diff --git a/nuget/Microsoft.Windows.CsWinRT.Embedded.targets b/nuget/Microsoft.Windows.CsWinRT.Embedded.targets
index 81535cf1e..ff38fa69c 100644
--- a/nuget/Microsoft.Windows.CsWinRT.Embedded.targets
+++ b/nuget/Microsoft.Windows.CsWinRT.Embedded.targets
@@ -68,7 +68,7 @@ Copyright (C) Microsoft Corporation. All rights reserved.
     <ItemGroup>
       <Reference Remove="WinRT.Runtime" /> 
       <RuntimeCopyLocalItems Remove="@(RuntimeCopyLocalItems)" Condition="'%(DestinationSubPath)' == 'WinRT.Runtime.dll'"/>
-      <ResolvedCompileFileDefinitions Remove="@(ResolvedCompileFileDefinitions)" Condition="'%(HintPath)' == '$(CsWinRTPath)lib\net5.0\WinRT.Runtime.dll'"/>
+      <ResolvedCompileFileDefinitions Remove="@(ResolvedCompileFileDefinitions)" Condition="'%(HintPath)' == '$(CsWinRTPath)lib\net6.0\WinRT.Runtime.dll'"/>
     </ItemGroup>
 
   </Target>
diff --git a/nuget/Microsoft.Windows.CsWinRT.targets b/nuget/Microsoft.Windows.CsWinRT.targets
index f5d180a2d..1e7f531f3 100644
--- a/nuget/Microsoft.Windows.CsWinRT.targets
+++ b/nuget/Microsoft.Windows.CsWinRT.targets
@@ -20,6 +20,10 @@ Copyright (C) Microsoft Corporation. All rights reserved.
 
   <Import Project="$(MSBuildThisFileDirectory)Microsoft.Windows.CsWinRT.Embedded.targets" Condition="'$(CsWinRTEmbedded)' == 'true'"/>
   
+  <Target Name="CsWinRTNet5EOL" Condition="$([MSBuild]::GetTargetFrameworkVersion('$(TargetFramework)')) == 5" BeforeTargets="CsWinRTPrepareProjection">
+    <Error Text="Support for .NET 5 ended with C#/WinRT 2.0. For .NET 5 support, use C#/WinRT version 1.6.5. See https://github.com/microsoft/CsWinRT/discussions/1232" />
+  </Target>
+
   <!-- Remove WinRT.Host.dll and WinRT.Host.Shim.dll references -->
   <Target Name="CsWinRTRemoveHostingDllReferences" AfterTargets="ResolvePackageAssets" BeforeTargets="ResolveLockFileAnalyzers" Outputs="@(Reference)">
     <PropertyGroup>
diff --git a/src/Directory.Build.targets b/src/Directory.Build.targets
index 3561262d3..56cb6ce73 100644
--- a/src/Directory.Build.targets
+++ b/src/Directory.Build.targets
@@ -25,6 +25,8 @@
 
   <Import Condition="'$(MSBuildProjectExtension)' == '.csproj' and '$(SimulateCsWinRTNugetReference)' == 'true'" Project="..\nuget\Microsoft.Windows.CsWinRT.targets" />
 
+  <Target Name="CsWinRTNet5EOL" />
+
   <Target Name="CsWinRTCheckDependencies" BeforeTargets="PrepareForBuild">
     <Error Condition="!Exists('$(SolutionDir)TestWinRT')" Text="This solution requires the TestWinRT repo, which is missing. Please run build.cmd from a Visual Studio command prompt." />
   </Target>
diff --git a/src/cswinrt/main.cpp b/src/cswinrt/main.cpp
index f4449b065..5e31591ed 100644
--- a/src/cswinrt/main.cpp
+++ b/src/cswinrt/main.cpp
@@ -32,7 +32,7 @@ namespace cswinrt
         { "output", 0, 1, "<path>", "Location of generated projection" },
         { "include", 0, option::no_max, "<prefix>", "One or more prefixes to include in projection" },
         { "exclude", 0, option::no_max, "<prefix>", "One or more prefixes to exclude from projection" },
-        { "target", 0, 1, "<net6.0|net5.0|netstandard2.0>", "Target TFM for projection. Omit for compatibility with newest TFM (net5.0)." },
+        { "target", 0, 1, "<net6.0|netstandard2.0>", "Target TFM for projection. Omit for compatibility with newest TFM (net6.0)." },
         { "component", 0, 0, {}, "Generate component projection." },
         { "verbose", 0, 0, {}, "Show detailed progress information" },
         { "internal", 0, 0, {}, "Generates a private projection."},