diff --git a/CHANGELOG.md b/CHANGELOG.md
index 055d9914cf63..b889faa98471 100644
--- a/CHANGELOG.md
+++ b/CHANGELOG.md
@@ -19,6 +19,7 @@
 - `[jest-config]` Add config validation for `projects` option ([#13565](https://github.com/facebook/jest/pull/13565))
 - `[jest-mock]` Treat cjs modules as objects so they can be mocked ([#13513](https://github.com/facebook/jest/pull/13513))
 - `[jest-worker]` Throw an error instead of hanging when jest workers terminate unexpectedly ([#13566](https://github.com/facebook/jest/pull/13566))
+- `[jest-worker]` Ignore IPC messages not intended for Jest ([#13543](https://github.com/facebook/jest/pull/13543))
 
 ### Chore & Maintenance
 
diff --git a/packages/jest-worker/src/workers/ChildProcessWorker.ts b/packages/jest-worker/src/workers/ChildProcessWorker.ts
index 691bbb6edefd..9e0832c1e7fa 100644
--- a/packages/jest-worker/src/workers/ChildProcessWorker.ts
+++ b/packages/jest-worker/src/workers/ChildProcessWorker.ts
@@ -255,6 +255,9 @@ export default class ChildProcessWorker
   }
 
   private _onMessage(response: ParentMessage) {
+    // Ignore messages not intended for us
+    if (!Array.isArray(response)) return;
+
     // TODO: Add appropriate type check
     let error: any;
 
@@ -311,7 +314,8 @@ export default class ChildProcessWorker
         break;
 
       default:
-        throw new TypeError(`Unexpected response from worker: ${response[0]}`);
+        // Ignore messages not intended for us
+        break;
     }
   }
 
diff --git a/packages/jest-worker/src/workers/NodeThreadsWorker.ts b/packages/jest-worker/src/workers/NodeThreadsWorker.ts
index 2acf0054ae5d..3a9f86a46be0 100644
--- a/packages/jest-worker/src/workers/NodeThreadsWorker.ts
+++ b/packages/jest-worker/src/workers/NodeThreadsWorker.ts
@@ -170,6 +170,9 @@ export default class ExperimentalWorker
   }
 
   private _onMessage(response: ParentMessage) {
+    // Ignore messages not intended for us
+    if (!Array.isArray(response)) return;
+
     let error;
 
     switch (response[0]) {
@@ -227,7 +230,8 @@ export default class ExperimentalWorker
         break;
 
       default:
-        throw new TypeError(`Unexpected response from worker: ${response[0]}`);
+        // Ignore messages not intended for us
+        break;
     }
   }
 
diff --git a/packages/jest-worker/src/workers/__tests__/ChildProcessWorker.test.ts b/packages/jest-worker/src/workers/__tests__/ChildProcessWorker.test.ts
index 9e6b513cb22f..90c9e1b07bdd 100644
--- a/packages/jest-worker/src/workers/__tests__/ChildProcessWorker.test.ts
+++ b/packages/jest-worker/src/workers/__tests__/ChildProcessWorker.test.ts
@@ -363,7 +363,7 @@ it('creates error instances for known errors', () => {
   expect(callback3.mock.calls[0][0]).toBe(412);
 });
 
-it('throws when the child process returns a strange message', () => {
+it('does not throw when the child process returns a strange message', () => {
   const worker = new Worker({
     forkOptions: {},
     maxRetries: 3,
@@ -378,9 +378,14 @@ it('throws when the child process returns a strange message', () => {
   );
 
   // Type 27 does not exist.
-  expect(() => {
-    forkInterface.emit('message', [27]);
-  }).toThrow(TypeError);
+  forkInterface.emit('message', [27]);
+
+  forkInterface.emit('message', 'test');
+  forkInterface.emit('message', {foo: 'bar'});
+  forkInterface.emit('message', 0);
+  forkInterface.emit('message', null);
+  forkInterface.emit('message', Symbol('test'));
+  forkInterface.emit('message', true);
 });
 
 it('does not restart the child if it cleanly exited', () => {
diff --git a/packages/jest-worker/src/workers/__tests__/NodeThreadsWorker.test.ts b/packages/jest-worker/src/workers/__tests__/NodeThreadsWorker.test.ts
index 8d633af24e97..7e0e53dc9d50 100644
--- a/packages/jest-worker/src/workers/__tests__/NodeThreadsWorker.test.ts
+++ b/packages/jest-worker/src/workers/__tests__/NodeThreadsWorker.test.ts
@@ -365,7 +365,7 @@ it('creates error instances for known errors', () => {
   expect(callback3.mock.calls[0][0]).toBe(412);
 });
 
-it('throws when the thread returns a strange message', () => {
+it('does not throw when the thread returns a strange message', () => {
   const worker = new Worker({
     forkOptions: {},
     maxRetries: 3,
@@ -380,10 +380,26 @@ it('throws when the thread returns a strange message', () => {
   );
 
   // Type 27 does not exist.
-  expect(() => {
-    // @ts-expect-error: Testing internal method
-    worker._worker.emit('message', [27]);
-  }).toThrow(TypeError);
+  // @ts-expect-error: Testing internal method
+  worker._worker.emit('message', [27]);
+
+  // @ts-expect-error: Testing internal method
+  worker._worker.emit('message', 'test');
+
+  // @ts-expect-error: Testing internal method
+  worker._worker.emit('message', {foo: 'bar'});
+
+  // @ts-expect-error: Testing internal method
+  worker._worker.emit('message', 0);
+
+  // @ts-expect-error: Testing internal method
+  worker._worker.emit('message', null);
+
+  // @ts-expect-error: Testing internal method
+  worker._worker.emit('message', Symbol('test'));
+
+  // @ts-expect-error: Testing internal method
+  worker._worker.emit('message', true);
 });
 
 it('does not restart the thread if it cleanly exited', () => {