diff --git a/src/main/webapp/app/pages/curation/collapsible/CancerTypeCollapsible.tsx b/src/main/webapp/app/pages/curation/collapsible/CancerTypeCollapsible.tsx
index e7d00b158..4793314b6 100644
--- a/src/main/webapp/app/pages/curation/collapsible/CancerTypeCollapsible.tsx
+++ b/src/main/webapp/app/pages/curation/collapsible/CancerTypeCollapsible.tsx
@@ -10,7 +10,6 @@ import { isSectionRemovableWithoutReview } from 'app/shared/util/firebase/fireba
 import EditIcon from 'app/shared/icons/EditIcon';
 import ModifyCancerTypeModal from 'app/shared/modal/ModifyCancerTypeModal';
 import { notifyError } from 'app/oncokb-commons/components/util/NotificationUtils';
-import _ from 'lodash';
 import { getLevelDropdownOptions } from 'app/shared/util/firebase/firebase-level-utils';
 import { DIAGNOSTIC_LEVELS_ORDERING, READABLE_FIELD, PROGNOSTIC_LEVELS_ORDERING } from 'app/config/constants/firebase';
 import { RealtimeTextAreaInput } from 'app/shared/firebase/input/RealtimeInputs';
diff --git a/src/main/webapp/app/pages/curation/collapsible/MutationCollapsible.tsx b/src/main/webapp/app/pages/curation/collapsible/MutationCollapsible.tsx
index c329dd3ea..1b91f1547 100644
--- a/src/main/webapp/app/pages/curation/collapsible/MutationCollapsible.tsx
+++ b/src/main/webapp/app/pages/curation/collapsible/MutationCollapsible.tsx
@@ -35,7 +35,7 @@ import { IRootStore } from 'app/stores';
 import { get, onValue, ref } from 'firebase/database';
 import _ from 'lodash';
 import { observer } from 'mobx-react';
-import React, { useCallback, useEffect, useMemo, useState } from 'react';
+import React, { useCallback, useEffect, useMemo, useRef, useState } from 'react';
 import { Button } from 'reactstrap';
 import BadgeGroup from '../BadgeGroup';
 import { DeleteSectionButton } from '../button/DeleteSectionButton';
@@ -49,6 +49,7 @@ import { NestLevelColor, NestLevelMapping, NestLevelType } from './NestLevel';
 import { RemovableCollapsible } from './RemovableCollapsible';
 import { Unsubscribe } from 'firebase/database';
 import { getLocationIdentifier } from 'app/components/geneHistoryTooltip/gene-history-tooltip-utils';
+import { SimpleConfirmModal } from 'app/shared/modal/SimpleConfirmModal';
 
 export interface IMutationCollapsibleProps extends StoreProps {
   mutationPath: string;
@@ -77,15 +78,21 @@ const MutationCollapsible = ({
   annotatedAltsCache,
   genomicIndicators,
   showLastModified,
+  handleFirebaseUpdate,
 }: IMutationCollapsibleProps) => {
   const firebaseMutationsPath = `${getFirebaseGenePath(isGermline, hugoSymbol)}/mutations`;
 
   const [mutationUuid, setMutationUuid] = useState<string>('');
   const [mutationName, setMutationName] = useState<string>('');
   const [mutationNameReview, setMutationNameReview] = useState<Review | null>(null);
+  const [mutationSummary, setMutationSummary] = useState<string>('');
   const [mutationAlterations, setMutationAlterations] = useState<Alteration[] | null>(null);
   const [isRemovableWithoutReview, setIsRemovableWithoutReview] = useState(false);
   const [relatedAnnotationResult, setRelatedAnnotationResult] = useState<AlterationAnnotationStatus[]>([]);
+  const [oncogenicity, setOncogenicity] = useState<string>('');
+  const [showSimpleConfirmModal, setShowSimpleConfirmModal] = useState<boolean>(false);
+  const [simpleConfirmModalBody, setSimpleConfirmModalBody] = useState<string | undefined>(undefined);
+  const [mutationSummaryRef, setMutationSummaryRef] = useState<HTMLElement | null>(null);
 
   useEffect(() => {
     const arr = annotatedAltsCache?.get(hugoSymbol ?? '', [{ name: mutationName, alterations: mutationAlterations }]) ?? [];
@@ -157,6 +164,11 @@ const MutationCollapsible = ({
         setMutationName(snapshot.val());
       }),
     );
+    callbacks.push(
+      onValue(ref(firebaseDb, `${mutationPath}/summary`), snapshot => {
+        setMutationSummary(snapshot.val());
+      }),
+    );
     callbacks.push(
       onValue(ref(firebaseDb, `${mutationPath}/alterations`), snapshot => {
         setMutationAlterations(snapshot.val());
@@ -169,6 +181,11 @@ const MutationCollapsible = ({
         setIsRemovableWithoutReview(isSectionRemovableWithoutReview(review));
       }),
     );
+    callbacks.push(
+      onValue(ref(firebaseDb, `${mutationPath}/mutation_effect/oncogenic`), snapshot => {
+        setOncogenicity(snapshot.val());
+      }),
+    );
 
