diff --git a/packages/legacy-events/__tests__/ResponderEventPlugin-test.internal.js b/packages/legacy-events/__tests__/ResponderEventPlugin-test.internal.js
index 8234f6144e6d0..6f1acf879a1cb 100644
--- a/packages/legacy-events/__tests__/ResponderEventPlugin-test.internal.js
+++ b/packages/legacy-events/__tests__/ResponderEventPlugin-test.internal.js
@@ -404,11 +404,10 @@ describe('ResponderEventPlugin', () => {
   beforeEach(() => {
     jest.resetModules();
 
-    const ReactDOMUnstableNativeDependencies = require('react-dom/unstable-native-dependencies');
     EventBatching = require('legacy-events/EventBatching');
     EventPluginUtils = require('legacy-events/EventPluginUtils');
-    ResponderEventPlugin =
-      ReactDOMUnstableNativeDependencies.ResponderEventPlugin;
+    ResponderEventPlugin = require('legacy-events/ResponderEventPlugin')
+      .default;
 
     deleteAllListeners(GRANDPARENT_INST);
     deleteAllListeners(PARENT_INST);
diff --git a/packages/react-dom/npm/unstable-native-dependencies.js b/packages/react-dom/npm/unstable-native-dependencies.js
deleted file mode 100644
index 6a498a3686e6a..0000000000000
--- a/packages/react-dom/npm/unstable-native-dependencies.js
+++ /dev/null
@@ -1,7 +0,0 @@
-'use strict';
-
-if (process.env.NODE_ENV === 'production') {
-  module.exports = require('./cjs/react-dom-unstable-native-dependencies.production.min.js');
-} else {
-  module.exports = require('./cjs/react-dom-unstable-native-dependencies.development.js');
-}
diff --git a/packages/react-dom/package.json b/packages/react-dom/package.json
index 1fb6e427947e5..a251967e3c63d 100644
--- a/packages/react-dom/package.json
+++ b/packages/react-dom/package.json
@@ -38,7 +38,6 @@
     "unstable-fizz.js",
     "unstable-fizz.browser.js",
     "unstable-fizz.node.js",
-    "unstable-native-dependencies.js",
     "cjs/",
     "umd/"
   ],
diff --git a/packages/react-dom/src/client/ReactDOM.js b/packages/react-dom/src/client/ReactDOM.js
index 5de914e345134..6f54abb6e81dc 100644
--- a/packages/react-dom/src/client/ReactDOM.js
+++ b/packages/react-dom/src/client/ReactDOM.js
@@ -172,8 +172,8 @@ function unstable_createPortal(
 }
 
 const Internals = {
-  // Keep in sync with ReactDOMUnstableNativeDependencies.js
-  // ReactTestUtils.js, and ReactTestUtilsAct.js. This is an array for better minification.
+  // Keep in sync with ReactTestUtils.js, and ReactTestUtilsAct.js.
+  // This is an array for better minification.
   Events: [
     getInstanceFromNode,
     getNodeFromInstance,
diff --git a/packages/react-dom/src/test-utils/ReactTestUtils.js b/packages/react-dom/src/test-utils/ReactTestUtils.js
index 2348a047ba9fd..9cce946759030 100644
--- a/packages/react-dom/src/test-utils/ReactTestUtils.js
+++ b/packages/react-dom/src/test-utils/ReactTestUtils.js
@@ -25,8 +25,7 @@ import accumulateInto from 'legacy-events/accumulateInto';
 import {enableModernEventSystem} from 'shared/ReactFeatureFlags';
 
 const {findDOMNode} = ReactDOM;
-// Keep in sync with ReactDOMUnstableNativeDependencies.js
-// ReactDOM.js, and ReactTestUtilsAct.js:
+// Keep in sync with ReactDOM.js, and ReactTestUtilsAct.js:
 const [
   getInstanceFromNode,
   /* eslint-disable no-unused-vars */
diff --git a/packages/react-dom/src/test-utils/ReactTestUtilsAct.js b/packages/react-dom/src/test-utils/ReactTestUtilsAct.js
index c1bab1c869c3e..3061bf2b5e7e8 100644
--- a/packages/react-dom/src/test-utils/ReactTestUtilsAct.js
+++ b/packages/react-dom/src/test-utils/ReactTestUtilsAct.js
@@ -14,8 +14,7 @@ import ReactSharedInternals from 'shared/ReactSharedInternals';
 import enqueueTask from 'shared/enqueueTask';
 import * as Scheduler from 'scheduler';
 
