diff --git a/changelog.d/10348.misc b/changelog.d/10348.misc
new file mode 100644
index 000000000000..b2275a1350b9
--- /dev/null
+++ b/changelog.d/10348.misc
@@ -0,0 +1 @@
+Run `pyupgrade` on the codebase.
\ No newline at end of file
diff --git a/synapse/app/generic_worker.py b/synapse/app/generic_worker.py
index 5b041fcaade2..40bab7fe5ecd 100644
--- a/synapse/app/generic_worker.py
+++ b/synapse/app/generic_worker.py
@@ -395,10 +395,8 @@ def start_listening(self):
             elif listener.type == "metrics":
                 if not self.config.enable_metrics:
                     logger.warning(
-                        (
-                            "Metrics listener configured, but "
-                            "enable_metrics is not True!"
-                        )
+                        "Metrics listener configured, but "
+                        "enable_metrics is not True!"
                     )
                 else:
                     _base.listen_metrics(listener.bind_addresses, listener.port)
diff --git a/synapse/app/homeserver.py b/synapse/app/homeserver.py
index 7af56ac13640..920b34d97bf4 100644
--- a/synapse/app/homeserver.py
+++ b/synapse/app/homeserver.py
@@ -305,10 +305,8 @@ def start_listening(self):
             elif listener.type == "metrics":
                 if not self.config.enable_metrics:
                     logger.warning(
-                        (
-                            "Metrics listener configured, but "
-                            "enable_metrics is not True!"
-                        )
+                        "Metrics listener configured, but "
+                        "enable_metrics is not True!"
                     )
                 else:
                     _base.listen_metrics(listener.bind_addresses, listener.port)
diff --git a/synapse/config/appservice.py b/synapse/config/appservice.py
index 746fc3cc02f6..68db59fd8956 100644
--- a/synapse/config/appservice.py
+++ b/synapse/config/appservice.py
@@ -64,7 +64,7 @@ def load_appservices(hostname, config_files):
 
     for config_file in config_files:
         try:
-            with open(config_file, "r") as f:
+            with open(config_file) as f:
                 appservice = _load_appservice(hostname, yaml.safe_load(f), config_file)
                 if appservice.id in seen_ids:
                     raise ConfigError(
diff --git a/synapse/config/tls.py b/synapse/config/tls.py
index 9a16a8fbae96..1ede827e308d 100644
--- a/synapse/config/tls.py
+++ b/synapse/config/tls.py
@@ -66,10 +66,8 @@ def read_config(self, config: dict, config_dir_path: str, **kwargs):
         if self.federation_client_minimum_tls_version == "1.3":
             if getattr(SSL, "OP_NO_TLSv1_3", None) is None:
                 raise ConfigError(
-                    (
-                        "federation_client_minimum_tls_version cannot be 1.3, "
-                        "your OpenSSL does not support it"
-                    )
+                    "federation_client_minimum_tls_version cannot be 1.3, "
+                    "your OpenSSL does not support it"
                 )
 
         # Whitelist of domains to not verify certificates for
diff --git a/synapse/handlers/cas.py b/synapse/handlers/cas.py
index 7346ccfe9396..87eeb4a5aa62 100644
--- a/synapse/handlers/cas.py
+++ b/synapse/handlers/cas.py
@@ -40,7 +40,7 @@ def __init__(self, error, error_description=None):
 
     def __str__(self):
         if self.error_description:
-            return "{}: {}".format(self.error, self.error_description)
+            return f"{self.error}: {self.error_description}"
         return self.error
 
 
diff --git a/synapse/handlers/federation.py b/synapse/handlers/federation.py
index 991ec9919a95..22024c86565e 100644
--- a/synapse/handlers/federation.py
+++ b/synapse/handlers/federation.py
@@ -735,7 +735,7 @@ async def _get_state_after_missing_prev_event(
         # we need to make sure we re-load from the database to get the rejected
         # state correct.
         fetched_events.update(
-            (await self.store.get_events(missing_desired_events, allow_rejected=True))
+            await self.store.get_events(missing_desired_events, allow_rejected=True)
         )
 
