diff --git a/CMakeLists.txt b/CMakeLists.txt
index ba2e1388..0d1deb31 100644
--- a/CMakeLists.txt
+++ b/CMakeLists.txt
@@ -14,14 +14,33 @@ project(PythonQt)
 #----------------------------------------------------------------------------
 # Qt version
 
+# Sanity checks
+if(DEFINED Qt5_DIR AND DEFINED QT_QMAKE_EXECUTABLE)
+  message(FATAL_ERROR
+    "${PROJECT_NAME} shoult NOT be configured setting both Qt5_DIR and QT_QMAKE_EXECUTABLE options.
+To build with Qt4, specify QT_QMAKE_EXECUTABLE. To build with Qt5, specify  Qt5_DIR.")
+endif()
+
 # Set PythonQt_QT_VERSION
-set(PythonQt_QT_VERSION 4)
+if(DEFINED Qt5_DIR)
+  message(STATUS "${PROJECT_NAME}: Setting PythonQt_QT_VERSION to 5 because Qt5_DIR is defined.")
+  set(PythonQt_QT_VERSION 5)
+elseif(DEFINED QT_QMAKE_EXECUTABLE)
+  message(STATUS "${PROJECT_NAME}: Setting PythonQt_QT_VERSION to 4 because QT_QMAKE_EXECUTABLE is defined.")
+  set(PythonQt_QT_VERSION 4)
+else()
+  set(PythonQt_QT_VERSION 4 CACHE STRING "Pick a version of Qt to use: 4 or 5")
+  # Set the possible values of Qt version for cmake-gui
+  set_property(CACHE PythonQt_QT_VERSION PROPERTY STRINGS "4" "5")
+endif()
 
 # Requirements
+set(minimum_required_qt5_version "5.3.0")
 set(minimum_required_qt4_version "4.6.2")
 set(minimum_required_qt_version ${minimum_required_qt${PythonQt_QT_VERSION}_version})
 
 # Qt components
+set(qt5libs Core Widgets Network OpenGL Sql Svg UiTools WebKitWidgets Xml XmlPatterns)
 set(qt4libs core gui network opengl sql svg uitools webkit xml xmlpatterns)
 set(qtlibs ${qt${PythonQt_QT_VERSION}libs})
 
@@ -54,15 +73,32 @@ if(NOT DEFINED PythonQt_INSTALL_INCLUDE_DIR)
   set(PythonQt_INSTALL_INCLUDE_DIR include/PythonQt)
 endif()
 
+# Since the Qt bindings sources used for both Qt4 and Qt5 are
+# grouped using Qt4 naming convention, qt_wrapped_libs variables are the
+# same for the two Qt versions.
 set(qt4_wrapped_libs ${qt4libs})
+set(qt5_wrapped_libs ${qt4libs})
 set(qt_wrapped_libs ${qt${PythonQt_QT_VERSION}_wrapped_libs})
 
+set(qt5_wrapped_lib_depends_gui Multimedia)
+
+set(qtlib_to_wraplib_Widgets gui)
+set(qtlib_to_wraplib_WebKitWidgets webkit)
+
 # Define PythonQt_Wrap_Qt* options
 option(PythonQt_Wrap_QtAll "Make all Qt components available in python" OFF)
 foreach(qtlib ${qt_wrapped_libs})
   OPTION(PythonQt_Wrap_Qt${qtlib} "Make all of Qt${qtlib} available in python" OFF)
 endforeach()
 
+# Set qtlib_to_wraplib_* variables
+foreach(qtlib ${qtlibs})
+  string(TOLOWER ${qtlib} qtlib_lowercase)
+  if(DEFINED qtlib_to_wraplib_${qtlib})
+    set(qtlib_lowercase ${qtlib_to_wraplib_${qtlib}})
+  endif()
+  set(qtlib_to_wraplib_${qtlib} ${qtlib_lowercase})
+endforeach()
 
