diff --git a/.github/workflows/unit-test.yml b/.github/workflows/unit-test.yml
index c60700cfa80..35f3207bd67 100644
--- a/.github/workflows/unit-test.yml
+++ b/.github/workflows/unit-test.yml
@@ -14,10 +14,28 @@ jobs:
     container:
       image: ${{ matrix.container }}
     services:
+      memcached:
+        image: memcached:1.6.9-alpine
+        ports:
+        - 11211:11211
       mongo:
         image: mongo
         ports:
         - 27017:27017
+      mysql:
+        image: circleci/mysql:5.7
+        env:
+          MYSQL_USER: otel
+          MYSQL_PASSWORD: secret
+          MYSQL_DATABASE: circle_database
+          MYSQL_ROOT_PASSWORD: rootpw
+        ports:
+        - 3306:3306
+        options: >-
+          --health-cmd="mysqladmin ping"
+          --health-interval 10s
+          --health-timeout 5s
+          --health-retries 5
       postgres:
         image: circleci/postgres:9.6-alpine
         env:
@@ -39,25 +57,14 @@ jobs:
           --health-interval 10s
           --health-timeout 5s
           --health-retries 5
-      mysql:
-        image: circleci/mysql:5.7
-        env:
-          MYSQL_USER: otel
-          MYSQL_PASSWORD: secret
-          MYSQL_DATABASE: circle_database
-          MYSQL_ROOT_PASSWORD: rootpw
-        ports:
-        - 3306:3306
-        options: >-
-          --health-cmd="mysqladmin ping"
-          --health-interval 10s
-          --health-timeout 5s
-          --health-retries 5
     env:
-      RUN_POSTGRES_TESTS: 1
-      RUN_MYSQL_TESTS: 1
+      RUN_MEMCACHED_TESTS: 1
       RUN_MONGODB_TESTS: 1
+      RUN_MYSQL_TESTS: 1
+      RUN_POSTGRES_TESTS: 1
       RUN_REDIS_TESTS: 1
+      OPENTELEMETRY_MEMCACHED_HOST: memcached
+      OPENTELEMETRY_MEMCACHED_PORT: 11211
       POSTGRES_USER: postgres
       POSTGRES_DB: circle_database
       POSTGRES_HOST: postgres
diff --git a/examples/memcached/README.md b/examples/memcached/README.md
new file mode 100644
index 00000000000..7b535b784bd
--- /dev/null
+++ b/examples/memcached/README.md
@@ -0,0 +1,18 @@
+# Overview
+
+OpenTelemetry Memcached instrumentation allows user to automatically collect trace data from queries made by the client and export them to the backend of choice. This example does not showcase export functionality, but there are numerous other examples doing that: [`express`](../express), [`router`](../router).
+
+## Running the Example
+
+Created spans are printed out to stdout while running the example.
+
+```sh
+npm install # install the dependencies
+npm run docker:start # start memcached server
+npm run start # run the example
+npm run docker:stop # spin down and clean up the docker container
+```
+
+## LICENSE
+
+Apache License 2.0
diff --git a/examples/memcached/index.js b/examples/memcached/index.js
new file mode 100644
index 00000000000..d25c2bc0db4
--- /dev/null
+++ b/examples/memcached/index.js
@@ -0,0 +1,20 @@
+'use strict';
+
+require('./tracer')('example-resource');
+const Memcached = require('memcached');
+const assert = require('assert');
+
+const KEY = '_KEY_';
+const VALUE = `RAND:${Math.random().toFixed(4)}`;
+const LT = 10;
+const client = new Memcached();
+
+client.set(KEY, VALUE, LT, (err) => {
+  assert.strictEqual(err, undefined);
+  client.get(KEY, (err, result) => {
+    assert.strictEqual(err, undefined);
+    assert.strictEqual(result, VALUE);
+    console.log('Sleeping 5 seconds before shutdown to ensure all records are flushed.');
+    setTimeout(() => { console.log('Completed.'); }, 5000);
+  });
+});
diff --git a/examples/memcached/package.json b/examples/memcached/package.json
new file mode 100644
index 00000000000..471ae56dbe6
--- /dev/null
+++ b/examples/memcached/package.json
@@ -0,0 +1,39 @@
+{
+  "name": "memcached-example",
+  "private": true,
+  "version": "0.22.0",
+  "description": "Example of Memcached client with OpenTelemetry",
+  "main": "index.js",
+  "scripts": {
+    "docker:start": "docker run --rm -d --name otel-memcached -p 11211:11211 memcached:1.6.9-alpine",
+    "docker:stop": "docker rm -f otel-memcached",
+    "start": "node index.js"
+  },
+  "repository": {
+    "type": "git",
+    "url": "git+ssh://git@github.com/open-telemetry/opentelemetry-js-contrib.git"
+  },
+  "keywords": [
+    "opentelemetry",
+    "instrumentation",
+    "memcached",
+    "tracing"
+  ],
+  "engines": {
+    "node": ">=8.5.0"
+  },
+  "author": "OpenTelemetry Authors",
+  "license": "Apache-2.0",
+  "bugs": {
+    "url": "https://github.com/open-telemetry/opentelemetry-js-contrib/issues"
+  },
+  "dependencies": {
+    "@opentelemetry/api": "^1.0.1",
+    "@opentelemetry/instrumentation": "^0.22.0",
+    "@opentelemetry/instrumentation-memcached": "^0.22.0",
+    "@opentelemetry/node": "^0.22.0",
+    "@opentelemetry/tracing": "^0.22.0",
+    "memcached": "^2.2.2"
+  },
+  "homepage": "https://github.com/open-telemetry/opentelemetry-js-contrib#readme"
+}
diff --git a/examples/memcached/tracer.js b/examples/memcached/tracer.js
new file mode 100644
index 00000000000..b86bceb967c
