diff --git a/src/tests/Common/Platform/platformdefines.h b/src/tests/Common/Platform/platformdefines.h
index 043aedee30e20..3be7429437f60 100644
--- a/src/tests/Common/Platform/platformdefines.h
+++ b/src/tests/Common/Platform/platformdefines.h
@@ -18,6 +18,13 @@
 #define _CRT_SECURE_NO_WARNINGS 1
 #endif
 
+#if defined(TARGET_X86) || defined(TARGET_AMD64)
+#define TARGET_XARCH
+#endif
+
+#if defined(TARGET_ARM) || defined(TARGET_ARM64)
+#define TARGET_ARMARCH
+#endif
 
 // Ensure that both UNICODE and _UNICODE are set.
 #ifndef _UNICODE
diff --git a/src/tests/Directory.Build.props b/src/tests/Directory.Build.props
index c0dcca32e0653..45d0c1ee26c87 100644
--- a/src/tests/Directory.Build.props
+++ b/src/tests/Directory.Build.props
@@ -139,6 +139,7 @@
     <TargetBits>32</TargetBits>
     <TargetBits Condition="'$(TargetArchitecture)'=='x64'">64</TargetBits>
     <TargetBits Condition="'$(TargetArchitecture)'=='arm64'">64</TargetBits>
+    <TargetBits Condition="'$(TargetArchitecture)'=='loongarch64'">64</TargetBits>
   </PropertyGroup>
 
   <PropertyGroup>
diff --git a/src/tests/Interop/PInvoke/Generics/CMakeLists.txt b/src/tests/Interop/PInvoke/Generics/CMakeLists.txt
index 67b1020d6ec96..62baff4017164 100644
--- a/src/tests/Interop/PInvoke/Generics/CMakeLists.txt
+++ b/src/tests/Interop/PInvoke/Generics/CMakeLists.txt
@@ -1,18 +1,5 @@
 project (GenericsNative)
 include ("${CLR_INTEROP_TEST_ROOT}/Interop.cmake")
-if(CLR_CMAKE_TARGET_ARCH_I386)
-  add_definitions(-DTARGET_X86)
-  add_definitions(-DTARGET_XARCH)
-elseif(CLR_CMAKE_TARGET_ARCH_AMD64)
-  add_definitions(-DTARGET_AMD64)
-  add_definitions(-DTARGET_XARCH)
-elseif(CLR_CMAKE_TARGET_ARCH_ARM)
-  add_definitions(-DTARGET_ARM)
-  add_definitions(-DTARGET_ARMARCH)
-elseif(CLR_CMAKE_TARGET_ARCH_ARM64)
-  add_definitions(-DTARGET_ARM64)
-  add_definitions(-DTARGET_ARMARCH)
-endif()
 if (CMAKE_CXX_COMPILER_ID STREQUAL "GNU")
   # The ABI for passing parameters with 32-byte alignment has changed in GCC 4.6
   add_compile_options(-Wno-psabi)
diff --git a/src/tests/Interop/PInvoke/Generics/GenericsNative.Vector128B.cpp b/src/tests/Interop/PInvoke/Generics/GenericsNative.Vector128B.cpp
index ff2bd457895f3..97175c18a9ab3 100644
--- a/src/tests/Interop/PInvoke/Generics/GenericsNative.Vector128B.cpp
+++ b/src/tests/Interop/PInvoke/Generics/GenericsNative.Vector128B.cpp
@@ -10,7 +10,7 @@
     #include <emmintrin.h>
 
     typedef __m128i Vector128B;
-#elif defined(TARGET_ARMARCH)
+#elif defined(TARGET_ARMARCH) || defined(TARGET_LOONGARCH64)
     #if defined(_MSC_VER)
         #if defined(TARGET_ARM64)
             #include <arm64_neon.h>
diff --git a/src/tests/Interop/PInvoke/Generics/GenericsNative.Vector128C.cpp b/src/tests/Interop/PInvoke/Generics/GenericsNative.Vector128C.cpp
index f272895cde757..146cfba6927ca 100644
--- a/src/tests/Interop/PInvoke/Generics/GenericsNative.Vector128C.cpp
+++ b/src/tests/Interop/PInvoke/Generics/GenericsNative.Vector128C.cpp
@@ -10,7 +10,7 @@
     #include <emmintrin.h>
 
