diff --git a/cmake/CMakeLists.txt b/cmake/CMakeLists.txt
index 5796db03fed7c..e82219a0aff64 100644
--- a/cmake/CMakeLists.txt
+++ b/cmake/CMakeLists.txt
@@ -114,7 +114,9 @@ option(onnxruntime_ENABLE_LTO "Enable link time optimization" OFF)
 option(onnxruntime_CROSS_COMPILING "Cross compiling onnx runtime" OFF)
 option(onnxruntime_GCOV_COVERAGE "Compile with options necessary to run code coverage" OFF)
 option(onnxruntime_DONT_VECTORIZE "Do not vectorize operations in Eigen" OFF)
-option(onnxruntime_USE_FULL_PROTOBUF "Link to libprotobuf instead of libprotobuf-lite when this option is ON" OFF)
+
+#It's preferred to turn it OFF when onnxruntime is dynamically linked to PROTOBUF. But Tensort always required the full version of protobuf.
+cmake_dependent_option(onnxruntime_USE_FULL_PROTOBUF "Link to libprotobuf instead of libprotobuf-lite when this option is ON" OFF "NOT onnxruntime_USE_TENSORRT" ON)
 option(tensorflow_C_PACKAGE_PATH "Path to tensorflow C package installation dir")
 option(onnxruntime_ENABLE_LANGUAGE_INTEROP_OPS "Enable operator implemented in language other than cpp" OFF)
 option(onnxruntime_DEBUG_NODE_INPUTS_OUTPUTS "Dump debug information about node inputs and outputs when executing the model." OFF)
diff --git a/tools/ci_build/build.py b/tools/ci_build/build.py
index 76cda428cabe3..11f0c53942481 100644
--- a/tools/ci_build/build.py
+++ b/tools/ci_build/build.py
@@ -1187,9 +1187,9 @@ def generate_build_tree(
             "-Donnxruntime_USE_OPENVINO_AUTO=" + ("ON" if args.use_openvino.startswith("AUTO") else "OFF"),
         ]
 
-    # VitisAI and OpenVINO providers currently only support
+    # TensorRT and OpenVINO providers currently only support
     # full_protobuf option.
-    if args.use_full_protobuf or args.use_openvino or args.use_vitisai or args.gen_doc:
+    if args.use_full_protobuf or args.use_tensorrt or args.use_openvino or args.use_vitisai or args.gen_doc:
         cmake_args += ["-Donnxruntime_USE_FULL_PROTOBUF=ON", "-DProtobuf_USE_STATIC_LIBS=ON"]
 
     if args.use_tvm and args.llvm_path is not None: