diff --git a/moto/dynamodb2/responses.py b/moto/dynamodb2/responses.py
index fe1a463d63c6..5958a38c93cc 100644
--- a/moto/dynamodb2/responses.py
+++ b/moto/dynamodb2/responses.py
@@ -349,6 +349,12 @@ def batch_write_item(self):
 
     def get_item(self):
         name = self.body["TableName"]
+        table = self.dynamodb_backend.get_table(name)
+        if table is None:
+            return self.error(
+                "com.amazonaws.dynamodb.v20120810#ResourceNotFoundException",
+                "Requested resource not found",
+            )
         key = self.body["Key"]
         projection_expression = self.body.get("ProjectionExpression")
         expression_attribute_names = self.body.get("ExpressionAttributeNames", {})
diff --git a/tests/test_dynamodb2/test_dynamodb.py b/tests/test_dynamodb2/test_dynamodb.py
index 2ad45ddc7060..446d0238096d 100644
--- a/tests/test_dynamodb2/test_dynamodb.py
+++ b/tests/test_dynamodb2/test_dynamodb.py
@@ -5698,3 +5698,12 @@ def test_update_item_add_to_list_using_legacy_attribute_updates():
 
     resp = table.get_item(Key={"id": "list_add"})
     resp["Item"]["attr"].should.equal(["a", "b", "c", "d", "e"])
+
+
+@mock_dynamodb2
+def test_get_item_for_non_existent_table_raises_error():
+    client = boto3.client("dynamodb", "us-east-1")
+    with pytest.raises(ClientError) as ex:
+        client.get_item(TableName="non-existent", Key={"site-id": {"S": "foo"}})
+    ex.value.response["Error"]["Code"].should.equal("ResourceNotFoundException")
+    ex.value.response["Error"]["Message"].should.equal("Requested resource not found")