diff --git a/CHANGELOG.md b/CHANGELOG.md
index ca581115e507..c18a0f81d40f 100644
--- a/CHANGELOG.md
+++ b/CHANGELOG.md
@@ -92,6 +92,7 @@ Inspired from [Keep a Changelog](https://keepachangelog.com/en/1.0.0/)
 - [BUG][Multiple Datasource] Fix data source filter bug and add tests ([#6152](https://github.com/opensearch-project/OpenSearch-Dashboards/pull/6152))
 - [BUG][Multiple Datasource] Fix obsolete snapshots for test within data source management plugin ([#6185](https://github.com/opensearch-project/OpenSearch-Dashboards/pull/6185))
 - [Workspace] Add base path when parse url in http service ([#6233](https://github.com/opensearch-project/OpenSearch-Dashboards/pull/6233))
+- [Multiple Datasource] Fix sslConfig for multiple datasource to handle when certificateAuthorities is unset ([#6282](https://github.com/opensearch-project/OpenSearch-Dashboards/pull/6282))
 
 ### 🚞 Infrastructure
 
diff --git a/src/plugins/data_source/server/client/client_config.test.ts b/src/plugins/data_source/server/client/client_config.test.ts
index e6aef818f7de..838b8bc882b4 100644
--- a/src/plugins/data_source/server/client/client_config.test.ts
+++ b/src/plugins/data_source/server/client/client_config.test.ts
@@ -46,7 +46,7 @@ describe('parseClientOptions', () => {
         ssl: {
           requestCert: true,
           rejectUnauthorized: false,
-          ca: [],
+          ca: undefined,
         },
       })
     );
@@ -109,4 +109,31 @@ describe('parseClientOptions', () => {
       })
     );
   });
+
+  test('test ssl config with verification mode set to full with no ca list', () => {
+    const config = {
+      enabled: true,
+      ssl: {
+        verificationMode: 'full',
+      },
+      clientPool: {
+        size: 5,
+      },
+    } as DataSourcePluginConfigType;
+    mockReadFileSync.mockReset();
+    mockReadFileSync.mockImplementation((path: string) => `content-of-${path}`);
+    const parsedConfig = parseClientOptions(config, TEST_DATA_SOURCE_ENDPOINT);
+    expect(mockReadFileSync).toHaveBeenCalledTimes(0);
+    mockReadFileSync.mockClear();
+    expect(parsedConfig).toEqual(
+      expect.objectContaining({
+        node: TEST_DATA_SOURCE_ENDPOINT,
+        ssl: {
+          requestCert: true,
+          rejectUnauthorized: true,
+          ca: undefined,
+        },
+      })
+    );
+  });
 });
diff --git a/src/plugins/data_source/server/client/client_config.ts b/src/plugins/data_source/server/client/client_config.ts
index f77986810f1b..0de0ebcf37fa 100644
--- a/src/plugins/data_source/server/client/client_config.ts
+++ b/src/plugins/data_source/server/client/client_config.ts
@@ -56,7 +56,7 @@ export function parseClientOptions(
       config.ssl?.certificateAuthorities
     );
 
-    sslConfig.ca = certificateAuthorities || [];
+    sslConfig.ca = certificateAuthorities;
   }
 
   const clientOptions: ClientOptions = {
diff --git a/src/plugins/data_source/server/legacy/client_config.test.ts b/src/plugins/data_source/server/legacy/client_config.test.ts
index 67445a686f90..b8a6b1664abd 100644
--- a/src/plugins/data_source/server/legacy/client_config.test.ts
+++ b/src/plugins/data_source/server/legacy/client_config.test.ts
@@ -44,7 +44,7 @@ describe('parseClientOptions', () => {
         host: TEST_DATA_SOURCE_ENDPOINT,
         ssl: {
           rejectUnauthorized: false,
-          ca: [],
+          ca: undefined,
         },
       })
     );
@@ -105,4 +105,30 @@ describe('parseClientOptions', () => {
       })
     );
   });
+
+  test('test ssl config with verification mode set to full with no ca list', () => {
+    const config = {
+      enabled: true,
+      ssl: {
+        verificationMode: 'full',
+      },
+      clientPool: {
+        size: 5,
+      },
+    } as DataSourcePluginConfigType;
+    mockReadFileSync.mockReset();
+    mockReadFileSync.mockImplementation((path: string) => `content-of-${path}`);
+    const parsedConfig = parseClientOptions(config, TEST_DATA_SOURCE_ENDPOINT);
+    expect(mockReadFileSync).toHaveBeenCalledTimes(0);
+    mockReadFileSync.mockClear();
+    expect(parsedConfig).toEqual(
+      expect.objectContaining({
+        host: TEST_DATA_SOURCE_ENDPOINT,
+        ssl: {
+          rejectUnauthorized: true,
+          ca: undefined,
+        },
+      })
+    );
+  });
 });
diff --git a/src/plugins/data_source/server/legacy/client_config.ts b/src/plugins/data_source/server/legacy/client_config.ts
index a3704d3ec099..a2dc81d6dc11 100644
--- a/src/plugins/data_source/server/legacy/client_config.ts
+++ b/src/plugins/data_source/server/legacy/client_config.ts
@@ -55,7 +55,7 @@ export function parseClientOptions(
       config.ssl?.certificateAuthorities
     );
 
-    sslConfig.ca = certificateAuthorities || [];
+    sslConfig.ca = certificateAuthorities;
   }
 
   const configOptions: ConfigOptions = {
diff --git a/src/plugins/data_source/server/util/tls_settings_provider.test.ts b/src/plugins/data_source/server/util/tls_settings_provider.test.ts
index 3458ea8e6ccf..6852bb959310 100644
--- a/src/plugins/data_source/server/util/tls_settings_provider.test.ts
+++ b/src/plugins/data_source/server/util/tls_settings_provider.test.ts
@@ -40,7 +40,7 @@ describe('readCertificateAuthorities', () => {
     expect(mockReadFileSync).toHaveBeenCalledTimes(0);
     mockReadFileSync.mockClear();
     expect(certificateAuthorities).toEqual({
-      certificateAuthorities: [],
+      certificateAuthorities: undefined,
     });
   });
 
@@ -52,7 +52,7 @@ describe('readCertificateAuthorities', () => {
     expect(mockReadFileSync).toHaveBeenCalledTimes(0);
     mockReadFileSync.mockClear();
     expect(certificateAuthorities).toEqual({
-      certificateAuthorities: [],
+      certificateAuthorities: undefined,
     });
   });
 });
diff --git a/src/plugins/data_source/server/util/tls_settings_provider.ts b/src/plugins/data_source/server/util/tls_settings_provider.ts
index 0924041a756d..1b86c91c3b6b 100644
--- a/src/plugins/data_source/server/util/tls_settings_provider.ts
+++ b/src/plugins/data_source/server/util/tls_settings_provider.ts
@@ -8,7 +8,7 @@ import { readFileSync } from 'fs';
 export const readCertificateAuthorities = (
   listOfCertificateAuthorities: string | string[] | undefined
 ) => {
-  let certificateAuthorities: string[] | undefined = [];
+  let certificateAuthorities: string[] | undefined;
 
   const addCertificateAuthorities = (ca: string[]) => {
     if (ca && ca.length) {