diff --git a/libpod/networking_slirp4netns.go b/libpod/networking_slirp4netns.go
index c06d215e1a..e24b54032a 100644
--- a/libpod/networking_slirp4netns.go
+++ b/libpod/networking_slirp4netns.go
@@ -16,6 +16,7 @@ import (
 	"syscall"
 	"time"
 
+	"github.com/containernetworking/plugins/pkg/ns"
 	"github.com/containers/podman/v3/pkg/errorhandling"
 	"github.com/containers/podman/v3/pkg/rootless"
 	"github.com/containers/podman/v3/pkg/rootlessport"
@@ -58,6 +59,8 @@ type slirp4netnsNetworkOptions struct {
 	outboundAddr6       string
 }
 
+const ipv6ConfDefaultAcceptDadSysctl = "/proc/sys/net/ipv6/conf/default/accept_dad"
+
 func checkSlirpFlags(path string) (*slirpFeatures, error) {
 	cmd := exec.Command(path, "--help")
 	out, err := cmd.CombinedOutput()
@@ -297,6 +300,39 @@ func (r *Runtime) setupSlirp4netns(ctr *Container) error {
 	}
 	cmd.Stdout = logFile
 	cmd.Stderr = logFile
+
+	var slirpReadyChan (chan struct{})
+
+	if netOptions.enableIPv6 {
+		slirpReadyChan = make(chan struct{})
+		defer close(slirpReadyChan)
+		go func() {
+			err := ns.WithNetNSPath(netnsPath, func(_ ns.NetNS) error {
+				// Duplicate Address Detection slows the ipv6 setup down for 1-2 seconds.
+				// Since slirp4netns is run it is own namespace and not directly routed
+				// we can skip this to make the ipv6 address immediately available.
+				// We change the default to make sure the slirp tap interface gets the
+				// correct value assigned so DAD is disabled for it
+				// Also make sure to change this value back to the original after slirp4netns
+				// is ready in case users rely on this sysctl.
+				orgValue, err := ioutil.ReadFile(ipv6ConfDefaultAcceptDadSysctl)
+				if err != nil {
+					return err
+				}
+				err = ioutil.WriteFile(ipv6ConfDefaultAcceptDadSysctl, []byte("0"), 0644)
+				if err != nil {
+					return err
+				}
+				// wait for slirp to finish setup
+				<-slirpReadyChan
+				return ioutil.WriteFile(ipv6ConfDefaultAcceptDadSysctl, orgValue, 0644)
+			})
+			if err != nil {
+				logrus.Warnf("failed to set net.ipv6.conf.default.accept_dad sysctl: %v", err)
+			}
+		}()
+	}
+
 	if err := cmd.Start(); err != nil {
 		return errors.Wrapf(err, "failed to start slirp4netns process")
 	}
@@ -310,6 +346,9 @@ func (r *Runtime) setupSlirp4netns(ctr *Container) error {
 	if err := waitForSync(syncR, cmd, logFile, 1*time.Second); err != nil {
 		return err
 	}
+	if slirpReadyChan != nil {
+		slirpReadyChan <- struct{}{}
+	}
 
 	// Set a default slirp subnet. Parsing a string with the net helper is easier than building the struct myself
 	_, ctr.slirp4netnsSubnet, _ = net.ParseCIDR(defaultSlirp4netnsSubnet)
diff --git a/test/e2e/run_networking_test.go b/test/e2e/run_networking_test.go
index 84707732bc..8d3b19b887 100644
--- a/test/e2e/run_networking_test.go
+++ b/test/e2e/run_networking_test.go
@@ -357,6 +357,26 @@ var _ = Describe("Podman run networking", func() {
 		Expect(ncBusy).To(ExitWithError())
 	})
 
+	It("podman run slirp4netns verify net.ipv6.conf.default.accept_dad=0", func() {
+		session := podmanTest.Podman([]string{"run", "--network", "slirp4netns:enable_ipv6=true", ALPINE, "ip", "addr"})
+		session.Wait(30)
+		Expect(session).Should(Exit(0))
+		// check the ipv6 setup id done without delay (https://github.com/containers/podman/issues/11062)
+		Expect(session.OutputToString()).To(ContainSubstring("inet6 fd00::"))
+
+		const ipv6ConfDefaultAcceptDadSysctl = "/proc/sys/net/ipv6/conf/all/accept_dad"
+
+		cat := SystemExec("cat", []string{ipv6ConfDefaultAcceptDadSysctl})
+		cat.Wait(30)
+		Expect(cat).Should(Exit(0))
+		sysctlValue := cat.OutputToString()
+
+		session = podmanTest.Podman([]string{"run", "--network", "slirp4netns:enable_ipv6=true", ALPINE, "cat", ipv6ConfDefaultAcceptDadSysctl})
+		session.Wait(30)
+		Expect(session).Should(Exit(0))
+		Expect(session.OutputToString()).To(Equal(sysctlValue))
+	})
+
 	It("podman run network expose host port 18082 to container port 8000 using slirp4netns port handler", func() {
 		session := podmanTest.Podman([]string{"run", "--network", "slirp4netns:port_handler=slirp4netns", "-dt", "-p", "18082:8000", ALPINE, "/bin/sh"})
 		session.Wait(30)