         # check for events which were in the wrong room.
diff --git a/synapse/handlers/identity.py b/synapse/handlers/identity.py
index 33d16fbf9c36..0961dec5ab5c 100644
--- a/synapse/handlers/identity.py
+++ b/synapse/handlers/identity.py
@@ -302,7 +302,7 @@ async def try_unbind_threepid_with_id_server(
             )
 
         url = "https://%s/_matrix/identity/api/v1/3pid/unbind" % (id_server,)
-        url_bytes = "/_matrix/identity/api/v1/3pid/unbind".encode("ascii")
+        url_bytes = b"/_matrix/identity/api/v1/3pid/unbind"
 
         content = {
             "mxid": mxid,
@@ -695,7 +695,7 @@ async def _lookup_3pid_v1(
                 return data["mxid"]
         except RequestTimedOutError:
             raise SynapseError(500, "Timed out contacting identity server")
-        except IOError as e:
+        except OSError as e:
             logger.warning("Error from v1 identity server lookup: %s" % (e,))
 
         return None
diff --git a/synapse/handlers/oidc.py b/synapse/handlers/oidc.py
index ee6e41c0e4d9..845c7b4c2099 100644
--- a/synapse/handlers/oidc.py
+++ b/synapse/handlers/oidc.py
@@ -72,26 +72,26 @@
     (b"oidc_session_no_samesite", b"HttpOnly"),
 ]
 
+
 #: A token exchanged from the token endpoint, as per RFC6749 sec 5.1. and
 #: OpenID.Core sec 3.1.3.3.
-Token = TypedDict(
-    "Token",
-    {
-        "access_token": str,
-        "token_type": str,
-        "id_token": Optional[str],
-        "refresh_token": Optional[str],
-        "expires_in": int,
-        "scope": Optional[str],
-    },
-)
+class Token(TypedDict):
+    access_token: str
+    token_type: str
+    id_token: Optional[str]
+    refresh_token: Optional[str]
+    expires_in: int
+    scope: Optional[str]
+
 
 #: A JWK, as per RFC7517 sec 4. The type could be more precise than that, but
 #: there is no real point of doing this in our case.
 JWK = Dict[str, str]
 
+
 #: A JWK Set, as per RFC7517 sec 5.
-JWKS = TypedDict("JWKS", {"keys": List[JWK]})
+class JWKS(TypedDict):
+    keys: List[JWK]
 
 
 class OidcHandler:
@@ -255,7 +255,7 @@ def __init__(self, error, error_description=None):
 
     def __str__(self):
         if self.error_description:
-            return "{}: {}".format(self.error, self.error_description)
+            return f"{self.error}: {self.error_description}"
         return self.error
 
 
@@ -639,7 +639,7 @@ async def _exchange_code(self, code: str) -> Token:
             )
             logger.warning(description)
             # Body was still valid JSON. Might be useful to log it for debugging.
-            logger.warning("Code exchange response: {resp!r}".format(resp=resp))
+            logger.warning("Code exchange response: %r", resp)
             raise OidcError("server_error", description)
 
         return resp
@@ -1217,10 +1217,12 @@ class OidcSessionData:
     ui_auth_session_id = attr.ib(type=str)
 
 
-UserAttributeDict = TypedDict(
-    "UserAttributeDict",
-    {"localpart": Optional[str], "display_name": Optional[str], "emails": List[str]},
-)
+class UserAttributeDict(TypedDict):
+    localpart: Optional[str]
+    display_name: Optional[str]
+    emails: List[str]
+
+
 C = TypeVar("C")
 
 
diff --git a/synapse/handlers/register.py b/synapse/handlers/register.py
index 26ef0161796a..6a826a169f19 100644
--- a/synapse/handlers/register.py
+++ b/synapse/handlers/register.py
@@ -55,15 +55,12 @@
     ["guest", "auth_provider"],
 )
 
-LoginDict = TypedDict(
-    "LoginDict",
-    {
-        "device_id": str,
-        "access_token": str,
-        "valid_until_ms": Optional[int],
-        "refresh_token": Optional[str],
-    },
-)
+
+class LoginDict(TypedDict):
+    device_id: str
+    access_token: str
+    valid_until_ms: Optional[int]
+    refresh_token: Optional[str]
 
 
 class RegistrationHandler(BaseHandler):
diff --git a/synapse/handlers/saml.py b/synapse/handlers/saml.py
index 80ba65b9e019..e0c9952cd0fb 100644
--- a/synapse/handlers/saml.py
+++ b/synapse/handlers/saml.py
@@ -372,7 +372,7 @@ def expire_sessions(self):
 
