diff --git a/extensions/smallrye-openapi/deployment/src/main/java/io/quarkus/smallrye/openapi/deployment/SmallRyeOpenApiProcessor.java b/extensions/smallrye-openapi/deployment/src/main/java/io/quarkus/smallrye/openapi/deployment/SmallRyeOpenApiProcessor.java
index e5189cc19c5a77..b5d09571f7ed3b 100644
--- a/extensions/smallrye-openapi/deployment/src/main/java/io/quarkus/smallrye/openapi/deployment/SmallRyeOpenApiProcessor.java
+++ b/extensions/smallrye-openapi/deployment/src/main/java/io/quarkus/smallrye/openapi/deployment/SmallRyeOpenApiProcessor.java
@@ -53,6 +53,7 @@
 
 import io.quarkus.arc.deployment.AdditionalBeanBuildItem;
 import io.quarkus.arc.deployment.BeanArchiveIndexBuildItem;
+import io.quarkus.arc.deployment.BuildExclusionsBuildItem;
 import io.quarkus.arc.deployment.SyntheticBeanBuildItem;
 import io.quarkus.deployment.Capabilities;
 import io.quarkus.deployment.Capability;
@@ -308,13 +309,31 @@ void additionalBean(BuildProducer<AdditionalBeanBuildItem> additionalBeanProduce
 
     @BuildStep
     OpenApiFilteredIndexViewBuildItem smallryeOpenApiIndex(CombinedIndexBuildItem combinedIndexBuildItem,
-            BeanArchiveIndexBuildItem beanArchiveIndexBuildItem) {
-        CompositeIndex compositeIndex = CompositeIndex.create(combinedIndexBuildItem.getIndex(),
+            BeanArchiveIndexBuildItem beanArchiveIndexBuildItem,
+            BuildExclusionsBuildItem buildExclusionsBuildItem) {
+
+        CompositeIndex compositeIndex = CompositeIndex.create(
+                combinedIndexBuildItem.getIndex(),
                 beanArchiveIndexBuildItem.getIndex());
-        return new OpenApiFilteredIndexViewBuildItem(
-                new FilteredIndexView(
-                        compositeIndex,
-                        new OpenApiConfigImpl(ConfigProvider.getConfig())));
+
+        OpenApiConfig config = OpenApiConfig.fromConfig(ConfigProvider.getConfig());
+        Set<DotName> buildTimeClassExclusions = buildExclusionsBuildItem.getExcludedDeclaringClasses()
+                .stream()
+                .map(DotName::createSimple)
+                .collect(Collectors.toSet());
+
+        FilteredIndexView indexView = new FilteredIndexView(compositeIndex, config) {
+            @Override
+            public boolean accepts(DotName className) {
+                if (super.accepts(className)) {
+                    return !buildTimeClassExclusions.contains(className);
+                }
+
+                return false;
+            }
+        };
+
+        return new OpenApiFilteredIndexViewBuildItem(indexView);
     }
 
