diff --git a/instrumentation/jdbc/library/src/main/java/io/opentelemetry/instrumentation/jdbc/internal/JdbcConnectionUrlParser.java b/instrumentation/jdbc/library/src/main/java/io/opentelemetry/instrumentation/jdbc/internal/JdbcConnectionUrlParser.java
index cef0dc129667..e6074012ff91 100644
--- a/instrumentation/jdbc/library/src/main/java/io/opentelemetry/instrumentation/jdbc/internal/JdbcConnectionUrlParser.java
+++ b/instrumentation/jdbc/library/src/main/java/io/opentelemetry/instrumentation/jdbc/internal/JdbcConnectionUrlParser.java
@@ -863,11 +863,15 @@ public static DbInfo parse(String connectionUrl, Properties props) {
     // Make this easier and ignore case.
     connectionUrl = connectionUrl.toLowerCase(Locale.ROOT);
 
-    if (!connectionUrl.startsWith("jdbc:")) {
+    String jdbcUrl;
+    if (connectionUrl.startsWith("jdbc:")) {
+      jdbcUrl = connectionUrl.substring("jdbc:".length());
+    } else if (connectionUrl.startsWith("jdbc-secretsmanager:")) {
+      jdbcUrl = connectionUrl.substring("jdbc-secretsmanager:".length());
+    } else {
       return DEFAULT;
     }
 
-    String jdbcUrl = connectionUrl.substring("jdbc:".length());
     int typeLoc = jdbcUrl.indexOf(':');
 
     if (typeLoc < 1) {
diff --git a/instrumentation/jdbc/library/src/test/groovy/io/opentelemetry/instrumentation/jdbc/internal/JdbcConnectionUrlParserTest.groovy b/instrumentation/jdbc/library/src/test/groovy/io/opentelemetry/instrumentation/jdbc/internal/JdbcConnectionUrlParserTest.groovy
index b4048831e7cc..e6cba306684b 100644
--- a/instrumentation/jdbc/library/src/test/groovy/io/opentelemetry/instrumentation/jdbc/internal/JdbcConnectionUrlParserTest.groovy
+++ b/instrumentation/jdbc/library/src/test/groovy/io/opentelemetry/instrumentation/jdbc/internal/JdbcConnectionUrlParserTest.groovy
@@ -219,6 +219,12 @@ class JdbcConnectionUrlParserTest extends Specification {
     "jdbc:tibcosoftware:postgresql://server_name:5432;DatabaseName=dbname"                            | null     | "tibcosoftware:postgresql://server_name:5432"                      | "postgresql" | "postgresql"  | null          | "server_name"                               | 5432  | null                               | "dbname"
     "jdbc:tibcosoftware:db2://server_name:50000;DatabaseName=dbname"                                  | null     | "tibcosoftware:db2://server_name:50000"                            | "db2"        | "db2"         | null          | "server_name"                               | 50000 | null                               | "dbname"
 
+    // https://docs.aws.amazon.com/secretsmanager/latest/userguide/retrieving-secrets_jdbc.html
+    "jdbc-secretsmanager:mysql://example.com:50000"                                                   | null     | "mysql://example.com:50000"                                        | "mysql"      | null          | null          | "example.com"                               | 50000 | null                               | null
+    "jdbc-secretsmanager:postgresql://example.com:50000/dbname"                                       | null     | "postgresql://example.com:50000"                                   | "postgresql" | null          | null          | "example.com"                               | 50000 | null                               | "dbname"
+    "jdbc-secretsmanager:oracle:thin:@example.com:50000/ORCL"                                         | null     | "oracle:thin://example.com:50000"                                  | "oracle"     | "thin"        | null          | "example.com"                               | 50000 | "orcl"                             | null
+    "jdbc-secretsmanager:sqlserver://example.com:50000"                                               | null     | "sqlserver://example.com:50000"                                    | "mssql"      | null          | null          | "example.com"                               | 50000 | null                               | null
+
     expected = DbInfo.builder().system(system).subtype(subtype).user(user).name(name).db(db).host(host).port(port).shortUrl(shortUrl).build()
   }
 }