diff --git a/http/http-advanced-reactive/src/main/java/io/quarkus/ts/http/advanced/reactive/GreetingInterface.java b/http/http-advanced-reactive/src/main/java/io/quarkus/ts/http/advanced/reactive/GreetingInterface.java
new file mode 100644
index 000000000..4ededef76
--- /dev/null
+++ b/http/http-advanced-reactive/src/main/java/io/quarkus/ts/http/advanced/reactive/GreetingInterface.java
@@ -0,0 +1,11 @@
+package io.quarkus.ts.http.advanced.reactive;
+
+import jakarta.ws.rs.GET;
+import jakarta.ws.rs.Path;
+
+public interface GreetingInterface {
+
+    @GET
+    @Path("/interface-greeting")
+    String interfaceGreeting();
+}
diff --git a/http/http-advanced-reactive/src/main/java/io/quarkus/ts/http/advanced/reactive/GreetingOptionAndHeadResource.java b/http/http-advanced-reactive/src/main/java/io/quarkus/ts/http/advanced/reactive/GreetingOptionAndHeadResource.java
new file mode 100644
index 000000000..efaf3ed40
--- /dev/null
+++ b/http/http-advanced-reactive/src/main/java/io/quarkus/ts/http/advanced/reactive/GreetingOptionAndHeadResource.java
@@ -0,0 +1,20 @@
+package io.quarkus.ts.http.advanced.reactive;
+
+import jakarta.enterprise.inject.spi.CDI;
+import jakarta.ws.rs.Path;
+
+@Path("/greeting")
+public class GreetingOptionAndHeadResource implements GreetingInterface {
+
+    @Path("/cdi-sub-resource")
+    public GreetingSubResources helloFromSubResource() {
+        return CDI.current()
+                .select(GreetingSubResources.class)
+                .get();
+    }
+
+    @Override
+    public String interfaceGreeting() {
+        return "Greeting from interface";
+    }
+}
diff --git a/http/http-advanced-reactive/src/main/java/io/quarkus/ts/http/advanced/reactive/GreetingSubResources.java b/http/http-advanced-reactive/src/main/java/io/quarkus/ts/http/advanced/reactive/GreetingSubResources.java
new file mode 100644
index 000000000..3b2f4c286
--- /dev/null
+++ b/http/http-advanced-reactive/src/main/java/io/quarkus/ts/http/advanced/reactive/GreetingSubResources.java
@@ -0,0 +1,20 @@
+package io.quarkus.ts.http.advanced.reactive;
+
+import jakarta.enterprise.context.RequestScoped;
+import jakarta.ws.rs.GET;
+import jakarta.ws.rs.POST;
+
+@RequestScoped
+public class GreetingSubResources {
+
+    @GET
+    public String get() {
+        return "Greeting from sub-resource using GET";
+    }
+
+    @POST
+    public String post() {
+        return "Greeting from sub-resource using POST";
+    }
+
+}
diff --git a/http/http-advanced-reactive/src/test/java/io/quarkus/ts/http/advanced/reactive/BaseHttpAdvancedReactiveIT.java b/http/http-advanced-reactive/src/test/java/io/quarkus/ts/http/advanced/reactive/BaseHttpAdvancedReactiveIT.java
index 8cb618574..efb108a15 100644
--- a/http/http-advanced-reactive/src/test/java/io/quarkus/ts/http/advanced/reactive/BaseHttpAdvancedReactiveIT.java
+++ b/http/http-advanced-reactive/src/test/java/io/quarkus/ts/http/advanced/reactive/BaseHttpAdvancedReactiveIT.java
@@ -25,6 +25,8 @@
 import static org.apache.http.HttpStatus.SC_NOT_FOUND;
 import static org.apache.http.HttpStatus.SC_OK;
 import static org.hamcrest.MatcherAssert.assertThat;
+import static org.hamcrest.Matchers.allOf;
+import static org.hamcrest.Matchers.contains;
 import static org.hamcrest.Matchers.containsString;
 import static org.hamcrest.Matchers.equalTo;
 import static org.hamcrest.Matchers.in;
@@ -102,6 +104,64 @@ public void abstractResourceWithPath() {