     typedef __m128i Vector128C;
-#elif defined(TARGET_ARMARCH)
+#elif defined(TARGET_ARMARCH) || defined(TARGET_LOONGARCH64)
     #if defined(_MSC_VER)
         #if defined(TARGET_ARM64)
             #include <arm64_neon.h>
diff --git a/src/tests/Interop/PInvoke/Generics/GenericsNative.Vector128D.cpp b/src/tests/Interop/PInvoke/Generics/GenericsNative.Vector128D.cpp
index c854833191a23..f3c7aa4b5f28a 100644
--- a/src/tests/Interop/PInvoke/Generics/GenericsNative.Vector128D.cpp
+++ b/src/tests/Interop/PInvoke/Generics/GenericsNative.Vector128D.cpp
@@ -10,7 +10,7 @@
     #include <emmintrin.h>
 
     typedef __m128d Vector128D;
-#elif defined(TARGET_ARMARCH)
+#elif defined(TARGET_ARMARCH) || defined(TARGET_LOONGARCH64)
     #if defined(_MSC_VER)
         #if defined(TARGET_ARM64)
             #include <arm64_neon.h>
diff --git a/src/tests/Interop/PInvoke/Generics/GenericsNative.Vector128F.cpp b/src/tests/Interop/PInvoke/Generics/GenericsNative.Vector128F.cpp
index ddd77d0a187bf..f5c4d237b77cc 100644
--- a/src/tests/Interop/PInvoke/Generics/GenericsNative.Vector128F.cpp
+++ b/src/tests/Interop/PInvoke/Generics/GenericsNative.Vector128F.cpp
@@ -10,7 +10,7 @@
     #include <xmmintrin.h>
 
     typedef __m128 Vector128F;
-#elif defined(TARGET_ARMARCH)
+#elif defined(TARGET_ARMARCH) || defined(TARGET_LOONGARCH64)
     #if defined(_MSC_VER)
         #if defined(TARGET_ARM64)
             #include <arm64_neon.h>
diff --git a/src/tests/Interop/PInvoke/Generics/GenericsNative.Vector128L.cpp b/src/tests/Interop/PInvoke/Generics/GenericsNative.Vector128L.cpp
index a46650c186344..211249ccf8696 100644
--- a/src/tests/Interop/PInvoke/Generics/GenericsNative.Vector128L.cpp
+++ b/src/tests/Interop/PInvoke/Generics/GenericsNative.Vector128L.cpp
@@ -10,7 +10,7 @@
     #include <emmintrin.h>
 
     typedef __m128i Vector128L;
-#elif defined(TARGET_ARMARCH)
+#elif defined(TARGET_ARMARCH) || defined(TARGET_LOONGARCH64)
     #if defined(_MSC_VER)
         #if defined(TARGET_ARM64)
             #include <arm64_neon.h>
diff --git a/src/tests/Interop/PInvoke/Generics/GenericsNative.Vector128U.cpp b/src/tests/Interop/PInvoke/Generics/GenericsNative.Vector128U.cpp
index d74a1eef96f46..08c6cfc4def3b 100644
--- a/src/tests/Interop/PInvoke/Generics/GenericsNative.Vector128U.cpp
+++ b/src/tests/Interop/PInvoke/Generics/GenericsNative.Vector128U.cpp
@@ -10,7 +10,7 @@
     #include <emmintrin.h>
 
     typedef __m128i Vector128U;
-#elif defined(TARGET_ARMARCH)
+#elif defined(TARGET_ARMARCH) || defined(TARGET_LOONGARCH64)
     #if defined(_MSC_VER)
         #if defined(TARGET_ARM64)
             #include <arm64_neon.h>
diff --git a/src/tests/Interop/PInvoke/Generics/GenericsNative.Vector256B.cpp b/src/tests/Interop/PInvoke/Generics/GenericsNative.Vector256B.cpp
index 985c4116bfe28..f51ea87767ea1 100644
--- a/src/tests/Interop/PInvoke/Generics/GenericsNative.Vector256B.cpp
+++ b/src/tests/Interop/PInvoke/Generics/GenericsNative.Vector256B.cpp
@@ -8,7 +8,7 @@
 