 
 DOT_REPLACE_PATTERN = re.compile(
-    ("[^%s]" % (re.escape("".join(mxid_localpart_allowed_characters)),))
+    "[^%s]" % (re.escape("".join(mxid_localpart_allowed_characters)),)
 )
 
 
diff --git a/synapse/handlers/sync.py b/synapse/handlers/sync.py
index b9a036105959..a20e10438164 100644
--- a/synapse/handlers/sync.py
+++ b/synapse/handlers/sync.py
@@ -1599,7 +1599,7 @@ async def _get_rooms_changed(
             logger.debug(
                 "Membership changes in %s: [%s]",
                 room_id,
-                ", ".join(("%s (%s)" % (e.event_id, e.membership) for e in events)),
+                ", ".join("%s (%s)" % (e.event_id, e.membership) for e in events),
             )
 
             non_joins = [e for e in events if e.membership != Membership.JOIN]
diff --git a/synapse/http/proxyagent.py b/synapse/http/proxyagent.py
index 7dfae8b786b9..6cfb00732ed9 100644
--- a/synapse/http/proxyagent.py
+++ b/synapse/http/proxyagent.py
@@ -171,7 +171,7 @@ def request(self, method, uri, headers=None, bodyProducer=None):
         """
         uri = uri.strip()
         if not _VALID_URI.match(uri):
-            raise ValueError("Invalid URI {!r}".format(uri))
+            raise ValueError(f"Invalid URI {uri!r}")
 
         parsed_uri = URI.fromBytes(uri)
         pool_key = (parsed_uri.scheme, parsed_uri.host, parsed_uri.port)
diff --git a/synapse/http/site.py b/synapse/http/site.py
index 40754b7bea7e..b249389f8c3c 100644
--- a/synapse/http/site.py
+++ b/synapse/http/site.py
@@ -384,7 +384,7 @@ def _finished_processing(self):
         # authenticated (e.g. and admin is puppetting a user) then we log both.
         requester, authenticated_entity = self.get_authenticated_entity()
         if authenticated_entity:
-            requester = "{}.{}".format(authenticated_entity, requester)
+            requester = f"{authenticated_entity}.{requester}"
 
         self.site.access_logger.log(
             log_level,
diff --git a/synapse/logging/opentracing.py b/synapse/logging/opentracing.py
index 140ed711e373..0a2302c494af 100644
--- a/synapse/logging/opentracing.py
+++ b/synapse/logging/opentracing.py
@@ -374,7 +374,7 @@ def init_tracer(hs: "HomeServer"):
 
     config = JaegerConfig(
         config=hs.config.jaeger_config,
-        service_name="{} {}".format(hs.config.server_name, hs.get_instance_name()),
+        service_name=f"{hs.config.server_name} {hs.get_instance_name()}",
         scope_manager=LogContextScopeManager(hs.config),
         metrics_factory=PrometheusMetricsFactory(),
     )
diff --git a/synapse/metrics/_exposition.py b/synapse/metrics/_exposition.py
index 8002be56e0e8..27f46c578d3e 100644
--- a/synapse/metrics/_exposition.py
+++ b/synapse/metrics/_exposition.py
@@ -34,7 +34,7 @@
 
 from synapse.util import caches
 
-CONTENT_TYPE_LATEST = str("text/plain; version=0.0.4; charset=utf-8")
+CONTENT_TYPE_LATEST = "text/plain; version=0.0.4; charset=utf-8"
 
 
 INF = float("inf")
@@ -55,8 +55,8 @@ def floatToGoString(d):
         # Go switches to exponents sooner than Python.
         # We only need to care about positive values for le/quantile.
         if d > 0 and dot > 6:
-            mantissa = "{0}.{1}{2}".format(s[0], s[1:dot], s[dot + 1 :]).rstrip("0.")
-            return "{0}e+0{1}".format(mantissa, dot - 1)
+            mantissa = f"{s[0]}.{s[1:dot]}{s[dot + 1 :]}".rstrip("0.")
+            return f"{mantissa}e+0{dot - 1}"
         return s
 