                 .body(is("Hello from Quarkus REST"));
     }
 
+    @Test
+    @DisplayName("Test Quarkus REST using CDI getting the sub-resource")
+    void cdiSubResourceGetRequest() {
+        getApp().given()
+                .when()
+                .get(GREETING_ENDPOINT + "/cdi-sub-resource")
+                .then()
+                .statusCode(SC_OK)
+                .body(is("Greeting from sub-resource using GET"));
+    }
+
+    @Test
+    @DisplayName("Test Quarkus REST using CDI getting the sub-resource")
+    void cdiSubResourcePostRequest() {
+        getApp().given()
+                .when()
+                .post(GREETING_ENDPOINT + "/cdi-sub-resource")
+                .then()
+                .statusCode(SC_OK)
+                .body(is("Greeting from sub-resource using POST"));
+    }
+
+    @Test
+    @DisplayName("Test Quarkus REST interface resource with @Path")
+    void interfaceResourceWithPath() {
+        getApp().given()
+                .when()
+                .get(GREETING_ENDPOINT + "/interface-greeting")
+                .then()
+                .statusCode(SC_OK)
+                .body(is("Greeting from interface"));
+    }
+
+    @Test
+    @Tag("https://github.com/quarkusio/quarkus/issues/43422")
+    @DisplayName("Test Quarkus REST abstract resource with @Path using OPTION and HEAD request")
+    @DisabledOnNative(reason = "https://github.com/quarkusio/quarkus/issues/42976")
+    void optionAndHeadRequestUsingAbstractResourceWithPath() {
+        testOptionRequest(GREETING_ENDPOINT);
+        testHeadRequest(GREETING_ENDPOINT);
+    }
+
+    @Test
+    @Tag("https://github.com/quarkusio/quarkus/issues/43422")
+    @DisplayName("Test Quarkus REST interface resource with @Path using OPTION and HEAD request")
+    void optionAndHeadRequestUsingInterfaceResourceWithPath() {
+        testOptionRequest(GREETING_ENDPOINT + "/interface-greeting");
+        testHeadRequest(GREETING_ENDPOINT + "/interface-greeting");
+    }
+
+    @Test
+    @Tag("https://github.com/quarkusio/quarkus/issues/43422")
+    @DisplayName("Test Quarkus REST using CDI getting the sub-resource for OPTION and HEAD request")
+    void cdiSubResourceOptionAndHeadRequest() {
+        testOptionRequest(GREETING_ENDPOINT + "/cdi-sub-resource");
+        testHeadRequest(GREETING_ENDPOINT + "/cdi-sub-resource");
+    }
+
     @Test
     @DisplayName("GRPC Server test")
     public void testGrpc() {
@@ -354,6 +414,24 @@ private void testResponseContentType(String acceptedContentType, String expected
                 .then().header(CONTENT_TYPE, expectedContentType);
     }
 
+    private void testOptionRequest(String path) {
+        getApp().given()
+                .when()
+                .options(path)
+                .then()
+                .statusCode(SC_OK)
+                .header(HttpHeaders.ALLOW, allOf(containsString("HEAD"),
+                        containsString("OPTIONS"), containsString("GET")));
+    }
+
+    private void testHeadRequest(String path) {
+        getApp().given()
+                .when()
+                .head(path)
+                .then()
+                .statusCode(SC_OK);
+    }
+
     private ValidatableResponse req99BottlesOfBeer(int bottleNumber, int httpStatusCode) {
         return getApp().given()
                 .get(ROOT_PATH + NinetyNineBottlesOfBeerResource.PATH + "/" + bottleNumber)