diff --git a/app/react-native/scripts/__snapshots__/loader.test.js.snap b/app/react-native/scripts/__snapshots__/loader.test.js.snap
index 5906ee65d4..c0680bd44f 100644
--- a/app/react-native/scripts/__snapshots__/loader.test.js.snap
+++ b/app/react-native/scripts/__snapshots__/loader.test.js.snap
@@ -1,5 +1,40 @@
 // Jest Snapshot v1, https://goo.gl/fbAQLP
 
+exports[`loader writeRequires when there is a story glob and exclude paths globs writes the story imports 1`] = `
+"
+      /* do not change this file, it is auto generated by storybook. */
+
+      import { configure, addDecorator, addParameters, addArgsEnhancer } from '@storybook/react-native';
+
+      import \\"@storybook/addon-ondevice-notes/register\\";
+import \\"@storybook/addon-ondevice-controls/register\\";
+import \\"@storybook/addon-ondevice-backgrounds/register\\";
+import \\"@storybook/addon-ondevice-actions/register\\";
+
+      import { argsEnhancers } from \\"@storybook/addon-actions/dist/modern/preset/addArgs\\"
+
+      
+  import { decorators, parameters } from './preview';
+
+  if (decorators) {
+    decorators.forEach((decorator) => addDecorator(decorator));
+  }
+
+  if (parameters) {
+    addParameters(parameters);
+  }
+
+
+      argsEnhancers.forEach(enhancer => addArgsEnhancer(enhancer))
+
+      const getStories=() => {
+        return [require(\\"include-components/FakeStory.stories.tsx\\")];
+      }
+
+      configure(getStories, module, false)
+  "
+`;
+
 exports[`loader writeRequires when there is a story glob writes the story imports 1`] = `
 "
       /* do not change this file, it is auto generated by storybook. */
diff --git a/app/react-native/scripts/loader.js b/app/react-native/scripts/loader.js
index a0711c162e..85b6f71e2c 100644
--- a/app/react-native/scripts/loader.js
+++ b/app/react-native/scripts/loader.js
@@ -17,6 +17,21 @@ const previewImports = `
   }
 `;
 
+function normalizeExcludePaths(paths) {
+  // automatically convert a string to an array of a single string
+  if (typeof paths === 'string') {
+    return [paths];
+  }
+
+  // ensure the paths is an array and if any items exists, they are strings
+  if (Array.isArray(paths) && paths.every((p) => typeof p === 'string')) {
+    return paths;
+  }
+
+  // when the paths aren't a string or an (empty) array of strings, return
+  return undefined;
+}
+
 function requireUncached(module) {
   delete require.cache[require.resolve(module)];
   return require(module);
@@ -36,8 +51,19 @@ function writeRequires({ configPath, absolute = false }) {
   const storybookRequiresLocation = path.resolve(cwd, configPath, 'storybook.requires.js');
 
   const main = getMain({ configPath });
+  const reactNativeOptions = main.reactNativeOptions;
+  const excludePaths = reactNativeOptions && reactNativeOptions.excludePaths;
+  const normalizedExcludePaths = normalizeExcludePaths(excludePaths);
+
   const storyPaths = main.stories.reduce((acc, storyGlob) => {
-    const paths = glob.sync(storyGlob, { cwd: path.resolve(cwd, configPath), absolute });
+    const paths = glob.sync(storyGlob, {
+      cwd: path.resolve(cwd, configPath),
+      absolute,
+      // default to always ignore (exclude) anything in node_modules
+      ignore: normalizedExcludePaths !== undefined
+        ? normalizedExcludePaths
+        : ['**/node_modules'],
+    });
     return [...acc, ...paths];
   }, []);
 
diff --git a/app/react-native/scripts/loader.test.js b/app/react-native/scripts/loader.test.js
index a7f5ada133..ff9e195748 100644
--- a/app/react-native/scripts/loader.test.js
+++ b/app/react-native/scripts/loader.test.js
@@ -86,6 +86,20 @@ describe('loader', () => {
       });
     });
 