--- /dev/null
+++ b/examples/memcached/tracer.js
@@ -0,0 +1,37 @@
+'use strict';
+
+const opentelemetry = require('@opentelemetry/api');
+
+const { diag, DiagConsoleLogger, DiagLogLevel } = opentelemetry;
+diag.setLogger(new DiagConsoleLogger(), DiagLogLevel.VERBOSE);
+
+const { registerInstrumentations } = require('@opentelemetry/instrumentation');
+const { NodeTracerProvider } = require('@opentelemetry/node');
+const { SimpleSpanProcessor, ConsoleSpanExporter } = require('@opentelemetry/tracing');
+const { Resource } = require('@opentelemetry/resources');
+const { ResourceAttributes } = require('@opentelemetry/semantic-conventions');
+
+const { MemcachedInstrumentation } = require('@opentelemetry/instrumentation-memcached');
+
+module.exports = (serviceName) => {
+  const provider = new NodeTracerProvider({
+    resource: new Resource({
+      [ResourceAttributes.SERVICE_NAME]: serviceName,
+    }),
+  });
+  registerInstrumentations({
+    tracerProvider: provider,
+    instrumentations: [
+      new MemcachedInstrumentation(),
+    ],
+  });
+
+  const exporter = new ConsoleSpanExporter();
+
+  provider.addSpanProcessor(new SimpleSpanProcessor(exporter));
+
+  // Initialize the OpenTelemetry APIs to use the NodeTracerProvider bindings
+  provider.register();
+
+  return opentelemetry.trace.getTracer('memcached-example');
+};
diff --git a/packages/opentelemetry-test-utils/testUtils.ts b/packages/opentelemetry-test-utils/testUtils.ts
index 48abc13b514..387b0502eba 100644
--- a/packages/opentelemetry-test-utils/testUtils.ts
+++ b/packages/opentelemetry-test-utils/testUtils.ts
@@ -29,23 +29,18 @@ import {
   hrTimeToMicroseconds,
 } from '@opentelemetry/core';
 
-export function startDocker(db: 'redis' | 'mysql' | 'postgres') {
-  let dockerRunCmd;
-  switch (db) {
-    case 'redis':
-      dockerRunCmd = `docker run -d -p 63790:6379 --name ot${db} ${db}:alpine`;
-      break;
-
-    case 'mysql':
-      dockerRunCmd = `docker run --rm -d -e MYSQL_ROOT_PASSWORD=rootpw -e MYSQL_DATABASE=test_db -e MYSQL_USER=otel -e MYSQL_PASSWORD=secret -p 33306:3306 --name ot${db} circleci/${db}:5.7`;
-      break;
-
-    case 'postgres':
-      dockerRunCmd = `docker run -d -p 54320:5432 -e POSTGRES_PASSWORD=postgres --name ot${db} ${db}:alpine`;
-      break;
-  }
+const dockerRunCmds = {
+  redis: 'docker run --rm -d --name otel-redis -p 63790:6379 redis:alpine',
+  mysql:
+    'docker run --rm -d --name otel-mysql -p 33306:3306 -e MYSQL_ROOT_PASSWORD=rootpw -e MYSQL_DATABASE=test_db -e MYSQL_USER=otel -e MYSQL_PASSWORD=secret circleci/mysql:5.7',
+  postgres:
+    'docker run --rm -d --name otel-postgres -p 54320:5432 -e POSTGRES_PASSWORD=postgres postgres:alpine',
+  memcached:
+    'docker run --rm -d --name otel-memcached -p 11211:11211 memcached:1.6.9-alpine',
+};
 
-  const tasks = [run(dockerRunCmd)];
+export function startDocker(db: keyof typeof dockerRunCmds) {
+  const tasks = [run(dockerRunCmds[db])];
 
   for (let i = 0; i < tasks.length; i++) {
     const task = tasks[i];
@@ -58,9 +53,9 @@ export function startDocker(db: 'redis' | 'mysql' | 'postgres') {
   return true;
 }
 
-export function cleanUpDocker(db: 'redis' | 'mysql' | 'postgres') {
-  run(`docker stop ot${db}`);
-  run(`docker rm ot${db}`);
+export function cleanUpDocker(db: keyof typeof dockerRunCmds) {
+  run(`docker stop otel-${db}`);
+  run(`docker rm otel-${db}`);
 }
 
 function run(cmd: string) {
diff --git a/plugins/node/opentelemetry-instrumentation-memcached/.eslintignore b/plugins/node/opentelemetry-instrumentation-memcached/.eslintignore
new file mode 100644
index 00000000000..378eac25d31
--- /dev/null
+++ b/plugins/node/opentelemetry-instrumentation-memcached/.eslintignore
@@ -0,0 +1 @@
+build
diff --git a/plugins/node/opentelemetry-instrumentation-memcached/.eslintrc.js b/plugins/node/opentelemetry-instrumentation-memcached/.eslintrc.js
new file mode 100644
index 00000000000..f756f4488b2
--- /dev/null
+++ b/plugins/node/opentelemetry-instrumentation-memcached/.eslintrc.js
@@ -0,0 +1,7 @@
+module.exports = {
+    "env": {
+        "mocha": true,
+        "node": true
+    },
+    ...require('../../../eslint.config.js')
+}
diff --git a/plugins/node/opentelemetry-instrumentation-memcached/.npmignore b/plugins/node/opentelemetry-instrumentation-memcached/.npmignore
new file mode 100644
index 00000000000..9505ba9450f
--- /dev/null
+++ b/plugins/node/opentelemetry-instrumentation-memcached/.npmignore
@@ -0,0 +1,4 @@
+/bin
+/coverage
+/doc
+/test
diff --git a/plugins/node/opentelemetry-instrumentation-memcached/LICENSE b/plugins/node/opentelemetry-instrumentation-memcached/LICENSE
new file mode 100644
index 00000000000..261eeb9e9f8
--- /dev/null
+++ b/plugins/node/opentelemetry-instrumentation-memcached/LICENSE
@@ -0,0 +1,201 @@
+                                 Apache License
+                           Version 2.0, January 2004
+                        http://www.apache.org/licenses/
+
+   TERMS AND CONDITIONS FOR USE, REPRODUCTION, AND DISTRIBUTION
+
+   1. Definitions.