 # Force option if it applies
 if(PythonQt_Wrap_QtAll)
@@ -89,46 +125,86 @@ endif()
 #-----------------------------------------------------------------------------
 # Setup Qt
 
+if(PythonQt_QT_VERSION VERSION_GREATER "4")
 
-find_package(Qt4)
+  # Required components
+  set(qt_required_components Core Widgets)
+  foreach(qtlib ${qtlibs})
+    set(qt_wrapped_lib ${qtlib_to_wraplib_${qtlib}})
+    if(${PythonQt_Wrap_Qt${qt_wrapped_lib}})
+      list(APPEND qt_required_components ${qtlib} ${qt${PythonQt_QT_VERSION}_wrapped_lib_depends_${qt_wrapped_lib}})
+    endif()
+  endforeach()
+  if(BUILD_TESTING)
+    list(APPEND qt_required_components Test)
+  endif()
+  list(REMOVE_DUPLICATES qt_required_components)
 
-if(QT4_FOUND)
+  message(STATUS "${PROJECT_NAME}: Required Qt components [${qt_required_components}]")
+  find_package(Qt5 ${minimum_required_qt_version} COMPONENTS ${qt_required_components} REQUIRED)
 
-  set(found_qt_version ${QT_VERSION_MAJOR}.${QT_VERSION_MINOR}.${QT_VERSION_PATCH})
+  set(QT_LIBRARIES )
+  foreach(qtlib ${qt_required_components})
+    include_directories(${Qt5${qtlib}_INCLUDE_DIRS})
+    add_definitions(${Qt5${qtlib}_DEFINITIONS})
+    list(APPEND QT_LIBRARIES ${Qt5${qtlib}_LIBRARIES})
+  endforeach()
 
-  if(${found_qt_version} VERSION_LESS ${minimum_required_qt_version})
-      message(FATAL_ERROR "error: PythonQt requires Qt >= ${minimum_required_qt_version} -- you cannot use Qt ${found_qt_version}.")
-  endif()
+  set(QT_VERSION_MAJOR ${Qt5Core_VERSION_MAJOR})
+  set(QT_VERSION_MINOR ${Qt5Core_VERSION_MINOR})
+
+  macro(pythonqt_wrap_cpp)
+    qt5_wrap_cpp(${ARGV})
+  endmacro()
 
-  # Enable required qt module
-  foreach(qtlib ${qt_wrapped_libs})
-    string(TOUPPER ${qtlib} qtlib_uppercase)
-    if (NOT ${QT_QT${qtlib_uppercase}_FOUND})
-      message(FATAL_ERROR "QT_QT${qtlib_uppercase} *not* FOUND - Try to disable PythonQt_Wrap_Qt${qtlib}")
+else()
+
+  find_package(Qt4)
+
+  if(QT4_FOUND)
+
+    set(found_qt_version ${QT_VERSION_MAJOR}.${QT_VERSION_MINOR}.${QT_VERSION_PATCH})
+
+    if(${found_qt_version} VERSION_LESS ${minimum_required_qt_version})
+      message(FATAL_ERROR "error: PythonQt requires Qt >= ${minimum_required_qt_version} -- you cannot use Qt ${found_qt_version}.")
     endif()
-    set(QT_USE_QT${qtlib_uppercase} ${PythonQt_Wrap_Qt${qtlib}})
-  endforeach()
 
-  set(QT_USE_QTTEST ${BUILD_TESTING})
+    # Enable required qt module
+    foreach(qtlib ${qt_wrapped_libs})
+      string(TOUPPER ${qtlib} qtlib_uppercase)
+      if (NOT ${QT_QT${qtlib_uppercase}_FOUND})
+        message(FATAL_ERROR "QT_QT${qtlib_uppercase} *not* FOUND - Try to disable PythonQt_Wrap_Qt${qtlib}")
+      endif()
+      set(QT_USE_QT${qtlib_uppercase} ${PythonQt_Wrap_Qt${qtlib}})
+    endforeach()
 