 
@@ -65,7 +65,7 @@ def sample_line(line, name):
         labelstr = "{{{0}}}".format(
             ",".join(
                 [
-                    '{0}="{1}"'.format(
+                    '{}="{}"'.format(
                         k,
                         v.replace("\\", r"\\").replace("\n", r"\n").replace('"', r"\""),
                     )
@@ -78,10 +78,8 @@ def sample_line(line, name):
     timestamp = ""
     if line.timestamp is not None:
         # Convert to milliseconds.
-        timestamp = " {0:d}".format(int(float(line.timestamp) * 1000))
-    return "{0}{1} {2}{3}\n".format(
-        name, labelstr, floatToGoString(line.value), timestamp
-    )
+        timestamp = f" {int(float(line.timestamp) * 1000):d}"
+    return "{}{} {}{}\n".format(name, labelstr, floatToGoString(line.value), timestamp)
 
 
 def generate_latest(registry, emit_help=False):
@@ -118,12 +116,12 @@ def generate_latest(registry, emit_help=False):
         # Output in the old format for compatibility.
         if emit_help:
             output.append(
-                "# HELP {0} {1}\n".format(
+                "# HELP {} {}\n".format(
                     mname,
                     metric.documentation.replace("\\", r"\\").replace("\n", r"\n"),
                 )
             )
-        output.append("# TYPE {0} {1}\n".format(mname, mtype))
+        output.append(f"# TYPE {mname} {mtype}\n")
 
         om_samples = {}  # type: Dict[str, List[str]]
         for s in metric.samples:
@@ -143,13 +141,13 @@ def generate_latest(registry, emit_help=False):
         for suffix, lines in sorted(om_samples.items()):
             if emit_help:
                 output.append(
-                    "# HELP {0}{1} {2}\n".format(
+                    "# HELP {}{} {}\n".format(
                         metric.name,
                         suffix,
                         metric.documentation.replace("\\", r"\\").replace("\n", r"\n"),
                     )
                 )
-            output.append("# TYPE {0}{1} gauge\n".format(metric.name, suffix))
+            output.append(f"# TYPE {metric.name}{suffix} gauge\n")
             output.extend(lines)
 
         # Get rid of the weird colon things while we're at it
@@ -163,12 +161,12 @@ def generate_latest(registry, emit_help=False):
         # Also output in the new format, if it's different.
         if emit_help:
             output.append(
-                "# HELP {0} {1}\n".format(
+                "# HELP {} {}\n".format(
                     mnewname,
                     metric.documentation.replace("\\", r"\\").replace("\n", r"\n"),
                 )
             )
-        output.append("# TYPE {0} {1}\n".format(mnewname, mtype))
+        output.append(f"# TYPE {mnewname} {mtype}\n")
 
         for s in metric.samples:
             # Get rid of the OpenMetrics specific samples (we should already have
diff --git a/synapse/metrics/background_process_metrics.py b/synapse/metrics/background_process_metrics.py
index de96ca08212a..616bfab77bb3 100644
--- a/synapse/metrics/background_process_metrics.py
+++ b/synapse/metrics/background_process_metrics.py
@@ -137,8 +137,7 @@ def collect(self):
             _background_process_db_txn_duration,
             _background_process_db_sched_duration,
         ):
-            for r in m.collect():
-                yield r
+            yield from m.collect()
 
 
 REGISTRY.register(_Collector())
diff --git a/synapse/rest/client/v1/login.py b/synapse/rest/client/v1/login.py
index cbcb60fe314f..4323712448e1 100644
--- a/synapse/rest/client/v1/login.py
+++ b/synapse/rest/client/v1/login.py
@@ -44,19 +44,14 @@
 logger = logging.getLogger(__name__)
 
 
-LoginResponse = TypedDict(
-    "LoginResponse",
-    {
-        "user_id": str,
-        "access_token": str,
-        "home_server": str,
-        "expires_in_ms": Optional[int],
-        "refresh_token": Optional[str],
-        "device_id": str,
-        "well_known": Optional[Dict[str, Any]],
-    },
-    total=False,
-)
+class LoginResponse(TypedDict, total=False):
+    user_id: str
+    access_token: str
+    home_server: str
+    expires_in_ms: Optional[int]
+    refresh_token: Optional[str]
+    device_id: str
+    well_known: Optional[Dict[str, Any]]
 
 
 class LoginRestServlet(RestServlet):
@@ -150,9 +145,7 @@ def on_GET(self, request: SynapseRequest):
             # login flow types returned.
             flows.append({"type": LoginRestServlet.TOKEN_TYPE})
 