     onValue(
       ref(firebaseDb, `${mutationPath}/name_uuid`),
@@ -197,6 +214,34 @@ const MutationCollapsible = ({
     [mutationPath, mutationName, parsedHistoryList],
   );
 
+  async function simpleConfirmModalOnConfirm() {
+    await handleFirebaseUpdate?.(mutationPath, { summary: '' });
+    if (mutationSummaryRef) {
+      mutationSummaryRef.click();
+    }
+    setShowSimpleConfirmModal(false);
+    setSimpleConfirmModalBody(undefined);
+  }
+
+  function oncogenicityRadioOnClick(
+    event: React.MouseEvent<HTMLInputElement> | React.MouseEvent<HTMLLabelElement> | React.MouseEvent<HTMLDivElement>,
+  ) {
+    if (mutationSummary && event.target) {
+      let newOncogenicityVal;
+      if (event.target instanceof HTMLInputElement) {
+        newOncogenicityVal = event.target.value;
+      } else if (event.target instanceof HTMLDivElement || event.target instanceof HTMLLabelElement) {
+        newOncogenicityVal = event.target.innerText;
+      }
+      if (newOncogenicityVal === RADIO_OPTION_NONE) {
+        event.preventDefault();
+        setMutationSummaryRef(event.target as HTMLElement);
+        setShowSimpleConfirmModal(true);
+        setSimpleConfirmModalBody(`Mutation summary will be removed after removing oncogenicity.`);
+      }
+    }
+  }
+
   async function handleDeleteMutation(toVus = false) {
     if (!firebaseDb) {
       return;
@@ -308,6 +353,25 @@ const MutationCollapsible = ({
         }
         isPendingDelete={isMutationPendingDelete}
       >
+        <RealtimeTextAreaInput
+          firebasePath={`${mutationPath}/summary`}
+          inputClass={styles.summaryTextarea}
+          label="Mutation Summary (Optional)"
+          labelIcon={
+            <GeneHistoryTooltip
+              historyData={parsedHistoryList}
+              location={`${getMutationName(mutationName, mutationAlterations)}, ${READABLE_FIELD.SUMMARY}`}
+              locationIdentifier={getLocationIdentifier({
+                mutationUuid,
+                fields: [READABLE_FIELD.SUMMARY],
+              })}
+            />
+          }
+          name="mutationSummary"
+          parseRefs
+          disabled={oncogenicity === ''}
+          disabledMessage={'Not curatable: mutation summary is only curatable when oncogenicity is specified.'}
+        />
         <Collapsible
           idPrefix={`${mutationName}-mutation-effect`}
           title="Mutation Effect"
@@ -369,6 +433,10 @@ const MutationCollapsible = ({
                     }
                   </>
                 }
+                /** Radio a bit tricky. Have to use onMouseDown event to cancel the default event.
+                 * The onclick event does not like to be overwritten **/
+                onMouseDown={oncogenicityRadioOnClick}
+                labelOnClick={oncogenicityRadioOnClick}
                 isRadio
                 options={[...ONCOGENICITY_OPTIONS, RADIO_OPTION_NONE].map(label => ({
                   label,
@@ -598,6 +666,12 @@ const MutationCollapsible = ({
           }}
         />
       ) : undefined}
+      <SimpleConfirmModal
+        show={showSimpleConfirmModal}
+        body={simpleConfirmModalBody}
+        onConfirm={simpleConfirmModalOnConfirm}
+        onCancel={() => setShowSimpleConfirmModal(false)}
+      />
     </>
   );
 };
@@ -623,6 +697,7 @@ const mapStoreToProps = ({
   firebaseDb: firebaseAppStore.firebaseDb,
   annotatedAltsCache: curationPageStore.annotatedAltsCache,
   genomicIndicators: firebaseGenomicIndicatorsStore.data,
+  handleFirebaseUpdate: firebaseGeneService.updateObject,
 });
 