+
+      "License" shall mean the terms and conditions for use, reproduction,
+      and distribution as defined by Sections 1 through 9 of this document.
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+      "Legal Entity" shall mean the union of the acting entity and all
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+      direction or management of such entity, whether by contract or
+      otherwise, or (ii) ownership of fifty percent (50%) or more of the
+      outstanding shares, or (iii) beneficial ownership of such entity.
+
+      "You" (or "Your") shall mean an individual or Legal Entity
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+
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+
+      "Work" shall mean the work of authorship, whether in Source or
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+      "Contribution" shall mean any work of authorship, including
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+   5. Submission of Contributions. Unless You explicitly state otherwise,
+      any Contribution intentionally submitted for inclusion in the Work
+      by You to the Licensor shall be under the terms and conditions of
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+      unless required by applicable law (such as deliberate and grossly
+      negligent acts) or agreed to in writing, shall any Contributor be
+      liable to You for damages, including any direct, indirect, special,
+      incidental, or consequential damages of any character arising as a
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+      Work (including but not limited to damages for loss of goodwill,
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+      has been advised of the possibility of such damages.
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+      on Your own behalf and on Your sole responsibility, not on behalf
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+   Unless required by applicable law or agreed to in writing, software
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diff --git a/plugins/node/opentelemetry-instrumentation-memcached/README.md b/plugins/node/opentelemetry-instrumentation-memcached/README.md
new file mode 100644
index 00000000000..983105f151f
--- /dev/null
+++ b/plugins/node/opentelemetry-instrumentation-memcached/README.md
@@ -0,0 +1,72 @@
+# OpenTelemetry Memcached Instrumentation for Node.js
+
+[![NPM Published Version][npm-img]][npm-url]
+[![dependencies][dependencies-image]][dependencies-url]
+[![devDependencies][devDependencies-image]][devDependencies-url]
+[![Apache License][license-image]][license-image]
+
+This module provides automatic instrumentation for [`memcached@>=2.2.0`][repo-url].
+
+For automatic instrumentation see the
+[@opentelemetry/node](https://github.com/open-telemetry/opentelemetry-js/tree/main/packages/opentelemetry-node) package.
+
+## Installation
+
+```bash
+npm install --save @opentelemetry/instrumentation-memcached
+```
+
+### Supported Versions
+
+- `>=2.2`
+
+## Usage
+
+OpenTelemetry Memcached Instrumentation allows the user to automatically collect trace data and export them to the backend of choice, to give observability to distributed systems when working with [memcached][pkg-url].
+
+To load a specific instrumentation (**memcached** in this case), specify it in the registerInstrumentations' configuration
+
+```javascript
+const { NodeTracerProvider } = require('@opentelemetry/node');
+const { MemcachedInstrumentation } = require('@opentelemetry/instrumentation-memcached');
+const { registerInstrumentations } = require('@opentelemetry/instrumentation');
+
+const provider = new NodeTracerProvider();
+provider.register();
+
+registerInstrumentations({
+  instrumentations: [
+    new MemcachedInstrumentation({
+      enhancedDatabaseReporting: false,
+    }),
+  ],
+});
+```
+
+### Configuration Options
+
+| Option | Type | Example | Description |
+| ------- | ---- | ------- | ----------- |
+| `enhancedDatabaseReporting` | `boolean` | `false` | Include full command statement in the span - **leaks potentially sensitive information to your spans**. Defaults to `false`. |
+
+## Useful links
+
+- For more information on OpenTelemetry, visit: <https://opentelemetry.io/>
+- For more about OpenTelemetry JavaScript: <https://github.com/open-telemetry/opentelemetry-js>
+- For help or feedback on this project, join us in [GitHub Discussions][discussions-url]
+
+## License
+
+Apache 2.0 - See [LICENSE][license-url] for more information.