 #if defined(TARGET_XARCH)
     #include <immintrin.h>
-#elif defined(TARGET_ARMARCH)
+#elif defined(TARGET_ARMARCH) || defined(TARGET_LOONGARCH64)
     // Intentionally empty
 #else
     #error Unsupported target architecture
diff --git a/src/tests/Interop/PInvoke/Generics/GenericsNative.Vector256C.cpp b/src/tests/Interop/PInvoke/Generics/GenericsNative.Vector256C.cpp
index e567af1e01325..a489455f42994 100644
--- a/src/tests/Interop/PInvoke/Generics/GenericsNative.Vector256C.cpp
+++ b/src/tests/Interop/PInvoke/Generics/GenericsNative.Vector256C.cpp
@@ -8,7 +8,7 @@
 
 #if defined(TARGET_XARCH)
     #include <immintrin.h>
-#elif defined(TARGET_ARMARCH)
+#elif defined(TARGET_ARMARCH) || defined(TARGET_LOONGARCH64)
     // Intentionally empty
 #else
     #error Unsupported target architecture
diff --git a/src/tests/Interop/PInvoke/Generics/GenericsNative.Vector256D.cpp b/src/tests/Interop/PInvoke/Generics/GenericsNative.Vector256D.cpp
index abde579656f00..46d0c7d2ac72a 100644
--- a/src/tests/Interop/PInvoke/Generics/GenericsNative.Vector256D.cpp
+++ b/src/tests/Interop/PInvoke/Generics/GenericsNative.Vector256D.cpp
@@ -8,7 +8,7 @@
 
 #if defined(TARGET_XARCH)
     #include <immintrin.h>
-#elif defined(TARGET_ARMARCH)
+#elif defined(TARGET_ARMARCH) || defined(TARGET_LOONGARCH64)
     // Intentionally empty
 #else
     #error Unsupported target architecture
diff --git a/src/tests/Interop/PInvoke/Generics/GenericsNative.Vector256F.cpp b/src/tests/Interop/PInvoke/Generics/GenericsNative.Vector256F.cpp
index f941896286510..3d62cd6ed1a87 100644
--- a/src/tests/Interop/PInvoke/Generics/GenericsNative.Vector256F.cpp
+++ b/src/tests/Interop/PInvoke/Generics/GenericsNative.Vector256F.cpp
@@ -8,7 +8,7 @@
 
 #if defined(TARGET_XARCH)
     #include <immintrin.h>
-#elif defined(TARGET_ARMARCH)
+#elif defined(TARGET_ARMARCH) || defined(TARGET_LOONGARCH64)
     // Intentionally empty
 #else
     #error Unsupported target architecture
diff --git a/src/tests/Interop/PInvoke/Generics/GenericsNative.Vector256L.cpp b/src/tests/Interop/PInvoke/Generics/GenericsNative.Vector256L.cpp
index 744c8ed6527bd..797385db5fa34 100644
--- a/src/tests/Interop/PInvoke/Generics/GenericsNative.Vector256L.cpp
+++ b/src/tests/Interop/PInvoke/Generics/GenericsNative.Vector256L.cpp
@@ -8,7 +8,7 @@
 
