diff --git a/CHANGELOG.md b/CHANGELOG.md
index 5af0b29b0..c37a76bbb 100644
--- a/CHANGELOG.md
+++ b/CHANGELOG.md
@@ -10,6 +10,7 @@
     config.rails.active_support_logger_subscription_items.delete("sql.active_record")
     config.rails.active_support_logger_subscription_items["foo"] = :bar
   ```
+- Enable opting out of patches [#2151](https://github.com/getsentry/sentry-ruby/pull/2151)
 
 ### Bug Fixes
 
diff --git a/sentry-ruby/lib/sentry-ruby.rb b/sentry-ruby/lib/sentry-ruby.rb
index 59edf50d7..c3577d0f0 100644
--- a/sentry-ruby/lib/sentry-ruby.rb
+++ b/sentry-ruby/lib/sentry-ruby.rb
@@ -75,15 +75,15 @@ def exception_locals_tp
     ##### Patch Registration #####
 
     # @!visibility private
-    def register_patch(patch = nil, target = nil, &block)
+    def register_patch(key, patch = nil, target = nil, &block)
       if patch && block
         raise ArgumentError.new("Please provide either a patch and its target OR a block, but not both")
       end
 
       if block
-        registered_patches << block
+        registered_patches[key] = block
       else
-        registered_patches << proc do
+        registered_patches[key] = proc do
           target.send(:prepend, patch) unless target.ancestors.include?(patch)
         end
       end
@@ -91,14 +91,14 @@ def register_patch(patch = nil, target = nil, &block)
 
     # @!visibility private
     def apply_patches(config)
-      registered_patches.each do |patch|
-        patch.call(config)
+      registered_patches.each do |key, patch|
+        patch.call(config) if config.enabled_patches.include?(key)
       end
     end
 
     # @!visibility private
     def registered_patches
-      @registered_patches ||= []
+      @registered_patches ||= {}
     end
 
     ##### Integrations #####
diff --git a/sentry-ruby/lib/sentry/configuration.rb b/sentry-ruby/lib/sentry/configuration.rb
index 11c2ce3bd..1f89f31a3 100644
--- a/sentry-ruby/lib/sentry/configuration.rb
+++ b/sentry-ruby/lib/sentry/configuration.rb
@@ -258,6 +258,11 @@ def capture_exception_frame_locals=(value)
     # @return [Float, nil]
     attr_reader :profiles_sample_rate
 
+    # Array of patches to apply.
+    # Default is {DEFAULT_PATCHES}
+    # @return [Array<Symbol>]
+    attr_accessor :enabled_patches
+
     # these are not config options
     # @!visibility private
     attr_reader :errors, :gem_specs
@@ -297,6 +302,8 @@ def capture_exception_frame_locals=(value)
 
     PROPAGATION_TARGETS_MATCH_ALL = /.*/.freeze
 
+    DEFAULT_PATCHES = %i(redis puma http).freeze
+
     class << self
       # Post initialization callbacks are called at the end of initialization process
       # allowing extending the configuration of sentry-ruby by multiple extensions
@@ -340,6 +347,7 @@ def initialize
       self.server_name = server_name_from_env
       self.instrumenter = :sentry
       self.trace_propagation_targets = [PROPAGATION_TARGETS_MATCH_ALL]
+      self.enabled_patches = DEFAULT_PATCHES.dup
 
       self.before_send = nil
       self.before_send_transaction = nil
diff --git a/sentry-ruby/lib/sentry/net/http.rb b/sentry-ruby/lib/sentry/net/http.rb
index 634753937..71c61ca3e 100644
--- a/sentry-ruby/lib/sentry/net/http.rb
+++ b/sentry-ruby/lib/sentry/net/http.rb
@@ -99,4 +99,4 @@ def propagate_trace?(url, configuration)
   end
 end
 
-Sentry.register_patch(Sentry::Net::HTTP, Net::HTTP)
+Sentry.register_patch(:http, Sentry::Net::HTTP, Net::HTTP)
diff --git a/sentry-ruby/lib/sentry/puma.rb b/sentry-ruby/lib/sentry/puma.rb
index 69a937fb3..56e874771 100644
--- a/sentry-ruby/lib/sentry/puma.rb
+++ b/sentry-ruby/lib/sentry/puma.rb
