diff --git a/deps/v8/src/isolate.h b/deps/v8/src/isolate.h
index 9ef6fc732a9f..ca3dfb8bdeda 100644
--- a/deps/v8/src/isolate.h
+++ b/deps/v8/src/isolate.h
@@ -384,6 +384,11 @@ class Isolate {
  public:
   ~Isolate();
 
+  // ISSUE-14576: allow to access process_wide_mutex_ from sampler.cc
+  static base::LazyMutex GetProcessWideMutex() {
+    return process_wide_mutex_;
+  }
+
   // A thread has a PerIsolateThreadData instance for each isolate that it has
   // entered. That instance is allocated when the isolate is initially entered
   // and reused on subsequent entries.
diff --git a/deps/v8/src/sampler.cc b/deps/v8/src/sampler.cc
index 0be31b51b08d..e9ad8a7ddb0a 100644
--- a/deps/v8/src/sampler.cc
+++ b/deps/v8/src/sampler.cc
@@ -342,6 +342,15 @@ void SignalHandler::HandleProfilerSignal(int signal, siginfo_t* info,
     // We require a fully initialized and entered isolate.
     return;
   }
+
+  // ISSUE-14576: To avoid deadlock, return if there is a thread lock
+  if (Isolate::GetProcessWideMutex().Pointer()->TryLock()) {
+    Isolate::GetProcessWideMutex().Pointer()->Unlock();
+  }
+  else {
+    return;
+  }
+
   if (v8::Locker::IsActive() &&
       !isolate->thread_manager()->IsLockedByCurrentThread()) {
     return;