diff --git a/easybuild/easyconfigs/m/MATES/MATES-0.1.5-foss-2023b.eb b/easybuild/easyconfigs/m/MATES/MATES-0.1.5-foss-2023b.eb
new file mode 100644
index 00000000000..d142586c26f
--- /dev/null
+++ b/easybuild/easyconfigs/m/MATES/MATES-0.1.5-foss-2023b.eb
@@ -0,0 +1,52 @@
+easyblock = 'PythonBundle'
+
+name = 'MATES'
+version = '0.1.5'
+
+homepage = 'https://github.com/mcgilldinglab/MATES'
+description = "A Deep Learning-Based Model for Quantifying Transposable Elements in Single-Cell Sequencing Data."
+
+toolchain = {'name': 'foss', 'version': '2023b'}
+
+dependencies = [
+    ('Python', '3.11.5'),
+    ('Python-bundle-PyPI', '2023.10'),
+    ('SciPy-bundle', '2023.11'),
+    ('matplotlib', '3.8.2'),
+    ('anndata', '0.11.1'),
+    ('pybedtools', '0.10.0'),
+    ('PyTorch', '2.1.2'),
+    ('Pysam', '0.22.0'),
+    ('tqdm', '4.66.2'),
+    ('SAMtools', '1.19.2'),
+]
+
+use_pip = True
+sanity_pip_check = True
+
+exts_list = [
+    ('sorted_nearest', '0.0.39', {
+        'checksums': ['16a51d5db87ae226b47ace43c176bb672477a1b7ba8052ea9291a6356c9c69b1'],
+    }),
+    ('ncls', '0.0.68', {
+        'checksums': ['81aaa5abb123bb21797ed2f8ef921e20222db14a3ecbc61ccf447532f2b7ba93'],
+    }),
+    ('pyranges', '0.0.129', {
+        'checksums': ['bee83b4fad0062be9586668c6b0fc4270d5e761951975e018202993680071fb3'],
+    }),
+    (name, version, {
+        'source_urls': ['https://github.com/mcgilldinglab/MATES/archive'],
+        'sources': ['v%(version)s.tar.gz'],
+        'checksums': ['be0170d83bf1d039c9de278791e2ad5a61476581c59c245f53ba087b3a5a3407'],
+        # unpin exact versions of dependencies
+        'preinstallopts': """sed -i 's/==.*//g' requirements.txt && sed -i 's/==.*/\",/g' setup.py && """,
+        'modulename': 'MATES',
+    }),
+]
+
+sanity_check_commands = [
+    "python -c 'from MATES import bam_processor, data_processor, MATES_model'",
+    "python -c 'from MATES import TE_quantifier, TE_quantifier_LongRead, TE_quantifier_Intronic'",
+]
+
+moduleclass = 'bio'