+    describe('when there is a story glob and exclude paths globs', () => {
+      it('writes the story imports', () => {
+        writeRequires({ configPath: 'scripts/mocks/exclude-config-files' });
+        expect(pathMock).toEqual(
+          path.resolve(__dirname, 'mocks/exclude-config-files/storybook.requires.js')
+        );
+
+        expect(fileContentMock).toContain('include-components/FakeStory.stories.tsx');
+        expect(fileContentMock).not.toContain('exclude-components/FakeStory.stories.tsx');
+
+        expect(fileContentMock).toMatchSnapshot();
+      });
+    });
+
     describe('when there is no story glob or addons', () => {
       it('writes no story imports or addons', () => {
         writeRequires({ configPath: 'scripts/mocks/blank-config' });
diff --git a/app/react-native/scripts/mocks/exclude-config-files/exclude-components/FakeComponent.tsx b/app/react-native/scripts/mocks/exclude-config-files/exclude-components/FakeComponent.tsx
new file mode 100644
index 0000000000..23915b0493
--- /dev/null
+++ b/app/react-native/scripts/mocks/exclude-config-files/exclude-components/FakeComponent.tsx
@@ -0,0 +1 @@
+export const FakeComponent = () => null;
diff --git a/app/react-native/scripts/mocks/exclude-config-files/exclude-components/FakeStory.stories.tsx b/app/react-native/scripts/mocks/exclude-config-files/exclude-components/FakeStory.stories.tsx
new file mode 100644
index 0000000000..2176b3bf74
--- /dev/null
+++ b/app/react-native/scripts/mocks/exclude-config-files/exclude-components/FakeStory.stories.tsx
@@ -0,0 +1,10 @@
+import { FakeComponentExcluded } from './FakeComponent';
+
+export default {
+  title: 'components/FakeComponentExcluded',
+  component: FakeComponentExcluded,
+};
+
+export const Basic = {
+  args: {},
+};
diff --git a/app/react-native/scripts/mocks/exclude-config-files/include-components/FakeComponent.tsx b/app/react-native/scripts/mocks/exclude-config-files/include-components/FakeComponent.tsx
new file mode 100644
index 0000000000..23915b0493
--- /dev/null
+++ b/app/react-native/scripts/mocks/exclude-config-files/include-components/FakeComponent.tsx
@@ -0,0 +1 @@
+export const FakeComponent = () => null;
diff --git a/app/react-native/scripts/mocks/exclude-config-files/include-components/FakeStory.stories.tsx b/app/react-native/scripts/mocks/exclude-config-files/include-components/FakeStory.stories.tsx
new file mode 100644
index 0000000000..ca6d412600
--- /dev/null
+++ b/app/react-native/scripts/mocks/exclude-config-files/include-components/FakeStory.stories.tsx
@@ -0,0 +1,10 @@
+import { FakeComponent } from './FakeComponent';
+
+export default {
+  title: 'components/FakeComponent',
+  component: FakeComponent,
+};
+
+export const Basic = {
+  args: {},
+};
diff --git a/app/react-native/scripts/mocks/exclude-config-files/main.js b/app/react-native/scripts/mocks/exclude-config-files/main.js
new file mode 100644
index 0000000000..34b0ea2304
--- /dev/null
+++ b/app/react-native/scripts/mocks/exclude-config-files/main.js
@@ -0,0 +1,12 @@
+module.exports = {
+  stories: ['**/*.stories.tsx'],
+  reactNativeOptions: {
+    excludePaths: '**/exclude-components/**',
+  },
+  addons: [
+    '@storybook/addon-ondevice-notes',
+    '@storybook/addon-ondevice-controls',
+    '@storybook/addon-ondevice-backgrounds',
+    '@storybook/addon-ondevice-actions',
+  ],
+};
diff --git a/app/react-native/scripts/mocks/exclude-config-files/preview.js b/app/react-native/scripts/mocks/exclude-config-files/preview.js
new file mode 100644
index 0000000000..13bad13073
--- /dev/null
+++ b/app/react-native/scripts/mocks/exclude-config-files/preview.js
@@ -0,0 +1,24 @@
+import React from 'react';
+import { View, StyleSheet } from 'react-native';
+import { withBackgrounds } from '@storybook/addon-ondevice-backgrounds';
+
+export const decorators = [
+  (StoryFn) => (
+    <View style={styles.container}>
+      <StoryFn />
+    </View>
+  ),
+  withBackgrounds,
+];
+export const parameters = {
+  my_param: 'anything',
+  backgrounds: [
+    { name: 'plain', value: 'white', default: true },
+    { name: 'warm', value: 'hotpink' },
+    { name: 'cool', value: 'deepskyblue' },
+  ],
+};
+
+const styles = StyleSheet.create({
+  container: { padding: 8, flex: 1 },
+});