 type StoreProps = Partial<ReturnType<typeof mapStoreToProps>>;
diff --git a/src/main/webapp/app/shared/firebase/input/RealtimeBasicInput.tsx b/src/main/webapp/app/shared/firebase/input/RealtimeBasicInput.tsx
index b2d1451cf..b7d619c94 100644
--- a/src/main/webapp/app/shared/firebase/input/RealtimeBasicInput.tsx
+++ b/src/main/webapp/app/shared/firebase/input/RealtimeBasicInput.tsx
@@ -5,7 +5,7 @@ import { IRootStore } from 'app/stores';
 import { default as classNames, default as classnames } from 'classnames';
 import { onValue, ref } from 'firebase/database';
 import { inject } from 'mobx-react';
-import React, { useEffect, useRef, useState } from 'react';
+import React, { MouseEventHandler, useEffect, useRef, useState } from 'react';
 import { FormFeedback, Input, Label, LabelProps } from 'reactstrap';
 import { InputType } from 'reactstrap/types/lib/Input';
 import * as styles from './styles.module.scss';
@@ -51,6 +51,7 @@ export interface IRealtimeBasicInput extends React.InputHTMLAttributes<HTMLInput
   firebasePath: string; // firebase path that component needs to listen to
   type: RealtimeBasicInputType;
   label: string;
+  labelOnClick?: MouseEventHandler<HTMLLabelElement>;
   invalid?: boolean;
   invalidMessage?: string;
   labelClass?: string;
@@ -58,6 +59,7 @@ export interface IRealtimeBasicInput extends React.InputHTMLAttributes<HTMLInput
   inputClass?: string;
   parseRefs?: boolean;
   updateMetaData?: boolean;
+  disabledMessage?: string;
 }
 
 const RealtimeBasicInput: React.FunctionComponent<IRealtimeBasicInput> = (props: IRealtimeBasicInput) => {
@@ -79,6 +81,11 @@ const RealtimeBasicInput: React.FunctionComponent<IRealtimeBasicInput> = (props:
     updateReviewableContent,
     style,
     updateMetaData,
+    placeholder,
+    disabled,
+    disabledMessage,
+    onMouseDown,
+    labelOnClick,
     ...otherProps
   } = props;
 
@@ -139,7 +146,7 @@ const RealtimeBasicInput: React.FunctionComponent<IRealtimeBasicInput> = (props:
   }, [inputValueLoaded]);
 
   const labelComponent = label && (
-    <RealtimeBasicLabel label={label} labelIcon={labelIcon} id={id} labelClass={isCheckType ? 'mb-0' : 'fw-bold'} />
+    <RealtimeBasicLabel label={label} labelIcon={labelIcon} id={id} labelClass={isCheckType ? 'mb-0' : 'fw-bold'} onClick={labelOnClick} />
   );
 
   const inputChangeHandler = (e: React.ChangeEvent<HTMLInputElement>) => {
@@ -169,22 +176,26 @@ const RealtimeBasicInput: React.FunctionComponent<IRealtimeBasicInput> = (props:
     <>
       <Input
         innerRef={inputRef}
-        className={classNames(inputClass, isCheckType && 'ms-1 position-relative', isTextType && styles.editableTextBox)}
+        className={classNames(inputClass, isCheckType && 'ms-1 position-relative', isTextType && !props.disabled && styles.editableTextBox)}
         id={id}
         name={`${id}-${label.toLowerCase()}`}
         autoComplete="off"
         onChange={e => {
           inputChangeHandler(e);
         }}
+        onMouseDown={onMouseDown}
         type={props.type as InputType}
         style={inputStyle}
         value={inputValue}
         invalid={invalid}
         checked={isCheckType && isChecked()}
+        disabled={disabled}
+        placeholder={placeholder ? placeholder : disabled && disabledMessage ? disabledMessage : ''}
         {...otherProps}
       >
         {children}
       </Input>
+      {disabled && disabledMessage && inputValue && <div className={'text-danger'}>{disabledMessage}</div>}
       {invalid && <FormFeedback>{invalidMessage || ''}</FormFeedback>}
     </>
   );
diff --git a/src/main/webapp/app/shared/firebase/input/RealtimeInputs.tsx b/src/main/webapp/app/shared/firebase/input/RealtimeInputs.tsx
index f46550761..a6ff59bae 100644
--- a/src/main/webapp/app/shared/firebase/input/RealtimeInputs.tsx
+++ b/src/main/webapp/app/shared/firebase/input/RealtimeInputs.tsx
@@ -1,4 +1,4 @@
-import React from 'react';
+import React, { MouseEventHandler } from 'react';
 import RealtimeBasicInput, { IRealtimeBasicInput, RealtimeInputType } from './RealtimeBasicInput';
 