-// Keep in sync with ReactDOMUnstableNativeDependencies.js
-// ReactDOM.js, and ReactTestUtils.js:
+// Keep in sync with ReactDOM.js, and ReactTestUtils.js:
 const [
   /* eslint-disable no-unused-vars */
   getInstanceFromNode,
diff --git a/packages/react-dom/src/unstable-native-dependencies/ReactDOMUnstableNativeDependencies.js b/packages/react-dom/src/unstable-native-dependencies/ReactDOMUnstableNativeDependencies.js
deleted file mode 100644
index 622819940bd28..0000000000000
--- a/packages/react-dom/src/unstable-native-dependencies/ReactDOMUnstableNativeDependencies.js
+++ /dev/null
@@ -1,32 +0,0 @@
-/**
- * Copyright (c) Facebook, Inc. and its affiliates.
- *
- * This source code is licensed under the MIT license found in the
- * LICENSE file in the root directory of this source tree.
- */
-
-import * as ReactDOM from 'react-dom';
-import {setComponentTree} from 'legacy-events/EventPluginUtils';
-import ResponderEventPlugin from 'legacy-events/ResponderEventPlugin';
-import ResponderTouchHistoryStore from 'legacy-events/ResponderTouchHistoryStore';
-
-// Inject react-dom's ComponentTree into this module.
-// Keep in sync with ReactDOM.js, ReactTestUtils.js, and ReactTestUtilsAct.js:
-const [
-  getInstanceFromNode,
-  getNodeFromInstance,
-  getFiberCurrentPropsFromNode,
-  injectEventPluginsByName,
-] = ReactDOM.__SECRET_INTERNALS_DO_NOT_USE_OR_YOU_WILL_BE_FIRED.Events;
-
-setComponentTree(
-  getFiberCurrentPropsFromNode,
-  getInstanceFromNode,
-  getNodeFromInstance,
-);
-
-export {
-  ResponderEventPlugin,
-  ResponderTouchHistoryStore,
-  injectEventPluginsByName,
-};
diff --git a/packages/react-dom/unstable-native-dependencies.js b/packages/react-dom/unstable-native-dependencies.js
deleted file mode 100644
index ec502fb890690..0000000000000
--- a/packages/react-dom/unstable-native-dependencies.js
+++ /dev/null
@@ -1,10 +0,0 @@
-/**
- * Copyright (c) Facebook, Inc. and its affiliates.
- *
- * This source code is licensed under the MIT license found in the
- * LICENSE file in the root directory of this source tree.
- *
- * @flow
- */
-
-export * from './src/unstable-native-dependencies/ReactDOMUnstableNativeDependencies';
diff --git a/scripts/rollup/bundles.js b/scripts/rollup/bundles.js
index ef87db971cf23..8c87b1fd81af5 100644
--- a/scripts/rollup/bundles.js
+++ b/scripts/rollup/bundles.js
@@ -155,15 +155,6 @@ const bundles = [
     externals: ['react'],
   },
 
-  /* React DOM internals required for react-native-web (e.g., to shim native events from react-dom) */
-  {
-    bundleTypes: [UMD_DEV, UMD_PROD, NODE_DEV, NODE_PROD],
-    moduleType: RENDERER_UTILS,
-    entry: 'react-dom/unstable-native-dependencies',
-    global: 'ReactDOMUnstableNativeDependencies',
-    externals: ['react', 'react-dom'],
-  },
-
   /******* React DOM Server *******/
   {
     bundleTypes: [