diff --git a/cores/esp32/HWCDC.cpp b/cores/esp32/HWCDC.cpp
index a608fff83c0..cc84727d12f 100644
--- a/cores/esp32/HWCDC.cpp
+++ b/cores/esp32/HWCDC.cpp
@@ -15,6 +15,7 @@
 #if CONFIG_IDF_TARGET_ESP32C3 || CONFIG_IDF_TARGET_ESP32S3
 
 #include "esp32-hal.h"
+#include "esp32-hal-periman.h"
 #include "HWCDC.h"
 #include "freertos/FreeRTOS.h"
 #include "freertos/semphr.h"
@@ -22,6 +23,7 @@
 #include "freertos/ringbuf.h"
 #include "esp_intr_alloc.h"
 #include "soc/periph_defs.h"
+#include "soc/io_mux_reg.h"
 #pragma GCC diagnostic ignored "-Wvolatile"
 #include "hal/usb_serial_jtag_ll.h"
 #pragma GCC diagnostic warning "-Wvolatile"
@@ -171,6 +173,28 @@ void HWCDC::onEvent(arduino_hw_cdc_event_t event, esp_event_handler_t callback){
     arduino_hw_cdc_event_handler_register_with(ARDUINO_HW_CDC_EVENTS, event, callback, this);
 }
 
+bool HWCDC::deinit(void * busptr) 
+{
+    // avoid any recursion issue with Peripheral Manager perimanSetPinBus() call
+    static bool running = false;
+    if (running) return true;
+    running = true; 
+    // Setting USB D+ D- pins
+    bool retCode = true;
+    retCode &= perimanSetPinBus(USB_DM_GPIO_NUM, ESP32_BUS_TYPE_INIT, NULL);
+    retCode &= perimanSetPinBus(USB_DP_GPIO_NUM, ESP32_BUS_TYPE_INIT, NULL);
+    if (retCode) {
+        // Force the host to re-enumerate (BUS_RESET)
+        pinMode(USB_DM_GPIO_NUM, OUTPUT_OPEN_DRAIN);
+        pinMode(USB_DP_GPIO_NUM, OUTPUT_OPEN_DRAIN);
+        digitalWrite(USB_DM_GPIO_NUM, LOW);
+        digitalWrite(USB_DP_GPIO_NUM, LOW);
+    }
+    // release the flag
+    running = false;
+    return retCode;
+}
+
 void HWCDC::begin(unsigned long baud)
 {
     if(tx_lock == NULL) {
@@ -187,6 +211,14 @@ void HWCDC::begin(unsigned long baud)
         end();
         return;
     }
+    if (perimanSetBusDeinit(ESP32_BUS_TYPE_USB, HWCDC::deinit)) {
+        // Setting USB D+ D- pins
+        perimanSetPinBus(USB_DM_GPIO_NUM, ESP32_BUS_TYPE_USB, (void *) this);
+        perimanSetPinBus(USB_DP_GPIO_NUM, ESP32_BUS_TYPE_USB, (void *) this);
+    } else {
+        log_e("Serial JTAG Pins can't be set into Peripheral Manager.");
+    }
+
     usb_serial_jtag_ll_txfifo_flush();
 }
 
@@ -206,6 +238,7 @@ void HWCDC::end()
         esp_event_loop_delete(arduino_hw_cdc_event_loop_handle);
         arduino_hw_cdc_event_loop_handle = NULL;
     }
+    HWCDC::deinit(this);
 }
 
 void HWCDC::setTxTimeoutMs(uint32_t timeout){
diff --git a/cores/esp32/HWCDC.h b/cores/esp32/HWCDC.h
index 5878ad0377f..fa0536f6268 100644
--- a/cores/esp32/HWCDC.h
+++ b/cores/esp32/HWCDC.h
@@ -42,6 +42,9 @@ typedef union {
 
 class HWCDC: public Stream
 {
+private:
+    static bool deinit(void * busptr);
+    
 public:
     HWCDC();
     ~HWCDC();
diff --git a/cores/esp32/esp32-hal-tinyusb.c b/cores/esp32/esp32-hal-tinyusb.c
index c107aef2140..4df6b1d26fa 100644
--- a/cores/esp32/esp32-hal-tinyusb.c
+++ b/cores/esp32/esp32-hal-tinyusb.c
@@ -32,6 +32,7 @@
 #include "esp_rom_gpio.h"
 
 #include "esp32-hal.h"
+#include "esp32-hal-periman.h"
 
 #include "esp32-hal-tinyusb.h"
 #if CONFIG_IDF_TARGET_ESP32S2
@@ -56,6 +57,11 @@ typedef struct {
     bool external_phy;
 } tinyusb_config_t;
 
+static bool usb_otg_deinit(void * busptr) {
+    // Once USB OTG is initialized, its GPIOs are assigned and it shall never be deinited
+    return false;
+}
+
 static void configure_pins(usb_hal_context_t *usb)
 {
     for (const usb_iopin_dsc_t *iopin = usb_periph_iopins; iopin->pin != -1; ++iopin) {
@@ -75,6 +81,13 @@ static void configure_pins(usb_hal_context_t *usb)
     if (!usb->use_external_phy) {
         gpio_set_drive_capability(USBPHY_DM_NUM, GPIO_DRIVE_CAP_3);
         gpio_set_drive_capability(USBPHY_DP_NUM, GPIO_DRIVE_CAP_3);
+        if (perimanSetBusDeinit(ESP32_BUS_TYPE_USB, usb_otg_deinit)) {
+            // Bus Pointer is not used anyway - once the USB GPIOs are assigned, they can't be detached
+            perimanSetPinBus(USBPHY_DM_NUM, ESP32_BUS_TYPE_USB, (void *) usb);
+            perimanSetPinBus(USBPHY_DP_NUM, ESP32_BUS_TYPE_USB, (void *) usb);
+        } else {
+            log_e("USB OTG Pins can't be set into Peripheral Manager.");
+        }
     }
 }