diff --git a/x-pack/plugins/security_solution/server/endpoint/lib/artifacts/lists.ts b/x-pack/plugins/security_solution/server/endpoint/lib/artifacts/lists.ts
index 581b46deebcfd..dc31e852e7206 100644
--- a/x-pack/plugins/security_solution/server/endpoint/lib/artifacts/lists.ts
+++ b/x-pack/plugins/security_solution/server/endpoint/lib/artifacts/lists.ts
@@ -14,7 +14,7 @@ import type {
 } from '@kbn/securitysolution-io-ts-list-types';
 import { validate } from '@kbn/securitysolution-io-ts-utils';
 import type { OperatingSystem } from '@kbn/securitysolution-utils';
-import { hasSimpleExecutableName } from '@kbn/securitysolution-utils';
+import { EntryFieldType, hasSimpleExecutableName } from '@kbn/securitysolution-utils';
 
 import type {
   ENDPOINT_BLOCKLISTS_LIST_ID,
@@ -22,7 +22,7 @@ import type {
   ENDPOINT_HOST_ISOLATION_EXCEPTIONS_LIST_ID,
   ENDPOINT_TRUSTED_APPS_LIST_ID,
 } from '@kbn/securitysolution-list-constants';
-import { ENDPOINT_LIST_ID } from '@kbn/securitysolution-list-constants';
+import { ENDPOINT_LIST_ID, ENDPOINT_ARTIFACT_LISTS } from '@kbn/securitysolution-list-constants';
 import type { ExceptionListClient } from '@kbn/lists-plugin/server';
 import type {
   InternalArtifactCompleteSchema,
@@ -168,13 +168,36 @@ export function translateToEndpointExceptions(
   const entriesFiltered: TranslatedExceptionListItem[] = [];
   if (schemaVersion === 'v1') {
     exceptions.forEach((entry) => {
-      const translatedItem = translateItem(schemaVersion, entry);
-      const entryHash = createHash('sha256').update(JSON.stringify(translatedItem)).digest('hex');
-      if (!entrySet.has(entryHash)) {
-        entriesFiltered.push(translatedItem);
-        entrySet.add(entryHash);
+      // For Blocklist, we create a single entry for each blocklist entry item
+      // if there is an entry with more than one hash type.
+      if (
+        entry.list_id === ENDPOINT_ARTIFACT_LISTS.blocklists.id &&
+        entry.entries.length > 1 &&
+        !!entry.entries[0].field.match(EntryFieldType.HASH)
+      ) {
+        entry.entries.forEach((blocklistSingleEntry) => {
+          const translatedItem = translateItem(schemaVersion, {
+            ...entry,
+            entries: [blocklistSingleEntry],
+          });
+          const entryHash = createHash('sha256')
+            .update(JSON.stringify(translatedItem))
+            .digest('hex');
+          if (!entrySet.has(entryHash)) {
+            entriesFiltered.push(translatedItem);
+            entrySet.add(entryHash);
+          }
+        });
+      } else {
+        const translatedItem = translateItem(schemaVersion, entry);
+        const entryHash = createHash('sha256').update(JSON.stringify(translatedItem)).digest('hex');
+        if (!entrySet.has(entryHash)) {
+          entriesFiltered.push(translatedItem);
+          entrySet.add(entryHash);
+        }
       }
     });
+
     return entriesFiltered;
   } else {
     throw new Error('unsupported schemaVersion');
diff --git a/x-pack/test/security_solution_endpoint/apps/integrations/mocks.ts b/x-pack/test/security_solution_endpoint/apps/integrations/mocks.ts
index 8da54b7ed1443..25c39602662c2 100644
--- a/x-pack/test/security_solution_endpoint/apps/integrations/mocks.ts
+++ b/x-pack/test/security_solution_endpoint/apps/integrations/mocks.ts
@@ -368,7 +368,8 @@ export const getArtifactsListTestsData = () => [
         {
           type: 'input',
           selector: 'blocklist-form-values-input',
-          value: 'A4370C0CF81686C0B696FA6261c9d3e0d810ae704ab8301839dffd5d5112f476',
+          value:
