diff --git a/changelog.d/12227.bugfix b/changelog.d/12227.bugfix
new file mode 100644
index 000000000000..1a7dccf46568
--- /dev/null
+++ b/changelog.d/12227.bugfix
@@ -0,0 +1 @@
+Fix a long-standing bug where events from ignored users were still considered for relations.
diff --git a/changelog.d/12227.misc b/changelog.d/12227.misc
deleted file mode 100644
index 41c9dcbd37f6..000000000000
--- a/changelog.d/12227.misc
+++ /dev/null
@@ -1 +0,0 @@
-Refactor the relations endpoints to add a `RelationsHandler`.
diff --git a/changelog.d/12232.bugfix b/changelog.d/12232.bugfix
new file mode 100644
index 000000000000..1a7dccf46568
--- /dev/null
+++ b/changelog.d/12232.bugfix
@@ -0,0 +1 @@
+Fix a long-standing bug where events from ignored users were still considered for relations.
diff --git a/changelog.d/12232.misc b/changelog.d/12232.misc
deleted file mode 100644
index 4a4132edff2c..000000000000
--- a/changelog.d/12232.misc
+++ /dev/null
@@ -1 +0,0 @@
-Refactor relations tests to improve code re-use.
diff --git a/changelog.d/12285.bugfix b/changelog.d/12285.bugfix
new file mode 100644
index 000000000000..1a7dccf46568
--- /dev/null
+++ b/changelog.d/12285.bugfix
@@ -0,0 +1 @@
+Fix a long-standing bug where events from ignored users were still considered for relations.
diff --git a/synapse/handlers/relations.py b/synapse/handlers/relations.py
index 57135d45197b..73217d135d7c 100644
--- a/synapse/handlers/relations.py
+++ b/synapse/handlers/relations.py
@@ -21,6 +21,7 @@
 from synapse.api.errors import SynapseError
 from synapse.events import EventBase
 from synapse.types import JsonDict, Requester, StreamToken
+from synapse.visibility import filter_events_for_client
 
 if TYPE_CHECKING:
     from synapse.server import HomeServer
@@ -62,6 +63,7 @@ def __bool__(self) -> bool:
 class RelationsHandler:
     def __init__(self, hs: "HomeServer"):
         self._main_store = hs.get_datastores().main
+        self._storage = hs.get_storage()
         self._auth = hs.get_auth()
         self._clock = hs.get_clock()
         self._event_handler = hs.get_event_handler()
@@ -103,7 +105,8 @@ async def get_relations(
 
         user_id = requester.user.to_string()
 
-        await self._auth.check_user_in_room_or_world_readable(
+        # TODO Properly handle a user leaving a room.
+        (_, member_event_id) = await self._auth.check_user_in_room_or_world_readable(
             room_id, user_id, allow_departed_users=True
         )
 
@@ -130,6 +133,10 @@ async def get_relations(
             [c["event_id"] for c in pagination_chunk.chunk]
         )
 
+        events = await filter_events_for_client(
+            self._storage, user_id, events, is_peeking=(member_event_id is None)
+        )
+
         now = self._clock.time_msec()
         # Do not bundle aggregations when retrieving the original event because
         # we want the content before relations are applied to it.
diff --git a/tests/rest/client/test_relations.py b/tests/rest/client/test_relations.py
index 329690f8f7c8..fe97a0b3dde1 100644
--- a/tests/rest/client/test_relations.py
+++ b/tests/rest/client/test_relations.py
@@ -20,7 +20,7 @@
 
 from twisted.test.proto_helpers import MemoryReactor
 
-from synapse.api.constants import EventTypes, RelationTypes
+from synapse.api.constants import AccountDataTypes, EventTypes, RelationTypes
 from synapse.rest import admin
 from synapse.rest.client import login, register, relations, room, sync
 from synapse.server import HomeServer
@@ -1324,6 +1324,84 @@ def test_bundled_aggregations_with_filter(self) -> None:
         self.assertIn("m.relations", parent_event["unsigned"])
 
 
+class RelationIgnoredUserTestCase(BaseRelationsTestCase):
+    """Relations sent from an ignored user should be ignored."""
+
+    def _test_ignored_user(
+        self, allowed_event_ids: List[str], ignored_event_ids: List[str]
+    ) -> None:
+        """
+        Fetch the relations and ensure they're all there, then ignore user2, and
+        repeat.
+        """
+        # Get the relations.
+        event_ids = self._get_related_events()
+        self.assertCountEqual(event_ids, allowed_event_ids + ignored_event_ids)
+
+        # Ignore user2 and re-do the requests.
+        self.get_success(
+            self.store.add_account_data_for_user(
+                self.user_id,
+                AccountDataTypes.IGNORED_USER_LIST,
+                {"ignored_users": {self.user2_id: {}}},
+            )
+        )
+
+        # Get the relations.
+        event_ids = self._get_related_events()
+        self.assertCountEqual(event_ids, allowed_event_ids)
+
+    def test_annotation(self) -> None:
+        """Annotations should ignore"""
+        # Send 2 from us, 2 from the to be ignored user.
+        allowed_event_ids = []
+        ignored_event_ids = []
+        channel = self._send_relation(RelationTypes.ANNOTATION, "m.reaction", key="a")
+        allowed_event_ids.append(channel.json_body["event_id"])
+        channel = self._send_relation(RelationTypes.ANNOTATION, "m.reaction", key="b")
+        allowed_event_ids.append(channel.json_body["event_id"])
+        channel = self._send_relation(
+            RelationTypes.ANNOTATION,
+            "m.reaction",
+            key="a",
+            access_token=self.user2_token,
+        )
+        ignored_event_ids.append(channel.json_body["event_id"])
+        channel = self._send_relation(
+            RelationTypes.ANNOTATION,
+            "m.reaction",
+            key="c",
+            access_token=self.user2_token,
+        )
+        ignored_event_ids.append(channel.json_body["event_id"])
+
+        self._test_ignored_user(allowed_event_ids, ignored_event_ids)
+
+    def test_reference(self) -> None:
+        """Annotations should ignore"""
+        channel = self._send_relation(RelationTypes.REFERENCE, "m.room.test")
+        allowed_event_ids = [channel.json_body["event_id"]]
+
+        channel = self._send_relation(
+            RelationTypes.REFERENCE, "m.room.test", access_token=self.user2_token
+        )
+        ignored_event_ids = [channel.json_body["event_id"]]
+
+        self._test_ignored_user(allowed_event_ids, ignored_event_ids)
+
+    def test_thread(self) -> None:
+        """Annotations should ignore"""
+        channel = self._send_relation(RelationTypes.THREAD, "m.room.test")
+        allowed_event_ids = [channel.json_body["event_id"]]
+
+        channel = self._send_relation(
+            RelationTypes.THREAD, "m.room.test", access_token=self.user2_token
+        )
+        ignored_event_ids = [channel.json_body["event_id"]]
+
+        self._test_ignored_user(allowed_event_ids, ignored_event_ids)
+
+
 class RelationRedactionTestCase(BaseRelationsTestCase):
     """
     Test the behaviour of relations when the parent or child event is redacted.