentelemetry-instrumentation-celery/setup.cfg b/instrumentation/opentelemetry-instrumentation-celery/setup.cfg
index 691e6035cd..b12587fd7e 100644
--- a/instrumentation/opentelemetry-instrumentation-celery/setup.cfg
+++ b/instrumentation/opentelemetry-instrumentation-celery/setup.cfg
@@ -39,14 +39,14 @@ package_dir=
     =src
 packages=find_namespace:
 install_requires =
+    celery >= 4.0, < 6.0
     opentelemetry-api == 0.17.dev0
     opentelemetry-instrumentation == 0.17.dev0
-    celery ~= 4.0
 
 [options.extras_require]
 test =
     pytest
-    celery ~= 4.0
+    celery >= 4.0, < 6.0
     opentelemetry-test == 0.17.dev0
 
 [options.packages.find]
diff --git a/tox.ini b/tox.ini
index 6ceb4a8c2c..509d707825 100644
--- a/tox.ini
+++ b/tox.ini
@@ -349,7 +349,7 @@ deps =
   aiopg >= 0.13.0
   sqlalchemy ~= 1.3.16
   redis ~= 3.3.11
-  celery ~= 4.0, != 4.4.4
+  celery >= 4.0, < 6.0
   protobuf>=3.13.0
   requests==2.25.0
 changedir =