-  include(${QT_USE_FILE})
-else()
-  message(FATAL_ERROR "error: Qt4 was not found on your system. You probably need to set the QT_QMAKE_EXECUTABLE variable")
-endif()
+    # Enable QtTest in Qt4 is the option BUILD_TESTING was activated
+    set(QT_USE_QTTEST ${BUILD_TESTING})
 
-macro(pythonqt_wrap_cpp)
-  qt4_wrap_cpp(${ARGV})
-endmacro()
+    include(${QT_USE_FILE})
+  else()
+    message(FATAL_ERROR "error: Qt4 was not found on your system. You probably need to set the QT_QMAKE_EXECUTABLE variable")
+  endif()
+
+  macro(pythonqt_wrap_cpp)
+    qt4_wrap_cpp(${ARGV})
+  endmacro()
+
+endif()
 
 #-----------------------------------------------------------------------------
 # The variable "generated_cpp_suffix" allows to conditionnally compile the generated wrappers
 # associated with the Qt version being used.
 
 set(generated_cpp_suffix_46 _47)
+set(generated_cpp_suffix_52 _50)
+set(generated_cpp_suffix_51 _50)
 
 set(generated_cpp_suffix "_${QT_VERSION_MAJOR}${QT_VERSION_MINOR}")
 if(DEFINED generated_cpp_suffix_${QT_VERSION_MAJOR}${QT_VERSION_MINOR})
   set(generated_cpp_suffix "${generated_cpp_suffix_${QT_VERSION_MAJOR}${QT_VERSION_MINOR}}")
+elseif(${QT_VERSION_MAJOR}.${QT_VERSION_MINOR} VERSION_GREATER "5.4")
+  set(generated_cpp_suffix "_54")
 endif()
 
 #-----------------------------------------------------------------------------
@@ -216,7 +292,7 @@ foreach(qtlib ${qt_wrapped_libs})
 
     set(file_prefix generated_cpp${generated_cpp_suffix}/com_trolltech_qt_${qtlib}/com_trolltech_qt_${qtlib})
 
-    foreach(index RANGE 0 11)
+    foreach(index RANGE 0 12)
 
