diff --git a/tools/ci_build/build.py b/tools/ci_build/build.py
index fdc85e2cafa31..6ee37b8b0519e 100644
--- a/tools/ci_build/build.py
+++ b/tools/ci_build/build.py
@@ -1559,6 +1559,9 @@ def generate_build_tree(
                 # The "/profile" flag implies "/DEBUG:FULL /DEBUGTYPE:cv,fixup /OPT:REF /OPT:NOICF /INCREMENTAL:NO /FIXED:NO". We set it for satisfying a Microsoft internal compliance requirement. External users
                 # do not need to have it.
                 ldflags = ["/profile", "/DYNAMICBASE"]
+                # Address Sanitizer libs do not have a Qspectre version. So they two cannot be both enabled.
+                if not args.enable_address_sanitizer:
+                    cflags += ["/Qspectre"]
                 if config == "Release":
                     cflags += ["/O2", "/Ob2", "/DNDEBUG"]
                 elif config == "RelWithDebInfo":