     @BuildStep
diff --git a/extensions/smallrye-openapi/deployment/src/test/java/io/quarkus/smallrye/openapi/test/jaxrs/OpenApiBuildTimeExcludedClassTestCase.java b/extensions/smallrye-openapi/deployment/src/test/java/io/quarkus/smallrye/openapi/test/jaxrs/OpenApiBuildTimeExcludedClassTestCase.java
new file mode 100644
index 00000000000000..5e18e9b752aa13
--- /dev/null
+++ b/extensions/smallrye-openapi/deployment/src/test/java/io/quarkus/smallrye/openapi/test/jaxrs/OpenApiBuildTimeExcludedClassTestCase.java
@@ -0,0 +1,136 @@
+package io.quarkus.smallrye.openapi.test.jaxrs;
+
+import static org.hamcrest.Matchers.aMapWithSize;
+import static org.hamcrest.Matchers.hasKey;
+import static org.hamcrest.Matchers.not;
+
+import jakarta.ws.rs.GET;
+import jakarta.ws.rs.Path;
+
+import org.jboss.shrinkwrap.api.asset.StringAsset;
+import org.junit.jupiter.api.Test;
+import org.junit.jupiter.api.extension.RegisterExtension;
+
+import io.quarkus.arc.profile.IfBuildProfile;
+import io.quarkus.arc.profile.UnlessBuildProfile;
+import io.quarkus.arc.properties.IfBuildProperty;
+import io.quarkus.arc.properties.UnlessBuildProperty;
+import io.quarkus.test.QuarkusUnitTest;
+import io.restassured.RestAssured;
+
+class OpenApiBuildTimeExcludedClassTestCase {
+
+    static String quarkusProfile;
+
+    @RegisterExtension
+    static QuarkusUnitTest runner = new QuarkusUnitTest()
+            .withApplicationRoot((jar) -> jar
+                    .addClasses(IfBuildProfileTest.class,
+                            IfBuildProfileBar.class,
+                            IfBuildPropertyBarBazIsTrue.class,
+                            IfBuildProperyFooBarIsTrue.class,
+                            UnlessBuildProfileBar.class,
+                            UnlessBuildProfileTest.class,
+                            UnlessBuildPropertyBarBazIsFalse.class,
+                            UnlessBuildProperyFooBarIsFalse.class)
+                    .addAsResource(
+                            new StringAsset("%test.foobar=true\n"
+                                    + "%test.barbaz=false\n"
+                                    + "foobar=false\n"
+                                    + "barbaz=true\n"),
+                            "application.properties"));
+
+    @Test
+    void testAutoSecurityRequirement() {
+        RestAssured.given()
+                .header("Accept", "application/json")
+                .when()
+                .get("/q/openapi")
+                .then()
+                .log().body()
+                .body("paths", aMapWithSize(4))
+
+                .body("paths", hasKey("/test-profile-enabled"))
+                .body("paths", not(hasKey("/test-profile-not-enabled")))
+                .body("paths", hasKey("/bar-profile-not-enabled"))
+                .body("paths", not(hasKey("/bar-profile-enabled")))
+
+                .body("paths", hasKey("/foobar-property-true"))
+                .body("paths", hasKey("/foobar-property-not-false"))
+                .body("paths", not(hasKey("/barbaz-property-true")))
+                .body("paths", not(hasKey("/barbaz-property-not-false")));
+    }
+
+    @Path("/test-profile-enabled")
+    @IfBuildProfile("test")
+    public static class IfBuildProfileTest {
+        @GET
+        public String endpoint() {
+            return "";
+        }
+    }
+
+    @Path("/bar-profile-enabled")
+    @IfBuildProfile("bar")
+    public static class IfBuildProfileBar {
+        @GET
+        public String endpoint() {
+            return "";
+        }
+    }
+
+    @Path("/test-profile-not-enabled")
+    @UnlessBuildProfile("test")
+    public static class UnlessBuildProfileTest {
+        @GET
+        public String endpoint() {
+            return "";
+        }
+    }
+
+    @Path("/bar-profile-not-enabled")
+    @UnlessBuildProfile("bar")
+    public static class UnlessBuildProfileBar {
+        @GET
+        public String endpoint() {
+            return "";
+        }
+    }
+
+    @Path("/foobar-property-true")
+    @IfBuildProperty(name = "foobar", stringValue = "true", enableIfMissing = false)
+    public static class IfBuildProperyFooBarIsTrue {
+        @GET
+        public String endpoint() {
+            return "";
+        }
+    }
+
+    @Path("/barbaz-property-true")
+    @IfBuildProperty(name = "barbaz", stringValue = "true", enableIfMissing = false)
+    public static class IfBuildPropertyBarBazIsTrue {
+        @GET
+        public String endpoint() {
+            return "";
+        }
+    }
+
+    @Path("/foobar-property-not-false")
+    @UnlessBuildProperty(name = "foobar", stringValue = "false", enableIfMissing = false)
+    public static class UnlessBuildProperyFooBarIsFalse {
+        @GET
+        public String endpoint() {
+            return "";
+        }
+    }
+
+    @Path("/barbaz-property-not-false")
+    @UnlessBuildProperty(name = "barbaz", stringValue = "false", enableIfMissing = false)
+    public static class UnlessBuildPropertyBarBazIsFalse {
+        @GET
+        public String endpoint() {
+            return "";
+        }
+    }
+
+}