+
+[discussions-url]: https://github.com/open-telemetry/opentelemetry-js/discussions
+[license-url]: https://github.com/open-telemetry/opentelemetry-js-contrib/blob/main/LICENSE
+[license-image]: https://img.shields.io/badge/license-Apache_2.0-green.svg?style=flat
+[dependencies-image]: https://status.david-dm.org/gh/open-telemetry/opentelemetry-js-contrib.svg?path=plugins%2Fnode%2Fopentelemetry-instrumentation-memcached
+[dependencies-url]: https://david-dm.org/open-telemetry/opentelemetry-js-contrib?path=plugins%2Fnode%2Fopentelemetry-instrumentation-memcached
+[devDependencies-image]: https://status.david-dm.org/gh/open-telemetry/opentelemetry-js-contrib.svg?path=plugins%2Fnode%2Fopentelemetry-instrumentation-memcached&type=dev
+[devDependencies-url]: https://david-dm.org/open-telemetry/opentelemetry-js-contrib?path=plugins%2Fnode%2Fopentelemetry-instrumentation-memcached&type=dev
+[npm-url]: https://www.npmjs.com/package/@opentelemetry/instrumentation-memcached
+[npm-img]: https://badge.fury.io/js/%40opentelemetry%2Finstrumentation-memcached.svg
+[repo-url]: https://github.com/3rd-Eden/memcached
+[pkg-url]: https://www.npmjs.com/package/memcached
diff --git a/plugins/node/opentelemetry-instrumentation-memcached/package.json b/plugins/node/opentelemetry-instrumentation-memcached/package.json
new file mode 100644
index 00000000000..57829ead894
--- /dev/null
+++ b/plugins/node/opentelemetry-instrumentation-memcached/package.json
@@ -0,0 +1,71 @@
+{
+  "name": "@opentelemetry/instrumentation-memcached",
+  "version": "0.22.0",
+  "description": "OpenTelemetry memcached automatic instrumentation package.",
+  "main": "build/src/index.js",
+  "types": "build/src/index.d.ts",
+  "repository": "open-telemetry/opentelemetry-js-contrib",
+  "scripts": {
+    "clean": "rimraf build/*",
+    "codecov": "nyc report --reporter=json && codecov -f coverage/*.json -p ../../",
+    "compile": "npm run version:update && tsc -p .",
+    "lint": "eslint . --ext .ts",
+    "lint:fix": "eslint . --ext .ts --fix",
+    "precompile": "tsc --version",
+    "prepare": "npm run compile",
+    "tdd": "npm run test -- --watch-extensions ts --watch",
+    "test": "nyc ts-mocha -p tsconfig.json 'test/**/*.test.ts'",
+    "test:debug": "cross-env RUN_MEMCACHED_TESTS_LOCAL=true ts-mocha --inspect-brk --no-timeouts -p tsconfig.json 'test/**/*.test.ts'",
+    "test:local": "cross-env RUN_MEMCACHED_TESTS_LOCAL=true npm run test",
+    "version:update": "node ../../../scripts/version-update.js"
+  },
+  "keywords": [
+    "opentelemetry",
+    "memcached",
+    "nodejs",
+    "tracing",
+    "profiling",
+    "instrumentation"
+  ],
+  "author": "OpenTelemetry Authors",
+  "license": "Apache-2.0",
+  "engines": {
+    "node": ">=8.0.0"
+  },
+  "files": [
+    "build/src/**/*.js",
+    "build/src/**/*.d.ts",
+    "doc",
+    "LICENSE",
+    "README.md"
+  ],
+  "publishConfig": {
+    "access": "public"
+  },
+  "peerDependencies": {
+    "@opentelemetry/api": "^1.0.1"
+  },
+  "devDependencies": {
+    "@opentelemetry/api": "1.0.1",
+    "@opentelemetry/context-async-hooks": "0.22.0",
+    "@opentelemetry/node": "0.22.0",
+    "@opentelemetry/test-utils": "^0.22.0",
+    "@opentelemetry/tracing": "0.22.0",
+    "@types/mocha": "7.0.2",
+    "@types/node": "14.17.2",
+    "codecov": "3.8.2",
+    "cross-env": "7.0.3",
+    "gts": "3.1.0",
+    "memcached": "^2.2.2",
+    "mocha": "7.2.0",
+    "nyc": "15.1.0",
+    "rimraf": "3.0.2",
+    "ts-mocha": "8.0.0",
+    "typescript": "4.3.2"
+  },
+  "dependencies": {
+    "@opentelemetry/instrumentation": "^0.22.0",
+    "@opentelemetry/semantic-conventions": "^0.22.0",
+    "@types/memcached": "^2.2.6"
+  }
+}
diff --git a/plugins/node/opentelemetry-instrumentation-memcached/src/index.ts b/plugins/node/opentelemetry-instrumentation-memcached/src/index.ts
new file mode 100644
index 00000000000..4c831c2980e
--- /dev/null
+++ b/plugins/node/opentelemetry-instrumentation-memcached/src/index.ts
@@ -0,0 +1,22 @@
+/*
+ * Copyright The OpenTelemetry Authors
+ *
+ * Licensed under the Apache License, Version 2.0 (the "License");
+ * you may not use this file except in compliance with the License.
+ * You may obtain a copy of the License at
+ *
+ *      https://www.apache.org/licenses/LICENSE-2.0
+ *
+ * Unless required by applicable law or agreed to in writing, software
+ * distributed under the License is distributed on an "AS IS" BASIS,
+ * WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied.
+ * See the License for the specific language governing permissions and
+ * limitations under the License.
