diff --git a/.changeset/slimy-rocks-talk.md b/.changeset/slimy-rocks-talk.md
new file mode 100644
index 0000000000..12d8591216
--- /dev/null
+++ b/.changeset/slimy-rocks-talk.md
@@ -0,0 +1,5 @@
+---
+"@navikt/ds-react": patch
+---
+
+Remove tabIndex="-1" on Popover to fix VoiceOver navigation issue inside Popover
diff --git a/@navikt/core/react/src/popover/Popover.tsx b/@navikt/core/react/src/popover/Popover.tsx
index 764209c2c7..70a8fc9325 100644
--- a/@navikt/core/react/src/popover/Popover.tsx
+++ b/@navikt/core/react/src/popover/Popover.tsx
@@ -210,7 +210,6 @@ export const Popover = forwardRef<HTMLDivElement, PopoverProps>(
         })}
         data-placement={flPlacement}
         aria-hidden={!open || !anchorEl}
-        tabIndex={-1}
         {...getFloatingProps({
           ref: floatingRef,
           style: {
@@ -218,6 +217,7 @@ export const Popover = forwardRef<HTMLDivElement, PopoverProps>(
             top: y ?? 0,
             left: x ?? 0,
           },
+          tabIndex: undefined,
         })}
         {...rest}
       >