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feat: Add average & delta PAU values to final 'processed' DEXSeq results table #4

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SamBryce-Smith opened this issue May 16, 2023 · 0 comments

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@SamBryce-Smith
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depends on #3

Update workflow/scripts/process_dexseq_tbl.R to add average TPM, PAU & delta columns to DEXSeq results table.

Details TBC.

random thought/concern - should we recalculate PAU based on expressions of filtered/assessed PAS? DEXSeq script will perform some pre-filtering (minimum expression & relative expression) on individual PAS), so PAUs calculated from QAPA output may be based on a different set of PAS for the gene than evaluated by DEXSeq. Could do it just group-wise (e.g. use the mean/median TPMs of assessed PAS to re-calculate PAUs), or alternatively use the normalised count matrix to calculate?

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