diff --git a/x-pack/plugins/security_solution/public/management/components/endpoint_responder/command_render_components/integration_tests/isolate_action.test.tsx b/x-pack/plugins/security_solution/public/management/components/endpoint_responder/command_render_components/integration_tests/isolate_action.test.tsx
index e25df018e2bd1..c09807ee2479b 100644
--- a/x-pack/plugins/security_solution/public/management/components/endpoint_responder/command_render_components/integration_tests/isolate_action.test.tsx
+++ b/x-pack/plugins/security_solution/public/management/components/endpoint_responder/command_render_components/integration_tests/isolate_action.test.tsx
@@ -23,7 +23,8 @@ import { ENDPOINT_CAPABILITIES } from '../../../../../../common/endpoint/service
 
 jest.mock('../../../../../common/experimental_features_service');
 
-describe('When using isolate action from response actions console', () => {
+// FLAKY https://github.com/elastic/kibana/issues/145363
+describe.skip('When using isolate action from response actions console', () => {
   let render: (
     capabilities?: EndpointCapabilities[]
   ) => Promise<ReturnType<AppContextTestRender['render']>>;