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Update gene product of collagen type XI trimer #29508

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DaiqingChen opened this issue Jan 2, 2025 · 1 comment
Open

Update gene product of collagen type XI trimer #29508

DaiqingChen opened this issue Jan 2, 2025 · 1 comment
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@DaiqingChen
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DaiqingChen commented Jan 2, 2025

  • The annotations of collagen type XI trimer (GO:0005592) within homo sapients are as follow:
    Contain COL2A1, COL5A2, COL11A1, COL11A2, COL28A1
    Image

  • Gene product name and ID to be annotated to this term
    Should be COL11A1, COL11A2,COL2A1(COL11A3), COL5A1, COL5A2.
    Need to add: COL5A1
    Need to remove: COL28A1 in all species, Col4a1_0 in smithornis capensis, col9a1b in Betta splendens, Col27a1 in Castor canadensis. These annotations are inferred from phylogenetic tree, screenshot of the last three are as follow:

    Image Image Image
  • Reference, in format PMID:#######
    In complex protal (https://www.ebi.ac.uk/complexportal/home), there are three collagen type XI trimer:

Image

Variant 1 has COL2A1, COL11A1, COL11A2;
Variant 2 has 2*COL5A2, COL11A2;
Variant 3 has COL5A1, COL5A2, COL11A1.

@DaiqingChen DaiqingChen assigned pgaudet and unassigned pgaudet Jan 3, 2025
@Matrisome
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See also: PMID: 20705069

@Matrisome Matrisome added the ready label Jan 4, 2025
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