 #if defined(TARGET_XARCH)
     #include <immintrin.h>
-#elif defined(TARGET_ARMARCH)
+#elif defined(TARGET_ARMARCH) || defined(TARGET_LOONGARCH64)
     // Intentionally empty
 #else
     #error Unsupported target architecture
diff --git a/src/tests/Interop/PInvoke/Generics/GenericsNative.Vector256U.cpp b/src/tests/Interop/PInvoke/Generics/GenericsNative.Vector256U.cpp
index 2e3e5421a34e4..d433035d5487a 100644
--- a/src/tests/Interop/PInvoke/Generics/GenericsNative.Vector256U.cpp
+++ b/src/tests/Interop/PInvoke/Generics/GenericsNative.Vector256U.cpp
@@ -8,7 +8,7 @@
 
 #if defined(TARGET_XARCH)
     #include <immintrin.h>
-#elif defined(TARGET_ARMARCH)
+#elif defined(TARGET_ARMARCH) || defined(TARGET_LOONGARCH64)
     // Intentionally empty
 #else
     #error Unsupported target architecture
diff --git a/src/tests/Interop/PInvoke/Generics/GenericsNative.Vector64B.cpp b/src/tests/Interop/PInvoke/Generics/GenericsNative.Vector64B.cpp
index b3a70aba36b03..8563ba4e0224d 100644
--- a/src/tests/Interop/PInvoke/Generics/GenericsNative.Vector64B.cpp
+++ b/src/tests/Interop/PInvoke/Generics/GenericsNative.Vector64B.cpp
@@ -10,7 +10,7 @@
     #include <mmintrin.h>
 
     typedef __m64 Vector64B;
-#elif defined(TARGET_ARMARCH)
+#elif defined(TARGET_ARMARCH) || defined(TARGET_LOONGARCH64)
     #if defined(_MSC_VER)
         #if defined(TARGET_ARM64)
             #include <arm64_neon.h>
diff --git a/src/tests/Interop/PInvoke/Generics/GenericsNative.Vector64C.cpp b/src/tests/Interop/PInvoke/Generics/GenericsNative.Vector64C.cpp
index 54d046d3118c3..8f597d3af4682 100644
--- a/src/tests/Interop/PInvoke/Generics/GenericsNative.Vector64C.cpp
+++ b/src/tests/Interop/PInvoke/Generics/GenericsNative.Vector64C.cpp
@@ -10,7 +10,7 @@
     #include <mmintrin.h>
 
     typedef __m64 Vector64C;
-#elif defined(TARGET_ARMARCH)
+#elif defined(TARGET_ARMARCH) || defined(TARGET_LOONGARCH64)
     #if defined(_MSC_VER)
         #if defined(TARGET_ARM64)
             #include <arm64_neon.h>
diff --git a/src/tests/Interop/PInvoke/Generics/GenericsNative.Vector64D.cpp b/src/tests/Interop/PInvoke/Generics/GenericsNative.Vector64D.cpp
index 3309f59a78c28..98b0519850275 100644
--- a/src/tests/Interop/PInvoke/Generics/GenericsNative.Vector64D.cpp
+++ b/src/tests/Interop/PInvoke/Generics/GenericsNative.Vector64D.cpp
@@ -10,7 +10,7 @@
     #include <mmintrin.h>
 
     typedef __m64 Vector64D;
-#elif defined(TARGET_ARMARCH)
+#elif defined(TARGET_ARMARCH) || defined(TARGET_LOONGARCH64)
     #if defined(_MSC_VER)
         #if defined(TARGET_ARM64)
             #include <arm64_neon.h>
diff --git a/src/tests/Interop/PInvoke/Generics/GenericsNative.Vector64F.cpp b/src/tests/Interop/PInvoke/Generics/GenericsNative.Vector64F.cpp
index 2714f4e530e46..f4b5aad32781f 100644
--- a/src/tests/Interop/PInvoke/Generics/GenericsNative.Vector64F.cpp
+++ b/src/tests/Interop/PInvoke/Generics/GenericsNative.Vector64F.cpp
@@ -10,7 +10,7 @@
     #include <mmintrin.h>
 
