diff --git a/doc/source/whatsnew/v0.17.1.txt b/doc/source/whatsnew/v0.17.1.txt
index 6d4b61bb97f22..c5ae364e4a528 100755
--- a/doc/source/whatsnew/v0.17.1.txt
+++ b/doc/source/whatsnew/v0.17.1.txt
@@ -64,8 +64,8 @@ Bug Fixes
 
 - Bug in ``HDFStore.select`` when comparing with a numpy scalar in a where clause (:issue:`11283`)
 
-- Bug in tz-conversions with an ambiguous time and ``.dt`` accessors (:issues:`11295`)
-
+- Bug in tz-conversions with an ambiguous time and ``.dt`` accessors (:issue:`11295`)
+- Bug in comparisons of Series vs list-likes (:issue:`11339`)
 
 - Bug in list-like indexing with a mixed-integer Index (:issue:`11320`)
 
diff --git a/pandas/core/ops.py b/pandas/core/ops.py
index 5b3d6069f17ec..bf331ff1b781c 100644
--- a/pandas/core/ops.py
+++ b/pandas/core/ops.py
@@ -720,7 +720,7 @@ def wrapper(self, other, axis=None):
             res = op(self.values, other)
         else:
             values = self.get_values()
-            if is_list_like(other):
+            if isinstance(other, (list, np.ndarray)):
                 other = np.asarray(other)
 
             res = na_op(values, other)
diff --git a/pandas/tests/test_series.py b/pandas/tests/test_series.py
index 9c86c3f894c67..f8d2c8bfd0dfb 100644
--- a/pandas/tests/test_series.py
+++ b/pandas/tests/test_series.py
@@ -4269,6 +4269,43 @@ def test_object_comparisons(self):
         expected = -(s == 'a')
         assert_series_equal(result, expected)
 
+    def test_comparison_tuples(self):
+        # GH11339
+        # comparisons vs tuple
+        s = Series([(1,1),(1,2)])
+
+        result = s == (1,2)
+        expected = Series([False,True])
+        assert_series_equal(result, expected)
+
+        result = s != (1,2)
+        expected = Series([True, False])
+        assert_series_equal(result, expected)
+
+        result = s == (0,0)
+        expected = Series([False, False])
+        assert_series_equal(result, expected)
+
+        result = s != (0,0)
+        expected = Series([True, True])
+        assert_series_equal(result, expected)
+
+        s = Series([(1,1),(1,1)])
+
+        result = s == (1,1)
+        expected = Series([True, True])
+        assert_series_equal(result, expected)
+
+        result = s != (1,1)
+        expected = Series([False, False])
+        assert_series_equal(result, expected)
+
+        s = Series([frozenset([1]),frozenset([1,2])])
+
+        result = s == frozenset([1])
+        expected = Series([True, False])
+        assert_series_equal(result, expected)
+
     def test_comparison_operators_with_nas(self):
         s = Series(bdate_range('1/1/2000', periods=10), dtype=object)
         s[::2] = np.nan