diff --git a/test/server/server_corpus/clusterfuzz-testcase-server_fuzz_test-5763613693837312 b/test/server/server_corpus/clusterfuzz-testcase-server_fuzz_test-5763613693837312
new file mode 100644
index 000000000000..9c3fe726b36d
--- /dev/null
+++ b/test/server/server_corpus/clusterfuzz-testcase-server_fuzz_test-5763613693837312
@@ -0,0 +1,7 @@
+stats_sinks {
+  typed_config {
+    type_url: "type.googleapis.com/envoy.api.v2.route.Route"
+    value: "\022*J :222222\377\377\377\377\377\377\377\377\377\377\377\377\377\377\377\377\377\377\377\377\377\377\377\377\377\377\377\377\t2871770\377\377\377\377\377\377\377\377\377\377\377\377\377\377\377\377\377\0378\377\377\377\377\377\377\377\377 8\377\377\377\377\377\377\377\377\37722222222222222222220\022"
+  }
+}
+header_prefix: "type.googleapis.com/envoy.api.v2.route.Route"
diff --git a/test/server/server_fuzz_test.cc b/test/server/server_fuzz_test.cc
index 53db522ebbb0..2ee39d2f8d88 100644
--- a/test/server/server_fuzz_test.cc
+++ b/test/server/server_fuzz_test.cc
@@ -37,6 +37,9 @@ makeHermeticPathsAndPorts(Fuzz::PerTestEnvironment& test_env,
   // we lose here. If we don't sanitize here, we get flakes due to port bind conflicts, file
   // conflicts, etc.
   output.clear_admin();
+  // The header_prefix is a write-once then read-only singleton that persists across tests. We clear
+  // this field so that fuzz tests don't fail over multiple iterations.
+  output.clear_header_prefix();
   if (output.has_runtime()) {
     output.mutable_runtime()->set_symlink_root(test_env.temporaryPath(""));
   }