-        flows.extend(
-            ({"type": t} for t in self.auth_handler.get_supported_login_types())
-        )
+        flows.extend({"type": t} for t in self.auth_handler.get_supported_login_types())
 
         flows.append({"type": LoginRestServlet.APPSERVICE_TYPE})
 
diff --git a/synapse/rest/media/v1/__init__.py b/synapse/rest/media/v1/__init__.py
index d20186bbd095..3dd16d4bb542 100644
--- a/synapse/rest/media/v1/__init__.py
+++ b/synapse/rest/media/v1/__init__.py
@@ -17,7 +17,7 @@
 # check for JPEG support.
 try:
     PIL.Image._getdecoder("rgb", "jpeg", None)
-except IOError as e:
+except OSError as e:
     if str(e).startswith("decoder jpeg not available"):
         raise Exception(
             "FATAL: jpeg codec not supported. Install pillow correctly! "
@@ -32,7 +32,7 @@
 # check for PNG support.
 try:
     PIL.Image._getdecoder("rgb", "zip", None)
-except IOError as e:
+except OSError as e:
     if str(e).startswith("decoder zip not available"):
         raise Exception(
             "FATAL: zip codec not supported. Install pillow correctly! "
diff --git a/synapse/storage/database.py b/synapse/storage/database.py
index 33c42cf95a88..dba4e4b16cb4 100644
--- a/synapse/storage/database.py
+++ b/synapse/storage/database.py
@@ -907,7 +907,7 @@ def simple_insert_many_txn(
         # The sort is to ensure that we don't rely on dictionary iteration
         # order.
         keys, vals = zip(
-            *[zip(*(sorted(i.items(), key=lambda kv: kv[0]))) for i in values if i]
+            *(zip(*(sorted(i.items(), key=lambda kv: kv[0]))) for i in values if i)
         )
 
         for k in keys:
diff --git a/synapse/storage/databases/main/deviceinbox.py b/synapse/storage/databases/main/deviceinbox.py
index 50e7ddd7355b..c55508867d07 100644
--- a/synapse/storage/databases/main/deviceinbox.py
+++ b/synapse/storage/databases/main/deviceinbox.py
@@ -203,9 +203,7 @@ def delete_messages_for_device_txn(txn):
             "delete_messages_for_device", delete_messages_for_device_txn
         )
 
-        log_kv(
-            {"message": "deleted {} messages for device".format(count), "count": count}
-        )
+        log_kv({"message": f"deleted {count} messages for device", "count": count})
 
         # Update the cache, ensuring that we only ever increase the value
         last_deleted_stream_id = self._last_device_delete_cache.get(
diff --git a/synapse/storage/databases/main/group_server.py b/synapse/storage/databases/main/group_server.py
index 66ad363bfb29..e70d3649ff5a 100644
--- a/synapse/storage/databases/main/group_server.py
+++ b/synapse/storage/databases/main/group_server.py
@@ -27,8 +27,11 @@
 _DEFAULT_CATEGORY_ID = ""
 _DEFAULT_ROLE_ID = ""
 
+
 # A room in a group.
-_RoomInGroup = TypedDict("_RoomInGroup", {"room_id": str, "is_public": bool})
+class _RoomInGroup(TypedDict):
+    room_id: str
+    is_public: bool
 
 
 class GroupServerWorkerStore(SQLBaseStore):
@@ -92,6 +95,7 @@ async def get_rooms_in_group(
               "is_public": False                    # Whether this is a public room or not
             }
         """
+
         # TODO: Pagination
 
         def _get_rooms_in_group_txn(txn):
diff --git a/synapse/storage/databases/main/roommember.py b/synapse/storage/databases/main/roommember.py
index 2796354a1f58..23dde5eb9365 100644
--- a/synapse/storage/databases/main/roommember.py
+++ b/synapse/storage/databases/main/roommember.py
@@ -649,7 +649,7 @@ async def _get_joined_users_from_context(
             event_to_memberships = await self._get_joined_profiles_from_event_ids(
                 missing_member_event_ids
             )
-            users_in_room.update((row for row in event_to_memberships.values() if row))
+            users_in_room.update(row for row in event_to_memberships.values() if row)
 
         if event is not None and event.type == EventTypes.Member:
             if event.membership == Membership.JOIN:
diff --git a/synapse/storage/prepare_database.py b/synapse/storage/prepare_database.py
index 683e5e3b90b4..2567dbb8d074 100644
--- a/synapse/storage/prepare_database.py
+++ b/synapse/storage/prepare_database.py
@@ -639,7 +639,7 @@ def get_statements(f: Iterable[str]) -> Generator[str, None, None]:
 
 
 def executescript(txn: Cursor, schema_path: str) -> None:
-    with open(schema_path, "r") as f:
+    with open(schema_path) as f:
         execute_statements_from_stream(txn, f)
 
 
diff --git a/synapse/types.py b/synapse/types.py
index 8d2fa00f7140..f9ef45dad24d 100644
--- a/synapse/types.py
+++ b/synapse/types.py
@@ -577,10 +577,10 @@ async def to_string(self, store: "DataStore") -> str:
             entries = []
             for name, pos in self.instance_map.items():
                 instance_id = await store.get_id_for_instance(name)
-                entries.append("{}.{}".format(instance_id, pos))
+                entries.append(f"{instance_id}.{pos}")
 
             encoded_map = "~".join(entries)
-            return "m{}~{}".format(self.stream, encoded_map)
+            return f"m{self.stream}~{encoded_map}"
         else:
             return "s%d" % (self.stream,)
 
diff --git a/synapse/util/caches/lrucache.py b/synapse/util/caches/lrucache.py
index 4b9d0433fffc..1614a656d4cb 100644
--- a/synapse/util/caches/lrucache.py
+++ b/synapse/util/caches/lrucache.py
@@ -90,8 +90,7 @@ def enumerate_leaves(node, depth):
         yield node
     else:
         for n in node.values():
-            for m in enumerate_leaves(n, depth - 1):
-                yield m
+            yield from enumerate_leaves(n, depth - 1)
 
 
 P = TypeVar("P")
diff --git a/synapse/util/caches/treecache.py b/synapse/util/caches/treecache.py
index a6df81ebffdc..4138931e7bc1 100644
--- a/synapse/util/caches/treecache.py
+++ b/synapse/util/caches/treecache.py
@@ -138,7 +138,6 @@ def iterate_tree_cache_entry(d):
     """
     if isinstance(d, TreeCacheNode):
         for value_d in d.values():
-            for value in iterate_tree_cache_entry(value_d):
-                yield value
+            yield from iterate_tree_cache_entry(value_d)
     else:
         yield d
diff --git a/synapse/util/daemonize.py b/synapse/util/daemonize.py
index 31b24dd18882..d8532411c2c5 100644
--- a/synapse/util/daemonize.py
+++ b/synapse/util/daemonize.py
@@ -31,13 +31,13 @@ def daemonize_process(pid_file: str, logger: logging.Logger, chdir: str = "/") -
     # If pidfile already exists, we should read pid from there; to overwrite it, if
     # locking will fail, because locking attempt somehow purges the file contents.
     if os.path.isfile(pid_file):
-        with open(pid_file, "r") as pid_fh:
+        with open(pid_file) as pid_fh:
             old_pid = pid_fh.read()
 
     # Create a lockfile so that only one instance of this daemon is running at any time.
     try:
         lock_fh = open(pid_file, "w")
-    except IOError:
+    except OSError:
         print("Unable to create the pidfile.")
         sys.exit(1)
 
@@ -45,7 +45,7 @@ def daemonize_process(pid_file: str, logger: logging.Logger, chdir: str = "/") -
         # Try to get an exclusive lock on the file. This will fail if another process
         # has the file locked.
         fcntl.flock(lock_fh, fcntl.LOCK_EX | fcntl.LOCK_NB)
-    except IOError:
+    except OSError:
         print("Unable to lock on the pidfile.")
         # We need to overwrite the pidfile if we got here.
         #
@@ -113,7 +113,7 @@ def excepthook(type_, value, traceback):
     try:
         lock_fh.write("%s" % (os.getpid()))
         lock_fh.flush()
-    except IOError:
+    except OSError:
         logger.error("Unable to write pid to the pidfile.")
         print("Unable to write pid to the pidfile.")
         sys.exit(1)
diff --git a/synapse/visibility.py b/synapse/visibility.py
index 490fb26e8114..b03fb7da9681 100644
--- a/synapse/visibility.py
+++ b/synapse/visibility.py
@@ -96,7 +96,7 @@ async def filter_events_for_client(
         if isinstance(ignored_users_dict, dict):
             ignore_list = frozenset(ignored_users_dict.keys())
 
-    erased_senders = await storage.main.are_users_erased((e.sender for e in events))
+    erased_senders = await storage.main.are_users_erased(e.sender for e in events)
 
     if filter_send_to_client:
         room_ids = {e.room_id for e in events}
@@ -353,7 +353,7 @@ def check_event_is_visible(event: EventBase, state: StateMap[EventBase]) -> bool
         )
 
     if not check_history_visibility_only:
-        erased_senders = await storage.main.are_users_erased((e.sender for e in events))
+        erased_senders = await storage.main.are_users_erased(e.sender for e in events)
     else:
         # We don't want to check whether users are erased, which is equivalent
         # to no users having been erased.