diff --git a/packages/vite/src/runtime/vite-node.mjs b/packages/vite/src/runtime/vite-node.mjs
index dcf89ccc97c..88b63e3fb21 100644
--- a/packages/vite/src/runtime/vite-node.mjs
+++ b/packages/vite/src/runtime/vite-node.mjs
@@ -22,5 +22,6 @@ export default async (ssrContext) => {
   process.server = true
   render = render || (await runner.executeFile(viteNodeOptions.entryPath)).default
   const result = await render(ssrContext)
+  runner.moduleCache.clear()
   return result
 }