diff --git a/changelog.d/17563.misc b/changelog.d/17563.misc
new file mode 100644
index 00000000000..672764ab82f
--- /dev/null
+++ b/changelog.d/17563.misc
@@ -0,0 +1 @@
+Reduce log spam of multipart files.
diff --git a/synapse/http/client.py b/synapse/http/client.py
index 56ad28eabf3..daa5cc899b9 100644
--- a/synapse/http/client.py
+++ b/synapse/http/client.py
@@ -1088,7 +1088,6 @@ def on_part_data(data: bytes, start: int, end: int) -> None:
                     return
                 # otherwise we are in the file part
                 else:
-                    logger.info("Writing multipart file data to stream")
                     try:
                         self.stream.write(data[start:end])
                     except Exception as e: