diff --git a/src/components/datagrid/body/data_grid_row_manager.test.ts b/src/components/datagrid/body/data_grid_row_manager.test.ts
index 047f5f96dce..277d0f320ef 100644
--- a/src/components/datagrid/body/data_grid_row_manager.test.ts
+++ b/src/components/datagrid/body/data_grid_row_manager.test.ts
@@ -150,6 +150,12 @@ describe('row manager', () => {
       expect(row0.classList.contains('world')).toBe(true);
     });
 
+    it('allows passing multiple classes', () => {
+      rerender({ ...mockArgs, rowClasses: { 0: 'hello world' } });
+      expect(getRow(0).classList.contains('hello')).toBe(true);
+      expect(getRow(0).classList.contains('world')).toBe(true);
+    });
+
     it('adds/removes row classes correctly when gridStyle.rowClasses updates', () => {
       rerender({ ...mockArgs, rowClasses: { 1: 'test' } });
       const row0 = getRow(0);
diff --git a/src/components/datagrid/body/data_grid_row_manager.ts b/src/components/datagrid/body/data_grid_row_manager.ts
index b8d1101e2df..05984951216 100644
--- a/src/components/datagrid/body/data_grid_row_manager.ts
+++ b/src/components/datagrid/body/data_grid_row_manager.ts
@@ -30,7 +30,7 @@ export const useRowManager = ({
         rowElement.dataset.gridRowIndex = String(rowIndex); // Row index from data, not affected by sorting/pagination
         rowElement.classList.add('euiDataGridRow');
         if (rowClasses?.[rowIndex]) {
-          rowElement.classList.add(rowClasses[rowIndex]);
+          rowElement.classList.add(...rowClasses[rowIndex].split(' '));
         }
         rowElement.style.position = 'absolute';
         rowElement.style.left = '0';
diff --git a/upcoming_changelogs/7301.md b/upcoming_changelogs/7301.md
index d09c8b9a597..c6e239d6f8b 100644
--- a/upcoming_changelogs/7301.md
+++ b/upcoming_changelogs/7301.md
@@ -2,3 +2,4 @@
 
 - Fixed `EuiDataGrid`s with `gridStyle.stripes` sometimes showing buggy row striping after being sorted
 - Fixed `EuiDataGrid`'s `gridStyle.rowClasses` API to not conflict with `gridStyle.stripes` if dynamically updated
+- Fixed `EuiDataGrid`'s `gridStyle.rowClasses` API to support multiple space-separated classes