+ */
+
+import { Instrumentation } from './instrumentation';
+export { InstrumentationConfig } from './types';
+
+export * from './instrumentation';
+export default Instrumentation;
+export { Instrumentation as MemcachedInstrumentation };
diff --git a/plugins/node/opentelemetry-instrumentation-memcached/src/instrumentation.ts b/plugins/node/opentelemetry-instrumentation-memcached/src/instrumentation.ts
new file mode 100644
index 00000000000..4bc30e87df5
--- /dev/null
+++ b/plugins/node/opentelemetry-instrumentation-memcached/src/instrumentation.ts
@@ -0,0 +1,188 @@
+/*
+ * Copyright The OpenTelemetry Authors
+ *
+ * Licensed under the Apache License, Version 2.0 (the "License");
+ * you may not use this file except in compliance with the License.
+ * You may obtain a copy of the License at
+ *
+ *      https://www.apache.org/licenses/LICENSE-2.0
+ *
+ * Unless required by applicable law or agreed to in writing, software
+ * distributed under the License is distributed on an "AS IS" BASIS,
+ * WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied.
+ * See the License for the specific language governing permissions and
+ * limitations under the License.
+ */
+
+import * as api from '@opentelemetry/api';
+import {
+  isWrapped,
+  InstrumentationBase,
+  InstrumentationNodeModuleDefinition,
+} from '@opentelemetry/instrumentation';
+import type * as Memcached from 'memcached';
+import { SemanticAttributes } from '@opentelemetry/semantic-conventions';
+import * as utils from './utils';
+import { InstrumentationConfig } from './types';
+import { VERSION } from './version';
+
+export class Instrumentation extends InstrumentationBase<typeof Memcached> {
+  static readonly COMPONENT = 'memcached';
+  static readonly COMMON_ATTRIBUTES = {
+    [SemanticAttributes.DB_SYSTEM]: Instrumentation.COMPONENT,
+  };
+  static readonly DEFAULT_CONFIG: InstrumentationConfig = {
+    enhancedDatabaseReporting: false,
+  };
+
+  constructor(config: InstrumentationConfig = {}) {
+    super(
+      '@opentelemetry/instrumentation-memcached',
+      VERSION,
+      Object.assign({}, Instrumentation.DEFAULT_CONFIG, config)
+    );
+  }
+
+  setConfig(config: InstrumentationConfig = {}) {
+    this._config = Object.assign({}, Instrumentation.DEFAULT_CONFIG, config);
+  }
+
+  init() {
+    return [
+      new InstrumentationNodeModuleDefinition<typeof Memcached>(
+        'memcached',
+        ['>=2.2'],
+        (moduleExports, moduleVersion) => {
+          this._diag.debug(
+            `Patching ${Instrumentation.COMPONENT}@${moduleVersion}`
+          );
+          this.ensureWrapped(
+            moduleVersion,
+            moduleExports.prototype,
+            'command',
+            this.wrapCommand.bind(this, moduleVersion)
+          );
+          return moduleExports;
+        },
+        (moduleExports, moduleVersion) => {
+          this._diag.debug(
+            `Unpatching ${Instrumentation.COMPONENT}@${moduleVersion}`
+          );
+          if (moduleExports === undefined) return;
+          // `command` is documented API missing from the types
+          this._unwrap(moduleExports.prototype, 'command' as keyof Memcached);
+        }
+      ),
+    ];
+  }
+
+  wrapCommand(
+    moduleVersion: undefined | string,
+    original: (
+      queryCompiler: () => Memcached.CommandData,
+      server?: string
+    ) => any
+  ) {
+    const instrumentation = this;
+    return function (
+      this: Memcached,
+      queryCompiler: () => Memcached.CommandData,
+      server?: string
+    ) {
+      if (typeof queryCompiler !== 'function') {
+        return original.apply(this, arguments as any);
+      }
+      // The name will be overwritten later
+      const span = instrumentation.tracer.startSpan(
+        'unknown memcached command',
+        {
+          kind: api.SpanKind.CLIENT,
+          attributes: {
+            'memcached.version': moduleVersion,
+            ...Instrumentation.COMMON_ATTRIBUTES,
+          },
+        }
+      );
+      const parentContext = api.context.active();
+      const context = api.trace.setSpan(parentContext, span);
+
+      return api.context.with(
+        context,
+        original,
+        this,
+        instrumentation.wrapQueryCompiler.call(
+          instrumentation,
+          queryCompiler,
+          this,
+          server,
+          parentContext,
+          span
+        ),
+        server
+      );
+    };
+  }
+
+  wrapQueryCompiler(
+    original: () => Memcached.CommandData,
+    client: Memcached,
+    server: undefined | string,
+    callbackContext: api.Context,
+    span: api.Span
+  ) {
+    const instrumentation = this;
+    return function (this: Memcached) {
+      const query = original.apply(this, arguments as any);
+      const callback = query.callback;
+
+      span.updateName(`${query.type} ${query.key}`);
+      span.setAttributes({
+        'db.memcached.key': query.key,
+        'db.memcached.lifetime': query.lifetime,
+        [SemanticAttributes.DB_OPERATION]: query.type,
+        [SemanticAttributes.DB_STATEMENT]: (
+          instrumentation._config as InstrumentationConfig
+        ).enhancedDatabaseReporting
+          ? query.command
+          : undefined,
+        ...utils.getPeerAttributes(client, server, query),
+      });
+
+      query.callback = api.context.bind(
+        callbackContext,
+        function (this: Memcached.CommandData, err: any) {
+          if (err) {
+            span.recordException(err);
+            span.setStatus({
+              code: api.SpanStatusCode.ERROR,
+              message: err.message,
+            });
+          }
+
+          span.end();
+
+          if (typeof callback === 'function') {
+            return callback.apply(this, arguments as any);
+          }
+        }
+      );
+
+      return query;
+    };
+  }
+
+  private ensureWrapped(
+    moduleVersion: string | undefined,
+    obj: any,
+    methodName: string,
+    wrapper: (original: any) => any
+  ) {
+    this._diag.debug(
+      `Applying ${methodName} patch for ${Instrumentation.COMPONENT}@${moduleVersion}`
+    );
+    if (isWrapped(obj[methodName])) {
+      this._unwrap(obj, methodName);
+    }
+    this._wrap(obj, methodName, wrapper);
+  }
+}
diff --git a/plugins/node/opentelemetry-instrumentation-memcached/src/types.ts b/plugins/node/opentelemetry-instrumentation-memcached/src/types.ts
new file mode 100644
index 00000000000..b2b395f0692
--- /dev/null
+++ b/plugins/node/opentelemetry-instrumentation-memcached/src/types.ts
@@ -0,0 +1,21 @@
+/*
+ * Copyright The OpenTelemetry Authors
+ *
+ * Licensed under the Apache License, Version 2.0 (the "License");
+ * you may not use this file except in compliance with the License.
