diff --git a/experimental/CHANGELOG.md b/experimental/CHANGELOG.md
index 65d1819485c..0f6a5af5c37 100644
--- a/experimental/CHANGELOG.md
+++ b/experimental/CHANGELOG.md
@@ -31,6 +31,8 @@ All notable changes to experimental packages in this project will be documented
 
 ### :bug: (Bug Fix)
 
+* fix: require import-in-the-middle in order to fix an issue with bundlers [#4546](https://github.com/open-telemetry/opentelemetry-js/pull/4546) @dyladan
+
 ### :books: (Refine Doc)
 
 * docs(instrumentation): better docs for supportedVersions option [#4693](https://github.com/open-telemetry/opentelemetry-js/pull/4693) @blumamir
diff --git a/experimental/packages/opentelemetry-instrumentation/src/platform/node/instrumentation.ts b/experimental/packages/opentelemetry-instrumentation/src/platform/node/instrumentation.ts
index 6c2aa08281e..f7932a79a06 100644
--- a/experimental/packages/opentelemetry-instrumentation/src/platform/node/instrumentation.ts
+++ b/experimental/packages/opentelemetry-instrumentation/src/platform/node/instrumentation.ts
@@ -25,7 +25,8 @@ import {
   Hooked,
 } from './RequireInTheMiddleSingleton';
 import type { HookFn } from 'import-in-the-middle';
-import * as ImportInTheMiddle from 'import-in-the-middle';
+// eslint-disable-next-line @typescript-eslint/no-var-requires
+const ImportInTheMiddle = require('import-in-the-middle');
 import {
   InstrumentationConfig,
   InstrumentationModuleDefinition,
@@ -309,12 +310,11 @@ export abstract class InstrumentationBase<
         : this._requireInTheMiddleSingleton.register(module.name, onRequire);
 
       this._hooks.push(hook);
-      const esmHook =
-        new (ImportInTheMiddle as unknown as typeof ImportInTheMiddle.default)(
-          [module.name],
-          { internals: false },
-          <HookFn>hookFn
-        );
+      const esmHook = new ImportInTheMiddle(
+        [module.name],
+        { internals: false },
+        <HookFn>hookFn
+      );
       this._hooks.push(esmHook);
     }
   }