       # Source files
       if(EXISTS ${CMAKE_CURRENT_SOURCE_DIR}/${file_prefix}${index}.cpp)
diff --git a/generated_cpp_50/PythonQt_QtBindings.cpp b/generated_cpp_50/PythonQt_QtBindings.cpp
new file mode 100644
index 00000000..7ae1630a
--- /dev/null
+++ b/generated_cpp_50/PythonQt_QtBindings.cpp
@@ -0,0 +1,58 @@
+
+#include "PythonQt_QtBindings.h"
+
+#include "PythonQt.h"
+
+void PythonQt_init_QtGui(PyObject*);
+void PythonQt_init_QtSvg(PyObject*);
+void PythonQt_init_QtSql(PyObject*);
+void PythonQt_init_QtNetwork(PyObject*);
+void PythonQt_init_QtCore(PyObject*);
+void PythonQt_init_QtWebKit(PyObject*);
+void PythonQt_init_QtOpenGL(PyObject*);
+void PythonQt_init_QtXml(PyObject*);
+void PythonQt_init_QtXmlPatterns(PyObject*);
+void PythonQt_init_QtUiTools(PyObject*);
+
+PYTHONQT_EXPORT void PythonQt_init_QtBindings()
+  {
+  #ifdef PYTHONQT_WRAP_Qtcore
+  PythonQt_init_QtCore(0);
+  #endif
+
+  #ifdef PYTHONQT_WRAP_Qtgui
+  PythonQt_init_QtGui(0);
+  #endif
+
+  #ifdef PYTHONQT_WRAP_Qtnetwork
+  PythonQt_init_QtNetwork(0);
+  #endif
+
+  #ifdef PYTHONQT_WRAP_Qtopengl
+  PythonQt_init_QtOpenGL(0);
+  #endif
+
+  #ifdef PYTHONQT_WRAP_Qtsql
+  PythonQt_init_QtSql(0);
+  #endif
+
+  #ifdef PYTHONQT_WRAP_Qtsvg
+  PythonQt_init_QtSvg(0);
+  #endif
+
+  #ifdef PYTHONQT_WRAP_Qtuitools
+  PythonQt_init_QtUiTools(0);
+  #endif
+
+  #ifdef PYTHONQT_WRAP_Qtwebkit
+  PythonQt_init_QtWebKit(0);
+  #endif
+
+  #ifdef PYTHONQT_WRAP_Qtxml
+  PythonQt_init_QtXml(0);
+  #endif
+
+  #ifdef PYTHONQT_WRAP_Qtxmlpatterns
+  PythonQt_init_QtXmlPatterns(0);
+  #endif
+  };
diff --git a/generated_cpp_50/PythonQt_QtBindings.h b/generated_cpp_50/PythonQt_QtBindings.h
new file mode 100644
index 00000000..03e96aed
--- /dev/null
+++ b/generated_cpp_50/PythonQt_QtBindings.h
@@ -0,0 +1,10 @@
+#ifndef _PYTHONQT_QTBINDINGS_H
+#define _PYTHONQT_QTBINDINGS_H
+
+#include "PythonQtSystem.h"
+
+/// Initialize Qt bindings enabled at configuration time
+PYTHONQT_EXPORT void PythonQt_init_QtBindings();
+
+#endif
+
diff --git a/generated_cpp_53/PythonQt_QtBindings.cpp b/generated_cpp_53/PythonQt_QtBindings.cpp
new file mode 100644
index 00000000..7ae1630a
--- /dev/null
+++ b/generated_cpp_53/PythonQt_QtBindings.cpp
@@ -0,0 +1,58 @@
+
+#include "PythonQt_QtBindings.h"
+
+#include "PythonQt.h"
+
+void PythonQt_init_QtGui(PyObject*);
+void PythonQt_init_QtSvg(PyObject*);
+void PythonQt_init_QtSql(PyObject*);
+void PythonQt_init_QtNetwork(PyObject*);
+void PythonQt_init_QtCore(PyObject*);
+void PythonQt_init_QtWebKit(PyObject*);
+void PythonQt_init_QtOpenGL(PyObject*);
+void PythonQt_init_QtXml(PyObject*);
+void PythonQt_init_QtXmlPatterns(PyObject*);
+void PythonQt_init_QtUiTools(PyObject*);
+
+PYTHONQT_EXPORT void PythonQt_init_QtBindings()
+  {
+  #ifdef PYTHONQT_WRAP_Qtcore
+  PythonQt_init_QtCore(0);
+  #endif
+
+  #ifdef PYTHONQT_WRAP_Qtgui
+  PythonQt_init_QtGui(0);
+  #endif
+
+  #ifdef PYTHONQT_WRAP_Qtnetwork
