diff --git a/newsfragments/1794.bugfix.rst b/newsfragments/1794.bugfix.rst
new file mode 100644
index 0000000000..f289ce8fed
--- /dev/null
+++ b/newsfragments/1794.bugfix.rst
@@ -0,0 +1 @@
+Handle revert reason parsing for Ganache
diff --git a/tests/core/utilities/test_method_formatters.py b/tests/core/utilities/test_method_formatters.py
index 1dd367f165..ae75f09ae7 100644
--- a/tests/core/utilities/test_method_formatters.py
+++ b/tests/core/utilities/test_method_formatters.py
@@ -14,6 +14,7 @@
     RPCResponse,
 )
 
+# OpenEthereum/default case:
 REVERT_WITH_MSG = RPCResponse({
     'jsonrpc': '2.0',
     'error': {
@@ -49,16 +50,48 @@
     "id": 1,
 })
 
+GETH_RESPONSE = RPCResponse({
+    'jsonrpc': '2.0',
+    'id': 2,
+    'error': {
+        'code': 3,
+        'message': 'execution reverted: Function has been reverted.',
+        'data': (
+            '0x08c379a0000000000000000000000000000000000000000000000'
+            '0000000000000000020000000000000000000000000000000000000'
+            '000000000000000000000000001b46756e6374696f6e20686173206'
+            '265656e2072657665727465642e0000000000'
+        ),
+    },
+})
+
+GANACHE_RESPONSE = RPCResponse({
+    'id': 24,
+    'jsonrpc': '2.0',
+    'error': {
+        'message': 'VM Exception while processing transaction: revert Custom revert message',
+        'code': -32000,
+        'data': {
+            'stack': 'o: VM Exception while processing transaction: revert Custom revert message\n',
+            'name': 'o'
+        }
+    }
+})
+
 
 @pytest.mark.parametrize(
     "response,expected",
     (
         (REVERT_WITH_MSG, 'execution reverted: not allowed to monitor'),
         (REVERT_WITHOUT_MSG, 'execution reverted'),
+        (GETH_RESPONSE, 'execution reverted: Function has been reverted.'),
+        (GANACHE_RESPONSE, 'execution reverted: VM Exception while processing transaction: revert Custom revert message'),  # noqa: 501
     ),
     ids=[
         'test-get-revert-reason-with-msg',
         'test-get-revert-reason-without-msg',
+        'test-get-geth-revert-reason',
+        'test_get-ganache-revert-reason',
     ])
 def test_get_revert_reason(response, expected) -> None:
     with pytest.raises(SolidityError, match=expected):
diff --git a/web3/_utils/method_formatters.py b/web3/_utils/method_formatters.py
index 6c83d6b110..6c45a7f206 100644
--- a/web3/_utils/method_formatters.py
+++ b/web3/_utils/method_formatters.py
@@ -485,8 +485,13 @@ def raise_solidity_error_on_revert(response: RPCResponse) -> RPCResponse:
     if not isinstance(response['error'], dict):
         raise ValueError('Error expected to be a dict')
 
-    # Parity/OpenEthereum case:
     data = response['error'].get('data', '')
+
+    # Ganache case:
+    if isinstance(data, dict) and response['error'].get('message'):
+        raise SolidityError(f'execution reverted: {response["error"]["message"]}')
+
+    # Parity/OpenEthereum case:
     if data.startswith('Reverted '):
         # "Reverted", function selector and offset are always the same for revert errors
         prefix = 'Reverted 0x08c379a00000000000000000000000000000000000000000000000000000000000000020'  # noqa: 501