     typedef __m64 Vector64F;
-#elif defined(TARGET_ARMARCH)
+#elif defined(TARGET_ARMARCH) || defined(TARGET_LOONGARCH64)
     #if defined(_MSC_VER)
         #if defined(TARGET_ARM64)
             #include <arm64_neon.h>
diff --git a/src/tests/Interop/PInvoke/Generics/GenericsNative.Vector64L.cpp b/src/tests/Interop/PInvoke/Generics/GenericsNative.Vector64L.cpp
index 04effb11e2ef8..8401ce572245f 100644
--- a/src/tests/Interop/PInvoke/Generics/GenericsNative.Vector64L.cpp
+++ b/src/tests/Interop/PInvoke/Generics/GenericsNative.Vector64L.cpp
@@ -10,7 +10,7 @@
     #include <mmintrin.h>
 
     typedef __m64 Vector64L;
-#elif defined(TARGET_ARMARCH)
+#elif defined(TARGET_ARMARCH) || defined(TARGET_LOONGARCH64)
     #if defined(_MSC_VER)
         #if defined(TARGET_ARM64)
             #include <arm64_neon.h>
diff --git a/src/tests/Interop/PInvoke/Generics/GenericsNative.Vector64U.cpp b/src/tests/Interop/PInvoke/Generics/GenericsNative.Vector64U.cpp
index cd1bad61e2c23..8a0f79faf2b73 100644
--- a/src/tests/Interop/PInvoke/Generics/GenericsNative.Vector64U.cpp
+++ b/src/tests/Interop/PInvoke/Generics/GenericsNative.Vector64U.cpp
@@ -10,7 +10,7 @@
     #include <mmintrin.h>
 
     typedef __m64 Vector64U;
-#elif defined(TARGET_ARMARCH)
+#elif defined(TARGET_ARMARCH) || defined(TARGET_LOONGARCH64)
     #if defined(_MSC_VER)
         #if defined(TARGET_ARM64)
             #include <arm64_neon.h>
diff --git a/src/tests/Interop/PInvoke/Int128/CMakeLists.txt b/src/tests/Interop/PInvoke/Int128/CMakeLists.txt
index 9474de8c3dcd6..17690db349b4b 100644
--- a/src/tests/Interop/PInvoke/Int128/CMakeLists.txt
+++ b/src/tests/Interop/PInvoke/Int128/CMakeLists.txt
@@ -1,18 +1,5 @@
 project (Int128Native)
 include ("${CLR_INTEROP_TEST_ROOT}/Interop.cmake")
-if(CLR_CMAKE_TARGET_ARCH_I386)
-  add_definitions(-DTARGET_X86)
-  add_definitions(-DTARGET_XARCH)
-elseif(CLR_CMAKE_TARGET_ARCH_AMD64)
-  add_definitions(-DTARGET_AMD64)
-  add_definitions(-DTARGET_XARCH)
-elseif(CLR_CMAKE_TARGET_ARCH_ARM)
-  add_definitions(-DTARGET_ARM)
-  add_definitions(-DTARGET_ARMARCH)
-elseif(CLR_CMAKE_TARGET_ARCH_ARM64)
-  add_definitions(-DTARGET_ARM64)
-  add_definitions(-DTARGET_ARMARCH)
-endif()
 set(SOURCES
   Int128Native.cpp
   UInt128Native.cpp
diff --git a/src/tests/Interop/StructMarshalling/PInvoke/MarshalStructAsParamDLL.h b/src/tests/Interop/StructMarshalling/PInvoke/MarshalStructAsParamDLL.h
index 4a74572717890..3f77f7ffac1e3 100644
--- a/src/tests/Interop/StructMarshalling/PInvoke/MarshalStructAsParamDLL.h
+++ b/src/tests/Interop/StructMarshalling/PInvoke/MarshalStructAsParamDLL.h
@@ -197,7 +197,7 @@ struct OUTER3
 static_assert_no_msg(sizeof(OUTER3) == 28);
 #endif
 #else // WINDOWS
-#if defined(__x86_64__) || defined(__aarch64__)
+#if defined(__x86_64__) || defined(__aarch64__) || defined(__loongarch64)
 union OUTER3
 {
     struct InnerSequential arr[2];