+  PythonQt_init_QtNetwork(0);
+  #endif
+
+  #ifdef PYTHONQT_WRAP_Qtopengl
+  PythonQt_init_QtOpenGL(0);
+  #endif
+
+  #ifdef PYTHONQT_WRAP_Qtsql
+  PythonQt_init_QtSql(0);
+  #endif
+
+  #ifdef PYTHONQT_WRAP_Qtsvg
+  PythonQt_init_QtSvg(0);
+  #endif
+
+  #ifdef PYTHONQT_WRAP_Qtuitools
+  PythonQt_init_QtUiTools(0);
+  #endif
+
+  #ifdef PYTHONQT_WRAP_Qtwebkit
+  PythonQt_init_QtWebKit(0);
+  #endif
+
+  #ifdef PYTHONQT_WRAP_Qtxml
+  PythonQt_init_QtXml(0);
+  #endif
+
+  #ifdef PYTHONQT_WRAP_Qtxmlpatterns
+  PythonQt_init_QtXmlPatterns(0);
+  #endif
+  };
diff --git a/generated_cpp_53/PythonQt_QtBindings.h b/generated_cpp_53/PythonQt_QtBindings.h
new file mode 100644
index 00000000..03e96aed
--- /dev/null
+++ b/generated_cpp_53/PythonQt_QtBindings.h
@@ -0,0 +1,10 @@
+#ifndef _PYTHONQT_QTBINDINGS_H
+#define _PYTHONQT_QTBINDINGS_H
+
+#include "PythonQtSystem.h"
+
+/// Initialize Qt bindings enabled at configuration time
+PYTHONQT_EXPORT void PythonQt_init_QtBindings();
+
+#endif
+
diff --git a/generated_cpp_54/PythonQt_QtBindings.cpp b/generated_cpp_54/PythonQt_QtBindings.cpp
new file mode 100644
index 00000000..7ae1630a
--- /dev/null
+++ b/generated_cpp_54/PythonQt_QtBindings.cpp
@@ -0,0 +1,58 @@
+
+#include "PythonQt_QtBindings.h"
+
+#include "PythonQt.h"
+
+void PythonQt_init_QtGui(PyObject*);
+void PythonQt_init_QtSvg(PyObject*);
+void PythonQt_init_QtSql(PyObject*);
+void PythonQt_init_QtNetwork(PyObject*);
+void PythonQt_init_QtCore(PyObject*);
+void PythonQt_init_QtWebKit(PyObject*);
+void PythonQt_init_QtOpenGL(PyObject*);
+void PythonQt_init_QtXml(PyObject*);
+void PythonQt_init_QtXmlPatterns(PyObject*);
+void PythonQt_init_QtUiTools(PyObject*);
+
+PYTHONQT_EXPORT void PythonQt_init_QtBindings()
+  {
+  #ifdef PYTHONQT_WRAP_Qtcore
+  PythonQt_init_QtCore(0);
+  #endif
+
+  #ifdef PYTHONQT_WRAP_Qtgui
+  PythonQt_init_QtGui(0);
+  #endif
+
+  #ifdef PYTHONQT_WRAP_Qtnetwork
+  PythonQt_init_QtNetwork(0);
+  #endif
+
+  #ifdef PYTHONQT_WRAP_Qtopengl
+  PythonQt_init_QtOpenGL(0);
+  #endif
+
+  #ifdef PYTHONQT_WRAP_Qtsql
+  PythonQt_init_QtSql(0);
+  #endif
+
+  #ifdef PYTHONQT_WRAP_Qtsvg
+  PythonQt_init_QtSvg(0);
+  #endif
+
+  #ifdef PYTHONQT_WRAP_Qtuitools
+  PythonQt_init_QtUiTools(0);
+  #endif
+
+  #ifdef PYTHONQT_WRAP_Qtwebkit
+  PythonQt_init_QtWebKit(0);
+  #endif
+
+  #ifdef PYTHONQT_WRAP_Qtxml
+  PythonQt_init_QtXml(0);
+  #endif
+
+  #ifdef PYTHONQT_WRAP_Qtxmlpatterns
+  PythonQt_init_QtXmlPatterns(0);
+  #endif
+  };
diff --git a/generated_cpp_54/PythonQt_QtBindings.h b/generated_cpp_54/PythonQt_QtBindings.h
new file mode 100644
index 00000000..03e96aed
--- /dev/null
+++ b/generated_cpp_54/PythonQt_QtBindings.h
@@ -0,0 +1,10 @@
+#ifndef _PYTHONQT_QTBINDINGS_H
+#define _PYTHONQT_QTBINDINGS_H
+
+#include "PythonQtSystem.h"
+
+/// Initialize Qt bindings enabled at configuration time
+PYTHONQT_EXPORT void PythonQt_init_QtBindings();
+
+#endif
+