diff --git a/__snapshots__/cli.js b/__snapshots__/cli.js
index 0d225b291..483c3cd2c 100644
--- a/__snapshots__/cli.js
+++ b/__snapshots__/cli.js
@@ -87,6 +87,8 @@ Options:
   --dry-run             Prepare but do not take action[boolean] [default: false]
   --label               comma-separated list of labels to add to from release PR
                                                [default: "autorelease: pending"]
+  --skip-labeling       skip application of labels to pull requests
+                                                      [boolean] [default: false]
   --fork                should the PR be created from a fork
                                                       [boolean] [default: false]
   --draft-pull-request  mark pull request as a draft  [boolean] [default: false]
@@ -199,6 +201,8 @@ Options:
   --label                           comma-separated list of labels to add to
                                     from release PR
                                                [default: "autorelease: pending"]
+  --skip-labeling                   skip application of labels to pull requests
+                                                      [boolean] [default: false]
   --fork                            should the PR be created from a fork
                                                       [boolean] [default: false]
   --draft-pull-request              mark pull request as a draft
diff --git a/docs/cli.md b/docs/cli.md
index e2d0775e8..839b1262e 100644
--- a/docs/cli.md
+++ b/docs/cli.md
@@ -56,6 +56,7 @@ Extra options:
 | `--draft-pull-request` | `boolean` | If set, create pull requests as drafts |
 | `--label` | `string` | Comma-separated list of labels to apply to the release pull requests. Defaults to `autorelease: pending` |
 | `--release-label` | `string` | Comma-separated list of labels to apply to the pull request after the release has been tagged. Defaults to `autorelease: tagged` |
+| `--skip-labeling` | `boolean` | If set, labels will not be applied to pull requests |
 | `--changelog-path` | `string` | Override the path to the managed CHANGELOG. Defaults to `CHANGELOG.md` |
 | `--changelog-type` | [`ChangelogType`](/docs/customizing.md#changelog-types) | Strategy for building the changelog contents. Defaults to `default` |
 | `--changelog-sections` | `string` | Comma-separated list of commit scopes to show in changelog headings |
diff --git a/src/bin/release-please.ts b/src/bin/release-please.ts
index 99367db8b..47684cfd3 100644
--- a/src/bin/release-please.ts
+++ b/src/bin/release-please.ts
@@ -92,6 +92,7 @@ interface ReleaseArgs {
 interface PullRequestArgs {
   draftPullRequest?: boolean;
   label?: string;
+  skipLabeling?: boolean;
   signoff?: string;
 }
 
@@ -230,6 +231,11 @@ function pullRequestOptions(yargs: yargs.Argv): yargs.Argv {
       default: 'autorelease: pending',
       describe: 'comma-separated list of labels to add to from release PR',
     })
+    .option('skip-labeling', {
+      describe: 'skip application of labels to pull requests',
+      type: 'boolean',
+      default: false,
+    })
     .option('fork', {
       describe: 'should the PR be created from a fork',
       type: 'boolean',
@@ -757,6 +763,9 @@ function extractManifestOptions(
     if (labels.length === 1 && labels[0] === '') labels = [];
     manifestOptions.labels = labels;
   }
+  if ('skipLabeling' in argv && argv.skipLabeling !== undefined) {
+    manifestOptions.skipLabeling = argv.skipLabeling;
+  }
   if ('releaseLabel' in argv && argv.releaseLabel) {
     manifestOptions.releaseLabels = argv.releaseLabel.split(',');
   }
diff --git a/src/github.ts b/src/github.ts
index 00e25b9f7..fd83e4c01 100644
--- a/src/github.ts
+++ b/src/github.ts
@@ -891,12 +891,16 @@ export class GitHub {
     options?: {
       signoffUser?: string;
       fork?: boolean;
+      skipLabeling?: boolean;
     }
   ): Promise<PullRequest> {
     let message = releasePullRequest.title.toString();
     if (options?.signoffUser) {
       message = signoffCommitMessage(message, options.signoffUser);
     }
+    const pullRequestLabels: string[] = options?.skipLabeling
+      ? []
+      : releasePullRequest.labels;
     return await this.createPullRequest(
       {
         headBranchName: releasePullRequest.headRefName,
@@ -904,7 +908,7 @@ export class GitHub {
         number: -1,
         title: releasePullRequest.title.toString(),
         body: releasePullRequest.body.toString().slice(0, MAX_ISSUE_BODY_SIZE),
-        labels: releasePullRequest.labels,
+        labels: pullRequestLabels,
         files: [],
       },
       targetBranch,
diff --git a/src/manifest.ts b/src/manifest.ts
index 4863c095f..448c521cb 100644
--- a/src/manifest.ts
+++ b/src/manifest.ts
@@ -134,6 +134,7 @@ export interface ManifestOptions {
   signoff?: string;
   manifestPath?: string;
   labels?: string[];
+  skipLabeling?: boolean;
   releaseLabels?: string[];
   snapshotLabels?: string[];
   draft?: boolean;
@@ -214,6 +215,7 @@ export class Manifest {
   readonly fork: boolean;
   private signoffUser?: string;
   private labels: string[];
+  private skipLabeling?: boolean;
   private releaseLabels: string[];
   private snapshotLabels: string[];
   private plugins: PluginType[];
@@ -277,6 +279,7 @@ export class Manifest {
     this.releaseLabels =
       manifestOptions?.releaseLabels || DEFAULT_RELEASE_LABELS;
     this.labels = manifestOptions?.labels || DEFAULT_LABELS;
+    this.skipLabeling = manifestOptions?.skipLabeling || false;
     this.snapshotLabels =
       manifestOptions?.snapshotLabels || DEFAULT_SNAPSHOT_LABELS;
     this.bootstrapSha = manifestOptions?.bootstrapSha;
@@ -826,6 +829,7 @@ export class Manifest {
       {
         fork: this.fork,
         signoffUser: this.signoffUser,
+        skipLabeling: this.skipLabeling,
       }
     );
     return newPullRequest;
diff --git a/test/cli.ts b/test/cli.ts
index 0f7d15882..ffe8df873 100644
--- a/test/cli.ts
+++ b/test/cli.ts
@@ -264,6 +264,27 @@ describe('CLI', () => {
       sinon.assert.calledOnce(createPullRequestsStub);
     });
 
+    it('handles --skip-labeling', async () => {
+      await parser.parseAsync(
+        'manifest-pr --repo-url=googleapis/release-please-cli --skip-labeling'
+      );
+
+      sinon.assert.calledOnceWithExactly(gitHubCreateStub, {
+        owner: 'googleapis',
+        repo: 'release-please-cli',
+        token: undefined,
+      });
+      sinon.assert.calledOnceWithExactly(
+        fromManifestStub,
+        fakeGitHub,
+        'main',
+        DEFAULT_RELEASE_PLEASE_CONFIG,
+        DEFAULT_RELEASE_PLEASE_MANIFEST,
+        sinon.match({skipLabeling: true})
+      );
+      sinon.assert.calledOnce(createPullRequestsStub);
+    });
+
     // it('handles --draft', async () => {
     //   await parser.parseAsync(
     //     'manifest-pr --repo-url=googleapis/release-please-cli --draft'