+ * You may obtain a copy of the License at
+ *
+ *      https://www.apache.org/licenses/LICENSE-2.0
+ *
+ * Unless required by applicable law or agreed to in writing, software
+ * distributed under the License is distributed on an "AS IS" BASIS,
+ * WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied.
+ * See the License for the specific language governing permissions and
+ * limitations under the License.
+ */
+
+import { InstrumentationConfig as BaseInstrumentationConfig } from '@opentelemetry/instrumentation';
+
+export interface InstrumentationConfig extends BaseInstrumentationConfig {
+  enhancedDatabaseReporting?: boolean;
+}
diff --git a/plugins/node/opentelemetry-instrumentation-memcached/src/utils.ts b/plugins/node/opentelemetry-instrumentation-memcached/src/utils.ts
new file mode 100644
index 00000000000..aa49f6c357b
--- /dev/null
+++ b/plugins/node/opentelemetry-instrumentation-memcached/src/utils.ts
@@ -0,0 +1,54 @@
+/*
+ * Copyright The OpenTelemetry Authors
+ *
+ * Licensed under the Apache License, Version 2.0 (the "License");
+ * you may not use this file except in compliance with the License.
+ * You may obtain a copy of the License at
+ *
+ *      https://www.apache.org/licenses/LICENSE-2.0
+ *
+ * Unless required by applicable law or agreed to in writing, software
+ * distributed under the License is distributed on an "AS IS" BASIS,
+ * WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied.
+ * See the License for the specific language governing permissions and
+ * limitations under the License.
+ */
+
+import type * as Memcached from 'memcached';
+import { SemanticAttributes } from '@opentelemetry/semantic-conventions';
+
+export const getPeerAttributes = (
+  client: any /* Memcached, but the type definitions are lacking */,
+  server: string | undefined,
+  query: Memcached.CommandData
+) => {
+  if (!server) {
+    if (client.servers.length === 1) {
+      server = client.servers[0];
+    } else {
+      let redundancy =
+        client.redundancy && client.redundancy < client.servers.length;
+      const queryRedundancy = query.redundancyEnabled;
+
+      if (redundancy && queryRedundancy) {
+        redundancy = client.HashRing.range(
+          query.key,
+          client.redundancy + 1,
+          true
+        );
+        server = redundancy.shift();
+      } else {
+        server = client.HashRing.get(query.key);
+      }
+    }
+  }
+
+  if (typeof server === 'string') {
+    const [host, port] = server && server.split(':');
+    return {
+      [SemanticAttributes.NET_PEER_NAME]: host,
+      [SemanticAttributes.NET_PEER_PORT]: port,
+    };
+  }
+  return {};
+};
diff --git a/plugins/node/opentelemetry-instrumentation-memcached/src/version.ts b/plugins/node/opentelemetry-instrumentation-memcached/src/version.ts
new file mode 100644
index 00000000000..8b92491b988
--- /dev/null
+++ b/plugins/node/opentelemetry-instrumentation-memcached/src/version.ts
@@ -0,0 +1,18 @@
+/*
+ * Copyright The OpenTelemetry Authors
+ *
+ * Licensed under the Apache License, Version 2.0 (the "License");
+ * you may not use this file except in compliance with the License.
+ * You may obtain a copy of the License at
+ *
+ *      https://www.apache.org/licenses/LICENSE-2.0
+ *
+ * Unless required by applicable law or agreed to in writing, software
+ * distributed under the License is distributed on an "AS IS" BASIS,
+ * WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied.
+ * See the License for the specific language governing permissions and
+ * limitations under the License.
+ */
+
+// this is autogenerated file, see scripts/version-update.js
+export const VERSION = '0.22.0';
diff --git a/plugins/node/opentelemetry-instrumentation-memcached/test/index.test.ts b/plugins/node/opentelemetry-instrumentation-memcached/test/index.test.ts
new file mode 100644
index 00000000000..ca6c54b3ade
--- /dev/null
+++ b/plugins/node/opentelemetry-instrumentation-memcached/test/index.test.ts
@@ -0,0 +1,310 @@
+/*
+ * Copyright The OpenTelemetry Authors
+ *
+ * Licensed under the Apache License, Version 2.0 (the "License");
+ * you may not use this file except in compliance with the License.
