diff --git a/pkg/specgen/generate/container_create.go b/pkg/specgen/generate/container_create.go
index a7a7353d08..28c31c7ebb 100644
--- a/pkg/specgen/generate/container_create.go
+++ b/pkg/specgen/generate/container_create.go
@@ -267,7 +267,16 @@ func createContainerOptions(ctx context.Context, rt *libpod.Runtime, s *specgen.
 				"/usr/sbin/init":       true,
 				"/usr/local/sbin/init": true,
 			}
-			if useSystemdCommands[command[0]] || (filepath.Base(command[0]) == "systemd") {
+			// Grab last command incase this is launched from a shell
+			cmd := command
+			if len(command) > 2 {
+				// Podman build will add "/bin/sh" "-c" to
+				// Entrypoint. Remove and search for systemd
+				if command[0] == "/bin/sh" && command[1] == "-c" {
+					cmd = command[2:]
+				}
+			}
+			if useSystemdCommands[cmd[0]] || (filepath.Base(cmd[0]) == "systemd") {
 				useSystemd = true
 			}
 		}
diff --git a/test/e2e/systemd_test.go b/test/e2e/systemd_test.go
index f8d8db592b..57fc323ce4 100644
--- a/test/e2e/systemd_test.go
+++ b/test/e2e/systemd_test.go
@@ -1,8 +1,10 @@
 package integration
 
 import (
+	"fmt"
 	"io/ioutil"
 	"os"
+	"path/filepath"
 	"strings"
 
 	. "github.com/containers/podman/v4/test/utils"
@@ -130,6 +132,31 @@ WantedBy=default.target
 		Expect(conData[0].Config.SystemdMode).To(BeTrue())
 	})
 
+	It("podman systemd in command triggers systemd mode", func() {
+		containerfile := fmt.Sprintf(`FROM %s
+RUN mkdir -p /usr/lib/systemd/; touch /usr/lib/systemd/systemd
+CMD /usr/lib/systemd/systemd`, ALPINE)
+
+		containerfilePath := filepath.Join(podmanTest.TempDir, "Containerfile")
+		err := ioutil.WriteFile(containerfilePath, []byte(containerfile), 0755)
+		Expect(err).To(BeNil())
+		session := podmanTest.Podman([]string{"build", "-t", "systemd", "--file", containerfilePath, podmanTest.TempDir})
+		session.WaitWithDefaultTimeout()
+		Expect(session).Should(Exit(0))
+
+		ctrName := "testCtr"
+		run := podmanTest.Podman([]string{"create", "--name", ctrName, "systemd"})
+		run.WaitWithDefaultTimeout()
+		Expect(run).Should(Exit(0))
+
+		result := podmanTest.Podman([]string{"inspect", ctrName})
+		result.WaitWithDefaultTimeout()
+		Expect(result).Should(Exit(0))
+		conData := result.InspectContainerToJSON()
+		Expect(conData).To(HaveLen(1))
+		Expect(conData[0].Config.SystemdMode).To(BeTrue())
+	})
+
 	It("podman create container with --uidmap and conmon PidFile accessible", func() {
 		ctrName := "testCtrUidMap"
 		run := podmanTest.Podman([]string{"run", "-d", "--uidmap=0:1:1000", "--name", ctrName, ALPINE, "top"})