@@ -29,4 +29,4 @@ def lowlevel_error(e, env, status=500)
   end
 end
 
-Sentry.register_patch(Sentry::Puma::Server, Puma::Server)
+Sentry.register_patch(:puma, Sentry::Puma::Server, Puma::Server)
diff --git a/sentry-ruby/lib/sentry/redis.rb b/sentry-ruby/lib/sentry/redis.rb
index befe868aa..3c3832321 100644
--- a/sentry-ruby/lib/sentry/redis.rb
+++ b/sentry-ruby/lib/sentry/redis.rb
@@ -99,8 +99,10 @@ def call_pipelined(commands, redis_config)
 
 if defined?(::Redis::Client)
   if Gem::Version.new(::Redis::VERSION) < Gem::Version.new("5.0")
-    Sentry.register_patch(Sentry::Redis::OldClientPatch, ::Redis::Client)
+    Sentry.register_patch(:redis, Sentry::Redis::OldClientPatch, ::Redis::Client)
   elsif defined?(RedisClient)
-    RedisClient.register(Sentry::Redis::GlobalRedisInstrumentation)
+    Sentry.register_patch(:redis) do
+      RedisClient.register(Sentry::Redis::GlobalRedisInstrumentation)
+    end
   end
 end
diff --git a/sentry-ruby/spec/sentry/configuration_spec.rb b/sentry-ruby/spec/sentry/configuration_spec.rb
index 6cd571600..5e4beb7ee 100644
--- a/sentry-ruby/spec/sentry/configuration_spec.rb
+++ b/sentry-ruby/spec/sentry/configuration_spec.rb
@@ -542,4 +542,15 @@ class SentryConfigurationSample < Sentry::Configuration
       expect(subject.instrumenter).to eq(:sentry)
     end
   end
+
+  describe "#enabled_patches" do
+    it "sets default patches" do
+      expect(subject.enabled_patches).to eq(%i(redis puma http))
+    end
+
+    it "can override" do
+      subject.enabled_patches.delete(:puma)
+      expect(subject.enabled_patches).to eq(%i(redis http))
+    end
+  end
 end
diff --git a/sentry-ruby/spec/sentry_spec.rb b/sentry-ruby/spec/sentry_spec.rb
index 80c74180f..da784a6bf 100644
--- a/sentry-ruby/spec/sentry_spec.rb
+++ b/sentry-ruby/spec/sentry_spec.rb
@@ -1032,4 +1032,56 @@
       end.to change { new_transport.events.count }.by(1)
     end
   end
+
+  describe "patching" do
+    let(:target_class) { Class.new }
+
+    let(:module_patch) do
+      Module.new do
+        def foo; end
+      end
+    end
+
+    context "with target and patch to prepend" do
+      before do
+        described_class.register_patch(:module_patch, module_patch, target_class)
+      end
+
+      it "does not prepend patch if not in enabled_patches" do
+        perform_basic_setup
+        expect(target_class.ancestors).not_to include(module_patch)
+        expect(target_class.instance_methods).not_to include(:foo)
+      end
+
+      it "prepends patch if in enabled_patches" do
+        expect(target_class).to receive(:prepend).with(module_patch).and_call_original
+        perform_basic_setup  { |c| c.enabled_patches = %i(module_patch) }
+
+        expect(target_class.ancestors.first).to eq(module_patch)
+        expect(target_class.instance_methods).to include(:foo)
+      end
+    end
+
+    context "with block" do
+      before do
+        described_class.register_patch(:block_patch) do
+          target_class.send(:prepend, module_patch)
+        end
+      end
+
+      it "does not call block if not in enabled_patches" do
+        perform_basic_setup
+        expect(target_class.ancestors).not_to include(module_patch)
+        expect(target_class.instance_methods).not_to include(:foo)
+      end
+
+      it "calls block if in enabled_patches" do
+        expect(target_class).to receive(:prepend).with(module_patch).and_call_original
+        perform_basic_setup  { |c| c.enabled_patches = %i(block_patch) }
+
+        expect(target_class.ancestors.first).to eq(module_patch)
+        expect(target_class.instance_methods).to include(:foo)
+      end
+    end
+  end
 end