diff --git a/noxfile.py b/noxfile.py
index 6ee8c4519..0ad24c69c 100644
--- a/noxfile.py
+++ b/noxfile.py
@@ -123,6 +123,9 @@ def system(session):
     # Sanity check: Only run tests if the environment variable is set.
     if not os.environ.get("GOOGLE_APPLICATION_CREDENTIALS", ""):
         session.skip("Credentials must be set via environment variable")
+    # Install pyopenssl for mTLS testing.
+    if os.environ.get("GOOGLE_API_USE_CLIENT_CERTIFICATE", "false") == "true":
+        session.install("pyopenssl")
 
     system_test_exists = os.path.exists(system_test_path)
     system_test_folder_exists = os.path.exists(system_test_folder_path)