 /**
@@ -40,6 +40,9 @@ export interface IRealtimeCheckedInputGroup {
   inlineHeader?: boolean;
   options: RealtimeCheckedInputOption[];
   disabled?: boolean;
+  onClick?: MouseEventHandler<HTMLInputElement>;
+  onMouseDown?: MouseEventHandler<HTMLInputElement>;
+  labelOnClick?: MouseEventHandler<HTMLLabelElement>;
 }
 
 export const RealtimeCheckedInputGroup = (props: IRealtimeCheckedInputGroup) => {
@@ -54,7 +57,10 @@ export const RealtimeCheckedInputGroup = (props: IRealtimeCheckedInputGroup) =>
               key={option.label}
               firebasePath={option.firebasePath}
               className="me-2"
+              value={option.label}
               label={option.label}
+              onMouseDown={props.onMouseDown}
+              labelOnClick={props.labelOnClick}
               id={`${option.firebasePath}-${option.label}`}
             />
           ) : (
@@ -64,6 +70,8 @@ export const RealtimeCheckedInputGroup = (props: IRealtimeCheckedInputGroup) =>
               firebasePath={option.firebasePath}
               style={{ marginTop: '0.1rem' }}
               className="me-2"
+              onMouseDown={props.onMouseDown}
+              labelOnClick={props.labelOnClick}
               label={option.label}
             />
           );
diff --git a/src/main/webapp/app/shared/model/firebase/firebase.model.ts b/src/main/webapp/app/shared/model/firebase/firebase.model.ts
index e8dcd0895..c231392fd 100644
--- a/src/main/webapp/app/shared/model/firebase/firebase.model.ts
+++ b/src/main/webapp/app/shared/model/firebase/firebase.model.ts
@@ -223,6 +223,9 @@ export class Mutation {
   name_uuid: string = generateUuid();
   tumors: Tumor[] = [];
   tumors_uuid: string = generateUuid();
+  summary = '';
+  summary_review?: Review;
+  summary_uuid: string = generateUuid();
 
   // Germline
   mutation_specific_penetrance = new MutationSpecificPenetrance();
diff --git a/src/main/webapp/app/shared/util/firebase/firebase-utils.tsx b/src/main/webapp/app/shared/util/firebase/firebase-utils.tsx
index 6c9cf5ca0..ef2cddc36 100644
--- a/src/main/webapp/app/shared/util/firebase/firebase-utils.tsx
+++ b/src/main/webapp/app/shared/util/firebase/firebase-utils.tsx
@@ -400,8 +400,12 @@ const addDuplicateMutationInfo = (duplicates: DuplicateMutationInfo[], mutationN
   }
 };
 
+export const hasMultipleMutations = (mutationName: string) => {
+  return mutationName.includes(',');
+};
 export const isMutationEffectCuratable = (mutationName: string) => {
-  if (mutationName.includes(',')) {
+  const multipleMuts = hasMultipleMutations(mutationName);
+  if (multipleMuts) {
     return false;
   }
   const excludedMutations = ['Oncogenic Mutations'];
diff --git a/src/test/javascript/screenshots/baseline/desktop_chrome/mutation-effect-not-curatable--1920x1080.png b/src/test/javascript/screenshots/baseline/desktop_chrome/mutation-effect-not-curatable--1920x1080.png
index d67a2deb1..7fc9adc4c 100644
Binary files a/src/test/javascript/screenshots/baseline/desktop_chrome/mutation-effect-not-curatable--1920x1080.png and b/src/test/javascript/screenshots/baseline/desktop_chrome/mutation-effect-not-curatable--1920x1080.png differ
diff --git a/src/test/javascript/screenshots/baseline/desktop_chrome/open-therapy-collapsible--1920x1080.png b/src/test/javascript/screenshots/baseline/desktop_chrome/open-therapy-collapsible--1920x1080.png
index 3ef61b63a..922142bb6 100644
Binary files a/src/test/javascript/screenshots/baseline/desktop_chrome/open-therapy-collapsible--1920x1080.png and b/src/test/javascript/screenshots/baseline/desktop_chrome/open-therapy-collapsible--1920x1080.png differ
diff --git a/src/test/javascript/screenshots/baseline/desktop_chrome/relevant-cancer-types-modal--1920x1080.png b/src/test/javascript/screenshots/baseline/desktop_chrome/relevant-cancer-types-modal--1920x1080.png
index cf2ed35f2..18a41e15e 100644
Binary files a/src/test/javascript/screenshots/baseline/desktop_chrome/relevant-cancer-types-modal--1920x1080.png and b/src/test/javascript/screenshots/baseline/desktop_chrome/relevant-cancer-types-modal--1920x1080.png differ