+ * You may obtain a copy of the License at
+ *
+ *      https://www.apache.org/licenses/LICENSE-2.0
+ *
+ * Unless required by applicable law or agreed to in writing, software
+ * distributed under the License is distributed on an "AS IS" BASIS,
+ * WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied.
+ * See the License for the specific language governing permissions and
+ * limitations under the License.
+ */
+
+import { context, SpanKind, SpanStatusCode, trace } from '@opentelemetry/api';
+import { NodeTracerProvider } from '@opentelemetry/node';
+import { AsyncHooksContextManager } from '@opentelemetry/context-async-hooks';
+import * as testUtils from '@opentelemetry/test-utils';
+import {
+  InMemorySpanExporter,
+  SimpleSpanProcessor,
+} from '@opentelemetry/tracing';
+import type * as Memcached from 'memcached';
+import * as assert from 'assert';
+import Instrumentation from '../src';
+import { SemanticAttributes } from '@opentelemetry/semantic-conventions';
+import * as util from 'util';
+
+const instrumentation = new Instrumentation();
+const memoryExporter = new InMemorySpanExporter();
+
+const CONFIG = {
+  host: process.env.OPENTELEMETRY_MEMCACHED_HOST || 'localhost',
+  port: process.env.OPENTELEMETRY_MEMCACHED_PORT || '11211',
+};
+
+const DEFAULT_ATTRIBUTES = {
+  [SemanticAttributes.DB_SYSTEM]: Instrumentation.COMPONENT,
+  [SemanticAttributes.NET_PEER_NAME]: CONFIG.host,
+  [SemanticAttributes.NET_PEER_PORT]: CONFIG.port,
+};
+
+interface ExtendedMemcached extends Memcached {
+  getPromise: (key: string) => Promise<unknown>;
+  setPromise: (key: string, value: any, lifetime: number) => Promise<unknown>;
+  appendPromise: (key: string, value: any) => Promise<unknown>;
+}
+const getClient = (...args: any[]): ExtendedMemcached => {
+  const Memcached = require('memcached');
+  const client = new Memcached(...args);
+  client.getPromise = util.promisify(client.get.bind(client));
+  client.setPromise = util.promisify(client.set.bind(client));
+  client.appendPromise = util.promisify(client.append.bind(client));
+  return client;
+};
+const KEY = 'foo';
+const VALUE = '_test_value_';
+const shouldTestLocal = process.env.RUN_MEMCACHED_TESTS_LOCAL;
+const shouldTest = process.env.RUN_MEMCACHED_TESTS || shouldTestLocal;
+
+describe('memcached@2.x', () => {
+  const provider = new NodeTracerProvider();
+  const tracer = provider.getTracer('default');
+  provider.addSpanProcessor(new SimpleSpanProcessor(memoryExporter));
+  instrumentation.setTracerProvider(provider);
+  let contextManager: AsyncHooksContextManager;
+
+  beforeEach(() => {
+    contextManager = new AsyncHooksContextManager();
+    context.setGlobalContextManager(contextManager.enable());
+    instrumentation.setConfig({});
+    instrumentation.enable();
+  });
+
+  afterEach(() => {
+    memoryExporter.reset();
+    context.disable();
+    instrumentation.disable();
+  });
+
+  before(function () {
+    // needs to be "function" to have MochaContext "this" context
+    if (!shouldTest) {
+      // this.skip() workaround
+      // https://github.com/mochajs/mocha/issues/2683#issuecomment-375629901
+      this.test!.parent!.pending = true;
+      this.skip();
+    }
+
+    if (shouldTestLocal) {
+      testUtils.startDocker('memcached');
+    }
+  });
+
+  after(() => {
+    if (shouldTestLocal) {
+      testUtils.cleanUpDocker('memcached');
+    }
+  });
+
+  describe('default config', () => {
+    let client: ExtendedMemcached;
+    beforeEach(() => {
+      client = getClient(`${CONFIG.host}:${CONFIG.port}`, { retries: 0 });
+    });
+
+    afterEach(() => {
+      client.end();
+    });
+
+    it('should collect basic info', async () => {
+      const parentSpan = tracer.startSpan('parentSpan');
+
+      await context.with(
+        trace.setSpan(context.active(), parentSpan),
+        async () => {
+          await client.setPromise(KEY, VALUE, 10);
+          const value = await client.getPromise(KEY);
+
+          assert.strictEqual(value, VALUE);
+          const instrumentationSpans = memoryExporter.getFinishedSpans();
+          assertSpans(instrumentationSpans, [
+            {
+              op: 'set',
+              key: KEY,
+              parentSpan,
+            },
+            {
+              op: 'get',
+              key: KEY,
+              parentSpan,
+            },
+          ]);
+        }
+      );
+    });
+
+    it('should handle errors', async () => {
+      const parentSpan = tracer.startSpan('parentSpan');
+      const KEY = 'unset_key';
+      const neverError = new Error('Expected to error but did not');
+
+      await context.with(
+        trace.setSpan(context.active(), parentSpan),
+        async () => {
+          try {
+            await client.appendPromise(KEY, VALUE);
+            assert.fail(neverError);
+          } catch (e) {
+            assert.notStrictEqual(e, neverError);
+          }
+
+          const instrumentationSpans = memoryExporter.getFinishedSpans();
+          assertSpans(instrumentationSpans, [
+            {