+            'A4370C0CF81686C0B696FA6261c9d3e0d810ae704ab8301839dffd5d5112f476,aedb279e378BED6C2DB3C9DC9e12ba635e0b391c,741462ab431a22233C787BAAB9B653C7',
         },
         {
           type: 'click',
@@ -379,7 +380,7 @@ export const getArtifactsListTestsData = () => [
         {
           selector: 'blocklistPage-card-criteriaConditions',
           value:
-            'OSIS Windows\nAND file.hash.*IS ONE OF\na4370c0cf81686c0b696fa6261c9d3e0d810ae704ab8301839dffd5d5112f476',
+            'OSIS Windows\nAND file.hash.*IS ONE OF\n741462ab431a22233c787baab9b653c7\naedb279e378bed6c2db3c9dc9e12ba635e0b391c\na4370c0cf81686c0b696fa6261c9d3e0d810ae704ab8301839dffd5d5112f476',
         },
       ],
     },
@@ -408,6 +409,14 @@ export const getArtifactsListTestsData = () => [
           selector:
             'blocklist-form-values-input-a4370c0cf81686c0b696fa6261c9d3e0d810ae704ab8301839dffd5d5112f476',
         },
+        {
+          type: 'clear',
+          selector: 'blocklist-form-values-input-741462ab431a22233c787baab9b653c7',
+        },
+        {
+          type: 'clear',
+          selector: 'blocklist-form-values-input-aedb279e378bed6c2db3c9dc9e12ba635e0b391c',
+        },
         {
           type: 'input',
           selector: 'blocklist-form-values-input',
@@ -449,19 +458,41 @@ export const getArtifactsListTestsData = () => [
         type: 'blocklist',
         identifier: 'endpoint-blocklist-windows-v1',
         relative_url:
-          '/api/fleet/artifacts/endpoint-blocklist-windows-v1/730aee3fea0a4d119285ecec500343262fb9f710915536a901a7b1cec8dff714',
-        body: 'eJxVzM0KgzAQBOB32XORxJ81+ipSZM1uMJCqmFgq0ndvCr2Uuc03zAWypN1LhH64IJ2bQA/RP7YgcPsz5yVwRueDFDPFuYgzlQ3m2brJTmnds/rFhoOFc/s7kxfZNFqKwiMtZ4YnhSPLAFRXrbLKOqPRoFUTdugIS9S240oUG61IWlXTZCqlTdWxc9xwo3Xp6hbh/v7mA+fuPhA=',
+          '/api/fleet/artifacts/endpoint-blocklist-windows-v1/637f1e8795406904980ae2ab4a69cea967756571507f6bd7fc94cde0add20df2',
+        body: 'eJylzsFqwzAMgOF38bkU27Jlu69SQpEtmQTSNCTpWCl595qyy45bj9IvxPdUMm3LIKs6nZ9qe8yiTmodrvMo6vCr1UFGbrEOoxx7WvvjlX27uc2y0HZbWhqmMt5ZuG1/Psk3le1SaBW+0PRo4YvGeytnFZxxaCk7MGStBSghhkyUU0bfBtXt3X74q2ntyXyAIuFsQxIIMQtjsZyhJC5JjM2E4EVnSKb8G2c9fsJzEHTRpUaDEYvOmLASWjQNCaI5Gk0StKMcQZsIiWtlz94YW13AN7vbX9OOoO0=',
         encryption_algorithm: 'none',
         package_name: 'endpoint',
-        encoded_size: 155,
-        encoded_sha256: 'caa472e57d793539061e438337b519367303f4a75adf5a883c4104b88c30ee08',
-        decoded_size: 196,
-        decoded_sha256: '730aee3fea0a4d119285ecec500343262fb9f710915536a901a7b1cec8dff714',
+        encoded_size: 218,
+        encoded_sha256: '751aacf865573055bef82795d23d99b7ab695eb5fb2a36f1231f02f52da8adc0',
+        decoded_size: 501,
+        decoded_sha256: '637f1e8795406904980ae2ab4a69cea967756571507f6bd7fc94cde0add20df2',
         compression_algorithm: 'zlib',
         created: '2000-01-01T00:00:00.000Z',
       }),
       getExpectedUpdatedArtifactBodyWhenCreate: (): ArtifactBodyType => ({
         entries: [
+          {
+            type: 'simple',
+            entries: [
+              {
+                field: 'file.hash.md5',
+                operator: 'included',
+                type: 'exact_cased_any',
+                value: ['741462ab431a22233c787baab9b653c7'],
+              },
+            ],
+          },
+          {
+            type: 'simple',
+            entries: [
+              {
+                field: 'file.hash.sha1',
+                operator: 'included',
+                type: 'exact_cased_any',
+                value: ['aedb279e378bed6c2db3c9dc9e12ba635e0b391c'],
+              },
+            ],
+          },
           {
             type: 'simple',
             entries: [