diff --git a/homeassistant/components/zha/helpers.py b/homeassistant/components/zha/helpers.py
index 0689929699164..f24f6a34a8c22 100644
--- a/homeassistant/components/zha/helpers.py
+++ b/homeassistant/components/zha/helpers.py
@@ -104,7 +104,7 @@
     ATTR_NAME,
     Platform,
 )
-from homeassistant.core import HomeAssistant, callback
+from homeassistant.core import Event, HomeAssistant, callback
 from homeassistant.exceptions import HomeAssistantError
 from homeassistant.helpers import (
     config_validation as cv,
@@ -495,7 +495,7 @@ def __init__(
         self.hass = hass
         self.config_entry = config_entry
         self.gateway = gateway
-        self.device_proxies: dict[str, ZHADeviceProxy] = {}
+        self.device_proxies: dict[EUI64, ZHADeviceProxy] = {}
         self.group_proxies: dict[int, ZHAGroupProxy] = {}
         self._ha_entity_refs: collections.defaultdict[EUI64, list[EntityReference]] = (
             collections.defaultdict(list)
@@ -509,6 +509,12 @@ def __init__(
         self._unsubs: list[Callable[[], None]] = []
         self._unsubs.append(self.gateway.on_all_events(self._handle_event_protocol))
         self._reload_task: asyncio.Task | None = None
+        config_entry.async_on_unload(
+            self.hass.bus.async_listen(
+                er.EVENT_ENTITY_REGISTRY_UPDATED,
+                self._handle_entity_registry_updated,
+            )
+        )
 
     @property
     def ha_entity_refs(self) -> collections.defaultdict[EUI64, list[EntityReference]]:
@@ -532,6 +538,46 @@ def register_entity_reference(
             )
         )
 
+    async def _handle_entity_registry_updated(
+        self, event: Event[er.EventEntityRegistryUpdatedData]
+    ) -> None:
+        """Handle when entity registry updated."""
+        entity_id = event.data["entity_id"]
+        entity_entry: er.RegistryEntry | None = er.async_get(self.hass).async_get(
+            entity_id
+        )
+        if (
+            entity_entry is None
+            or entity_entry.config_entry_id != self.config_entry.entry_id
+            or entity_entry.device_id is None
+        ):
+            return
+        device_entry: dr.DeviceEntry | None = dr.async_get(self.hass).async_get(
+            entity_entry.device_id
+        )
+        assert device_entry
+
+        ieee_address = next(
+            identifier
+            for domain, identifier in device_entry.identifiers
+            if domain == DOMAIN
+        )
+        assert ieee_address
+
+        ieee = EUI64.convert(ieee_address)
+
+        assert ieee in self.device_proxies
+
+        zha_device_proxy = self.device_proxies[ieee]
+        entity_key = (entity_entry.domain, entity_entry.unique_id)
+        if entity_key not in zha_device_proxy.device.platform_entities:
+            return
+        platform_entity = zha_device_proxy.device.platform_entities[entity_key]
+        if entity_entry.disabled:
+            platform_entity.disable()
+        else:
+            platform_entity.enable()
+
     async def async_initialize_devices_and_entities(self) -> None:
         """Initialize devices and entities."""
         for device in self.gateway.devices.values():
@@ -1117,7 +1163,7 @@ def async_add_entities(
     if not entities:
         return
 
-    entities_to_add = []
+    entities_to_add: list[ZHAEntity] = []
     for entity_data in entities:
         try:
             entities_to_add.append(entity_class(entity_data))
@@ -1129,6 +1175,9 @@ def async_add_entities(
                 "Error while adding entity from entity data: %s", entity_data
             )
     _async_add_entities(entities_to_add, update_before_add=False)
+    for entity in entities_to_add:
+        if not entity.enabled:
+            entity.entity_data.entity.disable()
     entities.clear()
 
 
diff --git a/tests/components/zha/test_binary_sensor.py b/tests/components/zha/test_binary_sensor.py
index 419823b3b5202..a9765a1b54779 100644
--- a/tests/components/zha/test_binary_sensor.py
+++ b/tests/components/zha/test_binary_sensor.py
@@ -14,6 +14,7 @@
 )
 from homeassistant.const import STATE_OFF, STATE_ON, Platform
 from homeassistant.core import HomeAssistant
+from homeassistant.helpers import entity_registry as er
 
 from .common import find_entity_id, send_attributes_report
 from .conftest import SIG_EP_INPUT, SIG_EP_OUTPUT, SIG_EP_PROFILE, SIG_EP_TYPE
@@ -37,6 +38,7 @@ def binary_sensor_platform_only():
 
 async def test_binary_sensor(
     hass: HomeAssistant,
+    entity_registry: er.EntityRegistry,
     setup_zha,
     zigpy_device_mock,
 ) -> None:
@@ -77,3 +79,20 @@ async def test_binary_sensor(
         hass, cluster, {general.OnOff.AttributeDefs.on_off.id: OFF}
     )
     assert hass.states.get(entity_id).state == STATE_OFF
+
+    # test enable / disable sync w/ ZHA library
+    entity_entry = entity_registry.async_get(entity_id)
+    entity_key = (Platform.BINARY_SENSOR, entity_entry.unique_id)
+    assert zha_device_proxy.device.platform_entities.get(entity_key).enabled
+
+    entity_registry.async_update_entity(
+        entity_id=entity_id, disabled_by=er.RegistryEntryDisabler.USER
+    )
+    await hass.async_block_till_done()
+
+    assert not zha_device_proxy.device.platform_entities.get(entity_key).enabled
+
+    entity_registry.async_update_entity(entity_id=entity_id, disabled_by=None)
+    await hass.async_block_till_done()
+
+    assert zha_device_proxy.device.platform_entities.get(entity_key).enabled