+              op: 'append',
+              key: KEY,
+              parentSpan,
+              status: {
+                code: SpanStatusCode.ERROR,
+                message: 'Item is not stored',
+              },
+            },
+          ]);
+
+          assertMatch(
+            instrumentationSpans?.[0]?.events[0]?.attributes?.[
+              SemanticAttributes.EXCEPTION_MESSAGE
+            ] as 'string',
+            /not stored/
+          );
+        }
+      );
+    });
+
+    it('should not require callback to be present', done => {
+      // want to force an signature without the callback
+      (client.get as any)(KEY);
+
+      setTimeout(() => {
+        try {
+          const instrumentationSpans = memoryExporter.getFinishedSpans();
+          assertSpans(instrumentationSpans, [
+            {
+              op: 'get',
+              key: KEY,
+            },
+          ]);
+          done();
+        } catch (e) {
+          done(e);
+        }
+      }, 25);
+    });
+
+    it('should return to parent context in callback', done => {
+      const parentSpan = tracer.startSpan('parentSpan');
+      const parentContext = trace.setSpan(context.active(), parentSpan);
+
+      context.with(parentContext, () => {
+        client.get(KEY, () => {
+          try {
+            const cbContext = context.active();
+            assert.strictEqual(cbContext, parentContext);
+            done();
+          } catch (e) {
+            done(e);
+          }
+        });
+      });
+    });
+
+    it('should collect be able to collect statements', async () => {
+      instrumentation.setConfig({
+        enhancedDatabaseReporting: true,
+      });
+      const value = await client.getPromise(KEY);
+
+      assert.strictEqual(value, VALUE);
+      const instrumentationSpans = memoryExporter.getFinishedSpans();
+      assertSpans(instrumentationSpans, [
+        {
+          op: 'get',
+          key: KEY,
+          statement: 'get foo',
+        },
+      ]);
+    });
+
+    it('should not create new spans when disabled', async () => {
+      instrumentation.disable();
+      await client.getPromise(KEY);
+      assert.strictEqual(memoryExporter.getFinishedSpans().length, 0);
+    });
+  });
+
+  describe('alternate memcached configurations', () => {
+    it('should support multiple server configuration', async () => {
+      const client = getClient(
+        {
+          [`${CONFIG.host}:${CONFIG.port}`]: 1,
+          'other:11211': 1,
+        },
+        { retries: 0 }
+      );
+
+      await Promise.all([client.getPromise(KEY)]);
+
+      const instrumentationSpans = memoryExporter.getFinishedSpans();
+      assertSpans(instrumentationSpans, [
+        {
+          op: 'get',
+          key: KEY,
+        },
+      ]);
+    });
+  });
+});
+
+const assertSpans = (actualSpans: any[], expectedSpans: any[]) => {
+  assert(Array.isArray(actualSpans), 'Expected `actualSpans` to be an array');
+  assert(
+    Array.isArray(expectedSpans),
+    'Expected `expectedSpans` to be an array'
+  );
+  assert.strictEqual(
+    actualSpans.length,
+    expectedSpans.length,
+    'Expected span count different from actual'
+  );
+  actualSpans.forEach((span, idx) => {
+    const expected = expectedSpans[idx];
+    if (expected === null) return;
+    try {
+      assert.notStrictEqual(span, undefined);
+      assert.notStrictEqual(expected, undefined);
+      assertMatch(span.name, new RegExp(expected.op));
+      assertMatch(span.name, new RegExp(expected.key));
+      assert.strictEqual(span.kind, SpanKind.CLIENT);
+      assert.strictEqual(span.attributes['db.statement'], expected.statement);
+      for (const attr in DEFAULT_ATTRIBUTES) {
+        assert.strictEqual(span.attributes[attr], DEFAULT_ATTRIBUTES[attr]);
+      }
+      assert.strictEqual(span.attributes['db.memcached.key'], expected.key);
+      assert.strictEqual(
+        typeof span.attributes['memcached.version'],
+        'string',
+        'memcached.version not specified'
+      );
+      assert.deepEqual(
+        span.status,
+        expected.status || { code: SpanStatusCode.UNSET }
+      );
+      assert.strictEqual(span.attributes['db.operation'], expected.op);
+      assert.strictEqual(
+        span.parentSpanId,
+        expected.parentSpan?.spanContext().spanId
+      );
+    } catch (e) {
+      e.message = `At span[${idx}]: ${e.message}`;
+      throw e;
+    }
+  });
+};
+
+const assertMatch = (str: string, regexp: RegExp, err?: any) => {
+  assert.ok(regexp.test(str), err ?? `Expected '${str} to match ${regexp}`);
+};
diff --git a/plugins/node/opentelemetry-instrumentation-memcached/tsconfig.json b/plugins/node/opentelemetry-instrumentation-memcached/tsconfig.json
new file mode 100644
index 00000000000..28be80d266c
--- /dev/null
+++ b/plugins/node/opentelemetry-instrumentation-memcached/tsconfig.json
@@ -0,0 +1,11 @@
+{
+  "extends": "../../../tsconfig.base",
+  "compilerOptions": {
+    "rootDir": ".",
+    "outDir": "build"
+  },
+  "include": [
+    "src/**/*.ts",
+    "test/**/*.ts"
+  ]
+}