diff --git a/src/tests/issues.targets b/src/tests/issues.targets
index 1724254d8ad89..ef552d58497b3 100644
--- a/src/tests/issues.targets
+++ b/src/tests/issues.targets
@@ -624,6 +624,33 @@
         <ExcludeList Include="$(XunitTestBinBase)/JIT/superpmi/superpmicollect/*">
             <Issue>Not compatible with crossgen2</Issue>
         </ExcludeList>
+        <ExcludeList Include="$(XunitTestBinBase)/Loader/classloader/StaticVirtualMethods/GenericContext/GenericContextTestDefaultImp/**">
+            <Issue>https://github.com/dotnet/runtime/issues/109200</Issue>
+        </ExcludeList>
+        <ExcludeList Include="$(XunitTestBinBase)/Loader/classloader/StaticVirtualMethods/GenericContext/GenericContextTest/**">
+            <Issue>https://github.com/dotnet/runtime/issues/109200</Issue>
+        </ExcludeList>
+        <ExcludeList Include="$(XunitTestBinBase)/Loader/classloader/StaticVirtualMethods/NegativeTestCases/VarianceSafety/**">
+            <Issue>https://github.com/dotnet/runtime/issues/109201</Issue>
+        </ExcludeList>
+        <ExcludeList Include="$(XunitTestBinBase)/Regressions/coreclr/GitHub_68278/**">
+            <Issue>https://github.com/dotnet/runtime/issues/108255</Issue>
+        </ExcludeList>
+        <ExcludeList Include="$(XunitTestBinBase)/JIT/BBT/Scenario4/Not-Int32/**">
+            <Issue>https://github.com/dotnet/runtime/issues/108255</Issue>
+        </ExcludeList>
+        <ExcludeList Include="$(XunitTestBinBase)/Loader/classloader/generics/Variance/Methods/Method002/**">
+            <Issue>https://github.com/dotnet/runtime/issues/109202</Issue>
+        </ExcludeList>
+        <ExcludeList Include="$(XunitTestBinBase)/JIT/Regression/JitBlue/Runtime_72845/**">
+            <Issue>https://github.com/dotnet/runtime/issues/108255</Issue>
+        </ExcludeList>
+        <ExcludeList Include="$(XunitTestBinBase)/JIT/Regression/JitBlue/Runtime_87393/**">
+            <Issue>https://github.com/dotnet/runtime/issues/108255</Issue>
+        </ExcludeList>
+        <ExcludeList Include="$(XunitTestBinBase)/baseservices/multidimmarray/rank1array/**">
+            <Issue>https://github.com/dotnet/runtime/issues/108255</Issue>
+        </ExcludeList>
     </ItemGroup>
 
     <!-- Crossgen2 x86 specific excludes -->